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863 results on '"Tu, Yingfeng"'

156. Morphological Characteristics of Eroded Plaques with Noncritical Coronary Stenosis: An Optical Coherence Tomography Study

Author

Fang, Chao, primary, Lu, Jia, additional, Zhang, Shaotao, additional, Wang, Jifei, additional, Wang, Yidan, additional, Li, Lulu, additional, Wang, Yini, additional, Jiang, Senqing, additional, Yin, Yanwei, additional, Guo, Junchen, additional, Lei, Fangmeng, additional, Yu, Huai, additional, Wei, Guo, additional, Yao, Yuan, additional, Chen, Tao, additional, Ren, Xuefeng, additional, Xing, Lei, additional, Tu, Yingfeng, additional, Hou, Jingbo, additional, Dai, Jiannan, additional, and Yu, Bo, additional

Published
2021
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159. Discovery of Novel and Highly Potent Resorcinol Dibenzyl Ether-Based PD-1/PD-L1 Inhibitors with Improved Drug-like and Pharmacokinetic Properties for Cancer Treatment

Author

Cheng, Binbin, primary, Wang, Wei, additional, Niu, Xiaoge, additional, Ren, Yichang, additional, Liu, Ting, additional, Cao, Hao, additional, Wang, Shuanghu, additional, Tu, Yingfeng, additional, Chen, Jingxuan, additional, Liu, Shuwen, additional, Yang, Xuchao, additional, and Chen, Jianjun, additional

Published
2020
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163. Systemic and local factors associated with reduced thrombolysis in myocardial infarction flow in ST-segment elevation myocardial infarction patients with plaque erosion detected by intravascular optical coherence tomography

Author

Wang, Jifei, primary, Fang, Chao, additional, Zhang, Shaotao, additional, Li, Lulu, additional, Lu, Jia, additional, Wang, Yidan, additional, Wang, Yini, additional, Yu, Huai, additional, Wei, Guo, additional, Yin, Yanwei, additional, Jiang, Senqing, additional, Guo, Junchen, additional, Lei, Fangmeng, additional, Liu, Huimin, additional, Xu, Maoen, additional, Ren, Xuefeng, additional, Ma, Lijia, additional, Tu, Yingfeng, additional, Xing, Lei, additional, Hou, Jingbo, additional, Dai, Jiannan, additional, and Yu, Bo, additional

Published
2020
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169. Drug Delivery Systems: Hyperthermia‐Triggered On‐Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy (Adv. Sci. 11/2020)

Author

Gao, Junbin, primary, Wang, Fei, additional, Wang, Shuanghu, additional, Liu, Lu, additional, Liu, Kun, additional, Ye, Yicheng, additional, Wang, Zhen, additional, Wang, Hong, additional, Chen, Bin, additional, Jiang, Jiamiao, additional, Ou, Juanfeng, additional, Hest, Jan C. M., additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2020
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170. Hyperthermia‐Triggered On‐Demand Biomimetic Nanocarriers for Synergetic Photothermal and Chemotherapy

Author

Gao, Junbin, primary, Wang, Fei, additional, Wang, Shuanghu, additional, Liu, Lu, additional, Liu, Kun, additional, Ye, Yicheng, additional, Wang, Zhen, additional, Wang, Hong, additional, Chen, Bin, additional, Jiang, Jiamiao, additional, Ou, Juanfeng, additional, Hest, Jan C. M., additional, Peng, Fei, additional, and Tu, Yingfeng, additional

Published
2020
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177. Bone-Targeting Prodrug Mesoporous Silica-Based Nanoreactor with Reactive Oxygen Species Burst for Enhanced Chemotherapy

Author

Tong, Fei, Ye, Yicheng, Chen, Bin, Gao, Junbin, Liu, Lu, Ou, Juanfeng, van Hest, Jan C.M., Liu, Shuwen, Peng, Fei, Tu, Yingfeng, Tong, Fei, Ye, Yicheng, Chen, Bin, Gao, Junbin, Liu, Lu, Ou, Juanfeng, van Hest, Jan C.M., Liu, Shuwen, Peng, Fei, and Tu, Yingfeng

Abstract

Cancer remains a primary threat to human lives. Recently, amplification of tumor-associated reactive oxygen species (ROS) has been used as a boosting strategy to improve tumor therapy. Here, we report on a bone-targeting prodrug mesoporous silica-based nanoreactor for combined photodynamic therapy (PDT) and enhanced chemotherapy for osteosarcoma. Because of surface modification of a bone-targeting biphosphate moiety and the enhanced permeability and retention effect, the formed nanoreactor shows efficient accumulation in osteosarcoma and exhibits long-term retention in the tumor microenvironment. Upon laser irradiation, the loaded photosensitizer chlorin e6 (Ce6) produces in situ ROS, which not only works for PDT but also functions as a trigger for controlled release of doxorubicin (DOX) and doxycycline (DOXY) from the prodrugs based on a thioketal (TK) linkage. The released DOXY further promotes ROS production, thus perpetuating subsequent DOX/DOXY release and ROS burst. The ROS amplification induces long-term high oxidative stress, which increases the sensitivity of the osteosarcoma to chemotherapy, therefore resulting in enhanced tumor cell inhibition and apoptosis. The as-developed nanoreactor with combined PDT and enhanced chemotherapy based on ROS amplification shows significant promise as a potential platform for cancer treatment.

Published
2020

195. Pancoronary Plaque Characteristics in STEMI Caused by Culprit Plaque Erosion Versus Rupture: 3-Vessel OCT Study.

Author

Cao, Muhua, Zhao, Linlin, Ren, Xuefeng, Wu, Tianyu, Yang, Guang, Du, Zhuo, Yu, Huai, Dai, Jiannan, Li, Lulu, Wang, Yini, Wei, Guo, Ma, Lijia, Xing, Lei, Tu, Yingfeng, Fang, Shaohong, Tian, Jinwei, Jia, Haibo, Mintz, Gary S., and Yu, Bo

Abstract

This study sought to investigate nonculprit plaque characteristics in patients with ST-segment elevation myocardial infarction (STEMI) presenting with plaque erosion (PE) and plaque rupture (PR). Pancoronary vulnerability was considered at nonculprit sites: 1) the CLIMA (Relationship Between OCT Coronary Plaque Morphology and Clinical Outcome) study (NCT02883088) defined high-risk plaques with simultaneous presence of 4 optical coherence tomography (OCT) features (minimum lumen area <3.5 mm2; fibrous cap thickness [FCT] <75 μm; maximum lipid arc >180º; and macrophage accumulation); and 2) the presence of plaque ruptures or thin-cap fibroatheromas (TCFA). PE is a unique clinical entity associated with better outcomes than PR. There is limited evidence regarding pancoronary plaque characteristics of patients with culprit PE versus culprit PR. Between October 2016 and September 2018, 523 patients treated by 3-vessel OCT at the time of primary percutaneous intervention were included with 152 patients excluded from final analysis. Overall, 458 nonculprit plaques were identified in 202 STEMI patients with culprit PE; and 1,027 nonculprit plaques were identified in 321 STEMI patients with culprit PR. At least 1 CLIMA-defined OCT nonculprit high-risk plaque was seen in 11.4% of patients with culprit PE, but twice as many patients were seen with culprit PR (25.2%; p < 0.001). This proportion was also seen when individual high-risk features were analyzed separately. When patients with PE were divided by a heterogeneous substrate (fibrous or lipid-rich plaque) underlying the culprit site, the prevalence of nonculprits with FCT <75 μm, macrophages, and TCFA showed a significant gradient from PE (Fibrous) to PE lipid-rich plaque (LRP) to PR. Interestingly, nonculprit rupture was rarely found in patients with culprit PE (Fibrous) (1.9%), although it was exhibited with comparable prevalence in patients with culprit PE (LRP) (16.3%) versus PR (17.8%). Culprit PE predicted decreased pancoronary vulnerability independent of conventional risk factors. STEMI patients with culprit PE have a limited pancoronary vulnerability that may explain better outcomes in these patients than in STEMI patients with culprit PR. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2021
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197. Fuel-Free Micro-/Nanomotors as Intelligent Therapeutic Agents

Author

Liu, Lu, Gao, Junbin, Wilson, D.A., Tu, Yingfeng, Peng, Fei, Liu, Lu, Gao, Junbin, Wilson, D.A., Tu, Yingfeng, and Peng, Fei

Abstract

Contains fulltext : 214600.pdf (publisher's version ) (Closed access), There are many efficient biological motors in Nature that perform complex functions by converting chemical energy into mechanical motion. Inspired by this, the development of their synthetic counterparts has aroused tremendous research interest in the past decade. Among these man-made motor systems, the fuel-free (or light, magnet, ultrasound, or electric field driven) motors are advantageous in terms of controllability, lifespan, and biocompatibility concerning bioapplications, when compared with their chemically powered counterparts. Therefore, this review will highlight the latest biomedical applications in the versatile field of externally propelled micro-/nanomotors, as well as elucidating their driving mechanisms. A perspective into the future of the micro-/nanomotors field and a discussion of the challenges we need to face along the road towards practical clinical translation of external-field-propelled micro-/nanomotors will be provided.

Published
2019

198. Fabrication of Self-Propelled Micro- and Nanomotors Based on Janus Structures

Author

Ye, Yicheng, Luan, J., Wang, Ming, Chen, Yongming, Wilson, D.A., Peng, Fei, Tu, Yingfeng, Ye, Yicheng, Luan, J., Wang, Ming, Chen, Yongming, Wilson, D.A., Peng, Fei, and Tu, Yingfeng

Abstract

Contains fulltext : 214599.pdf (publisher's version ) (Closed access), Delicate molecular and biological motors are tiny machines capable of achieving numerous vital tasks in biological processes. To gain a deeper understanding of their mechanism of motion, researchers from multiple backgrounds have designed and fabricated artificial micro- and nanomotors. These nano-/microscale motors can self-propel in solution by exploiting different sources of energy; thus showing tremendous potential in widespread applications. As one of the most common motor systems, Janus motors possess unique asymmetric structures and integrate different functional materials onto two sides. This review mainly focuses on the fabrication of different types of micro- and nanomotors based on Janus structures. Furthermore, some challenges still exist in the implementation of Janus motors in the biomedical field. With such common goals in mind, it is expected that the elaborate and multifunctional design of Janus motors will overcome their challenges in the near future.

Published
2019

199. Nonequilibrium Reshaping of Polymersomes via Polymer Addition

Author

Men, Y., Li, Wei, Tu, Yingfeng, Peng, Fei, Janssen, G.J.A., Nolte, R.J.M., Wilson, Daniela A., Men, Y., Li, Wei, Tu, Yingfeng, Peng, Fei, Janssen, G.J.A., Nolte, R.J.M., and Wilson, Daniela A.

Abstract

Contains fulltext : 214402.pdf (publisher's version ) (Open Access)

Published
2019

200. Thermoresponsive Brushes Facilitate Effective Reinforcement of Calcium Phosphate Cements

Author

Petre, Daniela Geta (author), Nadar, Robin (author), Tu, Yingfeng (author), Paknahad, A. (author), Wilson, Daniela A. (author), Leeuwenburgh, Sander C.G. (author), Petre, Daniela Geta (author), Nadar, Robin (author), Tu, Yingfeng (author), Paknahad, A. (author), Wilson, Daniela A. (author), and Leeuwenburgh, Sander C.G. (author)

Abstract

Calcium phosphate ceramics are frequently applied to stimulate regeneration of bone in view of their excellent biological compatibility with bone tissue. Unfortunately, these bioceramics are also highly brittle. To improve their toughness, fibers can be incorporated as the reinforcing component for the calcium phosphate cements. Herein, we functionalize the surface of poly(vinyl alcohol) fibers with thermoresponsive poly(N-isopropylacrylamide) brushes of tunable thickness to improve simultaneously fiber dispersion and fiber-matrix affinity. These brushes shift from hydrophilic to hydrophobic behavior at temperatures above their lower critical solution temperature of 32 °C. This dual thermoresponsive shift favors fiber dispersion throughout the hydrophilic calcium phosphate cements (at 21 °C) and toughens these cements when reaching their hydrophobic state (at 37 °C). The reinforcement efficacy of these surface-modified fibers was almost double at 37 versus 21 °C, which confirms the strong potential of thermoresponsive fibers for reinforcement of calcium phosphate cements., Applied Mechanics

Published
2019
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