291 results on '"Tintoré, P."'
Search Results
152. Gadolinium-enhanced brain lesions in multiple sclerosis relapse
- Author
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Martín-Aguilar, L., Presas-Rodriguez, S., Rovira, À., Capellades, J., Massuet-Vilamajó, A., Ramió-Torrentà, L., Tintoré, M., Brieva-Ruiz, L., Moral, E., Cano-Orgaz, A., Blanco, Y., Batlle-Nadal, J., Carmona, O., Gea, M., Hervás-García, J.V., and Ramo-Tello, C.
- Abstract
To study the clinico-radiological paradox in multiple sclerosis (MS) relapse by analyzing the number and location of gadolinium-enhanced (Gd+) lesions on brain MRI before methylprednisolone (MP) treatment.
- Published
- 2022
- Full Text
- View/download PDF
153. A proposed ecosystem-based management system for marine waters: linking the theory of environmental policy to the practice of environmental management
- Author
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Rafael Sardà, Tim O'Higgins, Roland Cormier, Amy Diedrich, and Joaquin Tintoré
- Subjects
ecosystem approach ,ecosystem-based management ,ecosystem goods and services ,environmental management ,marine environment ,marine ecosystems ,marine management strategy ,oceans policy ,Biology (General) ,QH301-705.5 ,Ecology ,QH540-549.5 - Abstract
New coastal and marine management strategies have recently been developed in many countries and regions. From an ecosystem approach perspective, the aim of such strategies is the maintenance of ecosystem integrity while enabling the sustainable use of ecosystem goods and services. There is, however, a need for harmonized definitions and standardized processes to deal not only with the interjurisdictional and multidisciplinary complexities that are associated with such strategies but also with the extensive timelines and resources implicated in the planning and implementation of these strategies. The ecosystem-based management system proposed here is based on three pillars that facilitate the integration of an ecosystem approach to coastal and oceans policy development, regardless of the ecosystem or administrative scales. The managerial pillar is based on classical risk-management systems that incorporate environmental considerations and objectives within a continuous improvement cycle of adaptive management. The managerial pillar is supported by governance structures that provide oversight and thereby ensure that planning and implementation activities adhere to modern environmental principles. The information pillar ensures that data and scientific advice are based on current knowledge, and the participation pillar brings together communication and consultation requirements as indicated by the principles of the ecosystem approach.
- Published
- 2014
- Full Text
- View/download PDF
154. Corrigendum to 'Observations of a phytoplankton spring bloom onset triggered by a density front in NW Mediterranean' published in Ocean Sci., 10, 657–666, 2014
- Author
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A. Olita, S. Sparnocchia, S. Cusí, L. Fazioli, R. Sorgente, J. Tintoré, and A. Ribotti
- Subjects
Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 - Abstract
No abstract available.
- Published
- 2014
- Full Text
- View/download PDF
155. Primary Central Nervous System Vasculitis Following Alemtuzumab Treatment for Multiple Sclerosis
- Author
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Varela, Lucía, Pappolla, Agustín, Heriz, Alejandra, Márquez, Rocío, Vega, Otto, Christiansen, Silvia, Rugiero, Marcelo, Midaglia, Luciana, Salerno, Annalaura, Tintoré, Mar, and Rovira, Àlex
- Published
- 2023
- Full Text
- View/download PDF
156. Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain: Abstracts of Symposia and free communications
- Author
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Harms, L., Bock, A., JÄnisch, W., Valdueza, J., Weber, J., Link, I., De Keyser, J., Goossens, A., Wilczak, N., Vedeler, C., Bjorge, L., Uvestad, E., Conti, G., Williams, K., Ginsberg, L., Rafique, S., Rapoport, S. I., Gershfeld, N. L., De La Meilleure, G., Crevits, L., Faiss, J. H., Heye, N., Blanke, J., Sackmann, A., Kastrup, O., Doornbos, R., van der Worp, H. B., Kappelle, L. J., Bar, P. R., Davie, C. A., Barker, G. J., Brenton, D., Miller, D. H., Thompson, A. J., Block, F., Schwarz, M., Delodovici, L., Baruzzi, F., Bonaldi, G., Dario, A., Marra, A., Mercuri, A., Dworzak, F., Cavallari, P., Confalonieri, P., Zuffi, M., Antozzi, C., Cornelio, F., Baldissera, F., Chassande, B., Ameri, A., Eymard, B., Poisson, M., Vérier, A., Brunet, P., Congia, S., Murgia, P. L., Cannas, A., Borghero, G., Uselli, S., Mellino, G., Ferrai, R., Lampis, R., Massa, R., Muzzetto, B., Giannini, F., Rossi, S., Cioni, R., d'Aniello, C., Guarneri, A., Battistini, N., Ceriani, F., Del Santo, A., Poloni, M., Campo, J. F., Iglesias, F., Guitera, M. V., Farinas, C., Pascual, J., Leno, C., Berciano, J., Thorpe, I. W., Kendall, B. E., McDonald, W. I., Moulignier, A., Dromer, F., Baudrimont, M., Dupont, B., Gozlan, J., El Amrani, M., Petit, J. C., Roullet, E., Sterzi, R., Causaran, R., Protti, A., Riva, M., Erminio, F., Arena, O., Villa, F., Maccagnano, E., Miletta, M., Spinelli, F., Ben-Hur, T., Weidenfeldl, J., Rao, N. S., Chari, C. C., Laforet, P., Matheron, S., Adams, D., Chemouilli, Ph., Desi, M., Said, G., Davous, P., Lionnet, F., Pulik, M., Genet, P., Rozenberg, F., Cartier, L. M., Castillo, J. L., Cea, J. G., Villagra, R., de Saint Martin, L., Mahieux, F., Manifacier, M. J., Mattos, K., Queiros, C., Publio, L., Vinhas, V., PeÇanha-Martins, A. C., Melo, A., Liska, U., Zifko, U., Budka, H., Drlicek, M., Grisold, W., Kaufmann, R., Kaiser, R., Czygan, M., Gomes, I., Jones, N., Cunha, S., EmbiruÇu, E. Katiane, Vieira, V., Araujo, I., Alexandra, M., Ferreira, A., Goes, J., Chemouilli, P., Israel-Biet, Masson, H., Lacroix, C., Gasnault, J., Hildebrandt-Müller, B., Oschmann, P., Krack, P., Willems, W. R., Dorndorf, W., Freitas, V., Bittencourt, A., Fernandes, D., Nascimento, M. H., Severo, M., Moraes, D., Muller, M., Hasert, K., Merkelbach, S., Schimrigk, K., van Oosten, B. W., Lai, M., Polman, C. H., Bertelsmann, F. W., Hodgkinson, S., Cabre, P. H., Volpe, L., Smadja, D., Vernant, J. P., Villaroya, H., Violleau, K., Younes-Chennoufi, A. Ben, Baumann, N., Villanueva-Hemandez, P., Ballabriga, J., Basart, E., Arbizu, T. X., Perez-Serra, J., Vinuels, F., Giron, J. M., Castilla, J. M., Redondo, L., Izquierdo, G., Lauer, K., Henneberg, A., Bittmann, N., Link, D., Wollinsky, K. H., Mobner, R., Fassbender, K., Kuhnen, J., Schwartz, A., Hennerici, M., Miller, A., Lider, O., Abramsky, O., Weiner, H. L., Offner, H., Vanderbark, A. A., Paoino, E., Fainardi, E., Addonizio, M. C., Ruppi, P., Tola, M. R., Granieri, E., Carreras, M., Sazdovitch, V., Joutel, A., Verdier-taillefer, M. H., Heinzlef, O., Radder, C., Tournier-Lasserve, E., Brenner, R. E., Munro, P. M. G., Williams, S. C. R., Bell, J. D., Hawkins, C. P., Filippi, M., Campi, A., Dousset, V., Canal, N., Comi, G., Zhu, J., Weber, F., Retska, R., List, J., Zhang, L., Brock, M., Taphoorn, M. J. B., Heimans, J. J., van der Veen, E. A., Karim, A. B. M. F., Sarazin, M., Argentino, N., Delattre, J. Y., Derkinderen, P., Buchwald, B., Schroter, G., Serve, G., Franke, C. H., Conrad, B., Kitchen, N. D., Thomas, D. G. T., Forman, A. D., Ang, Kie- Kian, Price, R., Stephens, C., Salmaggi, A., Nermni, R., Silvani, A., Forno, M. G., Luksch, R., Boiardi, A., Grzelec, H., Fryze, C., Nowacki, P., Zdziarska, B., Sanson, M., Merel, P., Richard, S., Rouleau, G., Thomas, G., Olsen, N. K., Pfeiffer, P., Egund, N., Bentzen, S. M., Johannesen, L., Mondrup, K., Rose, C., Zyluk, B., Wondrusch, E., Berger, O., Fast, N., Jellinger, K., Lindner, K., Urman, A., Thibault, J. L., Duyckaerts, Ch., Strik, H., Muller, B., Richter, E., Krauseneck, P., Steinbrecher, A., Schabet, M., Hess, C., Bamberg, M., Dichgans, J., Counsell, C. E., McLeod, M., Grant, R., Creel, G. B., Claus, D., Sieber, E., Engelhardt, A., Rechlin, T., Thierauf, P., Neubauer, U., Peresson, M., Di Giovacchino, G., Romani, G. L., Di Silverio, F., Danek, A., Kuffner, M., Hoermann, R., Schopohl, J., Laska, M., Heye, B., Zangaladze, A. T., Valls-SoIè, J., Cammarota, A., Alvarez, R., Tolosa, E., Hallett, M., Ulbricht, D., Ganslandt, O., Kober, H., Vieth, J., Grummich, P., Pongratz, H., Brigel, C., Fahlbusch, R., Serra, F. P., Palma, V., Nolfe, G., Buscaino, G. A., Rothstein, T. L., Gibson J. M., Morrison P. M., Collins A. D., Eiselt, M., Wagnur, H., Zwiener, U., Schindler, T., Efendi, H., Ertekin, C., Erfas, M., Larsson, L. E., Sirin, H., AraÇ, N., Toygar, A., Demir, Y., Seddigh, S., Vogt, T. H., Hundemer, H., Visbeck, A., Pastena, L., Faralli, F., Mainardi, G., Gagliardi, R., Linden, D., Berlit, P., Lopez, O. L., Becker, J. T., Jungreis, C., Brenner, R., Rezek, D., Dekesky, S. T., Estol, C., Boller, F., Fernandez, J. M., Mederer, S., Batlle, J., Turon, A., Codina, A., Hitzenberger, P., Vila, N., Valls-SolÇ, J., Chamorro, A., Pouget, J., Schmied, A., Morin, D., Azulay, J. Ph., Vedel, J. P., Montalt, J., Escudero, J., Barona, R., Campos, A., Varli, K., Ertem, E., Uludag, B., Yagiz, A., Privorkin, Z., Steinvil, Y., Kott, E., Combarros, O., Sanchez-Pernaute, R., Orizaola, P., Mokrusch, Th., Kutluaye, E., Selcuki, D., Ertikin, C., Zettl, U., Gold, R., Harvey, G. K., Hartung, H. P., Toyka, K. V., Wokke, J. H. J., Oey, P. L., Ippel, P. F., Jansen, G. H., Franssen, H., Toyooka, K., Fujimura, H., Ueno, S., Yoshikawa, H., Yorifuji, S., Yanagihara, T., Talamon, C., Tzourio, C., Kiefer, R., Jung, S., Toyka, K., Ruolt, I., Tranchant, C., Mohr, M., Warter, J. M., Younger, D. S., Rosoklija, G., Hays, A. P., Kurita, R., Hasegawa, O., Matsumto, M., Komiyama, A., Nara, Y., Oueslati, S., Belal, S., Turki, I., Ben Hamida, C., Hentati, F., Ben Hamida, M., Kwiecinski, H., Krolicki, L., Domzal-Stryga, A., Dellemijn, P. L. I., van Deventer, P., van Moll, B., Drogendijk, T., Vecht, Ch. J., Nemni S., Amadio, Fazio, R., Galardin, G., Delodovici, M. L., Peghi, E., Monticelli, M. L., Sessa, A., Viguera, M. L., Palomar, M., Gamez, J., Cervera, C., Navarro, C., Serena, J., Duran, I., Fernandez, A. L., Comabella, M., Nos, C., Rio, J., Montalban, J., Navarro, X., Verdu, E., Darbra, S., Buti, M., Mrabet, A., Fredj, M., Gouider, R., Tounsi, H., Khalfallah, N., Haddad, A., Dbaiss, T., Ghnassia, R., Rouillet, E., Chedru, F., Porsche, H., Strenge, H., Li, S. W., Young, Y. P., Garcia, A. A., Baron, P., Scarpini, E., Bianchi, R., Conti, A., Livraghi, S., Rees, J. H., Gregson, N. A., Hughes, R. A. C., Sedano, M. J., Calleja, J., Canga, E., Bahou, Y., Biary, N., Al Deeb, S. M., Guern, E. L. E., Gugenheim, M., Tardieu, S., Aisonobe, T. M., Agid, Y., Bouche, P., Brice, A., Rautenstrauss, B., Nelis, E., Grehl, H., Van Broeckhoven, C., Pfeiffer, R. A., Liehr, T., Ganzmann, E., Gehring, C., Neundörfer, B., Geremia, L., Doronzo, R., Sacilotto, G., Sergi, P., Pastorino, G. C., Scarlato, G., Planté-Bordeneuve, V., Mantel, A., Baas, F., Moser, H., Antonini, A., Psylla, M., Günther, I., Vontobell, P., Beer, H. F., Leenders, K. L., Chaudhuri, K. Ray, Parker, J., Pye, I. F., Millac, P. A. H., Abbott, R. J., Sutter, M., Albani, C., de Rijk, M. C., Breteler, M. M. B., Graveland, G. A., van der Mechè, F. G. A., Hofman, A., Keipes, M., Hilger, Ch., Diederich, N., Metz, H., Hentges, F., Pollak, P., Benabid, A. L., Limousin, P., Hoffmann, D., Benazzouz, A., Perret, J., Laihinen, A., Rinne, J. O., Ruottinen, H., Nagren, K., Lehikoinen, P., Oikonen, V., Ruotsalainen, U., Rinne, U. K., Cocozza, S., Pizzuti, A., Cavalcanti, F., Monticelli, A., Pianese, L., Redolfi, E., Paiau, F., Di Donato, S., Pandolfo, M., Palau, F., Monros, E., De Michele, G., Smeyers, P., Lopez-ArLandis, J., Uilchez, J., Filla, A., Genis, D., Matilla, T., Volpini, V., Blanchs, M. I., Davalos, A., Molins, A., Rosell, J., Estivill, X., De Jonghe, P., Smeyers, G., Krols, L., Mercelis, R., Hazan, J., Weissenbach, J., Martin, J. J., Warner, T. A. T., Williams, L., Orb, A. S., Harding, A. E., Giunti, P., Sweeney, M. G., Spadaro, M., Jodice, C., Novelletto, A., Malaspina, P., Frontali, M., Salmon, E., Gregoire, Del Fiore, Comar, Franck, G., Scheltens, P. H., Siegfried, K., Dartigues, E., De Deyn, P., Horn, R., Nelson, I., Hanna, M. G., Morgan-Hughes, J. A., Collinge, J., Palmer, M. S., Campbell, T., Mahal, S., Sidle, K., Humphreys, C., Tavitian, B., Pappata, S., Jobert, A., Crouzel, A. M., DiGiamberardino, L., Steimetz, G., Barbanti, P., Fabbrini, G., Salvatore, M., Buzzi, M. G., Di Piero, V., Petraroli, R., Sbriccoli, A., Pocchiari, M., Macchi, G., Lenzi, G. L., Spiegel, R., Maguire, P., Schmid, W., Ott, A., Bots, M. L., Grobbe, D. E., Hofman, A., Howard, R. S., Russell, S., Losseff, N., Hirsch, N. P., Couderc, R., Bailleul, S., Nargeot, M. C., Touchon, J., Picot, M. C., Rizzo, M., Watson, G., McGehee, D., Dingus, T., Kappos, L., Radü, E. W., Haas, J., Hartard, C. H., Spuler, S., Yousry, T., Voltz, R., Scheller, A., Holler, E., Hohlfeld, R., Scolding, N. J., Sussman, J., Kolar, O. J., Farlow, M. R., Rice, P. H., Zipp, F., Sotgiu, S., Weiss, E. H., Wekerle, H., Chalmers, R., Robertson, N., Compston, D. A. S., Martino, G., Clementi, E., Brambilla, E., Moiola, L., Martinelli, V., Colombo, B., Poggi, A., Rovaris, M., Grimaldi, L. M. E., Roth, M. P., Descoins, P., Ballivet, S., Ruidavets, J. B., Waubant, E., Nogueira, L., Cambon-Thomsen, A., Clanet, M., Leppert, D., Hauser, S., Lugaresi, A., Tartaro, A., D'aurelio, P., Befalo, L. L. O., Thomas, A., Malatesta, G., Gambi, D., Benedikz, J. E. G., Magnusson, H., Poser, C. M., Guomundsson, G., Bates, T. E., Davies, S. E. C., Clark, J. B., Landon, D. N., ùther, J. R., Rautenberg, W., Overgaard, K., Sereghy, T., Pedersen, H., Boysen, G., Diez-Tejedor, E., Carceller, F., Gutierrez, M., Lopez-Pajares, R., Roda, J. M., Chandra, B., Ricart, W., Gonzalez-Huix, F., Molina, A., Rundek, T., Demarin, V., De Reuck, J., Boon, P., Decoq, D., Strijckmans, K., Goethals, P., Lemahieu, I., Nibbio, A., Chabriat, H., Vahedi, K., Nagy, T., Verin, M., Mas, J. L., Julien, J., Ducrocq, X., Iba-Zizen, M. T., Cabanis, E. A., Bousser, M. G., Rolland, Y., Landgraf, F., Bompais, B., Lemaitre, M. H., Edan, G., Vorstrup, S., Knudsen, L., Olsen, K. Skovgaard, Videbaek, C., Schroeder, T., van Gijn, J., Jansen, H. M. L., Pruim, J., Paans, A. M. J., Willemsen, A. T. M., Hew, J. M., vd Vliet, A. M., Haaxma, R., Vaalburg, W., Minderhoud, J. M., Korf, J., Soudain, S. E., Ho, T. W., Mishu, B., Li, C. Y., Nachainkin, I., Gao, C. Y., Cornblath, D. R., Griffin, J. W., Asbury, A. K., Blaser, M. J., McKhann, G. M., Ho, T., Macko, C., Xue, P., Stadlan, E. M., Ramos-Alvarez, M., Valenciano, L., Visser, L. H., van der Meché, F. G. A., van Darn, P. A., Meulstee, J., Schmitz, P. I. M., Jacobs, B., Oomes, P. G., Kleyweg, R. P., Jacobs, B. C., Endtz, H. P., van Doorn, P. A., van der Mech, F. G. A., Van den Berg, L. H., Mollee, I., Logtenberg, T., Thomas, P. K., Plant, G., Baxter, P. J., Luis, R. Santiago, Matsumoto, M., Notermans, N. C., Wokke, J. H. J., Lokhorst, H. M., van der Graaf, Y., Jennekens, F. G. I., Azulay, J. P., Bille-Turg, F., Valentin, P., Farnarier, G. G., Pellissier, J. F., Serratrice, G., Quasthoff, S., Schneider, U., Grafe, P., Hilkens, P. H. E., Moll, J. W. B., van der Burg, M. E. L., Planting, A. S. T., van Putten, W. L. J., van den Bent, M. J., Birklein, F., Spitzer, A., Lang, E., Neundorfer, B., Diehl, R. R., Lücke, D., Smith, G. D. P., Mathias, C. J., Serra, J., Campera, M., Ochoa, J. L., Ray Chaudhuri, K., Pavitt, D., Alam, M., Handwerker, H. O., Bleasdale-Barr, K., Smith, G., Murray, N. M. F., Hawkins, P., Pepys, M., Gellera, C., DiDonato, S., Taroni, F., Uncini, A., Di Muzio, A., Servidei, S., Silvestri, G., Lodi, R., Iotti, S., Barbiroli, B., Morrissey, S. P., Borruat, F. X., Francis, D., Mosely, I., Hansen, H. C., Helmke, K., Kunze, K., Sadzot, B., Maquet, P., Lemaire, Plenevaux, Damhaut, Sommer, C., Myers, R. R., Berta, E., Mantegazza, R., Argov, Z., Shapira, Y., Wirguin, I., Beuuer, J., Franke, C., Roberts, M., Willison, H., Vincent, A., Newsom-Davis, J., Morrison, K. E., Damels, R., Francis, M., Campbell, L., Davies, K. E., Kohler, W., Bucka, C., Hertel, G., Kanovsky, P., Auer, D., Ackermann, H., Klose, U., Naegele, Th., Bien, S., Voigt, K., Fink, G. R., Stephan, K. M., Wise, R. J. S., Mullatti, N., Hewer, L., Frackowiak, R. S. J., Weiller, C. S., Rijnites, M., Jueptner, M., Bauermann, T., Krams, M., Diener, H. C., van Walderveen, M. A. A., Barkhof, F., Hommes, O. R., Valk, J., Willmer, J. P., Guzman, D. A., Passingham, R. E., Silbersweig, D., Ceballos-Baumann, A., Frith, C. D., Frackowiak, R., Lucas, C. H., Goullard, L., Marchau, M. J., Godefroy, O., Rondepierre, P. H., Chamas, E., Mounier-Vehier, F., Leys, D., Renato, J., Verdugo, M. S. C., Campero, M., Jose, L., Ochoa, D. S. C., Vivancos, F., Tejedor, E. Diez, Martinez, N., Roda, J., Frank, A., Barreiro, P., Satoh, Y., Nagata, K., Maeda, T., Hirata, Y., YalÇinerner, B., Ozkara, C., Ozer, F., Ozer, S., Hanoglu, L., Zunker, P., Pozo, J. L., Oberwittler, C., Schick, A., Buschmann, H. -Ch., Ringelstein, E. Bernd, Lara, M., Anzola, G. P., Magoni, M., Volta, G. Dalla, Tarasov, A., Feigin, V., Beaudry, M. G., Carrier, S., Chicoutimi, Henriques, I. L., Bogoussslavsky, J., van Melle, G., Mathieu, J., Perusse, L., Allard, P., Prevost, C., Cantin, L., Bouchard, J. M., De Braekeleer, M., Agbo, C., Neau, J. P., Tantot, A. M., Dary-Auriol, M., Ingrand, P., Gil, R., Baltadjiev, D., Zekin, D., Sabey, K., Gennaula, C. P., Pope, B. A., Caparros-Lefebvre, D., Girard-Buttaz, I., Pruvo, J. P., Petit, H., Hipola, D., Martin, M., Giménez-Roldan, S., Ivanez, V., Japaridze, G., Carrasco, J. L., Picomell, I., Herranz, J. L., Macias, J. A., Nieto, M., Noya, M., Oller, L., Kiteva-Trencevska, G., Delgado, M. R., Liu, H., Luengo, A., Parra, J., Colas, J., Fernandez, M. J., Manzanares, R., Kornhuber, M. E., Malashkhia, V., Orkodashili, G., Martinez, M., Bonaventura, I., Porta, G., Martinez, I., Fernandez, A., Aguilar, M., Masnou, P., Drouet, A., Dreyfus, M., Cartron, J., Morel-Kopp, M. C., Tchernia, G., Kaplan, C., Lammers, M. W., Hekster, Y. A., Keyser, A., Meinardi, H., Renier, W. O., Boon, P. A. J. M., Have, M. D., Kint, B., Cruz, P., Cadilha, A., Almeida, R., Goncalves, M., Pimenta, M., Ramos, L. M. P., Polder, T. W., Broere, C. A., Polman, L., Rother, I., Rother, M., Schlaug, G., Arnold, S., Holthausen, H., Wunderlich, G., Ebner, A., Luders, H., Witte, O. W., Seitz, R. J., Serra, L. L., Gallicchio, B., Rotondi, F., Wieshmann, U., Meierkord, H., Sabev, K., Di Carlo, V., Gueguen, B., Derouesné, Ch., Ancri, D., Bourdel, M. C., Guillou, S., Aliaga, R., Chornet, M. A., Rodrigo, A., Pascual, A. Pascual -Leone, Catala, M. D., Pascual-Leone, A., Benbadis, S. R., Dinner, D. S., Chelune, G. J., Lüders, H. O., Piedmonte, M. R., Blanco, T., Lopez, M. P., Romero, B., Deltoro, A., Pascual, A., Pascual, Leone, Bolgert, F., Josse, M. O., Tassan, P., Touze, E., Laplane, D., Godenberg, F., Brizioli, E., Del Gobbo, M., Pelliccioni, G., Scarpino, O., Durak, H., Damlacik, G., Tunca, Z., Fidaner, H., Yurekli, Y., Yemez, B., Kaygisiz, A., Anllo, E. A., Esperet, E., Giovagnoli, A. R., Casazza, M., Spreafico, R., Avanzini, G., Mascheroni, S., Vecchio, I., Tornali, C., Antonuzzo, A., Grasso, A. A., Bella, R., Pennisi, G., Raffaele, R., Broeckx, J., Schildermans, F., Hospers, W., Deberdt, W., Carney, J. M., Aksenova, M., Chen, M. S., Juncadella, M., Busquets, N., De la Fuente, I., Rodriguez, A., Rubio, F., Soler, R., Khati, C., Pillon, B., Deweer, B., Malapani, C., Malichard, N., Dubois, B., Rancurel, G., Lopez, D. L., Jungreia, G., DeKosky, S. T., Boiler, F., Weiller, C., Rijntjes, M., Mueller, S. P., Maguire, E. A., Burke, E. T., Staunton, H., Phillips, J., Rousseaux, M., Pena, J., Bertran, I., Santacruz, P., Lopez, R., Catafau, A., Lomena, F., Blesa, R., Rampello, L., Nicoletti, A., Cabaret, M., Lesoin, F., Steinling, M., Tournev, I., Maier-Hauff, K., Schroeder, M., Wolf, A., Cochin, J. P., Noel, I., Augustin, P., Auzou, P., Hannequin, D., Maria, V., Lopez-Bresnahan, Danielle, D. M., Antin-Ozerkis B. A., Bartels, E., Rodiek, S. O., Flugel, K. A., Campos, D. M., Salas-Puig, J., Del Rio, J. Sanhez, Vidal, J. A., Lahoz, C. H., Eraksoy, M., Barlas, O., Barlas, M., Bayindir, C., Ozcan, H., Birbamer, G., Gerstenbrand, F., Felber, S., Luz, G., Aichner, F., Seidel, G., Kaps, M., Hutzelmann, A., Gerriets, T., Kruggel, F., Martin, P. J., Gaunt, M. E., Abbot, R. J., Naylor, A. R., Meary, E., Dilouya, A., Meder, J. F., De Recondo, J., Lebtahi, R., Neff, K. W., Meairs, S., Viola, S., Matta, E., Aquilone, L., Rise, I. R., Authier, F. J., Kondo, H., Ghnassia, R. T., Degos, J. D., Gherardi, R. K., Bardoni A., Ciafaloni E., Comi G. P., Bresolin N., Robotti M., Moggio M., Rigoletto C., Roses A., Scarlato G., Castelli, E., Turconi, A., Bresolin, N., Perani, D., Felisari, G., Chariot, P., de Pinieux, G., Astier, A., Jacotot, B., Gherardi, R., Fischer-Gagnepain, V., Louboutin, J. P., Crespo, F., Florea-Strat, A., Fromont, G., Sabourin, J. -C., Gonano, E. -F., Moroni, I., Prelle, A., Iannaccone, S., Quattrini, A., deRino, F., Sessa, M., Golzi, V., Smirne, S., Nemni, R., Turpin, J. C., Lucotte, G., Jacobs, S. C. J. M., Willems, P. W. A., Bootsma, A. L., Lasa, A., Calaf, M., Baiget, M., Gallano, B., Fichter-Gagnepain, V., Mazzucchelli, F., D'Angelo, M. G., Velicogna, M., Bet, L., Comi, G. P., Bordoni, A., Gonano, E. F., Bazzi, P., Rapuzzi, S., Moggio, M., Fagiolari, G., Ciscato, P., Messina, A., Battistel, A., Ryniewicz, B., Sangla, I., Desnuelle, C., Paquis, V., Cozzone, P. J., Bendahan, D., Sturenburg, H. J., Kohncke, G., Castellli, E., Linssen, W., Stegeman, D., Binkhorst, R., Notermans, S., Jaspert, A., Fahsold, R., de Munain, A. Lopez, Cobo, A., Martorell, L., Poza, J. J., Navarrete Palau, D., Emparanza, J. I., Sanchez-Roy, R., Vilchez, J. J., Hernandez, M., Tena, J. Garcia, Perla, C., Koutroumanidis, M., Papathanasopoulos, P., Papadimitriou, A., Papapetropoulos, T. H., Divari, R., Hadjigeorgiou, G. M., Anastasopoulos, I., Sansone, V., Rotondo, G., Meola, G., Rigoletto, C., Messina, S., Szwabowska-Orzeszko, E., Jozwiak, S., Michalowicz, R., Szaplyko, W., Petrella, M. A., Della Marca, G., Masullo, G., Mennuni, G. F., Kompf, D., Wascher, E., Verleger, R., Kaido, M., Soga, F., Toyooka, H., Bayon, C., Rubio, J., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Bonavita, V., Pentore, R., Venneri, A., Pasquier, F., Lebert, F., Grymonprez, L., Lefebvre, C., Van der Linden, M., Derouesné, C., Renault, B., Lacomblez, L., Homeyer, P., Ouss, L., Neuman, E., Malbezin, M., Barrandon, S., Guez, D., Stevens, M., van Swieten, J. C., Franke, C. L., Sanchez, A., Castellvirel, S., Mila, M., Jimenez, D., Pallesta, F., Ruiz, P. J. Garcia, Barrio, A., Barroso, T., Benitez, J., de Yebenes, J. Garcia, Manubens, J. M., Martinez-Lage, J. M., Larumbe, R., Muruzabal, J., Lacruz, F., Quesada, Pedro, Gallego, J., Ferini-Strambi, L., Marcone, A., Garancini, P., Tedesi, B., Jacob, B., Rozewicz, L., Langdon, D., Davie, C., Ron, M., Thompson, A., Koepp, M. J., Hansen, M. L., Guldin, B., Pressler, R. M., Ried, S., Scholz, C., Monaco, F., Gianelli, M., Schiavalla, M. P., Naldi, P., Cantello, R., Torta, R., Verze, L., Mutani, R., Knott, H., Ferbert, A., Schulze-Bonhage, A., Aust, W., Di Mascio, R., Marchioli, R., Vitullo, F., Di Pasquale, A., Sciulli, L., Kramer, V., Tognoni, G., Santacruz, P., Lopez, R., Marti, M. J., Charques, I., Catafau, A., Lomeila, F., Peila, J., Bertran, I., Blesa, R., Krendel, D. A., Costiga, D. A., Koeppen, S., Korn, W. M., Brugge, S., Schmitz, D., Scheulen, M. E., King, R. H. M., Robertson, A. M., Thomas, P. K., Kerkhofs, A., Vermersch, P., Dereeper, O., Daems Monpeun, C., Parent, M., Deplanque, D., Petit, H., Campero, M., Serra, J., Ochoa, J. L., Martinez-Matos, J. A., Montero, J., Olivé, M., Rene, R., Vidaller, A., Gugenheim, M., Gouider, R., Le Guern, E., Brice, A., Agid, Y., Bouche, P., Grisold, W., Ziflo, U., Drlicek, M., Budka, H., Jellinger, K., Zielinski, C. H., Ginsberg, L., King, R. H. M., Workman, J., Platts, A. D., Thomas, P. K., Gherardi, R. K., Florea-Strat, A., Poron, F., Sabourin, J. -C., Fazio, R., Nemni, R., Franceschi, M., Lorenzetti, I., Rinaldi, L., Canal, N., Weilbach, F. X., Sennlaub, A., Jung, S., Gold, R., Toyka, K. V., Hartung, H. P., Giegerich, G., Ellie, E., Vital, A., Steck, A. J., Vital, C., Julien, J., Doneda, P., Pizzul, S., Scarpini, E., Chiodi, P., Ramacci, M. T., Livraghi, S., Maimone, D., Annunziata, P., Salvadori, C., Guazzi, G. C., Arne-Bes, M. C., Delisle, M. B., Fabre, N., Hurtevent, J. F., Bes, A., Baudoin-Martin, D., Laborde, E., Viallet, F., Creisson, C., Crespi, V., Bogliun, G., Marzorati, L., Zincone, A., D'Angelo, L., Liberani, A., Merlini, M., Rivolta, R., Creange, A., Sabourin, J. -C., Theodorou, I., Gherardi, R. K., Conti, A. M., Malosio, M. L., Baron, P. L., Scarlato, G., Chorao, R., Rosas, M. J., Leite, I., Callea, L., Donati, E., Bargnani, C., Bud, M., Verdu, E., Navarro, X., Braun, S., Einius, S., Poindron, P., Warier, J. M., Bradley, J., Bekkelund, S. I., Torbergsen, T., Mellgren, S. I., Carlomagno, S., Parlato, V., Santoro, A., Lavarone, A., Boller, F., Bonavita, V., Engelhardt, A., Lörler, H., Robeck, S., Kluglein, C., Comi, G., Avoledo, V., Locatelli, T., Leocani, L., Galardi, G., Magnani, G., Medaglini, S., Chkhikvishvili, T. S., Zangaladze, A., Bratoeva, M., Kovachev, P., Chavdarov, D., Artemis, N., Karacostas, D., Milonas, I., Arpa, J., Lopez-Pajares, R., Cruz-Matinez, A., Sarria, J., Palomo, F., Alonso, M., Rodriguez-Al-barino, A., Lacasa, T., Nos, J., Barreiro, P., Martinez, A. Cruz, Villoslada, C., Alons, M., Taghavy, A., Hamer, H., Kratzer, A., Dethy, S., Pauwels, T., Monclus, M., Luxen, A., Goldman, S., Ziegler, M., Crambes, O., Ragueneau, I., Arnaud, F., Zappia, M., Montesanti, R., Colao, R., Palmieri, A., Branca, D., Nicoletti, G., Rizzo, M., Parlato, G., Quattrone, A., Vanacore, N., Zuchegna, P., Bonifati, V., Meco, G., Scholz, J., Friedrich, H. -J., Rohl, A., Ulm, G., Vieregge, P., Savettieri, G., Rocca, W. A., Meneghini, F., Grigoletto, F., Morgante, L., Reggio, A., Salemi, G., Di Pierri, R., OzckmekÇi, S., Ertan, S., Yeni, N., Apaydin, H., Erkol, G., Kiziltan, G., Denktas, F., Ranoux, D., de Recondo, J., Ostergaard, L., Werdelin, L., Odin, P., Lindvall, O., Dupont, E., Christensen, P. B., Boisen, E., Jensen, N. B., Schmiegelow, M., Ingwersen, S. H., Matias-Guiu, J., Canet, T., Falip, R., Martin, R., Galiano, L., Voloshin, M. Y., Burchinskaya, L. F., Cabrera-Valdivia, F., Jimenez-Jimenez, F. J., Molina, J. A., Fernandez-Calle, P., Vazquez, A., Canizares-Liebana, F., Larumbe-Lobalde, S., Ayuso-Peralta, L., Rabasa, M., Codoceo, R., Arrieta, F. J., Aguilar, M. V., Jorge-Santamaria, A., Martinez-Para, M. C., Alarcon, J., Mateo, D., Gimenez-Roldan, S., Gencheva, E., Tzonev, T. z., Georgiev, G., Petkova, P., Gasparini, M., Vanacore, N., Meco, N. G., de la Sierra, G., Aguado, F., Revilla, M., Varela, L., Rico, H., Feve, A., N'Guyen, J. P., Bathien, N., Fenelon, G., Veroust, J., Cesaro, P., Egersbach, G., Hattig, H., Schelosky, L., Wissel, J., Poewe, W., Durif, F., Albuisson, E., Debilly, B., Tournilhac, M., Magnani, C., Mocellini, C., Soffietti, R., Schiffer, D., Cardozo, A., Cruz-Sanchez, F. F., Falip, L., Potagas, G., Ziegler, M., Rondot, P., Bonifati, V., Fabrizio, E., Meco, G., Bostantjopoulou, S., Katsarou, Z., Kyriazis, G., Baas, H., Demisch, L., Esser, A., Zoeller, F., Burklin, F., Harder, S., Fischer, P. A., Arcusa, M. J., Hermandez, S., Claramonte, F. J., Pascual, A. Pascual- Leone, Alonso, M. D., Catata, M. D., Alessandri, A., Giustini, P., Dufour, A., Ciusani, E., Nespolo, A., Roelcke U., Radu E. W., von Ammon K., Maguire R. P., Leenders K. L., Radionova, M., Chavdarov, D., Bratoeva, M., Tzekov, Ch., Pietrangeli, A., Bove, L., Pace, A., Falqui, L., Jandolo, B., Potemkowski, A., Muller B., Reinhard I., Krone A., Warmuth M., Brocker E. M., Krauseneck P., Meyding-Lamadé, U., Krieger, D., Sartor, K., Hacke, W., Maugard-Louboutin, C., Fayet, G., Sagan, C., Martin, S., Ménégalli, D., Lajat, Y., Resche, F., Koriech, O. M., Al Moutaery, K., Yaqub, B., Jochens, R., Wolters, A., Venz, S., Cordes, M., Hecht, B. K., Chatel, M., Gaudray, P., Turc-Carel, C., Gioanni, J., Ayraud, N., Hecht, F., Rumbach, L., Racadot, E., Bataillard, M., Billot, M., Pariset, J., Wijdenes, J., Montalban, Rio J., Tintoré, M., Galan, I., Acarin, N., Rapaport, S., Huberman, M., Shechtcr, D., Karabudak, R., Kilinc, M., Boyacigil, S., Cila, A., Polo, J. M., Setien, S., Sanchez, R., Figols, J., Zubimendi, A., Nadareishvili, Z. G., Massot, R., Marés, R., Gallecho, F., Richart, C., Hernandez, M. A., Garcia, M. R., Lorenzo, J. N., Leon, C., Muros, M., Togores, J., Kutluk, K., Damlacik, G. A., Tekinsoy, B., Obuz, O., Baklan, B., Idiman, E., Genc, K., Zielasek, J., Schmidt, B., Liew, F. Y., Gulay, Z., Yulug, N., Wong, K. S., Wong, T. W., Yu, T. S., Kay, R., Poupon, R., Giral, P., Roberti, C., Zanette, E. M., Chiarotti, F., Brusa, L., Cerbo, R., Prusinski, A., Pondal, M., Canton, R., Dominigo, Erodriguez J., Pereira Monteino J. M., Pereira Monteino X., Pardo, J., Carroacedo, A., Barros, F., Lema, M., Castillo, J., Melchor, A., Montiel, I., Guiu, J. Matias, Kloss, T. M., Keidel, M., Jacob, M., Idiman, F., Idman, E., Ozturk, V., Metin, E., Yilmaz, M., Gerard, J. M., Bouton, R., Decamps, D., Herbaut, A. G., Delecluse, F., Cavenaile, M., Divano, L., Chazot, G., Boureau, F., Emile, J., Bertin, L., d'Allens, H., Ferro, J. M., Costa, I., Carletto, F., Catarci, T., Padovani, A., Iandolo, B., Bartoli, M., Bonamini, M., Pulcinelli, F., Pignatelli, P., Russo, M., Gazzaniga, P. P., Barros, J., Pinheiro, J., Correia, A. P., Monteiro, J. M. Pereira, Alvarez-Cermeno, J. C., Avello, G., Sastre, J. L., Vecino, A., Cesar, J. M., Leone, M., Stankov, B., D'Amico, D., Maltempo, C., Moschian, F., Fraschini, F., Bussone, G., Molto, J. M., Fernandez, E., Fernandez, A. Morento, Barreiro, A., Siclia, J., Castejon, P., Mihout, B., Malberin, M., Salzman, V., Bogousslavsky, J., Meneghetti, G., Baracchini, C., Bozzato, G., Marini, B., Mendel, T., Czlonkowska, A., Pasierski, T., Szwed, H., Marta-Moreno, J., Lopez-Delval, J., Mostacero, E., Morales, F., Mahagne, M. H., Rogopoulos, A., Bertrand, F., Bedoucha, P., Lanteri-Minet, M., Riva, D., Zorzi, C., Milani, N., Vajsar, J., Ronen, G., Macgregor, D., Becker, L., Susseve, J., Seidl, Z., Faber, J., Obenberger, J., Springer, R., Bax, R. T., Eckardt, T., Czettritz, G. V., Emmrich, P., Vlaski-Jekic, S., Petrova, V., Cherninkova, S., Gudeva, T., Tzekov, C., Devoti, M., Franceschetti, S., Mientus, S., Vienna, P., Vashtang, Y., Tazir, M., Assami, S., Oulbani, D., Kaci Ahmed, M. Ait, Andersen, G., Vestergaard, K., Riis, J. O., Chavdarov, D., Corbo, M., Previtali, S., Allen, R. R., McKay, W. C., Rowbotham, M. C., Castellvi-Pel, S., Banchs, I., Kruyer, H., Corral, J., Saugeir-Veber, P., Munnich, A., Bonneau, D., Rozet, J. M., Le Merrer, M., Boespflug-Tanguy, O., Gokyigit, A., Oktem, O., Demir, G., Caliskan, A., Gardiner, R. M., Shorvon, Simon, Wieser, Heinz -Gregor, Hossmann, K. A., Steinberg, A., van Crevel, H., Ducros, A., Labauge, P., Pinsard, N., Ponsot, G., Gouttiere, F., Gastaut, J. L., Delrieu, O., BesanÇon, V., Klopstock, T., May, A., Seibel, P., Papagiannuli, E., Reichmann, H., Gurses, C., Aykut, C., Aktan, S., De Vuono, G., Fiacco, F., Gazzaniga Pozzill, P. P., Assuerus, V., Jacomet, C., Picard, O., Rozenbaum, W., Nueckel, M., Osschmann, P., Horning, C. R., Caldarelli-Stefano, R., Omodeo-Zorini, E., Rivolta, G. E., Maserati, R., Cagni, A., Ferrante, P., Lamadé, W., Heb, Th., Gosztonyl, G., Daral, G., Fresquet, C., Storch-Hagenlocher, B., Wildemann, B., Jager, G., Fuhry, L., Van Paesschen, W., Grunewald, R. A., Duncan, J. S., Connelly, A., Jackson, G. D., Sisodiya, S., Raymond, A. A., Shorvon, S. D., Fish, D. R., Stevens, J. M., Savic, I., Pauli, S., Thorell, J. O., Browne, R. H., Kornhuber, J., Retz, W., Riederer, P., Boon, F., Calliauw, L., Hoksergen, I., Thiery, E., Caemert, J., Decoo, D., Desomer, A., Chevalier, Y., Grinspan, A., Hirsch, E., Moszkowski, J., Marescaux, C., Yaqub, B. A., Valdueza, J. M., Puchner, M. J. A., Dammann, O., Vortmeyer, A., Herrmann, H. -D., Peterson, W., Prevett, M. C., Cunningham, V., Brooks, D. J., Pomes, A., Sunol, C., Durwen, H. F., Confavreux, Ch., Grimaud, J., Saddier, P., Moreau, T., Cortinovis-Tourniaire, P., Aimard, G., Adeleine, P., Paty, D. W., Wiles, C. M., Midgard, R., Riise, T., Kvale, G., Nyland, H., Stodal, H., Haase, A., Lassmann, H., Deeb, S. M. Al., Bruyn, G. W., Semana, G., Teisserenc, H., Alizadeh, M., Loiseau, P., Birebent, B., Yaouanq, J., Genetet, B., Sabouraud, O., Charron, D. J., Shaw, C. E., Stelmasiak, C., Solski, J., Nowicki, J., Jakubowska, B., Ryba, M., Grieb, P., Garcia-Merino, A., Usuku, K., Yunis, E., Alper, C., Hauser, S. L., Betuel, H., Gebuhrer, L., Salier, J. P., Kellar-Wood, H., Govan, G. G., Bromberg, J. E. C., Rinkel, G. J. E., Algra, A., Moulin, T., Stojkovic, T., Chavrot, D., Klotzsch, C., Kaiser-Rub, K., Nahser, H. C., Klijn, C. J. M., Tulleken, C. A. F., Rappelle, L. J., Daffertshofer, M., Kother, J., Hornig, C. R., Rust, D. S., Busse, O., Laun, A., Corabianu, O., Berbinschi, A., Chastang, C., Cophignon, J., Haguenau, M., Ketelslegers, J. M., Jander, S., Kramer, M., Schröter, M., Witte, O. W., Stoll, G., Möbner, R., Barak, V., Sarova-Ponchas, I., Holon, Le Coz, P., Woimant, F., George, B., Merland, J. J., Chleide, E., Casademont, J., Barrientos, A., Cardellach, F., Cervantes, F., Grau, J. M., Montoya, J., Rozman, C., Urbano-Marquez, A., Nunes, V., Lane, R. J. M., Archard, L. C., Schapira, A. H. V., Cooper, J. M., Barnes, P. R. J., Kemp, G. 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M., Pleiffer, G., Kunre, K., Dieterich, M., Brandt, Th., Guarino, M., Stracciari, A., Pazzaglia, P., D'Alessandro, R., Santilli, I., Donato, M., The European Velnacrine Study Group, The Dutch Guillain-Barré study group, The COP-1 Multicenter Clinical and Research Group Study, and European Study Group
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- 1994
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157. Clinically definite multiple sclerosis after radiological Schilder-like onset
- Author
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Sastre-Garriga, MD, J., Rovira, MD, PhD, A., Río, MD, PhD, J., Tintoré, MD, PhD, M., Grivé, MD, PhD, E., and Montalban, MD, PhD, X.
- Published
- 2003
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158. Cassava (Manihot esculentaCrantz) and maize (Zea maysL.) flour mixtures for the development of healthy snacks
- Author
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Euan-Pech, Emmanuel, Chel-Guerrero, Luis, Rodríguez-Canto, Wilbert, Gallegos-Tintoré, Santiago, and Betancur-Ancona, David
- Abstract
In recent years, there has been an excess in the consumption of products with high fat content and low nutritional value, such as fried snacks, which have been related to several chronic degenerative diseases; therefore, it is necessary to look for alternatives to improve the nutritional value of snacks to make them healthy and appetizing. Baked chips with cassava flour and different substitution levels of maize flour were made to evaluate the effect of this substitution on the quality of the snacks produced. Three treatments based on the substitution of cassava flour with maize flour at levels of 0, 20, and 40%, each with three replicates, were done. The response variables were the chemical composition: moisture, ash, fat, protein and fiber, niacin content, energy intake, breaking strength, and level of palatability based on sensory evaluation. Higher protein (∼8.3%) and niacin content (∼0.8 mg/100 g) after baking were obtained as the level of maize flour substitution increased. The lower caloric density (∼380 kcal/100g) was achieved by a reduction in the fat content attributed to the baking process compared to fried products. Crunchiness of the snacks, expressed as breaking strength (∼3.7 kgf), increased as the level of flour substitution increased, and the sensory evaluation indicated that the snacks formulated with a substitution level of 40% maize flour were liked the best. The possibility of using mixtures of cassava (Manihot esculenta) and maize (Zea mays) flours can be a viable and innovative alternative for the production of healthy snacks in the culinary industry.
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- 2024
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159. Actividad antioxidante y quelante de sistemas hidrocoloides mixtos formados por hidrolizados proteicos de Phaseolus vulgaris endurecido y goma modificada de flamboyán (Delonix regia).
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Gallegos Tintoré, Santiago, Guzmán Mendez, Beatriz Eugenia, Jaramillo Flores, María Eugenia, Chel Guerreo, Luis, and Betancur Ancona, David
- Abstract
Copyright of Archivos Latinoamericanos de Nutrición is the property of Sociedad Latinoamericana de Nutricion and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2021
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160. Incidence and risk factors of exacerbations among COPD patients in primary health care: APMPOC study
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Domènech Cristina, Mezquiriz Xavier, Negrete Antonio, Puigfel Yolanda, Urrea Magalí, Monteagudo Mònica, Montellà Núria, Pera Guillem, Muñoz Laura, Torán Pere, Rodríguez Mar, Borrell Eulàlia, Lacasta Anna, García Ma Llum, Maneus Sandra, and Tintoré Glòria
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Worldwide, chronic obstructive pulmonary disease (COPD) is the fourth cause of death. Exacerbations have a negative impact on the prognosis of COPD and the frequency and severity of these episodes are associated with a higher patient mortality. Exacerbations are the first cause of decompensation, hospital admission and death in COPD. The incidence of exacerbations has mainly been estimated in populations of patients with moderate-severe COPD requiring hospital care. However, little is known regarding the epidemiology of exacerbations in patients with less severe COPD forms. It is therefore possible that a high number of these less severe forms of exacerbations are underdiagnosed and may, in the long-term, have certain prognostic importance for the COPD evolution. The aim of this study was to know the incidence and risk factors associated with exacerbations in patients with COPD in primary care. Methods and design A prospective, observational, 3-phase, multicentre study will be performed involving: baseline evaluation, follow up and final evaluation. A total of 685 smokers or ex-smokers from 40 to 80 years of age with COPD, without acute respiratory disease or any other long-term respiratory disease will be randomly selected among the population assigned to 21 primary care centres. The diagnosis of COPD and its severity will be confirmed by spirometry. Information regarding the baseline situation, quality of life and exposure to contaminants or other factors potentially related to exacerbations will be collected. A group of 354 patients with confirmed COPD of varying severity will be followed for one year through monthly telephone calls and daily reporting of symptoms with the aim of detecting all the exacerbations which occur. These patients will be evaluated again at the end of the study and the incidence of exacerbations and associated relative risks will be estimated by negative binomial regression. Discussion The results will be relevant to provide knowledge about natural history of the initial phases of the COPD and the impact and incidence of the exacerbations on the patients with mild-moderate forms of the disease. These data may be important to know the milder forms of exacerbation wich are often silent or very little expressed clinically.
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- 2009
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161. Serum neurofilament light chain levels predict long-term disability progression in patients with progressive multiple sclerosis
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Comabella, Manuel, Sastre-Garriga, Jaume, Carbonell-Mirabent, Pere, Fissolo, Nicolás, Tur, Carmen, Malhotra, Sunny, Pareto, Deborah, Aymerich, Francesc X, Río, Jordi, Rovira, Alex, Tintoré, Mar, and Montalban, Xavier
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ObjectiveThere is a lack of sensitive and specific biomarkers for use in progressive multiple sclerosis (MS). The study aimed to assess the potential of serum neurofilament light chain (sNfL) levels as biomarker of disability progression in patients with progressive MS.MethodsWe performed a prospective observational cohort study in 51 patients with progressive MS who participated in a 2-year phase II single-centre, randomised, double-blind, placebo-controlled trial of interferon-beta. Mean (SD) follow-up duration was 13.9 (6.2) years. Levels of sNfL were measured using a single molecule array immunoassay at baseline, 1, 2 and 6 years. Univariable and multivariable analyses were carried out to evaluate associations between sNfL levels and disability progression at short term (2 years), medium term (6 years) and long term (at the time of the last follow-up).ResultsA sNfL cut-off value of 10.2 pg/mL at baseline discriminated between long-term progressors and non-progressors with a 75% sensitivity and 67% specificity (adjusted OR 7.8; 95% CI 1.8 to 46.4; p=0.01). Similar performance to discriminate between long-term progressors and non-progressors was observed using age/body mass index-adjusted sNfL Z-scores derived from a normative database of healthy controls. A cut-off increase of 5.1 pg/mL in sNfL levels between baseline and 6 years also discriminated between long-term progressors and non-progressors with a 71% sensitivity and 86% specificity (adjusted OR 49.4; 95% CI 4.4 to 2×103; p=0.008).ConclusionssNfL can be considered a prognostic biomarker of future long-term disability progression in patients with progressive MS. These data expand the little knowledge existing on the role of sNfL as long-term prognostic biomarker in patients with progressive MS.
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- 2022
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162. Optic Nerve Topography in Multiple Sclerosis Diagnosis: The Utility of Visual Evoked Potentials.
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Vidal-Jordana, Angela, Rovira, Alex, Arrambide, Georgina, Otero-Romero, Susana, Río, Jordi, Comabella, Manuel, Nos, Carlos, Castilló, Joaquin, Galan, Ingrid, Cabello, Sergio, Moncho, Dulce, Rahnama, Kimia, Thonon, Vanessa, Rodríguez-Acevedo, Breogan, Zabalza, Ana, Midaglia, Luciana, Auger, Cristina, Sastre-Garriga, Jaume, Montalban, Xavier, and Tintoré, Mar
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- 2021
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163. CSF 14-3-3 protein assay and MRI as prognostic markers in patients with a clinically isolated syndrome suggestive of MS
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Martínez-Yélamos, A., Rovira, A., Sánchez-Valle, R., Martínez-Yélamos, S., Tintoré, M., Blanco, Y., Graus, F., Montalban, X., Arbizu, T., and Saiz, A.
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- 2004
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164. Serial gadolinium-enhanced MRI in acute attack of multiple sclerosis treated with plasma exchange
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Pericot, Imma, Río, Jordi, Rovira, Alex, Castellà, M. Dolors, Tintoré, Mar, and Montalban, Xavier
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- 2003
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165. Polyglandular autoimmune syndrome type II and multiple sclerosis
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Sastre-Garriga, J., Tintoré, M., and Montalban, X.
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- 2001
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166. Lower motor neuron disease in a HIV-2 infected woman
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Sastre-Garriga, J., Tintoré, M., Raguer, N., Ruíz, I., Montalban, X., and Codina, A.
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- 2000
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167. Reply
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Puig-Tintoré, L. M. and Vidal-Sicart, S.
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- 2007
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168. Recomendaciones para la vacunación en pacientes con esclerosis múltiple candidatos a terapias inmunosupresoras: documento de consenso español
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Otero-Romero, S., Rodríguez-García, J., Vilella, A., Ara, J.R., Brieva, L., Calles, C., Carmona, O., Casanova, V., Costa-Frossard, L., Eichau, S., García-Merino, J.A., Garcia-Vidal, C., González-Platas, M., Llaneza, M., Martínez-Ginés, M., Meca-Lallana, J.E., Prieto, J.M., Rodríguez-Antigüedad, A., Tintoré, M., Blanco, Y., and Moral, E.
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La reciente aparición de terapias de alta efectividad para el tratamiento de la esclerosis múltiple (EM), con potencial riesgo de complicaciones infecciosas, obliga plantear estrategias de prevención y minimización de riesgos. La vacunación constituye una parte esencial del manejo de estos pacientes. Este consenso recoge una serie de pautas y escenarios prácticos de vacunación en pacientes adultos con EM candidatos a tratamiento inmunosupresor.
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- 2021
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169. Copernicus Marine Service Ocean State Report, Issue 4
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von Schuckmann, Karina, Le Traon, Pierre-Yves, Smith, Neville, Pascual, Ananda, Djavidnia, Samuel, Gattuso, Jean-Pierre, Grégoire, Marilaure, Nolan, Glenn, Aaboe, Signe, Fanjul, Enrique Álvarez, Aouf, Lotfi, Aznar, Roland, Badewien, T. H., Behrens, Arno, Berta, Maristella, Bertino, Laurent, Blackford, Jeremy, Bolzon, Giorgio, Borile, Federica, Bretagnon, Marine, Brewin, Robert J.W., Canu, Donata, Cessi, Paola, Ciavatta, Stefano, Chapron, Bertrand, Trang Chau, Thi Tuyet, Chevallier, Frédéric, Chtirkova, Boriana, Ciliberti, Stefania, Clark, James R., Clementi, Emanuela, Combot, Clément, Comerma, Eric, Conchon, Anna, Coppini, Giovanni, Corgnati, Lorenzo, Cossarini, Gianpiero, Cravatte, Sophie, de Alfonso, Marta, de Boyer Montégut, Clément, De Lera Fernández, Christian, de los Santos, Francisco Javier, Denvil-Sommer, Anna, de Pascual Collar, Álvaro, Dias Nunes, Paulo Alonso Lourenco, Di Biagio, Valeria, Drudi, Massimiliano, Embury, Owen, Falco, Pierpaolo, d’Andon, Odile Fanton, Ferrer, Luis, Ford, David, Freund, H., León, Manuel García, Sotillo, Marcos García, García-Valdecasas, José María, Garnesson, Philippe, Garric, Gilles, Gasparin, Florent, Gehlen, Marion, Genua-Olmedo, Ana, Geyer, Gerhard, Ghermandi, Andrea, Good, Simon A., Gourrion, Jérôme, Greiner, Eric, Griffa, Annalisa, González, Manuel, Griffa, Annalisa, Hernández-Carrasco, Ismael, Isoard, Stéphane, Kennedy, John J., Kay, Susan, Korosov, Anton, Laanemäe, Kaari, Land, Peter E., Lavergne, Thomas, Lazzari, Paolo, Legeais, Jean-François, Lemieux, Benedicte, Levier, Bruno, Llovel, William, Lyubartsev, Vladyslav, Le Traon, Pierre-Yves, Lien, Vidar S., Lima, Leonardo, Lorente, Pablo, Mader, Julien, Magaldi, Marcello G., Maljutenko, Ilja, Mangin, Antoine, Mantovani, Carlo, Marinova, Veselka, Masina, Simona, Mauri, Elena, Meyerjürgens, J., Mignot, Alexandre, McEwan, Robert, Mejia, Carlos, Melet, Angélique, Menna, Milena, Meyssignac, Benoît, Mouche, Alexis, Mourre, Baptiste, Müller, Malte, Notarstefano, Giulio, Orfila, Alejandro, Pardo, Silvia, Peneva, Elisaveta, Pérez-Gómez, Begoña, Perruche, Coralie, Peterlin, Monika, Poulain, Pierre-Marie, Pinardi, Nadia, Quilfen, Yves, Raudsepp, Urmas, Renshaw, Richard, Révelard, Adèle, Reyes-Reyes, Emma, Ricker, M., Rodríguez-Rubio, Pablo, Rotllán, Paz, Gelabert, Eva Royo, Rubio, Anna, Ruiz-Parrado, Inmaculada, Sathyendranath, Shubha, She, Jun, von Schuckmann, Karina, Solidoro, Cosimo, Stanev, Emil V., Staneva, Joanna, Storto, Andrea, Su, Jian, Bakhsh, Tayebeh Tajalli, Tilstone, Gavin H., Tintoré, Joaquín, Toledano, Cristina, Tournadre, Jean, Tranchant, Benoit, Uiboupin, Rivo, Valcarcel, Arnaud, Valcheva, Nadezhda, Verbrugge, Nathalie, Vrac, Mathieu, Wolff, J.-O., Zambianchi, Enrico, Zielinski, O., Zinck, Ann-Sofie, and Zunino, Serena
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- 2020
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170. Head-to-head drug comparisons in multiple sclerosis: Urgent action needed.
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Tur, Carmen, Kalincik, Tomas, Oh, Jiwon, Sormani, Maria P., Tintore, Mar, Butzkueven, Helmut, Montalban, Xavier, and Tintoré, Mar
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- 2019
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171. Quarterly variability of floating plastic debris in the marine protected area of the Menorca Channel (Spain).
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Ruiz-Orejón, Luis F., Mourre, Baptiste, Sardá, Rafael, Tintoré, Joaquín, and Ramis-Pujol, Juan
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PLASTIC marine debris ,MARINE debris ,MARINE parks & reserves ,PLASTIC scrap - Abstract
Plastic pollution is widespread in all the oceans and seas, representing a significant threat to most of their ecosystems even in marine protected areas (MPAs). This study determines the floating plastic distribution in four different periods between 2014 and 2015 in the recently approved Menorca Channel MPA (Balearic Islands). Plastic debris were persistent during all sampling periods on the surface of the Channel, composed mainly by the microplastic sizes. Average particle abundances ranged from 138,293 i t e m s ⋅ k m − 2 in autumn to 347,793 i t e m s ⋅ k m − 2 during the spring, while weight densities varied from 458.15 g (D W) ⋅ k m − 2 in winter to 2016.67 g (D W) ⋅ k m − 2 in summer. Rigid plastics were the most frequent particles in all the periods analysed (from 89.40%-winter to 94.54%-spring). The high-resolution and particle distribution models corroborated that the oceanographic variability shapes different patterns of presence of plastics, and in particular the existence of areas with almost no plastics. Image 1 • Floating plastic debris were ubiquitous during all periods in the Menorca Channel. • Rigid fragments and microplastic sizes were the dominant typologies. • Maximum values were 347,793 items·km
-2 (spring) and 2016.67 g (DW)·km-2 (summer). • Models corroborate the oceanographic variability that shape particle distribution. Floating plastic debris in the MPA of the Menorca Channel were present along four different sampling periods influenced by circulation patterns that would shape its spatial distribution. [ABSTRACT FROM AUTHOR]- Published
- 2019
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172. Frequency and relevance of IgM, and IgA antibodies against MOG in MOG-IgG-associated disease.
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Pedreño, Marta, Sepúlveda, Maria, Armangué, Thais, Sabater, Lidia, Martínez-Hernandez, Eugenia, Arrambide, Georgina, Blanco, Yolanda, Llufriu, Sara, Martínez-Lapiscina, Elena H., Mulero, Patricia, Sola-Valls, Nuria, Ruiz-García, Raquel, Tintoré, Mar, Dalmau, Josep, Graus, Francesc, and Saiz, Albert
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Highlights • Up to 19% of the seropositive MOG-IgG patients have additional IgA or IgM antibodies. • IgA or IgM MOG antibodies occur in ADEM in pediatric and optic neuritis in adults. • Patients with and without additional IgA or IgM antibodies have similar features/outcome. • IgM and IgA antibodies dynamic along the course of the disease parallel that of MOG-IgG. Abstract Objective To determine the frequency and relevance of IgM, and IgA antibodies against myelin oligodendrocyte glycoprotein (MOG) in MOG-IgG-associated disease. Methods Evaluation of IgM, and IgA MOG antibodies in serum of 120 patients with MOG-IgG (53 pediatric and 67 adults), and 114 patients with seronegative-MOG-IgG (35 children with first demyelinating syndrome, 20 adults with clinically isolated syndrome, and 59 adults with other diseases). Antibodies were examined by cell-based assays. Results IgM or IgA MOG antibodies were identified in 23/120 (19%) patients with MOG-IgG (13/53 [24.5%] pediatric, and 10/67 [15%] adult patients), and 2/114 (1.7%) patients with seronegative-MOG-IgG (2/35 [5.7%] pediatric patients). Of the 25 patients, 14 had IgA, 9 IgM, and 2 both antibodies. Fourteen of the 15 (93%) children with IgM (4), IgA (9), or both (2) had acute demyelinating encephalomyelitis (ADEM), and 7 of the 10 (70%) adults with IgM (5) or IgA (5) had optic neuritis at onset. At the last follow-up, the final diagnoses remained as ADEM in 14 (100%) children and optic neuritis in 6 (86%) adults. The outcome was not different between patients with or without additional classes of antibodies. Conclusion Coexisting IgM and IgA antibodies occurs in 19% of children and adult patients with MOG-IgG-associated disease. The presence of these antibodies does not seem to play a relevant clinical role in the disorder. [ABSTRACT FROM AUTHOR]
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- 2019
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173. Multiple sclerosis risk perception and acceptance for Brazilian patients
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Denis Bernardi Bichuetti, Carolina Azze Franco, Isaac Elias, Andreia C. R. Mendonça, Lorraine Fiama Diniz Carvalho, Denise Sisterolli Diniz, Carmen Tur, Mar Tintoré, and Enedina Maria Lobato de Oliveira
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esclerose múltipla ,natalizumabe ,assunção de riscos ,medição de risco ,tomada de decisões ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
ABSTRACT The perception of multiple sclerosis (MS) severity and risk associated with therapies might influence shared decision making in different countries. We investigated the perception of MS severity and factors associated with risk acceptance in Brazil in 96 patients with relapsing-remitting MS using a standardized questionnaire and compared this with two European cohorts. Multiple sclerosis was perceived as a very severe disease and the risk of developing progressive multifocal leukoencephalopathy due to natalizumab was seen as moderate to high. Seventy-six percent considered a risk of 1:1,000, or higher, an impediment for natalizumab use. Older age was the only variable associated with higher risk acceptance and our patients showed a more conservative profile than German and Spanish patients. Our patients perceived MS severity and progressive multifocal leukoencephalopathy risk similarly to elsewhere, but their willingness to take risks was more conservative. This should be considered when discussing therapeutic options and it might have an impact on guideline adaptations.
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174. Unraveling treatment response in multiple sclerosis: A clinical and MRI challenge.
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Gasperini, Claudio, Prosperini, Luca, Tintoré, Mar, Sormani, Maria Pia, Filippi, Massimo, Rio, Jordi, Palace, Jacqueline, Rocca, Maria A., Ciccarelli, Olga, Barkhof, Frederik, Sastre-Garriga, Jaume, Vrenken, Hugo, Frederiksen, Jette L., Yousry, Tarek A., Enzinger, Christian, Rovira, Alex, Kappos, Ludwig, Pozzilli, Carlo, Montalban, Xavier, and Stefano, Nicola De
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- 2019
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175. SOCIB integrated multi-platform ocean observing and forecasting: from ocean data to sector-focused delivery of products and services
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Heslop, Emma, Tintoré, Joaquín, Rotllan, Paz, Álvarez-Berastegui, Diego, Fontera, Biel, Mourre, Baptiste, Gómez-Pujol, Lluís, March, David, Casas, Benjamin, Nolan, Glenn, and Durand, Dominique
- Abstract
ABSTRACTIn the last 10 years, new monitoring and modelling technologies have emerged allowing real-time observation and forecasting of the coastal ocean at regional and local scales. These technologies are at the core of multi-platform integrated observing and forecasting systems, such as the Balearic Islands Coastal Ocean Observing and Forecasting System (SOCIB). New capabilities to characterise the state of the ocean and its variability at finer spatial and temporal scales are emerging, supporting science and products for society.SOCIB has a well-defined mission to deliver ocean observing for the benefit of science and society. From initiation in 2010, SOCIB has provided high-quality, free and open data. In order to increase our utility, we developed a Products and Services Strategy rooted in business best practice. Ten sectors – groups of users with common data needs – were identified, for which SOCIB has information and knowledge of high value. Dedicated products were developed in cooperation with the end-users: beach lifeguards/managers and sustainable marine resources managers. We illustrate an integrative approach, combining business concepts with collaborative software development methodologies and ocean observing science, to turn ocean observations and forecasts into products and services, with benefits for society in the sustainable blue economy era.
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- 2019
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176. Effects of Oceanic Mesoscale and Submesoscale Frontal Processes on the Vertical Transport of Phytoplankton
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Ruiz, Simón, Claret, Mariona, Pascual, Ananda, Olita, Antonio, Troupin, Charles, Capet, Arthur, Tovar‐Sánchez, Antonio, Allen, John, Poulain, Pierre‐Marie, Tintoré, Joaquín, and Mahadevan, Amala
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Oceanic fronts are dynamically active regions of the global ocean that support upwelling and downwelling with significant implications for phytoplankton production and export. However (on time scales ≳the inertial time scale), the vertical velocity is 103–104times weaker than the horizontal velocity and is difficult to observe directly. Using intensive field observations in conjunction with a process study ocean model, we examine vertical motion and its effect on phytoplankton fluxes at multiple spatial horizontal scales in an oligotrophic region in the Western Mediterranean Sea. The mesoscale ageostrophic vertical velocity (∼10 m/day) inferred from our observations shapes the large‐scale phytoplankton distribution but does not explain the narrow (1–10 km wide) features of high chlorophyll content extending 40–60 m downward from the deep chlorophyll maximum. Using modeling, we show that downwelling submesoscale features concentrate 80% of the downward vertical flux of phytoplankton within just 15% of the horizontal area. These submesoscale spatial structures serve as conduits between the surface mixed layer and pycnocline and can contribute to exporting carbon from the sunlit surface layers to the ocean interior. High‐resolution observations and numerical simulations of mesoscale and submesoscale features at an intense oceanic frontVertical velocities associated with submesoscale features are significantly higher than on the mesoscaleDownwelling submesoscale features concentrate 80% of downward flux of phytoplankton within 15% of the surface area
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- 2019
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177. Temporal and Spatial Hydrodynamic Variability in the Mallorca Channel (Western Mediterranean Sea) From 8 Years of Underwater Glider Data
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Barceló‐Llull, Bàrbara, Pascual, Ananda, Ruiz, Simón, Escudier, Romain, Torner, Marc, and Tintoré, Joaquín
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Eight years of glider data are used to characterize the temporal and spatial variability of a region in the western Mediterranean that will constitute one of the targets for the calibration phase of the Surface Water and Ocean Topography (SWOT) satellite mission. The characteristic horizontal dimension of mesoscale instabilities in the Mallorca channel is 6.0 km. The temporal evolution of intermediate water masses is dominated by an increase over time of the characteristic temperature values. Western Mediterranean and Levantine Intermediate waters display an increase of the temperature extrema of 0.064 ± 0.002 and 0.044 ± 0.002 °C/year between 2011 and 2018, respectively. At the layer of Levantine Intermediate water the salinity temporal regression reveals a mean trend of 0.010 year−1. Temperature annual cycle shows an averaged temperature gradient of ∼6 °C in 6 months at the upper layer, with a disconnection with the annual cycle at 100‐m depth. The circulation across the channel is dominated by high‐frequency variability. The signature of eddies with radius ranging from 5 to 18 km is apparent in 16% of the transects analyzed and mainly in spring and summer, with a dominance of subsurface cyclonic eddies. Two‐way flow controls the annual cycle of the water transport through the channel with prevalence of the inflow of Atlantic water. Variations of water transport over timescales of weeks to months can be similar to those identifiable as seasonal changes. Eight years of glider data are used to characterize the temporal and spatial variability of a region in the western Mediterranean that will constitute one of the targets for the calibration phase of the forthcoming Surface Water and Ocean Topography (SWOT) satellite mission. Our results demonstrate that in the Mallorca channel the horizontal dimensions of the scales that SWOT aims to resolve may be as small as 6 km. We observe that the water masses that reside at intermediate layers are increasing their temperature and salinity extrema over time. Temperature annual cycle shows an averaged temperature gradient of ∼6 °C in 6 months at the upper layer, with a disconnection with the annual cycle at 100 m. Dynamic variability at shorter temporal scales is more intense than the annual cycle. Small coherent features are observed in spring and summer, with radius ranging from 5 to 18 km. The transport of water through the channel is characterized by the inflow of recent Atlantic water and the outflow of local Atlantic water. Understanding the hydrodynamics of this region will have an important contribution to the calibration phase of the SWOT satellite mission, the next big breakthrough in Earth observation. High‐frequency variability dominates the circulation and transport across the channelThe characteristic horizontal dimension of mesoscale instabilities in this region is 6.0 kmTwo‐way flow controls the annual cycle of the transport of water with prevalence of the inflow of Atlantic water
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- 2019
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178. Mapping the nautical carrying capacity of anchoring areas of the Balearic Islands' coast.
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Gómez, Aina G., Balaguer, Pau, Fernández-Mora, Àngels, and Tintoré, Joaquín
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ENVIRONMENTAL risk ,ISLANDS ,ENVIRONMENTAL management ,COASTS - Abstract
The irregular distribution of marinas along the coast together with the natural attraction of some specific sites is leading to an over-capacity in many popular anchoring Mediterranean destinations during the summer season. This study proposes a standard procedure to assess the physical, social and environmental nautical carrying capacity of anchoring areas. Based on legislative restrictions and homogenous criteria, the anchoring sites are identified and the physical, social and environmental nautical carrying capacity is computed, thus establishing a range of distances between boats. The daily potential carrying capacity, considering the physical, social or environmental perspective, is assessed using an analysis of how suitable or safe a particular site is for anchoring. The physical, social and environmental saturation risk on the sandy seabed of each anchoring area is computed considering the relation between demand and the estimated physical, social and environmental carrying capacity, respectively. Methods have been applied to 318 anchoring areas along the coast of the Balearic Islands, confirming its usefulness as an environmental management tool. [Display omitted] • Nautical carrying capacity can be used by managers and authorities at different scales. • The physical, social and environmental nautical carrying capacity in anchoring areas is estimated. • The safety perspective is considered to estimate physical, social and environmental daily potential carrying capacity. • The physical, social and environmental saturation risk of overcrowding is assessed. • An atlas of the Balearic Islands coast with 318 anchoring areas is created. [ABSTRACT FROM AUTHOR]
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- 2023
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179. Beobachtungsstudie mit Betaferon® bei früher MS unter besonderer Berücksichtigung von CIS-Patienten (BEGIN – Betaferon Given In Newly Emerging MS)
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Bauer-Steinhusen, U, Zieger, L, Schilli, M, Tintoré, M, and Czekalla, J
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- 2024
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180. Multiple sclerosis risk perception and acceptance for Brazilian patients.
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Bichuetti, Denis Bernardi, Franco, Carolina Azze, Elias, Isaac, Mendonça, Andreia C. R., Diniz Carvalho, Lorraine Fiama, Diniz, Denise Sisterolli, Tur, Carmen, Tintoré, Mar, and de Oliveira, Enedina Maria Lobato
- Abstract
Copyright of Arquivos de Neuro-Psiquiatria is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2018
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181. Validation of the Spanish version of DYsphagia in MUltiple Sclerosis questionnaire (DYMUS).
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Renom, Marta, Galán, Ingrid, Vidal, Xavier, Aldevert, Mireia, Curto, Gemma, Feliu, Patricia, García, Itziar, Gonzalo, Lorena, Sibera, Xavier, Anglada, Elisenda, Meza, Roger, García, Montserrat, Najas, Víctor, Mongay-Ochoa, Neus, Arévalo, María Jesús, Vidal-Jordana, Ángela, Tintoré, Mar, Bascuñana, Helena, Montalban, Xavier, and Terré, Rosa
- Abstract
• DYMUS-SP has a good internal consistency and a good test-retest reliability. • DYMUS-SP detected three times more dysphagia than a dichotomous question. • DYMUS-SP can be helpful as a screening tool when combined with other measures. Dysphagia is a common symptom in multiple sclerosis that can occur even early in the disease course and can lead to serious complications. Early recognition and treatment can promote comfort, safety and optimal nutritional status. Few dysphagia rating scales are available in Spanish. The aim of this study was to translate the Dysphagia in Multiple Sclerosis Questionnaire (DYMUS) into Spanish and to validate it. Forward and backward translation method was used to translate the original English version of DYMUS into Spanish. A pilot-study with 10 PwMS was carried on in order to improve the intelligibility of the instrument, comprehensibility and content validity of the questionnaire. The questionnaire was filled out by 100 PwMS who were asked a dichotomous question on their swallowing ("Do you have swallowing troubles?"). Descriptive data are presented as median and quartiles for continuous variables and frequency and percentage for categorical ones. Internal consistency reliability was estimated by Cronbach's alfa. Test-retest reliability was estimated by intraclass correlation coefficient. Concurrent validity with a speech and language therapy assessment (SLT-A) was measured with the weighted kappa statistic for the concordance for both dysphagia type and degree categories. Confirmatory factor analysis by means of structural equation models was used to verify the two-factor (solids and liquids) structure of the DYMUS questionnaire. As the goodness of fit evaluation was poor, an additional exploratory factor analysis was carried out. Internal consistency was high. The globus sensation question and the weight loss questions (item 3 and 10) are the least specific with dysphagia symptomatology so they are worst correlated with the sum of the others (item-rest correlation, 0.243 and 0.248, respectively). The test-retest reliability of the DYMUS among 40 patients using ICC was 0.75 (95% CI 0.57 – 0.86). Concurrent validity with SLT-A was poor (weighted kappa 0.37 for dysphagia type and 0.38 for dysphagia degree). The DYMUS questionnaire detected three times more dysphagia (53% versus 17%) than the dichotomous question. Confirmatory factors analysis failed to confirm the bidimensional structure (solid and liquid items) often reported in other validation studies. The subsequent exploratory factor analysis also identified two factors, but with poor interpretability. DYMUS-SP scale is not a sufficiently useful scale to detect dysphagia in PwMS due to the poor concurrent validity and the probable overdiagnosis of the condition; however, it can be helpful as a screening tool when combined with other measures. [ABSTRACT FROM AUTHOR]
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- 2023
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182. Simultaneous CMV and infection following alemtuzumab treatment for multiple sclerosis.
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Pappolla, Agustín, Midaglia, Luciana, Rodríguez, Claudia P. Boix, Puig, Adaia Albasanz, Lung, Maiylyi, Camps, Isabel Ruiz, Castilló, Joaquín, Mulero, Patricia, Vidal-Jordana, Angela, Arrambide, Georgina, Rodriguez-Acevedo, Breogán, Sastre-Garriga, Jaume, Río, Jordi, Comabella, Manuel, Galan, Ingrid, Tintoré, Mar, Montalbán, Xavier, Boix Rodríguez, Claudia P, and Galán, Ingrid
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- 2019
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183. Antioxidant capacity of Mexican chia (Salvia hispanicaL.) protein hydrolyzates
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Chim-Chi, Yasser, Gallegos-Tintoré, Santiago, Jiménez-Martínez, Cristian, Dávila-Ortiz, Gloria, and Chel-Guerrero, Luis
- Abstract
Salvia hispanicaseeds were defatted by compression and this led to an increase in their fiber and protein contents. Consumption of this fiber improves bowel function and reduces blood glucose and cholesterol levels. Given its amino acids composition, S. hispanicadeffated flour can have an antioxidant effect, protect the body from free radicals, and prevent inflammatory diseases. For this study, S. hispanicaseeds were pressed with 22.07% of fat, 12.62% of protein, and 36.46% of fiber (d.b.). A protein concentrate was obtained from defatted flour by alkaline solubilization and acid precipitation allowing fiber separation. The concentrate had 77.26% of protein, the isolated fiber had 72.54% of protein. The concentrate was hydrolyzed with Alcalase–Flavourzyme for up to 240 min. The obtained hydrolyzates had equal degrees of hydrolysis (p < 0.05) and molecular weight of 21.99 and 34.16 kDa, corresponding to 11S globulin fractions. The antioxidant activity was measured by β-carotene discoloration, iron reducing antioxidant power and chelation (iron and copper) in hydrolyzates. The degree of hydrolysis and the first three antioxidant analyses showed comparable values (83%). Copper chelation decreased with time (values of 54–38%).
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- 2018
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184. Staying alert with polyhydramnios; an Ondine syndrome case
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Pellisé-Tintoré, Maria, Paltrinieri, Anna Lucia, Abulí, Anna, Murillo, Elena, Serrano, Ariana, and Albaigés, Gerard
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- 2023
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185. In situ observations of W from neutrally buoyant rotating floats during the Alboran OMEGA experiment and model intercomparisons
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Gascard, J.C., Tintoré, P., Vélez-Belchí, Pedro, and Haney, R.
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Centro Oceanográfico de Canarias ,Medio Marino - Published
- 1999
186. Is the ataxia of Charlevoix-Saguenay a developmental disease?
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Gazulla, José, Vela, Ana Carmen, Marín, Miguel Angel, Pablo, Luis, Santorelli, Filippo Maria, Benavente, Isabel, Modrego, Pedro, Tintoré, María, Berciano, José, Gazulla, José, Marín, Miguel Angel, Tintoré, María, and Berciano, José
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ATAXIA ,NEURODEGENERATION ,CEREBRAL atrophy ,MAGNETIC resonance imaging of the brain ,NEUROPATHY ,STEREOGRAPHS - Abstract
Abstract: The autosomal recessive spastic ataxia of Charlevoix–Saguenay (ARSACS) is considered a neurodegenerative disease caused by mutations in the SACS gene, located on chromosome 13q12.12. It is a syndrome that comprises skeletal, retinal and neurological manifestations, among which feature spasticity, cerebellar ataxia and peripheral neuropathy. Five patients with a molecular diagnosis of ARSACS underwent clinical, radiological, and ophthalmologic examinations. Every one of the identified causal mutations was novel. Spastic ataxia, peripheral neuropathy, pes cavus, and hammertoes were found in every case. T2 and T2-fluid attenuation inversion recovery-weighted MRI sequences demonstrated cerebellar atrophy and a hypointense linear striation at the pons. Tensor diffusion sequences revealed that the hypointense striation corresponded with hyperplasia of the pontocerebellar fibres, which gave place to abnormally thick middle cerebellar peduncles. Stereophotographs of the optic discs showed an increased number of retinal fibres, and ocular coherence tomography, increased thickness of the retinal nerve fibre layer. The authors suggest that the hyperplasic pontocerebellar fibres compress the pyramidal tracts at the pons since a very early stage of central nervous system development, causing spasticity, and may also cause cerebellar atrophy by means of glutamate-induced excitotoxicity. The abnormal amount of retinal fibres traversing the optic discs could have caused the detected mild peripheral visual field defects. Taken together, these facts point to a developmental cause in ARSACS, as it does not exhibit the tissue atrophy characteristic of degenerative diseases. Clinical deterioration in ARSACS seems to be mediated by phenomena (compression of the pyramidal tracts and cerebellar glutamate-mediated excitotoxicity) derived from the developmental anomalies referred to, while the neuromuscular symptoms are caused by a peripheral neuropathy with pathologic features suggestive of a similar origin. These observations should be taken into account when research about the origin of ARSACS is undertaken. [Copyright &y& Elsevier]
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- 2011
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187. Modulation of frontogenetic plankton production along a meandering jet by zonal wind forcing: An application to the Alboran Sea
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Oguz, Temel, Mourre, Baptiste, and Tintoré, Joaquin
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We present a coupled physical‐biological modeling study to elucidate the changes in ageostrophic frontal dynamics and the frontogenetic plankton production characteristics of a meandering jet under the impacts of successive westerly/easterly wind events combined with seasonal variations in the upstream transport and buoyancy flux characteristics of the jet, using a case study for the Alboran Sea (Western Mediterranean). Their nonlinear coupling is shown to result in different forms of physical and biological characteristics of the background jet structure that follows a meandering path around two anticyclonic gyres in the western and eastern basins and a cyclonic eddy in between. The westerly, downfront wind events broaden the jet, and result in stronger cross‐frontal density contrast and intensify ageostrophic cross‐frontal secondary circulation. Thus, they improve the frontogenetic plankton production with respect to the no‐wind case. They also support higher production along the northern coast in response to wind‐induced coastal upwelling and spreading of resulting nutrient‐rich, productive water by mesoscale stirring. These features weaken gradually as the jet transport reduces. In contrast, stronger and longer‐lasting easterlies during the reduced jet transport phase weaken the currents and frontal density structure, change the circular Western Alboran Gyre to an elongated form, and shift the main axis of the jet towards the southern basin. Then, frontogenesis fails to contribute to phytoplankton production that becomes limited to the eddy pumping within cyclones. Apart from the frontogenetic production, eddy pumping, mesoscale stirring, and diapycnal mixing of nutrients support intermittent and localized phytoplankton patches over the basin. The westerly (downfront) winds in the direction of the Atlantic Jet improve the frontogenetic plankton productionThe short‐term (weekly) easterly (upfront) winds introduce only a weak perturbation on the existing plankton production characteristicsThe stronger and longer‐lasting easterly (upfront) wind events may impose unfavorable conditions for plankton production along the jet
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- 2017
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188. Myasthenia gravis following alemtuzumab therapy for multiple sclerosis.
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Midaglia, Luciana, Gratacòs, Margarida, Caronna, Edoardo, Raguer, Nuria, Sastre-Garriga, Jaume, Montalban, Xavier, and Tintoré, Mar
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- 2018
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189. A toolbox for glider data processing and management.
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Troupin, C., Beltran, J.P., Heslop, E., Torner, M., Garau, B., Allen, J., Ruiz, S., and Tintoré, J.
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We present a complete set of freely available MATLAB/Octave scripts called the SOCIB Glider Toolbox ( https://github.com/socib/glider_toolbox ). This new toolbox automates glider data processing functions, including thermal lag correction, quality control and graphical outputs. While the scientific value of the glider platform has been proven, the experience for the glider data user is far from perfect or routine. Over the last 10 years, ocean gliders have evolved such that they are now considered as a core component of multi-platform observing systems and multi-disciplinary process studies; we now have a generic processing system that appropriately complements glider capability. In an ideal world, a simple connection to a glider would provide oceanographic data ready for scientific application in an intuitive, familiar format; the reality has been somewhat different. Up till now users have faced several time-consuming tasks that prevent them from directly and efficiently extracting new oceanographic knowledge from the acquired data. The SOCIB glider toolbox covers all stages of the data management process, including: metadata aggregation, raw data download, data processing, data correction and the automatic generation of data products and figures. It is designed to be operated either in real-time or in delayed mode, and to process data from two of the most widely used and commercially exploited glider platforms, Slocum gliders and SeaGliders. The SOCIB glider toolbox is ready to accelerate glider data integration and promote oceanographic discovery. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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190. The Copernicus Marine Environment Monitoring Service Ocean State Report
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von Schuckmann, Karina, Le Traon, Pierre-Yves, Alvarez-Fanjul, Enrique, Axell, Lars, Balmaseda, Magdalena, Breivik, Lars-Anders, Brewin, Robert J. W., Bricaud, Clement, Drevillon, Marie, Drillet, Yann, Dubois, Clotilde, Embury, Owen, Etienne, Hélène, Sotillo, Marcos García, Garric, Gilles, Gasparin, Florent, Gutknecht, Elodie, Guinehut, Stéphanie, Hernandez, Fabrice, Juza, Melanie, Karlson, Bengt, Korres, Gerasimos, Legeais, Jean-François, Levier, Bruno, Lien, Vidar S., Morrow, Rosemary, Notarstefano, Giulio, Parent, Laurent, Pascual, Álvaro, Pérez-Gómez, Begoña, Perruche, Coralie, Pinardi, Nadia, Pisano, Andrea, Poulain, Pierre-Marie, Pujol, Isabelle M., Raj, Roshin P., Raudsepp, Urmas, Roquet, Hervé, Samuelsen, Annette, Sathyendranath, Shubha, She, Jun, Simoncelli, Simona, Solidoro, Cosimo, Tinker, Jonathan, Tintoré, Joaquín, Viktorsson, Lena, Ablain, Michael, Almroth-Rosell, Elin, Bonaduce, Antonio, Clementi, Emanuela, Cossarini, Gianpiero, Dagneaux, Quentin, Desportes, Charles, Dye, Stephen, Fratianni, Claudia, Good, Simon, Greiner, Eric, Gourrion, Jerome, Hamon, Mathieu, Holt, Jason, Hyder, Pat, Kennedy, John, Manzano-Muñoz, Fernando, Melet, Angélique, Meyssignac, Benoit, Mulet, Sandrine, Buongiorno Nardelli, Bruno, O’Dea, Enda, Olason, Einar, Paulmier, Aurélien, Pérez-González, Irene, Reid, Rebecca, Racault, Marie-Fanny, Raitsos, Dionysios E., Ramos, Antonio, Sykes, Peter, Szekely, Tanguy, and Verbrugge, Nathalie
- Abstract
ABSTRACTThe Copernicus Marine Environment Monitoring Service (CMEMS) Ocean State Report (OSR) provides an annual report of the state of the global ocean and European regional seas for policy and decision-makers with the additional aim of increasing general public awareness about the status of, and changes in, the marine environment. The CMEMS OSR draws on expert analysis and provides a 3-D view (through reanalysis systems), a view from above (through remote-sensing data) and a direct view of the interior (through in situmeasurements) of the global ocean and the European regional seas. The report is based on the unique CMEMS monitoring capabilities of the blue (hydrography, currents), white (sea ice) and green (e.g. Chlorophyll) marine environment. This first issue of the CMEMS OSR provides guidance on Essential Variables, large-scale changes and specific events related to the physical ocean state over the period 1993–2015. Principal findings of this first CMEMS OSR show a significant increase in global and regional sea levels, thermosteric expansion, ocean heat content, sea surface temperature and Antarctic sea ice extent and conversely a decrease in Arctic sea ice extent during the 1993–2015 period. During the year 2015 exceptionally strong large-scale changes were monitored such as, for example, a strong El Niño Southern Oscillation, a high frequency of extreme storms and sea level events in specific regions in addition to areas of high sea level and harmful algae blooms. At the same time, some areas in the Arctic Ocean experienced exceptionally low sea ice extent and temperatures below average were observed in the North Atlantic Ocean.
- Published
- 2016
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191. Upstream control of the frontal jet regulating plankton production in the Alboran Sea (Western Mediterranean)
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Oguz, Temel, Mourre, Baptiste, and Tintoré, Joaquín
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Using a coupled physical‐biological model, we document that a ∼30 km wide meandering jet constitutes a major source of biological enrichment in the Alboran Sea (Western Mediterranean) even in the absence of wind forcing and tidal dynamics. The level of enrichment is shown to vary markedly during the year depending on the upstream characteristics of the jet as it exits from the Gibraltar Strait. When its intensity is sufficiently low and characterized by weaker cross‐frontal density gradients during winter‐spring, the jet is weakly nonlinear and may not fulfill the necessary conditions for frontogenesis. It then remains weakly productive. In the case of stronger jet intensity (>1.1 Sv) accompanied by stronger cross‐frontal density and velocity gradients within the Alboran Sea during summer‐autumn, the frontal jet becomes strongly nonlinear and ageostrophic with large cross‐frontal vorticity changes on the order of planetary vorticity. Under these conditions, upward vertical velocities in the range 10–50 m d−1supply nutrients into the euphotic layer more effectively and support high‐level frontogenesis‐induced phytoplankton production on the anticyclonic side of the main jet axis. The strong eddy pumping mechanism also provides a comparable level of plankton production within strongly nonlinear elongated cyclonic eddies along the outer periphery of the frontal jet. The plankton biomass is advected partially by the jet along its trajectory and dispersed within the basin by mesoscale eddies and meanders. The meandering jet constitutes a major source of biological enrichment in the Alboran SeaThe production varies seasonally depending on the intensity of the jet at the exit section of the Strait of GibraltarCross‐frontal ageostrophic circulation and eddy pumping both support the production in summer‐autumn
- Published
- 2016
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192. Subsurface circulation and mesoscale variability in the Algerian subbasin from altimeter‐derived eddy trajectories
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Escudier, Romain, Mourre, Baptiste, Juza, Mélanie, and Tintoré, Joaquín
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Algerian eddies are the strongest and largest propagating mesoscale structures in the Western Mediterranean Sea. They have a large influence on the mean circulation, water masses and biological processes. Over 20 years of satellite altimeter data have been analyzed to characterize the propagation of these eddies using automatic detection methods and cross‐correlation analysis. We found that, on average, Algerian eddy trajectories form two subbasin scale anticlockwise gyres that coincide with the two Algerian gyres which were described in the literature as the barotropic circulation in the area. This result suggests that altimetry sea surface observations can provide information on subsurface currents and their variability through the study of the propagation of deep mesoscale eddies in semienclosed seas. The analysis of eddy sea level anomalies along the mean pathways reveals three preferred areas of formation. Eddies are usually formed at a specific time of the year in these areas, with a strong interannual variability over the last 20 years. Statistical analysis of Algerian eddy pathways reveals the barotropic circulation in the regionAnalysis of altimeter data has potential information on subsurface currents and their variabilityEddy trajectories present a seasonal and interannual variability with three main areas of formation
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- 2016
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193. SOCIB operational ocean forecasting system and multi-platform validation in the Western Mediterranean Sea
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Juza, M., Mourre, B., Renault, L., Gómara, S., Sebastián, K., Lora, S., Beltran, J. P., Frontera, B., Garau, B., Troupin, C., Torner, M., Heslop, E., Casas, B., Escudier, R., Vizoso, G., and Tintoré, J.
- Abstract
ABSTRACTThis paper describes the high-resolution Western Mediterranean Sea Operational Forecasting System (WMOP) developed at the Balearic Islands Coastal Observing and Forecasting System (SOCIB). The system runs on a daily basis driven by high-resolution atmospheric forcing, providing 3-day forecasts of physical oceanic variables with a 2 km horizontal resolution, thus representing the ocean variability from mesoscale to basin scale from the Gibraltar Strait to the Sardinia Channel. A systematic regional monitoring and validation system has been developed using multi-platform observations, allowing the evaluation of both the overall realism of the predictions and the specific errors in each sub-basin.
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- 2016
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194. Forecasting the solar cycle with genetic algorithms
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Orfila, A., Ballester, J. L., Oliver, R., Alvarez, A., Tintoré, J., Orfila, A., Ballester, J. L., Oliver, R., Alvarez, A., and Tintoré, J.
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In the past, it has been postulated that the irregular dynamics of the solar cycle may embed a low order chaotic process (Weiss 1988, 1994; Spiegel 1994) which, if true, implies that the future behaviour of solar activity should be predictable. Here, starting from the historical record of Zürich sunspot numbers, we build a dynamical model of the solar cycle which allows us to make a long-term forecast of its behaviour. Firstly, the deterministic part of the time series has been reconstructed using the Singular Spectrum Analysis and then an evolutionary algorithm (Alvarez et al. 2001), based on Darwinian theories of natural selection and survival and ideally suited for non-linear time series, has been applied. Then, the predictive capability of the algorithm has been tested by comparing the behaviour of solar cycles 19–22 with forecasts made with the algorithm, obtaining results which show reasonable agreement with the known behaviour of those cycles. Next, the forecast of the future behaviour of solar cycle 23 has been performed and the results point out that the level of activity during this cycle will be somewhat smaller than in the two previous ones.
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- 2002
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195. Guía de cribado del cáncer de cuello de útero en España, 2014.
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Torné Bladé, Aureli, Pino Saladrigues, Marta del, Cusidó Gimferrer, Maite, Alameda Quitllet, Francesc, Andia Ortiz, Daniel, Castellsagué Piqué, Xavier, Cortés Bordoy, Javier, Granados Carreño, Rosario, Guarch Troyas, Rosa María, LLoveras Rubio, Belén, Lubrano Rosales, Amina, Martínez-Escoriza, Juan Carlos, Ordi Majà, Jaume, Puig-Tintoré, Luis M., Mena, Mar Ramírez, de Sanjosé Llongueras, Silvia, Torrejón Cardoso, Rafael, José, Xavier Bosch, Piris Pinilla, Miguel Ángel, and Costa, Julio Rodríguez
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- 2014
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196. Carcinoma micropapilar infiltrante de la mama. Pronóstico a largo plazo
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Castellet, Cristina, Tresserra, Francesc, Pellisé-Tintoré, María, Sánchez-Prieto, Manuel, Fábregas, Rafael, Baulies, Sonia, and Rodríguez, Ignacio
- Abstract
El carcinoma micropapilar infiltrante (CMI) es una variante histológica inusual y potencialmente agresiva caracterizada por primera vez en 1993 por Siriangkul et al. y que no formó parte de la clasificación de la Organización Mundial de la Salud (OMS) hasta 2003, como tumor mamario epitelial. Representa menos del 2% del total de carcinomas invasivos de la mama y se presupone que presenta un pronóstico desfavorable en comparación con otros carcinomas convencionales debido a su elevado tropismo vascular y linfático.
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- 2023
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197. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process
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Rovira, Àlex, Wattjes, Mike P., Tintoré, Mar, Tur, Carmen, Yousry, Tarek A., Sormani, Maria P., De Stefano, Nicola, Filippi, Massimo, Auger, Cristina, Rocca, Maria A., Barkhof, Frederik, Fazekas, Franz, Kappos, Ludwig, Polman, Chris, Miller, David, and Montalban, Xavier
- Abstract
The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over the past few years. Technical improvements and continuously emerging data from clinical trials and observational studies have contributed to the enhanced performance of this tool for achieving a prompt diagnosis in patients with MS. The aim of this article is to provide guidelines for the implementation of MRI of the brain and spinal cord in the diagnosis of patients who are suspected of having MS. These guidelines are based on an extensive review of the recent literature, as well as on the personal experience of the members of the MAGNIMS (Magnetic Resonance Imaging in MS) network. We address the indications, timing, coverage, reporting and interpretation of MRI studies in patients with suspected MS. Our recommendations are intended to help radiologists and neurologists standardize and optimize the use of MRI in clinical practice for the diagnosis of MS.
- Published
- 2015
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198. Toward an integrated HF radar network in the Mediterranean Sea to improve search and rescue and oil spill response: the TOSCA project experience
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Bellomo, L., Griffa, A., Cosoli, S., Falco, P., Gerin, R., Iermano, I., Kalampokis, A., Kokkini, Z., Lana, A., Magaldi, M.G., Mamoutos, I., Mantovani, C., Marmain, J., Potiris, E., Sayol, J.M., Barbin, Y., Berta, M., Borghini, M., Bussani, A., Corgnati, L., Dagneaux, Q., Gaggelli, J., Guterman, P., Mallarino, D., Mazzoldi, A., Molcard, A., Orfila, A., Poulain, P.-M., Quentin, C., Tintoré, J., Uttieri, M., Vetrano, A., Zambianchi, E., and Zervakis, V.
- Abstract
High-frequency (HF) coastal radars measure current velocity at the ocean surface with a 30–100 km range and 1–3 km resolution, every 0.25–1 h. HF radars are well suited to many applications, such as search and rescue (SaR), oil-spill mitigation and ecosystem management. Here we present a first organized core of 12 HF radars installed in five sites in four countries (Greece, Italy, France and Spain) within the European MED project, the Tracking Oil Spill and Coastal Awareness (TOSCA) network. Dedicated experiments tested radar capabilities to estimate transport driven by currents, which is the key feature for all the above applications. Experiments involved the deployment of drifters, i.e., floating buoys, acting as proxies for substances passively advected by currents. Using HF radars the search range is reduced by a factor of 1.6 to 5.3 after 24 h. The paper also underlines the importance of sharing common tools for HF radar data processing and the need to mitigate radio frequency interference. The effort can be regarded as an initial step toward the creation of a Mediterranean or European HF radar network, crucial for any European integrated ocean observing system (IOOS).
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- 2015
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199. Coastal Ocean Forecasting: system integration and evaluation
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Kourafalou, V.H., De Mey, P., Le Hénaff, M., Charria, G., Edwards, C.A., He, R., Herzfeld, M., Pascual, A., Stanev, E.V., Tintoré, J., Usui, N., van der Westhuysen, A.J., Wilkin, J., and Zhu, X.
- Abstract
Recent advances in Coastal Ocean Forecasting Systems (COFS) are discussed. Emphasis is given to the integration of the observational and modeling components, each developed in the context of monitoring and forecasting in the coastal seas. These integrated systems must be linked to larger scale systems toward seamless data sets, nowcasts and forecasts (from the global ocean, through the continental shelf and to the nearshore regions). Emerging capabilities include: methods to optimize coastal/regional observational networks; and probabilistic approaches to address both science and applications related to COFS. International collaboration is essential to exchange best practices, achieve common frameworks and establish standards.
- Published
- 2015
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200. TNFRSF1A polymorphisms rs1800693 and rs4149584 in patients with multiple sclerosis.
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Comabella, Manuel, Caminero, Ana B, Malhotra, Sunny, Agulló, Luis, Fernández, Oscar, Reverter, Ferran, Vandenbroeck, Koen, Rodríguez-Antigüedad, Alfredo, Matesanz, Fuencisla, Izquierdo, Guillermo, Urcelay, Elena, López-Larios, Arturo, Sánchez, Alex, Otero, Susana, Tintoré, Mar, and Montalban, Xavier
- Published
- 2013
- Full Text
- View/download PDF
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