Search

Sanger traces of each of the four variants of interest found across six pedigrees. (DOCX 1252 kb)

Percentage of bases covered for HSPA1L, HSPA1A, and HSPA1B in the Agilent SureSelect V4 and V5 kits. (DOCX 42 kb)

Results of SKAT-O within HSPA1L using non-synonymous and non-frameshift variants, excluding common variants (MAFâ >â 0.05). (DOCX 51 kb)

The effects of hypoxia on astroglial glucose metabolism of glycolysis, pentose-phosphate pathway, and TCA cycle. (DOCX 212 kb)

Low global warming refrigerants such as HFO (hydro fluoro olefin) -1234yf are attracted as an alternative working fluid in air-conditioning and cooling systems to address global warming. However, it used to require larger compressor size due to the lower fluid density compared with conventional refrigerants such as R410A. Thus, a new wing-vane compressor which has no contraction between the vane and the cylinder is developed to prevent increase in the size without performance degradation. The structure of the wing-vane compressor is different from the conventional vane compressor. Therefore, a prototype of the wing-vane compressor was operated using R134a refrigerant to simulate HFO-1234yf refrigerant. The results are as follows: (1) The steady operation is observed in the general operating condition. (2) The steady mechanism of vane is clarified by both experiment and simulation. (3) A simple lubrication structure is achieved by supplying the oil to the friction surface through the grooves with the partial arc guide bearings.

Quantification of metabolites in astroglial pentose-phosphate pathway by capillary-electrophoresis/electrospray ionization (CE/ESI) MS. (DOCX 20 kb)

Low global warming refrigerants such as HFO (hydro fluoro olefin) -1234yf are attracted as an alternative working fluid in air-conditioning and cooling systems to address global warming. However, it used to require larger compressor size due to the lower fluid density compared with conventional refrigerants such as R410A. Thus, a new wing-vane compressor which has no contraction between the vane and the cylinder is developed to prevent increase in the size without performance degradation. Â Rotary motion of the vane is supported by the partial arc guide on the upper and lower ends of the vane. Revealing the lubricating properties of the guide was one of the development issues. Â So we have analyzed the guide bearing performance such as friction coefficient and oil film thickness with fluid dynamics lubrication model of the guide bearing. And we measured the friction coefficient of the guide bearing by experiment. The analysis model was validated by comparing the simulated friction coefficient and that of experiment. In addition, we examined the effect of the shape of the guide bearing on the lubricating properties. The results are as follows: (1)When the load is applied to the center of the guide arc angle, the friction coefficient of the analysis and experiment result is in good agreement. (2)The friction coefficient of the guide bearing can be organized in Stribeck diagram as well as full journal bearing in the fluid lubrication region.

Research team head, Research team member, Research team member

Energy security and global warming are critical environmental issues. It is an important role for vehicle manufacturers to develop technologies for reducing greenhouse gas, especially CO2 emission. Nissan has been focusing on both electrification and intelligence technologies so far, including battery and fuel cells technologies as a part of "Nissan Intelligent Mobility".1 The biggest issues to popularize fuel cell electric vehicles (FCEVs) in the market are cost reduction of polymer electrolyte fuel cell (PEFC) power system, and development of hydrogen infrastructure. Related to the former issue, one of the most significant challenges is to reduce platinum group metals (PGM) in fuel cell stacks. PGM are used as electrocatalyst and contained in catalyst layers (CLs) of membrane electrode assemblies (MEAs) in the stack. A lot of research activities on PEFC electrocatalyst have been reported so far, indicating high oxygen reduction reaction (ORR) activity and durability mainly measured in aqueous electrolyte systems such as a rotating disk electrode method.2-8 On the other hand, electrocatalyst is mixed with electrolyte to form CLs through deposition and solidification process. From industrial point of view, it is needed that performance of the electrocatalyst should be guaranteed as CL in MEA. CL is a multi-scale component, i.e. micro-scale porous electrode consisting of nano-scale materials, where electrochemical reaction and mass transport occur simultaneously. Micro and nano structure of CL has been revealed gradually by means of characterization techniques remarkably progressed recently, such as electron microscope.9,10 However, it is still under development to characterize and diagnose structure and properties of CLs as overall and average value. To design low-PGM loaded CLs without scarifying performance, Nissan has been trying to understand the correlation between materials and CL/MEAs through properties and structure via key mechanism.11-15 Recently, process analysis such as catalyst ink microstructure has been more focused.16-18 In this presentation, current status and challenges of CL/electrocatalyst design and development at Nissan will be introduced. References 1. http://www.nissan-global.com/JP/NEWS/2016/_STORY/160302-01-j.html 2. C. Chen, Y. Kang, Z. Huo, Z. Zhu, W. Huang, H.L. Xin, J.D. Snyder, D. Li, J.A. Herron, M. Mavrikakis, M. Chi, K.L. More, Y. Li, N.M. Markovic, G.A. Somorjai, P. Yang, V.R. Stamenkovic, Scienceexpress 27 February 2014. 3. R.R. Adzic, Electrocatal. 3 (2012) 163. 4. S.M. Alia, K. Jensen, C. Contreras, F. Garzon, B. Pivovar, Y. Yan, ACS Catal. 3 (2013) 358. 5. A.B. Papandrew, R.W. Atkinson III, G.A. Goenaga, S.S. Kocha, J.W. Zack, B.S. Pivovar, T.A. Zawodzinski Jr., J. Electrochem. Soc. 160 (2013) F848. 6. H. Yano, T. Akiyama, M. Watanabe, H. Uchida, J. Electroanal. Chem. 688 (2013) 137. 7. H. Daimon, M. Inaba, Electrochemistry 81 (2013) 641645. 8. A. Ishihara, M. Tamura,Y. Ohgi, M. Matsumoto, K. Matsuzawa, S. Mitsushima, H. Imai, K. Ota, J. Phys. Chem. C 117 (2013) 18837. 9. B. Arumugam, B.A. Kakade, T. Tamaki, M. Arao, H. Imai, T. Yamaguchi, RSC Adv. 4 (2014) 27510. 10. K.L. More, "Characterization of Fuel Cell Materials", Proceeding of 2016 DOE Annual Merit Review, Washington D.C. June 2016. 11. A. Ohma, T. Mashio, K. Sato, H. Iden, Y. Ono, K. Sakai, K. Akizuki, S. Takaichi, Kazuhiko Shinohara, Electrochim. Acta 56 (2011) 10832. 12. T. Mashio, A. Ohma, S. Yamamoto, K. Shinohara, ECS Trans. 11 (2007) 529. 13. H. Iden, T. Mashio, A. Ohma, J. Electroanal. Chem. 708 (2013) 87. 14. K. Sato, A. Ohma, K. Yamaguchi, K. Shinohara, ECS Trans. 19 (2009) 39. 15. H. Iden, A. Ohma, T. Tokunaga, K. Yokoyama, K. Shinohara, PCCP 18 (2016) 13066. 16. S. Takahashi, T. Mashio, N. Horibe, K. Akizuki, A. Ohma, ChemElectroChem 2, 1560, 69 (2015). 17. T. Mashio, A. Ohma, T. Tokumashu, Electrochim. Acta 202 (2016) 14. 18. S. Takahashi, J. Shimanuki, T. Mashio, A. Ohma, H. Tohma, A. Ishihara, Y. Ito, Y. Nishino, A. Miyazawa, Electrochim. Acta 224 (2017) 178.