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The biconical radiation pattern extending from an active galactic nucleus (AGN) may strongly photoionize the circumnuclear interstellar medium (ISM) and stimulate emission from the narrow line region (NLR). Observations of the NLR may provide clues to the structure of dense material that preferentially obscures the bicone at certain angles, and may reveal the presence of processes in the ISM tied to AGN accretion and feedback. Ground-based integral field units (IFUs) may study these processes via well-understood forbidden diagnostic lines such as [O III] and [S II], but scales of $\sim10$s of pc remain challenging to spatially resolve at these wavelengths for all but the nearest AGN. We present recent narrow filter Hubble Space Telescope (HST) observations of diagnostic forbidden ([O III], [S II]) and Balmer (H$\alpha$, H$\beta$) lines in the NLR of IC 5063. This AGN's jet inclination into the plane of the galaxy provides an important laboratory for strong AGN-host interactions. We find evidence for a low-ionization loop which emits brightly in [S II] and [N II], and which may arise from plume-like hot outflows that ablate ISM from the galactic plane before escaping laterally. We also present spatially resolved Baldwin-Phillips-Terlevich diagnostic maps of the IC 5063 NLR. These maps suggest a sharp transition to lower-ionization states outside the jet path, and that such emission is dominated by $\sim10-40$ pc clumps and filamentary structure at large (>>25{\deg}) angles from the bicone axis. Such emission may arise from precursorless shocks when AGN outflows impact low-density hot plasma in the cross-cone., Comment: Accepted by ApJ. 18 pages, 8 figures. Follow-up paper to arXiv:2009.10153

OBJECTIVE: The human meniscus is essential in maintaining proper knee joint function. The meniscus absorbs shock, distributes loads, and stabilizes the knee joint to prevent the onset of osteoarthritis. The extent of its shock-absorbing role can be estimated by measuring the energy dissipated by the meniscus during cyclic mechanical loading. METHODS: Samples were prepared from the central and horn regions of medial and lateral human menisci from 8 donors (both knees for total of 16 samples). Cyclic compression tests at several compression strains and frequencies yielded the energy dissipated per tissue volume. A GEE regression model was used to investigate the effects of compression, meniscal side and region, and water content on energy dissipation in order to account for repeated measures within samples. RESULTS: Energy dissipation by the meniscus increased with compressive strain from ~0.1 kJ/m(3) (at 10% strain) to ~10 kJ/m(3) (at 20% strain) and decreased with loading frequency. Samples from the anterior region provided the largest energy dissipation when compared to central and posterior samples (p < 0.05). Water content for the 16 meniscal tissues was 77.9 (C.I. 72.0 – 83.8%) of the total tissue mass. A negative correlation was found between energy dissipation and water content (p < 0.05). CONCLUSION: The extent of energy dissipated by the meniscus is inversely related to loading frequency and meniscal water content.

Isolated, heterotopic gastric mucosa (HGM) can be a rare, pathologic leading point for intestinal intussusception in pediatric age. Affected children often experience recurrent episodes of intussusception, sometimes with delay in diagnosis and more than one surgery, because of difficulty in clear diagnosis and identification of HGM. Intraoperative findings of isolated HGM, as reported in literature, are visible or palpable lesions, protruding into the intestinal lumen. We describe the case of a 4 years old boy with recurrent intussusception, caused by a very small islet of ileal, isolated HGM, entirely developing in the submucosal layer and with a normal overlying mucosa. The difficulties in its diagnosis and treatment are described and the role of 99mTc pertechnetate scan and ultrasound are discussed. Keywords: Heterotopic gastric mucosa, Intussusception, 99mTc pertechnetate scan

Introduction Surgical navigation technology has recently become more prevalent for total knee arthroplasty. Surgical navigation typically requires pin placement in the proximal tibia diaphysis to stabilize the bone-tracking hardware, and there have been several recent reports of fractures through these residual navigation pin holes. The objective of this biomechanical study was to determine whether a difference exists in the torsional bone strength of a 5-mm navigation pin hole drilled at a single location in three different orientations: unicortical, bicortical, and transcortical. Methods Biomechanical composite sawbone tibias were used to test four conditions: the intact condition with no holes, a unicortical hole, a bicortical hole, and a transcortical hole through the proximal diaphysis. Seven specimens from each group were tested in external rotation to failure at 1 deg/sec. Torque-to-failure, absorbed energy-to-failure, and rotational angle-to-failure were statistically compared across the four groups. Results All specimens failed proximally by spiral oblique fractures. No statistical differences were found between unicortical and bicortical groups in torque-to-failure, energy-to-failure, and angle-to-failure. However, both unicortical and bicortical groups were markedly lower in all measures than the intact group. The transcortical group was markedly lower in all measures than the intact group and both unicortical and bicortical groups. Discussion An appropriately placed navigation residual pin hole, either unicortical or bicortical, markedly decreases the torque-to-failure, energy-to-failure, and angle-to-failure of the tibia compared with the intact condition in a synthetic sawbones model. No notable difference was detected between the unicortical and bicortical holes; however, an errant transcortical residual navigation pin hole markedly decreases all measures compared with an appropriately placed unicortical or bicortical hole.

Objectives Pleomorphic lung carcinoma (PLC) is a rare histotype of non-small cell lung cancer (NSCLC) characterized by aggressive clinical course, poor response to therapy and poor prognosis. Therefore, aim of our study is to analyze with 18F-FDG PET/CT a subset of patients affected by PLC to evaluate their metabolic characteristics in terms of SUVmax, MTV and TLG, in order to correlate them with overall survival (OS) and disease-free survival (DFS). Material and methods We retrospectively analyzed 49 consecutive patients with histologically defined PLC occurred to our Institution between 2003 and 2014. All patients underwent F18-FDG PET-CT before surgery and primary tumor was automatically segmented using an isocontour threshold method. SUV threshold for tumor segmentation was defined as the 41 % of lesion SUVmax. Total volume of the segmented VOI (MTV, centimeters cubed) and average SUV (SUVavg, grams per milliliter) in the segmented VOI were measured. Results In our population men were significantly more affected than women (42:7). According to Youden criteria, SUVmax, MTV41 and TLG41 best cut-off values to predict 2-year mortality were, 18.95, 27.89 and 290.45, respectively, with TLG41 showing best specificity (85 %) and positive predictive value (82.4 %). As concerning 2-year recurrence, SUVmax, MTV41 and TLG41 best cut-off values were 10.08, 27.89 and 134.85, with SUVmax showing best sensitivity (96.7 %) and negative predictive value (85.7 %). ROC curves confirmed that SUVmax, MTV41 and TLG41 were equally accurate to predict 2-year mortality and 2-year recurrence in our population. Conclusion Metabolic biomarkers such as SUVmax, MTV and TLG can be used as a prognostic index for disease progression, recurrence and death in patients with PLC, independently from other clinical/pathological prognostic elements.

We report the analysis of the deep (270 ks) X-ray Chandra data of one of the most radio-loud, Seyfert 2 galaxies in the nearby Universe (z=0.01135), IC 5063. The alignment of the radio structure with the galactic disk and ionized bi-cone, enables us to study the effects of both radio jet and nuclear irradiation on the interstellar medium (ISM). The nuclear and bi-cone spectra suggest a low photoionization phase mixed with a more ionized or thermal gas component, while the cross-cone spectrum is dominated by shocked and collisionally ionized gas emission. The clumpy morphology of the soft (3 keV) and the Fe K-alpha 6.4 keV emission are both extended to kpc size along the bi-cone direction, suggesting an interaction of nuclear photons with dense clouds in the galaxy disk, as observed in other Compton Thick (CT) active nuclei. The north-west cone spectrum also exhibits an Fe XXV emission line, which appears spatially extended and spatially correlated with the most intense radio hot-spot, suggesting jet-ISM interaction., 28 pages, 10 figures and 3 tables (with 10 more figures and 3 more tables in the Appendix), submitted to ApJ on May 24, 2021

Summary Objective To date, the pathophysiology of the meniscus has not been fully elucidated. Due to the tissue’s limited vascularization, nutrients and other molecular signals spread through the extracellular matrix via diffusion or convection (interstitial fluid flow). Understanding transport mechanisms is crucial to elucidating meniscal pathophysiology, and to designing treatments for repair and restoration of the tissue. Similar to other fibrocartilaginous structures, meniscal morphology and composition may affect its diffusive properties. The objective of this study was to investigate the role of solute size, and tissue structure and composition on molecular diffusion in meniscus tissue. Design Using a custom FRAP technique developed in our lab, we measured the direction-dependent diffusivity in human meniscus of six different molecular probes of size ranging from ∼300Da to 150,000Da. Diffusivity measurements were related to sample water content. SEM images were used to investigate collagen structure in relation to transport mechanisms. Results Diffusivity was anisotropic, being significantly faster in the direction parallel to collagen fibers when compared the orthogonal direction. This was likely due to the unique structural organization of the tissue presenting pores aligned with the fibers, as observed in SEM images. Diffusion coefficients decreased as the molecular size increased, following the Ogston model. No significant correlations were found among diffusion coefficients and water content of the tissue. Conclusions This study provides new knowledge on the mechanisms of molecular transport in meniscal tissue. The reported results can be leveraged to further investigate tissue pathophysiology and to design treatments for tissue restoration or replacement.

XDCPJ0044.0-2033 is one of the most massive galaxy cluster at z~1.6, for which a wealth of multi-wavelength photometric and spectroscopic data have been collected during the last years. I have reported on the properties of the galaxy members in the very central region (~70kpc x 70kpc) of the cluster, derived through deep HST photometry, SINFONI and KMOS IFU spectroscopy, together with Chandra X-ray, ALMA and JVLA radio data. In the core of the cluster, we have identified two groups of galaxies (Complex A and Complex B), seven of them confirmed to be cluster members, with signatures of ongoing merging. These galaxies show perturbed morphologies and, three of them show signs of AGN activity. In particular, two of them, located at the center of each complex, have been found to host luminous, obscured and highly accreting AGN (lambda=0.4-0.6) exhibiting broad Halpha line. Moreover, a third optically obscured type-2 AGN, has been discovered through BPT diagram in Complex A. The AGN at the center of Complex B is detected in X-ray while the other two, and their companions, are spatially related to radio emission. The three AGN provide one of the closest AGN triple at z>1 revealed so far with a minimum (maximum) projected distance of 10 kpc (40 kpc). The discovery of multiple AGN activity in a highly star-forming region associated to the crowded core of a galaxy cluster at z~1.6, suggests that these processes have a key role in shaping the nascent Brightest Cluster Galaxy, observed at the center of local clusters. According to our data, all galaxies in the core of XDCPJ0044.0-2033 could form a BCG of Mstar ~ 10^{12} Msun hosting a BH of 2 x 10^{8}-10^{9}Msun, in a time scale of the order of 2.5 Gyrs., Proceeding for the IAUS 356: Nuclear Activity in Galaxies Across Cosmic Time. arXiv admin note: text overlap with arXiv:2008.11132

With the prospective of developing an integrated monitoring system aimed at assessing whether a landing gear has experienced hard impact during the approach, a dedicated method is developed aimed at determining vertical speed by means of strain measurement via FBG strain sensors. Representative impacts on simple structural elements have been reproduced in laboratory, as aluminum slender beams of different lengths were dropped from given heights onto a steel plate base. Contact velocities have been estimated by deformations detection.

We present spatially resolved BPT mapping of the extended narrow line regions (ENLRs) of seven nearby Seyfert 2 galaxies, using HST narrow band filter imaging. We construct the BPT diagrams using $\leq$ 0.1" resolution emission line images of [O III]$\lambda$5007, H$\alpha$, [S II]$\lambda$$\lambda$6717,6731, and H$\beta$. By mapping these diagnostic lines according to the BPT classification, we dissect the ENLR into Seyfert, LINER, and star-forming regions. The nucleus and ionization cones are dominated by Seyfert-type emission, which can be interpreted as predominantly photoionization by the active galactic nucleus (AGN). The Seyfert nucleus and ionization cones transition to and are surrounded by a LINER cocoon, extending up to $\sim$ 250 pc in thickness. The ubiquity of the LINER cocoon in Seyfert 2 galaxies suggests that the circumnuclear regions are not necessarily Seyfert-type, and LINER activity plays an important role in Seyfert 2 galaxies. We demonstrate that spatially resolved diagnostics are crucial to understanding the excitation mechanisms in different regions and the AGN-host galaxy interactions., Comment: 19 pages, 14 figures; accepted for publication in ApJ

Manual material handling (MMH) contributes to a large percentage of musculoskeletal disorders. One of its fundamental activities is load carrying that can be accomplished in several strategies, with each one imposing different types of stresses on the musculoskeletal system. Therefore, the first goal of this study was to determine the effect of different carrying methods on walking stability using motion capture analysis. Second, to analyze gait adaptations to stresses associated with load carrying in order to prevent falling. Third, to investigate the effect of these stresses coupled with human body adjustment on the forces at the L5/S1 disc. Thirty participants carried 10 and 30 lbs loads via frontal, lateral, bilateral, and posterior carriages. Frontal and lateral methods generated the most unstable conditions compared to the others. The unstable locomotion forced the gait parameters to be significantly altered in order to maintain stability. Additionally, the postures maintained in these conditions resulted in significantly high compression and shear forces acting at the L5/S1 disc when compared to the other carrying methods. Moreover, heavier weights exacerbated the effect on the dependent variables. Notably, bilateral and posterior carrying methods provided results comparable to the unloaded walking baseline. In conclusion, to reduce the potential risks associated with load carrying, the recommendation to split the load between both hands using bilateral carrying method or carrying it posteriorly should be taken into account while designing MMH activities.

We present ALMA 230 GHz continuum and CO(2-1) observations of the nearby Compton-thick Seyfert galaxy ESO428-G14, with angular resolution 0.'' 7 (78 pc). CO(2-1) is distributed in clumpy spiral arms, a lopsided circumnuclear ring (CNR) with similar to 200 pc radius, and a transverse gas lane with size