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785 results on '"Tanaka, Junya"'

152. Chiral P,Olefin Ligands with Rotamers for Palladium-Catalyzed Asymmetric Allylic Substitution Reactions.

Author

Mino, Takashi, Yamaguchi, Daiki, Kumada, Manami, Youda, Junpei, Saito, Hironori, Tanaka, Junya, Yoshida, Yasushi, and Sakamoto, Masami

Abstract

We synthesized a series of phosphine–olefin-type chiral aminophosphines, and we confirmed that these each exists as two rotamers at the C(aryl)–N(amine) bond. We also investigated the ability of these aminophosphines to act as chiral ligands for Pd-catalyzed asymmetric allylic substitution reactions, such as the alkylation of allylic acetates with malonates or indoles, and we found they gave high enantio-selectivities (up to 98% ee). [ABSTRACT FROM AUTHOR]

Published
2021
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155. Chloride intracellular channel protein 2 in cancer and non-cancer human tissues: relationship with tight junctions

Author

Ueno, Yoshitomo, primary, Ozaki, Saya, additional, Umakoshi, Akihiro, additional, Yano, Hajime, additional, Choudhury, Mohammed E., additional, Abe, Naoki, additional, Sumida, Yutaro, additional, Kuwabara, Jun, additional, Uchida, Rina, additional, Islam, Afsana, additional, Ogawa, Kohei, additional, Ishimaru, Kei, additional, Yorozuya, Toshihiro, additional, Kunieda, Takeharu, additional, Watanabe, Yuji, additional, Takada, Yasutsugu, additional, and Tanaka, Junya, additional

Published
2019
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157. Disposable Robotic Finger Driven Pneumatically by Flat Tubes and a Hollow Link Mechanism.

Author

Tanaka, Junya and Matsuhira, Nobuto

Subjects
*ROBOTICS, *ACTUATORS, *WEIGHT-bearing (Orthopedics), *ROBOTIC exoskeletons, *PNEUMATICS
Abstract

We propose a robotic finger with an exoskeleton-type structure that bends and extends by the deformation force of flat tubes. Our objective is to realize a disposable robot hand for gripping unsanitary objects. To reduce the cost of disposing of the robotic finger, a commercially available cable carrier chain was used for the exoskeleton component, and the flat tubes used in the pneumatic actuator were prepared by thermal processing of a commercially available tube. The driving joint of the robotic finger consists of a hollow link mechanism and two flat tubes, which are respectively arranged inside the hollow link mechanism and at the joint boundary. The proposed joint structure achieves both smooth drivability and good load-bearing capacity. The developed robotic finger weighs approximately 85 g and generates a fingertip force of approximately 4 N when a pressure of 0.25 MPa is applied. Because the developed robotic finger is pneumatically driven, it conforms to the object shape and is compliant to external force. Verification of the mechanism demonstrated that the developed robotic finger is useful because it was able to grasp six types of assumed objects. [ABSTRACT FROM AUTHOR]

Published
2020
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158. Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma.

Author

Sanada, Tomoyoshi, Islam, Afsana, Kaminota, Teppei, Kirino, Yui, Tanimoto, Reina, Yoshimitsu, Hana, Yano, Hajime, Mizuno, Yosuke, Okada, Masahiro, Mitani, Souhei, Ugumori, Tohru, Tanaka, Junya, and Hato, Naohito

Abstract

Objectives: The secretory enzyme lysyl oxidase like 2 (LOXL2) is speculated to contribute to tumor progression through its functions in the remodeling of extracellular matrix and epithelial-mesenchymal transition. We previously identified elevated expression of LOXL2 in metastatic human head and neck squamous cell carcinoma (HNSCC) cells in a mouse lymph node metastases model. Here we performed a case series study examining LOXL2 expression levels in human serum from HNSCC patients to evaluate whether LOXL2 is worth evaluation in a large cohort study.Methods: LOXL2 protein levels in three serum samples from HNSCC patients were assessed by immunoblotting and LOXL2 tissue expression was examined in one human tongue squamous cell carcinoma (SCC) tissue by immunohistochemistry as a representative of HNSCC tissue. Serum samples were further fractionated in exosomes and supernatants by ultracentrifugation, which were then subjected to immunoblot and in vitro LOX activity analyses. Exosomal LOXL2 levels of 36 serum samples from HNSCC patients and seven healthy volunteers were measured using polymer sedimentation exosome preparation followed by ELISA measurement and subjected to statistical analyses.Results: Immunoblot analyses revealed that LOXL2 was present in serum exosomal fractions from three HNSCC patients, and we observed approximately threefold higher levels of LOXL2 in HNSCC patients compared with three healthy volunteers. Immunohistochemical LOXL2 staining was detected in HNSCC cells in addition to non-cancerous lipid tissues and some muscles in human tongue HNSCC tissue. Further measurements of exosomal LOXL2 by ELISA showed over ninefold higher mean LOXL2 levels in patients compared with controls. Statistical analysis revealed a correlation between elevated serum exosomal LOXL2 levels and low-grade, but not high-grade, HNSCC.Conclusions: Our case series study that elevated serum exosomal LOXL2 levels exhibited a correlation with low-grade HNSCCs. A follow-up large cohort clinical study will be required to determine the potential clinical utility of LOXL2 as a new biomarker and/or therapy target for HNSCCs.Level Of Evidence: 4 Laryngoscope, 130:E327-E334, 2020. [ABSTRACT FROM AUTHOR]

Published
2020
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159. Portable compact suction pad unit for parallel grippers.

Author

Tanaka, Junya, Yamamoto, Daisuke, Ogawa, Hideki, Ohtsu, Hiroshi, Kamata, Keisuke, and Nara, Kohei

Subjects
VACUUM, ROBOTS
Abstract

This paper proposes a portable compact suction pad unit for the parallel grippers of a mobile manipulation robot to place items for product display. In addition, this paper includes verification of the unit's mechanism. Given that robots have to hold various items, we propose an operation method by which the parallel gripper holding the compact suction pad unit switches between a pinching mode and a vacuum suction mode depending on the item being placed. The compact suction pad unit is self-contained, with all the devices necessary for the suction operation inside the unit. The suction operation is switched on and off wirelessly by an external host system controller. The compact suction pad unit produced a suction force of about 5.6 N at an allowable inclination angle of 15°. We demonstrated in a competition that our proposed operation method of the compact suction pad unit is useful by having it place a beverage in a cup with lid and a boxed lunch. [ABSTRACT FROM AUTHOR]

Published
2020
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160. Enhancement of antitumor activity by using 5-ALA–mediated sonodynamic therapy to induce apoptosis in malignant gliomas: significance of high-intensity focused ultrasound on 5-ALA-SDT in a mouse glioma model

Author

Suehiro, Satoshi, primary, Ohnishi, Takanori, additional, Yamashita, Daisuke, additional, Kohno, Shohei, additional, Inoue, Akihiro, additional, Nishikawa, Masahiro, additional, Ohue, Shiro, additional, Tanaka, Junya, additional, and Kunieda, Takeharu, additional

Published
2018
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163. Comparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: A study using a hypnotic bromovalerylurea

Author

Abe, Naoki, primary, Choudhury, Mohammed E., additional, Watanabe, Minori, additional, Kawasaki, Shun, additional, Nishihara, Tasuku, additional, Yano, Hajime, additional, Matsumoto, Shirabe, additional, Kunieda, Takehiro, additional, Kumon, Yoshiaki, additional, Yorozuya, Toshihiro, additional, and Tanaka, Junya, additional

Published
2018
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164. Significance of Glioma Stem-Like Cells in the Tumor Periphery That Express High Levels of CD44 in Tumor Invasion, Early Progression, and Poor Prognosis in Glioblastoma

Author

Nishikawa, Masahiro, primary, Inoue, Akihiro, additional, Ohnishi, Takanori, additional, Kohno, Shohei, additional, Ohue, Shiro, additional, Matsumoto, Shirabe, additional, Suehiro, Satoshi, additional, Yamashita, Daisuke, additional, Ozaki, Saya, additional, Watanabe, Hideaki, additional, Yano, Hajime, additional, Takahashi, Hisaaki, additional, Kitazawa, Riko, additional, Tanaka, Junya, additional, and Kunieda, Takeharu, additional

Published
2018
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171. Elevated Na + /H + exchanger-1 expression enhances the metastatic collective migration of head and neck squamous cell carcinoma cells

Author

Kaminota, Teppei, primary, Yano, Hajime, additional, Shiota, Kohei, additional, Nomura, Noriko, additional, Yaguchi, Haruna, additional, Kirino, Yui, additional, Ohara, Kentaro, additional, Tetsumura, Issei, additional, Sanada, Tomoyoshi, additional, Ugumori, Toru, additional, Tanaka, Junya, additional, and Hato, Naohito, additional

Published
2017
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175. Taro kojiof Amorphophallus konjacenabling hydrolysis of konjac polysaccharides to various biotechnological interest

Author

Adachi, Osao, Hours, Roque A., Akakabe, Yoshihiko, Arima, Hideyuki, Taneba, Rie, Tanaka, Junya, Kataoka, Naoya, Matsushita, Kazunobu, and Yakushi, Toshiharu

Abstract

ABSTRACTDue to the indigestibility, utilization of konjac taro, Amorphophallus konjachas been limited only to the Japanese traditional konjac food. Kojipreparation with konjac taro was examined to utilize konjac taro as a source of utilizable carbohydrates. Aspergillus luchuensisAKU 3302 was selected as a favorable strain for kojipreparation, while Aspergillus oryzaeused extensively in sakebrewing industry was not so effective. Asp. luchuensisgrew well over steamed konjac taro by extending hyphae with least conidia formation. Kojipreparation was completed after 3-day incubation at 30°C. D-Mannose and D-glucose were the major monosaccharides found in a hydrolyzate giving the total sugar yield of 50 g from 100 g of dried konjac taro. An apparent extent of konjac taro hydrolysis at 55°C for 24 h seemed to be completed. Since konjac taro is hydrolyzed into monosaccharides, utilization of konjac taro carbohydrates may become possible to various products of biotechnological interest.

Published
2020
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179. Goreisan Inhibits Upregulation of Aquaporin 4 and Formation of Cerebral Edema in the Rat Model of Juvenile Hypoxic-Ischemic Encephalopathy

Author

Yano, Yoshiaki, primary, Yano, Hajime, additional, Takahashi, Hisaaki, additional, Yoshimoto, Kouhei, additional, Tsuda, Shinji, additional, Fujiyama, Kenta, additional, Izumo-Shimizu, Yusuke, additional, Motoie, Ryota, additional, Ito, Masanori, additional, Tanaka, Junya, additional, Ishii, Eiichi, additional, and Fukuda, Mitsumasa, additional

Published
2017
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199. Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma

Author

Takahashi, Hisaaki, primary, Inoue, Akihiro, additional, Kawabe, Yuya, additional, Hosokawa, Yuki, additional, Iwata, Shinji, additional, Sugimoto, Kana, additional, Yano, Hajime, additional, Yamashita, Daisuke, additional, Harada, Hironobu, additional, Kohno, Shohei, additional, Ohue, Shiro, additional, Ohnishi, Takanori, additional, and Tanaka, Junya, additional

Published
2014
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