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3,115 results on '"T Baker"'

152. Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive?Behavioral Therapy in Children With Obsessive-Compulsive Disorder

Author

Sara Bertolín, Pino Alonso, Ignacio Martínez-Zalacaín, Jose M. Menchón, Susana Jimenez-Murcia, Justin T. Baker, Nuria Bargalló, Marcelo Camargo Batistuzzo, Premika S.W. Boedhoe, Brian P. Brennan, Jamie D. Feusner, Kate D. Fitzgerald, Martine Fontaine, Bjarne Hansen, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Neda Jahanshad, Fern Jaspers-Fayer, Masaru Kuno, Gerd Kvale, Luisa Lazaro, Mafalda Machado-Sousa, Rachel Marsh, Pedro Morgado, Akiko Nakagawa, Luke Norman, Erika L. Nurmi, Joseph O’Neill, Ana E. Ortiz, Chris Perriello, John Piacentini, Maria Picó-Pérez, Roseli G. Shavitt, Eiji Shimizu, Helen Blair Simpson, S. Evelyn Stewart, Sophia I. Thomopoulos, Anders Lillevik Thorsen, Susanne Walitza, Lidewij H. Wolters, Paul M. Thompson, Odile A. van den Heuvel, Dan J. Stein, Carles Soriano-Mas, Eva Real, Cinto Segalas, Astrid Morer, Silvia Brem, Sonia Ferreira, Pedro Silva Moreira, Kristen Hagen, Sayo Hamatani, Jumpei Takahashi, Tokiko Yoshida, Maria Alice de Mathis, Euripedes C. Miguel, Jose C. Pariente, Jinsong Tang, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, and Amsterdam Neuroscience - Neurodegeneration

Subjects
Psychiatry and Mental health, Developmental and Educational Psychology
Abstract

Objective: Cognitive-behavioral therapy (CBT) is considered a first-line treatment for obsessive-compulsive disorder (OCD) in pediatric and adult populations. Nevertheless, some patients show partial or null response. The identification of predictors of CBT response may improve clinical management of patients with OCD. Here, we aimed to identify structural magnetic resonance imaging (MRI) predictors of CBT response in 2 large series of children and adults with OCD from the worldwide ENIGMA-OCD consortium. Method: Data from 16 datasets from 13 international sites were included in the study. We assessed which variations in baseline cortical thickness, cortical surface area, and subcortical volume predicted response to CBT (percentage of baseline to post-treatment symptom reduction) in 2 samples totaling 168 children and adolescents (age range 5-17.5 years) and 318 adult patients (age range 18-63 years) with OCD. Mixed linear models with random intercept were used to account for potential cross-site differences in imaging values. Results: Significant results were observed exclusively in the pediatric sample. Right prefrontal cortex thickness was positively associated with the percentage of CBT response. In a post hoc analysis, we observed that the specific changes accounting for this relationship were a higher thickness of the frontal pole and the rostral middle frontal gyrus. We observed no significant effects of age, sex, or medication on our findings. Conclusion: Higher cortical thickness in specific right prefrontal cortex regions may be important for CBT response in children with OCD. Our findings suggest that the right prefrontal cortex plays a relevant role in the mechanisms of action of CBT in children.

Published
2023

154. Supplementary Methods, Supplementary Figure I-IV from Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies

Author

Alan L. Parker, John D. Chester, Richard G. Vile, Emma Hudson, Louise Hanna, Rachel Jones, Pierre J. Rizkallah, Alexander T. Baker, Angela Bradshaw, Kevin G. Shim, Laura Evgin, Phonphimon Wongthida, Jill M. Thompson, James A. Davies, and Hanni Uusi-Kerttula

Abstract

Supplemental Figure I. Homology modelling of the Ad5NULL-A20 complex; Supplement II. Biodistribution study: Heat-map images of luminescence intensity ex vivo; Supplement II. Biodistribution study: Immunohistochemistry on formalin-fixed, paraffinembedded liver sections; Supplementary Figure IV. Pilot study: Tumour localisation and take rate in NOD/SCID mice; Supplement II. Biodistribution study: Immunohistochemistry on formalin-fixed, paraffinembedded; liver sections; Supplementary Figure IV. Pilot study: Tumour localisation and take rate in NOD/SCID mice.

Published
2023

156. Data from Inhibition of HER2 Increases JAGGED1-dependent Breast Cancer Stem Cells: Role for Membrane JAGGED1

Author

Clodia Osipo, Lucio Miele, Alexandra Filipovic, Andrew Green, Emad Rakha, Michelle Fernandez, Daniel S. Peiffer, Patricia Simms, Andrew T. Baker, Debra Wyatt, and Deep Shah

Abstract

Purpose: HER2-positive breast cancer is driven by cells possessing stem-like properties of self-renewal and differentiation, referred to as cancer stem cells (CSC). CSCs are implicated in radiotherapy, chemotherapy resistance, and tumor recurrence. NOTCH promotes breast CSC survival and self-renewal, and overexpression of NOTCH1 and the NOTCH ligand JAGGED1 predict poor outcome. Resistance to anti-HER2 therapy in HER2+ breast cancer requires NOTCH1, and that combination of trastuzumab and a gamma secretase inhibitor (GSI) prevents tumor relapse in xenograft models.Experimental Design: The current study investigates mechanisms by which HER2 tyrosine kinase activity regulates NOTCH-dependent CSC survival and tumor initiation.Results: Lapatinib-mediated HER2 inhibition shifts the population of HER2+ breast cancer cells from low membrane JAGGED1 expression to higher levels, independent of sensitivity to anti-HER2 treatment within the bulk cell population. This increase in membrane JAGGED1 is associated with higher NOTCH receptor expression, activation, and enrichment of CSCs in vitro and in vivo. Importantly, lapatinib treatment results in growth arrest and cell death of JAGGED1 low-expressing cells while the JAGGED1 high-expressing cells continue to cycle. High membrane JAGGED1 protein expression predicts poor overall cumulative survival in women with HER2+ breast cancer.Conclusions: These results indicate that higher membrane JAGGED1 expression may be used to either predict response to anti-HER2 therapy or for detection of NOTCH-sensitive CSCs posttherapy. Sequential blockade of HER2 followed by JAGGED1 or NOTCH could be more effective than simultaneous blockade to prevent drug resistance and tumor progression. Clin Cancer Res; 24(18); 4566–78. ©2018 AACR.

Published
2023

157. Data from Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies

Author

Alan L. Parker, John D. Chester, Richard G. Vile, Emma Hudson, Louise Hanna, Rachel Jones, Pierre J. Rizkallah, Alexander T. Baker, Angela Bradshaw, Kevin G. Shim, Laura Evgin, Phonphimon Wongthida, Jill M. Thompson, James A. Davies, and Hanni Uusi-Kerttula

Abstract

Purpose: Virotherapies are maturing in the clinical setting. Adenoviruses (Ad) are excellent vectors for the manipulability and tolerance of transgenes. Poor tumor selectivity, off-target sequestration, and immune inactivation hamper clinical efficacy. We sought to completely redesign Ad5 into a refined, tumor-selective virotherapy targeted to αvβ6 integrin, which is expressed in a range of aggressively transformed epithelial cancers but nondetectable in healthy tissues.Experimental Design: Ad5NULL-A20 harbors mutations in each major capsid protein to preclude uptake via all native pathways. Tumor-tropism via αvβ6 targeting was achieved by genetic insertion of A20 peptide (NAVPNLRGDLQVLAQKVART) within the fiber knob protein. The vector's selectivity in vitro and in vivo was assessed.Results: The tropism-ablating triple mutation completely blocked all native cell entry pathways of Ad5NULL-A20 via coxsackie and adenovirus receptor (CAR), αvβ3/5 integrins, and coagulation factor 10 (FX). Ad5NULL-A20 efficiently and selectively transduced αvβ6+ cell lines and primary clinical ascites-derived EOC ex vivo, including in the presence of preexisting anti-Ad5 immunity. In vivo biodistribution of Ad5NULL-A20 following systemic delivery in non–tumor-bearing mice was significantly reduced in all off-target organs, including a remarkable 107-fold reduced genome accumulation in the liver compared with Ad5. Tumor uptake, transgene expression, and efficacy were confirmed in a peritoneal SKOV3 xenograft model of human EOC, where oncolytic Ad5NULL-A20–treated animals demonstrated significantly improved survival compared with those treated with oncolytic Ad5.Conclusions: Oncolytic Ad5NULL-A20 virotherapies represent an excellent vector for local and systemic targeting of αvβ6-overexpressing cancers and exciting platforms for tumor-selective overexpression of therapeutic anticancer modalities, including immune checkpoint inhibitors. Clin Cancer Res; 24(17); 4215–24. ©2018 AACR.

Published
2023

158. Broad sialic acid usage amongst species D human adenovirus

Author

Rosie M. Mundy, Alexander T. Baker, Emily A. Bates, Tabitha G. Cunliffe, Alicia Teijeira-Crespo, Elise Moses, Pierre J. Rizkallah, and Alan L. Parker

Abstract

Human adenoviruses (HAdV) are widespread pathogens causing infections of the respiratory and gastrointestinal tracts, genitourinary system and the eye. Species D (HAdV-D) are the most diverse species and cause both gastrointestinal tract infections and epidemic keratoconjunctivitis (EKC). Despite being significant pathogens, HAdV-D are understudied and knowledge around basic mechanisms of cell infection is lacking. Sialic acid (SA) usage has been proposed as a major mechanism of cell infection for EKC causing HAdV-D. Here, we provide apo state crystal structures for fiber knob proteins of 7 previously undetermined HAdV-D, and provide crystal structures of HAdV-D25, HAdV-D29 and HAdV-D53 knob proteins bound to SA. Biologically, we demonstrate that removal of cell surface SA reduced infectivity of HAdV-C5 vectors pseudotyped with HAdV-D fiber knob proteins, whilst engagement of the classical HAdV receptor, CAR was variable. Together, these data indicate an important role for SA engagement in the tropism of many HAdV-D and may facilitate the development of suitable antivirals to control EKC outbreaks.

Published
2023

160. Multidisciplinary Approach to Improving Safety in Transesophageal Echocardiography in Patients With Relative Contraindications

Author

Kelly L, Mishra, Michael T, Baker, Kara K, Siegrist, Alice, Liao, Andrew E, Scanga, Rishi, Naik, Manhal, Izzy, Matthew D, Spann, Erin A, Gillaspie, Holly M, Gonzales, and Lisa A, Mendes

Subjects
Echocardiography, Contraindications, Humans, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, Echocardiography, Transesophageal
Published
2022

161. A Descriptive Analysis of Patient Outcomes and Experiences at a Student-Run Athletic Training Clinic

Author

Camas Curran, Jayme G. Baker, Matthew Smitley, and Russell T. Baker

Subjects
Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, General Medicine
Abstract

Context The prevalence of student-run clinics is rising due to educational benefits and the ability to provide cost-effective care to underserved patients. Current literature on the effect of athletic training student-run clinics on patient outcomes and experiences is limited. Objective To explore patient-reported outcomes (PROs), patient experiences, and patient demographics in an athletic training student-run clinic. Design Mixed-methods study: cross-sectional survey with retrospective analysis of deidentified patient outcomes from November 2017–October 2021. Setting Athletic training student-run clinic. Patients or Other Participants A total of 388 patients from the university (ie, students and staff) and local community with a variety of musculoskeletal injuries. Main Outcome Measure(s) Participants completed a packet to provide their responses to demographic items and PRO scales: Disablement in the Physically Active Scale Short Form-8, Numeric Pain Rating Scale, Patient-Specific Functional Scale, and Global Rating of Change Scale at 3 time points. They also completed an electronic patient experience survey after their final visit to the student-run clinic. Results Most participants reported clinically significant improvements across all PRO scales: an average improvement of 39.1% in pain, 39.3% in function, and 43.1% in quality of life in Conclusions Patients experienced clinically significant improvements in pain, function, disablement, and quality of life when receiving care from athletic training students at a student-run clinic. In addition, they indicated a high level of satisfaction with the care provided and a positive overall experience with an athletic training student-run clinic.

Published
2022

162. Genome-wide association study reveals novel genetic loci

Author

Carolina Roselli, Mengyao Yu, Victor Nauffal, Adrien Georges, Qiong Yang, Katie Love, Lu Chen Weng, Francesca N Delling, Svetlana R Maurya, Maren Schrölkamp, Jacob Tfelt-Hansen, Albert Hagège, Xavier Jeunemaitre, Stéphanie Debette, Philippe Amouyel, Wyliena Guan, Jochen D Muehlschlegel, Simon C Body, Svati Shah, Zainab Samad, Sergiy Kyryachenko, Carol Haynes, Michiel Rienstra, Thierry Le Tourneau, Vincent Probst, Ronan Roussel, Inez J Wijdh-Den Hamer, Joylene E Siland, Kirk U Knowlton, Jean Jacques Schott, Robert A Levine, Emelia J Benjamin, Ramachandran S Vasan, Benjamin D Horne, Joseph B Muhlestein, Giovanni Benfari, Maurice Enriquez-Sarano, Andrea Natale, Sanghamitra Mohanty, Chintan Trivedi, Moore B Shoemaker, Zachary T Yoneda, Quinn S Wells, Michael T Baker, Eric Farber-Eger, Hector I Michelena, Alicia Lundby, Russell A Norris, Susan A Slaugenhaupt, Christian Dina, Steven A Lubitz, Nabila Bouatia-Naji, Patrick T Ellinor, David J Milan, and Cardiovascular Centre (CVC)

Subjects
Adult, Proteomics, Mitral Valve Prolapse, Latent TGF-beta Binding Proteins, Genetic Loci, Risk Factors, Translational Research, Humans, Mitral Valve Insufficiency, Cardiology and Cardiovascular Medicine, Genome-Wide Association Study
Abstract

AIMS: Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of >2% in the general adult population. Despite this high incidence, there is a limited understanding of the molecular mechanism of this disease, and no medical therapy is available for this disease. We aimed to elucidate the genetic basis of MVP in order to better understand this complex disorder.METHODS AND RESULTS: We performed a meta-analysis of six genome-wide association studies that included 4884 cases and 434 649 controls. We identified 14 loci associated with MVP in our primary analysis and 2 additional loci associated with a subset of the samples that additionally underwent mitral valve surgery. Integration of epigenetic, transcriptional, and proteomic data identified candidate MVP genes including LMCD1, SPTBN1, LTBP2, TGFB2, NMB, and ALPK3. We created a polygenic risk score (PRS) for MVP and showed an improved MVP risk prediction beyond age, sex, and clinical risk factors.CONCLUSION: We identified 14 genetic loci that are associated with MVP. Multiple analyses identified candidate genes including two transforming growth factor-β signalling molecules and spectrin β. We present the first PRS for MVP that could eventually aid risk stratification of patients for MVP screening in a clinical setting. These findings advance our understanding of this common valvular heart disease and may reveal novel therapeutic targets for intervention.KEY QUESTION: Expand our understanding of the genetic basis for mitral valve prolapse (MVP). Uncover relevant pathways and target genes for MVP pathophysiology. Leverage genetic data for MVP risk prediction.KEY FINDING: Sixteen genetic loci were significantly associated with MVP, including 13 novel loci. Interesting target genes at these loci included LTBP2, TGFB2, ALKP3, BAG3, RBM20, and SPTBN1. A risk score including clinical factors and a polygenic risk score, performed best at predicting MVP, with an area under the receiver operating characteristics curve of 0.677.TAKE-HOME MESSAGE: Mitral valve prolapse has a polygenic basis: many genetic variants cumulatively influence pre-disposition for disease. Disease risk may be modulated via changes to transforming growth factor-β signalling, the cytoskeleton, as well as cardiomyopathy pathways. Polygenic risk scores could enhance the MVP risk prediction.

Published
2022

164. Friend or Foe? Impacts of Dietary Xylans, Xylooligosaccharides, and Xylanases on Intestinal Health and Growth Performance of Monogastric Animals

Author

Jonathan T. Baker, Marcos E. Duarte, Debora M. Holanda, and Sung Woo Kim

Subjects
intestinal health, growth performance, poultry, prebiotics, swine, xylooligosaccharides, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

This paper discusses the structural difference and role of xylan, procedures involved in the production of xylooligosaccharides (XOS), and their implementation into animal feeds. Xylan is non-starch polysaccharides that share a β-(1-4)-linked xylopyranose backbone as a common feature. Due to the myriad of residues that can be substituted on the polymers within the xylan family, more anti-nutritional factors are associated with certain types of xylan than others. XOS are sugar oligomers extracted from xylan-containing lignocellulosic materials, such as crop residues, wood, and herbaceous biomass, that possess prebiotic effects. XOS can also be produced in the intestine of monogastric animals to some extent when exogenous enzymes, such as xylanase, are added to the feed. Xylanase supplementation is a common practice within both swine and poultry production to reduce intestinal viscosity and improve digestive utilization of nutrients. The efficacy of xylanase supplementation varies widely due a number of factors, one of which being the presence of xylanase inhibitors present in common feedstuffs. The use of prebiotics in animal feeding is gaining popularity as producers look to accelerate growth rate, enhance intestinal health, and improve other production parameters in an attempt to provide a safe and sustainable food product. Available research on the impact of xylan, XOS, as well as xylanase on the growth and health of swine and poultry, is also summarized. The response to xylanase supplementation in swine and poultry feeds is highly variable and whether the benefits are a result of nutrient release from NSP, reduction in digesta viscosity, production of short chain xylooligosaccharides or a combination of these is still in question. XOS supplementation seems to benefit both swine and poultry at various stages of production, as well as varying levels of XOS purity and degree of polymerization; however, further research is needed to elucidate the ideal dosage, purity, and degree of polymerization needed to confer benefits on intestinal health and performance in each respective species.

Published
2021
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165. Erratum: 'A Gravitational-wave Measurement of the Hubble Constant Following the Second Observing Run of Advanced LIGO and Virgo' (2021, ApJ, 909, 218)

Author

B. P. Abbott, R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, S. Anand, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arène, N. Arnaud, S. M. Aronson, K. G. Arun, S. Ascenzi, G. Ashton, S. M. Aston, P. Astone, F. Aubin, P. Aufmuth, K. AultONeal, C. Austin, V. Avendano, A. Avila-Alvarez, S. Babak, P. Bacon, F. Badaracco, M. K. M. Bader, S. Bae, J. Baird, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, A. Bals, S. Banagiri, J. C. Barayoga, C. Barbieri, S. E. Barclay, B. C. Barish, D. Barker, K. Barkett, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, M. Bazzan, B. Bécsy, M. Bejger, I. Belahcene, A. S. Bell, D. Beniwal, M. G. Benjamin, B. K. Berger, G. Bergmann, S. Bernuzzi, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, R. Bhandare, J. Bidler, E. Biggs, I. A. Bilenko, S. A. Bilgili, G. Billingsley, I. A. Birney, O. Birnholtz, S. Biscans, M. Bischi, S. Biscoveanu, A. Bisht, M. Bitossi, M. A. Bizouard, J. K. Blackburn, J. Blackman, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, F. Bobba, N. Bode, M. Boer, Y. Boetzel, G. Bogaert, F. Bondu, R. Bonnand, P. Booker, B. A. Boom, R. Bork, V. Boschi, S. Bose, V. Bossilkov, J. Bosveld, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, M. Branchesi, J. E. Brau, M. Breschi, T. Briant, J. H. Briggs, F. Brighenti, A. Brillet, M. Brinkmann, P. Brockill, A. F. Brooks, J. Brooks, D. D. Brown, S. Brunett, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. A. Callister, E. Calloni, J. B. Camp, W. A. Campbell, M. Canepa, K. C. Cannon, H. Cao, J. Cao, G. Carapella, F. Carbognani, S. Caride, M. F. Carney, G. Carullo, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglià, F. Cavalier, R. Cavalieri, G. Cella, P. Cerdá-Durán, E. Cesarini, O. Chaibi, K. Chakravarti, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. A. Chase, E. Chassande-Mottin, D. Chatterjee, M. Chaturvedi, B. D. Cheeseboro, H. Y. Chen, X. Chen, Y. Chen, H.-P. Cheng, C. K. Cheong, H. Y. Chia, F. Chiadini, A. Chincarini, A. Chiummo, G. Cho, H. S. Cho, M. Cho, N. Christensen, Q. Chu, S. Chua, K. W. Chung, S. Chung, G. Ciani, M. Cieślar, A. A. Ciobanu, R. Ciolfi, F. Cipriano, A. Cirone, F. Clara, J. A. Clark, P. Clearwater, F. Cleva, E. Coccia, P.-F. Cohadon, D. Cohen, M. Colleoni, C. G. Collette, C. Collins, M. Colpi, L. R. Cominsky, M. Constancio Jr., L. Conti, S. J. Cooper, P. Corban, T. R. Corbitt, I. Cordero-Carrión, S. Corezzi, K. R. Corley, N. Cornish, D. Corre, A. Corsi, S. Cortese, C. A. Costa, R. Cotesta, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, P. B. Covas, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, J. D. E. Creighton, T. D. Creighton, J. Cripe, M. Croquette, S. G. Crowder, T. J. Cullen, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, G. Dálya, B. D’Angelo, S. L. Danilishin, S. D’Antonio, K. Danzmann, A. Dasgupta, C. F. Da Silva Costa, L. E. H. Datrier, V. Dattilo, I. Dave, M. Davier, D. Davis, E. J. Daw, D. DeBra, M. Deenadayalan, J. Degallaix, M. De Laurentis, S. Deléglise, W. Del Pozzo, L. M. DeMarchi, N. Demos, T. Dent, R. De Pietri, R. De Rosa, C. De Rossi, R. DeSalvo, O. de Varona, S. Dhurandhar, M. C. Díaz, T. Dietrich, L. Di Fiore, C. DiFronzo, C. Di Giorgio, F. Di Giovanni, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, B. Ding, S. Di Pace, I. Di Palma, F. Di Renzo, A. K. Divakarla, A. Dmitriev, Z. Doctor, F. Donovan, K. L. Dooley, S. Doravari, I. Dorrington, T. P. Downes, M. Drago, J. C. Driggers, Z. Du, J.-G. Ducoin, P. Dupej, O. Durante, S. E. Dwyer, P. J. Easter, G. Eddolls, T. B. Edo, A. Effler, P. Ehrens, J. Eichholz, S. S. Eikenberry, M. Eisenmann, R. A. Eisenstein, L. Errico, R. C. Essick, H. Estelles, D. Estevez, Z. B. Etienne, T. Etzel, M. Evans, T. M. Evans, V. Fafone, S. Fairhurst, X. Fan, S. Farinon, B. Farr, W. M. Farr, E. J. Fauchon-Jones, M. Favata, M. Fays, M. Fazio, C. Fee, J. Feicht, M. M. Fejer, F. Feng, A. Fernandez-Galiana, I. Ferrante, E. C. Ferreira, T. A. Ferreira, F. Fidecaro, I. Fiori, D. Fiorucci, M. Fishbach, R. P. Fisher, J. M. Fishner, R. Fittipaldi, M. Fitz-Axen, V. Fiumara, R. Flaminio, M. Fletcher, E. Floden, E. Flynn, H. Fong, J. A. Font, P. W. F. Forsyth, J.-D. Fournier, Francisco Hernandez Vivanco, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, P. Fritschel, V. V. Frolov, G. Fronzè, P. Fulda, M. Fyffe, H. A. Gabbard, B. U. Gadre, S. M. Gaebel, J. R. Gair, L. Gammaitoni, S. G. Gaonkar, C. García-Quirós, F. Garufi, B. Gateley, S. Gaudio, G. Gaur, V. Gayathri, G. Gemme, E. Genin, A. Gennai, D. George, J. George, L. Gergely, S. Ghonge, Abhirup Ghosh, Archisman Ghosh, S. Ghosh, B. Giacomazzo, J. A. Giaime, K. D. Giardina, D. R. Gibson, K. Gill, L. Glover, J. Gniesmer, P. Godwin, E. Goetz, R. Goetz, B. Goncharov, G. González, J. M. Gonzalez Castro, A. Gopakumar, S. E. Gossan, M. Gosselin, R. Gouaty, B. Grace, A. Grado, M. Granata, A. Grant, S. Gras, P. Grassia, C. Gray, R. Gray, G. Greco, A. C. Green, R. Green, E. M. Gretarsson, A. Grimaldi, S. J. Grimm, P. Groot, H. Grote, S. Grunewald, P. Gruning, G. M. Guidi, H. K. Gulati, Y. Guo, A. Gupta, Anchal Gupta, P. Gupta, E. K. Gustafson, R. Gustafson, L. Haegel, O. Halim, B. R. Hall, E. D. Hall, E. Z. Hamilton, G. Hammond, M. Haney, M. M. Hanke, J. Hanks, C. Hanna, M. D. Hannam, O. A. Hannuksela, T. J. Hansen, J. Hanson, T. Harder, T. Hardwick, K. Haris, J. Harms, G. M. Harry, I. W. Harry, R. K. Hasskew, C. J. Haster, K. Haughian, F. J. Hayes, J. Healy, A. Heidmann, M. C. Heintze, H. Heitmann, F. Hellman, P. Hello, G. Hemming, M. Hendry, I. S. Heng, J. Hennig, M. Heurs, S. Hild, T. Hinderer, S. Hochheim, D. Hofman, A. M. Holgado, N. A. Holland, K. Holt, D. E. Holz, P. Hopkins, C. Horst, J. Hough, E. J. Howell, C. G. Hoy, Y. Huang, M. T. Hübner, E. A. Huerta, D. Huet, B. Hughey, V. Hui, S. Husa, S. H. Huttner, T. Huynh-Dinh, B. Idzkowski, A. Iess, H. Inchauspe, C. Ingram, R. Inta, G. Intini, B. Irwin, H. N. Isa, J.-M. Isac, M. Isi, B. R. Iyer, T. Jacqmin, S. J. Jadhav, K. Jani, N. N. Janthalur, P. Jaranowski, D. Jariwala, A. C. Jenkins, J. Jiang, D. S. Johnson, A. W. Jones, D. I. Jones, J. D. Jones, R. Jones, R. J. G. Jonker, L. Ju, J. Junker, C. V. Kalaghatgi, V. Kalogera, B. Kamai, S. Kandhasamy, G. Kang, J. B. Kanner, S. J. Kapadia, C. Karathanasis, S. Karki, R. Kashyap, M. Kasprzack, S. Katsanevas, E. Katsavounidis, W. Katzman, S. Kaufer, K. Kawabe, N. V. Keerthana, F. Kéfélian, D. Keitel, R. Kennedy, J. S. Key, F. Y. Khalili, I. Khan, S. Khan, E. A. Khazanov, N. Khetan, M. Khursheed, N. Kijbunchoo, Chunglee Kim, J. C. Kim, K. Kim, W. Kim, W. S. Kim, Y.-M. Kim, C. Kimball, P. J. King, M. Kinley-Hanlon, R. Kirchhoff, J. S. Kissel, L. Kleybolte, J. H. Klika, S. Klimenko, T. D. Knowles, P. Koch, S. M. Koehlenbeck, G. Koekoek, S. Koley, V. Kondrashov, A. Kontos, N. Koper, M. Korobko, W. Z. Korth, M. Kovalam, D. B. Kozak, C. Krämer, V. Kringel, N. Krishnendu, A. Królak, N. Krupinski, G. Kuehn, A. Kumar, P. Kumar, Rahul Kumar, Rakesh Kumar, L. Kuo, A. Kutynia, S. Kwang, B. D. Lackey, D. Laghi, K. H. Lai, T. L. Lam, M. Landry, B. B. Lane, R. N. Lang, J. Lange, B. Lantz, R. K. Lanza, A. Lartaux-Vollard, P. D. Lasky, M. Laxen, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, Y. K. Lecoeuche, C. H. Lee, H. K. Lee, H. M. Lee, H. W. Lee, J. Lee, K. Lee, J. Lehmann, A. K. Lenon, N. Leroy, N. Letendre, Y. Levin, A. Li, J. Li, K. J. L. Li, T. G. F. Li, X. Li, F. Lin, F. Linde, S. D. Linker, T. B. Littenberg, J. Liu, X. Liu, M. Llorens-Monteagudo, R. K. L. Lo, L. T. London, A. Longo, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, C. O. Lousto, G. Lovelace, M. E. Lower, H. Lück, D. Lumaca, A. P. Lundgren, R. Lynch, Y. Ma, R. Macas, S. Macfoy, M. MacInnis, D. M. Macleod, A. Macquet, I. Magaña Hernandez, F. Magaña-Sandoval, R. M. Magee, E. Majorana, I. Maksimovic, A. Malik, N. Man, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, M. Mapelli, F. Marchesoni, F. Marion, S. Márka, Z. Márka, C. Markakis, A. S. Markosyan, A. Markowitz, E. Maros, A. Marquina, S. Marsat, F. Martelli, I. W. Martin, R. M. Martin, V. Martinez, D. V. Martynov, H. Masalehdan, K. Mason, E. Massera, A. Masserot, T. J. Massinger, M. Masso-Reid, S. Mastrogiovanni, A. Matas, F. Matichard, L. Matone, N. Mavalvala, J. J. McCann, R. McCarthy, D. E. McClelland, S. McCormick, L. McCuller, S. C. McGuire, C. McIsaac, J. McIver, D. J. McManus, T. McRae, S. T. McWilliams, D. Meacher, G. D. Meadors, M. Mehmet, A. K. Mehta, J. Meidam, E. Mejuto Villa, A. Melatos, G. Mendell, R. A. Mercer, L. Mereni, K. Merfeld, E. L. Merilh, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, F. Messina, R. Metzdorff, P. M. Meyers, F. Meylahn, A. Miani, H. Miao, C. Michel, H. Middleton, L. Milano, A. L. Miller, M. Millhouse, J. C. Mills, M. C. Milovich-Goff, O. Minazzoli, Y. Minenkov, A. Mishkin, C. Mishra, T. Mistry, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, G. Mo, D. Moffa, K. Mogushi, S. R. P. Mohapatra, M. Molina-Ruiz, M. Mondin, M. Montani, C. J. Moore, D. Moraru, F. Morawski, G. Moreno, S. Morisaki, B. Mours, C. M. Mow-Lowry, F. Muciaccia, Arunava Mukherjee, D. Mukherjee, S. Mukherjee, Subroto Mukherjee, N. Mukund, A. Mullavey, J. Munch, E. A. Muñiz, M. Muratore, P. G. Murray, A. Nagar, I. Nardecchia, L. Naticchioni, R. K. Nayak, B. F. Neil, J. Neilson, G. Nelemans, T. J. N. Nelson, M. Nery, A. Neunzert, L. Nevin, K. Y. Ng, S. Ng, C. Nguyen, P. Nguyen, D. Nichols, S. A. Nichols, S. Nissanke, F. Nocera, C. North, L. K. Nuttall, M. Obergaulinger, J. Oberling, B. D. O’Brien, G. Oganesyan, G. H. Ogin, J. J. Oh, S. H. Oh, F. Ohme, H. Ohta, M. A. Okada, M. Oliver, P. Oppermann, Richard J. Oram, B. O’Reilly, R. G. Ormiston, L. F. Ortega, R. O’Shaughnessy, S. Ossokine, D. J. Ottaway, H. Overmier, B. J. Owen, A. E. Pace, G. Pagano, M. A. Page, G. Pagliaroli, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, H. Pan, P. K. Panda, P. T. H. Pang, C. Pankow, F. Pannarale, B. C. Pant, F. Paoletti, A. Paoli, A. Parida, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, M. Patil, B. Patricelli, E. Payne, B. L. Pearlstone, T. C. Pechsiri, A. J. Pedersen, M. Pedraza, R. Pedurand, A. Pele, S. Penn, A. Perego, C. J. Perez, C. Périgois, A. Perreca, J. Petermann, H. P. Pfeiffer, M. Phelps, K. S. Phukon, O. J. Piccinni, M. Pichot, F. Piergiovanni, V. Pierro, G. Pillant, L. Pinard, I. M. Pinto, M. Pirello, M. Pitkin, W. Plastino, R. Poggiani, D. Y. T. Pong, S. Ponrathnam, P. Popolizio, E. K. Porter, J. Powell, A. K. Prajapati, J. Prasad, K. Prasai, R. Prasanna, G. Pratten, T. Prestegard, M. Principe, G. A. Prodi, L. Prokhorov, M. Punturo, P. Puppo, M. Pürrer, H. Qi, V. Quetschke, P. J. Quinonez, F. J. Raab, G. Raaijmakers, H. Radkins, N. Radulesco, P. Raffai, S. Raja, C. Rajan, B. Rajbhandari, M. Rakhmanov, K. E. Ramirez, A. Ramos-Buades, Javed Rana, K. Rao, P. Rapagnani, V. Raymond, M. Razzano, J. Read, T. Regimbau, L. Rei, S. Reid, D. H. Reitze, P. Rettegno, F. Ricci, C. J. Richardson, J. W. Richardson, P. M. Ricker, G. Riemenschneider, K. Riles, M. Rizzo, N. A. Robertson, F. Robinet, A. Rocchi, L. Rolland, J. G. Rollins, V. J. Roma, M. Romanelli, J. Romano, R. Romano, C. L. Romel, J. H. Romie, C. A. Rose, D. Rose, K. Rose, D. Rosińska, S. G. Rosofsky, M. P. Ross, S. Rowan, A. Rüdiger, P. Ruggi, G. Rutins, K. Ryan, S. Sachdev, T. Sadecki, M. Sakellariadou, O. S. Salafia, L. Salconi, M. Saleem, A. Samajdar, L. Sammut, E. J. Sanchez, L. E. Sanchez, N. Sanchis-Gual, J. R. Sanders, K. A. Santiago, E. Santos, N. Sarin, B. Sassolas, B. S. Sathyaprakash, O. Sauter, R. L. Savage, P. Schale, M. Scheel, J. Scheuer, P. Schmidt, R. Schnabel, R. M. S. Schofield, A. Schönbeck, E. Schreiber, B. W. Schulte, B. F. Schutz, J. Scott, S. M. Scott, E. Seidel, D. Sellers, A. S. Sengupta, N. Sennett, D. Sentenac, V. Sequino, A. Sergeev, Y. Setyawati, D. A. Shaddock, T. Shaffer, M. S. Shahriar, M. B. Shaner, A. Sharma, P. Sharma, P. Shawhan, H. Shen, R. Shink, D. H. Shoemaker, D. M. Shoemaker, K. Shukla, S. ShyamSundar, K. Siellez, M. Sieniawska, D. Sigg, L. P. Singer, D. Singh, N. Singh, A. Singhal, A. M. Sintes, S. Sitmukhambetov, V. Skliris, B. J. J. Slagmolen, T. J. Slaven-Blair, J. R. Smith, R. J. E. Smith, S. Somala, E. J. Son, S. Soni, B. Sorazu, F. Sorrentino, T. Souradeep, E. Sowell, A. P. Spencer, M. Spera, A. K. Srivastava, V. Srivastava, K. Staats, C. Stachie, M. Standke, D. A. Steer, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, S. P. Stevenson, D. Stocks, R. Stone, D. J. Stops, K. A. Strain, G. Stratta, S. E. Strigin, A. Strunk, R. Sturani, A. L. Stuver, V. Sudhir, T. Z. Summerscales, L. Sun, S. Sunil, A. Sur, J. Suresh, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, S. C. Tait, C. Talbot, D. B. Tanner, D. Tao, M. Tápai, A. Tapia, J. D. Tasson, R. Taylor, R. Tenorio, L. Terkowski, M. Thomas, P. Thomas, S. R. Thondapu, K. A. Thorne, E. Thrane, Shubhanshu Tiwari, Srishti Tiwari, V. Tiwari, K. Toland, M. Tonelli, Z. Tornasi, A. Torres-Forné, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, M. C. Tringali, A. Tripathee, A. Trovato, L. Trozzo, K. W. Tsang, M. Tse, R. Tso, L. Tsukada, D. Tsuna, T. Tsutsui, D. Tuyenbayev, K. Ueno, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, M. Valentini, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, L. van der Schaaf, J. V. VanHeijningen, A. A. van Veggel, M. Vardaro, V. Varma, S. Vass, M. Vasúth, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, G. Venugopalan, D. Verkindt, F. Vetrano, A. Viceré, A. D. Viets, S. Vinciguerra, D. J. Vine, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, R. Walet, M. Walker, L. Wallace, S. Walsh, H. Wang, J. Z. Wang, S. Wang, W. H. Wang, Y. F. Wang, R. L. Ward, Z. A. Warden, J. Warner, M. Was, J. Watchi, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, F. Wellmann, L. Wen, E. K. Wessel, P. Weßels, J. W. Westhouse, K. Wette, J. T. Whelan, B. F. Whiting, C. Whittle, D. M. Wilken, D. Williams, A. R. Williamson, J. L. Willis, B. Willke, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Woehler, J. K. Wofford, J. L. Wright, D. S. Wu, D. M. Wysocki, S. Xiao, R. Xu, H. Yamamoto, C. C. Yancey, L. Yang, Y. Yang, Z. Yang, M. J. Yap, M. Yazback, D. W. Yeeles, Hang Yu, Haocun Yu, S. H. R. Yuen, A. K. Zadrożny, A. Zadrożny, M. Zanolin, T. Zelenova, J.-P. Zendri, M. Zevin, J. Zhang, L. Zhang, T. Zhang, C. Zhao, G. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, A. B. Zimmerman, M. E. Zucker, J. Zweizig, and The LIGO Scientific Collaboration and the Virgo Collaboration

Subjects
Astrophysics, QB460-466
Published
2021
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170. Violence in the Military

Author

Monty T. Baker, Alyssa R. Ojeda, Hannah Pressley, Jessica Blalock, Riki Ann Martinez, Brian A. Moore, and Vincent B. Van Hasselt

Published
2023

174. Suicide and Self-Harm in the Military

Author

Monty T. Baker, Alyssa R. Ojeda, Hannah Pressley, Jessica Blalock, Riki Ann Martinez, Brian A. Moore, and Vincent B. Van Hasselt

Published
2023

175. The International Pulsar Timing Array: Second Data Release

Author

B B P Perara, M E DeCesar, P B Demorest, M Kerr, L Lentati, D J Nice, S Oslowski, S M Ransom, M J Keith, Z Arzoumanian, M Bailes, P T Baker, C G Bassa, NDR Bhat, A Brazier, M Burgay, S Burke-Spolaor, R N Caballero, D J Champion, S Chatterjee, S Chen, I Cognard, J M Cordes, K Crowter, S Dai, G Desvignes, T Dolch, R D Ferdman, E C Ferrara, E Fonseca, J M Goldstein, E Graikou, L Guillemot, J S Hazboun, G Hobbs, H Hu, K Islo, G H Janssen, R Karuppusam, M Kramer, M T Lam, K J Lee, K Liu, J Luo, A G Lyne, R N Manchester, J W McKee, M A McLaughlin, C M F Mingarelli, A P Parthasarathy, T T Pennucci, D Perrodin, A Possenti, D J Reardon, C J Russell, S A Sanidas, A Sesana, G Shaifullah, R M Shannon, X Siemens, J Simon, R Spiewak, I H Stairs, B W Stappers, J K Swiggum, S R Taylor, G Theureau, C Tiburzi, M Vallisneri, A Vecchio, J B Wang, S B Zhang, L Zhang, W W Zhu, and X J Zhu

Subjects
Astronomy
Abstract

In this paper, we describe the International Pulsar Timing Array second data release, which includes recent pulsar timing data obtained by three regional consortia: the European Pulsar Timing Array, the North American Nanohertz Observatory for Gravitational Waves, and the Parkes Pulsar Timing Array. We analyse and where possible combine high-precision timing data for 65 millisecond pulsars which are regularly observed by these groups. A basic noise analysis, including the processes which are both correlated and uncorrelated in time, provides noise models and timing ephemerides for the pulsars. We find that the timing precisions of pulsars are generally improved compared to the previous data release, mainly due to the addition of new data in the combination. The main purpose of this work is to create the most up-to-date IPTA data release. These data are publicly available for searches for low-frequency gravitational waves and other pulsar science.

Published
2019
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176. Directional limits on persistent gravitational waves using data from Advanced LIGO’s first two observing runs

Author

B. P. Abbott, R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arene, N. Arnaud, S. Ascenzi, G. Ashton, S. M. Aston, P. Astone, F. Aubin, P. Aufmuth, K. AultONeal, C. Austin, V. Avendano, A. Avila-Alvarez, S. Babak, P. Bacon, F. Badaracco, M. K. M. Bader, S. Bae, P. T. Baker, F. Baldaccini, G. Ballardin, S.W. Ballmer, S. Banagiri, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, K. Barkett, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, M. Bazzan, B. Becsy, M. Bejger, I. Belahcene, A. S. Bell, D. Beniwal, B. K. Berger, G. Bergmann, S. Bernuzzi, J. J. Bero, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, R. Bhandare, J. Bidler, I. A. Bilenko, S. A. Bilgili, G. Billingsley, J. Birch, R. Birney, O. Birnholtz, S. Biscans, S. Biscoveanu, A. Bisht, M. Bitossi, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, N. Bode, M. Boer, Y. Boetzel, G. Bogaert, F. Bondu, E. Bonilla, R. Bonnand, P. Booker, B. A. Boom, C. D. Booth, R. Bork, V. Boschi, S. Bose, K. Bossie, V. Bossilkov, J. Bosveld, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, M. Branchesi, J. E. Brau, T. Briant, J. H. Briggs, F. Brighenti, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. D. Brown, S. Brunett, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. A. Callister, E. Calloni, J. B. Camp, W. A. Campbell, M. Canepa, K. C. Cannon, H. Cao, J. Cao, E. Capocasa, F. Carbognani, S. Caride, M. F. Carney, G. Carullo, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavaglia, F. Cavalier, R. Cavalieri, G. Cella, P. Cerdá-Durán, G. Cerretani, E. Cesarini, O. Chaibi, K. Chakravarti, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. A. Chase, E. Chassande-Mottin, D. Chatterjee, M. Chaturvedi, B. D. Cheeseboro, H. Y. Chen, X. Chen, Y. Chen, H.-P. Cheng, C. K. Cheong, H. Y. Chia, A. Chincarini, A. Chiummo, G. Cho, H. S. Cho, M. Cho, N. Christensen, Q. Chu, S. Chua, K.W. Chung, S. Chung, G. Ciani, A. A. Ciobanu, R. Ciolfi, F. Cipriano, A. Cirone, F. Clara, J. A. Clark, P. Clearwater, F. Cleva, C. Cocchieri, E. Coccia, P.-F. Cohadon, D. Cohen, R. Colgan, M. Colleoni, C. G. Collette, C. Collins, L. R. Cominsky, M. Constancio Jr, L. Conti, S. J. Cooper, P. Corban, T. R. Corbitt, I. Cordero-Carrión, K. R. Corley, N. Cornish, A. Corsi, S. Cortese, C. A. Costa, R. Cotesta, M.W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, P. B. Covas, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, J. D. E. Creighton, T. D. Creighton, J. Cripe, M. Croquette, S. G. Crowder, T. J. Cullen, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, G. Dálya, S. L. Danilishin, S. D’Antonio, K. Danzmann, A. Dasgupta, C. F. Da Silva Costa, L. E. H. Datrier, V. Dattilo, I. Dave, M. Davier, D. Davis, E. J. Daw, D. DeBra, M. Deenadayalan, J. Degallaix, M. De Laurentis, S. Del´eglise, W. Del Pozzo, L. M. DeMarchi, N. Demos, T. Dent, R. De Pietri, J. Derby, R. De Rosa, C. De Rossi, R. DeSalvo, O. de Varona, S. Dhurandhar, M. C. Díaz, T. Dietrich, L. Di Fiore, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, B. Ding, S. Di Pace, I. Di Palma, F. Di Renzo, A. Dmitriev, Z. Doctor, F. Donovan, K. L. Dooley, S. Doravari, I. Dorrington, T. P. Downes, M. Drago, J. C. Driggers, Z. Du, J.-G. Ducoin, P. Dupej, I. Dvorkin, S. E. Dwyer, P. J. Easter, T. B. Edo, M. C. Edwards, A. Effler, P. Ehrens, J. Eichholz, S. S. Eikenberry, M. Eisenmann, R. A. Eisenstein, R. C. Essick, H. Estelles, D. Estevez, Z. B. Etienne, T. Etzel, M. Evans, T. M. Evans, V. Fafone, H. Fair, S. Fairhurst, X. Fan, S. Farinon, B. Farr, W. M. Farr, E. J. Fauchon-Jones, M. Favata, M. Fays, M. Fazio, C. Fee, J. Feicht, M. M. Fejer, F. Feng, A. Fernandez-Galiana, I. Ferrante, E. C. Ferreira, T. A. Ferreira, F. Ferrini, F. Fidecaro, I. Fiori, D. Fiorucci, M. Fishbach, R. P. Fisher, J. M. Fishner, M. Fitz-Axen, R. Flaminio, M. Fletcher, E. Flynn, H. Fong, J. A. Font, P.W. F. Forsyth, J.-D. Fournier, S. Frasca, F. Frasconi, Z. Frei, A. Freise, R. Frey, V. Frey, P. Fritschel, V. V. Frolov, P. Fulda, M. Fyffe, H. A. Gabbard, B. U. Gadre, S. M. Gaebel, J. R. Gair, L. Gammaitoni, M. R. Ganija, S. G. Gaonkar, A. Garcia, C. García-Quirós, F. Garufi, B. Gateley, S. Gaudio, G. Gaur, V. Gayathri, G. Gemme, E. Genin, A. Gennai, D. George, J. George, L. Gergely, V. Germain, S. Ghonge, Abhirup Ghosh, Archisman Ghosh, S. Ghosh, B. Giacomazzo, J. A. Giaime, K. D. Giardina, A. Giazotto, K. Gill, G. 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Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Woehler, J. K. Wofford, J. Worden, J. L. Wright, D. S. Wu, D. M. Wysocki, L. Xiao, R. Xu, H. Yamamoto, C. C. Yancey, L. Yang, M. J. Yap, M. Yazback, D.W. Yeeles, Hang Yu, Haocun Yu, S. H. R. Yuen, M. Yvert, A. K. Zadrożny, M. Zanolin, T. Zelenova, J.-P. Zendri, M. Zevin, J. Zhang, L. Zhang, T. Zhang, C. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, M. E. Zucker, and J. Zweizig

Subjects
Space Sciences (General)
Abstract

We perform an unmodeled search for persistent, directional gravitational wave (GW) sources using data from the first and second observing runs of Advanced LIGO. We do not find evidence for any GW signals. We place limits on the broadband GW flux emitted at 25 Hz from point sources with a power law spectrum at F(α;Θ) < (0.05–25) × 10^(−8) erg/sq. cmsHz and the (normalized) energy density spectrum in GWs at 25 Hz from extended sources at Ω(α)(Θ) < (0.19–2.89) × 10^(−8) per sr where α is the spectral index of the energy density spectrum. These represent improvements of 2.5–3× over previous limits. We also consider point sources emitting GWs at a single frequency, targeting the directions of Sco X-1, SN 1987A, and the Galactic center. The best upper limits on the strain amplitude of a potential source in these three directions range from h(0) < (3.6–4.7) × 10^(−25), 1.5× better than previous limits set with the same analysis method. We also report on a marginally significant outlier at 36.06 Hz. This outlier is not consistent with a persistent gravitational-wave source as its significance diminishes when combining all of the available data.

Published
2019
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177. GWTC-1: A Gravitational-Wave Transient Catalog of Compact Binary Mergers Observedby LIGO and Virgo During the First and Second Observing Runs

Author

Jordan B Camp, B. P. Abbott, R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arene, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, S. M. Aston, P. Astone, F. Aubin, P. Aufmuth, K. AultONeal, C. Austin, V. Avendano, A. Avila-Alvarez, S. Babak, P. Bacon, F. Badaracco, M. K. M. Bader, S. Bae, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, S. Banagiri, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, K. Barkett, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, M. Bazzan, B. Becsy53M. Bejger, I. Belahcene, A. S. Bell, D. Beniwal, B. K. Berger, G. Bergmann, S. 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Westhouse, K. Wette, J. T. Whelan, L. V. White, B. F. Whiting, C. Whittle, D. M. Wilken, D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Woehler, J. K. Wofford, J. Worden, J. L. Wright, D. S. Wu, D. M. Wysocki, L. Xiao, H. Yamamoto, C. C. Yancey, L. Yang, M. J. Yap, M. Yazback, D. W. Yeeles, Hang Yu, Haocun Yu, S. H. R. Yuen, M. Yvert, A. K. Zadrożny, M. Zanolin, F. Zappa, T. Zelenova, J.-P. Zendri, M. Zevin, J. Zhang, L. Zhang, T. Zhang, C. Zhao, M. Zhou, Z. Zhou, X. J. Zhu, A. B. Zimmerman, Y. Zlochower, M. E. Zucker, and J. Zweizig

Subjects
Astrophysics
Abstract

We present the results from three gravitational-wave searches for coalescing compact binaries with component masses above1M during the first and second observing runs of the advanced gravitational-wave detector network. During the first observing run (O1), from September 12, 2015 to January 19, 2016, gravitational waves from three binary black hole mergers were detected. The second observing run (O2), which ran from November 30, 2016 to August 25, 2017, saw the first detection of gravitational waves from a binary neutron star in spiral, in addition to the observation of gravitational waves from a total of seven binary black hole mergers, four of which we report here for the first time: GW170729, GW170809, GW170818, and GW170823. For all significant gravitational-wave events, we provide estimates of the source properties. The detected binary black holes have total masses between18.6þ3.2−0.7M and 84.4þ15.8−11.1M and range in distance between 320þ120−110 and 2840þ1400−1360Mpc. No neutron star–black hole mergers were detected. In addition to highly significant gravitational-wave events, we also provide a list of marginal event candidates with an estimated false-alarm rate less than 1 per 30 days. From these results over the first two observing runs, which include approximately one gravitational-wave detection per 15 days of data searched, we infer merger rates at the 90% confidence intervals of 110−3840Gpc−3y−1 for binary neutron stars and 9.7−101Gpc−3y−1 for binary black holes assuming fixed population distributions and determine a neutron star–black hole merger rate 90% upper limit of 610Gpc−3y−1.

Published
2019
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178. Low-Latency Gravitational-Wave Alerts for Multimessenger Astronomy During the Second Advanced LIGO and Virgo Observing Run

Author

Leo Pound Singer, Jordan B Camp, B. P. Abbott, R. Abbott, T. D. Abbott, S. Abraham, F. Acernese, K. Ackley, C. Adams, R. X. Adhikari, V. B. Adya, C. Affeldt, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arène, N. Arnaud, S. Ascenzi, G. Ashton, S. M. Aston, P. Astone, F. Aubin, P. Aufmuth, K. AultONeal, C. Austin, V. Avendano, A. Avila-Alvarez, S. Babak, P. Bacon, F. Badaracco, M. K. M. Bader, S. Bae, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, S. Banagiri, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, K. Barkett, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, M. Bawaj, J. C. Bayley, M. Bazzan, B. Bécsy, M. Bejger, I. Belahcene, A. S. Bell, D. Beniwal, B. K. Berger, G. Bergmann, S. Bernuzzi, J. J. Bero, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, R. Bhandare, J. Bidler, I. A. Bilenko, S. A. Bilgili, G. Billingsley, J. Birch, R. Birney, O. Birnholtz, S. Biscans, S. Biscoveanu, A. Bisht, M. Bitossi, M. A. Bizouard, J. K. Blackburn, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, N. Bode, M. Boer, Y. Boetzel, G. Bogaert, F. Bondu, E. Bonilla, R. Bonnand, P. Booker, B. A. Boom, C. D. Booth, R. Bork, V. Boschi, S. Bose, K. Bossie, V. Bossilkov, J. Bosveld, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, M. Branchesi, J. E. Brau, T. Briant, J. H. Briggs, F. Brighenti, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. D. Brown, S. Brunett, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. A. Callister, E. Calloni, J. B. Camp, W. A. Campbell, M. Canepa, K. C. Cannon, H. Cao, J. Cao, E. Capocasa, F. 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Kowalska, D. B. Kozak, V. Kringel, N. Krishnendu, A. Królak, G. Kuehn, A. Kumar, P. Kumar, R. Kumar, S. Kumar, L. Kuo, A. Kutynia, S. Kwang, B. D. Lackey, K.H.Lai, T.L.Lam, M. Landry, B. B. Lane, R. N. Lang, J. Lange, B. Lantz, R. K. Lanza, A. Lartaux-Vollard, P. D. Lasky, M. Laxen, A. Lazzarini, C. Lazzaro, P. Leaci, S. Leavey, Y. K. Lecoeuche, C. H. Lee, H. K. Lee, H. M. Lee, H. W. Lee, J. Lee, K. Lee, J. Lehmann, A. Lenon, N. Leroy, N. Letendre, Y. Levin, J. Li, K. J. L. Li, T. G. F. Li, X. Li, F. Lin, F. Linde, S. D. Linker, T. B. Littenberg, J. Liu, X. Liu, R. K. L. Lo1, N. A. Lockerbie, L. T. London, A. Longo, M. Lorenzini, V. Loriette, M. Lormand, G. Losurdo, J. D. Lough, C. O. Lousto, G. Lovelace, M. E. Lower, H. Lück, D. Lumaca, A. P. Lundgren, R. Lynch, Y. Ma, R. Macas, S. Macfoy, M. MacInnis, D. M. Macleod, A. Macquet, F. Magaña-Sandoval, L. Magaña Zertuche, R. M. Magee, E. Majorana, I. Maksimovic, A. Malik, N. Man, V. Mandic, V. Mangano, G. L. Mansell, M. Manske, M. Mantovani, F. Marchesoni, F. Marion, S. Márka, Z. Márka, C. Markakis, A. S. Markosyan, A. Markowitz, E. Maros, A. Marquina, S. Marsat, F. Martelli, I. W. Martin, R. M. Martin, D. V. Martynov, K. Mason, E. Massera, A. Masserot, T. J. Massinger, M. Masso-Reid, S. Mastrogiovanni, A. Matas, F. Matichard, L. Matone, N. Mavalvala, N. Mazumder, J. J. McCann, R. McCarthy, D. E. McClelland, S. McCormick, L. McCuller, S. C. McGuire, J. McIver, D. J. McManus, T. McRae, S. T. McWilliams, D. Meacher, G. D. Meadors, M. Mehmet, A. K. Mehta, J. Meidam, A. Melatos, G. Mendell, R. A. Mercer, L. Mereni, E. L. Merilh, M. Merzougui, S. Meshkov, C. Messenger, C. Messick, R. Metzdorff, P. M. Meyers, H. Miao, C. Michel, H. Middleton, E. E. Mikhailov, L. Milano, A. L. Miller, A. Miller, M. Millhouse, J. C. Mills, M. C. Milovich-Goff, O. Minazzoli, Y. Minenkov, A. Mishkin, C. Mishra, T. Mistry, S. Mitra, V. P. Mitrofanov, G. Mitselmakher, R. Mittleman, G.Mo, D. Moffa, K. Mogushi, S. R. P. Mohapatra, M. Montani, C. J. Moore, D. Moraru, G. Moreno, S. Morisaki, B. Mours, C. M. Mow-Lowry, Arunava Mukherjee, D. Mukherjee, S. Mukherjee, N. Mukund, A. Mullavey, J. Munch, E. A. Muñiz, M. Muratore, P. G. Murray, A. Nagar, I. Nardecchia, L. Naticchioni, R. K. Nayak, J. Neilson, G. Nelemans, T. J. N. Nelson, M. Nery, A. Neunzert, K. Y. Ng, S. Ng, P. Nguyen, D. Nichols, S. Nissanke, A. Nitz, F. Nocera, C. North, L. K. Nuttall, M. Obergaulinger, J. Oberling, B. D. O’Brien, G. D. O’Dea, G. H. Ogin, J. J. Oh, S. H. Oh, F. Ohme, H. Ohta, M. A. Okada, M. Oliver, P. Oppermann, Richard J. Oram, B. O’Reilly, R. G. Ormiston, L. F. Ortega, R. O’Shaughnessy, S. Ossokine, D. J. Ottaway, H. Overmier, B. J. Owen, A. E. Pace, G. Pagano, M. A. Page, A. Pai, S. A. Pai, J. R. Palamos, O. Palashov, C. Palomba, A. Pal-Singh, Huang-Wei Pan, B. Pang, P. T. H. Pang, C. Pankow, F. Pannarale, B. C. Pant, F. Paoletti, A. Paoli, A. Parida, W. Parker, D. Pascucci, A. Pasqualetti, R. Passaquieti, D. Passuello, M. Patil, B. 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J. E. Smith, S. Somala, E. J. Son, B. Sorazu, F. Sorrentino, T. Souradeep, E. Sowell, A. P. Spencer, A. K. Srivastava, V. Srivastava, K. Staats, C. Stachie, M. Standke, D. A. Steer, M. Steinke, J. Steinlechner, S. Steinlechner, D. Steinmeyer, S. P. Stevenson, D. Stocks, R. Stone, D. J. Stops, K. A. Strain, G. Stratta, S. E. Strigin, A. Strunk, R. Sturani, A. L. Stuver, V. Sudhir, T. Z. Summerscales, L. Sun, S. Sunil, J. Suresh, P. J. Sutton, B. L. Swinkels, M. J. Szczepańczyk, M. Tacca, S. C. Tait, C. Talbot, D. Talukder, D. B. Tanner, M. Tápai, A. Taracchini, J. D. Tasson, R. Taylor, F. Thies, M. Thomas, P. Thomas, S. R. Thondapu, K. A. Thorne, E. Thrane, Shubhanshu Tiwari, Srishti Tiwari, V. Tiwari, K. Toland, M. Tonelli, Z. Tornasi, A. Torres-Forné, C. I. Torrie, D. Töyrä, F. Travasso, G. Traylor, M. C. Tringali, A. Trovato, L. Trozzo, R. Trudeau, K. W. Tsang, M. Tse, R. Tso, L. Tsukada, D. Tsuna, D. Tuyenbayev, K. Ueno, D. Ugolini, C. S. Unnikrishnan, A. L. Urban, S. A. Usman, H. Vahlbruch, G. Vajente, G. Valdes, N. van Bakel, M. van Beuzekom, J. F. J. van den Brand, C. Van Den Broeck, D. C. Vander-Hyde, J. V. van Heijningen, L. van der Schaaf, A. A. van Veggel, M. Vardaro, V. Varma, S. Vass, M. Vasúth, A. Vecchio, G. Vedovato, J. Veitch, P. J. Veitch, K. Venkateswara, G. Venugopalan, D. Verkindt, F. Vetrano, A. Viceré, A. D. Viets, D. J. Vine, J.-Y. Vinet, S. Vitale, T. Vo, H. Vocca, C. Vorvick, S. P. Vyatchanin, A. R. Wade, L. E. Wade, M. Wade, R. Walet, M. Walker, L. Wallace, S. Walsh, G. Wang, H. Wang, J. Z. Wang, W. H. Wang, Y. F. Wang, R. L. Ward, Z. A. Warden, J. Warner, M. Was, J. Watchi, B. Weaver, L.-W. Wei, M. Weinert, A. J. Weinstein, R. Weiss, F. Wellmann, L. Wen, E. K. Wessel, P. Weßels, J. W. Westhouse, K. Wette, J. T. Whelan, B. F. Whiting, C. Whittle, D. M. Wilken, D. Williams, A. R. Williamson, J. L. Willis, B. Willke, M. H. Wimmer, W. Winkler, C. C. Wipf, H. Wittel, G. Woan, J. Woehler, J. K. Wofford, J. Worden, J. L. Wright, D. S. Wu, D. M. Wysocki, L. Xiao, H. Yamamoto, C. C. Yancey, L. Yang, M. J. Yap, M. Yazback, D. W. Yeeles, Hang Yu, Haocun Yu, S. H. R. Yuen, M. Yvert, A. K. Zadrożny, M. Zanolin, T. Zelenova, J.-P. Zendri, M. Zevin, J. Zhang, L. Zhang, T. Zhang, C. Zhao, M. Zhou, Z. Zhou, A. B. Zimmerman, X. J. Zhu, M. E. Zucker, and J. Zweizig

Subjects
Astronomy
Abstract

Advanced LIGO’s second observing run (O2), conducted from 2016 November 30 to 2017 August 25, combined with Advanced Virgo’s first observations in 2017 August, witnessed the birth of gravitational-wave multimessenger astronomy. The first ever gravitational-wave detection from the coalescence of two neutron stars, GW170817, and its gamma-ray counterpart, GRB 170817A, led to an electromagnetic follow-up of the event at an unprecedented scale. Several teams from across the world searched for EM/neutrino counterparts to GW170817, paving the way for the discovery of optical, X-ray, and radio counterparts. In this article, we describe the online identification of gravitational-wave transients and the distribution of gravitational-wave alerts by the LIGO and Virgo collaborations during O2. We also describe the gravitational-wave observables that were sent in the alerts to enable searches for their counterparts. Finally, we give an overview of the online candidate alerts shared with observing partners during O2. Alerts were issued for 14 candidates, 6 of which have been confirmed as gravitational-wave events associated with the merger of black holes or neutron stars. Of the 14 alerts, 8 were issued less than an hour after data acquisition.

Published
2019
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179. High-precision x-ray timing of three millisecond pulsars with NICER: Stability estimates and comparison with radio

Author

J S Deneva, P. S. Ray, A Lommen, S M Ransom, S Bogdanov, M. Kerr, K. S. Wood, Z Arzoumanian, K. Black, J. Doty, K C Gendreau, S. Guillot, A. Harding, N. Lewandowska, C Malacaria, C B Markwardt, S. Price, L Winternitz, M. T. Wolff, L. Guillemot, I. Cognard, P. T. Baker, H. Blumer, P R Brook, H T Cromartie, P B Demorest, M E DeCesar, T. Dolch, J. A. Ellis, R D Ferdman, E C Ferrara, E Fonseca, N Garver-Daniels, P A Gentile, M. L. Jones, M. T. Lam, D R Lorimer, R. S. Lynch, M. A. McLaughlin, C. Ng, D J Nice, T T Pennucci, R Spiewak, I H Stairs, K Stovall, J K Swiggum, S. J. Vigeland, and W. W. Zhu

Subjects
Astrophysics
Abstract

The Neutron Star Interior Composition Explorer (NICER) is an X-ray astrophysics payload on the International Space Station. It enables unprecedented high-precision timing of millisecond pulsars (MSPs) without the pulse broadening and delays due to dispersion and scattering within the interstellar medium that plague radio timing. We present initial timing results from a year of data on the MSPs PSR B1937+21 and PSR J0218+4232, and nine months of data on PSR B1821−24. NICER time-of-arrival uncertainties for the three pulsars are consistent with theoretical lower bounds and simulations based on their pulse shape templates and average source and background photon count rates. To estimate timing stability, we use the σz measure, which is based on the average of the cubic coefficients of polynomial fits to subsets of timing residuals. So far we are achieving timing stabilities σz≈3×10−14 for PSR B1937+21 and on the order of 10−12 for PSRs B1821−24 and J0218+4232. Within the span of our NICER data we do not yet see the characteristic break point in the slope of σz; detection of such a break would indicate that further improvement in the cumulative root-mean-square timing residual is limited by timing noise. We see this break point in our comparison radio data sets for PSR B1821−24 and PSR B1937+21 on timescales of >2 yr.

Published
2019
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180. Constraining the p -Mode– g -Mode Tidal Instability with GW170817

Author

B. P. Abbott, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, B. Agarwal, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, A. Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Arène, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, M. Ast, S. M. Aston, P. Astone, D. V. Atallah, F. Aubin, P. Aufmuth, C. Aulbert, K. AultONeal, C. Austin, A. Avila-Alvarez, S. Babak, P. Bacon, F. Badaracco, M. K. M. Bader, S. Bae, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, S. Banagiri, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, K. Barkett, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, M. Bawaj, J. C. Bayley, M. Bazzan, B. Bécsy, C. Beer, M. Bejger, I. Belahcene, A. S. Bell, D. Beniwal, M. Bensch, B. K. Berger, G. Bergmann, S. Bernuzzi, J. J. Bero, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, R. Bhandare, I. A. Bilenko, S. A. Bilgili, G. Billingsley, C. R. Billman, J. Birch, R. Birney, O. Birnholtz, S. Biscans, S. Biscoveanu, A. Bisht, M. Bitossi, M. A. Bizouard, J. K. Blackburn, J. Blackman, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, O. Bock, N. Bode, M. Boer, Y. Boetzel, G. Bogaert, A. Bohe, F. Bondu, E. Bonilla, R. Bonnand, P. Booker, B. A. Boom, C. D. Booth, R. Bork, V. Boschi, S. Bose, K. Bossie, V. Bossilkov, J. Bosveld, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, M. Branchesi, J. E. Brau, T. Briant, F. Brighenti, A. Brillet, M. Brinkmann, V. Brisson, P. Brockill, A. F. Brooks, D. D. Brown, S. Brunett, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. A. Callister, E. 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2019
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181. Properties of the Binary Neutron Star Merger GW170817

Author

Jordan B Camp, Peter Sven Shawhan, B. P. Abbott, R. Abbott, T. D. Abbott, F. Acernese, K. Ackley, C. Adams, T. Adams, P. Addesso, R. X. Adhikari, V. B. Adya, C. Affeldt, B. Agarwal, M. Agathos, K. Agatsuma, N. Aggarwal, O. D. Aguiar, L. Aiello, A. Ain, P. Ajith, B. Allen, G. Allen, A. Allocca, M. A. Aloy, P. A. Altin, A. Amato, A.Ananyeva, S. B. Anderson, W. G. Anderson, S. V. Angelova, S. Antier, S. Appert, K. Arai, M. C. Araya, J. S. Areeda, M. Ar`ene, N. Arnaud, K. G. Arun, S. Ascenzi, G. Ashton, M. Ast, S. M. Aston, P. Astone, D. V. Atallah, F. Aubin, P. Aufmuth, C. Aulbert, K. AultONeal, C. Austin, A. Avila-Alvarez, S. Babak, P. Bacon, F. Badaracco, M. K. M. Bader, S. Bae, P. T. Baker, F. Baldaccini, G. Ballardin, S. W. Ballmer, S. Banagiri, J. C. Barayoga, S. E. Barclay, B. C. Barish, D. Barker, K. Barkett, S. Barnum, F. Barone, B. Barr, L. Barsotti, M. Barsuglia, D. Barta, J. Bartlett, I. Bartos, R. Bassiri, A. Basti, J. C. Batch, M. Bawaj, J. C. Bayley, M. Bazzan, B. B ́ecsy, C. Beer, M. Bejger, I. Belahcene, A. S. Bell, D. Beniwal, M. Bensch, B. K. Berger, G. Bergmann, S. Bernuzzi, J. J. Bero, C. P. L. Berry, D. Bersanetti, A. Bertolini, J. Betzwieser, R. Bhandare, I. A. Bilenko, S. A. Bilgili, G. Billingsley, C. R. Billman, J. Birch, R. Birney, O. Birnholtz, S. Biscans, S. Biscoveanu, A. Bisht, M. Bitossi, M. A. Bizouard, J. K. Blackburn, J. Blackman, C. D. Blair, D. G. Blair, R. M. Blair, S. Bloemen, O. Bock, N. Bode, M. Boer, Y. Boetzel, G. Bogaert, A. Bohe, F. Bondu, E. Bonilla, R. Bonnand, P. Booker, B. A. Boom, C. D. Booth, R. Bork, V. Boschi, S. Bose, K. Bossie, V. Bossilkov, J. Bosveld, Y. Bouffanais, A. Bozzi, C. Bradaschia, P. R. Brady, A. Bramley, M. Branchesi, J. E. Brau, T. Briant, F. Brighenti, A. Brillet, M. Brinkmann, P. Brockill, A. F. Brooks, D. D. Brown, S. Brunett, C. C. Buchanan, A. Buikema, T. Bulik, H. J. Bulten, A. Buonanno, D. Buskulic, C. Buy, R. L. Byer, M. Cabero, L. Cadonati, G. Cagnoli, C. Cahillane, J. Calderón Bustillo, T. A. Callister, E. Calloni, J. B. Camp, P. Canizares, K. C. Cannon, H. Cao, J. Cao, C. D. Capano, E. Capocasa, F. Carbognani, S. Caride, M. F. Carney, G. Carullo, J. Casanueva Diaz, C. Casentini, S. Caudill, M. Cavagli`a, F. Cavalier, R. Cavalieri, G. Cella, C. B. Cepeda, P. Cerdá-Durán, G. Cerretani, E. Cesarini, O. Chaibi, S. J. Chamberlin, M. Chan, S. Chao, P. Charlton, E. Chase, E. Chassande-Mottin, D. Chatterjee, K. Chatziioannou, B. D. Cheeseboro, H. Y. Chen, X. Chen, Y. Chen, H.-P. Cheng, H. Y. Chia, A. Chincarini, A. Chiummo, T. Chmiel, H. S. Cho, M. Cho, J. H. Chow, N. Christensen, Q. Chu, A. J. K. Chua, S. Chua, K. W. Chung, S. Chung, G. Ciani, A. A. Ciobanu, R. Ciolfi, F. Cipriano, C. E. Cirelli, A. Cirone, F. Clara, J. A. Clark, P. Clearwater, F. Cleva, C. Cocchieri, E. Coccia, P.-F. Cohadon, D. Cohen, A. Colla, C. G. Collette, C. Collins, L. R. Cominsky, M. Constancio Jr, L. Conti, S. J. Cooper, P. Corban, T. R. Corbitt, I. Cordero-Carrión, K. R. Corley, N. Cornish, A. Corsi, S. Cortese, C. A. Costa, R. Cotesta, M. W. Coughlin, S. B. Coughlin, J.-P. Coulon, S. T. Countryman, P. Couvares, P. B. Covas, E. E. Cowan, D. M. Coward, M. J. Cowart, D. C. Coyne, R. Coyne, J. D. E. Creighton, T. D. Creighton, J. Cripe, S. G. Crowder, T. J. Cullen, A. Cumming, L. Cunningham, E. Cuoco, T. Dal Canton, G. Dálya, S. L. Danilishin, S. D’Antonio, K. Danzmann, A. Dasgupta, C. F. Da Silva Costa, V. Dattilo, I. Dave, M. Davier, D. Davis, E. J. Daw, B. Day, D. DeBra, M. Deenadayalan, J. Degalla, M. De Laurentis, S. Del ́eglise, W. Del Pozzo, N. Demos, T. Denker, T. Dent, R. De Pietri, J. Derby, V. Dergachev, R. De Rosa, C. De Rossi, R. DeSalvo, O. de Varona, S. Dhurandhar, M. C. Díaz, T. Dietrich, L. Di Fiore, M. Di Giovanni, T. Di Girolamo, A. Di Lieto, B. Ding, S. Di Pace, I. Di Palma, F. Di Renzo, A. Dmitriev, Z. Doctor, V. Dolique, F. Donovan, K. L. Dooley, S. Doravari, I. Dorrington, M. Dovale Álvarez, James P Downey, M. Drago, C. Dreissigacker, J. C. Driggers, Dusanka Zupanski, R. Dudi, P. Dupej, Eric J Dwyer, P. J. Easter, T. B. Edo, M. C. Edwards, Anamaria Effler, H.-B. Eggenstein, P. Ehrens, J. Eichholz, S. S. Eikenberry, M. Eisenmann, R. A. Eisenstein, R. C. Essick, H. Estelles, D. Estevez, Z. B. Etienne, T. Etzel, and M. Evans

Subjects
Astrophysics
Published
2019
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182. Nutrient and suspended-sediment concentrations in the Maumee River and tributaries during 2019 rain-induced fallow conditions

Author

Lisa M. Hartley, Nicholas J. Reithel, Chad A. Toussant, Jeffrey W. Frey, Stephanie P. Kula, Nancy T. Baker, Katie M. Collier, Carrie A. Huitger, Hunter F. Crates, Kimberly H. Shaffer, Matthew J. Hardebeck, Donna L. Runkle, Dennis P. Finnegan, Ralph J. Haefner, Edward G. Dobrowolski, Tanja N. Williamson, and Thomas L. Weaver

Subjects
geography, geography.geographical_feature_category, Ecology, Phosphorus, chemistry.chemical_element, Sediment, STREAMS, Aquatic Science, chemistry.chemical_compound, Nutrient, Animal science, Nitrate, chemistry, Streamflow, Tributary, Environmental science, Precipitation, Ecology, Evolution, Behavior and Systematics
Abstract

Above average precipitation from October 2018 through July 2019 in the Maumee River (R.) Basin resulted in 29% of cropland left fallow, providing a glimpse of potential effects from decreased nutrient application. Ongoing monitoring at 15 water-quality sites on the Maumee R. upstream from Defiance enabled comparison with 2017, which was hydrologically similar to 2019 in precipitation and streamflow. In 2019, nitrate (as nitrogen; NO3-N) for March-July was significantly less than previous years (2015–2018), but the response for phosphorus (P) was more complicated. Relative to 2017, total P (TP) was lower at 7 of 15 sites, but higher at 7, reflecting higher suspended sediment (SS). Dissolved P (DP) was generally lower, but less different than NO3; DP was higher at 3 sites. DP-P:NO3-N was generally higher in 2019, DP-P:TP was lower, and there was less TP relative to SS. Overall, less P was in the system in 2019. However smaller streams showed a large range of difference between 2019 and 2017 for all constituents, indicating variability in land management and physiography. In contrast, all constituents were lower in 2019 in larger (>5000 km2) streams, including the Maumee R. near Defiance, where the difference in NO3 (−37%) exceeded that for TP (−16%), DP (−10%), and SS (−20%). Differences in these relations among N, P, and SS indicate that P was available from legacy sources that are more difficult to distinguish during typical agricultural production years and that some material from 2019 was stored in the system upstream from the largest sites.

Published
2021

183. dcSBM: A federated constrained source-based morphometry approach for multivariate brain structure mapping

Author

Debbrata K. Saha, Rogers F. Silva, Bradley T. Baker, Rekha Saha, and Vince D. Calhoun

Abstract

The examination of multivariate brain morphometry patterns has gained attention in recent years, especially for their powerful exploratory capabilities in the study of differences between patients and controls. Among many existing methods and tools for analysis of brain anatomy based on structural magnetic resonance imaging (sMRI) data, data-driven source based morphometry (SBM) focuses on the exploratory detection of such patterns. Constrained source-based morphometry (constrained SBM) is a widely used semi-blind extension of SBM that enables extracting maximally independent reference-alike sources using the constrained independent component analysis (ICA) approach. In order to operate, constrained SBM needs the data to be locally accessible. However, there exist many reasons (e.g., the concerns of revealing identifiable rare disease information, or violating strict IRB policies) that may preclude access to data from different sites. In this scenario, constrained SBM fails to leverage the benefits of decentralized data. To mitigate this problem, we present a novel approach: decentralized constrained source-based morphometry (dcSBM). In dcSBM, the original data never leaves the local site. Each site operates constrained ICA on their private local data while using a common distributed computation platform. Then, an aggregator/master node aggregates the results estimated from each local site and applies statistical analysis to find out the significant sources. In our approach, we first use UK Biobank sMRI data to investigate the reliability of our dcSBM algorithm. Finally, we utilize two additional multi-site patient datasets to validate our model by comparing the resulting group difference estimates from both centralized and decentralized constrained SBM.

Published
2022

184. Genetic diversity and fungicide sensitivity of Cytospora plurivora on peach

Author

Stephen T. Baker, Martha H. Froelich, Harriet Boatwright, Hehe Wang, Guido Schnabel, and Julia Kerrigan

Subjects
Plant Science, Agronomy and Crop Science
Abstract

Cytospora plurivora D.P. Lawr., L.A. Holland & Trouillas has been associated with recent premature peach tree decline in South Carolina, but very little is known about the pathogen or chemical control options. Ninety-three C. plurivora isolates were collected in 2016 and 2017 from one-year-old peach wood and symptomatic scaffold limbs, respectively, from orchards in six towns in South Carolina. Six unique genotypes were identified based on substantial ITS1-5.8S-ITS2 sequence variability and classified G1 to G6. Three of the genotypes (G2, G3, and G6) were isolated in high frequency in multiple locations of both years. In addition to the genotypic variation, multiple phenotypes were observed between and within genotype groups. Species identity was determined by the use of additional gene loci: ACT, TUB, and EF, and isolates were found to belong to C. plurivora for all genotype groups. All tested genotypes were sensitive to thiophanate-methyl (FRAC 1) but exhibited slightly lower sensitivity to propiconazole and difenoconazole (both FRAC 3). Boscalid, fluopyram (both FRAC7s), azoxystrobin, and pyraclostrobin (both FRAC 11s) were ineffective in vitro at inhibiting mycelial growth of C. plurivora genotypes. Field inoculation of peach and nectarine trees revealed that all genotypes developed twig cankers with differences in aggressiveness. G1 was most aggressive and G6 was least aggressive. This study provides a link between the C. plurivora genetic variability and aggressiveness and provides fungicide sensitivity information that could be used to improve disease management practices.

Published
2022

185. Reliable and generalizable brain-based predictions of cognitive functioning across common psychiatric illness

Author

Sidhant Chopra, Elvisha Dhamala, Connor Lawhead, Jocelyn A. Ricard, Edwina R. Orchard, Lijun An, Pansheng Chen, Naren Wulan, Poornima Kumar, Arielle Rubenstein, Julia Moses, Lia Chen, Priscila Levi, Alexander Holmes, Kevin Aquino, Alex Fornito, Ilan Harpaz-Rotem, Laura T. Germine, Justin T. Baker, BT Thomas Yeo, and Avram J. Holmes

Abstract

A primary aim of precision psychiatry is the establishment of predictive models linking individual differences in brain functioning with clinical symptoms. In particular, cognitive impairments are transdiagnostic, treatment resistant, and contribute to poor clinical outcomes. Recent work suggests thousands of participants may be necessary for the accurate and reliable prediction of cognition, calling into question the utility of most patient collection efforts. Here, using a transfer-learning framework, we train a model on functional imaging data from the UK Biobank (n=36,848) to predict cognitive functioning in three transdiagnostic patient samples (n=101-224). The model generalizes across datasets, and brain features driving predictions are consistent between populations, with decreased functional connectivity within transmodal cortex and increased connectivity between unimodal and transmodal regions reflecting a transdiagnostic predictor of cognition. This work establishes that predictive models derived in large population-level datasets can be exploited to boost the prediction of cognitive function across clinical collection efforts.

Published
2022

187. A Recent Volcanic Eruption Discovered on the Central Mariana Back-Arc Spreading Center

Author

William W. Chadwick, Susan G. Merle, Edward T. Baker, Sharon L. Walker, Joseph A. Resing, David A. Butterfield, Melissa O. Anderson, Tamara Baumberger, and Andra M. Bobbitt

Subjects
submarine eruption, mariana back-arc spreading center, mariana trough, high-resolution mapping, submarine lava flow morphology, Science
Abstract

Submarine volcanic eruptions are difficult to detect because they are hidden from view at the bottom of the ocean and far from land-based sensors. However, most of Earth’s volcanic activity is in the oceans along tectonic plate boundaries, and modern tools of oceanography now allow us to find and study recent eruptions in the deep sea. The first known historical eruption on the Mariana back-arc spreading center was discovered in December 2015 during exploration of the southern back-arc for new hydrothermal vent sites. A water-column survey along the axis of the back-arc showed hydrothermal plumes over the site characterized by low particle concentrations and relatively high reduced chemical anomalies. A dive with the autonomous underwater vehicle Sentry collected high-resolution (1 m) multibeam sonar bathymetry over the site, followed by a near-bottom photographic survey of a smaller area. The photo survey revealed the presence of a pristine, dark, glassy lava flow on the seafloor with no sediment cover. Venting of milky hydrothermal fluid indicated that the lava flow was still warm and therefore very young. A comparison of multibeam sonar bathymetry collected by R/V Falkor in December 2015, to the most recent previous survey of the area by R/V Melville in February 2013, revealed large depth changes in the same area, effectively bracketing the timing of the eruption within a window of less than 3 years. The bathymetric comparison shows the eruption produced a string of lava flows with maximum thicknesses of 40–138 m along a distance of 7.3 km (from latitude 15°22.3′ to 15°26.3′N) between depths of 4050–4450 m bsl (meters below sea level), making this the deepest known historical submarine volcanic eruption on Earth. The cross-axis width of the lava flows is 200–800 m. The Sentry bathymetry shows that the new lava flows are constructed of steep-sided hummocky pillow mounds and are surrounded by older flows with similar morphology. In April and December 2016, two dives were made on the new lava flows by remotely operated vehicles Deep Discoverer and SuBastian. The pillow lavas have many small glassy buds on the steep flanks of the mounds, locally thick accumulations of hydrothermal sediment near the tops of mounds, and small cones of radiating pillows at their summits. The 2015–2016 observations show a rapidly declining hydrothermal system on the lava flows, suggesting that the eruption had occurred only months before its discovery in December 2015. The morphology of the pillow lavas is similar to other historical eruption sites, so the greater depth and ambient pressure of this site had no apparent effect on the processes of lava extrusion and emplacement. This study reveals that some segments of the Mariana back-arc have active magmatic systems despite the relatively low spreading rate, and that other eruptions are possible in the near future.

Published
2018
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188. The human lymph node microenvironment unilaterally regulates T-cell activation and differentiation.

Author

Konstantin Knoblich, Sara Cruz Migoni, Susan M Siew, Elizabeth Jinks, Baksho Kaul, Hannah C Jeffery, Alfie T Baker, Muath Suliman, Katerina Vrzalikova, Hisham Mehenna, Paul G Murray, Francesca Barone, Ye H Oo, Philip N Newsome, Gideon Hirschfield, Deirdre Kelly, Steven P Lee, Biju Parekkadan, Shannon J Turley, and Anne L Fletcher

Subjects
Biology (General), QH301-705.5
Abstract

The microenvironment of lymphoid organs can aid healthy immune function through provision of both structural and molecular support. In mice, fibroblastic reticular cells (FRCs) create an essential T-cell support structure within lymph nodes, while human FRCs are largely unstudied. Here, we show that FRCs create a regulatory checkpoint in human peripheral T-cell activation through 4 mechanisms simultaneously utilised. Human tonsil and lymph node-derived FRCs constrained the proliferation of both naïve and pre-activated T cells, skewing their differentiation away from a central memory T-cell phenotype. FRCs acted unilaterally without requiring T-cell feedback, imposing suppression via indoleamine-2,3-dioxygenase, adenosine 2A Receptor, prostaglandin E2, and transforming growth factor beta receptor (TGFβR). Each mechanistic pathway was druggable, and a cocktail of inhibitors, targeting all 4 mechanisms, entirely reversed the suppressive effect of FRCs. T cells were not permanently anergised by FRCs, and studies using chimeric antigen receptor (CAR) T cells showed that immunotherapeutic T cells retained effector functions in the presence of FRCs. Since mice were not suitable as a proof-of-concept model, we instead developed a novel human tissue-based in situ assay. Human T cells stimulated using standard methods within fresh tonsil slices did not proliferate except in the presence of inhibitors described above. Collectively, we define a 4-part molecular mechanism by which FRCs regulate the T-cell response to strongly activating events in secondary lymphoid organs while permitting activated and CAR T cells to utilise effector functions. Our results define 4 feasible strategies, used alone or in combinations, to boost primary T-cell responses to infection or cancer by pharmacologically targeting FRCs.

Published
2018
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189. Decentralized Analysis of Brain Imaging Data: Voxel-Based Morphometry and Dynamic Functional Network Connectivity

Author

Harshvardhan Gazula, Bradley T. Baker, Eswar Damaraju, Sergey M. Plis, Sandeep R. Panta, Rogers F. Silva, and Vince D. Calhoun

Subjects
decentralized algorithms, COINSTAC, VBM, dFNC, multi-shot, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

In the field of neuroimaging, there is a growing interest in developing collaborative frameworks that enable researchers to address challenging questions about the human brain by leveraging data across multiple sites all over the world. Additionally, efforts are also being directed at developing algorithms that enable collaborative analysis and feature learning from multiple sites without requiring the often large data to be centrally located. In this paper, we propose two new decentralized algorithms: (1) A decentralized regression algorithm for performing a voxel-based morphometry analysis on structural magnetic resonance imaging (MRI) data and, (2) A decentralized dynamic functional network connectivity algorithm which includes decentralized group ICA and sliding-window analysis of functional MRI data. We compare results against those obtained from their pooled (or centralized) counterparts on the same data i.e., as if they are at one site. Results produced by the decentralized algorithms are similar to the pooled-case and showcase the potential of performing multi-voxel and multivariate analyses of data located at multiple sites. Such approaches enable many more collaborative and comparative analysis in the context of large-scale neuroimaging studies.

Published
2018
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192. Making space for children’s agency with playful learning

Author

Sara T. Baker, Janina Eberhart, and Soizic Le Courtois

Subjects
Aesthetics, Agency (sociology), Developmental and Educational Psychology, Playful learning, Early childhood, Space (commercial competition), Psychology, Education, Research evidence
Abstract

Playful learning has garnered supporters and research evidence, and also can be seen as nebulous and, therefore, reliant on practitioners’ intuitions in early education settings. In this paper, we ...

Published
2021

193. Descriptive Analysis of Forces Applied by Trained Clinicians During 2-Handed Instrument-Assisted Soft Tissue Mobilization

Author

Russell T. Baker, Taylor C Stevenson, Craig P. McGowan, Nickolai J P Martonick, James A Whitlock, Scott W. Cheatham, and Ashley J. Reeves

Subjects
Soft tissue mobilization, medicine.medical_specialty, Massage, Descriptive statistics, business.industry, Trainer, Physical Therapy, Sports Therapy and Rehabilitation, General Medicine, medicine.disease, Intervention (counseling), medicine, Physical therapy, Orthopedics and Sports Medicine, business, Physical therapist, Stroke
Abstract

Instrument-assisted soft tissue mobilization (IASTM) is a common intervention among clinicians. Despite its popularity, little is known about the forces applied by the clinician using the instruments during treatment. The purpose of this investigation was to examine the forces applied by trained clinicians using IASTM instruments during a simulated treatment. Eleven IASTM–trained (Graston Technique, Técnica Gavilán, or RockBlades) clinicians (physical therapists = 2, chiropractors = 2, athletic trainers = 7) participated in the study. Each clinician performed 75 two-handed strokes distributed evenly across 5 IASTM instruments on a skin simulant attached to a force plate. Instrument-assisted soft tissue mobilization stroke application was analyzed for peak normal forces and mean normal forces by stroke. We observed an average peak normal force of 8.9 N and mean normal force of 6.0 N across all clinicians and instruments. Clinicians and researchers may use the descriptive values as reference for the application of IASTM in practice and research.

Published
2021

194. FGFR2-IIIb Expression by Immunohistochemistry Has High Specificity in Cholangiocarcinoma with FGFR2 Genomic Alterations

Author

Gregory J. Gores, Hani M. Babiker, Alexander T. Baker, Daniel H. Ahn, George Vasmatzis, Benjamin R. Kipp, Rish K. Pai, Bertram L. Jacobs, James M Bogenberger, Nathalie Meurice, Rory L. Smoot, Oumar Barro, Marcela Salomao, Mansi Arora, Chelsae Dumbauld, Bolni Marius Nagalo, Michael T. Barrett, Mitesh J. Borad, Natalie Elliott, Heidi E. Kosiorek, Tanios Bekaii-Saab, Thomas DeLeon, Faaiq N Aslam, Yumei Zhou, Pedro Luiz Serrano Uson Junior, Mohammad Bassam Sonbol, Kenneth H. Buetow, Joachim L. Petit, Jun Yin, Aaron S. Mansfield, and Amit Mahipal

Subjects
musculoskeletal diseases, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, integumentary system, biology, Physiology, Gastroenterology, Clone (cell biology), Genomics, Context (language use), Hepatology, Molecular biology, Staining, stomatognathic diseases, Transthyretin, Internal medicine, embryonic structures, medicine, biology.protein, Immunohistochemistry, Antibody
Abstract

FGFR2 genomic alterations are observed in 10–20% of cholangiocarcinoma (CCA). Although FGFR2 fusions are an important actionable target, FGFR2 protein expression has not been thoroughly characterized. To evaluate FGFR2 protein expression in cholangiocarcinoma harboring FGFR2 genomic alterations. FGFR2 protein expression was evaluated in 99 CCA cases with two different antibodies. FGFR2 genomic alterations were confirmed via next-generating sequencing (NGS) or FISH. Primary objective was to determine the specificity and sensitivity of FGFR2 immunohistochemistry staining for detecting FGFR2 genomic alterations. Secondary objectives included overall FGFR2 immunohistochemistry staining in CCA patients, and evaluation of whether FGFR2 expression correlates with clinical outcomes including overall survival (OS), progression-free survival (PFS), and time-to-tumor recurrence (TTR). Immunohistochemistry staining with two antibodies against FGFR2, FPR2-D, and clone 98706 showed high accuracy (78.7% and 91.9%) and specificity (82.9% and 97.7%), and moderate sensitivity (53.9% and 57.1%), respectively, when compared with the standard methods for detecting FGFR2 genomic alterations. In a median follow-up of 72 months, there were no statistically significant differences in OS, PFS, and TTR, for patients with positive or negative FGFR2 staining. FGFR2 protein expression by immunohistochemistry has high specificity and therefore could be used to imply the presence of FGFR2 genomic alterations in the context of a positive test. In the case of a negative test, NGS or FISH would be necessary to ascertain cases with FGFR2 genomic alterations.

Published
2021

195. Comparing the Effects of Total Motion Release® to Stretching for Increases in Internal and External Rotation at the Shoulder

Author

Nicole Sordello, Jace Puckett, Russell T. Baker, Taylor Truesdell, Tenli Bright, and Jayme G. Baker

Subjects
Physics, 030222 orthopedics, 03 medical and health sciences, 0302 clinical medicine, External rotation, Rehabilitation, Motion (geometry), Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine, 030229 sport sciences, Mechanics
Abstract

Focused Clinical Question: What are the effects of Total Motion Release® on shoulder range of motion compared with stretching in overhead athletes? Clinical Bottom Line: Total Motion Release® significantly improved acute dominant and nondominant shoulder ROM compared with dynamic warm-up and stretching protocols. The application of Total Motion Release® was also found to produce significantly larger increases in shoulder ROM and took substantially less time to complete when compared with dynamic warm-up protocols.

Published
2021

196. Erratum: Searches for continuous gravitational waves from 15 supernova remnants and fomalhaut b with advanced LIGO (2019, ApJ, 875, 122)*

Author

A. Parida, S. S. Eikenberry, F. Frasconi, Chris A. Collins, R. Flaminio, Marcus E. Lower, Rosa Poggiani, V. Frey, E. K. Wessel, Nikhil Sarin, Odylio D. Aguiar, I. W. Martin, S. Farinon, P. Raffai, Andrew Matas, C. F. Da Silva Costa, M. A. Okada, G. Rutins, Graham Woan, Sebastiano Bernuzzi, D. Passuello, A. Cirone, H. S. Chen, Hyun Lee, J. D. Lough, K. Mason, S. A. Bilgili, E. C. Ferreira, Robert L. Byer, J. Calderón Bustillo, Sanjeev Dhurandhar, O. Halim, N. A. Robertson, Stuart Reid, F. J. Hayes, Patrick Godwin, N. Sennett, P. Kumar, Jacob Scheuer, B. R. Hall, J. Hanks, R. M. Martin, David A. Nichols, Edward K. Porter, J. G. Bartlett, Márton Tápai, K. W. Tsang, C. Horst, W. A. Campbell, Andreas Freise, C. V. Kalaghatgi, M. Rakhmanov, G. Pagano, Paul D. Lasky, J. W. Westhouse, M. C. Araya, Srishti Tiwari, C. Lazzaro, Patricia Schmidt, V. Brisson, Bernard F. Schutz, Li Ju, Matthew Pitkin, D. Cohen, Kiran Prasai, P. J. Veitch, S. A. Usman, C. Messenger, Liam Cunningham, E. A. M. Muniz, Daniel A. Shaddock, P. Gruning, Brittany Kamai, Riccardo Ciolfi, Alberto Vecchio, Geoffrey Mo, J. M. Fishner, Roman Schnabel, J. Hanson, M. Wade, M. Montani, P. Sharma, Héctor Estellés, N. Letendre, F. Ricci, A. Lenon, J. E. Brau, A. A. van Veggel, Richard Gray, Efim A. Khazanov, Peter T. H. Pang, C. Affeldt, G. Ballardin, Moritz Mehmet, A. A. Ciobanu, M. Granata, Minchuan Zhou, F. Marion, P. Brockill, Nancy Aggarwal, Hang Yu, P. G. Murray, Fabien Kéfélian, J. H. Hough, P. W. F. Forsyth, S. R. Thondapu, J. R. Palamos, Michele Zanolin, S. Mukherjee, T. J. Massinger, T. Vo, V. Kalogera, N. Leroy, G. D. Hammond, Javed Rana, H. Fong, G. Greco, M. Haney, T. A. Callister, Alec Mishkin, R. Cavalieri, S. R. P. Mohapatra, G. Giordano, K. Toland, A. K. Srivastava, A. E. Pace, H. Ohta, Vuk Mandic, B. Bécsy, M. Kasprzack, I. Dave, B. D. Lackey, R. L. Ward, Scott Coughlin, A.J. Weinstein, K. H. Lai, M. Phelps, H. S. Cho, L. Kuo, H. Yamamoto, E. Capocasa, M. Chan, S. Walsh, D. J. McManus, A. Schönbeck, B. Rajbhandari, Andrew Mehta, S. D. Linker, R. Robie, M. Fletcher, B. Hughey, R. D. Kennedy, José A. Font, Gregorio Carullo, S. Kumar, J. Prasad, H. K. Gulati, V. Raymond, Steven Bloemen, H. J. Bulten, Shiuh Chao, P. J. Sutton, N. Singh, C. Buy, Samuele Cortese, J. McIver, Vivishek Sudhir, P. A. Altin, A. Basti, N. A. Lockerbie, E. Schreiber, Charalampos Markakis, P. Grassia, Kipp Cannon, M. Steinke, P.H. Nguyen, Ryan N. Lang, Z. Doctor, Alyssa Garcia, J. H. Romie, Carlos O. Lousto, S. Sitmukhambetov, Alejandro Torres-Forné, A. Samajdar, D. M. Wysocki, T. Mistry, Mark A. Scheel, Charlie Hoy, F. Clara, M. A. Aloy, T. M. Evans, C. North, Thomas Dent, P. Corban, P. Ajith, B. Mours, Mandar Patil, Abhirup Ghosh, J. Neilson, Bala R. Iyer, Y. K. Lecoeuche, M. Muratore, Karsten Danzmann, Fabrizio Barone, N. Mukund, P. B. Covas, M. C. Edwards, T. Hinderer, Marta Colleoni, J. A. Giaime, Michael Pürrer, R. Pedurand, Benno Willke, A. Grado, D. C. Vander-Hyde, S. S. Y. Chua, J. Eichholz, J.-P. Coulon, Hua Wang, E. A. Chase, J. Betzwieser, G. Kang, L. R. Cominsky, O. A. Hannuksela, Z. Frei, A. Pal-Singh, S. Caride, Kevin Barkett, N. Bode, S. E. Gossan, Tristan Briant, R. Gustafson, Antoine Heidmann, Rana X. Adhikari, S. McCormick, C. Casentini, Slawomir Gras, D. Töyrä, H. Overmier, S. W. S. Ng, G. Wang, M. C. Heintze, J. S. Areeda, I. Belahcene, B. B. Lane, N. Mazumder, Maher Yazback, F. Donovan, J. Bosveld, N. A. Holland, N. V. Keerthana, M.L. Walker, C. Cahillane, L. Sun, M. C. Milovich-Goff, Dániel Barta, J. D. E. Creighton, V. Gayathri, P. Puppo, J.-D. Fournier, S. J. Kapadia, A. L. Stuver, A. S. Sengupta, H. W. Lee, I. Di Palma, S. T. Countryman, Francesco Pannarale, E. A. Huerta, J. L. Wright, Alessandra Corsi, B. W. Schulte, A. Rocchi, J. P. Zendri, R. Kashyap, Chandra Kant Mishra, R. Bhandare, Sylvain Marsat, Lee McCuller, T. Bulik, T. D. Abbott, O. Puncken, J. M. Gonzalez Castro, Philip F. Hopkins, C. Cocchieri, B. Goncharov, R. Birney, M. Kinley-Hanlon, I. Fiori, Shawn Rosofsky, Jun Liu, S. Raja, S. E. Strigin, D. Sellers, J. Meidam, Jeff R. Powell, Riccardo Sturani, D. Hoak, Stefan L. Danilishin, Patrick Brady, L. Matone, Haocun Yu, M. Landry, R. M. S. Schofield, Surabhi Sachdev, Christopher J. Moore, V. Avendano, R. Mittleman, Nelson Christensen, Geoffrey Lovelace, Soichiro Morisaki, John Worden, P. Couvares, Carl-Johan Haster, O. J. Piccinni, L. Rolland, C. L. Romel, Miriam Cabero, Alessandra Buonanno, L. Wallace, S. Biscoveanu, M. B. Shaner, Benjamin J. Owen, Alexander Urban, Antoni Ramos-Buades, V. V. Frolov, A. Singhal, F. Carbognani, Jordan Camp, R. L. Savage, A. S. Bell, M. Laxen, Anchal Gupta, A. Królak, B. D. Cheeseboro, G. Cerretani, P. J. Easter, J. F. J. van den Brand, M. J. Szczepańczyk, L. Di Fiore, E. Bonilla, S. Sunil, M. Tacca, Jessica Steinlechner, A. Neunzert, P.-F. Cohadon, M. Heurs, Irina Kowalska, E. Katsavounidis, Xiuling Li, C. I. Torrie, Jan Harms, Kazuhiro Agatsuma, Kin Sing Stephen Lee, Frank Ohme, M. Tonelli, R. De Rosa, Kwan-Lok Li, I. Nardecchia, Reed Essick, Martin Hendry, Cecilio García-Quirós, S. Kandhasamy, M. Fishbach, B. Sorazu, Christopher Wipf, Archisman Ghosh, A. P. Lundgren, Gabrielle Allen, E. J. Daw, M. Punturo, F. Garufi, Antonio Marquina, Surendra Nadh Somala, I. Dorrington, Robert J. McCarthy, T. A. Ferreira, R. Frey, Joseph Smith, S. Brunett, J. Zweizig, A. W. Heptonstall, E. L. Merilh, D. Barker, K. D. Giardina, Denis Martynov, Marco Bazzan, C. Ingram, L. Pinard, L. Naticchioni, Salvatore Vitale, R. Kirchhoff, B. L. Pearlstone, N. Man, Antonios Kontos, D. Moffa, J. J. McCann, J.-M. Isac, D. Hofman, Linqing Wen, A. Bisht, A. Kutynia, M. A. Page, Tyson Littenberg, Z. Tornasi, Junwei Cao, Sebastian Steinlechner, T. J. Slaven-Blair, S. ShyamSundar, C. Stachie, Hongyu Shen, O. de Varona, J. B. Kanner, Federico Ferrini, Lijing Shao, G. Vajente, S. M. Gaebel, Christopher P. L. Berry, S. H. Huttner, G. M. Harry, Andrea Chincarini, K. Venkateswara, Yuri Levin, C. Austin, C.D. Booth, M. Barsuglia, S. Appert, A. Giazotto, P. Shawhan, I. Ferrante, T. Z. Summerscales, A. Viceré, T. Huynh-Dinh, Fabio Hernandez, H. Cao, Ashok Kumar, D. J. Vine, W. Katzman, Alena Ananyeva, D. C. Coyne, Stanislav Babak, Rico K. L. Lo, Kendall Ackley, R. K. Nayak, F. Y. Khalili, Ken K. Y. Ng, A. Hreibi, M. Thomas, D. Fiorucci, Manuela Rizzo, H. Radkins, A. Bozzi, A. K. Prajapati, A. R. Wade, M. Agathos, M. Brinkmann, R. Quitzow-James, N. N. Janthalur, B. Sassolas, K. Izumi, L. Xiao, J. S. Lange, H. Y. Chia, M. C. Díaz, W. S. Kim, M. H. Wimmer, K. Haughian, S. Hochheim, M. Yvert, M. Nery, Marc Favata, L. E. Wade, Roger Jones, V. J. Roma, A. P. Spencer, G. Kuehn, C. M. Mow-Lowry, Sergey P. Vyatchanin, Andrew Melatos, M. Lorenzini, A. Masserot, M. Khursheed, Ettore Majorana, Robert Stone, Alessandro Nagar, D. D. Brown, Anthony A. Amato, N. van Bakel, Sebastien Biscans, P. Fulda, P. Charlton, F. Magaña-Sandoval, L. Aiello, M. Gosselin, A. R. Williamson, D. Huet, R. Green, M. Was, M. C. Tringali, A. K. Zadrożny, E. E. Cowan, V. Boschi, L. Zhang, J. H. Klika, M. Bawaj, J. Junker, M. van Beuzekom, K. W. Chung, David Coward, T. Hardwick, D. Steinmeyer, F. Travasso, M. Constancio, A. Allocca, Sascha Husa, G. Venugopalan, D.B. DeBra, Mikhail L. Gorodetsky, C. Whittle, Z. Khan, P. Ehrens, Paul M. Ricker, Y. Setyawati, H. Khan, S. E. Barclay, B. F. Whiting, F. Brighenti, C. Talbot, J. H. Briggs, J. Casanueva Diaz, D. H. Reitze, A. F. Brooks, P. J. Quinonez, V. Kringel, J. L. Willis, Ofek Birnholtz, M. F. Carney, P. Schale, R. Bonnand, Mariana Fazio, H. Vocca, C. Van Den Broeck, E. Sowell, Albrecht Rüdiger, Xing-Jiang Zhu, Jochen Kissel, Felice Sorrentino, V. Srivastava, D. Talukder, Michał Bejger, M. Standke, M. Croquette, David A. Williams, A. Effler, I. W. Harry, D. Mukherjee, Y. R. Chen, J. Jiang, Alessandro Bertolini, M. Fays, D. Moraru, J. C. Driggers, Matthew Evans, M. Bitossi, G. Bergmann, K. Wette, M. M. Hanke, Leo Singer, E. Cesarini, M. Hulko, T. D. Creighton, Eugeniy E. Mikhailov, Jörg Hennig, Eric Howell, A. Strunk, G. Vedovato, L. E. H. Datrier, D. B. Kozak, D. Stocks, C. Vorvick, P. Thomas, M. Arène, S. B. Anderson, Tim Dietrich, A. Perreca, G. Gemme, A. Di Lieto, R. A. Eisenstein, S. J. Chamberlin, Jishnu Suresh, G. D. Meadors, Z. A. Warden, R. Gouaty, T. Zelenova, Riccardo Bassiri, John J. Oh, M. Vasúth, Jonathan Cripe, N. Kijbunchoo, E. Cuoco, Sheelu Abraham, K. Kawabe, S. M. Aston, Michael W. Coughlin, G. D. O'Dea, Bruno Giacomazzo, Giuseppe Intini, M. Drago, Guenakh Mitselmakher, B. A. Boom, A. M. Sergeev, T. Etzel, J.-G. Ducoin, M. Eisenmann, A. Dmitriev, S. Leavey, Hai-Ping Cheng, A. Iess, L. K. Nuttall, D. Wilken, S. Katsanevas, R. Goetz, C. Adams, R. M. Blair, D. Sigg, S. W. Ballmer, D. M. Shoemaker, Binlei Ding, V. Bossilkov, Lindsay DeMarchi, I. Khan, K. Siellez, D. Sentenac, R. Macas, G. Billingsley, S. Macfoy, Sergio Gaudio, D. B. Tanner, A. Trovato, Olivier Minazzoli, Magnus Manske, M. Razzano, C. C. Yancey, F. Vetrano, Zachariah B. Etienne, Jennifer Watchi, E. Maros, R. C. Walet, V. P. Mitrofanov, R. Colgan, C. S. Unnikrishnan, G. Moreno, V. Kondrashov, P. Leaci, S. Meshkov, Seog Oh, S. P. Stevenson, Achamveedu Gopakumar, R. Inta, C. J. Richardson, S. Klimenko, M. J. Yap, C. Palomba, W. G. Anderson, G. Cella, F.L. Linde, P. Booker, L. Milano, S. C. Tait, N. V. Krishnendu, A. Pasqualetti, W. Del Pozzo, W. M. Farr, A. C. Green, Fausto Acernese, M. Korobko, B. C. Pant, C. Messick, J. Derby, J. Healy, K. A. Thorne, A. Cumming, M. Denys, M. Tse, S. Ascenzi, S. E. Dwyer, R. M. Magee, David Keitel, V. Germain, S. J. Cooper, Giacomo Ciani, K. Rao, Yongjung Kim, Peter Weßels, I. A. Bilenko, L. Haegel, David J. Ottaway, B. P. Abbott, H. Vahlbruch, J. C. Mills, E. K. Gustafson, K. Riles, J. Y. Vinet, H. Middleton, S. Doravari, H. Heitmann, Piotr Jaranowski, M. S. Shahriar, P. Ruggi, M. Weinert, H. A. G. Gabbard, D. M. Macleod, Karan Jani, B. L. Swinkels, Arunava Mukherjee, S. Privitera, L. Glover, Imre Bartos, Isabel Cordero-Carrión, H. Qi, E. Genin, J. Zhang, F. Baldaccini, B. U. Gadre, A. Lartaux-Vollard, B. Irwin, R. Shink, L. Rei, Huang-Wei Pan, Gijs Nelemans, S. Vass, Kenneth A. Strain, Jimin George, R. Coyne, C. Gray, G. H. Ogin, T. J. Shaffer, M. Sieniawska, Fabrice Matichard, A. Paoli, K. A. Santiago, F. Fidecaro, G. M. Guidi, G. Cagnoli, Arnold Miller, H. N. Isa, Suvadeep Bose, V. Tiwari, V. Quetschke, Yann Bouffanais, Martin M. Fejer, L. F. Ortega, D. Lumaca, M. Pedraza, R. Bork, S. Ghonge, Y. Minenkov, P. Bacon, K. AultONeal, K. Chakravarti, E. D. Hall, L. Sammut, Lionel London, D. George, R. K. Lanza, Y. Boetzel, Alexander C. Jenkins, P. Dupej, Eric B. Flynn, Z. Márka, M. Mantovani, T. Prestegard, D. W. Yeeles, Xie Chen, A. Markowitz, Fabio Marchesoni, P. Hello, Samuel Deléglise, M. Merzougui, A. Fernandez-Galiana, S. M. Scott, M. Obergaulinger, Turlough P. Downes, F. Cavalier, A. Ain, R. J. Trudeau, K. Holt, Chunglee Kim, L. van der Schaaf, S. A. Pai, C. De Rossi, W. Parker, A. Gennai, Rahul Kumar, Harald P. Pfeiffer, Milan Gupta, G. Dálya, B. Gateley, G. Cho, J. C. Bayley, Aaron Buikema, V. Sandberg, E. J. King, M. J. Cowart, S. Koley, M. Boer, G. Mendell, S. J. Jadhav, B. Idzkowski, V. Loriette, V. Skliris, J. K. Blackburn, E. Chassande-Mottin, Shubhanshu Tiwari, G. Koekoek, L. Trozzo, C. Pankow, P. M. Meyers, Koh Ueno, Christian Pedersen, Albert Lazzarini, Kyungmin Kim, N. Koper, H. Wittel, M. Deenadayalan, B. O'Reilly, A. W. Jones, Sheila Rowan, S. G. Schwalbe, D. Pascucci, R. De Pietri, S. Mitra, T. Sadecki, W. Ren, Rocco Romano, John D. Scott, J. Z. Wang, S. Grunewald, R. Prasanna, R. Cotesta, R. G. Ormiston, S. Kaufer, Rainer Weiss, David E. McClelland, Paul J. Groot, M. Zevin, R. A. Mercer, S. Ossokine, Jinsook Kim, Rebecca Fisher, J. Li, A. M. Holgado, H. Fair, Samaya Nissanke, X. Liu, M. A. Bizouard, K. Bossie, John Veitch, J. Lehmann, Al Imran Malik, K. G. Arun, J. D. Tasson, C. K. Cheong, J. R. Gair, M. Fitz-Axen, B. K. Berger, S. D'Antonio, N. Arnaud, K. E. Ramirez, W. Z. Korth, Daniel E. Holz, F. Di Renzo, Torrey Cullen, B. J. J. Slagmolen, Archana Pai, F. Paoletti, Vijay Varma, M. MacInnis, Marco Romanelli, M. Fyffe, F. Cipriano, David Blair, C. Fee, Gabriela Gonzalez, F. Aubin, G. Stratta, Jesper Munch, K. R. Corley, A. Mullavey, T. J. N. Nelson, J. Birch, S. Bae, P. Rapagnani, F. J. Raab, D. Tuyenbayev, B. Patricelli, D. S. Wu, Margaret Millhouse, S. Barnum, D. Buskulic, S. G. Gaonkar, E. Coccia, M. E. Zucker, C. Graef, B. A. Weaver, Xiaohui Fan, J. G. Rollins, Richard O'Shaughnessy, B. Barr, M. De Laurentis, D. Ugolini, P. Clearwater, G. Valdes, David Jones, M. R. Ganija, L.-W. Wei, Haixing Miao, G. Bogaert, R. Taylor, P. Popolizio, Koji Arai, Ryan Lynch, A. D. Viets, D. Meacher, E. J. Fauchon-Jones, E. J. Sanchez, S. Ponrathnam, G. A. Prodi, K. L. Dooley, Fangchen Feng, Lisa Barsotti, Kris Ryan, E. A. Quintero, Marco Cavaglia, J.J. Bero, Leo Tsukada, David H. Shoemaker, M. Lormand, D. J. Stops, S. Karki, Anirban Dasgupta, E. Z. Hamilton, R. J. G. Jonker, J. S. H. Lee, T. Dal Canton, J. Warner, R. Passaquieti, D. Verkindt, Mairi Sakellariadou, G. Pillant, S. H. R. Yuen, Keith Rose, K. S. Karvinen, F. Martelli, C. Rajan, Pablo Cerdá-Durán, Peter R. Saulson, V. Sequino, Tenglin Li, R. DeSalvo, D. Estevez, B. Pang, Paul T. Baker, O. V. Palashov, Sean T. McWilliams, D. Rosińska, J. C. Barayoga, V. Fafone, R. Tso, Jonathan Richardson, F. Piergiovanni, Chang-Hwan Lee, N. Sanchis-Gual, N. Radulescu, L. Mereni, Terry G. McRae, S. Mastrogiovanni, Richard J. Abbott, L. G. Prokhorov, Patrick M. Koch, S. Antier, S. Banagiri, A. Grant, D. Chatterjee, T. L. Lam, A. Pele, A. Chiummo, Nergis Mavalvala, Alessandro Longo, Richard J. Oram, M. Davier, Jerome Degallaix, François Bondu, F. Badaracco, Sebastian Khan, B. C. Barish, Hartmut Grote, R. J. E. Smith, John A. Clark, Ben Farr, Christophe Collette, Ho-Gyu Lee, G. Losurdo, Luca Gammaitoni, R. Metzdorff, C. J. Perez, B. D. O'Brien, M. K. M. Bader, O. Chaibi, Devon S. Johnson, C. Bradaschia, P. Oppermann, Neil J. Cornish, S. Frasca, M. Di Giovanni, Ik Siong Heng, Kai Staats, F-L. Lin, L. Conti, M. Chaturvedi, S. Márka, Stephen Fairhurst, Carl Blair, Peter Aufmuth, T. Di Girolamo, V. Mangano, A. L. Miller, S. Ghosh, László Á. Gergely, A. Macquet, P. Astone, B. Lantz, Daichi Tsuna, K. Mogushi, P. J. King, J. T. Whelan, S. G. Crowder, J. Feicht, Joey Shapiro Key, J. R. Sanders, António Alves da Silva, Q. Chu, S. V. Angelova, L. Magaña Zertuche, Lili Yang, Laura Cadonati, D. A. Steer, M. Branchesi, Zefeng Zhou, D. Y. T. Pong, L. Kleybolte, E. Massera, F. Wellmann, Edward Seidel, O. E. S. Sauter, J. Woehler, S. Chung, K. S. Phukon, A. Avila-Alvarez, Chad Hanna, A. Bramley, C. Kimball, J. Oberling, M. Pirello, K. Gill, Walter Winkler, A. S. Markosyan, Harald Lück, J. Bidler, M. Cho, G. Gaur, S. C. McGuire, J. F. Read, F. Nocera, C. Zhao, Alicia M. Sintes, S. Di Pace, K. Haris, T. Zhang, N. Demos, Thibaut Jacqmin, T. Regimbau, I. Maksimovic, G. Hemming, S. M. Koehlenbeck, M. Saleem, M. Oliver, Douglas Davis, Geraint Pratten, E. Goetz, Tarun Souradeep, Andrea Taracchini, D. Bersanetti, G. Ashton, S. Penn, J. V. van Heijningen, Yu Wang, F. Thies, G. L. Mansell, V. Dattilo, Edwin J. Son, Eric Thrane, Stefan Hild, Y. Ma, A. Brillet, C. Michel, M. Vardaro, Sarah Caudill, T. D. Knowles, F. Robinet, V. B. Adya, J. K. Wofford, F. Cleva, M. P. Ross, T. B. Edo, M. Pichot, Maximiliano Isi, E. M. Gretarsson, Ying Guo, D. Beniwal, Peter Fritschel, Wenxiao Wang, M. Masso-Reid, S. Kwang, L. E. Sanchez, Enrico Calloni, G. Traylor, Thomas Corbitt, L. Salconi, C. A. Costa, Zhihui Du, Laboratoire des matériaux avancés (LMA), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), (Astro)-Particles Physics, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
Physics, [PHYS]Physics [physics], 010504 meteorology & atmospheric sciences, Gravitational wave, Astronomy, Astronomy and Astrophysics, 01 natural sciences, LIGO, Supernova, Fomalhaut, Space and Planetary Science, 0103 physical sciences, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract

Equation (5) of the published article?(Abbott et al. 2019) is in error; it should read (Formula Presented) The upper limits on ò presented in the published article are unaffected by this error.

Published
2021

197. Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration: In vivo structural and functional assessment

Author

Xiaojun Yu, Sangamesh G. Kumbar, Ohan S. Manoukian, Jenna M. Bartley, Jiana T. Baker, Swetha Rudraiah, and Michael R. Arul

Subjects
Pathology, medicine.medical_specialty, Neurofilament, QH301-705.5, 0206 medical engineering, Biomedical Engineering, Nerve guidance conduit, Schwann cell, Neurotrophic factor, Peripheral nerve regeneration, 02 engineering and technology, Article, Biomaterials, Myelin, Neurotrophic factors, medicine, Biology (General), Materials of engineering and construction. Mechanics of materials, business.industry, Regeneration (biology), Functional recovery, 021001 nanoscience & nanotechnology, Sciatic nerve transection, 020601 biomedical engineering, medicine.anatomical_structure, TA401-492, Sciatic nerve, Small-molecule drug delivery, 0210 nano-technology, business, Biotechnology, Reinnervation
Abstract

Peripheral nerve injuries account for roughly 3% of all trauma patients with over 900,000 repair procedures annually in the US. Of all extremity peripheral nerve injuries, 51% require nerve repair with a transected gap. The current gold-standard treatment for peripheral nerve injuries, autograft repair, has several shortcomings. Engineered constructs are currently only suitable for short gaps or small diameter nerves. Here, we investigate novel nerve guidance conduits with aligned microchannel porosity that deliver sustained-release of neurogenic 4-aminopyridine (4-AP) for peripheral nerve regeneration in a critical-size (15 mm) rat sciatic nerve transection model. The results of functional walking track analysis, morphometric evaluations of myelin development, and histological assessments of various markers confirmed the equivalency of our drug-conduit with autograft controls. Repaired nerves showed formation of thick myelin, presence of S100 and neurofilament markers, and promising functional recovery. The conduit's aligned microchannel architecture may play a vital role in physically guiding axons for distal target reinnervation, while the sustained release of 4-AP may increase nerve conduction, and in turn synaptic neurotransmitter release and upregulation of critical Schwann cell neurotrophic factors. Overall, our nerve construct design facilitates efficient and efficacious peripheral nerve regeneration via a drug delivery system that is feasible for clinical applications., Graphical abstract Image 1, Highlights • Nerve guidance conduit platform with tunable scaffold properties for repair and regeneration of large-gap nerve injuries. • Sustained 4-aminopyridine release amplifies neurotrophic factor release by Schwann cells to promote axon regeneration. • Longitudinally aligned scaffold pores and controllable physicochemical properties provide guidance for axon regeneration. • Critical-size rat sciatic nerve defect healing both structurally and functionally resembled autograft control treatment. • Innovative and transformative scaffold technology imbued with structural and functional features for tissue regeneration. • Scaffold enable tailorable release profiles for small molecules proteins and electrical stimulation for tissue regeneration.

Published
2021

198. Cotton Water Use Efficiency under Two Different Deficit Irrigation Scheduling Methods

Author

Jeffrey T. Baker, Dennis C. Gitz, John E. Stout, and Robert J. Lascano

Subjects
deficit irrigation, canopy temperature, cotton, yield, water use efficiency, Agriculture
Abstract

Declines in Ogallala aquifer levels used for irrigation has prompted research to identify methods for optimizing water use efficiency (WUE) of cotton (Gossypium hirsutum L). In this experiment, conducted at Lubbock, TX, USA in 2014, our objective was to test two canopy temperature based stress indices, each at two different irrigation trigger set points: the Stress Time (ST) method with irrigation triggers set at 5.5 (ST_5.5) and 8.5 h (ST_8.5) and the Crop Water Stress Index (CWSI) method with irrigation triggers set at 0.3 (CWSI_0.3) and 0.6 (CWSI_0.6). When these irrigation triggers were exceeded on a given day, the crop was deficit irrigated with 5 mm of water via subsurface drip tape. Also included in the experimental design were a well-watered (WW) control irrigated at 110% of potential evapotranspiration and a dry land (DL) treatment that relied on rainfall only. Seasonal crop water use ranged from 353 to 625 mm across these six treatments. As expected, cotton lint yield increased with increasing crop water use but lint yield WUE displayed asignificant (p ≤ 0.05) peak near 3.6 to 3.7 kg ha−1 mm−1 for the ST_5.5 and CWSI_0.3 treatments, respectively. Our results suggest that WUE may be optimized in cotton with less water than that needed for maximum lint yield.

Published
2015
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200. Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup

Author

Ashley A. Huggins, C. Lexi Baird, Melvin Briggs, Sarah Laskowitz, Samar Foudra, Courtney Haswell, Delin Sun, Lauren E. Salminen, Neda Jahanshad, Sophia I. Thomopoulos, Dick J. Veltman, Jessie L. Frijling, Miranda Olff, Mirjam van Zuiden, Saskia B.J. Koch, Laura Nawjin, Li Wang, Ye Zhu, Gen Li, Dan J. Stein, Johnathan Ipser, Soraya Seedat, Stefan du Plessis, Leigh L. van den Heuvel, Benjamin Suarez-Jimenez, Xi Zhu, Yoojean Kim, Xiaofu He, Sigal Zilcha-Mano, Amit Lazarov, Yuval Neria, Jennifer S. Stevens, Kerry J. Ressler, Tanja Jovanovic, Sanne JH van Rooij, Negar Fani, Anna R. Hudson, Sven C. Mueller, Anika Sierk, Antje Manthey, Henrik Walter, Judith K. Daniels, Christian Schmahl, Julia I. Herzog, Pavel Říha, Ivan Rektor, Lauren A.M. Lebois, Milissa L. Kaufman, Elizabeth A. Olson, Justin T. Baker, Isabelle M. Rosso, Anthony P. King, Isreal Liberzon, Mike Angstadt, Nicholas D. Davenport, Scott R. Sponheim, Seth G. Disner, Thomas Straube, David Hofmann, Rongfeng Qi, Guang Ming Lu, Lee A. Baugh, Gina L. Forster, Raluca M. Simons, Jeffrey S. Simons, Vincent A. Magnotta, Kelene A. Fercho, Adi Maron-Katz, Amit Etkin, Andrew S. Cotton, Erin N. O’Leary, Hong Xie, Xin Wang, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Steven Bruce, Josh Cisler, Marisa Ross, Ryan J. Herringa, Daniel W. Grupe, Jack B. Nitschke, Richard J. Davidson, Christine Larson, Terri A. deRoon-Cassini, Carissa W. Tomas, Jacklynn M. Fitzgerald, Jennifer Urbano Blackford, Bunmi O. Olatunji, William S. Kremen, Michael J. Lyons, Carol E. Franz, Evan M. Gordon, Geoffrey May, Steven M. Nelson, Chadi G. Abdallah, Ifat Levy, Ilan Harpaz-Rotem, John H. Krystal, Emily L. Dennis, David F. Tate, David X. Cifu, William C. Walker, Elizabeth A. Wilde, Ian H. Harding, Rebecca Kerestes, Paul M. Thompson, and Rajendra Morey

Abstract

BackgroundThe cerebellum critically contributes to higher-order cognitive and emotional functions such fear learning and memory. Prior research on cerebellar volume in PTSD is scant and has neglected neuroanatomical subdivisions of the cerebellum that differentially map on to motor, cognitive, and affective functions.MethodsWe quantified cerebellar lobule volumes using structural magnetic resonance imaging in 4,215 adults (PTSD n= 1640; Control n=2575) across 40 sites from the from the ENIGMA-PGC PTSD working group. Using a new state-of-the-art deep-learning based approach for automatic cerebellar parcellation, we obtained volumetric estimates for the total cerebellum and 28 subregions. Linear mixed effects models controlling for age, gender, intracranial volume, and site were used to compare cerebellum total and subregional volume in PTSD compared to healthy controls. The Benjamini-Hochberg procedure was used to control the false discovery rate (p-FDR< .05).ResultsPTSD was associated with significant grey and white matter reductions of the cerebellum. Compared to controls, people with PTSD demonstrated smaller total cerebellum volume. In addition, people with PTSD showed reduced volume in subregions primarily within the posterior lobe (lobule VIIB, crus II), but also the vermis (VI, VIII), flocculonodular lobe (lobule X), and cerebellar white matter (allp-FDR< 0.05). Effects of PTSD on volume were consistent, and generally more robust, when examining symptom severity rather than diagnostic status.ConclusionsThese findings implicate regionally specific cerebellar volumetric differences in the pathophysiology of PTSD. The cerebellum appears to play an important role in high-order cognitive and emotional processes, far beyond its historical association with vestibulomotor function. Further examination of the cerebellum in trauma-related psychopathology will help to clarify how cerebellar structure and function may disrupt cognitive and affective processes at the center of translational models for PTSD.

Published
2022

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