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1,010 results on '"Thomas, Mark G."'

151. Antimicrobial stewardship in human healthcare in Aotearoa New Zealand: urgent call for national leadership and co-ordinated efforts to preserve antimicrobial effectiveness.

Author

Gardiner, Sharon J., Duffy, Eamon J., Chambers, Stephen T., Thomas, Mark G., Addidle, Michael, Arnold, Brendan, Arroll, Bruce, Balm, Michelle N. D., Perales, Carolina Batlle, Berger, Sarah, Best, Emma, Betty, Bryan, Birch, Mark, Blackmore, Timothy K., Bloomfield, Max, Briggs, Simon, Bupha-Intr, Olivia, Burns, Andrew, Campbell, Chloë, and Chin, Paul K. L.

Published
2021

152. Disclosure of trauma and immune response to a Hepatitis B vaccination program

Author

Petrie, Keith J., Booth, Roger J., Pennebaker, James W., Davison, Kathryn P., and Thomas, Mark G.

Subjects
Hepatitis B vaccine -- Psychological aspects, Traumatism -- Research, Immunity -- Psychological aspects, Psychology and mental health
Abstract

This study investigated whether emotional expression of traumatic experiences influenced the immune response to a hepatitis B vaccination program. Forty medical students who tested negative for hepatitis B antibodies were randomly assigned to write about personal traumatic events or control topics during 4 consecutive daily sessions. The day after completion of the writing, participants were given their first hepatitis B vaccination, with booster injections at 1 and 4 months after the writing. Blood was collected before each vaccination and at a 6-month follow-up. Compared with the control group, participants in the emotional expression group showed significantly higher antibody levels against hepatitis B at the 4 and 6-month follow-up periods. Other immune changes evident immediately after writing were significantly lower numbers of circulating T helper lymphocytes and basophils in the treatment group. The finding that a writing intervention influences immune response provides further support for a link between emotional disclosure and health.

Published
1995

154. Human Origins in Southern African Palaeo-wetlands? Strong Claims from Weak Evidence

Author

Schlebusch, Carina M., primary, Loog, Liisa, additional, Groucutt, Huw S., additional, King, Turi, additional, Rutherford, Adam, additional, Barbieri, Chiara, additional, Barbujani, Guido, additional, Chikhi, Lounès, additional, Jakobsson, Mattias, additional, Eriksson, Anders, additional, Manica, Andrea, additional, Tishkoff, Sarah A., additional, Scerri, Eleanor M.L., additional, Scally, Aylwyn, additional, Brierley, Chris, additional, and Thomas, Mark G., additional

Published
2019
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155. Did our species evolve in subdivided populations across Africa, and Why does it matter?

Author

Scerri, Eleanor M.L., primary, Thomas, Mark G., additional, Manica, Andrea, additional, Gunz, Philipp, additional, Stock, Jay T., additional, Stringer, Chris, additional, Grove, Matt, additional, Groucutt, Huw S., additional, Timmermann, Axel, additional, Rightmire, G. Philip, additional, d'Errico, Francesco, additional, Tryon, Christian A., additional, Drake, Nick A., additional, Brooks, Alison S., additional, Dennell, Robin W., additional, Durbin, Richard, additional, Henn, Brenna M., additional, Lee-Thorp, Julia, additional, deMenocal, Peter, additional, Petraglia, Michael D., additional, Thompson, Jessica C., additional, Scally, Aylwyn, additional, and Chikhi, Lounes, additional

Published
2019
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156. The genetic landscape of Ethiopia: diversity, intermixing and the association with culture

Author

López, Saioa, primary, Tarekegn, Ayele, additional, Band, Gavin, additional, van Dorp, Lucy, additional, Bird, Nancy, additional, Morris, Sam, additional, Oljira, Tamiru, additional, Mekonnen, Ephrem, additional, Bekele, Endashaw, additional, Blench, Roger, additional, Thomas, Mark G., additional, Bradman, Neil, additional, and Hellenthal, Garrett, additional

Published
2019
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158. Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

Author

Fumagalli, Matteo, primary, Camus, Stephane M, additional, Diekmann, Yoan, additional, Burke, Alice, additional, Camus, Marine D, additional, Norman, Paul J, additional, Joseph, Agnel, additional, Abi-Rached, Laurent, additional, Benazzo, Andrea, additional, Rasteiro, Rita, additional, Mathieson, Iain, additional, Topf, Maya, additional, Parham, Peter, additional, Thomas, Mark G, additional, and Brodsky, Frances M, additional

Published
2019
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161. The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East

Author

Saag, Lehti, primary, Laneman, Margot, additional, Varul, Liivi, additional, Malve, Martin, additional, Valk, Heiki, additional, Razzak, Maria A., additional, Shirobokov, Ivan G., additional, Khartanovich, Valeri I., additional, Mikhaylova, Elena R., additional, Kushniarevich, Alena, additional, Scheib, Christiana Lyn, additional, Solnik, Anu, additional, Reisberg, Tuuli, additional, Parik, Jüri, additional, Saag, Lauri, additional, Metspalu, Ene, additional, Rootsi, Siiri, additional, Montinaro, Francesco, additional, Remm, Maido, additional, Mägi, Reedik, additional, D’Atanasio, Eugenia, additional, Crema, Enrico Ryunosuke, additional, Díez-del-Molino, David, additional, Thomas, Mark G., additional, Kriiska, Aivar, additional, Kivisild, Toomas, additional, Villems, Richard, additional, Lang, Valter, additional, Metspalu, Mait, additional, and Tambets, Kristiina, additional

Published
2019
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163. Author response: Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

Author

Fumagalli, Matteo, primary, Camus, Stephane M, additional, Diekmann, Yoan, additional, Burke, Alice, additional, Camus, Marine D, additional, Norman, Paul J, additional, Joseph, Agnel, additional, Abi-Rached, Laurent, additional, Benazzo, Andrea, additional, Rasteiro, Rita, additional, Mathieson, Iain, additional, Topf, Maya, additional, Parham, Peter, additional, Thomas, Mark G, additional, and Brodsky, Frances M, additional

Published
2019
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167. Origins of Old Testament priests

Author

Thomas, Mark G., Skorecki, Karl, Ben-Ami, Haim, Parfitt, Tudor, Bradman, Neil, and Goldstein, David B.

Published
1998

168. Little genetic differentiation as assessed by uniparental markers in the presence of substantial language variation in peoples of the Cross River region of Nigeria

Author

Mendell Nancy R, Zeitlyn David, Plaster Christopher A, Powell Adam, Pour Naser, Connell Bruce A, Veeramah Krishna R, Weale Michael E, Bradman Neil, and Thomas Mark G

Subjects
Evolution, QH359-425
Abstract

Abstract Background The Cross River region in Nigeria is an extremely diverse area linguistically with over 60 distinct languages still spoken today. It is also a region of great historical importance, being a) adjacent to the likely homeland from which Bantu-speaking people migrated across most of sub-Saharan Africa 3000-5000 years ago and b) the location of Calabar, one of the largest centres during the Atlantic slave trade. Over 1000 DNA samples from 24 clans representing speakers of the six most prominent languages in the region were collected and typed for Y-chromosome (SNPs and microsatellites) and mtDNA markers (Hypervariable Segment 1) in order to examine whether there has been substantial gene flow between groups speaking different languages in the region. In addition the Cross River region was analysed in the context of a larger geographical scale by comparison to bordering Igbo speaking groups as well as neighbouring Cameroon populations and more distant Ghanaian communities. Results The Cross River region was shown to be extremely homogenous for both Y-chromosome and mtDNA markers with language spoken having no noticeable effect on the genetic structure of the region, consistent with estimates of inter-language gene flow of 10% per generation based on sociological data. However the groups in the region could clearly be differentiated from others in Cameroon and Ghana (and to a lesser extent Igbo populations). Significant correlations between genetic distance and both geographic and linguistic distance were observed at this larger scale. Conclusions Previous studies have found significant correlations between genetic variation and language in Africa over large geographic distances, often across language families. However the broad sampling strategies of these datasets have limited their utility for understanding the relationship within language families. This is the first study to show that at very fine geographic/linguistic scales language differences can be maintained in the presence of substantial gene flow over an extended period of time and demonstrates the value of dense sampling strategies and having DNA of known and detailed provenance, a practice that is generally rare when investigating sub-Saharan African demographic processes using genetic data.

Published
2010
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169. A worldwide correlation of lactase persistence phenotype and genotypes

Author

Ingram Catherine JE, Jones Bryony L, Itan Yuval, Swallow Dallas M, and Thomas Mark G

Subjects
Evolution, QH359-425
Abstract

Abstract Background The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research. Lactase persistence is common in people of European ancestry as well as some African, Middle Eastern and Southern Asian groups, but is rare or absent elsewhere in the world. The recent identification of independent nucleotide changes that are strongly associated with lactase persistence in different populations worldwide has led to the possibility of genetic tests for the trait. However, it is highly unlikely that all lactase persistence-associated variants are known. Using an extensive database of lactase persistence phenotype frequencies, together with information on how those data were collected and data on the frequencies of lactase persistence variants, we present a global summary of the extent to which current genetic knowledge can explain lactase persistence phenotype frequency. Results We used surface interpolation of Old World lactase persistence genotype and phenotype frequency estimates obtained from all available literature and perform a comparison between predicted and observed trait frequencies in continuous space. By accommodating additional data on sample numbers and known false negative and false positive rates for the various lactase persistence phenotype tests (blood glucose and breath hydrogen), we also apply a Monte Carlo method to estimate the probability that known lactase persistence-associated allele frequencies can explain observed trait frequencies in different regions. Conclusion Lactase persistence genotype data is currently insufficient to explain lactase persistence phenotype frequency in much of western and southern Africa, southeastern Europe, the Middle East and parts of central and southern Asia. We suggest that further studies of genetic variation in these regions should reveal additional nucleotide variants that are associated with lactase persistence.

Published
2010
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170. Osteomalacia in an HIV-infected man receiving rifabutin, a cytochrome P450 enzyme inducer: a case report

Author

Horne Anne M, Thomas Mark G, Grey Andrew, and Bolland Mark J

Subjects
Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Abstract Introduction People infected with human immunodeficiency virus are frequently treated with medications that can induce or inhibit cytochrome P450 enzymes. Case presentation A 59 year old man treated with zidovudine, lamivudine, indinavir, and ritonavir for infection with human immunodeficiency virus volunteered to take part in a study of bone loss. He was found to have vitamin D insufficiency with secondary hyperparathyroidism and received vitamin D and calcium supplementation. He suffered a recurrence of infection with Mycobacterium avium intracellulare for which he received treatment with ciprofloxacin, rifabutin, and ethambutol. Subsequently, he developed worsening vitamin D deficiency with hypocalcaemia, secondary hyperparathyroidism and elevated markers of bone turnover culminating in an osteomalacic vertebral fracture. Correction of the vitamin D deficiency required 100,000 IU of cholecalciferol monthly. Rifabutin is a cytochrome P450 inducer, and vitamin D and its metabolites are catabolised by cytochrome P450 enzymes. We therefore propose that treatment with rifabutin led to the induction of cytochrome P450 enzymes catabolising vitamin D, thereby causing vitamin D deficiency and osteomalacia. This process might be mediated through the steroid and xenobiotic receptor (SXR). Conclusion Treatment with rifabutin induces the cytochrome P450 enzymes that metabolise vitamin D and patients treated with rifabutin might be at increased risk of vitamin D deficiency. In complex medication regimens involving agents that induce or inhibit cytochrome P450 enzmyes, consultation with a clinical pharmacist or pharmacologist may be helpful in predicting and/or preventing potentially harmful interactions.

Published
2008
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171. The Beaker phenomenon and the genomic transformation of northwest Europe

Author

Olalde, Iñigo, Brace, Selina, Allentoft, Morten E., Armit, Ian, Kristiansen, Kristian, Booth, Thomas, Rohland, Nadin, Mallick, Swapan, Szécsényi-nagy, Anna, Mittnik, Alissa, Altena, Eveline, Lipson, Mark, Lazaridis, Iosif, Harper, Thomas K., Patterson, Nick, Broomandkhoshbacht, Nasreen, Diekmann, Yoan, Faltyskova, Zuzana, Fernandes, Daniel, Ferry, Matthew, Harney, Eadaoin, De Knijff, Peter, Michel, Megan, Oppenheimer, Jonas, Stewardson, Kristin, Barclay, Alistair, Alt, Kurt Werner, Liesau, Corina, Ríos, Patricia, Blasco, Concepción, Miguel, Jorge Vega, García, Roberto Menduiña, Fernández, Azucena Avilés, Bánffy, Eszter, Bernabò-brea, Maria, Billoin, David, Bonsall, Clive, Bonsall, Laura, Allen, Tim, Büster, Lindsey, Carver, Sophie, Navarro, Laura Castells, Craig, Oliver E., Cook, Gordon T., Cunliffe, Barry, Denaire, Anthony, Dinwiddy, Kirsten Egging, Dodwell, Natasha, Ernée, Michal, Evans, Christopher, Kuchařík, Milan, Farré, Joan Francès, Fowler, Chris, Gazenbeek, Michiel, Pena, Rafael Garrido, Haber-uriarte, María, Haduch, Elżbieta, Hey, Gill, Jowett, Nick, Knowles, Timothy, Massy, Ken, Pfrengle, Saskia, Lefranc, Philippe, Lemercier, Olivier, Lefebvre, Arnaud, Martínez, César Heras, Olmo, Virginia Galera, Ramírez, Ana Bastida, Maurandi, Joaquín Lomba, Majó, Tona, Mckinley, Jacqueline I., Mcsweeney, Kathleen, Mende, Balázs Gusztáv, Mod, Alessandra, Kulcsár, Gabriella, Kiss, Viktória, Czene, András, Patay, Róbert, Endrődi, Anna, Köhler, Kitti, Hajdu, Tamás, Szeniczey, Tamás, Dani, János, Bernert, Zsolt, Hoole, Maya, Cheronet, Olivia, Keating, Denise, Velemínský, Petr, Dobeš, Miroslav, Candilio, Francesca, Brown, Fraser, Fernández, Raúl Flores, Herrero-corral, Ana-mercedes, Tusa, Sebastiano, Carnieri, Emiliano, Lentini, Luigi, Valenti, Antonella, Zanini, Alessandro, Waddington, Clive, Delibes, Germán, Guerra-doce, Elisa, Neil, Benjamin, Brittain, Marcus, Luke, Mike, Mortimer, Richard, Desideri, Jocelyne, Besse, Marie, Brücken, Günter, Furmanek, Mirosław, Hałuszko, Agata, Mackiewicz, Maksym, Rapiński, Artur, Leach, Stephany, Soriano, Ignacio, Lillios, Katina T., Cardoso, João Luís, Pearson, Michael Parker, Włodarczak, Piotr, Price, T. Douglas, Prieto, Pilar, Rey, Pierre-jérôme, Risch, Roberto, Rojo Guerra, Manuel A., Schmitt, Aurore, Serralongue, Joël, Silva, Ana Maria, Smrčka, Václav, Vergnaud, Luc, Zilhão, João, Caramelli, David, Higham, Thomas, Thomas, Mark G., Kennett, Douglas J., Fokkens, Harry, Heyd, Volker, Sheridan, Alison, Sjögren, Karl-göran, Stockhammer, Philipp W., Krause, Johannes, Pinhasi, Ron, Haak, Wolfgang, Barnes, Ian, Lalueza-fox, Carles, Reich, David, Olalde, Iñigo, Brace, Selina, Allentoft, Morten E., Armit, Ian, Kristiansen, Kristian, Booth, Thomas, Rohland, Nadin, Mallick, Swapan, Szécsényi-nagy, Anna, Mittnik, Alissa, Altena, Eveline, Lipson, Mark, Lazaridis, Iosif, Harper, Thomas K., Patterson, Nick, Broomandkhoshbacht, Nasreen, Diekmann, Yoan, Faltyskova, Zuzana, Fernandes, Daniel, Ferry, Matthew, Harney, Eadaoin, De Knijff, Peter, Michel, Megan, Oppenheimer, Jonas, Stewardson, Kristin, Barclay, Alistair, Alt, Kurt Werner, Liesau, Corina, Ríos, Patricia, Blasco, Concepción, Miguel, Jorge Vega, García, Roberto Menduiña, Fernández, Azucena Avilés, Bánffy, Eszter, Bernabò-brea, Maria, Billoin, David, Bonsall, Clive, Bonsall, Laura, Allen, Tim, Büster, Lindsey, Carver, Sophie, Navarro, Laura Castells, Craig, Oliver E., Cook, Gordon T., Cunliffe, Barry, Denaire, Anthony, Dinwiddy, Kirsten Egging, Dodwell, Natasha, Ernée, Michal, Evans, Christopher, Kuchařík, Milan, Farré, Joan Francès, Fowler, Chris, Gazenbeek, Michiel, Pena, Rafael Garrido, Haber-uriarte, María, Haduch, Elżbieta, Hey, Gill, Jowett, Nick, Knowles, Timothy, Massy, Ken, Pfrengle, Saskia, Lefranc, Philippe, Lemercier, Olivier, Lefebvre, Arnaud, Martínez, César Heras, Olmo, Virginia Galera, Ramírez, Ana Bastida, Maurandi, Joaquín Lomba, Majó, Tona, Mckinley, Jacqueline I., Mcsweeney, Kathleen, Mende, Balázs Gusztáv, Mod, Alessandra, Kulcsár, Gabriella, Kiss, Viktória, Czene, András, Patay, Róbert, Endrődi, Anna, Köhler, Kitti, Hajdu, Tamás, Szeniczey, Tamás, Dani, János, Bernert, Zsolt, Hoole, Maya, Cheronet, Olivia, Keating, Denise, Velemínský, Petr, Dobeš, Miroslav, Candilio, Francesca, Brown, Fraser, Fernández, Raúl Flores, Herrero-corral, Ana-mercedes, Tusa, Sebastiano, Carnieri, Emiliano, Lentini, Luigi, Valenti, Antonella, Zanini, Alessandro, Waddington, Clive, Delibes, Germán, Guerra-doce, Elisa, Neil, Benjamin, Brittain, Marcus, Luke, Mike, Mortimer, Richard, Desideri, Jocelyne, Besse, Marie, Brücken, Günter, Furmanek, Mirosław, Hałuszko, Agata, Mackiewicz, Maksym, Rapiński, Artur, Leach, Stephany, Soriano, Ignacio, Lillios, Katina T., Cardoso, João Luís, Pearson, Michael Parker, Włodarczak, Piotr, Price, T. Douglas, Prieto, Pilar, Rey, Pierre-jérôme, Risch, Roberto, Rojo Guerra, Manuel A., Schmitt, Aurore, Serralongue, Joël, Silva, Ana Maria, Smrčka, Václav, Vergnaud, Luc, Zilhão, João, Caramelli, David, Higham, Thomas, Thomas, Mark G., Kennett, Douglas J., Fokkens, Harry, Heyd, Volker, Sheridan, Alison, Sjögren, Karl-göran, Stockhammer, Philipp W., Krause, Johannes, Pinhasi, Ron, Haak, Wolfgang, Barnes, Ian, Lalueza-fox, Carles, and Reich, David

Published
2018

172. Directly modelling population dynamics in the South American Arid Diagonal using 14C dates.

Author

Timpson, Adrian, Barberena, Ramiro, Thomas, Mark G., Méndez, César, and Manning, Katie

Subjects
POPULATION dynamics, DISTRIBUTION (Probability theory), MARKOV chain Monte Carlo, SAMPLE size (Statistics), POPULATION
Abstract

Large anthropogenic 14C datasets are widely used to generate summed probability distributions (SPDs) as a proxy for past human population levels. However, SPDs are a poor proxy when datasets are small, bearing little relationship to true population dynamics. Instead, more robust inferences can be achieved by directly modelling the population and assessing the model likelihood given the data. We introduce the R package ADMUR which uses a continuous piecewise linear (CPL) model of population change, calculates the model likelihood given a 14C dataset, estimates credible intervals using Markov chain Monte Carlo, applies a goodness-of-fit test, and uses the Schwarz Criterion to compare CPL models. We demonstrate the efficacy of this method using toy data, showing that spurious dynamics are avoided when sample sizes are small, and true population dynamics are recovered as sample sizes increase. Finally, we use an improved 14C dataset for the South American Arid Diagonal to compare CPL modelling to current simulation methods, and identify three Holocene phases when population trajectory estimates changed fromrapid initial growth of 4.15% per generation to a decline of 0.05%per generation between 10 821 and 7055 yr BP, then gently grew at 0.58% per generation until 2500 yr BP [ABSTRACT FROM AUTHOR]

Published
2021
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173. Inferring Allele Frequency Trajectories from Ancient DNA Indicates That Selection on a Chicken Gene Coincided with Changes in Medieval Husbandry Practices

Author

Loog, Liisa, Thomas, Mark G, Barnett, Ross, Allen, Richard, Sykes, Naomi, Paxinos, Ptolemaios D, Lebrasseur, Ophelie, Dobney, Keith, Peters, Joris, Manica, Andrea, Larson, Greger, Eriksson, Anders, Loog, Liisa [0000-0002-1770-101X], Manica, Andrea [0000-0003-1895-450X], Eriksson, Anders [0000-0003-3436-3726], and Apollo - University of Cambridge Repository

Subjects
selection, Bayes Theorem, Receptors, Thyrotropin, Sequence Analysis, DNA, Breeding, Bayesian analyses, TSHR, DNA, Mitochondrial, Poultry, Dioxygenases, domestication, BCDO2, Gene Frequency, Animals, Domestic, Journal Article, Animals, Animal Husbandry, DNA, Ancient, Selection, Genetic, Chickens, ancient DNA, Alleles, Discoveries
Abstract

Ancient DNA provides an opportunity to infer the drivers of natural selection by linking allele frequency changes to temporal shifts in environment or cultural practices. However, analyses have often been hampered by uneven sampling and uncertainties in sample dating, as well as being confounded by demographic processes. Here, we present a Bayesian statistical framework for quantifying the timing and strength of selection using ancient DNA that explicitly addresses these challenges. We applied this method to time series data for two loci: TSHR and BCDO2, both hypothesised to have undergone strong and recent selection in domestic chickens. The derived variant in TSHR, associated with reduced aggression to conspecifics and faster onset of egg laying, shows strong selection beginning around 1,100 years ago, coincident with archaeological evidence for intensified chicken production and documented changes in egg and chicken consumption. To our knowledge, this is the first example of preindustrial domesticate trait selection in response to a historically attested cultural shift in food preference. For BCDO2, we find support for selection, but demonstrate that the recent rise in allele frequency could also have been driven by gene flow from imported Asian chickens during more recent breed formations. Our findings highlight that traits found ubiquitously in modern domestic species may not necessarily have originated during the early stages of domestication. In addition, our results demonstrate the importance of precise estimation of allele frequency trajectories through time for understanding the drivers of selection.

Published
2017

174. Erratum: The Beaker phenomenon and the genomic transformation of northwest Europe

Author

Olalde, Iigo, Brace, Selina, Allentoft, Morten E., Armit, Ian, Kristiansen, Kristian, Booth, Thomas, Rohland, Nadin, Mallick, Swapan, Szcsnyi-Nagy, Anna, Mittnik, Alissa, Altena, Eveline, Lipson, Mark, Lazaridis, Iosif, Harper, Thomas K., Patterson, Nick, Broomandkhoshbacht, Nasreen, Diekmann, Yoan, Faltyskova, Zuzana, Fernandes, Daniel, Ferry, Matthew, Harney, Eadaoin, de Knijff, Peter, Michel, Megan, Oppenheimer, Jonas, Stewardson, Kristin, Barclay, Alistair, Alt, Kurt Werner, Liesau, Corina, Ros, Patricia, Blasco, Concepcin, Miguel, Jorge Vega, Garca, Roberto Menduia, Fernndez, Azucena Avils, Bnffy, Eszter, Bernab-Brea, Maria, Billoin, David, Bonsall, Clive, Bonsall, Laura, Allen, Tim, Bster, Lindsey, Carver, Sophie, Navarro, Laura Castells, Craig, Oliver E., Cook, Gordon T., Cunliffe, Barry, Denaire, Anthony, Dinwiddy, Kirsten Egging, Dodwell, Natasha, Erne, Michal, Evans, Christopher, Kuchak, Milan, Farr, Joan Francs, Fowler, Chris, Gazenbeek, Michiel, Pena, Rafael Garrido, Haber-Uriarte, Mara, Haduch, Elbieta, Hey, Gill, Jowett, Nick, Knowles, Timothy, Massy, Ken, Pfrengle, Saskia, Lefranc, Philippe, Lemercier, Olivier, Lefebvre, Arnaud, Martnez, Csar Heras, Olmo, Virginia Galera, Ramrez, Ana Bastida, Maurandi, Joaqun Lomba, Maj, Tona, McKinley, Jacqueline I., McSweeney, Kathleen, Mende, Balzs Gusztv, Modi, Alessandra, Kulcsr, Gabriella, Kiss, Viktria, Czene, Andrs, Patay, Rbert, Endrdi, Anna, Khler, Kitti, Hajdu, Tams, Szeniczey, Tams, Dani, Jnos, Bernert, Zsolt, Hoole, Maya, Cheronet, Olivia, Keating, Denise, Velemnsk, Petr, Dobe, Miroslav, Candilio, Francesca, Brown, Fraser, Fernndez, Ral Flores, Herrero-Corral, Ana-Mercedes, Tusa, Sebastiano, Carnieri, Emiliano, Lentini, Luigi, Valenti, Antonella, Zanini, Alessandro, Waddington, Clive, Delibes, Germn, Guerra-Doce, Elisa, Neil, Benjamin, Brittain, Marcus, Luke, Mike, Mortimer, Richard, Desideri, Jocelyne, Besse, Marie, Brcken, Gnter, Furmanek, Mirosaw, Hauszko, Agata, Mackiewicz, Maksym, Rapiski, Artur, Leach, Stephany, Soriano, Ignacio, Lillios, Katina T., Cardoso, Joo Lus, Pearson, Michael Parker, Wodarczak, Piotr, Price, T. Douglas, Prieto, Pilar, Rey, Pierre-Jrme, Risch, Roberto, Guerra, Manuel A. Rojo, Schmitt, Aurore, Serralongue, Jol, Silva, Ana Maria, Smrka, Vclav, Vergnaud, Luc, Zilho, Joo, Caramelli, David, Higham, Thomas, Thomas, Mark G., Kennett, Douglas J., Fokkens, Harry, Heyd, Volker, Sheridan, Alison, Sjgren, Karl-Gran, Stockhammer, Philipp W., Krause, Johannes, Pinhasi, Ron, Haak, Wolfgang, Barnes, Ian, Lalueza-Fox, Carles, and Reich, David

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Iigo Olalde; Selina Brace; Morten E. Allentoft; Ian Armit; Kristian Kristiansen; Thomas Booth; Nadin Rohland; Swapan Mallick; Anna Szcsnyi-Nagy; Alissa Mittnik; Eveline Altena; Mark Lipson; Iosif Lazaridis; Thomas K. [...]

Published
2018
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175. ‘Ava’: a Beaker-associated woman from a cist at Achavanich, Highland, and the story of her (re-)discovery and subsequent study

Author

Hoole, Maya, primary, Sheridan, Alison, primary, Boyle, Angela, primary, Booth, Thomas, primary, Brace, Selina, primary, Diekmann, Yoan, primary, Olalde, Iñigo, primary, Thomas, Mark G, primary, Barnes, Ian, primary, Evans, Jane, primary, Chenery, Carolyn, primary, Sloane, Hilary, primary, Morrison, Hew, primary, Fraser, Sheena, primary, Timpany, Scott, primary, and Hamilton, Derek, primary

Published
2018
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178. Genetic diversity of CHC22 clathrin impacts its function in glucose metabolism

Author

Fumagalli, Matteo, primary, Camus, Stephane M., additional, Diekmann, Yoan, additional, Burke, Alice, additional, Camus, Marine D., additional, Norman, Paul J., additional, Joseph, Agnel Praveen, additional, Abi-Rached, Laurent, additional, Benazzo, Andrea, additional, Rasteiro, Rita, additional, Mathieson, Iain, additional, Topf, Maya, additional, Parham, Peter, additional, Thomas, Mark G., additional, and Brodsky, Frances M., additional

Published
2018
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179. Population Replacement in Early Neolithic Britain

Author

Brace, Selina, primary, Diekmann, Yoan, additional, Booth, Thomas J., additional, Faltyskova, Zuzana, additional, Rohland, Nadin, additional, Mallick, Swapan, additional, Ferry, Matthew, additional, Michel, Megan, additional, Oppenheimer, Jonas, additional, Broomandkhoshbacht, Nasreen, additional, Stewardson, Kristin, additional, Walsh, Susan, additional, Kayser, Manfred, additional, Schulting, Rick, additional, Craig, Oliver E., additional, Sheridan, Alison, additional, Pearson, Mike Parker, additional, Stringer, Chris, additional, Reich, David, additional, Thomas, Mark G., additional, and Barnes, Ian, additional

Published
2018
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180. Synchronous diversification of Sulawesi’s iconic artiodactyls driven by recent geological events

Author

Frantz, Laurent A. F., primary, Rudzinski, Anna, additional, Nugraha, Abang Mansyursyah Surya, additional, Evin, Allowen, additional, Burton, James, additional, Hulme-Beaman, Ardern, additional, Linderholm, Anna, additional, Barnett, Ross, additional, Vega, Rodrigo, additional, Irving-Pease, Evan K., additional, Haile, James, additional, Allen, Richard, additional, Leus, Kristin, additional, Shephard, Jill, additional, Hillyer, Mia, additional, Gillemot, Sarah, additional, van den Hurk, Jeroen, additional, Ogle, Sharron, additional, Atofanei, Cristina, additional, Thomas, Mark G., additional, Johansson, Friederike, additional, Haris Mustari, Abdul, additional, Williams, John, additional, Mohamad, Kusdiantoro, additional, Damayanti, Chandramaya Siska, additional, Wiryadi, Ita Djuwita, additional, Obbles, Dagmar, additional, Mona, Stephano, additional, Day, Hally, additional, Yasin, Muhammad, additional, Meker, Stefan, additional, McGuire, Jimmy A., additional, Evans, Ben J., additional, von Rintelen, Thomas, additional, Ho, Simon Y. W., additional, Searle, Jeremy B., additional, Kitchener, Andrew C., additional, Macdonald, Alastair A., additional, Shaw, Darren J., additional, Hall, Robert, additional, Galbusera, Peter, additional, and Larson, Greger, additional

Published
2018
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182. Disentangling Immediate Adaptive Introgression from Selection on Standing Introgressed Variation in Humans

Author

Jagoda, Evelyn, primary, Lawson, Daniel J, additional, Wall, Jeffrey D, additional, Lambert, David, additional, Muller, Craig, additional, Westaway, Michael, additional, Leavesley, Matthew, additional, Capellini, Terence D, additional, Mirazón Lahr, Marta, additional, Gerbault, Pascale, additional, Thomas, Mark G, additional, Migliano, Andrea Bamberg, additional, Willerslev, Eske, additional, Metspalu, Mait, additional, and Pagani, Luca, additional

Published
2017
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187. Early Neolithic genomes from the eastern Fertile Crescent

Author

Broushaki, Farnaz, Thomas, Mark G., Link, Vivian, López, Saioa, van Dorp, Lucy, Kirsanow, Karola, Hofmanová, Zuzana, Diekmann, Yoan, M. Cassidy, Lara, Díez-del-Molino, David, Kousathanas, Athanasios, Sell, Christian, Robson, Harry Kenneth, Martiniano, Rui, Blöcher, Jens, Scheu, Amelie, Kreutzer, Susanne, Bollongino, Ruth, Bobo, Dean, Davudi, Hossein, Munoz, Olivia, Currat, Mathias, Abdi, Kamyar, Biglari, Fereidoun, Craig, Oliver Edward, G Bradley, Daniel, Shennan, Stephen, R Veeramah, Krishna, Mashkour, Marjan, Wegmann, Daniel, Hellenthal, Garrett, Burger, Joachim, Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), and Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.EE]Life Sciences [q-bio]/Ecology, environment, [SDV.GEN]Life Sciences [q-bio]/Genetics, Ancient DNA, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Genome, Human, Human Migration, Afghanistan, Genetic Variation, Agriculture, Genomics, Iran, White People, Article, 570 Life sciences, [SHS]Humanities and Social Sciences, ddc:590, Ethnicity, Humans, Pakistan, Neolithic, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], History, Ancient, ComputingMilieux_MISCELLANEOUS, 570 Biowissenschaften
Abstract

We sequenced Early Neolithic genomes from the Zagros region of Iran (eastern Fertile Crescent), where some of the earliest evidence for farming is found, and identify a previously uncharacterized population that is neither ancestral to the first European farmers nor has contributed substantially to the ancestry of modern Europeans. These people are estimated to have separated from Early Neolithic farmers in Anatolia some 46,000 to 77,000 years ago and show affinities to modern-day Pakistani and Afghan populations, but particularly to Iranian Zoroastrians. We conclude that multiple, genetically differentiated hunter-gatherer populations adopted farming in southwestern Asia, that components of pre-Neolithic population structure were preserved as farming spread into neighboring regions, and that the Zagros region was the cradle of eastward expansion.

Published
2016

191. In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism

Author

Salvatori, Roberto, primary, Radian, Serban, additional, Diekmann, Yoan, additional, Iacovazzo, Donato, additional, David, Alessia, additional, Gabrovska, Plamena, additional, Grassi, Giorgia, additional, Bussell, Anna-Marie, additional, Stals, Karen, additional, Weber, Astrid, additional, Quinton, Richard, additional, Crowne, Elizabeth C, additional, Corazzini, Valentina, additional, Metherell, Lou, additional, Kearney, Tara, additional, Du Plessis, Daniel, additional, Sinha, Ajay Kumar, additional, Baborie, Atik, additional, Lecoq, Anne-Lise, additional, Chanson, Philippe, additional, Ansorge, Olaf, additional, Ellard, Sian, additional, Trainer, Peter J, additional, Balding, David, additional, Thomas, Mark G, additional, and Korbonits, Márta, additional

Published
2017
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192. Reconstructing Prehistoric African Population Structure

Author

Skoglund, Pontus, primary, Thompson, Jessica C., additional, Prendergast, Mary E., additional, Mittnik, Alissa, additional, Sirak, Kendra, additional, Hajdinjak, Mateja, additional, Salie, Tasneem, additional, Rohland, Nadin, additional, Mallick, Swapan, additional, Peltzer, Alexander, additional, Heinze, Anja, additional, Olalde, Iñigo, additional, Ferry, Matthew, additional, Harney, Eadaoin, additional, Michel, Megan, additional, Stewardson, Kristin, additional, Cerezo-Román, Jessica I., additional, Chiumia, Chrissy, additional, Crowther, Alison, additional, Gomani-Chindebvu, Elizabeth, additional, Gidna, Agness O., additional, Grillo, Katherine M., additional, Helenius, I. Taneli, additional, Hellenthal, Garrett, additional, Helm, Richard, additional, Horton, Mark, additional, López, Saioa, additional, Mabulla, Audax Z.P., additional, Parkington, John, additional, Shipton, Ceri, additional, Thomas, Mark G., additional, Tibesasa, Ruth, additional, Welling, Menno, additional, Hayes, Vanessa M., additional, Kennett, Douglas J., additional, Ramesar, Raj, additional, Meyer, Matthias, additional, Pääbo, Svante, additional, Patterson, Nick, additional, Morris, Alan G., additional, Boivin, Nicole, additional, Pinhasi, Ron, additional, Krause, Johannes, additional, and Reich, David, additional

Published
2017
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193. The Genetic Legacy of Zoroastrianism in Iran and India: Insights into Population Structure, Gene Flow, and Selection

Author

López, Saioa, primary, Thomas, Mark G., additional, van Dorp, Lucy, additional, Ansari-Pour, Naser, additional, Stewart, Sarah, additional, Jones, Abigail L., additional, Jelinek, Erik, additional, Chikhi, Lounès, additional, Parfitt, Tudor, additional, Bradman, Neil, additional, Weale, Michael E., additional, and Hellenthal, Garrett, additional

Published
2017
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194. Accurate age estimation in small-scale societies

Author

Diekmann, Yoan, primary, Smith, Daniel, additional, Gerbault, Pascale, additional, Dyble, Mark, additional, Page, Abigail E., additional, Chaudhary, Nikhil, additional, Migliano, Andrea Bamberg, additional, and Thomas, Mark G., additional

Published
2017
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195. The Beaker Phenomenon and the Genomic Transformation of Northwest Europe

Author

Olalde, Iñigo, primary, Brace, Selina, additional, Allentoft, Morten E., additional, Armit, Ian, additional, Kristiansen, Kristian, additional, Rohland, Nadin, additional, Mallick, Swapan, additional, Booth, Thomas, additional, Szécsényi-Nagy, Anna, additional, Mittnik, Alissa, additional, Altena, Eveline, additional, Lipson, Mark, additional, Lazaridis, Iosif, additional, Patterson, Nick, additional, Broomandkhoshbacht, Nasreen, additional, Diekmann, Yoan, additional, Faltyskova, Zuzana, additional, Fernandes, Daniel, additional, Ferry, Matthew, additional, Harney, Eadaoin, additional, Knijff, Peter de, additional, Michel, Megan, additional, Oppenheimer, Jonas, additional, Stewardson, Kristin, additional, Barclay, Alistair, additional, Alt, Kurt W., additional, Avilés Fernández, Azucena, additional, Bánffy, Eszter, additional, Bernabò-Brea, Maria, additional, Billoin, David, additional, Blasco, Concepción, additional, Bonsall, Clive, additional, Bonsall, Laura, additional, Allen, Tim, additional, Büster, Lindsey, additional, Carver, Sophie, additional, Navarro, Laura Castells, additional, Craig, Oliver Edward, additional, Cook, Gordon T., additional, Cunliffe, Barry, additional, Denaire, Anthony, additional, Dinwiddy, Kirsten Egging, additional, Dodwell, Natasha, additional, Ernée, Michal, additional, Evans, Christopher, additional, Kuchařík, Milan, additional, Francès Farré, Joan, additional, Fokkens, Harry, additional, Fowler, Chris, additional, Gazenbeek, Michiel, additional, Pena, Rafael Garrido, additional, Haber-Uriarte, María, additional, Haduch, Elżbieta, additional, Hey, Gill, additional, Jowett, Nick, additional, Knowles, Timothy, additional, Massy, Ken, additional, Pfrengle, Saskia, additional, Lefranc, Philippe, additional, Lemercier, Olivier, additional, Lefebvre, Arnaud, additional, Lomba Maurandi, Joaquín, additional, Majó, Tona, additional, McKinley, Jacqueline I., additional, McSweeney, Kathleen, additional, Balázs Gusztáv, Mende, additional, Modi, Alessandra, additional, Kulcsár, Gabriella, additional, Kiss, Viktória, additional, Czene, András, additional, Patay, Róbert, additional, Endrődi, Anna, additional, Köhler, Kitti, additional, Hajdu, Tamás, additional, Cardoso, João Luís, additional, Liesau, Corina, additional, Pearson, Michael Parker, additional, Włodarczak, Piotr, additional, Douglas Price, T., additional, Prieto, Pilar, additional, Rey, Pierre-Jérôme, additional, Ríos, Patricia, additional, Risch, Roberto, additional, Rojo Guerra, Manuel A., additional, Schmitt, Aurore, additional, Serralongue, Joël, additional, Silva, Ana Maria, additional, Smrčka, Václav, additional, Vergnaud, Luc, additional, Zilhão, João, additional, Caramelli, David, additional, Higham, Thomas, additional, Heyd, Volker, additional, Sheridan, Alison, additional, Sjögren, Karl-Göran, additional, Thomas, Mark G., additional, Stockhammer, Philipp W., additional, Pinhasi, Ron, additional, Krause, Johannes, additional, Haak, Wolfgang, additional, Barnes, Ian, additional, Lalueza-Fox, Carles, additional, and Reich, David, additional

Published
2017
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196. Inferring Allele Frequency Trajectories from Ancient DNA Indicates That Selection on a Chicken Gene Coincided with Changes in Medieval Husbandry Practices

Author

Loog, Liisa, primary, Thomas, Mark G., additional, Barnett, Ross, additional, Allen, Richard, additional, Sykes, Naomi, additional, Paxinos, Ptolemaios D., additional, Lebrasseur, Ophélie, additional, Dobney, Keith, additional, Peters, Joris, additional, Manica, Andrea, additional, Larson, Greger, additional, and Eriksson, Anders, additional

Published
2017
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200. Simulating geographical variation in material culture : were Early Modern Humans in Europe ethnically structured ?

Author

Kovacevic, Mirna, Shennan, Stephen, Vanhaeren, Marian, d'Errico, Francesco, Thomas, Mark G., University College of London [London] (UCL), Archéologies et Sciences de l'Antiquité (ArScAn), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), De la Préhistoire à l'Actuel : Culture, Environnement et Anthropologie (PACEA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Mesoudi, A. and Aoki, K., Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), and Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris 8 Vincennes-Saint-Denis (UP8)-Université Paris Nanterre (UPN)-Ministère de la Culture et de la Communication (MCC)-Institut national de recherches archéologiques préventives (Inrap)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2015

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