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153. Eosinophilic Gastritis in a Patient Previously Treated with Dupilumab

Author

Iwamuro, Masaya, Murakami, Toshi, Tanaka, Takehiro, Oka, Shohei, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Subjects
Article Subject
Abstract

A 77-year-old Japanese man with bronchial asthma was treated with dupilumab. Dupilumab treatment was discontinued at the patient’s request after two injections separated by a 2-week interval. The blood eosinophil count was elevated, and an esophagogastroduodenoscopy performed 3 months after dupilumab treatment revealed gastric ulcers; subsequently, eosinophilic gastritis was diagnosed from biopsy examinations. The gastric lesions were resolved by steroid administration. This case report underscores that eosinophil-associated gastrointestinal diseases should be considered in the differential diagnosis of gastric lesions occurring in patients who were treated with dupilumab.

Published
2020
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154. Appendiceal Orifice Inflammation in Ulcerative Colitis Mimicking Mucosa-Associated Lymphoid Tissue Lymphoma in the Cecum

Author

Iwamuro, Masaya, Takahashi, Takahide, Tanaka, Takehiro, Toji, Tomohiro, Hiraoka, Sakiko, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Subjects
Article Subject, immune system diseases, hemic and lymphatic diseases, digestive system diseases
Abstract

A 55-year-old Japanese woman, who had been diagnosed with ulcerative colitis at 18 years of age, underwent screening endoscopy examinations. Esophagogastroduodenoscopy revealed an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the stomach. Colonoscopy showed a slightly elevated reddish lesion with dilated microvessels but no erosions or ulcers. Although MALT lymphoma in the cecum was endoscopically suspected, flow cytometry and pathological analyses led to the diagnosis of appendiceal orifice inflammation in ulcerative colitis. This case highlights the diversity of the endoscopic appearance of appendiceal orifice inflammation in ulcerative colitis.

Published
2020
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155. Intestinal Diffuse Large B-Cell Lymphoma in a Patient with Systemic Lupus Erythematosus

Author

Iwamuro, Masaya, Takahashi, Takahide, Ota, Yoko, Tanaka, Takehiro, Asada, Noboru, Yano, Shuya, Uka, Mayu, Nakamura, Rei, Baba, Yuki, Kawano, Seiji, Kawahara, Yoshiro, and Okada, Hiroyuki

Subjects
Article Subject, immune system diseases, hemic and lymphatic diseases, skin and connective tissue diseases
Abstract

A 44-year-old Japanese woman with systemic lupus erythematosus (SLE) presented to our hospital with abdominal pain. Radiological and endoscopic examinations led to the diagnosis of diffuse large B-cell lymphoma of the jejunum, which was subsequently resected. Patients with SLE reportedly have an increased risk of non-Hodgkin lymphoma, as demonstrated by our patient. Hence, lymphoma should be considered in the differential diagnosis of neoplastic lesions emerging in SLE patients. In addition, flow cytometry using endoscopically biopsied fragments is useful for the immediate diagnosis of lymphoma, leading to timely and accurate preoperative staging.

Published
2020
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156. Additional file 1 of Liquid biopsy for patients with IBD-associated neoplasia

Author

Kinugasa, Hideaki, Hiraoka, Sakiko, Nouso, Kazuhiro, Shumpei Yamamoto, Hirai, Mami, Terasawa, Hiroyuki, Yasutomi, Eriko, Oka, Shohei, Ohmori, Masayasu, Yamasaki, Yasushi, Inokuchi, Toshihiro, Takahara, Masahiro, Harada, Keita, Tanaka, Takehiro, and Okada, Hiroyuki

Abstract

Additional file 1: Supplemental 1. The next-generation sequencing and the digital PCR analysis in control 1 to 10 (Crohn: 1–5; UC: 6–10).

Published
2020
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157. Lanthanum Deposition in the Stomach in the Absence of Helicobacter pylori Infection

Author

Iwamuro, Masaya, Urata, Haruo, Tanaka, Takehiro, Kawano, Seiji, Kawahara, Yoshiro, Kimoto, Katsuhiko, and Okada, Hiroyuki

Subjects
Adult, Male, lanthanum carbonate, scanning electron microscopy analysis, Helicobacter pylori, Stomach Diseases, Case Report, Helicobacter Infections, Asian People, Gastric Mucosa, Lanthanum, Stomach Neoplasms, atrophic gastritis, Humans, hyperphosphatemia, Aged
Abstract

In this case report, we describe two patients who showed a diffusely whitish mucosa in the posterior wall and the lesser curvature of the gastric body. The patients were serologically- and histopathologically-negative for Helicobacter pylori. Random biopsy specimens from the stomach revealed no regenerative changes, intestinal metaplasia, and/or foveolar hyperplasia in either of the patients. Although lanthanum deposition in the gastric mucosa has been reported to occur in close association with H. pylori-associated gastritis, our patients tested negative for H. pylori. These cases suggest that lanthanum deposition presents as whitish lesions in the gastric body in H. pylori-negative patients.

Published
2017

158. Evaluation of complete cold forceps polypectomy resection rate for 3‐ to 5‐mm colorectal polyps

Author

Yamasaki, Yasushi, primary, Harada, Keita, additional, Yamamoto, Shumpei, additional, Yasutomi, Eriko, additional, Hirai, Mami, additional, Ohmori, Masayasu, additional, Oka, Shohei, additional, Inokuchi, Toshihiro, additional, Kinugasa, Hideaki, additional, Sugihara, Yuusaku, additional, Takahara, Masahiro, additional, Hiraoka, Sakiko, additional, Tanaka, Takehiro, additional, Mitsuhashi, Toshiharu, additional, and Okada, Hiroyuki, additional

Published
2020
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159. Heterogeneous distribution of Fusobacterium nucleatum in the progression of colorectal cancer

Author

Yamamoto, Shumpei, primary, Kinugasa, Hideaki, additional, Hirai, Mami, additional, Terasawa, Hiroyuki, additional, Yasutomi, Eriko, additional, Oka, Shohei, additional, Ohmori, Masayasu, additional, Yamasaki, Yasushi, additional, Inokuchi, Toshihiro, additional, Harada, Keita, additional, Hiraoka, Sakiko, additional, Nouso, Kazuhiro, additional, Tanaka, Takehiro, additional, Teraishi, Fuminori, additional, Fujiwara, Toshiyoshi, additional, and Okada, Hiroyuki, additional

Published
2020
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162. The efficacy of pancreatic juice cytology with liquid-based cytology for evaluating malignancy in patients with intraductal papillary mucinous neoplasm

Author

Miyamoto, Kazuya, primary, Matsumoto, Kazuyuki, additional, Kato, Hironari, additional, Yoshida, Ryuichi, additional, Umeda, Yuzo, additional, Inoue, Hirohumi, additional, Tanaka, Takehiro, additional, Matsumi, Akihiro, additional, Saragai, Yosuke, additional, Fujii, Yuki, additional, Yamazaki, Tatsuhiro, additional, Uchida, Daisuke, additional, Tomoda, Takeshi, additional, Horiguchi, Shigeru, additional, Yagi, Takahito, additional, and Okada, Hiroyuki, additional

Published
2020
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165. Randomized trial comparing the 25G and 22G Franseen needles in endoscopic ultrasound‐guided tissue acquisition from solid pancreatic masses for adequate histological assessment.

Author

Tomoda, Takeshi, Kato, Hironari, Fujii, Yuuki, Yamazaki, Tatsuhiro, Matsumoto, Kazuyuki, Horiguchi, Shigeru, Tsutsumi, Koichiro, Inoue, Hirofumi, Tanaka, Takehiro, Mitsuhashi, Toshiharu, and Okada, Hiroyuki

Subjects
ENDOSCOPIC ultrasonography, NEEDLES & pins
Abstract

Background: The effects of the Franseen needle size in endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB) of solid pancreatic masses remain unclear. This study aimed to compare 25G and 22G Franseen needles in terms of adequate tissue acquisition from solid pancreatic masses. Methods: In this single‐center, crossover, randomized noninferiority trial, eligible patients underwent EUS‐FNB with both 25G and 22G Franseen needles in a randomized order between November 2018 and August 2020. Tissue specimens from each pass were separately evaluated based on the cellularity scoring system. The primary outcome was the proportion of acquired specimens allowing adequate histological assessment (cellularity score ≥3). A –15% noninferiority margin was assumed. Results: Data from 88 patients were analyzed, which showed malignant and benign lesions in 84 (95.5%) and four (4.5%) patients, respectively. Of the 88 specimens, 62 (70.5%) and 69 (78.4%) acquired using 25G and 22G needles, respectively, allowed adequate histological assessment. The adjusted proportion difference was –6.6% (95% confidence interval –8.8% to –4.5%), indicating noninferiority of the 25G Franseen needle (P < 0.001). The diagnostic accuracies of the 25G and 22G needles were 86.4% and 89.8%, respectively, with no significant difference (P = 0.180). Adverse events occurred in one patient. Conclusions: The 25G Franseen needle showed a noninferior adequate tissue acquisition and similar diagnostic performance compared to that of the 22G Franseen needle. However, a 15% noninferiority margin was high for clinical use; thus, further consideration is needed (Clinical Trial Registry no. UMIN000034596). [ABSTRACT FROM AUTHOR]

Published
2022
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172. The clinicopathological features of submucosal invasive non-ampullary duodenal carcinoma

Author

Matsueda, Katsunori, primary, Kanzaki, Hiromitsu, additional, Takenaka, Ryuta, additional, Nakagawa, Masahiro, additional, Matsueda, Kazuhiro, additional, Iwamuro, Masaya, additional, Kawano, Seiji, additional, Kawahara, Yoshiro, additional, Toji, Tomohiro, additional, Tanaka, Takehiro, additional, Yagi, Takahito, additional, Fujiwara, Toshiyoshi, additional, and Okada, Hiroyuki, additional

Published
2020
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175. Diagnostic Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in Gastric Mesenchymal Tumors

Author

Iwamuro, Masaya, primary, Miyahara, Koji, additional, Sakaguchi, Chihiro, additional, Takenaka, Ryuta, additional, Kobayashi, Sayo, additional, Mouri, Hirokazu, additional, Tanaka, Shigetomi, additional, Toyokawa, Tatsuya, additional, Tanaka, Shouichi, additional, Nishimura, Mamoru, additional, Yamauchi, Kenji, additional, Tanaka, Takehiro, additional, and Okada, Hiroyuki, additional

Published
2020
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177. Observer agreement for the diagnosis of intestinal acute graft‑vs.‑host disease based on the presence of villous atrophy in the terminal ileum

Author

Sugihara, Yuusaku, primary, Hiraoka, Sakiko, additional, Yasutomi, Eriko, additional, Oka, Shohei, additional, Yamasaki, Yasushi, additional, Inokuchi, Toshihiro, additional, Kinugasa, Hideaki, additional, Takahara, Masahiro, additional, Morito, Yuki, additional, Takahashi, Sakuma, additional, Harada, Keita, additional, Tanaka, Takehiro, additional, Otsuka, Fumio, additional, and Okada, Hiroyuki, additional

Published
2020
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181. Blue laser imaging and linked color imaging improve the color difference value and visibility of colorectal polyps in underwater conditions

Author

Yamasaki, Yasushi, primary, Harada, Keita, additional, Yamamoto, Shumpei, additional, Yasutomi, Eriko, additional, Okanoue, Shotaro, additional, Hirai, Mami, additional, Oka, Shohei, additional, Obayashi, Yuka, additional, Sakae, Hiroyuki, additional, Hamada, Kenta, additional, Inokuchi, Toshihiro, additional, Kinugasa, Hideaki, additional, Sugihara, Yuusaku, additional, Takahara, Masahiro, additional, Tanaka, Takehiro, additional, Hiraoka, Sakiko, additional, Kawahara, Yoshiro, additional, and Okada, Hiroyuki, additional

Published
2020
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193. HepaticCampylobacter jejuniinfection in patients with Castleman‐Kojima disease (idiopathic multicentric Castleman disease with thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) syndrome)

Author

Kageyama, Chihiro, primary, Igawa, Takuro, additional, Gion, Yuka, additional, Iwaki, Noriko, additional, Tabata, Tetsuya, additional, Tanaka, Takehiro, additional, Kondo, Eisei, additional, Sakai, Hajime, additional, Tsuneyama, Koichi, additional, Nomoto, Kazuhiro, additional, Noguchi, Hiroko, additional, Yoshino, Tadashi, additional, Yokota, Kenji, additional, and Sato, Yasuharu, additional

Published
2019
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195. IMMUNOHISTOCHEMICAL ANALYSES OF PTPN6 (SHP1) IN LANGERHANS CELL HISTIOCYTOSIS

Author

Murakami, Ichiro, Oka, Takashi, Sato, Hiaki, Morito, Toshiaki, Takata, Katsuyoshi, Shinno, Yoko, Takano, Masayuki, Washio, Kana, Ko, Shingo, Tamura, Maiko, Ohnishi, Naoko, Ichimura, Koichi, Sato, Yasuharu, Yanai, Hiroyuki, Ohara, Nobuya, Kondo, Eisaku, Takahashi, Kiyoshi, Tanaka, Takehiro, Gogusev, Jean, Jaubert, Francis, Morimoto, Akira, Imashuku, Shinsaku, Akagi, Tadaatsu, and Yoshino, Tadashi

Published
2009

197. Lanthanum Deposition in the Stomach: Usefulness of Scanning Electron Microscopy for Its Detection

Author

Iwamuro, Masaya, Urata, Haruo, Tanaka, Takehiro, Ando, Akemi, Nada, Takahiro, Kimura, Kosuke, Yamauchi, Kenji, Kusumoto, Chiaki, Otsuka, Fumio, and Okada, Hiroyuki

Subjects
inorganic chemicals, xanthoma, endocrine system, lanthanum carbonate, animal structures, scanning electron microscopy analysis, hyperphosphatemia, digestive system
Abstract

After having been treated with lanthanum carbonate administration for 4 years for hyperphosphatemia, a 75-year-old Japanese woman undergoing hemodialysis was diagnosed with lanthanum phosphate deposition in the stomach. The deposition, seen as white microgranules, was observed using esophagogastroduodenoscopy with magnifying observation. To the best of our knowledge, these are the minutest endoscopy images of lanthanum phosphate deposition in the gastric mucosa. Scanning electron microscopy (SEM) observation enabled easier identification of the deposited material, which was visible as bright areas. The present case suggests the usefulness of SEM observation in the detection of lanthanum phosphate deposition in the gastrointestinal tract.

Published
2017

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