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Síndrome de fatiga crònica; Diferències de gènere; Variabilitat de la freqüència cardíaca Síndrome de fatiga crónica; Diferencias de género; Variabilidad del ritmo cardíaco Chronic fatigue syndrome; Gender differences; Heart rate variability In a previous study using mobile-health technology (mHealth), we reported a robust association between chronic fatigue symptoms and heart rate variability (HRV) in female patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study explores HRV analysis as an objective, non-invasive and easy-to-apply marker of ME/CFS using mHealth technology, and evaluates differential gender effects on HRV and ME/CFS core symptoms. In our methodology, participants included 77 ME/CFS patients (32 men and 45 women) and 44 age-matched healthy controls (19 men and 25 women), all self-reporting subjective scores for fatigue, sleep quality, anxiety, and depression, and neurovegetative symptoms of autonomic dysfunction. The inter-beat cardiac intervals are continuously monitored/recorded over three 5-min periods, and HRV is analyzed using a custom-made application (iOS) on a mobile device connected via Bluetooth to a wearable cardiac chest band. Male ME/CFS patients show increased scores compared with control men in all symptoms and scores of fatigue, and autonomic dysfunction, as with women in the first study. No differences in any HRV parameter appear between male ME/CFS patients and controls, in contrast to our findings in women. However, we have found negative correlations of ME/CFS symptomatology with cardiac variability (SDNN, RMSSD, pNN50, LF) in men. We have also found a significant relationship between fatigue symptomatology and HRV parameters in ME/CFS patients, but not in healthy control men. Gender effects appear in HF, LF/HF, and HFnu HRV parameters. A MANOVA analysis shows differential gender effects depending on the experimental condition in autonomic dysfunction symptoms and HF and HFnu HRV parameters. A decreased HRV pattern in ME/CFS women compared to ME/CFS men may reflect a sex-related cardiac autonomic dysfunction in ME/CFS illness that could be used as a predictive marker of disease progression. In conclusion, we show that HRV analysis using mHealth technology is an objective, non-invasive tool that can be useful for clinical prediction of fatigue severity, especially in women with ME/CFS. This research was funded by “Ministerio de Ciencia e Innovación” of the Spanish Government, grant number PID2019-107473RB-C2.

Objectius de Desenvolupament Sostenible::3 - Salut i Benestar

Background—The aim was to determine the influence of sonic activation in the tubular dentine penetration of bioceramic sealers. Methods—Forty mesiobuccal curved root canals of mandibular molars with an apical diameter smaller than #30 were prepared, divided into two groups, and filled with EndoSequence BC sealer, with or without sonic activation during its placement. Roots were sectioned at 3 mm, 6 mm, and 9 mm from the apex, producing a sample size of 120. The samples were evaluated using a confocal laser scanning microscope and comparing these images to the images obtained from an operatory microscope. The percentage of sealer penetration and maximum sealer penetration were evaluated. Statistical analysis was performed using the two-tailed Mann–Whitney U test, where statistical significance was set to p &lt, 0.05. Results—Sonic activation showed higher values for the percentage of sealer penetration when compared at the 9 mm level (p = 0.03). A higher value of maximum sealer penetration was observed at all levels when the sealer was activated. Conclusions—The sonic activation of bioceramic cement resulted in higher sealer penetration into dentinal tubules.

Simple Summary This study aimed to evaluate the efficacy of treating the surface of dental implants with carboxyethylphosphonic acid for the immobilization of FGF-2, the influence of FGF-2 on cortical bone in close contact with dental implants, new bone formation around dental implants in the presence of FGF-2 and the influence of FGF-2 on the interthread bone area of dental implants during the healing period after insertion. Abstract The aim of this study was to evaluate the effect of implant surface treatment with carboxyethylphosphonic acid and fibroblast growth factor 2 on the bone–implant interface during the osseointegration period in vivo using an animal model. The present research was carried out in six minipigs, in whose left tibia implants were inserted as follows: eight implants with a standard surface treatment, for the control group, and eight implants with a surface treatment of carboxyethylphosphonic acid and immobilization of FGF-2, for the test group. At 4 weeks after the insertion of the implants, the animals were sacrificed for the histomorphometric analysis of the samples. The means of the results for the implant–bone contact variable (BIC) were 46.39 ± 17.49% for the test group and 34.00 ± 9.92% for the control group; the difference was not statistically significant. For the corrected implant–bone contact variable (BICc), the mean value of the test group was 60.48 ± 18.11%, and that for the control group, 43.08 ± 10.77%; the difference was statistically significant (p-value = 0.035). The new bone formation (BV/TV) showed average results of 27.28 ± 3.88% for the test group and 26.63 ± 7.90% for the control group, meaning that the differences were not statistically significant (p-value = 0.839). Regarding the bone density at the interthread level (BAI/TA), the mean value of the test group was 32.27 ± 6.70%, and that of the control group was 32.91 ± 7.76%, with a p-value of 0.863, while for the peri-implant density (BAP/TA), the mean value of the test group was 44.96 ± 7.55%, and that for the control group was 44.80 ± 8.68%, without a significant difference between the groups. The current research only found a significant difference for the bone–implant contact at the cortical level; therefore, it could be considered that FGF-2 acts on the mineralization of bone tissue. The application of carboxyethylphosphonic acid on the surface of implants can be considered a promising alternative as a biomimetic coating for the immobilization of FGF-2. Despite no differences in the new bone formation around the implants or in the interthread or peri-implant bone density being detected, the biofunctionalization of the implant surface with FGF-2 accelerates the mineralization of the bone–implant interface at the cortical level, thereby reducing the osseointegration period.

Este libro se realizó con el objetivo de proponer estrategias organizacionales para mejorar el clima laboral en una Escuela Profesional de Tecnología Médica del Perú. Para el recojo de la información de la unidad de análisis se aplicaron encuestas, observación, entrevistas estructuradas y en profundidad y testimonios sobre el clima laboral. Luego de haber terminado esta parte la naturaleza del problema de investigación definió la base teórica que sirvió de fundamento a la propuesta. Los resultados confirman que el clima laboral es inadecuado expresado en el hecho de que los docentes califican la actitud de las autoridades desfavorable, puesto que no les comunican con precisión ni claridad las actividades que se van a realizar en la Escuela Profesional de Tecnología Médica, toman decisiones sin consultar, desconocen los problemas que tienen los docentes, no son motivados; además los docentes reciben influencias negativas que les perjudica su clima laboral. Se concluyó como logros de la investigación, por un lado, la justificación del problema, es decir, haber confirmado la hipótesis y haber dado cuenta de la naturaleza del problema; por el otro presentar la propuesta, articulando la base teórica con la propuesta en mérito a la fundamentación de los talleres.

Background: The treatment of floaters has consisted primarily of monitoring. The therapeutic approach is based on surgical removal or Nd:YAG laser treatment. The objective of this study was the assessment of the quality of life in patients treated with Nd:YAG laser for floaters. Methods: Single-center pretest-posttest design in a cohort of subjects treated with Nd-YAG laser with Ultra Q-Reflex technology. Health-related quality of life of the patients was measured before and after the intervention with the Visual Function Questionnaires VFQ-25 and VFQ-39. Anxiety level was measured with the State-Trait Anxiety Inventory. Visual acuity, contrast sensitivity, and safety parameters were also considered. Results: Thirty-four patients were included in the study. For the VFQ-25 baseline, the median was 73.05, interquartile range (19.25) versus a final median value of 93.76 (8.73) with p Conclusions: This study shows an improvement in the health-related quality of life and a significant decrease in anxiety for patients that have undergone Nd: YAG Ultra-Q Reflex laser vitreolysis for floaters vaporization. The effect found is higher in myopic patients.

En el desarrollo del documento se podrán identificar características importantes acerca de la adecuada evaluación de proveedores que ofertan productos y servicios enfocados a la tecnología médica de calidad, las instituciones de salud deben responder y ofrecer excelencia en el servicio persistentemente pensando en lo mejor para el paciente, haciendo énfasis en la promoción y prevención, esto anterior pretende enfatizar en la importancia de una correcta evaluación al momento de adquirir tecnología médica, es vital e importante tener una rigurosa revisión de esta maquinaria pues será la que estará directamente relacionada con el paciente, no existe una metodología establecida a nivel nacional de que parámetros y características deben buscar las IPS cuándo adquieren tecnología nueva, no se sabe si es necesario incluir ítems pues para algunas son necesarios pero para otras no, se logrará identificar a lo largo del documento que parámetros se hacen indispensables al momento de evaluar tecnología y seleccionar un proveedor de la misma y la importancia que esto tiene en la oferta de servicios de salud. In the development of the document it will be possible to identify important characteristics about the adequate evaluation of providers that offer products and services focused on quality medical technology, health institutions must respond and offer excellence in service persistently thinking about the best for the patient , emphasizing promotion and prevention, this above aims to emphasize the importance of a correct evaluation when acquiring medical technology, it is vital and important to have a rigorous review of this machinery as it will be the one that will be directly related to the patient, not There is a methodology established at the national level that parameters and characteristics IPS should look for when they acquire new technology, it is not known if it is necessary to include items because for some they are necessary but for others not, it will be possible to identify throughout the document which parameters are make essential when evaluating techno and select a provider of the same and the importance of the offer to service health. Especialización No desenvolvimento do documento será possível identificar características importantes sobre a avaliação adequada de prestadores que oferecem produtos e serviços com foco em tecnologia médica de qualidade, as instituições de saúde devem responder e oferecer excelência no atendimento pensando persistentemente no melhor para o paciente, enfatizando promoção e prevenção, este acima visa enfatizar a importância de uma avaliação correta na aquisição de tecnologia médica, é vital e importante uma revisão rigorosa deste maquinário, pois será aquele que estará diretamente relacionado ao paciente, não lá é uma metodologia estabelecida a nível nacional que os parâmetros e características que os IPS devem procurar ao adquirir uma nova tecnologia, não se sabe se é necessário incluir itens porque para uns são necessários mas para outros não será possível identificar ao longo do documento quais parâmetros são essenciais ao avaliar o techno e selecionar um fornecedor er do mesmo e a importância da oferta ao serviço de saúde.

O uso de aplicativos móveis e dispositivos vestíveis, combinados com a capacidade da cloud computing (CC) para armazenar e processar grandes volumes de dados de saúde e bem-estar, oferecem capacidades de acesso instantâneo e o compartilhamento ágil das informações. No entanto, o volume de informações geradas e o fato delas trafegarem pela Internet pode aumentar as preocupações dos indivíduos no que tange sua privacidade e sua intenção em divulgar informações de saúde e bem-estar em aplicativos móveis que usam cloud computing (mHealth). Para investigar como as preocupações dos indivíduos acerca da privacidade afetam seu comportamento em compartilhar dados de saúde em plataformas m-Health foi usado o modelo Mobile Users’ Information Privacy Concerns (MUIPC). Os resultados foram analisados por meio do método partial least squares (PLS-SEM) e foi demonstrado que as preocupações com privacidade da informação influenciam principalmente o comportamento dos indivíduos de meia idade e idosos na divulgação de dados no uso de m-Health. Este estudo foi baseado em uma pesquisa on-line que alcançou 300 participantes. As descobertas deste estudo fornecem uma visão abrangente que traz contribuições para a teoria, por demonstrar a aplicação do modelo MUIPC como um instrumento válido para explorar as preocupações privacidade no uso de aplicativos móveis e CC na área de saúde, mas também o papel moderador das variáveis de controle sociodemográficas como gênero, renda e idade. Para prática, as contribuições estão na apresentação das implicações do uso de m-Health aos interessados de saúde na direção de centralizar as informações de saúde do paciente e facilitar a colaboração. The use of mobile apps and wearable devices, combined with the ability of cloud computing (CC) to store and process large volumes of health and wellness data, offer instant access capabilities and agile information sharing. However, the volume of information generated and the fact that it travels over the Internet can increase individuals’ concerns about privacy and their intention to disclose health and well-being information in mobile applications that use cloud computing (m-Health). To investigate how individuals' privacy concerns affect their behavior in sharing health data on m-Health platforms, it was used the Mobile Users’ Information Privacy Concerns (MUIPC) model. The results were analyzed using the partial least squares method (PLS-SEM) and they demonstrated that the individuals’ concerns with information privacy influence mainly the behavior of middle-aged and elderly in the disclosing of data on the use of m-Health. This study was based on an online survey that reached 300 participants. The findings of this study provide a comprehensive view that brings contributions to the theory, as it demonstrates the application of the MUIPC model as a valid instrument to explore privacy concerns in the use of mobile applications and CC in the health field, but also the moderating role of the sociodemographic variables controls such as gender, income and age. To practice, the contributions are related to the implications of using m-Health usage to health stakeholders in the direction of centralizing patient health information and facilitating the collaboration.

The high infectivity of SARS-CoV-2 makes it essential to develop a rapid and accurate diagnostic test so that carriers can be isolated at an early stage. Viral RNA in nasopharyngeal samples by RT-PCR is currently considered the reference method although it is not recognized as a strong gold standard due to certain drawbacks. Here we develop a methodology combining the analysis of from human nasopharyngeal (NP) samples by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) with the use of machine learning (ML). A total of 236 NP samples collected in two different viral transport media were analyzed with minimal sample preparation and the subsequent mass spectra data was used to build different ML models with two different techniques. The best model showed high performance in terms of accuracy, sensitivity and specificity, in all cases reaching values higher than 90%. Our results suggest that the analysis of NP samples by MALDI-TOF MS and ML is a simple, safe, fast and economic diagnostic test for COVID-19. SAUN—Santander Universidades-CRUE (PEDIEC from FONDO SUPERA COVID-19) 5.093 JCR (2020) Q1, 28/167 Medicine, General & Internal 1.388 SJR (2020) Q1, 304/2446 Medicine (miscellaneous) No data IDR 2020 UEM

Tesis inédita presentada en la Universidad Europea de Madrid. Programa de Doctorado en Biomedicina y Ciencias de la Salud. Escuela de Doctorado e Investigación UEM

Tesis inédita presentada en la Universidad Europea de Madrid. Escuela de Doctorado e Investigación. Programa de Doctorado en Biomedicina y Ciencias de la Salud UEM

Simple Summary Metastasis is the last stage in the development of cancer and usually results in mortality. Cutaneous metastases (CMs) account for 2% of all skin malignancies. Nearly 70% of CMs in women originate from breast cancer (BC). Since CM is usually associated with poor prognosis, the development of management strategies for these patients remains an important clinical challenge. Identifying molecular markers in primary BC that predict CMs and determining the molecular differences between primary tumors and their metastases is of great interest for designing new therapeutic approaches. Abstract Cutaneous metastases (CMs) account for 2% of all skin malignancies, and nearly 70% of CMs in women originate from breast cancer (BC). CMs are usually associated with poor prognosis, are difficult to treat, and can pose diagnostic problems, such as in histopathological diagnosis when occurring long after development of the primary tumor. In addition, the molecular differences between the primary tumors and their CMs, and between CMs and metastases in other organs, are not well defined. Here, we review the main clinical, pathological, and molecular characteristics of breast cancer CMs. Identifying molecular markers in primary BC that predict CM and can be used to determine the molecular differences between primary tumors and their metastases is of great interest for the design of new therapeutic approaches.

Sin financiación No data JCR 2021 0.385 SJR (2021) Q3, 1499/2489 Medicine (miscellaneous) No data IDR 2021 UEM

Hypertension mediated organ damage (HMOD) refers to structural or functional changes in arteries or target organs that can be present in long-standing hypertension, but it can be also found in naïve never treated patients. Traditionally, cardiovascular risk is stratified with charts or calculators that tend to underestimate the real cardiovascular risk. The diagnosis of HMOD automatically reclassifies patients to the highest level of cardiovascular risk. Subclinical HMOD can be present already at the diagnosis of hypertension and more than 25% of hypertensives are misclassified with the routine tests recommended by hypertension guidelines. Whether HMOD regression improves cardiovascular outcomes has never been investigated in randomized clinical trials and remains controversial. However, different drugs have been probed with promising results in high cardiovascular risk patients, such as the new antidiabetic or the novel non-steroid mineralocorticoid antagonists. Accordingly, trials have shown that lowering blood pressure reduces cardiovascular events. In this narrative review, we will discuss the role of HMOD in cardiovascular risk stratification, the different types of organ damage, and the evidence available to define whether HMOD can be used as a therapeutic target. El daño orgánico mediado por hipertensión (HMOD) se refiere a cambios estructurales o funcionales de larga duración en las arterias u órganos diana de la hipertensión, pero también se puede encontrar en pacientes que nunca han recibido tratamiento antihipertensivo previo. Tradicionalmente, el riesgo cardiovascular se ha estratificado utilizando tablas, calculadoras o algoritmos que tienden a subestimar el riesgo cardiovascular real. El diagnóstico del HMOD reclasifica automáticamente a los pacientes al nivel más alto de riesgo cardiovascular. El HMOD subclínico ya puede estar presente en el momento del diagnóstico de hipertensión y más del 25% de los hipertensos están mal clasificados con las pruebas de rutina recomendadas por las guías de hipertensión. Sin embargo, si la regresión del HMOD mejora los resultados cardiovasculares no suele ser un objeto de investigación en ensayos clínicos aleatorizados y sigue siendo un aspecto controvertido. A pesar de ello, se han probado diferentes fármacos con resultados prometedores en pacientes de alto riesgo cardiovascular, como los nuevos antidiabéticos o los nuevos antagonistas de mineralocorticoides no esteroides. De hecho, diferentes estudios han demostrado que bajar la presión arterial reduce los eventos cardiovasculares. En esta revisión narrativa, se discutirá el papel del HMOD en la estratificación del riesgo cardiovascular, los diferentes tipos de daño orgánico y la evidencia disponible para definir si HMOD puede usarse como un objetivo terapéutico. Sin financiación 3.084 JCR (2021) Q2, 40/90 Urology & Nephrology 0.252 SJR (2021) Q3, 49/72 Nephrology No data IDR 2021 UEM

Producción Científica, Alzheimer’s disease (AD) is a remarkable challenge for healthcare in the 21st century. Since 2017, deep learning models with transfer learning approaches have been gaining recognition in AD detection, and progression prediction by using neuroimaging biomarkers. This paper presents a systematic review of the current state of early AD detection by using deep learning models with transfer learning and neuroimaging biomarkers. Five databases were used and the results before screening report 215 studies published between 2010 and 2020. After screening, 13 studies met the inclusion criteria. We noted that the maximum accuracy achieved to date for AD classification is 98.20% by using the combination of 3D convolutional networks and local transfer learning, and that for the prognostic prediction of AD is 87.78% by using pre-trained 3D convolutional network-based architectures. The results show that transfer learning helps researchers in developing a more accurate system for the early diagnosis of AD. However, there is a need to consider some points in future research, such as improving the accuracy of the prognostic prediction of AD, exploring additional biomarkers such as tau-PET and amyloid-PET to understand highly discriminative feature representation to separate similar brain patterns, managing the size of the datasets due to the limited availability., Ministerio de Industria, Energía y Turismo (AAL-20125036)

Con el avance de la tecnología, se ha popularizado entre la población el uso de dispositivos para medir su estado de salud. Para lograr esto, se suelen utilizar dispositivos vestibles como los smartwatch y smartbands, dispositivos ambientales embebidos en los alrededores, e incluso dispositivos conectados a aplicaciones móviles. El uso de estas tecnologías también se ha popularizado entre los profesionales de la salud.Esta tesis se centra en el desarrollo de dispositivos para monitorizar la salud de adultos mayores y adultos frágiles. Se desarrollaron dos líneas de trabajo: en la primera se diseñó e implementó un sistema vestible para monitorizar en tiempo real la respiración de los usuarios; en la segunda se desarrolló un sistema ambiental capaz de medir la altura del salto vertical efectuado por los usuarios sobre él.Sistema vestible para monitorizar la respiración:- Dentro de esta línea de trabajo se investigó un nuevo sensor de respiración que venía a cubrir algunas lagunas existentes en el estado de la técnica: la integración de todos los elementos electrónicos del sistema en un encapsulado compacto, la liberación del diseño para su reutilización y mejora por parte de otros investigadores y el bajo coste de los elementos que componen el sistema, entre otros. El sistema vestible consiste en un dispositivo que se coloca alrededor del pecho mediante una cinta ajustable. Este sistema funciona mediante un sensor piezoresistivo que detecta las variaciones en el diámetro del pecho ocasionadas al inhalar y exhalar; las variaciones detectadas son enviadas de forma inalámbrica mediante Bluetooth a una estación de visualización elegida por el usuario (PC, Tablet o Smartphone). El sistema se encuentra embebido en un armazón impreso en 3D. Para validar el funcionamiento de este sistema, se realizaron pruebas con 21 voluntarios que efectuaron diferentes ritmos de respiración. Para obtener los ritmos respiratorios de cada señal generada, se utilizaron dos algoritmos. Estos algoritmos calculan el ritmo respiratorio al segmentar la señal original en ventanas de tiempo desde 6 hasta 30 segundos. Los resultados obtenidos muestran que, con una ventana de tiempo de 27 segundos, se obtiene el menor error para cada algoritmo (4,02% y 3,40 %).Sistema ambiental para medir el salto vertical:- Dentro de esta segunda línea de trabajo se investigó en un novedoso sistema ambiental para medir la altura del salto, lo que supuso una innovación respecto a los sensores utilizados actualmente para este fin. El sistema ambiental consiste en una plataforma que detecta objetos sobre ella mediante la presión, y mide el tiempo transcurrido desde que un objeto se retira y se coloca de nuevo. El sistema detecta los objetos mediante una matriz de sensores piezoresitivos (Force Sensitive Resistors - FSR realizados con velostat). Las dimensiones de la plataforma son 30 cm x 30 cm, área sobre la cual se distribuyen un total de 256 sensores FSR. El salto vertical se calcula mediante la fórmula de tiempo de vuelo, y el resultado es enviado mediante Bluetooth a un PC o Smartphone. Se realizaron dos experimentos: en el primero participaron un total de 38 voluntarios, con el objetivo de validar el funcionamiento del sistema con una cámara de alta velocidad como referencia (120 fps); en el segundo experimento se capturaron los datos en crudo de 15 voluntarios, con estos datos se emularon 10 frecuencias de muestreo (desde 20 Hz hasta 200 Hz) y se analizaron los efectos de utilizar frecuencias más bajas. Del primer experimento se obtuvo un error relativo medio de 1.98% con un coeficiente de determinación r2= 0,996. Del segundo experimento se determinó que las frecuencias de muestreo de 200 Hz y 100 Hz muestran un desempeño similar al mantener un error relativo por debajo del 5% en el 95% de las mediciones.Finalmente, este trabajo de tesis concluye indicando las principales aportaciones realizadas para cada una de las dos líneas de trabajo, así como el trabajo futuro que podría desarrollarse en cada una de ellas.

La prueba cutánea (SPT) se utiliza para diagnosticar múltiples alergias. Este método se basa en medir el tamaño de las pápulas que aparecen en la piel al exponerse a un alérgeno. No obstante, la medición manual es un proceso tedioso y es susceptible a errores inter e intraobservador. Por esta razón, se han planteado diferentes enfoques, con el fin de mejorar la reproducibilidad de la prueba. El objetivo de este trabajo es mejorar parte de la lectura automatizada de la prueba cutánea, mejorando la confiabilidad del proceso de detección de pápulas mediante el uso de redes neuronales convolucionales (CNN). El conjunto de datos está conformado por imágenes 3D de la superficie del brazo. Con estas, se entrena una CNN para detectar y segmentar las pápulas, y finalmente, se realiza un ajuste paramétrico para medir su diámetro mayor. Estos resultados son comparados con las mediciones realizadas por un médico en una interfaz, para así obtener indicadores de concordancia entre las medidas. Los resultados muestran que, a pesar de la poca cantidad de datos adquiridos, el método planteado permite realizar una detección confiable. Estos resultados podrían ser mejorados teniendo una mayor cantidad de datos para mejorar la generalización y exactitud de la segmentación de la CNN.

A 36-year-old asymptomatic woman underwent 4D-flow cardiac magnetic resonance (CMR) after an abnormality was observed on electrocardiogram (negative T-waves in V1-V3), to rule out cardiomyopathy (1.5T CMR, optima-450W-GE, 4D-flow; Gadovist gadolinium, 0.15 mmol/kg; matrix, 172 × 172; FOV, 42; VENC, 150 cm/s; bandwidth, 62.50; NEX, 4; voxel size, 2.4 × 2.4 × 2.4mm) (figure 1A-C and video 1 and video 2 of the supplementary data). This showed that the right coronary artery (RCA) had an anomalous origin from the pulmonary artery (ARCAPA), with coronary artery ectasia. Cardiac computed tomography (CT) was then performed to confirm the diagnosis and give a more precise anatomic assessment (RevolutionTM-CT256-GE, USA; contrast, Iopamidol 370 mg/mL) (figure 1D-G). Here we compare the images from the 2 techniques of this rare congenital anomaly. Sin financiación No data JCR 2021 0.385 SJR (2021) Q3, 1499/2489 Medicine (miscellaneous) No data IDR 2021 UEM

Background: Neglected Tropical Diseases (NTDs) are a major health problem that cause more than 18.79 million disability adjusted life years (DALYs) worldwide. They affect mainly the poorest populations of tropical and subtropical regions. To counter them many interventions are being conducted, notably mobile health (mHealth) interventions, such as the one launched by the World Health Organisation against skin NTDs (sNTDs), where a mobile application, Skin NTDs app, was created to act as a decision supporting tool for Frontline Health Workers (FHW). Objectives: The main objective of this protocol is to assess the quality of WHO’s Skin NTDs app as a decision supporting tool. The main objective of the pilot test is to assess the feasibility of the protocol. Design and methods: This study will be cross-sectional. The sample of the study will be obtained using respondent-driven sampling (RDS). The quantitative data will be obtained by conducting an online survey based on an existing app assessment tool named MARS, and the qualitative data, from semi-structured interviews. Then they will be analysed accordingly. Results: The pilot test revealed that the protocol was easy to follow and reproduce. The results of the survey showed that Skin NTDs app’s quality is right above average, with a total mean score of 3.74 in the objective categories, and 3.09 in the subjective quality section. Conclusions: As the protocol was found to be easy to reproduce, and given its importance for the development of Skin NTDs app, a long-term study will be performed based on it

Sin financiación 6.975 JCR (2021) Q1, 33/143 Cardiac & Cardiovascular Systems 0.407 SJR (2021) Q3, 205/356 Cardiology and Cardiovascular Medicine No data IDR 2021 UEM

La Instrumentadora SAS es una empresa comercializadora de materiales médico-quirúrgicos, se divide en varias líneas. La línea de alta tecnología se encarga del alquiler y venta de equipos biomédicos importados. El neuronavegador es un equipo que por medio de imágenes diagnósticas y reconstrucción 3D, le permite al cirujano saber dónde se encuentra la lesión y así mismo cómo abordarla, esto gracias a la correlación que existe entre la cámara infrarroja y MDR (Marco Dinámico de Referencia). Esta correlación muchas veces se ve interferida por varias razones, la más común es porque la cámara no cuenta con la altura o grados de libertad suficientes que permitan encontrar la posición ideal para no interferir con la ubicación del personal asistencial y/o de otro equipo biomédico que se encuentre en las salas quirúrgicas. Actualmente la empresa tiene un soporte móvil que no cuenta con la portabilidad de transportarse libremente, así como el material de fabricación no garantiza una correcta limpieza para llevar a un ambiente quirúrgico, cabe resaltar que no cuenta con los grados de libertad suficientes para lograr una óptima correlación MDR-cámara. Por estas razones este trabajo tiene como objetivo crear un diseño en 3D en SolidWorks, donde el soporte cuente con más articulación para la cámara, en general sea más portable, ergonómico y ligero, cuya función sea de transportar y soportar todos los accesorios del neuronavegador en una sola unidad. Para lograr esto, se implementó la metodología de diseño en donde se empezó con la identificación de necesidades, seguido de una definición del problema (especificaciones objetivo del diseño), síntesis (creación de conceptos), análisis y evaluación del prototipo. Aunque los resultados sean un diseño 3D, el software brinda un acercamiento al mundo real. El prototipo satisface todas las necesidades planteadas según la evaluación al diseño en 3D. Cabe mencionar, que este proyecto, es una primera fase a la implementación de un soporte físico, ya que la fase de optimización y construcción se ha estado evaluando con empresas expertas en el área. Este prototipo, fue diseñado al cumplimiento de varias resoluciones impuestas por el Ministerio de Protección Social., ́, Pregrado, Ingeniero(a) Biomédico(a)

La presente investigación tuvo como finalidad evaluar la influencia de la aplicación de la estrategia didáctica del Aprendizaje basado en problemas (ABP) en el desarrollo cognitivo de los estudiantes de Tecnología Médica de la asignatura de Semiología Radiográfica en la Universidad Nacional Mayor de San Marcos año 2018. Corresponde a un diseño experimental en un nivel cuasi experimental y a un enfoque cuantitativo. La recolección de datos se obtuvo de forma longitudinal luego de un pretest y postest. El procedimiento experimental de la investigación se desarrolló en la Universidad Nacional Mayor de San Marcos (UNMSM), durante las clases de la asignatura de Semiología Radiográfica durante el año 2018. La población estuvo constituida por 35 alumnos de tecnología médica que llevaban la asignatura de Semiología Radiográfica, y la muestra por 28 alumnos. (14 grupo experimental, 14 grupo control). Ambos grupos fueron evaluados con una prueba escrita (pretest). Al grupo experimental se le aplicó el ABP como estrategia didáctica, y al grupo control las estrategias habituales. Luego de dos meses se aplicó una prueba escrita (postest). Dichos resultados fueron evaluados mediante pruebas estadísticas las mismas que confirmaron que si existió influencia significativa de la ejecución del ABP para el desarrollo cognitivo en los estudiantes de tecnología médica.

Propósito: El propósito del trabajo es el diseño y evaluación, en un entorno realista, de un sistema basado en aprendizaje máquina para el diagnostico del glaucoma en centros de atención primaria, con un coste asequible y con diagnósticos interpretables. Métodos: El sistema toma como entrada datos clínicos e imágenes de fondo ocular del paciente para emitir una probabilidad de que el paciente padezca el glaucoma. La base de datos utilizada es PAPILAv1, una novedosa base de datos que contiene datos clínicos y retinografías con segmentaciones de ambos ojos de un mismo paciente. El sistema consta de tres bloques: el bloque de segmentación, el bloque de diagnostico por red convolucional y el bloque final. El bloque de segmentación toma como entrada una retinografía o Imagen del Fondo Ocular (IFO) y para esa imagen extrae las características morfológicas de la Cabecera del Nervio Óptico (CNO), tales como el CDR el ISNT y el RDR. El segundo bloque emite una probabilidad de presencia del glaucoma a partir de la región de alrededor del disco óptico en la IFO. Por último, combinando las características morfológicas, la probabilidad de glaucoma del segundo bloque y los datos clínicos, se proporciona el prediagnóstico final. Resultados: En cada uno de los tres bloques que conforman el sistema se han conseguido resultados bastante prometedores, sobre todo teniendo en cuenta la escasa cantidad de instancias en la base de datos. Para el bloque de segmentación se han conseguido una IoU 0.89 para el caso de los discos ópticos y una IoU de 0.57 para la copa óptica. En cuanto al segundo bloque se obtenido un área bajo la curva ROC (AUC) > 0.8. El resultado de la clasificación final es una AUC > 0.85, demostrando así la eficacia del sistema para el prediagnóstico en centros de atención primaria. Conclusiones: El sistema ha mostrado un rendimiento muy prometedor además de que en todo momento se puede observar las razones por las que el sistema ha tomado la decisión. Con pocos datos hablando en términos de aprendizaje máquina se conseguido automatizar un gran número de tareas y reducir así la presión asistencial e incrementar en número de pacientes atendidos. Por cada 100 pacientes sanos se etiquetarán 14 como enfermos (Falsos Positivos) y por cada 100 pacientes enfermos con glaucoma se etiquetarán 75 pacientes como tales y 25 pacientes como sanos (Falsos Negativos). A pesar de los resultados, para establecer el diagnóstico final haría falta más datos tales como la tonometría óptica, ya que el sistema no supera la barrera de 0.9 en AUC. Por ello se aconseja el uso del sistema de manera informativa con el propósito de averiguar si un paciente corre el riesgo de padecer el glaucoma. Escuela Técnica Superior de Ingeniería de Telecomunicación Universidad Politécnica de Cartagena

Background Point of care ultrasound study (POCUS) is a relatively new technique in Spanish Emergency Departments (EDs). Nonetheless, its use is increasing, and the number of emergency doctors and the number of papers published in our country has skyrocketed in last decade. Despite this fact, there is still no evidence of how POCUS is taught in our medical schools. Objective To ascertain the level of knowledge about POCUS in first year resident doctors of three hospitals in Madrid, and one year after having worked in ED with POCUS practice. Methods and study design The study looked at demographic aspects, POCUS knowledge, and opinions about its usefulness in the ED, prior to and after working in ED with routine use of POCUS. Results Of the 265 questionnaires, 197 were first-year residents (Group 1) and 68 second-year residents (Group 2). Another 55 senior medical students completed the questionnaire (Group 3). The majority of Groups 1 and 3 stated to have a very low POCUS level. Almost three-quarters (73%) of Group 2 stated having an intermediate or high level, and 26% even declared having full knowledge. More than half of the students agreed that POCUS was a useful tool in ED. Conclusions There is a low level of knowledge about POCUS among first-year residents. After working in POCUS qualified EDs, these resident doctors state both the importance and their higher level of knowledge of POCUS. Introducción La ecografía a pie de cama (EPC) es una técnica diagnóstica cada día más utilizada por los médicos urgenciólogos en los servicios de urgencias hospitalarios españoles. No obstante, desconocemos el nivel de la EPC de nuestros médicos residentes de primer año (R1). Objetivo Determinar el nivel de conocimientos sobre la EPC de los R1, en 3 hospitales universitarios de Madrid, y el conocimiento un año después de haber trabajado en servicios de urgencias con utilización habitual de la EPC. Métodos Nuestra encuesta investigaba datos demográficos, nivel previo de conocimiento de la EPC y opinión acerca de su utilidad en el servicio de urgencias. También se aplicó la encuesta a 55 estudiantes de medicina del último curso (EM6). Resultados De 265 encuestas: 197 fueron de R1 y 68 de R2. También se pasó la encuesta a otros 55 estudiantes de medicina del último curso (EM6). La mayoría de los R1 y EM6, revelaron un nivel previo muy bajo de conocimientos de la EPC. En cambio, el 73% de los R2, manifestaron un nivel intermedio o alto, e incluso un 26% declararon un conocimiento amplio. Más de la mitad de los encuestados manifestó estar de acuerdo en que la EPC era una herramienta muy útil en el servicio de urgencias. Conclusiones Existe un bajo nivel de conocimientos sobre la EPC entre los R1. Después de haber trabajado en servicios de urgencias con práctica habitual de EPC, estos mismos médicos residentes, reconocieron tanto la importancia de la EPC como su alto nivel de conocimientos de la EPC. Sin financiación No data JCR 2020 0.288 SJR (2020) Q3, 821/1544 Education 0.347 IDR (2019) C2, 78/230 Educación UEM

Objectives: To assess the usefulness of proton MR-spectroscopy (1H-MRS) and diffusion-weighted MRI (DW-MRI) sequences in the follow-up of CLL-patients with chemotherapy treatment. The monitoring of CLL-patients susceptible to chemotherapy treatment is complicated due to the difficulty in assessing the response to treatment. Chemotherapy leads to changes in bone marrow composition and these changes can be evaluated by functional MR-sequences. Methods: 23 patients diagnosed with CLL by our hospital’s Hematology Service underwent a lumbar MR prior and post-chemotherapy applying 1H-MRS and DW-MRI. The concentrations of water and lipids were quantified applying the quantification program LCModel. The Apparent Diffusion Coefficient (ADC) values were calculated with the Functool program (GE). The Wilcoxon sign test was used to compare pre and post treatment results, considering statistically significant P values lower than 0.05. Results: Responder patients decreased the ratio H2O/lipids concentration measured with 1H-MRS and increased the ADC value on DW-MRI in post-treatment studies (P

Tesis inédita presentada en la Universidad Europea de Madrid. Escuela de Doctorado e Investigación. Programa de Doctorado en Biomedicina y Ciencias de la Salud UEM

Background: Sedentary behavior has been described as a key factor for the development of multiple chronic diseases, it also has shown to contribute to the physical deterioration and has been described as an independent risk factor to premature mortality. Those negative effects could be reverted by increasing the daily physical activity, as the WHO recommends. Notwithstanding the negative effects, the quantity of population not following the WHO recommendations is alarming, especially among elderly, even more now with the mobility restrictions due to COVID-19 pandemic. Lately, taking advantage of the increased use of mobile phones technologies, new applications have been developed to monitor health aspects from smartphones. The use of those new technologies to specially increase the daily physical activity performance has been proved in the younger population, and more studies are needed to establish its utility among elderly. Objective: The aim of this study is to evaluate whether the use of step counter technologies (mHealth) reduces sedentary time in patients over 75 years. Design: This is a randomized clinical trial carried out in primary health care. Participants: The study population will include two groups of community elderly people over 75 years old. Methods: Patients will be randomly divided into two groups: group A (n= 199), where patients will be asked to use the Google Fit application or to wear a smart-watch, both used as a step counting tool; or group B (n= 199), where patients will receive educational health. Each individual will be followed for 3 months

This cross-sectional study aims to analyze the physical demands of elite beach handball players during an official competition. Nine elite female (mean age: 24.6 &plusmn, 4.0 years, body weight: 62.4 &plusmn, 4.6 kg, body height: 1.68 &plusmn, 0.059 m, training experience: 5 years, training: 6 h/week) beach handball players of the Spanish National Team were recruited for this study. A Global Positioning System was incorporated on each player&rsquo, s back to analyze their movement patterns. Speed and distance were recorded at a sampling frequency of 15 Hz, whereas acceleration was recorded at 100 Hz by means of a built-in triaxial accelerometer. The main finding of the study is that 53% of the distance travelled is done at speeds between 1.5 and 5 km/h and 30% of the distance is between 9 and 13 km/h (83% of the total distance covered), which shows the intermittent efforts that beach handball involves at high intensity, as reflected in the analysis of the internal load with 62.82 &plusmn, 14.73% of the game time above 80% of the maximum heart rate. These data help to orientate training objectives to the physical demands required by the competition in order to optimize the players&rsquo, performance.

Introducción: el agregado trióxido mineral (MTA) posee excelentes características de biocompatibilidad y capacidad de sellado. A pesar de ello, este material presenta unas limitaciones asociadas a su complejo manejo y al oscurecimiento del cemento blanco una vez fraguado. El difícil manejo se ha abordado aplicando ultrasonidos sobre el cemento recién preparado y colocado en la cavidad a sellar. En este trabajo se ha estudiado el efecto los ultrasonidos sobre el cambio de color del MTA en superficie y en profundidad. Metodología: se rellenaron 240 cavidades realizadas en discos de dentina radicular humana con Coloured ProRoot® (P), Ángelus® blanco (AB) y Ángelus® gris (AG). 120 muestras se obturaron con cada MTA de manera convencional y en las otras 120, además de la condensación convencional, se aplicó vibración con ultrasonidos. Tras 28 días, se adquirieron imágenes digitales de las muestras y se cuantificaron los cambios de reflectividad superficial de los respectivos cementos. Posteriormente, se cortaron las muestras axialmente y se tomaron imágenes digitales: al no ser homogénea la distribución de color del MTA, se describieron los patrones de textura. Resultados: el color superficial fue significativamente distinto entre AB y AG cuando se aplicaron ultrasonidos, resultando las muestras de AB preparadas con ultrasonidos más claras que las de AG. Las muestras preparadas con AG y P con ultrasonidos mostraron que las de P fueron significativamente más claras tras fraguar. En los especímenes cortados, la textura adoptada por los MTA en profundidad fue significativamente distinta entre AB y P al aplicar ultrasonidos. Cuando no se emplearon, no hubo diferencias significativas en las texturas de los MTA fraguados. Conclusión: la aplicación de ultrasonidos ayuda a mantener el color original de los MTA tras el fraguado, especialmente en AB respecto a P. Sin financiación No data 2020 UEM

Introduction The aim of this study was to evaluate the influence of rotary (ProTaper Next [PTN; Dentsply Maillefer, Ballaigues, Switzerland] and ProTaper Gold [PTG, Dentsply Maillefer]) and reciprocating (WaveOne Gold [WOG, Dentsply Maillefer]) systems in dentinal microcrack generation after the preparation of curved root canals using micro–computed tomographic analysis. Methods Twenty-four human mandibular molars with curved roots were scanned in a micro–computed tomographic device using an isotropic resolution of 6.78 μm and randomly assigned into 1 of 3 experimental groups (n = 8) according to the root canal instrumentation system used (PTN, PTG, or WOG). Then, the root canals were prepared up to PTN X2, PTG F2, and WOG Primary instruments in the PTN, PTG, and WOG groups, respectively. After canal preparation, each specimen was scanned again. Pre- and postoperative cross-sectional images of the roots (N = 35,304) were analyzed to identify the presence of dentinal microcracks. Results Overall, 26% of the images presented dentinal defects (n = 9188). Dentinal microcracks were observed in 24.6%, 26%, and 27.4% of the postinstrumentation images from the PTN, PTG, and WOG groups, respectively. However, all of these dentinal microcracks were already present in the corresponding preoperative images. No new microcracks were generated after the preparation of curved root canals of mandibular molars using the aforementioned systems. Conclusions Root canal instrumentation with PTN, PTG, and WOG systems did not induce the formation of new dentinal microcracks. Sin financiación 4.4422 JCR (2021) Q1, 13/92 Dentistry, Oral Surgery & Medicine 1.599 SJR (2021) Q1, 4/142 Dentistry (miscellaneous) No data IDR 2021 UEM

Este documento presenta el desarrollo e implementación de 2 aplicaciones en el entorno de Visual Basic para el apoyo en los procesos de evaluación de desempeño y gestión de mantenimientos preventivos en el hospital San Ignacio, This document presents the develpment and implementation of 2 applications in the Visual Basic environment to support the processes of performance evaluation and maintenance management of biomedical equipment at Hospital San Ignacio, El documento 1 presenta información adicional al proyecto presentado con respecto a las diferentes ventas desarrolladas, Pregrado, Ingeniero(a) Biomédico(a)

Sin financiación No data 2021 UEM

Dental biofilm plays a very crucial role in the etiopathogenesis of periodontal andperi-implant diseases. Over the past decade, tremendous research has been carried outto know the structure of biofilm and the mechanism by which it causes the destruction of supporting tissues of tooth or implant. Periodontal or peri-implant therapy usually begins with primarily removing thebiofilm and is considered as non-surgical mechanical debridement. Although scaling and root planing (SRP) is regarded as a gold standard for mechanical plaque debridement, various other means of biofilm removal have constantly been evolving. These may vary from different scaling systems such as vector systems to decontamination of pockets with LASER therapy. Nowadays, a new concept has emerged known as "guided biofilm therapy" (GBT). It is beneficial in removing the biofilm around the tooth and implant structures, resulting in better or comparable clinical outcomes than SRP. These results were substantiated with the reduction in the microbial load as well as the reduction in the inflammatory cytokines. This review will highlight the various aspects of GBT used in periodontal and peri-implant disease. Sin financiación 4.926 JCR (2021) Q2, 54/136 Microbiology 0.862 SJR (2021) Q2, 58/156 Microbiology No data IDR 2021 UEM

The high prevalence of falls and the enormous impact they have on the elderly population is a cause for concern. We aimed to develop a walking-monitor gait pattern (G-STRIDE) for older adults based on a 6-axis inertial measurement (IMU) with the application of pedestrian dead reckoning algorithms and tested its structural and clinical validity. A cross-sectional case–control study was conducted with 21 participants (11 fallers and 10 non-fallers). We measured gait using an IMU attached to the foot while participants walked around different grounds (indoor flooring, outdoor floor, asphalt, etc.). The G-STRIDE consisted of a portable inertial device that monitored the gait pattern and a mobile app for telematic clinical analysis. G-STRIDE made it possible to measure gait parameters under normal living conditions when walking without assessing the patient in the outpatient clinic. Moreover, we verified concurrent validity with convectional outcome measures using intraclass correlation coefficients (ICCs) and analyzed the differences between participants. G-STRIDE showed high estimation accuracy for the walking speed of the elderly and good concurrent validity compared to conventional measures (ICC = 0.69, p &lt, 0.000). In conclusion, the developed inertial-based G-STRIDE can accurately classify older people with risk to fall with a significance as high as using traditional but more subjective clinical methods (gait speed, Timed Up and Go Test).

Este estudio tuvo como objetivo explorar el impacto del entrenamiento con electroestimulación integral (WB-EMS) en la fuerza máxima y explosiva de mujeres físicamente activas y con experiencia en entrenamiento de fuerza. Participaron en el estudio diez mujeres con experiencia en entrenamiento. Realizaron entrenamiento de fuerza durante 6 semanas asignadas al azar al grupo control o WB-EMS. Las participantes realizaron dos sesiones de entrenamiento por semana, consistiendo en press de banca, remo, peso muerto y sentadilla con una carga del 85% de la repetición máxima (1RM), y usaron un transductor de posición lineal para monitorizar la velocidad de movimiento deteniendo el ejercicio cuando la velocidad bajó un 10%. La frecuencia de electroestimulación se estableció en 85Hz, el pulso fue de 350µs y tipo de pulso de onda rectangular bipolar. Los datos mostraron que la fuerza máxima, la velocidad máxima y el número máximo de repeticiones bajo una carga específica aumentaron significativamente (P≤0.05) en press de banca, sentadilla, remo y peso muerto en el grupo de entrenamiento con WB-EMS en comparación con el grupo control. Además, el rendimiento de salto en salto squat (SJ), salto con contra movimiento (CMJ) y salto Abalakov (ABK) fue significativamente mayor en comparación con el grupo control (P≤0.01). Podemos concluir que el entrenamiento de fuerza con WB-EMS durante 6 semanas mejoró la fuerza máxima y explosiva de mujeres físicamente activas y con experiencia en entrenamiento de fuerza, en comparación con el grupo control. This study aimed to explore the impact of whole body electromyostimulation training (WB-EMS) on the maximum strength and explosive power of physically active and experienced in strength training women. Ten females with a sport training background participated in the study. They performed strength training for 6 weeks randomly assigned to either WB-EMS group or control group. Participants performed two training sessions per week, consisted in bench press, rowing, deadlift and squat with a load of 85% one repetition maximum (1RM), and using a linear position transducer to monitor the movement velocity to stop exercise when velocity dropped 10%. WB-EMS frequency was set at 85 Hz, pulse 350 µs, and bipolar rectangular wave pulse type. Data showed that the maximum strength, maximum velocity and maximum number of repetitions under a specific load were significantly increased (P≤0.05) in bench press, squat, rowing and deadlift in the WB-EMS group compare to the control group. Also, Squat Jump (SJ), Counter Movement Jump (CMJ) and Abalakov Jump (ABK) jumping performance was significantly greater compared to control group (P≤0.01). We can conclude that WB-EMS strength training for 6 weeks enhanced physically active and experienced in strength training women’s maximum and explosive strength compare to control. Sin financiación No data JCR 2020 No data SJR 2020 0.321 IDR (2020) C3, 25/43 Deporte UEM

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Sin financiación 4.872 JCR (2020) Q2, 18/64 Respiratory System 0.262 SJR (2021) Q3, 102/144 Pulmonary and Respiratory Medicine No data IDR 2020 UEM

Ventilator-induced diaphragm dysfunction (VIDD) is increasingly recognized as an important side-effect of invasive ventilation in critically ill patients and is associated with poor outcomes. Whether patients with VIDD benefit from temporary diaphragm pacing is uncertain. Intramuscular diaphragmatic electrodes were implanted for temporary stimulation with a pacing device (TransAeris System) in two patients with VIDD. The electrodes were implanted via laparoscopy (first patient) or via bilateral thoracoscopy (second patient). Stimulation parameters were titrated according to tolerance. Diaphragm thickening fraction by ultrasound, maximum inspiratory pressure (Pimax) and diaphragm electromyography (EMGdi) signal analysis were used to monitor the response to diaphragm pacing. Both patients tolerated diaphragm pacing. In the first patient, improvements in diaphragm excursions were noted once pacing was initiated and diaphragm thickening fraction did not further deteriorate over time. The diaphragm thickening fraction improved in the second patient, and Pimax as well as EMGdi analysis suggested improved muscle function. This patient could be fully weaned from the ventilator. These case reports present the first experience with temporary diaphragm pacing in critically ill patients with VIDD. Our results should be taken cautiously given the reduced sample size, but provide the proof of concept to put forward the hypothesis that a course of diaphragm pacing may be associated with improved diaphragmatic function. Our findings of the tolerance to the procedure and the beneficial physiological effects are not prove of safety and efficacy, but may set the ground to design and conduct larger studies.NEW & NOTEWORTHY Diaphragmatic electrode implantation and temporary diaphragm pacing have not been previously used in ICU patients with VIDD. Patients were monitored using a multimodal monitoring approach including ultrasound of the diaphragm, measurement of maximum inspiratory pressure and EMG signal analysis. Our results suggest that diaphragm pacing may improve diaphragmatic function, with the potential to prevent and treat VIDD in critically ill patients. Safety and efficacy of this intervention is yet to be proven in larger studies. Sin financiación 3.881 JCR (2021) Q2, 27/81 Physiology 1.003 SJR (2021) Q1, 475/2489 Medicine (miscellaneous) No data IDR 2021 UEM

Para las entidades prestadoras de salud, es indispensable el desarrollo de actividades programadas tales como son los mantenimientos preventivos y las calibraciones. Estas actividades, tienen como finalidad principal evitar adversidades al momento de hacer uso de la tecnología, pero también son de importancia realizarlas para que el tiempo de vida útil de los equipos no disminuya. Dentro de dichas actividades programadas, se evalúa el correcto funcionamiento del equipo biomédico y también se realizan cambios predictivos de algunos componentes del equipo los cuales pueden presentar fallas durante el uso de la tecnología en un futuro cercano. Así mismo, es de importancia incentivar el correcto uso de las tecnologías por parte del personal clínico para evitar fallos de la tecnología durante su uso y con esto evitar accidentes, para el paciente o para el personal que está manipulando el dispositivo. En el Hospital Universitario Mayor de Méderi y el Hospital Universitario Barrios Unidos, la tecnología biomédica es considerada un eje fundamental para la atención de la salud, es por esto que el realizar las actividades programadas de forma oportuna, es de gran importancia para la institución. Por este motivo, se propone diseñar una herramienta de escritorio para realizar la gestión de las actividades programadas de los equipos comúnmente usados dentro de la institución teniendo en cuenta que esta era la necesidad que el departamento de ingeniería biomédica requería solucionar. Esta herramienta se realizó por medio de software de Excel, más específicamente de la herramienta Visual Basic, la cual permitió realizar una interfaz de usuario dirigida al personal encargado de realizar el mantenimiento de las diferentes tecnologías de la institución y al personal de la salud que hace uso de estas mismas. La interfaz permite guardar y mostrar información de las actividades programadas, esta información es proveniente de los manuales de servicio para cada equipo biomédico. El uso de la interfaz puede generar un impacto positivo para el personal de mantenimiento al momento de realizar las actividades programadas de los equipos médicos y para el personal de salud para un correcto uso de la tecnología., For health care providers, it is essential to develop programmed activities such as preventive maintenance and activities such as preventive maintenance and calibrations are indispensable for health calibrations. The main purpose of these activities is to avoid adversities at the time of using the technology, but they are also important to carry them out in order to the use of technology, but it is also important to carry them out so that the useful life of the equipment does not that the useful life of the equipment does not decrease. Within these programmed activities, the correct the correct functioning of the biomedical equipment is evaluated and also predictive changes of some components of the predictive changes of some components of the equipment, which may fail during the use of the equipment components that may fail during the use of the technology in the near future. Likewise, it is of to encourage the correct use of the technologies by the clinical staff in order to avoid technology failures during its use. to avoid failures of the technology during its use and thus avoid accidents, for the patient or for the personnel who are for the patient or for the personnel handling the device. At the Hospital Universitario Mayor de Méderi and the Hospital Universitario Barrios Hospital Universitario Barrios Unidos, biomedical technology is considered a fundamental axis for health care. health care, which is why performing scheduled activities in a timely manner is of great importance for the institution. is of great importance for the institution. For this reason, it is proposed to design a desktop tool to to perform the management of scheduled activities of the equipment commonly used within the institution commonly used within the institution, taking into account that this was the need that the department of biomedical engineering that the biomedical engineering department needed to solve. This tool was made by means of Excel software, more specifically, the Visual Basic tool, which Visual Basic tool, which allowed the creation of a user interface directed to the personnel in charge of the personnel in charge of the maintenance of the different technologies of the institution and the health institution and to the health personnel who use these technologies. The interface allows to information of the programmed activities, this information is taken from the service manuals for the This information comes from the service manuals for each biomedical equipment. The use of the interface can generate a positive impact for the maintenance personnel when performing the programmed activities. maintenance personnel when performing the scheduled activities of the medical equipment and for the healthcare and for the health personnel for a correct use of the technology., Pregrado, Ingeniero(a) Biomédico(a)