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152. B cell sub-types following acute malaria and associations with clinical immunity

Author

Sullivan, Richard, Ssewanyana, Isaac, Wamala, Samuel, Nankya, Felistas, Jagannathan, Prasanna, Tappero, Jordan, Mayanja-Kizza, Harriet, Muhindo, Mary, Arinaitwe, Emmanuel, Kamya, Moses, Dorsey, Grant, Feeney, Margaret, Riley, Eleanor, Drakeley, Chris, Greenhouse, Bryan, Sullivan, Richard, Ssewanyana, Isaac, Wamala, Samuel, Nankya, Felistas, Jagannathan, Prasanna, Tappero, Jordan, Mayanja-Kizza, Harriet, Muhindo, Mary, Arinaitwe, Emmanuel, Kamya, Moses, Dorsey, Grant, Feeney, Margaret, Riley, Eleanor, Drakeley, Chris, and Greenhouse, Bryan

Abstract

Background Repeated exposure to Plasmodium falciparum is associated with perturbations in B cell sub-set homeostasis, including expansion atypical memory B cells. However, B cell perturbations immediately following acute malaria infection have been poorly characterized, especially with regard to their relationship with immunity to malaria. Methods To better understand the kinetics of B cell sub-sets following malaria, the proportions of six B cell sub-sets were assessed at five time points following acute malaria in four to 5 years old children living in a high transmission region of Uganda. B cell sub-set kinetics were compared with measures of clinical immunity to malaria—lower parasite density at the time of malaria diagnosis and recent asymptomatic parasitaemia. Results Atypical memory B cell and transitional B cell proportions increased following malaria. In contrast, plasmablast proportions were highest at the time of malaria diagnosis and rapidly declined following treatment. Increased proportions of atypical memory B cells were associated with greater immunity to malaria, whereas increased proportions of transitional B cells were associated with evidence of less immunity to malaria. Conclusions These findings highlight the dynamic changes in multiple B cell sub-sets following acute, uncomplicated malaria, and how these sub-sets are associated with developing immunity to malaria.

Published
2016

157. Erratum to: B cell sub-types following acute malaria and associations with clinical immunity

Author

Sullivan, Richard T., primary, Ssewanyana, Isaac, additional, Wamala, Samuel, additional, Nankya, Felistas, additional, Jagannathan, Prasanna, additional, Tappero, Jordan W., additional, Mayanja-Kizza, Harriet, additional, Muhindo, Mary K., additional, Arinaitwe, Emmanuel, additional, Kamya, Moses, additional, Dorsey, Grant, additional, Feeney, Margaret E., additional, Riley, Eleanor M., additional, Drakeley, Chris J., additional, and Greenhouse, Bryan, additional

Published
2016
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158. B cell sub-types following acute malaria and associations with clinical immunity

Author

Sullivan, Richard T., primary, Ssewanyana, Isaac, additional, Wamala, Samuel, additional, Nankya, Felistas, additional, Jagannathan, Prasanna, additional, Tappero, Jordan W., additional, Mayanja-Kizza, Harriet, additional, Muhindo, Mary K., additional, Arinaitwe, Emmanuel, additional, Kamya, Moses, additional, Dorsey, Grant, additional, Feeney, Margaret E., additional, Riley, Eleanor M., additional, Drakeley, Chris J., additional, and Greenhouse, Bryan, additional

Published
2016
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160. US Centers for Disease Control and Prevention and Its Partners' Contributions to Global Health Security.

Author

Tappero, Jordan W., Cassell, Cynthia H., Bunnell, Rebecca E., Angulo, Frederick J., Craig, Allen, Pesik, Nicki, Dahl, Benjamin A., Ijaz, Kashef, Jafari, Hamid, and Martin, Rebecca

Subjects
*WORLD health, *LEGAL compliance, *PREVENTION of communicable diseases, *PREVENTIVE medicine
Abstract

To achieve compliance with the revised World Health Organization International Health Regulations (IHR 2005), countries must be able to rapidly prevent, detect, and respond to public health threats. Most nations, however, remain unprepared to manage and control complex health emergencies, whether due to natural disasters, emerging infectious disease outbreaks, or the inadvertent or intentional release of highly pathogenic organisms. The US Centers for Disease Control and Prevention (CDC) works with countries and partners to build and strengthen global health security preparedness so they can quickly respond to public health crises. This report highlights selected CDC global health protection platform accomplishments that help mitigate global health threats and build core, cross-cutting capacity to identify and contain disease outbreaks at their source. CDC contributions support country efforts to achieve IHR 2005 compliance, contribute to the international framework for countering infectious disease crises, and enhance health security for Americans and populations around the world. [ABSTRACT FROM AUTHOR]

Published
2017
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161. Joint External Evaluation--Development and Scale-Up of Global Multisectoral Health Capacity Evaluation Process.

Author

Bell, Elizabeth, Tappero, Jordan W., Ijaz, Kashef, Bartee, Maureen, Fernandez, Jose, Burris, Hannah, Sliter, Karen, Nikkari, Simo, Chunong, Stella, Rodier, Guenael, and Jafari, Hamid

Subjects
*WORLD health, *INTERNATIONAL cooperation on public health, *NATIONAL health services, *PUBLIC health
Abstract

The Joint External Evaluation (JEE), a consolidation of the World Health Organization (WHO) International Health Regulations 2005 (IHR 2005) Monitoring and Evaluation Framework and the Global Health Security Agenda country assessment tool, is an objective, voluntary, independent peer-to-peer multisectoral assessment of a country's health security preparedness and response capacity across 19 IHR technical areas. WHO approved the standardized JEE tool in February 2016. The JEE process is wholly transparent; countries request a JEE and are encouraged to make its findings public. Donors (e.g., member states, public and private partners, and other public health institutions) can support countries in addressing identified JEE gaps, and implementing country-led national action plans for health security. Through July 2017, 52 JEEs were completed, and 25 more countries were scheduled across WHO's 6 regions. JEEs facilitate progress toward IHR 2005 implementation, thereby building trust and mutual accountability among countries to detect and respond to public health threats. [ABSTRACT FROM AUTHOR]

Published
2017
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162. Contributions of the US Centers for Disease Control and Prevention in Implementing the Global Health Security Agenda in 17 Partner Countries.

Author

Fitzmaurice, Arthur G., Mahar, Michael, Moriarty, Leah F., Bartee, Maureen, Hirai, Mitsuaki, Wenshu Li, Gerber, A. Russell, Tappero, Jordan W., and Bunnell, Rebecca

Subjects
WORLD health, INTERNATIONAL cooperation on public health, NATIONAL health services, PUBLIC health surveillance
Abstract

The Global Health Security Agenda (GHSA), a partnership of nations, international organizations, and civil society, was launched in 2014 with a mission to build countries' capacities to respond to infectious disease threats and to foster global compliance with the International Health Regulations (IHR 2005). The US Centers for Disease Control and Prevention (CDC) assists partner nations to improve IHR 2005 capacities and achieve GHSA targets. To assess progress through these CDC-supported efforts, we analyzed country activity reports dating from April 2015 through March 2017. Our analysis shows that CDC helped 17 Phase I countries achieve 675 major GHSA accomplishments, particularly in the cross-cutting areas of public health surveillance, laboratory systems, workforce development, and emergency response management. CDC's engagement has been critical to these accomplishments, but sustained support is needed until countries attain IHR 2005 capacities, thereby fostering national and regional health protection and ensuring a world safer and more secure from global health threats. [ABSTRACT FROM AUTHOR]

Published
2017
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163. Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria

Author

Boyle, Michelle J., primary, Jagannathan, Prasanna, additional, Farrington, Lila A., additional, Eccles-James, Ijeoma, additional, Wamala, Samuel, additional, McIntyre, Tara I, additional, Vance, Hilary M., additional, Bowen, Katherine, additional, Nankya, Felistas, additional, Auma, Ann, additional, Nalubega, Mayimuna, additional, Sikyomu, Esther, additional, Naluwu, Kate, additional, Rek, John, additional, Katureebe, Agaba, additional, Bigira, Victor, additional, Kapisi, James, additional, Tappero, Jordan, additional, Muhindo, Mary K, additional, Greenhouse, Bryan, additional, Arinaitwe, Emmanuel, additional, Dorsey, Grant, additional, Kamya, Moses R., additional, and Feeney, Margaret E., additional

Published
2015
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164. The Spatial Distribution of Ebola Virus Disease (EVD) Cases in Liberia Using the National Surveillance Database—March–September, 2014

Author

Merrill, Rebecca, primary, Bawo, Luke, additional, Mulbah, J. Mike, additional, Gbanyan, Stephen, additional, Mcnamara, Lucy, additional, Reaves, Erik, additional, Idowu, Rachel, additional, Christie, Athalia, additional, Neatherlin, John, additional, Tappero, Jordan, additional, Kinkade, Carl, additional, and Montgomery, Joel, additional

Published
2015
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165. Dengue Virus Infections among Haitian and Expatriate Non-governmental Organization Workers — Léogane and Port-au-Prince, Haiti, 2012

Author

Salyer, Stephanie J., primary, Ellis, Esther M., additional, Salomon, Corvil, additional, Bron, Christophe, additional, Juin, Stanley, additional, Hemme, Ryan R., additional, Hunsperger, Elizabeth, additional, Jentes, Emily S., additional, Magloire, Roc, additional, Tomashek, Kay M., additional, Desormeaux, Anne Marie, additional, Muñoz-Jordán, Jorge L., additional, Etienne, Lesly, additional, Beltran, Manuela, additional, Sharp, Tyler M., additional, Moffett, Daphne, additional, Tappero, Jordan, additional, Margolis, Harold S., additional, and Katz, Mark A., additional

Published
2014
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166. Loss and dysfunction of Vδ2+γδ T cells are associated with clinical tolerance to malaria

Author

Jagannathan, Prasanna, primary, Kim, Charlie C., additional, Greenhouse, Bryan, additional, Nankya, Felistas, additional, Bowen, Katherine, additional, Eccles-James, Ijeoma, additional, Muhindo, Mary K., additional, Arinaitwe, Emmanuel, additional, Tappero, Jordan W., additional, Kamya, Moses R., additional, Dorsey, Grant, additional, and Feeney, Margaret E., additional

Published
2014
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167. First Confirmed Cases of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection in the United States, Updated Information on the Epidemiology of MERS-CoV Infection, and Guidance for the Public, Clinicians, and Public Health Authorities—May 2014

Author

Bialek, Stephanie R., primary, Allen, Donna, additional, Alvarado-Ramy, Francisco, additional, Arthur, Ray, additional, Balajee, Arunmozhi, additional, Bell, David, additional, Best, Susan, additional, Blackmore, Carina, additional, Breakwell, Lucy, additional, Cannons, Andrew, additional, Brown, Clive, additional, Cetron, Martin, additional, Chea, Nora, additional, Chommanard, Christina, additional, Cohen, Nicole, additional, Conover, Craig, additional, Crespo, Antonio, additional, Creviston, Jeanean, additional, Curns, Aaron T., additional, Dahl, Rebecca, additional, Dearth, Stephanie, additional, DeMaria, Alfred, additional, Echols, Fred, additional, Erdman, Dean D., additional, Feikin, Daniel, additional, Frias, Mabel, additional, Gerber, Susan I., additional, Gulati, Reena, additional, Hale, Christa, additional, Haynes, Lia M., additional, Heberlein-Larson, Lea, additional, Holton, Kelly, additional, Ijaz, Kashef, additional, Kapoor, Minal, additional, Kohl, Katrin, additional, Kuhar, David T., additional, Kumar, Alan M., additional, Kundich, Marianne, additional, Lippold, Susan, additional, Liu, Lixia, additional, Lovchik, Judith C., additional, Madoff, Larry, additional, Martell, Sandra, additional, Matthews, Sarah, additional, Moore, Jessica, additional, Murray, Linda R., additional, Onofrey, Shauna, additional, Pallansch, Mark A., additional, Pesik, Nicki, additional, Pham, Huong, additional, Pillai, Satish, additional, Pontones, Pam, additional, Pringle, Kimberly, additional, Pritchard, Scott, additional, Rasmussen, Sonja, additional, Richards, Shawn, additional, Sandoval, Michelle, additional, Schneider, Eileen, additional, Schuchat, Anne, additional, Sheedy, Kristine, additional, Sherin, Kevin, additional, Swerdlow, David L., additional, Tappero, Jordan W., additional, Vernon, Michael O., additional, Watkins, Sharon, additional, and Watson, John, additional

Published
2014
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168. Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda

Author

Nankoberanyi, Sheila, primary, Mbogo, George W, additional, LeClair, Norbert P, additional, Conrad, Melissa D, additional, Tumwebaze, Patrick, additional, Tukwasibwe, Stephen, additional, Kamya, Moses R, additional, Tappero, Jordan, additional, Nsobya, Samuel L, additional, and Rosenthal, Philip J, additional

Published
2014
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169. Early parasite clearance following artemisinin-based combination therapy among Ugandan children with uncomplicated Plasmodium falciparum malaria

Author

Muhindo, Mary K, primary, Kakuru, Abel, additional, Jagannathan, Prasanna, additional, Talisuna, Ambrose, additional, Osilo, Emmanuel, additional, Orukan, Francis, additional, Arinaitwe, Emmanuel, additional, Tappero, Jordan W, additional, Kaharuza, Frank, additional, Kamya, Moses R, additional, and Dorsey, Grant, additional

Published
2014
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170. Cholera Elimination in Hispaniola

Author

Etienne, Carissa F., primary, Tappero, Jordan W., additional, Marston, Barbara J., additional, Frieden, Thomas R., additional, Kenyon, Thomas A., additional, and Andrus, Jon K., additional

Published
2013
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172. The Effects of ACT Treatment and TS Prophylaxis on Plasmodium falciparum Gametocytemia in a Cohort of Young Ugandan Children

Author

Kakuru, Abel, primary, Arinaitwe, Emmanuel, additional, Homsy, Jaco, additional, Tappero, Jordan W., additional, Muhindo, Mary, additional, Dorsey, Grant, additional, Jagannathan, Prasanna, additional, Kamya, Moses R., additional, Osilo, Emmanuel, additional, Bigira, Victor, additional, and Wanzira, Humphrey, additional

Published
2013
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174. Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria.

Author

Tchaparian, Eskouhie, Sambol, Nancy C., Arinaitwe, Emmanuel, McCormack, Shelley A., Bigira, Victor, Wanzira, Humphrey, Muhindo, Mary, Creek, Darren J., Sukumar, Nitin, Blessborn, Daniel, Tappero, Jordan W., Kakuru, Abel, Bergqvist, Yngve, Aweeka, Francesca T., and Parikh, Sunil

Subjects
PHARMACOKINETICS, PHARMACODYNAMICS, TRIMETHOPRIM, MALARIA treatment, ANTIMALARIALS, PARASITEMIA
Abstract

Background: The pharmacokinetics and pharmacodynamics of lumefantrine, a component of the most widely used treatment for malaria, artemether-lumefantrine, has not been adequately characterized in young children.Methods: Capillary whole-blood lumefantrine concentration and treatment outcomes were determined in 105 Ugandan children, ages 6 months to 2 years, who were treated for 249 episodes of Plasmodium falciparum malaria with artemether-lumefantrine.Results: Population pharmacokinetics for lumefantrine used a 2-compartment open model with first-order absorption. Age had a significant positive correlation with bioavailability in a model that included allometric scaling. Children not receiving trimethoprim-sulfamethoxazole with capillary whole blood concentrations <200 ng/mL had a 3-fold higher hazard of 28-day recurrent parasitemia, compared with those with concentrations >200 ng/mL (P = .0007). However, for children receiving trimethoprim-sulfamethoxazole, the risk of recurrent parasitemia did not differ significantly on the basis of this threshold. Day 3 concentrations were a stronger predictor of 28-day recurrence than day 7 concentrations.Conclusions: We demonstrate that age, in addition to weight, is a determinant of lumefantrine exposure, and in the absence of trimethoprim-sulfamethoxazole, lumefantrine exposure is a determinant of recurrent parasitemia. Exposure levels in children aged 6 months to 2 years was generally lower than levels published for older children and adults. Further refinement of artemether-lumefantrine dosing to improve exposure in infants and very young children may be warranted. [ABSTRACT FROM AUTHOR]

Published
2016
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175. Quantifying Heterogeneous Malaria Exposure and Clinical Protection in a Cohort of Ugandan Children.

Author

Rodriguez-Barraquer, Isabel, Arinaitwe, Emmanuel, Jagannathan, Prasanna, Boyle, Michelle J., Tappero, Jordan, Muhindo, Mary, Kamya, Moses R., Dorsey, Grant, Drakeley, Chris, Ssewanyana, Isaac, Smith, David L., and Greenhouse, Bryan

Subjects
PROTOZOAN diseases, MALARIA, AIDS in children, AIDS, AIDS patients, LONGITUDINAL method, PROTOZOA, RISK assessment, STATISTICAL sampling, RANDOMIZED controlled trials
Abstract

Background: Plasmodium falciparum malaria remains a leading cause of childhood morbidity and mortality. There are important gaps in our understanding of the factors driving the development of antimalaria immunity as a function of age and exposure.Methods: We used data from a cohort of 93 children participating in a clinical trial in Tororo, Uganda, an area of very high exposure to P. falciparum We jointly quantified individual heterogeneity in the risk of infection and the development of immunity against infection and clinical disease.Results: Results showed significant heterogeneity in the hazard of infection and independent effects of age and cumulative number of infections on the risk of infection and disease. The risk of developing clinical malaria upon infection decreased on average by 6% (95% confidence interval [CI], 0%-12%) for each additional year of age and by 2% (95% CI, 1%-3%) for each additional prior infection. Children randomly assigned to receive dihydroartemisinin-piperaquine for treatment appeared to develop immunity more slowly than those receiving artemether-lumefantrine.Conclusions: Heterogeneity in P. falciparum exposure and immunity can be independently evaluated using detailed longitudinal studies. Improved understanding of the factors driving immunity will provide key information to anticipate the impact of malaria-control interventions and to understand the mechanisms of clinical immunity. [ABSTRACT FROM AUTHOR]

Published
2016
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176. Low Risk of Proximal Tubular Dysfunction Associated With Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis in Men and Women.

Author

Mugwanya, Kenneth, Baeten, Jared, Celum, Connie, Donnell, Deborah, Nickolas, Thomas, Mugo, Nelly, Branch, Andrea, Tappero, Jordan, Kiarie, James, Ronald, Allan, Michael Yin, Wyatt, Christina, Yin, Michael, and Partners PrEP Study Team

Subjects
TENOFOVIR, HIV infections, PREVENTIVE medicine, EMTRICITABINE, GLYCOSURIA
Abstract

Objective: Tenofovir disoproxil fumarate (TDF) is associated with proximal tubular dysfunction (tubulopathy) when used in the treatment of human immunodeficiency virus (HIV) infection. We evaluated whether TDF causes tubulopathy when used as HIV preexposure prophylaxis (PrEP) and whether tubulopathy predicts clinically relevant decline (≥25%) in the estimated glomerular filtration rate (eGFR).Methods: A subgroup analysis of the Partners PrEP Study, a randomized, placebo-controlled trial of daily oral TDF, alone or with emtricitabine (FTC), in HIV-uninfected African men and women (Clinicaltrials.gov NCT00557245). Tubulopathy was assessed in concurrently obtained urine and serum samples at the 24-month or last on-treatment visit, predefined as ≥2 of the following: tubular proteinuria, euglycemic glycosuria, increased urinary phosphate, and uric acid excretion.Results: Of 1549 persons studied (776 receiving FTC-TDF, 773 receiving placebo), 64% were male, and the median age was 37 years. Over a median 24 months of study-drug exposure, the frequency of tubulopathy was 1.7% for FTC-TDF versus 1.3% for placebo (odds ratio, 1.30; 95% confidence interval, .52-3.33; P = .68); Tubulopathy occurred in 2 of 52 persons (3.8%) with versus 3 of 208 (1.4%) without ≥25% eGFR decline (adjusted odds ratio, 1.39; .10-14.0; P > .99).Conclusions: Daily oral FTC-TDF PrEP was not significantly associated with tubulopathy over the course of 24 months, nor did tubulopathy predict clinically relevant eGFR decline. [ABSTRACT FROM AUTHOR]

Published
2016
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177. Desenredando los misterios asociados con la enfermedad por rasguño de gato, angiomatosis bacilar, y síndromes relacionados

Author

Regnery, Rusell and Tappero, Jordan

Subjects
Ciencias Veterinarias, Enfermedades infecciosas, Bartonella
Abstract

La búsqueda de los agentes infecciosos responsables de la enfermedad por rasguño de gato, la angiomatosis bacilar, y síndromes relacionados tiene una larga y frecuentemente tortuosa historia. El reconocimiento de los agentes etiológicos y una nueva comprensión de los aspectos fundamentales de la epidemiología e historia natural de las enfermedades asociadas a Bartonella (anteriormente Rochalimaea) culminan una historia multipartita que combina medicina clínica, microbiología tradicional, y enfoques tecnológicos nuevos para resolver un enigma de larga data., Facultad de Ciencias Veterinarias

Published
1997

179. Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection

Author

Amman, Brian R., primary, Carroll, Serena A., additional, Reed, Zachary D., additional, Sealy, Tara K., additional, Balinandi, Stephen, additional, Swanepoel, Robert, additional, Kemp, Alan, additional, Erickson, Bobbie Rae, additional, Comer, James A., additional, Campbell, Shelley, additional, Cannon, Deborah L., additional, Khristova, Marina L., additional, Atimnedi, Patrick, additional, Paddock, Christopher D., additional, Kent Crockett, Rebekah J., additional, Flietstra, Timothy D., additional, Warfield, Kelly L., additional, Unfer, Robert, additional, Katongole-Mbidde, Edward, additional, Downing, Robert, additional, Tappero, Jordan W., additional, Zaki, Sherif R., additional, Rollin, Pierre E., additional, Ksiazek, Thomas G., additional, Nichol, Stuart T., additional, and Towner, Jonathan S., additional

Published
2012
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180. Preventing Maritime Transfer of ToxigenicVibrio cholerae

Author

Cohen, Nicole J., primary, Slaten, Douglas D., additional, Marano, Nina, additional, Tappero, Jordan W., additional, Wellman, Michael, additional, Albert, Ryan J., additional, Hill, Vincent R., additional, Espey, David, additional, Handzel, Thomas, additional, Henry, Ariel, additional, and Tauxe, Robert V., additional

Published
2012
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181. Antiretroviral Prophylaxis for HIV Prevention in Heterosexual Men and Women

Author

Baeten, Jared M., primary, Donnell, Deborah, additional, Ndase, Patrick, additional, Mugo, Nelly R., additional, Campbell, James D., additional, Wangisi, Jonathan, additional, Tappero, Jordan W., additional, Bukusi, Elizabeth A., additional, Cohen, Craig R., additional, Katabira, Elly, additional, Ronald, Allan, additional, Tumwesigye, Elioda, additional, Were, Edwin, additional, Fife, Kenneth H., additional, Kiarie, James, additional, Farquhar, Carey, additional, John-Stewart, Grace, additional, Kakia, Aloysious, additional, Odoyo, Josephine, additional, Mucunguzi, Akasiima, additional, Nakku-Joloba, Edith, additional, Twesigye, Rogers, additional, Ngure, Kenneth, additional, Apaka, Cosmas, additional, Tamooh, Harrison, additional, Gabona, Fridah, additional, Mujugira, Andrew, additional, Panteleeff, Dana, additional, Thomas, Katherine K., additional, Kidoguchi, Lara, additional, Krows, Meighan, additional, Revall, Jennifer, additional, Morrison, Susan, additional, Haugen, Harald, additional, Emmanuel-Ogier, Mira, additional, Ondrejcek, Lisa, additional, Coombs, Robert W., additional, Frenkel, Lisa, additional, Hendrix, Craig, additional, Bumpus, Namandjé N., additional, Bangsberg, David, additional, Haberer, Jessica E., additional, Stevens, Wendy S., additional, Lingappa, Jairam R., additional, and Celum, Connie, additional

Published
2012
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182. The association between malnutrition and the incidence of malaria among young HIV-infected and -uninfected Ugandan children: a prospective study

Author

Arinaitwe, Emmanuel, primary, Gasasira, Anne, additional, Verret, Wendy, additional, Homsy, Jaco, additional, Wanzira, Humphrey, additional, Kakuru, Abel, additional, Sandison, Taylor G, additional, Young, Sera, additional, Tappero, Jordan W, additional, Kamya, Moses R, additional, and Dorsey, Grant, additional

Published
2012
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184. Efficacy of oral pre-exposure prophylaxis (PrEP) for HIV among women with abnormal vaginal microbiota: a post-hoc analysis of the randomised, placebo-controlled Partners PrEP Study

Author

Heffron, Renee, McClelland, R Scott, Balkus, Jennifer E, Celum, Connie, Cohen, Craig R, Mugo, Nelly, Bukusi, Elizabeth, Donnell, Deborah, Lingappa, Jairam, Kiarie, James, Fiedler, Tina, Munch, Matthew, Fredricks, David N, Baeten, Jared M, Celum, Connie, Baeten, Jared M, Donnell, Deborah, Coombs, Robert W, Frenkel, Lisa, Hendrix, Craig W, Lingappa, Jairam, McElrath, M Juliana, Fife, Kenneth, Were, Edwin, Tumwesigye, Elioda, Ndase, Patrick, Katabira, Elly, Katabira, Elly, Ronald, Allan, Bukusi, Elizabeth, Cohen, Craig, Wangisi, Jonathan, Campbell, James, Tappero, Jordan, Kiarie, James, Farquhar, Carey, John-Stewart, Grace, and Mugo, Nelly Rwamba

Abstract

Daily oral tenofovir-based pre-exposure prophylaxis (PrEP) is high efficacious for HIV prevention among women with high adherence. However, the effect of abnormal vaginal microbiota on PrEP efficacy is of concern. We investigated whether bacterial vaginosis modified the efficacy of oral PrEP.

Published
2017
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187. Epidemic Cholera in a Crowded Urban Environment, Port-au-Prince, Haiti

Author

Dunkle, Stacie, primary, Mba-Jonas, Adamma, additional, Loharikar, Anagha, additional, Fouche, Bernadette, additional, Peck, Mireille, additional, Ayers, Tracy, additional, Archer, W. Roodly, additional, De Rochars, Valery, additional, Bender, Thomas, additional, Moffett, Daphne, additional, Tappero, Jordan, additional, Dahourou, George, additional, Roels, Thierry, additional, and Quick, Robert, additional

Published
2011
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189. Toxigenic Vibrio cholerae O1 in Water and Seafood, Haiti

Author

Hill, Vincent, primary, Cohen, Nicole, additional, Kahler, Amy, additional, Jones, Jessica, additional, Bopp, Cheryl, additional, Marano, Nina, additional, Tarr, Cheryl, additional, Garrett, Nancy, additional, Boncy, Jacques, additional, Henry, Ariel, additional, Gomez, Gerardo, additional, Wellman, Michael, additional, Curtis, Maurice, additional, Freeman, Molly, additional, Turnsek, Maryann, additional, Benner, Ronald, additional, Dahourou, Georges, additional, Espey, David, additional, DePaola, Angelo, additional, Tappero, Jordan, additional, Handzel, Tom, additional, and Tauxe, Robert, additional

Published
2011
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190. Considerations for Oral Cholera Vaccine Use during Outbreak after Earthquake in Haiti, 2010−2011

Author

Date, Kashmira, primary, Vicari, Andrea, additional, Hyde, Terri, additional, Mintz, Eric, additional, Danovaro-Holliday, M. Carolina, additional, Henry, Ariel, additional, Tappero, Jordan, additional, Roels, Thierry, additional, Abrams, Joseph, additional, Burkholder, Brenton, additional, Ruiz-Matus, Cuauhtemoc, additional, Andrus, Jon, additional, and Dietz, Vance, additional

Published
2011
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191. Knowledge, Attitudes, and Practices Related to Treatment and Prevention of Cholera, Haiti, 2010

Author

De Rochars, Valery, primary, Tipret, Julie, additional, Patrick, Molly, additional, Jacobson, Lara, additional, Barbour, Kamil, additional, Berendes, David, additional, Bensyl, Diana, additional, Frazier, Cathie, additional, Domercant, Jean, additional, Archer, Roodly, additional, Roels, Thierry, additional, Tappero, Jordan, additional, and Handzel, Thomas, additional

Published
2011
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192. Determinants of Early and Late Mortality Among HIV-Infected Individuals Receiving Home-Based Antiretroviral Therapy in Rural Uganda

Author

Moore, David M., primary, Yiannoutsos, Constantin T., additional, Musick, Beverly S., additional, Tappero, Jordan, additional, Degerman, Richard, additional, Campbell, James, additional, Were, Willy, additional, Kaharuza, Frank, additional, Alexander, Lorraine N., additional, Downing, Robert, additional, and Mermin, Jonathan, additional

Published
2011
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193. Outbreak of Marburg Hemorrhagic Fever Among Miners in Kamwenge and Ibanda Districts, Uganda, 2007

Author

Adjemian, Jennifer, primary, Farnon, Eileen C., additional, Tschioko, Florimond, additional, Wamala, Joseph F., additional, Byaruhanga, Emmanuel, additional, Bwire, Godfrey S., additional, Kansiime, Edgar, additional, Kagirita, Atek, additional, Ahimbisibwe, Sam, additional, Katunguka, F., additional, Jeffs, Ben, additional, Lutwama, Julius J., additional, Downing, Robert, additional, Tappero, Jordan W., additional, Formenty, Pierre, additional, Amman, Brian, additional, Manning, Craig, additional, Towner, Jonathan, additional, Nichol, Stuart T., additional, and Rollin, Pierre E., additional

Published
2011
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196. Cat-scratch disease and bacillary angiomatosis

Author

Tappero, Jordan W., Koehler, Jane E., Holley, H. Preston, Jr., Tucker, Richard M., Kemper, Carol A., and Bray, David M.

Subjects
Ciprofloxacin -- Health aspects, HIV infection -- Complications, Cat-scratch disease -- Diagnosis
Published
1991

197. Prevalence and correlates of GB virus C infection in HIV-infected and HIV-uninfected pregnant women in Bangkok, Thailand

Author

Bhanich Supapol, Wendy, primary, Remis, Robert S., additional, Raboud, Janet, additional, Millson, Margaret, additional, Tappero, Jordan, additional, Kaul, Rupert, additional, Kulkarni, Prasad, additional, McConnell, Michelle S., additional, Philip, A. Mock, additional, McNicholl, Janet M., additional, Roongpisuthipong, Anuvat, additional, Chotpitayasunondh, Tawee, additional, Shaffer, Nathan, additional, and Butera, Salvatore, additional

Published
2010
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