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772 results on '"Trusolino, Livio"'

151. Abstract 1397: Synthetic lethality screenings highlight colorectal cancer vulnerability to concomitant blockade of the NEDD8 and EGFR pathways

Author

Invrea, Federica, primary, Punzi, Simona, additional, Petti, Consalvo, additional, Minelli, Rosalba, additional, Peoples, Michael, additional, Bristow, Christopher, additional, Corrado, Alessia, additional, Vurchio, Valentina, additional, Trusolino, Livio, additional, Marchiò, Caterina, additional, Bardelli, Alberto, additional, Isella, Claudio, additional, Carugo, Alessandro, additional, Draetta, Giulio, additional, and Medico, Enzo, additional

Published
2021
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152. Abstract 1081: Genome-wide CRISPR screens reveal Hippo pathway activation as a resistance mechanism in BRAF mutant colon cancer

Author

Brammeld, Jonathan S., primary, Thorpe, Hannah, additional, Garcia, Mar Arias, additional, Price, Stacey, additional, Young, Jamie, additional, Pfeifer, Matthias, additional, Lupo, Barbara, additional, Yusa, Kosuke, additional, Trusolino, Livio, additional, Garnett, Mathew, additional, Bertotti, Andrea, additional, Bakal, Chris, additional, and McDermott, Ultan, additional

Published
2021
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153. Abstract 2358: miRNA-483-3p overexpression unleashes invasiveness of metastatic colorectal cancer by NDRG1 targeting and upregulation of the HER3-AKT axis

Author

Candiello, Ermes, primary, Reato, Gigliola, additional, Verginelli, Federica, additional, D'Ambrosio, Antonio, additional, Gambardella, Gennaro, additional, Albano, Raffaella, additional, Luraghi, Paolo, additional, Comoglio, Paolo M., additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, and Boccaccio, Carla, additional

Published
2021
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154. The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation

Author

Fiorito, Veronica, primary, Allocco, Anna Lucia, additional, Petrillo, Sara, additional, Gazzano, Elena, additional, Torretta, Simone, additional, Marchi, Saverio, additional, Destefanis, Francesca, additional, Pacelli, Consiglia, additional, Audrito, Valentina, additional, Provero, Paolo, additional, Medico, Enzo, additional, Chiabrando, Deborah, additional, Porporato, Paolo Ettore, additional, Cancelliere, Carlotta, additional, Bardelli, Alberto, additional, Trusolino, Livio, additional, Capitanio, Nazzareno, additional, Deaglio, Silvia, additional, Altruda, Fiorella, additional, Pinton, Paolo, additional, Cardaci, Simone, additional, Riganti, Chiara, additional, and Tolosano, Emanuela, additional

Published
2021
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155. Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Author

CMM Groep Snippert, Cancer, CMM Groep Bos, Hubrecht Institute with UMC, Ponsioen, Bas, Post, Jasmin B, Buissant des Amorie, Julian R, Laskaris, Dimitrios, van Ineveld, Ravian L, Kersten, Simone, Bertotti, Andrea, Sassi, Francesco, Sipieter, François, Cappe, Benjamin, Mertens, Sander, Verlaan-Klink, Ingrid, Boj, Sylvia F, Vries, Rob G J, Rehmann, Holger, Vandenabeele, Peter, Riquet, Franck B, Trusolino, Livio, Bos, Johannes L, Snippert, Hugo J G, CMM Groep Snippert, Cancer, CMM Groep Bos, Hubrecht Institute with UMC, Ponsioen, Bas, Post, Jasmin B, Buissant des Amorie, Julian R, Laskaris, Dimitrios, van Ineveld, Ravian L, Kersten, Simone, Bertotti, Andrea, Sassi, Francesco, Sipieter, François, Cappe, Benjamin, Mertens, Sander, Verlaan-Klink, Ingrid, Boj, Sylvia F, Vries, Rob G J, Rehmann, Holger, Vandenabeele, Peter, Riquet, Franck B, Trusolino, Livio, Bos, Johannes L, and Snippert, Hugo J G

Published
2021

157. Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice

Author

Casazza, Andrea, Finisguerra, Veronica, Capparuccia, Lorena, Camperi, Andrea, Swiercz, Jakub M., Rizzolio, Sabrina, Rolny, Charlotte, Christensen, Claus, Bertotti, Andrea, Sarotto, Ivana, Risio, Mauro, Trusolino, Livio, Weitz, Jurgen, Schneider, Martin, Mazzone, Massimilano, Comoglio, Paolo M., and Tamagnone, Luca

Subjects
Cancer invasiveness -- Development and progression -- Genetic aspects, Metastasis -- Development and progression -- Genetic aspects, Cellular signal transduction -- Genetic aspects, Cancer cells -- Genetic aspects, Semaphorins -- Properties -- Genetic aspects, Health care industry
Abstract

Semaphorin 3E (Sema3E) is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Sema3E is also highly expressed in metastatic cancer cells, but its mechanistic role in tumor progression was not understood. Here we show that expression of Sema3E and its receptor Plexin D1 correlates with the metastatic progression of human tumors. Consistent with the clinical data, knocking down endogenous expression of either Sema3E or Plexin D1 in human metastatic carcinoma cells hampered their metastatic potential when injected into mice, while tumor growth was not markedly affected. Conversely, overexpression of exogenous Sema3E in cancer cells increased their invasiveness, transendothelial migration, and metastatic spreading, although it inhibited tumor vessel formation, resulting in reduced tumor growth in mice. The proinvasive and metastatic activity of Sema3E in tumor cells was dependent on transactivation of the Plexin D1-associated ErbB2/Neu oncogenic kinase. In sum, Sema3E-Plexin D1 signaling in cancer cells is crucially implicated in their metastatic behavior and may therefore be a promising target for strategies aimed at blocking tumor metastasis., Introduction Semaphorins are secreted and membrane-bound signals, originally implicated in the control of axonal wiring (1). They comprise a wide protein family and are involved in a range of functions, [...]

Published
2010
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159. MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients

Author

Rocci, Alberto, Gambella, Manuela, Aschero, Simona, Baldi, Ileana, Trusolino, Livio, Cavallo, Federica, Gay, Francesca, Larocca, Alessandra, Magarotto, Valeria, Omedè, Paola, Isaia, Gianluca, Bertotti, Andrea, Liberati, Anna M., Catalano, Lucio, De Rosa, Luca, Musto, Pellegrino, Vallone, Roberto, Falcone, Antonietta, Drandi, Daniela, Ladetto, Marco, Comoglio, Paolo M., Boccadoro, Mario, and Palumbo, Antonio

Published
2014
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160. Towards precision oncology with patient-derived xenografts

Author

Zanella, Eugenia R., Grassi, Elena, and Trusolino, Livio

Abstract

Under the selective pressure of therapy, tumours dynamically evolve multiple adaptive mechanisms that make static interrogation of genomic alterations insufficient to guide treatment decisions. Clinical research does not enable the assessment of how various regulatory circuits in tumours are affected by therapeutic insults over time and space. Likewise, testing different precision oncology approaches informed by composite and ever-changing molecular information is hard to achieve in patients. Therefore, preclinical models that incorporate the biology and genetics of human cancers, facilitate analyses of complex variables and enable adequate population throughput are needed to pinpoint randomly distributed response predictors. Patient-derived xenograft (PDX) models are dynamic entities in which cancer evolution can be monitored through serial propagation in mice. PDX models can also recapitulate interpatient diversity, thus enabling the identification of response biomarkers and therapeutic targets for molecularly defined tumour subgroups. In this Review, we discuss examples from the past decade of the use of PDX models for precision oncology, from translational research to drug discovery. We elaborate on how and to what extent preclinical observations in PDX models have confirmed and/or anticipated findings in patients. Finally, we illustrate emerging methodological efforts that could broaden the application of PDX models by honing their predictive accuracy or improving their versatility.

Published
2022
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164. Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Author

Ponsioen, Bas, primary, Post, Jasmin B., additional, Buissant des Amorie, Julian R., additional, Laskaris, Dimitrios, additional, van Ineveld, Ravian L., additional, Kersten, Simone, additional, Bertotti, Andrea, additional, Sassi, Francesco, additional, Sipieter, François, additional, Cappe, Benjamin, additional, Mertens, Sander, additional, Verlaan-Klink, Ingrid, additional, Boj, Sylvia F., additional, Vries, Rob G. J., additional, Rehmann, Holger, additional, Vandenabeele, Peter, additional, Riquet, Franck B., additional, Trusolino, Livio, additional, Bos, Johannes L., additional, and Snippert, Hugo J. G., additional

Published
2021
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166. EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, V., Yaeger, R., Arcella, P., Cancelliere, C., Lamba, S., Lorenzato, A., Arena, S., Montone, M., Mussolin, B., Bian, Y., Whaley, A., Pinnelli, M., Murciano-Goroff, Y. R., Vakiani, E., Valeri, N., Liao, W. L., Bhalkikar, A., Thyparambil, S., Zhao, H. Y., de Stanchina, E., Marsoni, S., Siena, S., Bertotti, A., Trusolino, Livio, Li, B. T., Rosen, N., Di Nicolantonio, F., Bardelli, A., and Misale, S.

Abstract

Most patients withKRASG12C–mutant non–small cell lung cancer (NSCLC) experience clinical benefit from selective KRASG12Cinhibition, whereas patients with colorectal cancer bearing the same mutation rarely respond. To investigate the cause of the limited efficacy of KRASG12Cinhibitors in colorectal cancer, we examined the effects of AMG510 inKRASG12Ccolorectal cancer cell lines. Unlike NSCLC cell lines,KRASG12Ccolorectal cancer models have high basal receptor tyrosine kinase (RTK) activation and are responsive to growth factor stimulation. In colorectal cancer lines, KRASG12Cinhibition induces higher phospho-ERK rebound than in NSCLC cells. Although upstream activation of several RTKs interferes with KRASG12Cblockade, we identify EGFR signaling as the dominant mechanism of colorectal cancer resistance to KRASG12Cinhibitors. The combinatorial targeting of EGFR and KRASG12Cis highly effective in colorectal cancer cells and patient-derived organoids and xenografts, suggesting a novel therapeutic strategy to treat patients withKRASG12Ccolorectal cancer. Significance: The efficacy of KRASG12Cinhibitors in NSCLC and colorectal cancer is lineage-specific. RTK dependency and signaling rebound kinetics are responsible for sensitivity or resistance to KRASG12Cinhibition in colorectal cancer. EGFR and KRASG12Cshould be concomitantly inhibited to overcome resistance to KRASG12Cblockade in colorectal tumors.

Published
2020

167. Innovations, challenges, and minimal information for standardization of humanized mice

Author

Stripecke, Renata, Muenz, Christian, Schuringa, Jan Jacob, Bissig, Karl-Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li-Chin, Di Santo, James P., Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E., Kitchen, Scott, Klein, Florian, Saeb-Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas, Trusolino, Livio, Bult, Carol, Shultz, Leonard, Stripecke, Renata, Muenz, Christian, Schuringa, Jan Jacob, Bissig, Karl-Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li-Chin, Di Santo, James P., Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E., Kitchen, Scott, Klein, Florian, Saeb-Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas, Trusolino, Livio, Bult, Carol, and Shultz, Leonard

Abstract

Mice xenotransplanted with human cells and/or expressing human gene products (also known as humanized mice) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevantin vivocontext for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community-driven resource called Minimal Information for Standardization of Humanized Mice (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. WithinMISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.

Published
2020

168. Innovations, challenges, and minimal information for standardization of humanized mice

Author

Stripecke, Renata; https://orcid.org/0000-0001-7756-8460, Münz, Christian; https://orcid.org/0000-0001-6419-1940, Schuringa, Jan Jacob; https://orcid.org/0000-0001-8452-8555, Bissig, Karl‐Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li‐Chin, Di Santo, James P, Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E, Kitchen, Scott, Klein, Florian, Saeb‐Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas; https://orcid.org/0000-0002-6212-3466, Trusolino, Livio, Bult, Carol, Shultz, Leonard, Stripecke, Renata; https://orcid.org/0000-0001-7756-8460, Münz, Christian; https://orcid.org/0000-0001-6419-1940, Schuringa, Jan Jacob; https://orcid.org/0000-0001-8452-8555, Bissig, Karl‐Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li‐Chin, Di Santo, James P, Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E, Kitchen, Scott, Klein, Florian, Saeb‐Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas; https://orcid.org/0000-0002-6212-3466, Trusolino, Livio, Bult, Carol, and Shultz, Leonard

Abstract

Mice xenotransplanted with human cells and/or expressing human gene products (also known as "humanized mice") recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo context for understanding of human-specific physiology and pathologies. Humanized mice have advanced toward mainstream preclinical models and are now at the forefront of biomedical research. Here, we considered innovations and challenges regarding the reconstitution of human immunity and human tissues, modeling of human infections and cancer, and the use of humanized mice for testing drugs or regenerative therapy products. As the number of publications exploring different facets of humanized mouse models has steadily increased in past years, it is becoming evident that standardized reporting is needed in the field. Therefore, an international community-driven resource called "Minimal Information for Standardization of Humanized Mice" (MISHUM) has been created for the purpose of enhancing rigor and reproducibility of studies in the field. Within MISHUM, we propose comprehensive guidelines for reporting critical information generated using humanized mice.

Published
2020

169. [beta]4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth

Author

Bertotti, Andrea, Comoglio, Paolo M., and Trusolino, Livio

Subjects
Enzymes -- Chemical properties, RNA -- Genetic aspects, Biological sciences
Abstract

Despite being a cell-matrix adhesion molecule, [beta]4 integrin can prompt the multiplication of neoplastic cells dislodged from their substrates (anchorage-independent growth). However, the molecular events underlying this atypical behavior remain partly unexplored. We found that activation of the Met receptor for hepatocyte growth factor results in the tyrosine phosphorylation of [beta]4, which is instrumental for integrin-mediated recruitment of the tyrosine phosphatase Shp2. Shp2 binding to [beta]4 enhances the activation of Src, which, in turn, phosphorylates the multiadaptor Gab1 predominantly on consensus sites for Grb2 association, leading to privileged stimulation of the Ras-extracellular signal-regulated kinase (ERK) cascade. This signaling axis can be inhibited by small interfering RNA-mediated [beta]4 depletion, by a [beta]4 mutant unable to bind Shp2, and by pharmacological and genetic inhibition of Shp2 or Src. Preservation of the [beta]4 docking sites for Shp2 as well as the integrity of Shp2, Src, or ERK activity are required for the [beta]4-mediated induction of anchorage-independent growth. These results unravel a novel pathway whereby [beta]4 directs tyrosine kinase-based signals toward adhesion-unrelated outcomes.

Published
2006

170. Cancer: the matrix is now in control

Author

Comoglio, Paolo M and Trusolino, Livio

Abstract

Author(s): Paolo M Comoglio [1]; Livio Trusolino [1] The extracellular matrix (ECM) is a complex molecular milieu that provides cells with the tensile scaffold necessary for appropriate assembly into three-dimensional [...]

Published
2005
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171. Long-term Clinical Outcome of Trastuzumab and Lapatinib for HER2-positive Metastatic Colorectal Cancer

Author

Tosi, Federica, primary, Sartore-Bianchi, Andrea, additional, Lonardi, Sara, additional, Amatu, Alessio, additional, Leone, Francesco, additional, Ghezzi, Silvia, additional, Martino, Cosimo, additional, Bencardino, Katia, additional, Bonazzina, Erica, additional, Bergamo, Francesca, additional, Fenocchio, Elisabetta, additional, Martinelli, Erika, additional, Troiani, Teresa, additional, Siravegna, Giulia, additional, Mauri, Gianluca, additional, Torri, Valter, additional, Marrapese, Giovanna, additional, Valtorta, Emanuele, additional, Cassingena, Andrea, additional, Cappello, Giovanni, additional, Bonoldi, Emanuela, additional, Vanzulli, Angelo, additional, Regge, Daniele, additional, Ciardiello, Fortunato, additional, Zagonel, Vittorina, additional, Bardelli, Alberto, additional, Trusolino, Livio, additional, Marsoni, Silvia, additional, and Siena, Salvatore, additional

Published
2020
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172. Intratumoral Transcriptome Heterogeneity Is Associated With Patient Prognosis and Sidedness in Patients With Colorectal Cancer Treated With Anti-EGFR Therapy From the CO.20 Trial

Author

Fontana, Elisa, primary, Nyamundanda, Gift, additional, Cunningham, David, additional, Tu, Dongsheng, additional, Cheang, Maggie C.U., additional, Jonker, Derek J., additional, Siu, Lillian L., additional, Sclafani, Francesco, additional, Eason, Katherine, additional, Ragulan, Chanthirika, additional, Bali, Maria Antonietta, additional, Hulkki-Wilson, Sanna, additional, Loree, Jonathan M., additional, Waring, Paul M., additional, Giordano, Mirella, additional, Lawrence, Patrick, additional, Rodrigues, Daniel Nava, additional, Begum, Ruwaida, additional, Shapiro, Jeremy D., additional, Price, Timothy J., additional, Cremolini, Chiara, additional, Starling, Naureen, additional, Pietrantonio, Filippo, additional, Trusolino, Livio, additional, O’Callaghan, Christopher J., additional, and Sadanandam, Anguraj, additional

Published
2020
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175. Chromatin Velocity reveals epigenetic dynamics by single-cell profiling of heterochromatin and euchromatin.

Author

Tedesco, Martina, Giannese, Francesca, Lazarević, Dejan, Giansanti, Valentina, Rosano, Dalia, Monzani, Silvia, Catalano, Irene, Grassi, Elena, Zanella, Eugenia R., Botrugno, Oronza A., Morelli, Leonardo, Panina Bordignon, Paola, Caravagna, Giulio, Bertotti, Andrea, Martino, Gianvito, Aldrighetti, Luca, Pasqualato, Sebastiano, Trusolino, Livio, Cittaro, Davide, and Tonon, Giovanni

Abstract

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-throughput, single-cell assessment of heterochromatin and its underlying genomic determinants remains challenging. We engineered a hybrid transposase including the chromodomain (CD) of the heterochromatin protein-1α (HP-1α), which is involved in heterochromatin assembly and maintenance through its binding to trimethylation of the lysine 9 on histone 3 (H3K9me3), and developed a single-cell method, single-cell genome and epigenome by transposases sequencing (scGET-seq), that, unlike single-cell assay for transposase-accessible chromatin with sequencing (scATAC-seq), comprehensively probes both open and closed chromatin and concomitantly records the underlying genomic sequences. We tested scGET-seq in cancer-derived organoids and human-derived xenograft (PDX) models and identified genetic events and plasticity-driven mechanisms contributing to cancer drug resistance. Next, building upon the differential enrichment of closed and open chromatin, we devised a method, Chromatin Velocity, that identifies the trajectories of epigenetic modifications at the single-cell level. Chromatin Velocity uncovered paths of epigenetic reorganization during stem cell reprogramming and identified key transcription factors driving these developmental processes. scGET-seq reveals the dynamics of genomic and epigenetic landscapes underlying any cellular processes. Single-cell mapping of heterochromatin and euchromatin using chromatin velocity defines trajectories of epigenetic modifications. [ABSTRACT FROM AUTHOR]

Published
2022
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177. A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth

Author

Trusolino, Livio, Bertotti, Andrea, and Comogilio, Paolo M.

Subjects
Integrins -- Physiological aspects, Cancer invasiveness -- Physiological aspects, Protein tyrosine kinase -- Physiological aspects, Cellular signal transduction -- Physiological aspects, Biological sciences
Abstract

Research shows that tyrosine phosphorylated alpha6beta4 integrin combines with adapter protein Shc and P13K leading to hepatocyte growth factor-triggered activation of Ras- and P13K-dependent pathways. Data suggest that the integrin helps cancer invasion by amplifying biochemical responses.

Published
2001

179. Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models

Author

O’Farrell, Alice C., primary, Jarzabek, Monika A., additional, Lindner, Andreas U., additional, Carberry, Steven, additional, Conroy, Emer, additional, Miller, Ian S., additional, Connor, Kate, additional, Shiels, Liam, additional, Zanella, Eugenia R., additional, Lucantoni, Federico, additional, Lafferty, Adam, additional, White, Kieron, additional, Meyer Villamandos, Mariangela, additional, Dicker, Patrick, additional, Gallagher, William M., additional, Keek, Simon A., additional, Sanduleanu, Sebastian, additional, Lambin, Philippe, additional, Woodruff, Henry C., additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, Byrne, Annette T., additional, and Prehn, Jochen H. M., additional

Published
2020
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180. Systems analysis of protein signatures predicting cetuximab responses inKRAS,NRAS,BRAFandPIK3CAwild‐type patient‐derived xenograft models of metastatic colorectal cancer

Author

Lindner, Andreas U., primary, Carberry, Steven, additional, Monsefi, Naser, additional, Barat, Ana, additional, Salvucci, Manuela, additional, O'Byrne, Robert, additional, Zanella, Eugenia R., additional, Cremona, Mattia, additional, Hennessy, Bryan T., additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, and Prehn, Jochen H. M., additional

Published
2020
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181. Abstract CT263: Post-surgical liquid biopsy-guided treatment of stage III and high-risk stage II colon cancer patients: The PEGASUS trial

Author

Elez, Elena, primary, Pietrantonio, Filippo, additional, Sartore-Bianchi, Andrea, additional, Montagut, Clara, additional, Cervantes, Andres, additional, Sciallero, Stefania, additional, Zampino, Maria Giulia, additional, Mosconi, Stefania, additional, Torri, Valter, additional, Tarazona, Noelia, additional, Lazzari, Luca, additional, Luraghi, Paolo, additional, Muñoz, Susana, additional, Fassan, Matteo, additional, Medico, Enzo, additional, Trusolino, Livio, additional, Rescigno, Maria, additional, Siena, Salvatore, additional, Sobrero, Alberto, additional, Labianca, Roberto, additional, Tabernero, Josep, additional, Bardelli, Alberto, additional, Lonardi, Sara, additional, and Marsoni, Silvia, additional

Published
2020
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182. Colorectal cancer residual disease at maximal response to EGFR blockade displays a druggable Paneth cell–like phenotype

Author

Lupo, Barbara, primary, Sassi, Francesco, additional, Pinnelli, Marika, additional, Galimi, Francesco, additional, Zanella, Eugenia R., additional, Vurchio, Valentina, additional, Migliardi, Giorgia, additional, Gagliardi, Paolo Armando, additional, Puliafito, Alberto, additional, Manganaro, Daria, additional, Luraghi, Paolo, additional, Kragh, Michael, additional, Pedersen, Mikkel W., additional, Horak, Ivan D., additional, Boccaccio, Carla, additional, Medico, Enzo, additional, Primo, Luca, additional, Nichol, Daniel, additional, Spiteri, Inmaculada, additional, Heide, Timon, additional, Vatsiou, Alexandra, additional, Graham, Trevor A., additional, Élez, Elena, additional, Argiles, Guillem, additional, Nuciforo, Paolo, additional, Sottoriva, Andrea, additional, Dienstmann, Rodrigo, additional, Pasini, Diego, additional, Grassi, Elena, additional, Isella, Claudio, additional, Bertotti, Andrea, additional, and Trusolino, Livio, additional

Published
2020
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183. EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, additional, Arcella, Pamela, additional, Cancelliere, Carlotta, additional, Lamba, Simona, additional, Lorenzato, Annalisa, additional, Arena, Sabrina, additional, Montone, Monica, additional, Mussolin, Benedetta, additional, Bian, Yu, additional, Whaley, Adele, additional, Pinnelli, Marika, additional, Murciano-Goroff, Yonina R., additional, Vakiani, Efsevia, additional, Valeri, Nicola, additional, Liao, Wei-Li, additional, Bhalkikar, Anuja, additional, Thyparambil, Sheeno, additional, Zhao, Hui-Yong, additional, de Stanchina, Elisa, additional, Marsoni, Silvia, additional, Siena, Salvatore, additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, Li, Bob T., additional, Rosen, Neal, additional, Di Nicolantonio, Federica, additional, Bardelli, Alberto, additional, and Misale, Sandra, additional

Published
2020
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184. Innovations, challenges, and minimal information for standardization of humanized mice

Author

Stripecke, Renata, primary, Münz, Christian, additional, Schuringa, Jan Jacob, additional, Bissig, Karl‐Dimiter, additional, Soper, Brian, additional, Meeham, Terrence, additional, Yao, Li‐Chin, additional, Di Santo, James P, additional, Brehm, Michael, additional, Rodriguez, Estefania, additional, Wege, Anja Kathrin, additional, Bonnet, Dominique, additional, Guionaud, Silvia, additional, Howard, Kristina E, additional, Kitchen, Scott, additional, Klein, Florian, additional, Saeb‐Parsy, Kourosh, additional, Sam, Johannes, additional, Sharma, Amar Deep, additional, Trumpp, Andreas, additional, Trusolino, Livio, additional, Bult, Carol, additional, and Shultz, Leonard, additional

Published
2020
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185. Vitamin C Restricts the Emergence of Acquired Resistance to EGFR-Targeted Therapies in Colorectal Cancer

Author

Lorenzato, Annalisa, primary, Magrì, Alessandro, additional, Matafora, Vittoria, additional, Audrito, Valentina, additional, Arcella, Pamela, additional, Lazzari, Luca, additional, Montone, Monica, additional, Lamba, Simona, additional, Deaglio, Silvia, additional, Siena, Salvatore, additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, Bachi, Angela, additional, Di Nicolantonio, Federica, additional, Bardelli, Alberto, additional, and Arena, Sabrina, additional

Published
2020
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186. Pertuzumab and trastuzumab emtansine in patients with HER2-amplified metastatic colorectal cancer: the phase II HERACLES-B trial

Author

Sartore-Bianchi, Andrea, primary, Lonardi, Sara, additional, Martino, Cosimo, additional, Fenocchio, Elisabetta, additional, Tosi, Federica, additional, Ghezzi, Silvia, additional, Leone, Francesco, additional, Bergamo, Francesca, additional, Zagonel, Vittorina, additional, Ciardiello, Fortunato, additional, Ardizzoni, Andrea, additional, Amatu, Alessio, additional, Bencardino, Katia, additional, Valtorta, Emanuele, additional, Grassi, Elena, additional, Torri, Valter, additional, Bonoldi, Emanuela, additional, Sapino, Anna, additional, Vanzulli, Angelo, additional, Regge, Daniele, additional, Cappello, Giovanni, additional, Bardelli, Alberto, additional, Trusolino, Livio, additional, Marsoni, Silvia, additional, and Siena, Salvatore, additional

Published
2020
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187. Adaptive mutability of colorectal cancers in response to targeted therapies

Author

Russo, Mariangela, primary, Crisafulli, Giovanni, additional, Sogari, Alberto, additional, Reilly, Nicole M., additional, Arena, Sabrina, additional, Lamba, Simona, additional, Bartolini, Alice, additional, Amodio, Vito, additional, Magrì, Alessandro, additional, Novara, Luca, additional, Sarotto, Ivana, additional, Nagel, Zachary D., additional, Piett, Cortt G., additional, Amatu, Alessio, additional, Sartore-Bianchi, Andrea, additional, Siena, Salvatore, additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, Corigliano, Mattia, additional, Gherardi, Marco, additional, Lagomarsino, Marco Cosentino, additional, Di Nicolantonio, Federica, additional, and Bardelli, Alberto, additional

Published
2019
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188. Abstract A120: Adaptive mutability of colorectal cancers in response to targeted therapies

Author

RUSSO, MARIANGELA, primary, Crisafulli, Giovanni, additional, Sogari, Alberto, additional, Reilly, Nicole Megan, additional, Arena, Sabrina, additional, Lamba, Simona, additional, Bartolini, Alice, additional, Amodio, Vito, additional, Magrì, Alessandro, additional, Novara, Luca, additional, Sarotto, Ivana, additional, Nagel, Zachary, additional, Piett, Cortt, additional, Amatu, Alessio, additional, Sartore-Bianchi, Andrea, additional, Siena, Salvatore, additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, Nicolantonio, Federica Di, additional, and Bardelli, Alberto, additional

Published
2019
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190. INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases (vol 15, e8250, 2019)

Author

Beekhof, Robin, van Alphen, Carolien, Henneman, Alex A., Knol, Jaco C., Pham, Thang V., Rolfs, Frank, Labots, Mariette, Henneberry, Evan, Le Large, Tessa Y. S., de Haas, Richard R., Piersma, Sander R., Vurchio, Valentina, Bertotti, Andrea, Trusolino, Livio, Verheul, Henk M. W., Jimenez, Connie R., Medical oncology laboratory, Hematology laboratory, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Internal medicine, CCA - Cancer Treatment and quality of life, Surgery, Amsterdam Neuroscience - Neurodegeneration, and AGEM - Re-generation and cancer of the digestive system

Published
2019

191. Correction to: INKA, an integrative data analysis pipeline for phosphoproteomic inference of active kinases (Molecular Systems Biology, (2019), 15, 4, (e8250), 10.15252/msb.20188250)

Author

Beekhof, Robin, van Alphen, Carolien, Henneman, Alex A., Knol, Jaco C., Pham, Thang V., Rolfs, Frank, Labots, Mariette, Henneberry, Evan, le Large, Tessa Y. S., de Haas, Richard R., Piersma, Sander R., Vurchio, Valentina, Bertotti, Andrea, Trusolino, Livio, Verheul, Henk M. W., Jimenez, Connie R., Medical oncology laboratory, Hematology laboratory, CCA - Imaging and biomarkers, Medical oncology, Surgery, AGEM - Re-generation and cancer of the digestive system, and Amsterdam Neuroscience - Neurodegeneration

Abstract

The authors recently noticed that the affiliations for Valentina Vurchio, Andrea Bertotti, and Livio Trusolino were listed incorrectly. The correct author affiliation is shown here and has been corrected in the original article. The authors apologize for this error.

Published
2019

192. Additional file 2: of Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

Author

Belli, Valentina, Matrone, Nunzia, Napolitano, Stefania, Migliardi, Giorgia, Cottino, Francesca, Bertotti, Andrea, Trusolino, Livio, Martinelli, Erika, Morgillo, Floriana, Ciardiello, Davide, Falco, Vincenzo De, Giunta, Emilio, Bracale, Umberto, Ciardiello, Fortunato, and Troiani, Teresa

Subjects
skin and connective tissue diseases, neoplasms
Abstract

Table S1. Evaluation of protein expression level in parental (SW48 and LIM1215) and in HER2-amplified human colon cancer cell lines. Legend: Negative symbol (-) no protein expression detected; Positive symbols: (+) expression and (++) over-expression levels of each protein detected. Table S2. Antitumor efficacy of oxaliplatin plus trastuzumab followed by maintenance treatment in human HER2-amplified colon cancer xenograft. (DOCX 613 kb)

Published
2019
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193. Additional file 3: of Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models

Author

Belli, Valentina, Matrone, Nunzia, Napolitano, Stefania, Migliardi, Giorgia, Cottino, Francesca, Bertotti, Andrea, Trusolino, Livio, Martinelli, Erika, Morgillo, Floriana, Ciardiello, Davide, Falco, Vincenzo De, Giunta, Emilio, Bracale, Umberto, Ciardiello, Fortunato, and Troiani, Teresa

Abstract

Supplementary Methods. (DOCX 18 kb)

Published
2019
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194. Growth factor-dependent activation of alpha-v-beta-3 integrin in normal epithelial cells: implications for tumor invasion

Author

Trusolino, Livio, Serini, Guido, Cecchini, Germana, Besati, Cristina, Ambesi-Impiombato, Francesco Saverio, Marchisio, Pier Carlo, and De Filippi, Rosaria

Subjects
Tumors -- Research, Epithelial cells -- Research, Transforming growth factors -- Research, Biological sciences
Abstract

Research was conducted to demonstrate that the alpha-v-beta-3 integrin is expressed by normal cells in a latent state characterized by its inability to form cytoskeletal connections and to promote cell adhesion to extracellular matrix ligands. A cellular system of human thyroid clones was used to investigate the influence of cytokines on nonfunctional epithelial integrins. Results indicate the importance of cytokine-based autocrine loops for the physiological regulation of integrin activation.

Published
1998

196. Effective drug combinations in breast, colon and pancreatic cancer cells

Author

Jaaks, Patricia, Coker, Elizabeth A., Vis, Daniel J., Edwards, Olivia, Carpenter, Emma F., Leto, Simonetta M., Dwane, Lisa, Sassi, Francesco, Lightfoot, Howard, Barthorpe, Syd, van der Meer, Dieudonne, Yang, Wanjuan, Beck, Alexandra, Mironenko, Tatiana, Hall, Caitlin, Hall, James, Mali, Iman, Richardson, Laura, Tolley, Charlotte, Morris, James, Thomas, Frances, Lleshi, Ermira, Aben, Nanne, Benes, Cyril H., Bertotti, Andrea, Trusolino, Livio, Wessels, Lodewyk, and Garnett, Mathew J.

Abstract

Combinations of anti-cancer drugs can overcome resistance and provide new treatments1,2. The number of possible drug combinations vastly exceeds what could be tested clinically. Efforts to systematically identify active combinations and the tissues and molecular contexts in which they are most effective could accelerate the development of combination treatments. Here we evaluate the potency and efficacy of 2,025 clinically relevant two-drug combinations, generating a dataset encompassing 125 molecularly characterized breast, colorectal and pancreatic cancer cell lines. We show that synergy between drugs is rare and highly context-dependent, and that combinations of targeted agents are most likely to be synergistic. We incorporate multi-omic molecular features to identify combination biomarkers and specify synergistic drug combinations and their active contexts, including in basal-like breast cancer, and microsatellite-stable or KRAS-mutant colon cancer. Our results show that irinotecan and CHEK1 inhibition have synergistic effects in microsatellite-stable or KRAS–TP53double-mutant colon cancer cells, leading to apoptosis and suppression of tumour xenograft growth. This study identifies clinically relevant effective drug combinations in distinct molecular subpopulations and is a resource to guide rational efforts to develop combinatorial drug treatments.

Published
2022
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199. Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Author

Lazzari, Luca, primary, Corti, Giorgio, additional, Picco, Gabriele, additional, Isella, Claudio, additional, Montone, Monica, additional, Arcella, Pamela, additional, Durinikova, Erika, additional, Zanella, Eugenia R., additional, Novara, Luca, additional, Barbosa, Fabiane, additional, Cassingena, Andrea, additional, Cancelliere, Carlotta, additional, Medico, Enzo, additional, Sartore-Bianchi, Andrea, additional, Siena, Salvatore, additional, Garnett, Mathew J., additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, Di Nicolantonio, Federica, additional, Linnebacher, Michael, additional, Bardelli, Alberto, additional, and Arena, Sabrina, additional

Published
2019
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200. Abstract LB-299: A comprehensive platform of patient-derived xenografts and matched cell lines mirrors the genomic landscape of colorectal cancer

Author

Lazzari, Luca, primary, Corti, Giorgio, additional, Isella, Claudio, additional, Montone, Monica, additional, Arcella, Pamela, additional, Zanella, Eugenia, additional, Novara, Luca, additional, Barbosa, Fabiane, additional, Cassingena, Andrea, additional, Cancelliere, Carlotta, additional, Medico, Enzo, additional, Sartore-Bianchi, Andrea, additional, Siena, Salvatore, additional, Bertotti, Andrea, additional, Trusolino, Livio, additional, Nicolantonio, Federica Di, additional, Linnebacher, Michael, additional, Bardelli, Alberto, additional, and Arena, Sabrina, additional

Published
2019
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