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The local groups retain traditional wisdom that has been passed down through the years. There are 538 mandals and 130 municipalities in Telangana State.In Telangana State Biodiversity Board (TSBB), has established Biodiversity Management Committees (BMC) in all villages. In People Biodiversity Registers (PBR), locals and technical support organizations document native biodiversity and bio-resources. The village resources, including its socioeconomic, historical, and cultural aspects as well as its natural habitats, are documented by the Biodiversity Management Committee. These habitats include lakes, springs, rare ecological habitat versatility, agro-physiological ecological systems, and ancient distinctive hydrogeological structures made possible by regional methods for managing surface water. The research study of Variguntham village in Telangana, where locals have recorded the bioresources is covered in the article. As a result of the PBR documentation procedure, there are new species identified in communities and agricultural biodiversity. Through PBR four categories have been documented, including 31 type of crops species, 13 type of weeds, 4 types of fruit plants and 13 types of a crop pest. TSBB endeavours to promote historically farmed rice types by giving them a brand identity and recreating ancient customs, etc.

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The current study intends to find out the efficacy of Orlistat in the management of hyperlipidemia, Systolic Blood Pressure (SBP) and Body Mass Index (BMI).This retrospective study has evaluated the lipid profiles of the patients, who have been using metformin therapy for Type 2 diabetes. The study has obtained data regarding the parameters like triglyceride, Total cholesterol (TC), LDL cholesterol, HDL cholesterol and LDL/HDL ratio, systolic blood pressure and Body Mass Index (BMI). Random distribution of patients was done into placebo and Orlistat groups. The placebo group received only metformin, and patients in the Orlistat group received Orlistat along with metformin. After 24 weeks, the follow-up study was done, and statistical analysis was conducted.The study found that the Orlistat group has significant improvement (p0.05) more improvement in LDL cholesterol, HDL cholesterol, Total cholesterol, LDL/HDL Ratio and Triglycerides, while BMI and systolic blood pressure did not show a significant difference between placebo and Orlistat group.This study has concluded that Orlistat can be used for significant improvement in lipid profile. The study also found that Orlistat may not have a significant effect on reducing BMI and blood pressure without adequate lifestyle modification.

Aims: To present the awareness and attitude towards measles vaccination among the population of Hai’l region in Saudi Arabia. Methodology: A cross-sectional electronic survey was conducted from October 2019 to January 2020 and received 469 samples from the residents of the Hai’l province. The convenient sampling technique was used to collect data through questionnaire sent by emails to participants. Results: The prevalence of measles in Hai’l region was 7.8% and 96.1% of the population has been vaccinated. About 46% of the population did not know what caused measles, whereas, 37% knew it was a viral disease. About 85.5% believed vaccination is best method to prevent measles and 45.5% of population think that vaccine is the treatment for measles. And, 64.6% think the agencies do good work in promoting measles awareness. Conclusion: The prevalence of measles in Hai’l province of Saudi Arabia is low with almost all vaccinated. The knowledge and awareness about measles is adequate. The study suggests that the surveillance, monitoring as well as educational and awareness programs needs more attention.

Millimeter-wave massive multiple-input multiple-output (MIMO) employs a lens antenna array for minimizing the radio frequency (RF) chains count, yet it remains as a challenge since the RF chain count is lesser when compared to the antennas. The beamspace channel estimation is defined as a sparse signal recovery problem through the exploitation of sparsity of beamspace channels. In the case of multi-user millimeter wave (mmWave) MIMO-OFDM systems, the critical task to lessen the cost as well as the complexity is the hybrid precoding attaining an adequate sum-rate. The conventional approaches related to the hybrid precoding works on the basis of the greedy or optimization techniques. These techniques suffer from higher complexity or contain sub-optimum performance. The main intent of this paper is to plan for the adaptive deep learning strategy for sparse channel estimation and hybrid precoding in millimeter-wave massive MIMO-OFDM communication system. The proposed methodology covers two main phases (a) uplink channel estimation, and (b) hybrid precoding for downlink data transmission. In the first phase, an adaptive deep neural network (ADNN) is used for performing the uplink channel estimation. Here, the benchmark dataset is used for training the information to be predicted at base station regarding the channel. Here, the ADNN-based channel estimation covers both channel amplitude estimation and channel reconstruction. Once the channel reconstruction is done, hybrid pre-coding performs the downlink data transmission that involves both digital and analog pre-coders. Here, the adaptive long short term memory (ALSTM) is used for performing the hybrid pre-coding, in which the estimated channel vectors is used for training. For both sparse channel estimation and hybrid-precoding, the trial-based red deer algorithm (T-RDA) is used for improvising the ADNN and ALSTM, in which it optimizes or tunes the training hidden neurons. The main objective of tuning the hidden neurons in both phases of T-RDA is to maximize the accuracy. When SNR equals 15 dB, the NMSE of the T-RDA-ADNN is 40%, 25%, 37.5%, and 34.78% improved than RDA-ADNN, SFO-ADNN, GWO-ADNN, and PSO-ADNN for channel estimation. Similarly, at SNR 20 dB, the spectral efficiency of T-RDA-ADNN is 37.5%, 43.48%, 22.22%, and 94.12% advanced than RDA-ADNN, SFO-ADNN, GWO-ADNN, and PSO-ADNN for hybrid precoding. Thus, the simulation outcomes show that the developed sparse channel estimation and hybrid pre-coding in mmWave massive MIMO-OFDM communication system has attained lesser error and high spectral efficiency when differentiated over the existing approaches.

Background: Triphala, which is a combination of fruits of Terminalia chebula, Terminalia bellerica and Embilica officinalis generally recommended as herbal drug formulation in the Indian traditional medicine system. Study Design: To study the in-silico inhibitory potential of Triphala constituents against cytochrome P450 2E1 (CYP2E1) for the prevention of Thioacetamide-induced Hepatotoxicity Place and Duration of Study: The work has been performed at MUP's College of Pharmacy (B Pharm), Degaon, Risod, Washim, Maharashtra, India in between February 2021 to May 2021. Methodology: We have studied the inhibitory potential of Triphala on CYP2E1 by applying molecular docking tools. The major chemical constituents of Triphala i.e. gallic acid, chebulic acid, ellagic acid, epicatechin, syringic acid, and ascorbic acid were docked on CYP2E1. Results: Docking results revealed the very good inhibitory potential of Triphala in terms of binding affinity towards CYP2E1. All the chemical constituents have formed at least 2 and at most 6 hydrogen bonds with the crystal structure of CYP2E1. The binding energies (kcal/mol) of gallic acid, chebulic acid, ellagic acid, epicatechin, syringic acid, and ascorbic acid are -6.1, -7.1, -9.1, -8.3, -6.3, and -5.7, respectively. Ellagic acid has formed strong hydrogen bonds with Thr-303 and Thr-304 with bond length of 1.98 A0 and 2.26 A0 which confirms the excellent inhibition of CYP2E1. Conclusion: These findings can be used to control the CYP2E1-facilitated biotransformation and drug interactions in the development of new chemical entities. In future, these phytoconstituents can be used as lead molecules to overcome the cancer associated with oxidative stress resulting from the hyperactivity of CYP2E1.

COVID-19 can cause disturbances in insulin production and worsen the clinical condition of patients with comorbid diabetes mellitus. In patients with diabetes mellitus, one of the complications is heart disease. Therefore, a study was conducted to determine the relationship between hs-Troponin I levels, which is a biomarker of heart disease, with the severity of COVID-19 patients as measured by the Brixia score in COVID-19 patients with comorbid diabetes mellitus in the ICU (Intensive Care Unit) of Dr. Moewardi Hospital, Surakarta. The study was conducted with a cross-sectional approach, the sample was COVID-19 patients with comorbid diabetes mellitus in the ICU, chosen by purposive sampling method. The dependent variable of this study was the Brixia score, and hs-Troponin I would be the independent variable. Data were analyzed by contingency coefficient test with p0,05) and r=0,245 showed that there is no significant relationship between hs-Troponin I and Brixia score. Hs-Troponin I level is negatively correlated to Brixia score in COVID-19 patients with diabetes mellitus.

The aim of the study is to design N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine derivatives and evaluate its anti-obesity activity.A few pyrazole-fused benzimidazole derivatives were designed as potential Pancreatic Lipase (PL) inhibitors. The designed N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine derivatives have been screened using the Lipinski rule of five, ADMET analysis, acute toxicity prediction, and molecular docking. Later on, the derivatives which possess the most drug-likeness properties and displayed the most potent inhibition of the enzyme in molecular docking were synthesized. Then, in vitro enzyme assay was performed.Orlistat used as the standard exhibited 91±1.68% inhibition of the enzyme, displayed binding affinity (BA) of only -4.5 kcal/mol with Pancreatic Lipase (PL), and made only one salt bridge attractive charge and carbon-hydrogen bond with ASP79 and TRP252, respectively. Compound 9 displayed the most potent activity (93±1.12% inhibition of P.L. and -9.5 kcal/mol BA). It has formed five conventional H- bonds with GLU253, ILE78, ASP79, PHE258, and one Pi-donor H- bond with ILE78. From the present investigation, we hereby reported (E)-N2-((naphthalene-1-yl)methylene)-N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine as most potent PL inhibitor for the treatment of obesity, which can be further optimized by undergoing more studies using in vivo and in vitro models.(E)-N2-((naphthalene-1-yl)methylene)-N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine as most potent PL inhibitor for the treatment of obesity which can be further optimized better using more in vivo and in vitro models. PL plays a critical role in digesting dietary fat. Therefore, PL inhibitors are verified as a potential therapy for treating obesity.

The aim of the study was to analyze if there was a link between chronic diseases, like cardiovascular disease (CVD) and osteoarthritis (OA), and obesity in the population of Saudi Arabia's Hail region.The study was conducted over 12 months using an observational cross-sectional survey on 172 patients from five clinics in Hail, Saudi Arabia. A total of 172 individuals with obesity (BMI ≥ 30) finally participated in this research. The study evaluated sociodemographic variables via an electronic questionnaire with voluntary participation.The study found a 76% prevalence of joint pain and 77.9% prevalence of cardiovascular abnormalities. Patients with CVD were older (58±23 vs. 56±12 years) than those with OA. CVD cases were found in 42 (31.3%) males and 92 (68.7%) females, whereas OA cases were recognized in 24 (18.5%) males and 106 (81.5%) females. The occurrence of various CVDs among our participants was 43 (32%) for high cholesterol, 64 (48%) for hypertension, and 27 for both high cholesterol and hypertension (20%). Definite osteophytes were found in 28 of 24 male knees (14 right and 14 left knees) and 175 of 106 female knees (88 right knees and 87 left knees).The prevalence of obesity in the Hail region has continued to be a risk factor for CVD and OA in 2019 and 2020. The Saudi population has shown a higher prevalence of radiographic evidence of OA of the knee and associated symptoms than western civilizations, and preventive interventions are desperately needed in order to minimize overweight and obesity.

study was taken to document the bio-resource of Ginnedhari village in Telangana, through Peoples Biodiversity Register (PBR’S) for the year 2018-2019. The documentation was done by following the NBA (National Biodiversity Authority) performa, the data was collected from the village through interaction data collection from officials, and discussion with village people. The indigenous knowledge of various aspects of local biodiversity indicates that under the agro biodiversity 31 types of crops and 13 types of pest of crops were identified followed by 13 species of weeds, and 4 types of fruit plants. Among the wild plant biodiversity 36medicinal plants, 4 fumigator plants, 12 timber plants, and 11 ornamental plants were identified. The wild relative plant biodiversity under the plant identified are shrubs 9, herbs 4, grasses 4, and climber 2, 6 types of wild animals, 12 types of wild birds, and 8 types of reptiles are present, the data about domesticated biodiversity indicates 6 types of mammals, 2 types of birds and 2 types of reptiles. The documented bio resources are a ready reckoner to the village people BMC (Biodiversity Management Committee), TSBB (Telangana State Biodiversity Board), and NBA for resource conservation and access benefit sharing, patenting, and economic value to the specific village

Air pollution is considered to be one of the major issues throughout the globe majorly in many developing cities like Hyderabad. Addressing this kind of pollution is more complicated than other ecological challenges. In present study is aimed at assessing the air pollution tolerant plant species from two different locations in Hyderabad city. The study was carried out by using commonly available eighteen selected plant species from polluted and control areas. Their Air Pollution Tolerance Index (APTI) was determined by using biochemical parameters viz. pH, Ascorbic acid, Total Chlorophyll, and Relative Water Content (RWC) to calculate APTI by using the standard method. The present study reveals that the control site has more APTI than the polluted site. The lowest APTI was found in Hibiscus rosasinencis (5.24) whereas the highest APTI was found in Syzygium cumini (11.83). The minimum APTI reduction percentage compared to the control site was observed in Bougainvillea glabra (3.82%) and maximum in Pdilanthus tithimiloides (28.92%). Percentage of Reduction in APTI at polluted site showed that Pdilanthus tithimiloides (28.92%) > Casia fistula (28.75) > Pongamia pinneta (24.36%) > Senna auriculata (23.55%)> Lantana camara (23.15%) > Hibiscus rosasinencis (22.02%) > Tinospora cardifolia (17.00%) > Psidium guava (15.79%)> Mangifera indica 15.65%) > Albizia lebbeck (14.77%)> Catharanthus roseus (13.55%)>Azadirecta indica (13.00%)> Annona reticulata (12.47%) > Baliospermum solanifolium (6.71%)> Syzygium cumini (5.83%) > Couroupita guianensis (5.52%) > Ficus religiosa (5.65%) >Bougainvillea glabra (3.82%) were more sensitive tree species. The tolerant tree species can be served as a sink, and sensitive tree species can act as an indicator for air pollution moderation. Thus, this study provides valuable insight for selecting tolerant plant species for future planning and greenbelt development in and around the industrial regions of Hyderabad city. For reducing air pollution and improving the health of humans and environment.

The aim of the study was to analytically compare the therapeutic effect of the addition of diet modification and regular exercise to oral agents.This cross-sectional study surveyed 1248 participants via online and offline modes by employing a questionnaire about an individual's management of diabetes. Group 1 patients follow Single Approach Management for Type 2 Diabetes Mellitus (T2DM), while Group 2 and Group 3 patients follow Multi-Approach Management for T2DM. Based on the answers, the participants were classified into three groups. The diagnostic criteria of Diabetes Mellitus Type-2 in this study were done by determining morning Fasting Blood Sugar (FBS) and glycated Hemoglobin (HbA1c).The current study found 656 single oral agent users and 592 combination regimens users among all the study participants. The study also found that, among all participants, 511 patients were on mild to moderate diet modification while 325 patients were on moderate to severe diet modification. The study also noted that 232 males and 215 females took Complementary and Alternative Medicines (CAM). Of 447 patients, 12 showed menstrual abnormalities (2.6%), and 18 had mild diarrhoea (4%). The study also found that there is a vital significance of lowering FBS and HbA1c with the management strategies (p=0.000). The study showed a strong association between group 3 and improved FBS and HbA1c (p=0.000).This study reveals that diet modification and regular exercise improve FBS and HbA1c levels significantly. Hence, diet modification and exercise can be added as adjuvants and should be incorporated into the management guidelines of T2DM.