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151. Deferred stent implantation in patients with ST-segment elevation myocardial infarction:a pilot study

Author

Kelbæk, Henning, Engstrøm, Thomas, Ahtarovski, Kiril A, Lønborg, Jacob, Vejlstrup, Niels, Pedersen, Frants, Holmvang, Lene, Helqvist, Steffen, Saunamäki, Kari, Jørgensen, Erik, Clemmensen, Peter, Kløvgaard, Lene, Tilsted, Hans-Henrik, Raungaard, Bent, Ravkilde, Jan, Aaroe, Jens, Eggert, Svend, Køber, Lars, Kelbæk, Henning, Engstrøm, Thomas, Ahtarovski, Kiril A, Lønborg, Jacob, Vejlstrup, Niels, Pedersen, Frants, Holmvang, Lene, Helqvist, Steffen, Saunamäki, Kari, Jørgensen, Erik, Clemmensen, Peter, Kløvgaard, Lene, Tilsted, Hans-Henrik, Raungaard, Bent, Ravkilde, Jan, Aaroe, Jens, Eggert, Svend, and Køber, Lars

Published
2013

152. Behandling af kardiogent shock med perkutan mekanisk cirkulationsstøtte

Author

Junker, Anders, Kaltoft, Anne Kjer, Hassager, Christian, Christensen, Erika Frischknecht, Lippert, Freddy, Ravn, Hanne Berg, Eiskjær, Hans, Tilsted, Hans-Henrik, Schmidt, Henrik, de Haas, Inge, Møller, Jacob Eifer, Ravkilde, Jan, Lassen, Jens Flensted, Wachtell, Kristian, Holmvang, Lene, Jensen, Lise Okkels, Greve, Matias Lindholm, Engstrøm, Thomas, Junker, Anders, Kaltoft, Anne Kjer, Hassager, Christian, Christensen, Erika Frischknecht, Lippert, Freddy, Ravn, Hanne Berg, Eiskjær, Hans, Tilsted, Hans-Henrik, Schmidt, Henrik, de Haas, Inge, Møller, Jacob Eifer, Ravkilde, Jan, Lassen, Jens Flensted, Wachtell, Kristian, Holmvang, Lene, Jensen, Lise Okkels, Greve, Matias Lindholm, and Engstrøm, Thomas

Abstract

Despite rapid revascularisation with circulatory support using inotropes and intra-aortic balloon counterpulsation, the mortality of cardiogenic shock complicating acute myocardial infarction still exceeds 50%. An alternative treatment strategy is restoration of cardiac output by using a ventricular assist device which can be inserted in the acute setting using the Impella device, a catheter-based flow pump. DanShock is a Danish multicentre study that will assess whether circulatory support using the Impella device will improve the outcome of cardiogenic shock compared to conventional management.

Published
2013

154. Clinical outcomes after treatment of multiple lesions with zotarolimus-eluting versus sirolimus-eluting coronary stents (a SORT OUT III substudy)

Author

Thim, Troels, Maeng, Michael, Lassen, Jens Flensted, Kaltoft, Anne Kjer, Jensen, Lisette Okkels, Ravkilde, Jan, Thayssen, Per, Galatius, Søren, Christiansen, Evald Høj, Engstrøm, Thomas, Madsen, Morten Vesterager, Thuesen, Leif, Tilsted, Hans Henrik, Thim, Troels, Maeng, Michael, Lassen, Jens Flensted, Kaltoft, Anne Kjer, Jensen, Lisette Okkels, Ravkilde, Jan, Thayssen, Per, Galatius, Søren, Christiansen, Evald Høj, Engstrøm, Thomas, Madsen, Morten Vesterager, Thuesen, Leif, and Tilsted, Hans Henrik

Abstract

Data on clinical outcomes among patients treated with the zotarolimus-eluting Endeavor™ stent versus the sirolimus-eluting Cypher™ stent favor the sirolimus-eluting stent. However, a separate comparison of clinical outcome among patients treated for multiple lesions with these stents is lacking. We performed this comparison within the SORT OUT III trial data set.

Published
2012

155. Factors associated with failure to identify the culprit artery by the electrocardiogram in inferior ST-elevation myocardial infarction

Author

Tahvanainen, Minna, Nikus, Kjell C, Holmvang, Lene, Clemmensen, Peter, Sclarovsky, Samuel, Birnbaum, Yochai, Kelbæk, Henning, Huhtala, Heini, Tilsted, Hans-Henrik, Eskola, Markku J, Tahvanainen, Minna, Nikus, Kjell C, Holmvang, Lene, Clemmensen, Peter, Sclarovsky, Samuel, Birnbaum, Yochai, Kelbæk, Henning, Huhtala, Heini, Tilsted, Hans-Henrik, and Eskola, Markku J

Abstract

Right and left circumflex coronary artery occlusions cause inferior myocardial infarction. To improve the targeting of diagnostic and therapeutic measures individually, factors interfering with identification of the culprit artery by the electrocardiogram (ECG) were explored.

Published
2011

156. No gender differences in prognosis and preventive treatment in patients with AMI without significant stenoses

Author

Hansen, Kim, Hvelplund, Anders, Abildstrøm, Steen Zabell, Prescott, Eva, Madsen, Mette, Madsen, Jan Kyst, Jensen, Jan Skov, Thuesen, Leif, Thayssen, Per, Tilsted, Hans Henrik, Jørgensen, Erik, Galatius, Søren, Hansen, Kim, Hvelplund, Anders, Abildstrøm, Steen Zabell, Prescott, Eva, Madsen, Mette, Madsen, Jan Kyst, Jensen, Jan Skov, Thuesen, Leif, Thayssen, Per, Tilsted, Hans Henrik, Jørgensen, Erik, and Galatius, Søren

Abstract

Objective: To investigate possible gender differences in patients with acute myocardial infarction (AMI) and without significant stenoses on coronary angiography (CAG) regarding prognosis and use of secondary preventive medication. Design: Nationwide register-based cohort study. Patients: By compiling data from Danish registries, we identified 20,800 patients hospitalized with AMI during 2005-2007. We included the 834 women and 761 men without significant stenoses on CAG who were discharged and alive after 60 days. Main outcome measures: All-cause mortality, recurrent AMI, and redeeming a prescription for a lipid-lowering drug, beta-blocker, clopidogrel, or aspirin within 60 days of discharge. Results: During follow-up, 97 women and 60 men died, resulting in a crude female/male hazard ratio (HR) of 1.51 (95% CI 1.09-2.08). After adjustment for age, time-period, and comorbidity, the gender difference was attenuated (HR 1.22, 95% CI 0.86-1.72). AMI recurrence was experienced by 28 women and 29 men with a female/male HR 0.88 (95% CI 0.52-1.48). After multivariable adjustment results were similar (HR 0.84, 95% CI 0.50-1.43). More women than men redeemed a prescription for lipid-lowering drugs with no differences in other medication. In the adjusted models lipid-lowering drugs, beta-blockers, clopidogrel, and aspirin were all redeemed equally with odds ratio (OR) 1.25 (95% CI 0.99-1.59), OR 1.10 (95% CI 0.88-1.37), OR 1.09 (95% CI 0.88-1.34), and OR 1.13 (95% CI 0.90-1.42), respectively. Conclusion: Our study shows that in a population of patients with a first admission for AMI and no significant stenoses on CAG, women share the same prospects as men regarding long-term prognosis and the extent of secondary preventive medical treatment.

Published
2011

157. Value of the 12-lead electrocardiogram to define the level of obstruction in acute anterior wall myocardial infarction: correlation to coronary angiography and clinical outcome in the DANAMI-2 trial

Author

Eskola, Markku J, Nikus, Kjell C, Holmvang, Lene, Sclarovsky, Samuel, Tilsted, Hans-Henrik, Huhtala, Heini, Niemelä, Kari O, Clemmensen, Peter, Eskola, Markku J, Nikus, Kjell C, Holmvang, Lene, Sclarovsky, Samuel, Tilsted, Hans-Henrik, Huhtala, Heini, Niemelä, Kari O, and Clemmensen, Peter

Abstract

Udgivelsesdato: 2009-Jan-24, BACKGROUND: Acute anterior myocardial infarction (MI) caused by proximal occlusion of the left anterior descending coronary artery (LAD), is associated with unfavourable outcome and should be recognized by simple noninvasive methods like the 12-lead electrocardiogram (ECG). METHODS: In a prospective post-hoc DANAMI-2 substudy we compared two pre-specified ECG patterns to determine the level of LAD occlusion. The ECG findings were correlated to coronary angiography from the acute phase. The impact on clinical outcome of ECG and angiographic signs of proximal versus distal LAD occlusion was studied. RESULTS: In 146 patients without confounding factors on the ECG, either ST-elevation>or=0.5 mm in lead aVL or any ST-elevation in lead aVR in association with precordial ST-segment elevation in at least two contiguous leads (including V2, V3 or V4) had a sensitivity of 94%, specificity of 49%, positive predictive value of 85% and negative predictive value of 71% to predict a proximal LAD lesion. Surprisingly, ECG or angiographic signs of lesion proximality were not associated with worse outcome at 30 day or 2.7 year follow-up. CONCLUSIONS: The site of occlusion in the LAD could be reliably predicted by 12-lead ECG in patients with acute anterior MI. The prognostic significance of the level of occlusion in the LAD in the modern era of acute ST-elevation MI treatment should be reassessed.

Published
2008

158. TCT-194 5-Year Outcome Of Zotarolimus-Eluting Versus Sirolimus-Eluting Coronary Stent Implantation In Patients With And Without Diabetes Mellitus

Author

Maeng, Michael, primary, Christiansen, Evald H., additional, Jensen, Lisette Okkels, additional, Kaltoft, Anne, additional, Madsen, Morten, additional, Ravkilde, Jan, additional, Soerensen, Henrik T., additional, Thayssen, Per, additional, Thuesen, Leif, additional, Tilsted, Hans-Henrik, additional, and Lassen, Jens F., additional

Published
2013
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159. TCT-12 Short Versus Long-Term Clinical Outcomes In A Randomised Comparison Of Zotarolimus- and Sirolimus-Eluting Coronary Stents

Author

Maeng, Michael, primary, Tilsted, Hans-Henrik, additional, Jensen, Lisette Okkels, additional, Christiansen, Evald H., additional, Krusell, Lars, additional, Jensen, Jan S., additional, Aarøe, Jens, additional, Boetker, Hans Erik, additional, Kaltoft, Anne, additional, Kelbaek, Henning, additional, Kristensen, Steen D., additional, Thuesen, Leif, additional, Madsen, Morten, additional, Soerensen, Henrik T., additional, Villadsen, Anton, additional, Thayssen, Per, additional, Ravkilde, Jan, additional, and Lassen, Jens F., additional

Published
2013
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160. TCT-598 Mechanisms of Incomplete Stent Apposition After Implantation of Drug-eluting Stents in patients with ST-segment Elevation Myocardial Infarction

Author

Antonsen, Lisbeth, primary, Christiansen, Evald H., additional, Maeng, Michael, additional, Kaltoft, Anne, additional, Thayssen, Per, additional, Tilsted, Hans-Henrik, additional, Thuesen, Leif, additional, Ravkilde, Jan, additional, Krusell, Lars, additional, Hougaard, Mikkel, additional, Lassen, Jens F., additional, and Jensen, Lisette Okkels, additional

Published
2013
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161. LONG–TERM OUTCOME AFTER REVASCULARIZATION WITH EVEROLIMUS– AND SIROLIMUS–ELUTING STENTS IN PATIENTS WITH RENAL INSUFFICIENCY: FROM THE SORT OUT IV TRIAL

Author

Okkels Jensen, Lisette, primary, Thayssen, Per, additional, Kaltoft, Anne, additional, Tilsted, Hans–Henrik, additional, Maeng, Michael, additional, Christiansen, Evald, additional, Hansen, Knud, additional, Villadsen, Anton Boel, additional, Krusell, Lars, additional, Junker, Anders, additional, Madsen, Morten, additional, Ravkilde, Jan, additional, Thuesen, Leif, additional, and Lassen, Jens, additional

Published
2013
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162. RISK FOR PERSISTENT RENAL DYSFUNCTION IN PATIENTS WITH CONTRAST–INDUCED NEPHROPATHY AFTER PRIMARY PCI

Author

Thayssen, Per, primary, Hansen, Henrik Steen, additional, Kaltoft, Anne, additional, Ravkilde, Jan, additional, Hansen, Knud Noerregaard, additional, Bøtker, Hans Erik, additional, Tilsted, Hans–Henrik, additional, Junker, Anders, additional, Thuesen, Leif, additional, Veien, Karsten T., additional, and Jensen, Lisette Okkels, additional

Published
2013
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164. VERY LATE STENT THROMBOSIS AFTER REVASCULARIZATION WITH EVEROLIMUS AND SIROLIMUS–ELUTING STENTS: FROM THE SORT OUT IV TRIAL

Author

Okkels Jensen, Lisette, primary, Thayssen, Per, additional, Tilsted, Hans–Henrik, additional, Maeng, Michael, additional, Kaltoft, Anne, additional, Christiansen, Evald, additional, Hansen, Knud, additional, Madsen, Morten, additional, Ravkilde, Jan, additional, Thuesen, Leif, additional, and Lassen, Jens, additional

Published
2013
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165. Deferred stent implantation in patients with ST-segment elevation myocardial infarction: a pilot study

Author

Kelbæk, Henning, primary, Engstrøm, Thomas, additional, Ahtarovski, Kiril A., additional, Lønborg, Jacob, additional, Vejlstrup, Niels, additional, Pedersen, Frants, additional, Holmvang, Lene, additional, Helqvist, Steffen, additional, Saunamäki, Kari, additional, Jørgensen, Erik, additional, Clemmensen, Peter, additional, Kløvgaard, Lene, additional, Tilsted, Hans-Henrik, additional, Raungaard, Bent, additional, Ravkilde, Jan, additional, Aaroe, Jens, additional, Eggert, Svend, additional, and Køber, Lars, additional

Published
2013
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166. Biolimus-eluting biodegradable polymer-coated stent versus durable polymer-coated sirolimus-eluting stent in unselected patients receiving percutaneous coronary intervention (SORT OUT V): a randomised non-inferiority trial

Author

Christiansen, Evald Høj, primary, Jensen, Lisette Okkels, additional, Thayssen, Per, additional, Tilsted, Hans-Henrik, additional, Krusell, Lars Romer, additional, Hansen, Knud Nørregaard, additional, Kaltoft, Anne, additional, Maeng, Michael, additional, Kristensen, Steen Dalby, additional, Bøtker, Hans Erik, additional, Terkelsen, Christian Juhl, additional, Villadsen, Anton Boel, additional, Ravkilde, Jan, additional, Aarøe, Jens, additional, Madsen, Morten, additional, Thuesen, Leif, additional, and Lassen, Jens Flensted, additional

Published
2013
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167. Incidence of definite stent thrombosis or in-stent restenosis after drug-eluting stent implantation for treatment of coronary in-stent restenosis: From Western Denmark heart registry

Author

Jensen, Jesper Khedri, primary, Jensen, Lisette Okkels, additional, Terkelsen, Christian Juhl, additional, Lassen, Jens Flensted, additional, Tilsted, Hans Henrik, additional, Hansen, Knud Noerregaard, additional, Maeng, Michael, additional, Thuesen, Leif, additional, and Thayssen, Per, additional

Published
2012
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168. TCT-55 Major Adverse Cardiac Events Associated With Discontinuation Of Clopidogrel Treatment Within The First Year After Coronary Stent Implantation In Western Denmark

Author

Maeng, Michael, primary, Thim, Troels, additional, Chisholm, Gro, additional, Johansen, Martin, additional, Schmidt, Morten, additional, Sørensen, Henrik T., additional, Jensen, Lisette Okkels, additional, Thayssen, Per, additional, Tilsted, Hans-Henrik, additional, Bøtker, Hans Erik, additional, Lassen, Jens, additional, and Thuesen, Leif, additional

Published
2012
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169. TCT-355 Coronary Stents In Patients With Diabetes Mellitus: The Diabetes And Drug-Eluting Stent (DiabeDES IV) Randomized Angiography Trial

Author

Maeng, Michael, primary, Baranauskas, Arvydas, additional, Thuesen, Leif, additional, Lassen, Jens Flensted, additional, Bøtker, Hans Erik, additional, Krusell, Lars, additional, Ravkilde, Jan, additional, Tilsted, Hans-Henrik, additional, Junker, Anders, additional, Thayssen, Per, additional, and Jensen, Lisette Okkels, additional

Published
2012
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170. TCT-347 Clinical Outcome Of Biolimus-Eluting Versus Sirolimus-Eluting Coronary Stent Implantation In Patients With And Without Diabetes Mellitus: A SORT OUT V Substudy

Author

Maeng, Michael, primary, Christiansen, Evald, additional, Tilsted, Hans-Henrik, additional, Ravkilde, Jan, additional, Thayssen, Per, additional, Jensen, Lisette, additional, Madsen, Morten, additional, Krusell, Lars, additional, Bøtker, Hans Erik, additional, Thuesen, Leif, additional, and Lassen, Jens Flensted, additional

Published
2012
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171. 2-Year Patient-Related Versus Stent-Related Outcomes

Author

Jensen, Lisette Okkels, primary, Thayssen, Per, additional, Christiansen, Evald Høj, additional, Tilsted, Hans Henrik, additional, Maeng, Michael, additional, Hansen, Knud Nørregaard, additional, Kaltoft, Anne, additional, Hansen, Henrik Steen, additional, Bøtker, Hans Erik, additional, Krusell, Lars Romer, additional, Ravkilde, Jan, additional, Madsen, Morten, additional, Thuesen, Leif, additional, and Lassen, Jens Flensted, additional

Published
2012
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172. Culprit only or multivessel percutaneous coronary interventions in patients with ST-segment elevation myocardial infarction and multivessel disease

Author

Jensen, Lisette, primary, Thayssen, Per, additional, Farkas, Dóra, additional, Hougaard, Mikkel, additional, Terkelsen, Christian, additional, Tilsted, Hans-Henrik, additional, Maeng, Michael, additional, Junker, Anders, additional, Lassen, Jens Flensted, additional, Horváth-Puhó, Erzsébet, additional, Sørensen, Henrik Toft, additional, and Thuesen, Leif, additional

Published
2012
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173. Clinical outcomes after treatment of multiple lesions with zotarolimus-eluting versus sirolimus-eluting coronary stents (a SORT OUT III substudy)

Author

Thim, Troels, primary, Maeng, Michael, additional, Lassen, Jens Flensted, additional, Kaltoft, Anne, additional, Jensen, Lisette Okkels, additional, Ravkilde, Jan, additional, Thayssen, Per, additional, Galatius, Søren, additional, Christiansen, Evald Høj, additional, Engstrøm, Thomas, additional, Madsen, Morten, additional, Thuesen, Leif, additional, and Tilsted, Hans Henrik, additional

Published
2012
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174. IMPACT OF LESION LENGTH ON OUTCOMES AFTER REVASCULARIZATION WITH EVEROLIMUS AND SIROLIMUS ELUTING STENTS. A SUBSTUDY OF THE SORT OUT IV TRIAL

Author

Hougaard, Mikkel, primary, Jensen, Lisette Okkels, additional, Thayssen, Per, additional, Kaltoft, Anne, additional, Tilsted, Hans-Henrik, additional, Maeng, Michael, additional, Christiansen, Evald Høj, additional, Ravkilde, Jan, additional, Madsen, Morten, additional, Junker, Anders, additional, Thuesen, Leif, additional, and Lassen, Jens, additional

Published
2012
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176. DEFINITE AND PROBABLE STENT THROMBOSIS AFTER REVASCULARIZATION WITH EVEROLIMUS- AND SIROLIMUS-ELUTING STENTS. FROM THE SORT OUT IV TRIAL

Author

Jensen, Lisette Okkels, primary, Thayssen, Per, additional, Maeng, Michael, additional, Tilsted, Hans-Henrik, additional, Kaltoft, Anne, additional, Hansen, Knud, additional, Christiansen, Evald, additional, Junker, Anders, additional, Ravkilde, Jan, additional, Thuesen, Leif, additional, and Lassen, Jens, additional

Published
2012
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178. OUTCOMES AFTER REVASCULARIZATION WITH EVEROLIMUS AND SIROLIMUS ELUTING STENTS IN PATIENTS WITH SMALL AND LARGE CORONARY ARTERIES. A SUBSTUDY OF THE SORT OUT IV TRIAL

Author

Antonsen, Lisbeth, primary, Jensen, Lisette Okkels, additional, Thayssen, Per, additional, Christiansen, Evald Høj, additional, Maeng, Michael, additional, Tilsted, Hans-Henrik, additional, Ravkilde, Jan, additional, Kaltoft, Anne, additional, Hansen, Henrik, additional, Madsen, Morten, additional, Thuesen, Leif, additional, and Lassen, Jens, additional

Published
2012
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181. Long-Term Outcome After Drug-Eluting Versus Bare-Metal Stent Implantation in Patients With ST-Segment Elevation Myocardial Infarction

Author

Kaltoft, Anne, primary, Kelbæk, Henning, additional, Thuesen, Leif, additional, Lassen, Jens Flensted, additional, Clemmensen, Peter, additional, Kløvgaard, Lene, additional, Engstrøm, Thomas, additional, Bøtker, Hans E., additional, Saunamäki, Kari, additional, Krusell, Lars R., additional, Jørgensen, Erik, additional, Tilsted, Hans-Henrik, additional, Christiansen, Evald H., additional, Ravkilde, Jan, additional, Køber, Lars, additional, Kofoed, Klaus F., additional, Terkelsen, Christian J., additional, and Helqvist, Steffen, additional

Published
2010
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182. Review of Registry and Randomised Comparisons of Zotarolimus-eluting and Sirolimus-eluting Coronary Stents in Western Denmark

Author

Maeng, Michael, primary, Kaltoft, Anne, additional, Tilsted, Hans-Henrik, additional, Ravkilde, Jan, additional, Jensen, Lisette, additional, Thayssen, Per, additional, Holm, Niels R, additional, Christiansen, Evald H, additional, Krusell, Lars R, additional, Terkelsen, Christian J, additional, Kristensen, Steen D, additional, Bøtker, Hans E, additional, Lassen, Jens F, additional, and Thuesen, Leif, additional

Published
2010
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183. Efficacy and safety of zotarolimus-eluting and sirolimus-eluting coronary stents in routine clinical care (SORT OUT III): a randomised controlled superiority trial

Author

Rasmussen, Klaus, primary, Maeng, Michael, additional, Kaltoft, Anne, additional, Thayssen, Per, additional, Kelbæk, Henning, additional, Tilsted, Hans Henrik, additional, Abildgaard, Ulrik, additional, Christiansen, Evald Høj, additional, Engstrøm, Thomas, additional, Krusell, Lars Romer, additional, Ravkilde, Jan, additional, Hansen, Peter Riis, additional, Hansen, Knud Nørregaard, additional, Abildstrøm, Steen Zabell, additional, Aarøe, Jens, additional, Jensen, Jan Skov, additional, Kristensen, Steen Dalby, additional, Bøtker, Hans Erik, additional, Madsen, Morten, additional, Johnsen, Søren Paaske, additional, Jensen, Lisette Okkels, additional, Sørensen, Henrik Toft, additional, Thuesen, Leif, additional, and Lassen, Jens Flensted, additional

Published
2010
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184. CLINICAL PRESENTATION OF IN-STENT RESTENOSIS AND ANGIOGRAPHIC CONFIRMED STENT THROMBOSIS IN PATIENTS TREATED WITH BARE METAL OR DRUG-ELUTING STENTS. FROM WESTERN DENMARK HEART REGISTRY

Author

Thayssen, Per, primary, Jensen, Lisette Okkels, additional, Kaltoft, Anne, additional, Tilsted, Hans Henrik, additional, Maeng, Michael, additional, Christiansen, Evald Hoej, additional, Hansen, Knud N., additional, Ravkilde, Jan, additional, Krusell, Lars, additional, Lassen, Jens F., additional, and Thuesen, Leif, additional

Published
2010
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185. Outcome in high risk patients with unprotected left main coronary artery stenosis treated with percutaneous coronary intervention

Author

Jensen, Lisette Okkels, primary, Kaltoft, Anne, additional, Thayssen, Per, additional, Tilsted, Hans Henrik, additional, Christiansen, Evald Hoej, additional, Mikkelsen, Kirsten Vilain, additional, Maeng, Michael, additional, Hansen, Knud Noerregaard, additional, Villadsen, Anton Boel, additional, Madsen, Morten, additional, Lassen, Jens Flensted, additional, Pedersen, Knud Erik, additional, and Thuesen, Leif, additional

Published
2009
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186. 2-Year Clinical Outcomes After Implantation of Sirolimus-Eluting, Paclitaxel-Eluting, and Bare-Metal Coronary Stents

Author

Kaltoft, Anne, primary, Jensen, Lisette Okkels, additional, Maeng, Michael, additional, Tilsted, Hans Henrik, additional, Thayssen, Per, additional, Bøttcher, Morten, additional, Lassen, Jens Flensted, additional, Krusell, Lars Romer, additional, Rasmussen, Klaus, additional, Hansen, Knud Nørregaard, additional, Pedersen, Lars, additional, Johnsen, Søren Paaske, additional, Sørensen, Henrik Toft, additional, and Thuesen, Leif, additional

Published
2009
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188. Clinical Outcome After Primary Percutaneous Coronary Intervention With Drug-Eluting and Bare Metal Stents in Patients With ST-Segment Elevation Myocardial Infarction

Author

Jensen, Lisette Okkels, primary, Maeng, Michael, additional, Thayssen, Per, additional, Kaltoft, Anne, additional, Tilsted, Hans Henrik, additional, B�ttcher, Morten, additional, Lassen, Jens Flensted, additional, Hansen, Knud N�rregaard, additional, Krusell, Lars Romer, additional, Rasmussen, Klaus, additional, Pedersen, Knud Erik, additional, Pedersen, Lars, additional, Paaske Johnsen, S�ren, additional, S�rensen, Henrik Toft, additional, and Thuesen, Leif, additional

Published
2008
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190. Influence of multivessel disease with or without additional revascularization on mortality in patients with ST-segment elevation myocardial infarction.

Author

Jensen, Lisette Okkels, Terkelsen, Christian Juhl, Horváth-Puhó, Erzsébet, Tilsted, Hans-Henrik, Maeng, Michael, Junker, Anders, Lassen, Jens Flensted, Thuesen, Leif, Sørensen, Henrik Toft, and Thayssen, Per

Abstract

Background In patients with ST-segment elevation myocardial infarction (STEMI), timely reperfusion with primary percutaneous coronary intervention (PCI) is the preferred treatment. In primary PCI patients with multivessel disease, it is unclear whether culprit vessel PCI only is the preferred treatment. We compared mortality among (1) STEMI patients with single-vessel disease and those with multivessel disease and (2) multivessel disease patients with and without additional revascularization of nonculprit lesions within 2 months after the index PCI. Methods From January 2002 to June 2009, all patients presenting with STEMI and treated with primary PCI were identified from the Western Denmark Heart Registry, which covers a population of 3.0 million. The hazard ratio (HR) for death was estimated using a Cox regression model, controlling for potential confounding. Results The study cohort consisted of 8,822 patients: 4,770 (54.1%) had single-vessel disease and 4,052 (45.9%) had multivessel disease. Overall, 1-year cumulative mortality was 7.6%, and 7-year cumulative mortality was 24.0%. Multivessel disease was associated with higher 7-year mortality (adjusted HR 1.45 [95% CI 1.30-1.62], P < .001). Among patients with multivessel disease, lack of additional revascularization beyond the culprit lesion was associated with higher 7-year mortality (adjusted HR 1.50 [95% CI 1.25-1.80], P < .001). In patients with multivessel disease who underwent additional revascularization, 7-year mortality (adjusted HR 1.01 [95% CI 0.84-1.22], P = .89) was similar compared to patients with single-vessel disease. Conclusion In STEMI patients, multivessel disease was associated with a higher mortality compared to single-vessel disease. In multivessel disease patients, additional revascularization was associated with a higher survival compared with culprit vessel PCI only. [ABSTRACT FROM AUTHOR]

Published
2015
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192. The Western Denmark Cardiac Computed Tomography Registry: a review and validation study.

Author

Nielsen, Lene Hüche, Nørgaard, Bjarne Linde, Tilsted, Hans Henrik, Sand, Niels Peter, Jensen, Jesper Møller, Bøttcher, Morten, Diederichsen, Axel C., Lambrechtsen, Jess, Kristensen, Lone Deibjerg, Mickley, Hans, Munkholm, Henrik, Gøtzsche, Ole, Knudsen, Lars Lyhne, Bøtker, Hans Erik, Pedersen, Lars, and Schmidt, Morten

Subjects
COMPUTED tomography, CARDIAC arrest, ANGIOGRAPHY, MEDICAL records, EPIDEMIOLOGY
Abstract

Background: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark. Objective: We examined the content, data quality, and research potential of the WDHR-CCTR. Methods: We retrieved 2008-2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient Registry as reference; 3) completeness of variable registration comparing observed vs expected numbers; and 4) positive predictive values as well as negative predictive values of 19 main patient and procedure variables. Results: By December 31, 2012, almost 22,000 cardiac CTs with up to 40 variables for each procedure have been registered. Of these, 87% were coronary CT angiography performed in patients with symptoms indicative of coronary artery disease. Compared with the Danish National Patient Registry, the overall procedure completeness was 72%. However, an additional medical record review of 282 patients registered in the Danish National Patient Registry, but not in the WDHR-CCTR, showed that coronary CT angiographies accounted for only 23% of all nonregistered cardiac CTs, indicating .90% completeness of coronary CT angiographies in the WDHR-CCTR. The completeness of individual variables varied substantially (range: 0%-100%), but was .85% for more than 70% of all variables. Using medical record review of 250 randomly selected patients as reference standard, the positive predictive value for the 19 variables ranged from 89% to 100% (overall 97%), whereas the negative predictive value ranged from 97% to 100% (overall 99%). Stratification by center status showed consistently high positive and negative predictive values for both university (96%/99%) and nonuniversity centers (97%/99%). Conclusion: WDHR-CCTR provides ongoing prospective registration of all cardiac CTs performed in Western Denmark since 2008. Overall, the registry data have a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research. [ABSTRACT FROM AUTHOR]

Published
2015
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194. Deferred versus conventional stent implantation in patients with ST-segment elevation myocardial infarction (DANAMI 3-DEFER): an open-label, randomised controlled trial

Author

Kelbæk, Henning, Høfsten, Dan Eik, Køber, Lars, Helqvist, Steffen, Kløvgaard, Lene, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, De Backer, Ole, Bang, Lia E, Kofoed, Klaus F, Lønborg, Jacob, Ahtarovski, Kiril, Vejlstrup, Niels, Bøtker, Hans E, Terkelsen, Christian J, Christiansen, Evald H, Ravkilde, Jan, Tilsted, Hans-Henrik, Villadsen, Anton B, Aarøe, Jens, Jensen, Svend E, Raungaard, Bent, Jensen, Lisette O, Clemmensen, Peter, Grande, Peer, Madsen, Jan K, Torp-Pedersen, Christian, and Engstrøm, Thomas

Abstract

Despite successful treatment of the culprit artery lesion by primary percutaneous coronary intervention (PCI) with stent implantation, thrombotic embolisation occurs in some cases, which impairs the prognosis of patients with ST-segment elevation myocardial infarction (STEMI). We aimed to assess the clinical outcomes of deferred stent implantation versus standard PCI in patients with STEMI.

Published
2016
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195. Three-Year Outcomes After Revascularization With Everolimus- and Sirolimus-Eluting Stents From the SORT OUT IV Trial.

Author

Jensen, Lisette Okkels, Thayssen, Per, Maeng, Michael, Christiansen, Evald Høj, Ravkilde, Jan, Hansen, Knud Nørregaard, Kaltoft, Anne, Tilsted, Hans Henrik, Madsen, Morten, and Lassen, Jens Flensted

Abstract

Objectives The study sought to compare the risk of late outcome with a focus on very late definite stent thrombosis of the everolimus-eluting stent (EES) with that of the sirolimus-eluting stent (SES) at 3-year follow-up. Background In the SORT OUT IV (SORT OUT IV Trial), comparing the EES with the SES in patients with coronary artery disease, the EES was noninferior to the SES at 9 months. The SORT OUT IV trial provides long-term head-to-head randomized comparison of the EES with the SES. Methods We prospectively randomized 2,774 patients in the SORT OUT IV trial. Follow-up through 3 years was complete in 2,771 patients (99.9%). The 3-year pre-specified endpoints were composites of safety and efficacy (major adverse cardiac events [MACE]: cardiac death, myocardial infarction, target vessel revascularization, and definite stent thrombosis). Results At 3 years, the composite endpoint MACE occurred in 9.8% of the EES group and in 11.1% of the SES group (hazard ratio [HR]: 0.89, 95% confidence interval [CI]: 0.70 to 1.12). Overall rate of definite stent thrombosis was lower in the EES group (0.2% vs. 1.4%; HR: 0.15, 95% CI: 0.04 to 0.50), which was largely attributable to a lower risk of very late definite stent thrombosis: 0.1% versus 0.8% (HR: 0.09, 95% CI: 0.01 to 0.70). Conclusions At 3-year follow-up, the MACE rate did not differ significantly between EES- and SES-treated patients. A significant reduction of overall and very late definite stent thrombosis was found in the EES group. (The SORT OUT IV TRIAL [SORT OUT IV]; NCT00552877). [ABSTRACT FROM AUTHOR]

Published
2014
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196. Differential clinical outcomes after 1 year versus 5 years in a randomised comparison of zotarolimus-eluting and sirolimus-eluting coronary stents (the SORT OUT III study): a multicentre, open-label, randomised superiority trial.

Author

Maeng, Michael, Tilsted, Hans Henrik, Jensen, Lisette Okkels, Krusell, Lars Romer, Kaltoft, Anne, Kelbæk, Henning, Villadsen, Anton B., Ravkilde, Jan, Hansen, Knuud Nørregaard, Christiansen, Evald Høj, Jensen, Jan Skov, Kristensen, Steen Dalby, Bøtker, Hans Erik, Thuesen, Leif, Madsen, Marten, Thayssen, Per, Sørensen, Henrik Toft, Lassen, Jens Flensted, and Aarøe, Jens

Subjects
*DRUG-eluting stents, *SURGICAL stents, *RAPAMYCIN, *THERAPEUTICS, *HEART diseases, *CLINICAL trials
Abstract

Background In head-to-head comparisons of coronary drug-eluting stents, the primary endpoint is traditionally assessed after 9--12 months. However, the optimum timepoint for this assessment remains unclear. In this study, we assessed clinical outcomes at up to 5 years' follow-up in patients who received two different types of drug-eluting stents. Methods We undertook this multicentre, open-label, randomised superiority trial at five percutaneous coronary intervention centres in Denmark. We randomly allocated 2332 eligible adult patients (≥18 years of age) with an indication for drug-eluting stent implantation to the zotarolimus-eluting Endeavor Sprint stent (Medtronic, Santa Rosa, CA, USA) or the sirolimus-eluting Cypher Select Plus stent (Cordis, Johnson & Johnson, Warren, NJ, USA). Randomisation of participants was achieved by computer-generated block randomisation and a telephone allocation service. The primary endpoint of the SORT OUT III study was a composite of major adverse cardiac events—cardiac death, myocardial infarction, and target vessel revascularisation--at 9 months' follow-up. In this study, endpoints included the occurrence of major adverse cardiac events and definite stent thrombosis at follow-up times of up to 5 years. Analysis was by intention to treat. The trial is registered with ClinicalTrials.gov, number NCT00660478. Findings We randomly allocated 1162 patients to receive the zotarolimus-eluting stent and 1170 to the sirolimus-eluting stent. At 5-year follow-up, rates of major adverse cardiac events were similar in patients treated with both types of stents (zotarolimus-eluting stents 197/1162 [17·0%] vs sirolimus-eluting stents 182/1170 [15·6%]; odds ratio [OR] 1·10, 95% CI 0·88--1·37; p=0·40). This finding was indicative of the directly contrasting results for rates of major adverse cardiac events at 1-year follow up (zotarolimus 93/1162 [8·0%] vs sirolimus 46/1170 [3·9%]; OR 2·13, 95% CI 1·48--3·07; p<0·0001) compared with those at follow-up between 1 and 5 years (104 [9·0%] vs 136 [11·6%]; OR 0·78, 95% CI 0·59--1·02; p=0·071). At 1-year follow-up, definite stent thrombosis was more frequent after implantation of the zotarolimus-eluting stent (13/1162 [1·1%]) than the sirolimus-eluting stent (4/1170 [0·3%]; OR 3·34, 95% CI 1·08--10·3; p=0·036), whereas the opposite finding was recorded for between 1 and 5 years' follow-up (zotarolimus-eluting stent 1/1162 [0·1%] vs sirolimus-eluting stent 21/1170 [1·8%], OR 0·05, 95% CI 0·01--0·36; p=0·003). 26 of 88 (30%) target lesion revascularisations in the zotarolimus-eluting stent group occurred between 1 and 5 years' follow-up, whereas 54 of 70 (77%) of those in the sirolimus-eluting stent group occurred during this follow-up period. Interpretation The superiority of sirolimus-eluting stents compared with zotarolimus-eluting stents at 1-year follow-up was lost after 5 years. The traditional 1-year primary endpoint assessment therefore might be insufficient to predict 5-year clinical outcomes in patients treated with coronary drug-eluting stent implantation. Funding Cordis and Medtronic. [ABSTRACT FROM AUTHOR]

Published
2014
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198. Complete revascularisation versus treatment of the culprit lesion only in patients with ST-segment elevation myocardial infarction and multivessel disease (DANAMI-3—PRIMULTI): an open-label, randomised controlled trial

Author

Engstrøm, Thomas, Kelbæk, Henning, Helqvist, Steffen, Høfsten, Dan Eik, Kløvgaard, Lene, Holmvang, Lene, Jørgensen, Erik, Pedersen, Frants, Saunamäki, Kari, Clemmensen, Peter, De Backer, Ole, Ravkilde, Jan, Tilsted, Hans-Henrik, Villadsen, Anton Boel, Aarøe, Jens, Jensen, Svend Eggert, Raungaard, Bent, and Køber, Lars

Abstract

Patients with acute ST-segment elevation myocardial infarction (STEMI) and multivessel coronary disease have a worse prognosis compared with individuals with single-vessel disease. We aimed to study the clinical outcome of patients with STEMI treated with fractional flow reserve (FFR)-guided complete revascularisation versus treatment of the infarct-related artery only.

Published
2015
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199. Zotarolimus-eluting durable-polymer-coated stent versus a biolimus-eluting biodegradable-polymer-coated stent in unselected patients undergoing percutaneous coronary intervention (SORT OUT VI): a randomised non-inferiority trial

Author

Raungaard, Bent, Jensen, Lisette Okkels, Tilsted, Hans-Henrik, Christiansen, Evald Høj, Maeng, Michael, Terkelsen, Christian Juhl, Krusell, Lars Romer, Kaltoft, Anne, Kristensen, Steen Dalby, Bøtker, Hans Erik, Thuesen, Leif, Aarøe, Jens, Jensen, Svend Eggert, Villadsen, Anton Boel, Thayssen, Per, Veien, Karsten Tange, Hansen, Knud Nørregaard, Junker, Anders, Madsen, Morten, Ravkilde, Jan, and Lassen, Jens Flensted

Abstract

New-generation drug-eluting coronary stents have reduced the risk of coronary events, especially in patients with complex disease or lesions. To what extent different stent platforms, polymers, and antiproliferative drugs affect outcomes, however, is unclear. We investigated the safety and efficacy of a third-generation stent by comparing a highly biocompatible durable-polymer-coated zotarolimus-eluting stent with a biodegradable-polymer-coated biolimus-eluting stent.

Published
2015
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