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1,051 results on '"Taha, Muhamed-Kheir"'

152. Strain coverage of Bexsero vaccine assessed by whole-genome sequencing over a cohort of invasive meningococci of serogroups B and W isolated in Switzerland

Author

Leo, Stefano, primary, Lazarevic, Vladimir, additional, Girard, Myriam, additional, Getaz-Jimenez Velasco, Gisela C., additional, Gaïa, Nadia, additional, Renzi, Gesuele, additional, Cherkaoui, Abdessalam, additional, Hong, Eva, additional, Taha, Muhamed-Kheir, additional, and Schrenzel, Jacques, additional

Published
2020
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155. Validation of a New Rapid Detection Test for Detection of Neisseria meningitidis A/C/W/X/Y Antigens in Cerebrospinal Fluid

Author

Haddar, Cyrille H., primary, Terrade, Aude, additional, Verhoeven, Paul, additional, Njanpop-Lafourcade, Berthe-Marie, additional, Dosso, Mireille, additional, Sidikou, Fati, additional, Mahamane, Ali Elhaj, additional, Lombart, Jean-Pierre, additional, Razki, Aziza, additional, Hong, Eva, additional, Agnememel, Alain, additional, Begaud, Evelyne, additional, Germani, Yves, additional, Pozzetto, Bruno, additional, and Taha, Muhamed-Kheir, additional

Published
2020
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156. Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis

Author

Williams, Allison Hillary, primary, Wheeler, Richard, additional, Deghmane, Ala-Eddine, additional, Santecchia, Ignacio, additional, Schaub, Ryan E, additional, Hicham, Samia, additional, Moya Nilges, Maryse, additional, Malosse, Christian, additional, Chamot-Rooke, Julia, additional, Haouz, Ahmed, additional, Dillard, Joseph P, additional, Robins, William P, additional, Taha, Muhamed-Kheir, additional, and Gomperts Boneca, Ivo, additional

Published
2020
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161. Evolving strategies for meningococcal vaccination in Europe: Overview and key determinants for current and future considerations.

Author

Martinón-Torres, Federico, Taha, Muhamed-Kheir, Knuf, Markus, Abbing-Karahagopian, Victoria, Pellegrini, Michele, Bekkat-Berkani, Rafik, and Abitbol, Véronique

Subjects
MENINGOCOCCAL infections, MENINGOCOCCAL vaccines, IMMUNIZATION, EPIDEMIOLOGY
Abstract

Invasive meningococcal disease (IMD) is a life-threatening, unpredictable condition. Vaccines are available against 5 of the 6 meningococcal serogroups (Men) accounting for nearly all IMD cases worldwide; conjugate monovalent MenC, quadrivalent MenACWY, and protein-based MenB vaccines are commonly used. We provide a comprehensive overview of the evolution of meningococcal vaccination strategies employed in national immunization programmes (NIPs) and their impact on IMD incidence in Europe. A more in-depth description is given for several countries: the United Kingdom (UK), the Netherlands, Greece, Italy, and Ireland. We searched European health authorities' websites and PubMed. Various vaccines and immunization schedules are used in 21 NIPs. Most countries implement MenC vaccination in infants, MenACWY in adolescents, and a growing number, MenB in infants. Only Malta has introduced MenACWY vaccination in infants, and several countries reimburse immunization of toddlers. The UK, Italy, Ireland, Malta, Andorra, and San Marino recommend MenB vaccination in infants and MenACWY vaccination in adolescents, targeting the most prevalent serogroups in the most impacted age groups. Main factors determining new vaccination strategies are fluctuating IMD epidemiology, ease of vaccine implementation, ability to induce herd protection, favorable benefit–risk balance, and acceptable cost-effectiveness. Since 1999, when the UK introduced MenC vaccination, the reduction in IMD incidence has been gradually enhanced as other countries adopted routine meningococcal vaccinations. Meningococcal vaccination strategies in each country are continually adapted to regional epidemiology and national healthcare priorities. Future strategies may include broader coverage vaccines when available (e.g., MenABCWY, MenACWY), depending on prevailing epidemiology. [ABSTRACT FROM AUTHOR]

Published
2022
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162. Global epidemiology and changing clinical presentations of invasive meningococcal disease: a narrative review.

Author

Deghmane, Ala-Eddine, Taha, Samy, and Taha, Muhamed-Kheir

Subjects
MENINGOCOCCAL infections, SYMPTOMS, CLINICAL epidemiology, NEISSERIA meningitidis, INFECTIOUS arthritis, DEATH rate
Abstract

Neisseria meningitidis (the meningococcus) causes significant morbidity and mortality worldwide through an epidemic or sporadic invasive infections. The epidemiology of N. meningitidis is changing and unpredictable. Certain emerging meningococcal genotypes seem to be associated with increasing unusual clinical presentations. Indeed, early symptoms may vary and are frequently non-specific. However, atypical clinical forms including abdominal presentations, septic arthritis, and bacteremic pneumonia may lead to misdiagnosis and some are usually associated with higher case fatality rates due to delayed optimal management. Improving awareness of clinicians and public health specialists about these unusual but potentially severe presentations should help establish prompt diagnoses and provide appropriate management of cases. In this review, we described unusual panels of clinical presentations of invasive meningococcal disease linked to the recent changes in meningococcal epidemiology. [ABSTRACT FROM AUTHOR]

Published
2022
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164. Contributors

Author

Adachi, Hideki, primary, Adachi, Osao, additional, Adam, Zach, additional, Adams, Michael W.W., additional, Adang, Michael J., additional, Adham, Ibrahim M., additional, Aducci, Patrizia, additional, Agard, David A., additional, Agranovsky, Alexey A., additional, Ahn, Kyunghye, additional, Akiyama, Yoshinori, additional, Alejo, Alí, additional, Amberg, Sean M., additional, Amerik, Alexander Y., additional, Andrés, Germán, additional, Andrews, Robert K., additional, Antalis, Toni M., additional, Apte, Suneel S., additional, Arima, Kazunari, additional, Arlaud, Gérard J., additional, Aronson, Nathan N., additional, Asano, Yasuhisa, additional, Ascenzi, Paolo, additional, Assakura, Marina T., additional, Auld, David S., additional, Avilés, Francesc X., additional, Awad, William M., additional, Babé, Lilia M., additional, Badorff, Cornel, additional, Bai, Shan, additional, Baird, Teaster T., additional, Paul Bajaj, S., additional, Baker, Rohan T., additional, Baker, Susan C., additional, Ballinger, Marcus D., additional, Banbula, Agnieszka, additional, Bannikov, Gregory A., additional, Barrett, Alan J., additional, Bartlett, John D., additional, Baskova, Isolda P., additional, Bauer, Karl, additional, Baumann, Ulrich, additional, Baumeister, Wolfgang, additional, Beauvais, Anne, additional, Belas, Robert, additional, Beppu, Teruhiko, additional, Bergmann, Ernst M., additional, Bergo, Martin O., additional, Berndt, Michael C., additional, Berry, Colin, additional, Bertenshaw, Greg P., additional, Betzel, Ch., additional, Bierbaum, Gabriele, additional, Bieth, Joseph G., additional, Bjarnason, Jón B., additional, Blaber, M., additional, Blaber, S.I., additional, Black, Roy A., additional, Blackman, M.J., additional, Blinkovsky, Alexander, additional, Blobel, Carl P., additional, Boatright, Kelly M., additional, Böck, August, additional, Boeke, Jef D., additional, Boileau, Guy, additional, Bolken, Tové C., additional, Bond, Judith S., additional, Bordallo, Javier, additional, Bordusa, Frank, additional, Boucaut, Kerry J., additional, Bouvier, Jacques, additional, Bowman, Barry J., additional, Bradshaw, Ralph A., additional, Braun, Hans-Peter, additional, Breddam, Klaus, additional, Brindley, Paul J., additional, Broadhurst, Anne, additional, Brocklehurst, Keith, additional, Broder, Dan H., additional, Brömme, Dieter, additional, Bron, Sierd, additional, Broom, Murray, additional, Brown, Kenneth D., additional, Brown, Mark A., additional, Bunn, Rhonda, additional, Burleigh, Barbara A., additional, Butler, Michael J., additional, Buttle, David J., additional, Byrd, Chelsea M., additional, Byun, Tony, additional, Cadel, Sandrine, additional, Caffrey, Conor R., additional, Caldentey, Javier, additional, Caprioglio, Daniel R., additional, Carbonell, Juan, additional, Carpentier, Mélanie, additional, Carter, Ruth E., additional, Casey, Patrick J., additional, Castellino, Francis J., additional, Catanese, Joseph J., additional, Caterson, Bruce, additional, Caughey, George H., additional, Cawley, Niamh X., additional, Cawston, Tim E., additional, Jose Cazzulo, Juan, additional, Cercós, Manuel, additional, Chakraborty, Trinad, additional, Chambers, Henry F., additional, Chang, L.S., additional, Chan, Michael K., additional, Chan, Sunney I., additional, Chao, Julie, additional, Chapot-Chartier, Marie-Pierre, additional, Chave, Karen J., additional, Chen, Jian-Min, additional, Chen, Jinq-May, additional, Chesneau, Valérie, additional, Chevrier, Bernard, additional, Chich, Jean-François, additional, Yong Choi, Kwan, additional, Chrétien, Michel, additional, Ha Chung, Chin, additional, Chung, Dominic W., additional, Clamagirand, Christine, additional, Clark, Ian M., additional, Clarke, Adrian K., additional, Clarke, Steven, additional, Cleary, Paul P., additional, Clements, Judith A., additional, Cleuziat, Philippe, additional, Cohen, Paul, additional, Colige, Alain, additional, Collen, D., additional, Collier, Ivan E., additional, Colloms, Sean D., additional, Colman, Robert W., additional, Conner, Gregory E., additional, Conzelmann, Andreas, additional, Coolbear, Tim, additional, Coombs, Graham H., additional, Cooper, Jonathan B., additional, Cooper, Max D., additional, Copeland, Nikki A., additional, Corvol, Pierre, additional, Cottrell, Graeme S., additional, Coyle, Joseph T., additional, Craik, Charles S., additional, Creemers, John W.M., additional, Croce, Jenifer, additional, Cueva, Rosario, additional, Cutting, Simon, additional, d′Enfert, Christophe, additional, D′Orchymont, Hugues, additional, Daenke, S., additional, Dahlbäck, Björn, additional, Dalbey, Ross E., additional, Dalton, John P., additional, Dando (Deceased), Pamela M., additional, Daniel, R.M., additional, Darke, Paul L., additional, Lagerblad de Oliveira, Pedro, additional, de Vos, Sarah, additional, Deghmane, Ala-Eddine, additional, Dekker, Niek, additional, DeLotto, Robert, additional, DeMartino, George N., additional, den Boon, Johan A., additional, Denison, Mark R., additional, DesGroseillers, Luc, additional, Deussing, Jan, additional, Devi, Lakshmi A., additional, Diamandis, Eleftherios P., additional, Dickson, Robert B., additional, Dingwall, Colin, additional, Dixon, Jack E., additional, Dodt, Johannes, additional, Dolenc, Iztoc, additional, Cat Dong, Tran, additional, Dong, Ying, additional, Dubois, Jean-Yves F., additional, Dudley, Edward G., additional, Dunn, Ben M., additional, Dupuy, Bruno, additional, Conceicão Duque-Magalhães, Maria, additional, Eeckhout, Yves, additional, Egelrud, Torbjörn, additional, Eijsink, Vincent, additional, Ellis, Vincent, additional, Engel, Wolfgang, additional, Erdös, Ervin G., additional, Etscheid, Michael, additional, Evans (Deceased), Herbert J., additional, Everett, Roger D., additional, Eyries, Mélanie, additional, Fahrenholz, Falk, additional, Fenster, Kurt M., additional, Férec, Claude, additional, Henrique Ferreira Sorgine, Marcos, additional, Fink, Doran, additional, Fives-Taylor, Paula M., additional, Foltmann, Bent, additional, Foster, Simon J., additional, Foulon, Thierry, additional, Foundling, Stephen I., additional, Fox, Jay W., additional, Freeze, Hudson H., additional, Frère, Jean-Marie, additional, Frey, Teryl K., additional, Flicker, Lloyd D., additional, Fritsche, Erich, additional, Froelich, Christopher J., additional, Fuhrmann, Cynthia N., additional, Fujimura, Satoshi, additional, Fukushima, J., additional, Fuller, Robert S., additional, Gaboriaud, Christine, additional, Gache, Christian, additional, Galivan, John, additional, Gary, Jonathan D., additional, Gaucher, G.M., additional, Ghuysen, Jean-Marie, additional, Gil, María J., additional, Giller, Thomas, additional, Goffin, Colette, additional, Gohda, Eiichi, additional, Goldberg, Alfred L., additional, Goldberg, Daniel E., additional, Goldberg, Gregory I., additional, Gorbalenya, Alexander E., additional, Gordon, Stuart G., additional, Götz, Friedrich, additional, Gráf, László, additional, Granados, Robert R., additional, Granell, Antonio, additional, Graycar, Thomas P., additional, Green, Jonathan, additional, Greenspan, Daniel S., additional, Grubman, Marvin J., additional, Grunden, Amy M., additional, Guillemain, Bernard, additional, Guinand, Micheline, additional, Gutiérrez, José Maria, additional, Haeggström, Jesper Z., additional, Hageman, James H., additional, Hagmann, Marie-Luise, additional, Halfon, Sherin, additional, Hamilton, Andrew J., additional, Seon Han, Ji, additional, Hara-Nishimura, Ikuko, additional, Harada, Minoru, additional, Hartzell, William O., additional, Hay, Rod J., additional, Hayashi, Kiyoshi, additional, Hendriks, Dirk F., additional, Henrich, Bernhard, additional, Henriet, Patrick, additional, Hernández-Arana, Andrés, additional, Herrera-Camacho, Irma, additional, Heusipp, Gerhard, additional, Hicks, P.M., additional, Hillman, Bradley I., additional, Yukihiro Hiraoka, B., additional, Hiratake, Jun, additional, Ho, Heng-Chien, additional, Thi Hoa, Ngo, additional, Hochstrasser, Mark, additional, Hofmann, Theo, additional, Hohn, Thomas, additional, Hoidal, John R., additional, Holbrook, Joanna D., additional, Höltje, Joachim-Volker, additional, Homma, Koichi J., additional, Hook, Vivian Y.H., additional, Hooper, John D., additional, Hooper, Nigel M., additional, Hosoi, Kazuo, additional, Hospital, Véronique, additional, Howe, Christopher J., additional, Hruby, Dennis E., additional, Huang, H.-C., additional, Huber, Robert, additional, Hughes, Clare E., additional, Ibrahim-Granet, Oumaïma, additional, Ichishima, Eiji, additional, Ikehara, Yukio, additional, Imamura, Takahisa, additional, Inagaki, Noritoshi, additional, Inagami, Tadashi, additional, Isaac, R.E., additional, Isaya, Grazia, additional, Ishihara, Kohji, additional, Ishii, Shin-ichi, additional, Itoh, Yoshifumi, additional, Ito, Kiyoshi, additional, Ito, Koreaki, additional, Iwanaga, Sadaaki, additional, Jack, Ralph W., additional, Jackson, Mel C., additional, James, Michael N.G., additional, Jeffrey (Deceased), John, additional, Jiang, Ping, additional, Johnson, Gary D., additional, Johnson, John E., additional, Johnson, Michael, additional, Albert Johnston, Stephen, additional, Jones, Elizabeth W., additional, Jongbloed, Jan D.H., additional, Joshua-Tor, Leemor, additional, Joudiou, Carine, additional, Juliano, Luiz, additional, Jupp, Ray, additional, Kaminogawa, Shuichi, additional, Kamio, Yoshiyuki, additional, Kan, Chen-Chen, additional, Kaneda, Makoto, additional, Gyun Kang, Sung, additional, Kania, Mary, additional, Kanjanahaluethai, Amornrat, additional, Kawabata, Shun-ichiro, additional, Kay, John, additional, Keiler, Kenneth C., additional, Kelly, R.M., additional, Kerr, Michael A, additional, Kervinen, Jukka, additional, Kessler, Efrat, additional, Kidd, Simon, additional, Kilian, Mogens, additional, Kim, Do-Hyung, additional, Seop Kim, In, additional, Kimura, Yukio, additional, Kirisako, Takayoshi, additional, Kirschke, Heidrun, additional, Kishi, Tadaaki, additional, Kitamura, Naomi, additional, Kitazono, Ana A., additional, Kleanthous, Colin, additional, Klein, Jürgen R., additional, Kobayashi, Hideyuki, additional, Koelsch, Gerald, additional, Kok, Jan, additional, Kolattukudy, P.E., additional, Kolmar, Harald, additional, Komori, Yumiko, additional, Konvalinka, Jan, additional, Korhonen, Timo K., additional, Kortt, Alexander A., additional, Kräusslich, Hans-Georg, additional, Kress, Lawrence F., additional, Kubo, Takeaki, additional, Kukkonen, Maini, additional, Kumagai, Hidehiko, additional, Kumazaki, Takashi, additional, Kümmerer, Beate M., additional, Kuno, Kouji, additional, Kurachi, Kotoku, additional, Kurkinen, Markku, additional, Lähteenmäki, Kaarina, additional, Laing, Gavin D., additional, Lambkin, Imelda J., additional, Lamppa, Gayle K., additional, Lång, Hannu, additional, Langer, Thomas, additional, Laursen, Richard A., additional, Le Bonniec, Bernard F., additional, Luel Lee, Bok, additional, Joon Lee, Kye, additional, Young Lee, So, additional, Lee, Soohee, additional, Leis, Jonathan, additional, LeMosy, Ellen K., additional, Lepage, Thierry, additional, Leppla, Stephen H., additional, Lessard, Ivan A.D., additional, Lhomond, Guy, additional, Liao, Ta-Hsiu, additional, Lieber, Toby, additional, Lijnen, H.R., additional, Lima, Christopher D., additional, Lin, Chen-Yong, additional, Lin, Xinli, additional, Lindsay, L.L., additional, Lipscomb, William N., additional, Little, Christopher B., additional, Little, John W., additional, Lively, Mark O., additional, Lobel, Peter, additional, Peng Loh, Y., additional, Lohi, Jouko, additional, Lomonossoff, G.P., additional, Looze, Yvan, additional, López-García, Alma, additional, López-Otín, Carlos, additional, Luo, Liu-Ying, additional, Lupas, Andrei, additional, MacKay, Vivian L., additional, Mains, Richard E., additional, Mäkinen, Kauko K., additional, Mäkinen, Pirkko-Liisa, additional, Mandelbaum, Fajga R., additional, Manning, James M., additional, Marcotrigiano, Joseph, additional, Markland, Francis S., additional, Maruyama, M., additional, Maruyama, Sususmu, additional, Masaki, Takeharu, additional, Mathew, Zacharia, additional, Matrisian, Lynn M., additional, Matsuda, Yoshihiro, additional, Matsuka, Yury V., additional, Matsushita, Osamu, additional, Matsuzawa, Hiroshi, additional, Maurizi, Michael R., additional, Mbikay, Majambu, additional, Ken McDonald, J., additional, McKerrow, James H., additional, McMillan, David, additional, Mecham, Robert P., additional, Mehta, Darshini P., additional, Meighan, Paul, additional, Mellors, Alan, additional, Melton, Roger G., additional, Ménard, Armelle, additional, Ménard, Robert, additional, Menéndez-Arias, Luis, additional, Meyer, Diane H., additional, Meyers, Gregor, additional, Michaelis, Susan, additional, Mielicki, Wojciech P., additional, Mierau, Igor, additional, Millán-Pérez-Peña, Lourdes, additional, Miller, Charles G., additional, Mills, John, additional, Mills, Kenneth V., additional, Mistou, Michel-Yves, additional, Misumi, Yoshio, additional, Miyoshi, Shin-ichi, additional, Mizutani, Shigehiko, additional, Mock, William L., additional, Möhrlen, Frank, additional, Moiré, Nathalie, additional, Monnet, Véronique, additional, Monod, Michel, additional, Montecucco, Cesare, additional, Morita, Takashi, additional, Morrissey, James H., additional, Mort, John S., additional, Mortensen, Uffe H., additional, Morty, Rory E., additional, Motoshima, Hidemasa, additional, Mottram, Jeremy C., additional, Mundt, Egbert, additional, Murakami, Kazuo, additional, Murakami-Murofushi, Kimiko, additional, Murao, Sawao, additional, Murata, Christina, additional, Murphy, Gillian, additional, Muta, Tatsushi, additional, Mzhavia, Nino, additional, Nagase, Hideaki, additional, Naik, Rajesh R., additional, Nakajima, Nobuyoshi, additional, Nakamura, Hiroyuki, additional, Nakamura, Yukio, additional, Nasmyth, Kim, additional, Navarro-García, Fernando, additional, Netzel-Arnett, Sarah, additional, Nguyen-Distéche, Martine, additional, Nicholson, Donald, additional, Nikai, Toshiaki, additional, Nirasawa, Satoru, additional, Nishii, Wataru, additional, Nishiyama, Makoto, additional, Niven, Gordon W., additional, Nomura, Seiji, additional, Norioka, Shigemi, additional, North, Michael J., additional, Nuss, Donald L., additional, O′Connor, Michael B., additional, Oberst, Michael, additional, Oda, Kohei, additional, Odorico, Dimitri M., additional, Oetjen, Joyce, additional, Ogura, Teru, additional, Ohkubo, Iwao, additional, Ohlendorf, Douglas H., additional, Ohman, Dennis E., additional, Ohsumi, Yoshinori, additional, Okabe, Akinobu, additional, Okuda, K., additional, Olesen, Kjeld, additional, Oroszlan, Stephen, additional, Orth, Kim, additional, Ota, Nobuyuki, additional, Ovadia, Michael, additional, Overgaard, Michael T., additional, O-Wang, Jiyang, additional, Oxvig, Claus, additional, Packer, Jeremy C.L., additional, Paetzel, Mark, additional, Paine, Mark J.I., additional, Park, John E., additional, Woo Park, Pyong, additional, Soo Park, Sung, additional, Parkin, Kirk L., additional, Parks, William C., additional, Pascall, John C., additional, Paschos, Athanasios, additional, Paul, Sudhir, additional, Pearce, David A., additional, Pei, Duanqing, additional, Pemberton, Alan D., additional, Peters, Jan-Michael, additional, Phylip, Lowri H., additional, Pichová, Iva, additional, Pieper, Michael, additional, Piesse, Christophe, additional, Pike, Rob, additional, Pinck, Lothaire, additional, Pirzad, Ramin, additional, Pitot, Henry C., additional, Plaut, Andrew G., additional, Polgár, László, additional, Postina, Rolf, additional, Potempa, Jan, additional, Poulsen, Knud, additional, Pritchard, David G., additional, Pshezhetsky, Alexey V., additional, Abul Qasim, M., additional, Rader, Stephen D., additional, Rando, Robert R., additional, Rao, Mala, additional, Rao, Narayanam V., additional, Ratnoff, Oscar D., additional, Rawlings, Neil D., additional, Rawson, Robert B., additional, Reddy, Vijay, additional, Redman, Colvin M., additional, Reichl (Deceased), Antonia P., additional, Reid, Julian R., additional, Reid, Kenneth B.M., additional, Remaut, Han, additional, James Remington, S., additional, Rettig, Wolfgang J., additional, Rholam, Mohamed, additional, Rice, Charles M., additional, Richter, Stefan, additional, Riezman, Howard, additional, Ritchie, Alison, additional, Ro, Hyo-Sung, additional, Robert-Baudouy, Janine, additional, Michael Roberts, R., additional, Robinson, Michael, additional, Rodríguez-Romero, Adela, additional, Rogers, John C., additional, Rosenthal, Philip J., additional, Rose, A.M., additional, Rosing, J., additional, Rossetto, Ornella, additional, Rossi, Cesare, additional, Rossi, Véronique, additional, Roth, Richard A., additional, Rowan, Andrew D., additional, Rozanov, Mikhail, additional, Rucavado, Alexandra, additional, Rul, Françoise, additional, Rümenapf, Tillmann, additional, Ryan, Martin D., additional, Ryan, Thomas J., additional, Sacco, Elena, additional, Evan Sadler, J., additional, Saenger, W., additional, Sahl, Hans-Georg, additional, Sajid, Mohammed, additional, Sakiyama, Fumio, additional, Salas, María L., additional, Salter, Jason P., additional, Salvesen, Guy S., additional, Sanchez, Eladio F., additional, Sang, Qing-Xiang Amy, additional, Sankaran, Krishnan, additional, Sarras, Michael P., additional, Sasagawa, Yoshikiyo, additional, Satoh, Kimiyuki, additional, Sauer, Robert T., additional, Sawada, Hitoshi, additional, Scarisbrick, I.A., additional, Schauer-Vukasinovic, Vesna, additional, Schlievert, Patrick M., additional, Schlösser, Manfred, additional, Schmidt, Amy E., additional, Schmidt, Brian F., additional, Schmidt, Walter K., additional, Schmitz, Udo K., additional, Schneemann, Anette, additional, Scholze, Henning, additional, Schomburg, Lutz, additional, Schwaeble, Wilhelm J., additional, Sedlacek, Radislav, additional, Seemüller, Erika, additional, Seidah, Nabil G., additional, Seiki, Motoharu, additional, Selistre de Araujo, Heloisa S., additional, Senior, Robert M., additional, Sik Seong, Ihn, additional, Serpe, Mihaela, additional, Serrano, Solange M.T., additional, Setlow, Peter, additional, Shanks, M., additional, Shao, Feng, additional, Shapiro, Steven D., additional, Shen, Lei, additional, Sherwood (Deceased), Roger F., additional, Shi, Yun-Bo, additional, Shimoi, Hitoshi, additional, Shinoda, Sumio, additional, Siigur, Ene, additional, Siigur, Jüri, additional, Sim, Robert B., additional, Simmer, James P., additional, Simmons, William H., additional, Sirakova, Tatiana D., additional, Skern, Tim, additional, Skidgel, Randal A., additional, Slack, Jeffrey, additional, Sleat, David E., additional, Smith, Janet L., additional, Smyth, Mark J., additional, Snijder, Eric J., additional, Söderhäll, Kenneth, additional, Sohar, Istvan, additional, Sorimachi, Hiroyuki, additional, Sottrup-Jensen, Lars, additional, Soubrier, Florent, additional, Soukhodolets, Karen E., additional, Springman, Eric B., additional, Geme, Joseph W. St., additional, Leger, Raymond J. St., additional, Steele, James L., additional, Steinkühler, Christian, additional, Stenberg, Leisa M., additional, Stenflo, Johan, additional, Stennicke, Henning R., additional, Stepanov (Deceased), Valentin M., additional, Steven, Frank, additional, Stevenson, Kenneth J., additional, Stewart, David J., additional, Storer, Andrew C., additional, Stover, Cordula, additional, Sträter, Norbert, additional, Strauss, Ellen G., additional, Strauss, James H., additional, Stöcker, Walter, additional, Stříšovský, Kvido, additional, Suárez-Rendueles, Paz, additional, Sugimoto, Manabu, additional, Sulea, Traian, additional, Suzuki, Fumiaki, additional, Suzuki, Hideyuki, additional, Swenson, Stephen, additional, Szecsi, Pal B., additional, Szilágyi, László, additional, Taha, Muhamed-Kheir, additional, Takahashi, Kenji, additional, Takio, Koji, additional, Tamura, Tomohiro, additional, Tan, Fulong, additional, Hong Tan, Nget, additional, Tanase, Carmen, additional, Tang, Jordan, additional, Tanizaki, Martha M., additional, Tannich, Egbert, additional, Tans, G., additional, Tarentino (Deceased), Anthony L., additional, Tatnell, Peter J., additional, Tatsumi, Hiroki, additional, Tautz, Norbert, additional, Templin, Markus F., additional, Terada, Shigeyuki, additional, Thacker, C., additional, Theodoratou, Ekaterini, additional, Thiel, Heinz-Jürgen, additional, Thielens, Nicole M., additional, Thierry, Gonzales, additional, Thomas, Mark D., additional, Thornberry, Nancy A., additional, Thorsness, Mary K., additional, Thorsness, Peter E., additional, Tigue, Natalie J., additional, Tjalsma, Harold, additional, Tomkinson, Birgitta, additional, Tonello, Fiorella, additional, Toogood, H.S., additional, Toombs, Christopher, additional, Tortora, Paolo, additional, Tözsér, József, additional, Travis, James, additional, Tschesche, Harald, additional, Tsujimoto, Masafumi, additional, Tsunasawa, Susumu, additional, Tsu, Christopher A., additional, Tu, Anthony T., additional, Turk, Boris, additional, Turk, Dusan, additional, Turk, Vito, additional, Turner, Anthony J., additional, Uchikoba, Tetsuya, additional, Uitto, Veli-Jukka, additional, Ullmann, Dirk, additional, Valdenaire, Olivier, additional, Van Beeumen, Jozef, additional, Van de Ven, Wim J.M., additional, van den Burg, Bertus, additional, Maarten van Dijl, Jan, additional, van Roosmalen, Maarten L., additional, Van Wart, Harold E., additional, Vanoni, Marco, additional, Vath, Gregory M., additional, Velasco, Gloria, additional, Vendrell, Josep, additional, Venekei, István, additional, Vera, Pablo, additional, Verchot-Lubicz, Jeanmarie, additional, Vines, Richard R., additional, Volanakis, John E., additional, Wagner, Fred W., additional, Wainwright, Shane W., additional, Walker, Kenneth W., additional, Walker, Stephen J., additional, Wallach, Jean, additional, Walling, Linda L., additional, Walsh, Peter N., additional, Wang, P., additional, May Wang, Q., additional, Wassenaar, Alfred L.M., additional, Watts, Aaron B., additional, Weber, Joseph M., additional, Webster, Daniel R., additional, Weiss, Stephen J., additional, Wells, James A., additional, Wenzel, Herbert, additional, Wewer, Ulla M., additional, White, Judith M., additional, Wilk, Sherwin, additional, Wilkin, Jean-Marc, additional, Wilkins, Tracy D., additional, Wilkinson, Keith D., additional, Winther, Jakob R., additional, Wlodawer, Alexander, additional, Fred Woessner, J., additional, Wolfe, Michael S., additional, Wolfsberg, Tyra G., additional, Woodgate, Roger, additional, Wright, G.D., additional, Wu, Qingyu, additional, Xie, Sancai, additional, Yamagami, Kenjiro, additional, Yamaguchi, Nozomi, additional, Yamakawa, Yoshio, additional, Yamamoto, Kei, additional, Yamamoto, Shigeo, additional, Yana, Ikuo, additional, Yang, Maozhou, additional, Yasuda, Noriko, additional, Yasuhara, Toshimasa, additional, Yasumasu, Shigeki, additional, Yi, Elizabeth, additional, Yiallouros, Irene, additional, Yonezawa, Hiroo, additional, Ji Yoo, Soon, additional, Yoshimoto, Tadashi, additional, Young, Michael W., additional, Young, Stephen G., additional, Zavalova, Ludmila L., additional, Zdanov, Alexander, additional, and Zhang, Hong-Zhong, additional

Published
2004
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166. Infections à Haemophilus influenzae

Author

Deghmane, Ala-Eddine, Taha, Muhamed-Kheir, Centre Collaborateur de l'OMS pour les méningites bactériennes - WHO Collaborating Center Bacterial Meningitis (CC-OMS - WHO-CC), Institut Pasteur [Paris]-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), and Institut Pasteur [Paris] (IP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)

Subjects
Non typable, Infection, Haemophilus influenzae, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Sérotype
Abstract

Attention DOI éditeur non valide au 17/06/21; International audience; Haemophilus influenzae est une bactérie sous forme de coccobacille à Gram négatif dont l'homme est le seul hôte naturel connu. Cette bactérie colonise fréquemment les voies respiratoires chez l'être humain comme constituant de la flore normale des humains. La transmission est aérogène et le portage rhinopharyngé est généralement asymptomatique. Les infections invasives à H. influenzae se produisent lorsque la bactérie traverse le rhinopharynx, envahit la circulation sanguine et se propage pour atteindre des sites normalement stériles. Les infections invasives à H. influenzae peuvent se manifester comme une septicémie, une pneumonie invasive, une épiglottite et une méningite bactérienne aiguë. H. influenzae est divisé en deux grandes catégories : souches capsulées et non capsulées. La capsule détermine le sérotype et c'est le sérotype b (H. influenzae b) qui est le plus pathogène chez l'homme, affectant principalement les nourrissons et les jeunes enfants. Au début des années 1990, le vaccin conjugué contre le sérotype b a été introduit dans la plupart des pays européens, et l'incidence des infections invasives à H. influenzae b a considérablement baissé. Les autres sérotypes (a, c, d, e et f) restent rarement associées aux infections invasives et peuvent révéler des comorbidités subjacentes. Les souches non capsulées sont également appelées « non typables » (H. influenzae NT). Elles causent habituellement des infections non invasives des voies respiratoires supérieures, telles que l'otite moyenne et la sinusite. Cependant, les souches H. influenzae NT peuvent être responsables d'infections invasives.

Published
2019
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167. Updates from the Global Meningococcal Initiative in Eastern Europe

Author

Bai, Xilian, Borrow, Ray, Bukovski, Suzana, Caugant, Dominique A., Culic, Davor, Delic, Snezana, Dinleyici, Ener Cagri, Eloshvili, Medeia, Erdősi, Tímea, Galajeva, Jelena, Křížová, Pavla, Lucidarme, Jay, Mironov, Konstantin, Nurmatov, Zuridin, Pana, Marina, Rahimov, Erkin, Savrasova, Larisa, Skoczyńska, Anna, Smith, Vinny, Taha, Muhamed-Kheir, Titov, Leonid, Vázquez, Julio, and Yeraliyeva, Lyazzat

Subjects
Antibiotic resistance Bacterial meningitis Conjugate vaccine Easter Europe
Abstract

The Global Meningococcal Initiative (GMI) aims to prevent invasive meningococcal disease (IMD) worldwide through education, research and cooperation. In March 2019, a GMI meeting was held with a multidisciplinary group of experts and representatives from countries within Eastern Europe. Across the countries represented, IMD surveillance is largely in place, with incidence declining in recent decades and now generally at

Published
2019

168. Genetic Meningococcal Antigen Typing System (gMATS): A genotyping tool that predicts 4CMenB strain coverage worldwide

Author

Muzzi, Alessandro Brozzi, Alessandro Serino, Laura Bodini, Margherita Abad, Raquel Caugant, Dominique Comanducci, Maurizio Lemos, Ana Paula Gorla, Maria Cecilia Krizova, Pavla Mikula, Claudia Mulhall, Robert Nissen, Michael and Nohynek, Hanna Simoes, Maria Joao Skoczynska, Anna and Stefanelli, Paola Taha, Muhamed-Kheir Toropainen, Maija and Tzanakaki, Georgina Vadivelu-Pechai, Kumaran Watson, Philip and Vazquez, Julio A. Rajam, Gowrisankar Rappuoli, Rino Borrow, Ray Medini, Duccio

Abstract

Background: The Meningococcal Antigen Typing System (MATS) was developed to identify meningococcus group B strains with a high likelihood of being covered by the 4CMenB vaccine, but is limited by the requirement for viable isolates from culture-confirmed cases. We examined if antigen genotyping could complement MATS in predicting strain coverage by the 4CMenB vaccine. Methods: From a panel of 3912 MATS-typed invasive meningococcal disease isolates collected in England and Wales in 2007-2008, 2014-2015 and 2015-2016, and in 16 other countries in 2000-2015, 3481 isolates were also characterized by antigen genotyping. Individual associations between antigen genotypes and MATS coverage for each 4CMenB component were used to define a genetic MATS (gMATS). gMATS estimates were compared with England and Wales human complement serum bactericidal assay (hSBA) data and vaccine effectiveness (VE) data from England. Results: Overall, 81% of the strain panel had genetically predictable MATS coverage, with 92% accuracy and highly concordant results across national panels (Lin’s accuracy coefficient, 0.98; root-mean square deviation, 6%). England and Wales strain coverage estimates were 72-73% by genotyping (66-73% by MATS), underestimating hSBA values after four vaccine doses (88%) and VE after two doses (83%). The gMATS predicted strain coverage in other countries was 58-88%. Conclusions: gMATS can replace MATS in predicting 4CMenB strain coverage in four out of five cases, without requiring a cultivable isolate, and is open to further improvement. Both methods underestimated VE in England. Strain coverage predictions in other countries matched or exceeded England and Wales estimates. (C) 2019 GlaxoSmithKline Biologicals SA. Published by Elsevier Ltd.

Published
2019

172. Travel-related Neisseria meningitidis serogroup w135 infection, France

Author

Taha, Muhamed-Kheir, Kacou-NDouba, Adele, Hong, Eva, Deghmane, Ala Eddine, Giorgini, Dario, Okpo, Sophia Lurette, Kangah, Tatiana, and Dosso, Mireille

Subjects
Sub-Saharan Africa -- Health aspects, Neisseria meningitidis -- Case studies -- Statistics, Travelers -- Health aspects, Disease transmission -- Research, Meningitis, Cerebrospinal -- Case studies -- Risk factors, Health
Abstract

To the Editor: A multinational outbreak of infection with Neisseria meningitidis serogroup W135 belonging to the sequence type (ST) 11 clonal complex started in the year 2000 among pilgrims to [...]

Published
2013

173. Control of Neisseria gonorrhoeae pilin gene expression by environmental factors: involvement of the pilA/pilB regulatory genes

Author

Larribe, Mireille, Taha, Muhamed-Kheir, Topilko, Andrzej, and Marchal, Christian

Subjects
Neisseria gonorrhoeae -- Genetic aspects, Genetic transcription -- Regulation, Genetic regulation -- Research, Microbial genetics -- Research, Biological sciences
Abstract

The effects of different growth conditions on the expression of the Neisseria gonorrhoeae pilin (pilE) gene were analyzed by utilizing gene fusions between pilE and the chloramphenicol acetyltransferase (CAT) gene. Analysis of pilE gene expression patterns via pilE-CAT gene fusions in the presence of high osmolality, high urea concentration and anaerobiosis indicated the role of PilA and PilB in mediating environmental adaptations. The PilA/PilB regulatory proteins also exhibited pleiotropic effects on the level of several gonococcal proteins.

Published
1997

175. The Global Meningococcal Initiative meeting on prevention of meningococcal disease worldwide : Epidemiology, surveillance, hypervirulent strains, antibiotic resistance and high-risk populations

Author

Acevedo, Reinaldo, Bai, Xilian, Borrow, Ray, Caugant, Dominique A., Carlos, Josefina, Ceyhan, Mehmet, Christensen, Hannah, Climent, Yanet, De Wals, Philippe, Dinleyici, Ener Cagri, Echaniz-Aviles, Gabriela, Hakawi, Ahmed, Kamiya, Hajime, Karachaliou, Andromachi, Lucidarme, Jay, Meiring, Susan, Mironov, Konstantin, Safadi, Marco A. P., Shao, Zhujun, Smith, Vinny, Steffen, Robert, Stenmark, Bianca, Taha, Muhamed-Kheir, Trotter, Caroline, Vazquez, Julio A., Zhu, Bingqing, Acevedo, Reinaldo, Bai, Xilian, Borrow, Ray, Caugant, Dominique A., Carlos, Josefina, Ceyhan, Mehmet, Christensen, Hannah, Climent, Yanet, De Wals, Philippe, Dinleyici, Ener Cagri, Echaniz-Aviles, Gabriela, Hakawi, Ahmed, Kamiya, Hajime, Karachaliou, Andromachi, Lucidarme, Jay, Meiring, Susan, Mironov, Konstantin, Safadi, Marco A. P., Shao, Zhujun, Smith, Vinny, Steffen, Robert, Stenmark, Bianca, Taha, Muhamed-Kheir, Trotter, Caroline, Vazquez, Julio A., and Zhu, Bingqing

Abstract

Introduction: The 2018 Global Meningococcal Initiative (GMI) meeting focused on evolving invasive meningococcal disease (IMD) epidemiology, surveillance, and protection strategies worldwide, with emphasis on emerging antibiotic resistance and protection of high-risk populations. The GMI is comprised of a multidisciplinary group of scientists and clinicians representing institutions from several continents. Areas covered: Given that the incidence and prevalence of IMD continually varies both geographically and temporally, and surveillance systems differ worldwide, the true burden of IMD remains unknown. Genomic alterations may increase the epidemic potential of meningococcal strains. Vaccination and (to a lesser extent) antimicrobial prophylaxis are the mainstays of IMD prevention. Experiences from across the globe advocate the use of conjugate vaccines, with promising evidence growing for protein vaccines. Multivalent vaccines can broaden protection against IMD. Application of protection strategies to high-risk groups, including individuals with asplenia, complement deficiencies and human immunodeficiency virus, laboratory workers, persons receiving eculizumab, and men who have sex with men, as well as attendees at mass gatherings, may prevent outbreaks. There was, however, evidence that reduced susceptibility to antibiotics was increasing worldwide. Expert commentary: The current GMI global recommendations were reinforced, with several other global initiatives underway to support IMD protection and prevention., Funding Agency:Sanofi Pasteur

Published
2019
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180. Lactobacillus paracasei feeding improves immune control of influenza infection in mice

Author

Belkacem, Nouria, Serafini, Nicolas, Wheeler, Richard, Derrien, Muriel, Boucinha, Lilia, Couesnon, Aurélie, Cerf-Bensussan, Nadine, Gomperts Boneca, Ivo, Di Santo, James, Taha, Muhamed-Kheir, Bourdet-Sicard, Raphaelle, Sun, Jie, Infections Bactériennes Invasives, Institut Pasteur [Paris], Immunité Innée - Innate Immunity, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall (BGPB), Danone Nutricia Research, BIOASTER Microbiology Technology Institute [Lyon], Laboratory of Intestinal Immunity (Equipe Inserm U1163), Imagine - Institut des maladies génétiques (IMAGINE - U1163), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR), Danone Research, Groupe DANONE, The study was supported by the following grants: CI IMMUNOBIOTIC 1307014/00 IRT BAP301, Danone 30000221 as well as by the Institut Pasteur. In addition to funding, Danone Nutricia Research and Bioaster provided coordination and management. In addition, Danone Nutricia Research made available Lactobacilli strains and performed Microbiota analysis. The funders had no role in study design, decision to publish, or preparation of the manuscript. MD and RBS are employed by Danone Nutricia Research. Danone Nutricia Research provided support in the form of salaries for authors MD and RBS, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘author contributions’ section., Institut Pasteur [Paris] (IP), Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), and TAHA, Muhamed-Kheir

Subjects
Bacterial Diseases, Viral Diseases, Physiology, Polymers, MESH: Orthomyxoviridae Infections/immunology, Colony Count, Microbial, lcsh:Medicine, MESH: Orthomyxoviridae/immunology, Pathology and Laboratory Medicine, Mice, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Immune Physiology, Medicine and Health Sciences, MESH: Orthomyxoviridae Infections/prevention & control, MESH: Animals, MESH: Respiratory Tract Infections/prevention & control, lcsh:Science, Immune Response, Respiratory Tract Infections, Innate Immune System, Immunity, Cellular, Mice, Inbred BALB C, food and beverages, Animal Models, Lacticaseibacillus paracasei, Orthomyxoviridae, Chemistry, Infectious Diseases, Experimental Organism Systems, Macromolecules, Physical Sciences, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Cytokines, Female, Research Article, Infectious Disease Control, Materials by Structure, Immunology, Materials Science, MESH: Mice, Inbred BALB C, Mouse Models, MESH: Probiotics/administration & dosage, Research and Analysis Methods, Microbiology, Model Organisms, Signs and Symptoms, Orthomyxoviridae Infections, Diagnostic Medicine, Virology, Prevotella Infection, Animals, MESH: Colony Count, Microbial, MESH: Mice, MESH: Lactobacillus paracasei/physiology, Inflammation, Probiotics, MESH: Respiratory Tract Infections/microbiology, lcsh:R, Biology and Life Sciences, MESH: Respiratory Tract Infections/immunology, Molecular Development, Peptidoglycans, Polymer Chemistry, Influenza, MESH: Orthomyxoviridae Infections/microbiology, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Immune System, lcsh:Q, MESH: Immunity, Cellular/immunology, MESH: Female, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Viral Transmission and Infection, Developmental Biology
Abstract

International audience; Respiratory tract infections such as flu cause severe morbidity and mortality and are among the leading causes of death in children and adults worldwide. Commensal microbiota is critical for orchestrating tissue homeostasis and immunity in the intestine. Probiotics represent an interesting source of immune modulators and several clinical studies have addressed the potential beneficial effects of probiotics against respiratory infections. Therefore, we have investigated the mechanisms of protection conferred by L. paracasei CNCM I-1518 strain in a mouse model of influenza infection. Notably, local myeloid cells accumulation is generated in the lungs after seven days feeding with L. paracasei prior to viral infection. L. paracasei-fed mice showed reduced susceptibility to the influenza infection, associated with less accumulation of inflammatory cells in the lungs, faster viral clearance and general health improvement. Interestingly, Allobaculum was significantly increased in L. paracasei-fed mice 7 days after influenza infection, even if the gut microbiota composition was not altered overall. L. paracasei-purified peptidoglycan partially recapitulated the protective phenotype observed with the entire bacteria. Collectively, our results demonstrate that oral consumption of L. paracasei CNCM I-1518 modulates lung immunity was associated with an improved control of influenza infection. These results further extend the beneficial role for certain lactobacilli to alleviate the burden of respiratory tract infections.

Published
2017
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185. Characterization of meningococcal carriage isolates from Greece by whole genome sequencing: Implications for 4CMenB vaccine implementation

Author

Kesanopoulos, Konstantinos Bratcher, Holly B. Hong, Eva and Xirogianni, Athanasia Papandreou, Anastasia Taha, Muhamed-Kheir and Maiden, Martin C. J. Tzanakaki, Georgina

Abstract

Herd protection, resulting from the interruption of transmission and asymptomatic carriage, is an important element of the effectiveness of vaccines against the meningococcus. Whilst this has been well established for conjugate polysaccharide vaccines directed against the meningococcal capsule, two uncertainties surround the potential herd protection provided by the novel protein-based vaccines that are used in place of serogroup B (MenB) polysaccharide vaccines (i) the strain coverage of such vaccines against carried meningococci, which are highly diverse; and (ii) the generation of a protective immune response in the mucosa. These considerations are essential for realistic estimates of cost-effectiveness of new MenB vaccines. Here the first of these questions is addressed by the whole genome sequence (WGS) analysis of meningococci isolated from healthy military recruits and university students in Greece. The study included a total of 71 MenB isolates obtained from 1420 oropharyngeal single swab samples collected from military recruits and university students on voluntary basis, aged 18-26 years. In addition to WGS analysis to identify genetic lineage and vaccine antigen genes, including the Bexsero Antigen Sequence Type (BAST), the isolates were examined with the serological Meningococcal antigen Typing System (MATS) assay. Comparison of these data demonstrated that the carried meningococcal population was highly diverse with 38% of the carriage isolates showed expression of antigens matching those included in the 4CMenB vaccine. Our data may suggest a limited potential herd immunity to be expected and be driven by an impact on a subset of carriage isolates.

Published
2018

186. Author response: Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis

Author

Williams, Allison Hillary, primary, Wheeler, Richard, additional, Deghmane, Ala-Eddine, additional, Santecchia, Ignacio, additional, Schaub, Ryan E, additional, Hicham, Samia, additional, Moya Nilges, Maryse, additional, Malosse, Christian, additional, Chamot-Rooke, Julia, additional, Haouz, Ahmed, additional, Dillard, Joseph P, additional, Robins, William P, additional, Taha, Muhamed-Kheir, additional, and Gomperts Boneca, Ivo, additional

Published
2019
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187. Clinical and Genetic Spectrum of a Large Cohort With Total and Sub-total Complement Deficiencies

Author

El Sissy, Carine, primary, Rosain, Jérémie, additional, Vieira-Martins, Paula, additional, Bordereau, Pauline, additional, Gruber, Aurélia, additional, Devriese, Magali, additional, de Pontual, Loïc, additional, Taha, Muhamed-Kheir, additional, Fieschi, Claire, additional, Picard, Capucine, additional, and Frémeaux-Bacchi, Véronique, additional

Published
2019
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188. Crippling the bacterial cell wall molecular machinery

Author

Williams, Allison H., primary, Wheeler, Richard, additional, Deghmane, Ala-Eddine, additional, Santecchia, Ignacio, additional, Impens, Francis, additional, Bastos, Paulo André Dias, additional, Hicham, Samia, additional, Nilges, Maryse Moya, additional, Malosse, Christian, additional, Chamot-Rooke, Julia, additional, Haouz, Ahmed, additional, Robins, William P., additional, Taha, Muhamed-Kheir, additional, and Boneca, Ivo Gomperts, additional

Published
2019
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189. Genetic Meningococcal Antigen Typing System (gMATS): A genotyping tool that predicts 4CMenB strain coverage worldwide

Author

Muzzi, Alessandro, primary, Brozzi, Alessandro, additional, Serino, Laura, additional, Bodini, Margherita, additional, Abad, Raquel, additional, Caugant, Dominique, additional, Comanducci, Maurizio, additional, Lemos, Ana Paula, additional, Gorla, Maria Cecilia, additional, Křížová, Pavla, additional, Mikula, Claudia, additional, Mulhall, Robert, additional, Nissen, Michael, additional, Nohynek, Hanna, additional, Simões, Maria João, additional, Skoczyńska, Anna, additional, Stefanelli, Paola, additional, Taha, Muhamed-Kheir, additional, Toropainen, Maija, additional, Tzanakaki, Georgina, additional, Vadivelu-Pechai, Kumaran, additional, Watson, Philip, additional, Vazquez, Julio A., additional, Rajam, Gowrisankar, additional, Rappuoli, Rino, additional, Borrow, Ray, additional, and Medini, Duccio, additional

Published
2019
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194. Polymerase chain reaction assay and bacterial meningitis surveillance in remote areas, Niger

Author

Sidikou, Fati, Djibo, Saacou, Taha, Muhamed Kheir, Alonso, Jean Michel, Djibo, Ali, Kairo, Kiari Kaka, Chanteau, Suzanne, and Boisier, Pascal

Subjects
Meningitis -- Research, Meningitis -- Diagnosis
Abstract

To compensate for the lack of laboratories in remote areas, the national reference Laboratory for meningitis in Niger used polymerase chain reaction (PCR) to enhance the surveillance of meningitis caused [...]

Published
2003

195. Recent increase in meningitis caused by Neisseria meningitidis serogroups A and W135, Yaounde, Cameroon. (Dispatches)

Author

Fonkoua, Marie-Christine, Taha, Muhamed-Kheir, Nicolas, Pierre, Cunin, Patrick, Alonso, Jean-Michel, Bercion, Raymond, Musi, Jeanne, and Martin, Paul M.V.

Subjects
Meningitis -- Physiological aspects, Neisseria meningitidis -- Identification and classification, Communicable diseases -- Surveys
Abstract

From 1991 to 1998, Neisseria meningitidis serogroups A, B, and C represented 2%-10% of strains isolated from cases of bacterial meningitis in Yaounde During 1999 to 2000, the percentage of [...]

Published
2002

196. A Review of the Epidemiology of Invasive Meningococcal Disease and Vaccination Strategies in North Africa.

Author

Taha, Muhamed-Kheir, Presa, Jessica, and Serra, Lidia

Subjects
*MENINGOCOCCAL vaccines, *MENINGOCOCCAL infections, *BACTERIAL meningitis, *ENDEMIC diseases, *EPIDEMIOLOGY, *NEISSERIA meningitidis
Abstract

• Invasive meningococcal disease (IMD) is notifiable in most North African countries. • Most countries in the region have insufficient or no surveillance systems in place. • IMD cases in North Africa were most frequently found in children aged <5 years. • Overall, IMD cases in North Africa were dominated by serogroup B. This narrative review considers the epidemiology of invasive meningococcal disease (IMD) in North Africa and the adequacy of current preventive measures to provide guidance for future vaccination strategies. Literature searches were conducted using PubMed for articles published from 1998 onwards to identify publications on IMD in North Africa. Additional relevant articles not included within the search results and data sources were identified from the reference lists of identified publications, authors' personal files, and publicly available government or regional surveillance data. Although IMD is an endemic and notifiable disease in several North African countries, inadequacies exist regarding each country's surveillance, vaccination strategies, and disease understanding. Studies showed bacterial meningitis in North Africa caused by Neisseria meningitidis mostly affects young children (aged <5 years), with meningococcal serogroup B (MenB) being the most frequently identified serotype. Importantly, MenB isolates were genetically heterogeneous. Serogroup A incidence and meningococcal outbreaks decreased over time in Morocco and Egypt, possibly because of their nationwide or school-based vaccination programs. Within the region, meningococcal vaccines are only included in the national immunization program of Egypt. Improving IMD diagnosis and surveillance would provide a reliable estimate of IMD burden, leading to better vaccination strategies. [ABSTRACT FROM AUTHOR]

Published
2021
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198. The Global Meningococcal Initiative: global epidemiology, the impact of vaccines on meningococcal disease and the importance of herd protection

Author

Borrow, Ray, Alarcón, Pedro, Carlos, Josefina, Caugant, Dominique A, Christensen, Hannah, Debbag, Roberto, De Wals, Philippe, Echániz-Aviles, Gabriela, Findlow, Jamie, Head, Chris, Holt, Daphne, Kamiya, Hajime, Saha, Samir K, Sidorenko, Sergey, Taha, Muhamed-Kheir, Trotter, Caroline, Vázquez Moreno, Julio A, Von Gottberg, Anne, Sáfadi, Marco AP, Global Meningococcal Initiative, Trotter, Caroline [0000-0003-4000-2708], and Apollo - University of Cambridge Repository

Subjects
meningococcal disease, Vaccines, Conjugate, Global Meningococcal Initiative, Epidemiology, Immunization Programs, Incidence, Meningococcal Vaccines, Neisseria meningitidis, Meningitis, Meningococcal, vaccination, Global Health, Disease Outbreaks, Meningococcal Infections, prevention, outbreaks, surveillance, Humans, MenW, serogroups
Abstract

The 2015 Global Meningococcal Initiative (GMI) meeting discussed the global importance of meningococcal disease (MD) and its continually changing epidemiology. Areas covered: Although recent vaccination programs have been successful in reducing incidence in many countries (e.g. Neisseria meningitidis serogroup [Men]C in Brazil, MenA in the African meningitis belt), new clones have emerged, causing outbreaks (e.g. MenW in South America, MenC in Nigeria and Niger). The importance of herd protection was highlighted, emphasizing the need for high vaccination uptake among those with the highest carriage rates, as was the need for boosters to maintain individual and herd protection following decline of immune response after primary immunization. Expert commentary: The GMI Global Recommendations for Meningococcal Disease were updated to include a recommendation to enable access to whole-genome sequencing as for surveillance, guidance on strain typing to guide use of subcapsular vaccines, and recognition of the importance of advocacy and awareness campaigns.

Published
2017

199. Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases

Author

Williams, Allison H., Wheeler, Richard, Thiriau, Constance, Haouz, Ahmed, Taha, Muhamed-Kheir, Boneca, Ivo, Biologie et Génétique de la Paroi bactérienne - Biology and Genetics of Bacterial Cell Wall (BGPB), Institut Pasteur [Paris], Groupe Avenir, Institut National de la Santé et de la Recherche Médicale (INSERM), Cristallographie (Plateforme) - Crystallography (Platform), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Infections Bactériennes Invasives, This work was supported by an ERC starting grant (PGNfromSHAPEtoVIR 202283) to Ivo Gomperts Boneca and an ANR (Agence National de la Recherche) grant number ANR-14-CE14-0003 to MKT. This study has received funding from the French Government′s Investissement d′Avenir program, Laboratoire d′Excellence 'Integrative Biology of Emerging Infectious Diseases' (grant n°ANR-10-LABX-62-IBEID)., ANR-14-CE14-0003,ORBiMP,Déjouer la résistance aux beta-lactamines des méningocoques et pneumocoques(2014), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris] (IP), and Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Neisseria, bulgecin, lytic transglycosylase, beta‐lactam, peptidoglycan, beta-lactam, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Article
Abstract

International audience; Lytic transglycosylases (Lts) are involved in recycling, cell division, and metabolism of the peptidoglycan. They have been understudied for their usefulness as potential antibacterial targets due to their high redundancy in Gram-negative bacteria. Bulgecin A is an O-sulphonated glycopeptide that targets primarily soluble lytic tranglycosylases (Slt). It has been shown that bulgecin A increases the efficacy of β-lactams that target penicillin bindings proteins (PBPs). Here, we present the high-resolution crystal structure of LtgA from Neisseria meningitidis strain MC58, a membrane bound homolog of Escherichia coli Slt, in complex with bulgecin A. The LtgA-bulgecin A complex reveals the mechanism of inhibition by bulgecin A at near atomic resolution. We further demonstrate that bulgecin A is not only a potent inhibitor of LtgA, but most importantly, it restores the efficacy of β-lactam antibiotics in strains of N. meningitidis and Neisseria gonorrhoeae that have reduced susceptibility to β-lactams. This is particularly relevant for N. gonorrhoeae where no vaccines are available. This work illustrates how best to target dangerous pathogens using a multiple drug target approach, a new and alternative approach to fighting antibiotic resistance.

Published
2017
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200. Meningococcal Disease In The Middle East And Africa: Findings And Updates From The Global Meningococcal Initiative

Author

Borrow, Ray, Caugant, Dominique A., Ceyhan, Mehmet, Christensen, Hannah, Dinleyici, Ener Cagri, Findlow, Jamie, Glennie, Linda, Von Gottberg, Anne, Kechrid, Amel, Vazquez Moreno, Julio, Razki, Aziza, Smith, Vincent, Taha, Muhamed-Kheir, Tali-Maamar, Hassiba, Zerouali, Khalid, and İç Hastalıkları

Subjects
Infectious Diseases
Abstract

The Global Meningococcal Initiative (GMI) has recently considered current issues in Middle Eastern and African countries, and produced two recommendations: (i) that vaccination of attendees should be considered for some types of mass-gathering events, as some countries mandate for the Hajj, and (ii) vaccination of people with human immunodeficiency virus should be used routinely, because of increased meningococcal disease (MD) risk. Differences exist between Middle Eastern and African countries regarding case and syndrome definitions, surveillance, and epidemiologic data gaps. Sentinel surveillance provides an overview of trends and prevalence of different capsular groups supporting vaccine selection and planning, whereas cost-effectiveness decisions require comprehensive disease burden data, ideally counting every case. Surveillance data showed importance of serogroup B MD in North Africa and serogroup W expansion in Turkey and South Africa. Success of MenAfriVac (R) in the African "meningitis belt" was reviewed; the GMI believes similar benefits may follow development of a low-cost meningococcal pentavalent vaccine, currently in phase 1 clinical trial, by 2022. The importance of carriage and herd protection for controlling invasive MD and the importance of advocacy and awareness campaigns were also highlighted. (C) 2017 The Authors. Published by Elsevier Ltd on behalf of The British Infection Association.

Published
2017

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