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1,182 results on '"Trucco, Massimo"'

151. Bone marrow augmentation of donor-cell chimerism in kidney, liver, heart, and pancreas islet transplantation

Author

Fontes, Paulo, Rao, Abdul S., Demetris, Anthony J., Zeevi, Adriana, Trucco, Massimo, Carroll, Pat, Rybka, Witold, Rudert, William A., Ricordi, Camillo, Dodson, Forrest, Shapiro, Ron, Tzakis, Andreas, Todu, Satoru, Abu-Elmagd, Kareem, Jordan, Mark, Fung, John J., and Starzl, Thomas E.

Subjects
Transplantation of organs, tissues, etc. -- Physiological aspects, Bone marrow cells -- Health aspects, Leukocytes -- Physiological aspects
Published
1994

157. Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation

Author

Starzl, Thomas E., Demetris, Anthony J., Murase, Noriko, Thomson, Angus W., Trucco, Massimo, and Ricordi, Camillo

Subjects
Immunosuppressive agents -- Health aspects, Graft rejection -- Drug therapy, Biological sciences, Chemistry, Pharmaceuticals and cosmetics industries
Abstract

One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.

Published
1993

158. Chimerism after liver transplantation for type IV glycogen storage disease and type I Gaucher's disease

Author

Starzl, Thomas E., Demetris, Anthony J., Trucco, Massimo, Ricordi, Camillo, Ildstad, Suzanne, Terasaki, Paul I., Murase, Noriko, Kendall, Ross S., Kocova, Mirjana, Rudert, William A., Zeevi, Adriana, and Thiel, David van

Subjects
Liver -- Transplantation, Gaucher's disease -- Physiological aspects, Glycogenosis -- Physiological aspects, Transplantation of organs, tissues, etc. -- Physiological aspects
Abstract

The migration of cells from a transplanted liver into the recipient's tissues could correct several metabolic disorders caused by enzyme deficiencies. The migration of cells between a donor organ and the recipient's tissues has been called chimerism. In two patients with type IV glycogen storage disease, amylopectin deposits in the heart - a characteristic of the disease - had almost completely vanished three to five years after they received a liver transplant. DNA hybridization showed that both patients had cells from the donated liver in their hearts. A patient with type I Gaucher's disease also received a liver transplant. This disease is characterized by deposits of glucocerebroside in various organs. A lymph-node biopsy two years after transplantation revealed that cerebroside deposits had decreased. The biopsy also showed that his lymph nodes contained cells from the donated liver. Cells from donated organs could supply enzymes to correct metabolic deficiencies.

Published
1993

161. Cell migration, chimerism, and graft acceptance

Author

Starzl, Thomas E., Demetris, Anthony J., Murase, Noriko, Ildstad, Suzanne, Ricordi, Camillo, and Trucco, Massimo

Subjects
Cell migration -- Physiological aspects, Transplantation of organs, tissues, etc. -- Physiological aspects
Published
1992

166. Tolerogenic immunosuppression for organ transplantation

Author

Starzl, Thomas E, Murase, Noriko, Abu-Elmagd, Kareem, Gray, Edward A, Shapiro, Ron, Eghtesad, Bijan, Corry, Robert J, Jordan, Mark L, Fontes, Paulo, Gayowski, Tim, Bond, Geoffrey, Scantlebury, Velma P, Potdar, Santosh, Randhawa, Parmjeet, Adriana Zeevi, Tong Wu, Nalesnik, Michael A, Woodward, Jennifer, Marcos, Amadeo, Trucco, Massimo, Demetris, Anthony J, and Fung, John J

Published
2003
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185. The changing immunology of organ transplantation

Author

Starzl, Thomas E., Demetris, Anthony J., Murase, Noriko, Trucco, Massimo, Thomson, Angus W., and Rao, Abdul S.

Subjects
Transplantation of organs, tissues, etc. -- Physiological aspects, Health
Published
1995

195. Epidemiology and immunogenetic background of islet cell antibody-positive nondiabetic schoolchildren: Ulm-Frankfurt population study

Author

Boehm, Bernhard O., Manfras, Burkhard, Seissler, Jochen, Schoffling, Karl, Gluck, Michael, Holzberger, Gerhard, Seidl, Siegfried, Kuhnl, Peter, Trucco, Massimo, and Scherbaum, Werner A.

Subjects
Physiological aspects, Development and progression, Genetic aspects, Demographic aspects, Diabetes mellitus -- Demographic aspects -- Development and progression -- Genetic aspects, Type 1 diabetes -- Genetic aspects -- Development and progression, Islet cell stimulating antibodies -- Physiological aspects -- Genetic aspects, Diabetes -- Demographic aspects -- Development and progression -- Genetic aspects
Abstract

Islet cell antibodies (ICAs) were determined in a large cohort of white nondiabetic schoolchildren (n = 4287) from a homogenous population in southern Germany. The prevalance of ICA levels [is [...]

Published
1991

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