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154. Regulation of IgE and IgG4 synthesis in patents with hyper IgE syndrome.

Author

Ishizaka, A., Joh, K., Shibata, R., Wagatsuma, Y., Nakanishi, M., Tomizawa, K., Kojima, K., Kandil, E., Sakiyama, Y., and Matsumoto, S.

Subjects
IMMUNOREGULATION, IMMUNOGLOBULIN G, IMMUNOGLOBULIN E, BLOOD plasma, ANTINEOPLASTIC agents, CYTOKINES, CELLULAR immunity
Abstract

In order to investigate the imbalance of IgG subclasses and its relationship to IgE level, 14 patients with hyper IgB syndrome (HIE syndrome) were examined for serum IgG subclasses and IgE levels and five of these patients were studied for in vitro IgB and IgG subclass production by peripheral blood lymphocytes (PBL) in response to interleukin-4 (IL-4)/interferon-gamma (IFN-γ). Serum IgB levels were highly correlative with serum IgG4 levels (r = 0.75, P < 0.005), but not with IgG1, IgG2 or IgG3 levels (r = 0.21, 0.43 and 0.41, respectively). In an in vitro study, recombinant IL-4 enhanced not only spontaneous IgE synthesis but also lgG4 synthesis in cultures of PBL from patients with HIE syndrome as well as in healthy donors (P < 0.01), and the effect of recombinant IL-4 on both IgB and IgG4 synthesis was inhibited by low concentrations of recombinant IFN-γ (P < 0.01). The disturbed regulation of IgB and IgG4 seen in patients with hyper IgB syndrome may be caused mainly by the disturbed regulation of both cytokines. [ABSTRACT FROM AUTHOR]

Published
1990

163. PHENIX: Preliminary conceptual design report

Author

Gregory, J. C., Shiina, T., Takahashi, Y., Tocci, M., Gupta, S. K., Aronson, S. H., Fatyga, M., Gavin, S., Guryn, W., Harder, J., Kahn, S., Kistenev, E., Kroon, P., Murtagh, M. J., O Brien, E., Paffrath, L., Rankowitz, S., Rescia, S., Shea, T. K., Tanaka, M., Michael Tannenbaum, Woody, C. L., Beery, P., Fung, S. Y., Kang, J. H., Seto, R., Bai, Xi-Xiang, Jing, Ke-Xing, Liu, Xiao-Ping, Liu, Zu-Hua, Mao, Ya-Jun, Sa, Ben-Hao, Sun, Zu-Xun, Wan, Yu-De, Wang, Zhong-Qi, Xu, Jin-Cheng, Zhang, Xiao-Ze, Zheng, Yu-Ming, Zhou, Shu-Hua, Chi, C. Y., Cole, B., Dodd, J., Li, Q. M., Nagamiya, S., Nayak, T., Sippach, W., Stankus, P., Vossnack, O., Wang, F. Q., Wang, Y. F., Wu, Y. D., Yang, X. H., Zajc, W. A., Zhan, W. L., Dennis, L. C., Frawley, Anthony D., Liu, X. T., Petitt, G., Zhan, Z., Iwata, H., Sakaguchi, A., Sugitate, T., Sumi, Y., Aryaeinejad, R., Devries, R., Cole, J., Drigert, M., Cheng, Zheng-Dong, Chen, Shao-Min, Li, Qi-Ming, Lu, Jun-Guang, Wang, De-Wu, Zhao, Wei-Qin, Zheng, Zhi-Peng, Zhu, Yu-Can, Ammosov, V. V., Denisov, A., Durum, A., Gapienko, V., Galitsky, Yu, Gutnikov, Yu, Ivanilov, A., Kochetkov, V. I., Korablev, B., Kozelov, A., Makeev, V. V., Melnikov, E., Mikhailov, Yu, Onuchin, V., Pishchalnikov, Yu, Protopopov, Yu, Rykalin, V. I., Shestermanov, K., Starkov, A., Strustyumov, D., Surkov, A., Zaets, V., Zaichenkov, A., He, Rui-Rong, Jin, Gen-Ming, Luo, Yi-Xiao, Wei, Bao-Wan, Xi, Hong-Fei, Ye, Feng, Zhan, Wen-Long, Zhang, Jing-Yu, Akiba, Y., Hamagaki, H., Homma, S., Sako, H., Sekimoto, M., Ewell, L. A., Hill, J. C., Skank, H., Thomas, W., Wohn, F. K., Anatori, L., Baldin, A., Malakhov, A., Pavel, Z., Sergei, A., Sergei, R., Vladimir, D., Yuri, A., Chiba, J., Mori, Y., Nomachi, M., Sasaki, Osamu, Sakamoto, H., Shintomi, T., Tanaka, K. H., Sim, K. S., Belyaev, S., Fokin, S., Ippolitov, M., Karadev, K., Lebedev, A., Manko, V., Nyanine, A., Vinogradov, A., Enyo, H., Kaneko, H., Costales, J., Konig, Z., Hansen, L., Namboordiri, N., Sangster, C., Thomas, J., Tonse, S., Yamamoto, R., Zasadzinski, R., Boissevain, J. G., Carey, T. A., Gavron, A., Hecke, H., Jacak, B., Kapustinsky, J., Leitch, M., Lillberg, J., Mcgaughey, P. L., Moss, J., Simon-Gillo, J., Sondheim, W. E., Sullivan, J. P., Waters, L., Kirk, P. N., Wang, Z. F., Yu, J. C., Zganjar, E. F., Garpman, S., Gustafsson, H. A., Oskarsson, A., Otterlund, I., Soderstrom, K., Stenlund, E., Barrette, J., Mark, S. K., Nikkinen, L., Normand, L., Rosati, M., Berger, F., Glasow, R., Kampert, K. H., Peitzmann, T., Santo, R., Takada, E., Braun-Munzinger, P., David, G., Hemmick, T., Hong, B., Llope, W. J., Panitkin, S., Rao, M., Stachel, J., Xu, N., Zhang, Y., Zou, C., Awes, T., Kim, Hee, Obenshain, F., Plasil, F., Saini, S., Young, G. R., Bao, Shang-Lian, Chen, Jia-Ehr, Jiang, Dong-Xing, Wei, Lun-Cun, Abrosimov, N. K., Chernov, N. N., Ivochkin, V. G., Kochenda, L. M., Ryabov, G. A., Shchegelsky, V., Seliverstov, D. M., Smirnoff, N., Spiridenkov, E. M., Vorobov, A., Dietzsch, O., Cansian Silva, N., Takagui, E. M., Carlin, N., Matheus, R., Szanto Toledo, A., Kim, J. C., He, X. C., Kreke, J., Sorensen, S., Torshizi, G., Hayano, R., Ishikawa, T., Sakurai, H., Shigaki, K., Tamura, H., Arai, I., Igarashi, Y., Ikeda, T., Ise, M., Kato, S., Kitayama, H., Kumagai, A., Kurita, K., Miake, Y., Nagasaka, Y., Tobinai, H., Tomizawa, K., Ueno, S., Waki, K., Yagi, K., Yamashita, Y., Cornell, E., Maguire, C., Ramayya, A. K., Barris, J., Bennett, M., Chikanian, A., Diebold, G., Shiva Kumar, B., Mitchell, J., Nagle, J., Oulette, A., Pope, K., Borenstein, S., Kehoe, W. L., and Kimura, K.

164. A comparison of numerical solutions of the Boltzmann Transport Equation for high energy electron transport silicon

Author

Antonio ABRAMO, Baudry, L., Brunetti, R., Castagné, R., Charef, M., Dessenne, F., Dolfus, P., Dutton, R., Engl, W. L., Fauquembergue, R., Fiegna, C., Fischetti, M. V., Galdin, S., Goldsman, N., Hackel, M., Hamaguchi, C., Hess, K., Hennacy, K., Hesto, P., Higman, J. M., Iizuka, T., Jungemann, C., Kamakura, Y., Kosina, H., Kunikiyo, T., Laux, S., Lin, H., Maziar, C., Mizuno, H., Peifer, H. J., Ramaswamy, S., Sano, N., Scrobohaci, P. G., Selberherr, S., Takenaka, M., Tang, T. W., Taniguchi, K., Thobel, J. L., Thoma, R., Tomizawa, K., Tomizawa, M., Vogelsang, T., Wang, S. L., Wang, X., Yao, C. S., Yoder, P. D., and Yoshii, A.

165. Regulation of IgE and IgG4 synthesis in patients with hyper IgE syndrome

Author

Ishizaka, A., Joh, K., Shibata, R., Wagatsuma, Y., Nakanishi, M., Tomizawa, K., Kojima, K., Eman Kandil, Sakiyama, Y., and Matsumoto, S.

Subjects
Adult, Adolescent, Infant, Dermatitis, Syndrome, Immunoglobulin E, Staphylococcal Infections, Recombinant Proteins, Interferon-gamma, Child, Preschool, Hypergammaglobulinemia, Immunoglobulin G, Humans, Interleukin-4, Lymphocytes, Child, Cells, Cultured, Research Article
Abstract

In order to investigate the imbalance of IgG subclasses and its relationship to IgE level, 14 patients with hyper IgE syndrome (HIE syndrome) were examined for serum IgG subclasses and IgE levels and five of these patients were studied for in vitro IgE and IgG subclass production by peripheral blood lymphocytes (PBL) in response to interleukin-4 (IL-4)/interferon-gamma (IFN-gamma). Serum IgE levels were highly correlative with serum IgG4 levels (r = 0.75, P less than 0.005), but not with IgG1, IgG2 or IgG3 levels (r = 0.21, 0.43 and 0.41, respectively). In an in vitro study, recombinant IL-4 enhanced not only spontaneous IgE synthesis but also IgG4 synthesis in cultures of PBL from patients with HIE syndrome as well as in healthy donors (P less than 0.01), and the effect of recombinant IL-4 on both IgE and IgG4 synthesis was inhibited by low concentrations of recombinant IFN-gamma (P less than 0.01). The disturbed regulation of IgE and IgG4 seen in patients with hyper IgE syndrome may be caused mainly by the disturbed regulation of both cytokines.

166. A letter from K. Tomizawa to Frank Mohler about Tadakatsu Miyazaki, April 11, 1924

Author

Tomizawa, K. and Tomizawa, K.

Abstract

A letter written by K. Tomizawa of the Sutter Street Branch of the San Francisco YMCA to Mr. Frank Mohler of the International YMCA College (now Springfield College) in regards to Tadakatsu Miyazaki's attendance at the College., Mr. Miyazaki, originally from Japan, was born in 1897. Mr. Miyazaki applied to the International YMCA College in 1924, and graduated with a B.S. from the Boys Work Division in 1928. He also did volunteer work for the YMCA in San Francisco before applying to the College. After graduating from the College, Mr. Miyazaki accepted a position as Boys Work Secretary at the YMCA in Osaka, Japan. He also was in charge of the Personnel Department School Division, and as Director of Club among Boys.

169. A small-sized MWPC with 1 mm wire spacing as a beam/target chamber for nuclear experiments

Author

Ninomiya, M., primary, Arai, I., additional, Manabe, A., additional, Nunokawa, H., additional, Tanaka, M., additional, Tomizawa, K., additional, Yagi, K., additional, Kobayashi, T., additional, Chiba, J., additional, Nakai, K., additional, Sano, H., additional, Sasaki, S., additional, Nagae, T., additional, Tokushuku, K., additional, and Sekimoto, M., additional

Published
1988
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