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301 results on '"Tazaki, Hiroshi"'

152. CLNICAL APPLICATION OF FLOW CYTOMETRY IN UROLOGY

Author

Tachibana, Masaaki, primary, Nakamura, Soh, additional, Shibayama, Taro, additional, Jitsukawa, Seido, additional, Deguchi, Nobuhiro, additional, Baba, Shiro, additional, Nakazono, Masaaki, additional, Hata, Makoto, additional, and Tazaki, Hiroshi, additional

Published
1986
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155. CLINICAL STUDY ON VESICOURETERAL REFLUX

Author

Hata, Makoto, primary, Kinoshita, Hidechika, additional, Hayakawa, Masamichi, additional, Tadokoro, Shigeru, additional, Ieda, Kazuo, additional, Ishikawa, Hiromichi, additional, Hatano, Tadashi, additional, Fujioka, Toshio, additional, Jitsukawa, Seido, additional, Murai, Masaru, additional, and Tazaki, Hiroshi, additional

Published
1979
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160. PHA INDUCED CYTOTOXICITY

Author

Hata, Makoto, primary, Aoki, Seiichi, additional, Jitsukawa, Seido, additional, Yoshida, Toshiko, additional, Tazaki, Hiroshi, additional, and Morizane, Toshio, additional

Published
1977
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163. CLINICAL OBSERVATION OF UROLITHIASIS

Author

Matsushita, Kazuo, primary, Ishikawa, Hiromichi, additional, Sasaki, Mitsunobu, additional, Shinoda, Masayuki, additional, Nagakura, Kazuhiko, additional, Koyama, Yuzo, additional, Tachibana, Masaaki, additional, Murai, Masaru, additional, Jitsukawa, Masamichi, additional, Nakazono, Masaaki, additional, Hata, Makoto, additional, Tazaki, Hiroshi, additional, and Kinoshita, Hidechika, additional

Published
1982
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166. Hemoperfusion for the treatment of hepatic failure

Author

Tadokoro, Shigeru, primary, Murai, Masaru, additional, Tazaki, Hiroshi, additional, Suzuki, Hiroko, additional, Nagahama, Shusaku, additional, Wada, Takao, additional, Ozawa, Yukio, additional, Hashimoto, Hiroaki, additional, and Hata, Makoto, additional

Published
1983
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168. Latent hypernephroma.

Author

JITSUKAWA, SEIDO, primary, DEGUCHI, NOBUHIRO, additional, BABA, SHIRO, additional, MURAI, MASARU, additional, NAKAZONO, MASAAKI, additional, and TAZAKI, HIROSHI, additional

Published
1984
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174. RENOVASCULAR HYPERTENSION

Author

Hata, Makoto, primary, Jitsukawa, Seido, additional, Murai, Masaru, additional, Tazaki, Hiroshi, additional, Nakamura, Hiroshi, additional, and Baba, Shiro, additional

Published
1978
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179. CLINICAL APPLICATION OF FLOW CYTOMETRY IN UROLOGY

Author

Tachibana, Masaaki, primary, Jitsukawa, Seido, additional, Iigaya, Tomohiko, additional, Nakai, Hideo, additional, Deguchi, Nobuhiro, additional, Baba, Shiro, additional, Nakazono, Masaaki, additional, Hata, Makoto, additional, and Tazaki, Hiroshi, additional

Published
1987
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180. FLUID ABSORPTION DURING PERCUTANEOUS ULTRASONIC NEPHROLITHOTRIPSY

Author

Baba, Shiro, primary, Marumo, Ken, additional, Hasegawa, Shintaro, additional, Tanoguchi, Hitoshi, additional, Tsukamoto, Takuji, additional, Ohashi, Masakazu, additional, Nakajima, Yosuke, additional, Nakamura, Kaoru, additional, Nakazono, Masaaki, additional, Deguchi, Nobuhiro, additional, Murai, Masaru, additional, Jitsukawa, Seido, additional, and Tazaki, Hiroshi, additional

Published
1985
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195. Chemosensitization of Carmustine with Maitake β-Glucan on Androgen-Independent Prostatic Cancer Cells: Involvement of Glyoxalase I.

Author

Finkelstein, Michael P., Aynehchi, Shahrad, Samadi, Albert A., Drinis, Sophia, Choudhury, Muhammad S., Tazaki, Hiroshi, and Konno, Sensuke

Subjects
*PROSTATE cancer, *CANCER chemotherapy, *CANCER cells
Abstract

Objective: To improve the poor efficacy (< 10%) of chemotherapy for patients with hormone-refractory prostate cancer, we investigated a possible cytotoxic effect of carmustine/β-glucan combination on prostatic cancer PC-3 cells, focusing on a glutathione-dependent detoxifying enzyme, glyoxalase I (Gly-I). Methods: Carmustine (BCNU) is an anticancer agent and a putative inhibitor of Gly-I, while β-glucan is a unique, nontoxic polysaccharide extracted from maitake mushrooms. The cytotoxic effects of BCNU or other anticancer agents with β-glucan on PC-3 cells were assessed by cell-viability testing and Gly-I activity was measured using the spectrophotometric method. Results: BCNU, 5-fluorouracil (5-FU), and methotrexate (MTX) were capable of inducing approximately a 50% reduction in cell viability at 72 hours, while etoposide, cisplatin, and mitomycin C were all ineffective. Only the combination of BCNU (50 μmol) and β-glucan (60 μg/mL) exhibited an enhanced cytotoxicity with an approximate 90% cell viability reduction, but little improvement was seen with any combinations of 5-FU, MTX, or β-glucon. Gly-I assays revealed that such a profound (~90%) cell death was accompanied by an approximate 80% reduction in Gly-I activity by 6 hours. Conclusion: This study demonstrates a sensitized cytotoxic effect of BCNU with β-glucan in PC-3 cells, which was associated with a drastic (~80%) inactivation of Gly-I. Therefore, the BCNU/β-glucan combination may help to improve current treatment efficacy by targeting Gly-I, which appears to be critically involved in prostate cancer viability. [ABSTRACT FROM AUTHOR]

Published
2002
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