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156. Role of Inflammation in the Pathogenesis of Diverticular Disease

Author

Tursi, Antonio and Elisei, Walter

Subjects
Article Subject
Abstract

Diverticulosis of the colon is the most common condition in Western societies and it is the most common anatomic alteration of the human colon. Recurrent abdominal pain is experienced by about 20% of patients with diverticulosis, but the pathophysiologic mechanisms of its occurrence are not completely understood. In the last years, several fine papers have showed clearly the role of low-grade inflammation both in the occurrence of symptoms in people having diverticulosis, both in symptom persistence following acute diverticulitis, even if the evidence available is not so strong. We do not know yet what the trigger of this low-grade inflammation occurrence is. However, some preliminary evidence found colonic dysbiosis linked to low-grade inflammation and therefore to symptom occurrence in those patients. The aim of this paper is to summarize current evidences about the role of inflammation in symptom occurrence in symptomatic uncomplicated diverticular disease and in symptom persistence after an episode of acute diverticulitis.

Published
2019
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160. Real-Life Effectiveness and Safety of Golimumab and Its Predictors of Response in Patients with Ulcerative Colitis

Author

Bossa, Fabrizio, primary, Biscaglia, Giuseppe, additional, Valvano, Maria Rosa, additional, Costantino, Giuseppe, additional, Lauria, Angelo, additional, Clemente, Rocco, additional, Ferracane, Concetta, additional, Shahini, Endrit, additional, Mendolaro, Marco, additional, Grossi, Laurino, additional, Mazzuoli, Silvia, additional, Rispo, Antonio, additional, Pranzo, Giuseppe, additional, Sebkova, Ladislava, additional, Tursi, Antonio, additional, Miranda, Agnese, additional, Patturelli, Marta, additional, Spagnuolo, Rocco, additional, Ricciardelli, Cristina, additional, Sgarro, Caterina, additional, Paese, Pietro, additional, Inserra, Gaetano, additional, Azzarone, Alessandro, additional, Nardone, Olga, additional, Fries, Walter, additional, Buccianti, Nello, additional, Privitera, Antonino Carlo, additional, Principi, Maria Beatrice, additional, Cappello, Maria, additional, Guglielmi, Francesco William, additional, Romano, Marco, additional, Riegler, Gabriele, additional, Fanigliulo, Libera, additional, Melina, Raffaele, additional, and Andriulli, Angelo, additional

Published
2019
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165. Sa1204 – A Comparison of Different Treatments for Symptomatic Reflux Esophagitis: A Real-Life Study

Author

Mario, Francesco Di, primary, Crafa, Pellegrino, additional, Miraglia, Chiara, additional, Franzoni, Lorella, additional, Barchi, Alberto, additional, Tursi, Antonio, additional, Brandimarte, Giovanni, additional, Nouvenne, Antonio, additional, Elisei, Walter, additional, Picchio, Marcello, additional, Franceschi, Marilisa, additional, Savarino, Edoardo V., additional, and de Bortoli, Nicola, additional

Published
2019
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166. Sa1729 – Risk Factors for Colonic Diverticulosis: A Study in Primary Care Setting

Author

Violi, Alessandra, primary, Cambie', Ginevra, additional, Franceschi, Marilisa, additional, Baldassarre, Gianluca, additional, Rodriguez-Castro, Kryssia I., additional, Barchi, Alberto, additional, Moccia, Florenzo, additional, Franzoni, Lorella, additional, Miraglia, Chiara, additional, Crafa, Pellegrino, additional, Nouvenne, Antonio, additional, Brandimarte, Giovanni, additional, Tursi, Antonio, additional, and Mario, Francesco Di, additional

Published
2019
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167. Sa1728 – The Prognostic Value of a New Endoscopic Classification for Diverticular Disease: Dica (Diverticular Inflammation and Complication Assessment)

Author

Cambie', Ginevra, primary, Violi, Alessandra, additional, Tursi, Antonio, additional, Brandimarte, Giovanni, additional, Franceschi, Marilisa, additional, Franzoni, Lorella, additional, Rodriguez-Castro, Kryssia I., additional, Miraglia, Chiara, additional, Scida, Serena, additional, Barchi, Alberto, additional, Baldassarre, Gianluca, additional, Nouvenne, Antonio, additional, Crafa, Pellegrino, additional, and Mario, Francesco Di, additional

Published
2019
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174. Comparison of performances of infliximab biosimilars CT-P13 versus SB2 in the treatment of inflammatory bowel diseases: a real-life multicenter, observational study in Italy

Author

Tursi, Antonio, Mocci, Giammarco, Allegretta, Leonardo, Aragona, Giovanni, Bianco, Maria Antonia, Colucci, Raffaele, Cuomo, Antonio, Della Valle, Nicola, Ferronato, Antonio, Forti, Giacomo, Gaiani, Federica, Graziani, Maria Giovanna, Lorenzetti, Roberto, Luzza, Francesco, Paese, Pietro, Penna, Antonio, Pica, Roberta, Pranzo, Giuseppe, Rodinò, Stefano, Scarcelli, Antonella, Zampaletta, Costantino, Brozzi, Lorenzo, Cicerone, Clelia, Cocco, Andrea, De’ Angelis, Gianluigi, Donnarumma, Laura, Fiorella, Serafina, Iannelli, Chiara, Larussa, Tiziana, Le Grazie, Marco, Luppino, Ileana, Meucci, Costantino, FaggianI, Roberto, Pagnini, Cristiano, Perazzo, Patrizia, Rodriguez-Castro, Kryssia Isabel, Sacco, Rodolfo, Sebkova, Ladislava, Serio, Mariaelena, De Monti, Alberta, Picchio, Marcello, Napolitano, Daniele, Schiavoni, Elisa, Turchini, Laura, Scaldaferri, Franco, Pugliese, Daniela, Guidi, Luisa, Laterza, Lucrezia, Privitera, Giuseppe, Pizzoferrato, Marco, Lopetuso, Loris R., Armuzzi, Alessandro, Elisei, Walter, Maconi, Giovanni, and Papa, Alfredo

Abstract

ABSTRACTBackgroundTo compare the performances of Infliximab (IFX) biosimilar CT-P13 and SB2 in the treatment of Inflammatory Bowel Diseases (IBD) outpatients in Italy.Research Design and MethodsThree hundred and eighty IBD outpatients were retrospectively evaluated. The primary endpoint was to compare the two IFX biosimilars in terms of reaching and maintenance of remission at any timepoint.Results197 patients with Ulcerative Colitis (UC) and 183 patients with Crohn’s Disease (CD) treated with CT-P13 or SB2 and having a median (IQR) follow-up of 12 (6–36) months were compared: 230 (60.5%) were naïve to anti-TNFα, 20 (5.26%) were switched from IFX originator or from IFX CT-P13 to IFX SB2. Clinical remission was achieved in 133 (67.5%) UC patients and in 164 (89.6%) CD patients (p < 0.000), with no differences between CT-P13 and SB2 in the rate of remission in UC (p = 0.667) and CD (p = 0.286). Clinical response, steroid-free remission, rate of surgery, mucosal healing (MH) in UC, switching from IFX originator or from other biosimilar, and safety were similar. Higher MH rate was obtained in CD patients treated with CT-P13 (p = 0.004).ConclusionThis first comparative study found that both IFX biosimilars CT-P13 and SB2 are effective and safe in managing IBD outpatients.

Published
2022
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180. The natural history of symptomatic uncomplicated diverticular disease: a long-term follow-up study.

Author

Tursi, Antonio, Franceschi, Marilisa, Elisei, Walter, Picchio, Marcello, Di Mario, Francesco, and Brandimarte, Giovanni

Subjects
*DIVERTICULOSIS, *NATURAL history, *DIVERTICULITIS, *QUALITY of life, *ABDOMINAL pain, *SYMPTOMS
Abstract

Background Symptomatic uncomplicated diverticular disease (SUDD) affects about 20% of patients who have diverticulosis. However, the natural history of SUDD is not yet completely understood. Our aim was to assess the outcomes of a cohort of SUDD patients during a long-term follow up. Methods One hundred eighty-five patients suffering from SUDD were identified from a large electronic database. Symptoms assessed were abdominal pain, bloating, bowel movement/day, each of which was scored using a visual analogic scale (VAS); the symptom score was calculated by considering the value of the worst symptom present during assessment. Another VAS was used to assess patients' quality of life (QoL). Patients were treated at the physician's discretion (with rifaximin, mesalazine, probiotics, spasmolytics) only when symptoms occurred during the follow up. Follow-up visit was performed every year or whenever patients consider it necessary. Results During the follow up (156 months, interquartile range 9-171), 47 patients were lost to follow up. Among these, 9 died from causes not related to SUDD. Acute diverticulitis occurred in 14 patients (7.6% of the overall population): 6 patients (3.2% of the overall population) underwent surgery, and 2 patients (1.1% of the overall population) died because of peritonitis. Both the symptom score and the QoL score were substantially unmodified during the study period. Conclusions SUDD is an important disease able to affect patients significantly in the long term. Acute diverticulitis may sometimes occur in these patients, often leading to surgery with possible severe complications [ABSTRACT FROM AUTHOR]

Published
2021
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181. Il net-attivismo e la ridefinizione della democrazia

Author

Tursi, Antonio and Tursi, Antonio

Abstract

RiassuntoIl saggio analizza la relazione tra net-attivismo e democrazia. L’attivismo contemporaneo è significativamente contrassegnato dall’uso delle reti digitali di comunicazione. Di conseguenza riflette elementi caratteristici di queste reti, come i flussi di emozioni e la temporalità accelerata. La ridefinizione dell’attivismo richiede una nuova mappa interpretativa sviluppata tra due assi: globale/locale e riforma politica/riforma mediale. Il net-attivismo ha un impatto sulla definizione e le pratiche della democrazia, permettendo un allargamento dei repertori di azione disponibili agli individui e ai gruppi ma anche rischiando di allontanare la partecipazione dei cittadini dagli ambiti in cui le decisioni sono realmente prese.Parole chiave: media, democrazia, attivismo, partecipazione. AbstractThe paper analyses the relationship between net-activism and democracy. Contemporary activism is notably marked by the use of digital communication networks. It therefore reflects the characteristics of these networks, such as emotional flows and accelerated temporality. The redefinition of activism requires a new interpretive map developed between two axes: global/local and political reform/media reform. Net-Activism has an impact on the definition and practices of democracy, definitely marking an enlargement of the action repertoire available to individuals and to groups but also risks alienating the participation of citizens from the circles where decisions are made.Keywords: Media, Democracy, Activism, Participation.

Published
2018

182. Net-Activism and Redefining Democracy

Author

Tursi, Antonio

Abstract

Il capitolo di Antonio Tursi analizza la relazione tra net-attivismo e democrazia. L’attivismo contemporaneo si caratterizza per l’uso diffuso delle tecnologie digitali. Esso riflette così le loro caratteristiche come l’emozionalità e l’istantaneità. La ridefinzione dell’attivismo richiede una nuova mappa interpretativa che si sviluppa lungo due assi: globalelocale, politicamedia. Il net-attivismo ha un impatto notevole sulla definizione e sulle pratiche della democrazia, segnando un definitivo allargamento dei repertori d’azione disponibili per gli individui e I gruppi ma anche ponendo il rischio di un allontanamento della partecipazione dai luoghi decisionali., Net-Activism. How digital technologies have been changing individual and collective actions

Published
2017
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183. Sa1729 – Risk Factors for Colonic Diverticulosis: A Study in Primary Care Setting

Author

Baldassarre Gianluca, Barchi Alberto, Brandimarte Gianluca, Cryssia I. Rodriguez-Castro, Tursi Antonio, Violi Alessandra, Cambiè Ginevra, Lorella Franzoni, Franceschi Marilisa, Nouvenne Antonio, Moccia Florenzo, Chiara Miraglia, Pellegrino Crafa, and Francesco Di Mario

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, medicine, Primary care, Intensive care medicine, business, medicine.disease, Diverticulosis
Published
2019

186. International Consensus on Diverticulosis and Diverticular Disease. Statements from the 3rd International Symposium on Diverticular Disease.

Author

Tursi, Antonio, Brandimarte, Giovanni, Di Mario, Francesco, Lanas, Angel, Scarpignato, Carmelo, Bafutto, Mauro, Barbara, Giovanni, Bassotti, Gabrio, Binda, Gian Andrea, Biondi, Alberto, Biondo, Sebastiano, Cambie, Ginevra, Cassieri, Claudio, Crucitti, Antonio, Dumitrascu, Dan L., Elisei, Walter, Escalante, Ricardo, Herszenyi, László, Kruis, Wolfgang, and Kupcinskas, Juozas

Subjects
*DIVERTICULOSIS, *PATHOLOGY, *THERAPEUTICS, *DISEASE progression
Abstract

The statements produced by the Chairmen and Speakers of the 3rd International Symposium on Diverticular Disease, held in Madrid on April 11th-13th 2019, are reported. Topics such as current and evolving concepts on the pathogenesis, the course of the disease, the news in diagnosing, hot topics in medical and surgical treatments, and finally, critical issues on the disease were reviewed by the Chairmen who proposed 39 statements graded according to level of evidence and strength of recommendation. Each topic was explored focusing on the more relevant clinical questions. The vote was conducted on a 6-point scale and consensus was defined a priori as 67% agreement of the participants. The voting group consisted of 124 physicians from 18 countries, and agreement with all statements was provided. Comments were added explaining some controversial areas. [ABSTRACT FROM AUTHOR]

Published
2019
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189. Effectiveness and safety of adalimumab to treat outpatient ulcerative colitis

Author

Tursi, Antonio, primary, Elisei, Walter, additional, Faggiani, Roberto, additional, Allegretta, Leonardo, additional, Valle, Nicola Della, additional, Forti, Giacomo, additional, Franceschi, Marilisa, additional, Ferronato, Antonio, additional, Gallina, Sara, additional, Larussa, Tiziana, additional, Luzza, Francesco, additional, Lorenzetti, Roberto, additional, Mocci, Giammarco, additional, Penna, Antonio, additional, Rodino’, Stefano, additional, Sebkova, Ladislava, additional, de Medici, Antonio, additional, Pranzo, Giuseppe, additional, Ricciardelli, Cristina, additional, Grasso, Giuseppina, additional, Scorza, Stefano, additional, Zampaletta, Costantino, additional, and Picchio, Marcello, additional

Published
2018
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194. 50 - Reflux Esophagitis after Helicobacter Pylori Eradication: The Role of Gastric Acid Secretion

Author

Di Mario, Francesco, primary, Scida, Serena, additional, Franceschi, Marilisa, additional, Miraglia, Chiara, additional, Rodriguez, Kryssia, additional, Franzoni, Lorella, additional, Bertele, Anna, additional, Crafa, Pellegrino, additional, Cannizzaro, Renato, additional, Baldassarre, Gianluca, additional, Bo', Nadia Dal, additional, Tursi, Antonio, additional, Brandimarte, Giovanni, additional, Rugge, Massimo, additional, and Scarpignato, Carmelo, additional

Published
2018
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195. Tu1315 - Is the Interval Between the first and the Second H.P. Eradication Therapy Relevant for the Success of the Cure? A Comparison Between One Week, One Month and One Year

Author

Di Mario, Francesco, primary, Scida, Serena, additional, Tursi, Antonio, additional, Brandimarte, Giovanni, additional, Franceschi, Marilisa, additional, Crafa, Pellegrino, additional, Franzoni, Lorella, additional, Miraglia, Chiara, additional, Cavestro, Giulia M., additional, Cannizzaro, Renato, additional, Rugge, Massimo, additional, and Scarpignato, Carmelo, additional

Published
2018
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196. Tu1640 - The Clinical Outcome of Sudd: A 15-Years Prospective Study

Author

Di Mario, Francesco, primary, Miraglia, Chiara, additional, Scida, Serena, additional, Cambie', Ginevra, additional, Franceschi, Marilisa, additional, Violi, Alessandra, additional, Scarpignato, Carmelo, additional, Elisei, Walter, additional, Picchio, Marcello, additional, Brandimarte, Giovanni, additional, and Tursi, Antonio, additional

Published
2018
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197. Mo1194 - Natural History of Gastric Ulcer in a 25 Years Follow-Up: Role of Helicobacter Pylori Infection and Nonsteroidal Anti-Inflammatory Drugs

Author

Di Mario, Francesco, primary, Miraglia, Chiara, additional, Cavatorta, Ottavia, additional, Barchi, Alberto, additional, Capasso, Mario, additional, Franzoni, Lorella, additional, Crafa, Pellegrino, additional, Bo', Nadia Dal, additional, Cannizzaro, Renato, additional, Grande, Giuseppe, additional, Brandimarte, Giovanni, additional, Tursi, Antonio, additional, Scarpignato, Carmelo, additional, and Rugge, Massimo, additional

Published
2018
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198. Tu1237 - Epidemiology of Diverticular Disease of the Colon: A Preliminary Analysis from the International “Dica” Prospective Study

Author

Tursi, Antonio, primary, Brandimarte, Giovanni, additional, Di Mario, Francesco, additional, Elisei, Walter, additional, Picchio, Marcello, additional, Annunziata, Maria Laura, additional, Bafutto, Mauro, additional, Baldi, Fabio, additional, Danese, Silvio, additional, Dumitrascu, Dan Lucian, additional, Escalante, Ricardo, additional, Faggiani, Roberto, additional, Forti, Giacomo, additional, Franceschi, Marilisa, additional, Graziani, Maria G., additional, Lammert, Frank, additional, Latella, Giovanni, additional, Murphy, Maria M., additional, Oliveira, Lucia C., additional, Oliveira, Enio C., additional, Papagrigoriadis, Savvas, additional, Penna, Antonio, additional, Pietrzak, Anna, additional, Poskus, Tomas, additional, Reichert, Matthias, additional, Rodino', Stefano, additional, Regula, Jaroslaw, additional, Vassallo, Roberto, additional, and Walker, Marjorie M., additional

Published
2018
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199. Tu1311 - Effectiveness and Safety of Pylera ® in Patients Infected by Helicobacter Pylori : A Large, Prospective, Real Life Study

Author

Tursi, Antonio, primary, Franceschi, Marilisa, additional, Allegretta, Leonardo, additional, Savarino, Edoardo V., additional, De Bastiani, Rudi, additional, Elisei, Walter, additional, Penna, Antonio, additional, Pranzo, Giuseppe, additional, Cassieri, Claudio, additional, Brandimarte, Giovanni, additional, Picchio, Marcello, additional, Scida, Serena, additional, Miraglia, Chiara, additional, and Di Mario, Francesco, additional

Published
2018
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