14,828 results on '"T, Inoue"'
Search Results
152. SAT-107 BONE MARROW STROMAL CELL ANTIGEN-1 MEDIATES ACUTE KIDNEY INJURY AND KIDNEY FIBROSIS
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J. Yao, Masaomi Nangaku, L. Huang, K. Ishihara, Y. Wada, D. Rosin, T. Inoue, R. Inagi, and M. Okusa
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Pathology ,medicine.medical_specialty ,Antigen ,Nephrology ,business.industry ,Kidney fibrosis ,Acute kidney injury ,Medicine ,Bone Marrow Stromal Cell ,business ,medicine.disease - Published
- 2019
153. WS06-2 Initial results evaluating the add-on effect of the novel CFTR corrector PTI-801 in cystic fibrosis subjects
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C. Mortelliti, Jennifer L. Taylor-Cousar, Joseph M. Pilewski, T. Inoue, S. Wilson, P.-S. Lee, Patrick A. Flume, C. Milla, J. Miller, J. Jiang, Geoffrey Gilmartin, D. Layish, Manu Jain, and Steven M. Rowe
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,Internal medicine ,Pediatrics, Perinatology and Child Health ,medicine ,business ,medicine.disease ,Gastroenterology ,Cystic fibrosis - Published
- 2019
154. Optimal KAATSU pressure increases muscle activities during low-load exercise in an elderly female frail patient receiving transcatheter aortic valve implantation
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H, Ishizaka, primary, A, Uematsu, additional, R, Takahashi, additional, H, Ogawa, additional, I, Shibasaki, additional, T, Sawaguchi, additional, T, Nasuno, additional, S, Toyoda, additional, S, Yamaguchi, additional, T, Yasuda, additional, Y, Sato, additional, H, Fukuda, additional, T, Inoue, additional, and T, Nakajima, additional
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- 2019
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155. Objective tumor response to denosumab in patients with giant cell tumor of bone: a multicenter phase II trial
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Y. Asami, T. Inoue, Takafumi Ueda, Hiroyuki Tsuchiya, Yoshihiro Matsumoto, T. Yoneda, Yoshihiro Nishida, Shigeki Kakunaga, and Hideo Morioka
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Adult ,Male ,musculoskeletal diseases ,Pathology ,medicine.medical_specialty ,Stromal cell ,Osteolysis ,Adolescent ,Bone Neoplasms ,primary bone tumor ,Miscellaneous Tumors ,Young Adult ,objective tumor response ,Osteoclast ,medicine ,Humans ,Prospective Studies ,Aged ,Neoplasm Staging ,Giant Cell Tumor of Bone ,Bone Density Conservation Agents ,biology ,business.industry ,RANKL ,denosumab ,RANK Ligand ,Original Articles ,Hematology ,Middle Aged ,Prognosis ,medicine.disease ,medicine.anatomical_structure ,Denosumab ,Oncology ,Giant cell ,Cancer research ,biology.protein ,Female ,Neoplasm Recurrence, Local ,business ,Follow-Up Studies ,medicine.drug ,Giant-cell tumor of bone - Abstract
A RANK ligand-specific inhibitor, denosumab, was predicted to reduce osteolysis and control disease progression in patients with giant cell tumor of bone (GCTB). We report, for the first time, the results of the response of GCTB to denosumab obtained from a prospective independent imaging assessment. The findings demonstrate that denosumab has robust clinical efficacy in the treatment of GCTB., Background Giant cell tumor of bone (GCTB) is a rare primary bone tumor, characterized by osteoclast-like giant cells that express receptor activator of nuclear factor-kappa B (RANK), and stromal cells that express RANK ligand (RANKL), a key mediator of osteoclast activation. A RANKL-specific inhibitor, denosumab, was predicted to reduce osteolysis and control disease progression in patients with GCTB. Patients and methods Seventeen patients with GCTB were enrolled. Patients were treated with denosumab at 120 mg every 4 weeks, with a loading dose of 120 mg on days 8 and 15. To evaluate efficacy, objective tumor response was evaluated prospectively by an independent imaging facility on the basis of prespecified criteria. Results The proportion of patients with an objective tumor response was 88% based on best response using any tumor response criteria. The proportion of patients with an objective tumor response using individual response criteria was 35% based on the modified Response Evaluation Criteria in Solid Tumors (RECIST) criteria, 82% based on the modified European Organization for Research and Treatment of Cancer (EORTC) criteria, and 71% based on inverse Choi criteria. The median time of study treatment was 13.1 months. Conclusion The findings demonstrate that denosumab has robust clinical efficacy in the treatment of GCTB.
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- 2015
156. University of Pennsylvania 7th annual conference on statistical issues in clinical trials: Current issues regarding the use of biomarkers and surrogate endpoints in clinical trials (afternoon panel discussion session)
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Jarcy Zee, Pamela A. Shaw, William Mietlowski, Ying Huang, Eve H. Pickering, Jeremy M. G. Taylor, Michael W. Kattan, Herbert I. Weisberg, Lurdes Y. T. Inoue, Songbai Wang, H. M James Hung, Susan S. Ellenberg, and Stuart G. Baker
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Pharmacology ,Gerontology ,Clinical trial ,business.industry ,Medicine ,General Medicine ,business - Published
- 2015
157. Survival Benefit of the Primary Prevention Implantable Cardioverter-Defibrillator Among Older Patients
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Arthur J. Moss, J. Thomas Bigger, Daniel B. Mark, Gust H. Bardy, Alan H. Kadish, Sana M. Al-Khatib, Paul Dorian, Richard C. Steinman, Joo Yoon Han, Peter J. Kudenchuk, Rex Edwards, Alfred E. Buxton, Al Hallstrom, Paul L. Hess, Kerry L. Lee, Gillian D Sanders, Lurdes Y. T. Inoue, and Riccardo Cappato
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Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Electric Countershock ,Comorbidity ,Kaplan-Meier Estimate ,Patient Readmission ,Risk Assessment ,Article ,Sudden cardiac death ,Risk Factors ,Interquartile range ,Internal medicine ,Credible interval ,Humans ,Medicine ,Aged ,Proportional Hazards Models ,Retrospective Studies ,Clinical Trials as Topic ,Chi-Square Distribution ,business.industry ,Hazard ratio ,Age Factors ,Bayes Theorem ,Middle Aged ,Implantable cardioverter-defibrillator ,medicine.disease ,Defibrillators, Implantable ,Surgery ,Primary Prevention ,Clinical trial ,Death, Sudden, Cardiac ,Logistic Models ,Treatment Outcome ,Heart failure ,Linear Models ,Female ,Cardiomyopathies ,Cardiology and Cardiovascular Medicine ,business ,Multicenter Automatic Defibrillator Implantation Trial - Abstract
Background— The impact of patient age on the risks of death or rehospitalization after primary prevention implantable cardioverter-defibrillator (ICD) placement is uncertain. Methods and Results— Data from 5 major ICD trials were merged: the Multicenter Automatic Defibrillator Implantation Trial I (MADIT-I), the Multicenter UnSustained Tachycardia Trial (MUSTT), the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II), the Defibrillators in Nonischemic Cardiomyopathy Treatment Evaluation Trial (DEFINITE), and the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). Median age at enrollment was 62 (interquartile range 53–70) years. Compared with their younger counterparts, older patients had a greater burden of comorbid illness. In unadjusted exploratory analyses, ICD recipients were less likely to die than nonrecipients in all age groups: among patients aged Conclusions— In this analysis, the survival benefit of the ICD exists but is attenuated with increasing age. The latter finding may be because of the higher burden of comorbid illness, competing causes of death, or limited sample size of older patients. There was no evidence that age modifies the association between ICD treatment and rehospitalization.
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- 2015
158. Application of a global nonhydrostatic model with a stretched-grid system to regional aerosol simulations around Japan
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T. Inoue, Atsushi Shimizu, Chris Fook Sheng Ng, Daisuke Goto, Junya Uchida, Akinori Takami, Tie Dai, Haruo Tsuruta, Teruyuki Nakajima, Nobuo Sugimoto, Kayo Ueda, Masaki Satoh, Toshimasa Ohara, Hirofumi Tomita, and Shota Misawa
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Horizontal resolution ,Global wind patterns ,NICAM ,lcsh:QE1-996.5 ,Global model ,Aerosol ,lcsh:Geology ,chemistry.chemical_compound ,chemistry ,Climatology ,Environmental science ,Grid system ,Precipitation ,Sulfate - Abstract
An aerosol-coupled global nonhydrostatic model with a stretched-grid system has been developed. Circulations over the global and target domains are simulated with a single model, which includes fine meshes covering the target region to calculate meso-scale circulations. The stretched global model involves lower computational costs to simulate atmospheric aerosols with fine horizontal resolutions compared with a global uniform nonhydrostatic model, whereas it may require higher computational costs compared with the general regional models, because the stretched-grid system calculates inside and outside the target domain. As opposed to general regional models, the stretched-grid system requires neither a nesting technique nor lateral boundary conditions. In this study, we developed a new-type regional model for the simulation of aerosols over Japan, especially in the Kanto areas surrounding Tokyo, with a maximum horizontal resolution of approximately 10 km. This model usually reproduces temporal variations and their averages of the observed weather around Japan. This model generally reproduces monthly mean distributions of the observed sulfate and SO2 over East Asia, with high correlations (R > 0.6), but the underestimation of the simulated concentrations by 40% (sulfate) and 50% (SO2). Their underestimation of the simulated sulfate and SO2 concentrations over East Asia are strongly affected by their underestimation in China and possibly by the uncertainty of the simulated precipitation around Japan. In the Kanto area, this model succeeds in simulating the wind patterns and the diurnal transitions around the center of the Kanto area, although it is inadequate to simulate the wind patterns and the diurnal transitions at some sites located at the edge of the Kanto area and surrounded on three sides by mountains, e.g., Maebashi, mainly due to the insufficient horizontal resolution. This model also generally reproduces both diurnal and synoptic variations of the observed and/or a regional aerosol-transport model, WRF-CMAQ, simulated EC, sulfate, and SO2 concentrations in the Kanto area, especially with their high correlation (R > 0.5) at Komae/Tokyo. Although the aerosol module used in this study is relatively simplified compared to the general regional aerosol models, this study reveals that our proposed model with the stretched-grid system can be applicable for the regional aerosol simulation.
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- 2015
159. A Simple System to Predict Mortality in Medical Intensive Care Unit
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Marina Politi Okoshi, Marcos F. Minicucci, Paula S. Azevedo, Kurt Schnitz, Luciano Santos, Roberto M. T. Inoue, Sergio A. R. Paiva, Bruna Paola Murino Rafacho, Polyanne Garcia, Daniella R. Duarte, Bertha F. Polegato, and Leonardo A. M. Zornoff
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Pediatrics ,medicine.medical_specialty ,Environmental Engineering ,Multivariate analysis ,Receiver operating characteristic ,APACHE II ,business.industry ,Mortality rate ,Regression analysis ,medicine.disease ,Industrial and Manufacturing Engineering ,Intensive care ,Medicine ,Hypoalbuminemia ,Prognostic equation ,business - Abstract
Background: Advances in critical care have increased survival chances and the demand for a scientific approach to outcome prediction. The present study aimed to investigate the associations of clinical information, demographic and laboratory data with mortality; and to elaborate and validate a regression equation for mortality prediction in a medical intensive care unit (ICU). Methods: This study included 202 patients and took place in a medical ICU at the Botucatu Medical School Hospital, Brazil. In Phase 1, 123 patients admitted to ICU between September 2003 and October 2004 was retrospectively analyzed and allowed equation elaboration. In Phase 2, the mortality equation was prospectively applied in 79 patients consecutively admitted to ICU between August and December 2006. Results: Among Phase 1 patients, 55% were males and mean age was 5819 years. Mortality Original Research Article Rafacho et al.; BJMMR, 10(1): 1-8, 2015; Article no.BJMMR.19176 2 rate was 29%. Multivariate analysis revealed that shock (p=0.002) and hypoalbuminemia (p=0.024) were associated with higher mortality rate. When regression equation was applied in Phase 2 patients, higher equation values were shown for nonsurvivors (0.512; -1.008 -0.512) than for survivors (-1.008; -1.290 -1.008) (p=0.03). The equation also had good precision, 1.8% (IC95%; 1.1-4.7), and low bias, -3.1% (IC95%; -27.1 -20.8). Areas under the receiver operating characteristic (ROC) curve showed no statistical differences between APACHE II (0.750.06) and the equation (0.660.07) (p=0.27). Conclusions: Our data suggest that a simple and accurate prognostic equation can be used to predict ICU mortality.
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- 2015
160. Efficacy of combined treatment with alendronate (ALN) and eldecalcitol, a new active vitamin D analog, compared to that of concomitant ALN, vitamin D plus calcium treatment in Japanese patients with primary osteoporosis
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F. Fukuda, Satoshi Ikeda, Akinori Sakai, H. Saito, Masako Ito, T. Tomomitsu, Hiroshi Tsurukami, Toshitaka Nakamura, Hideki Mizunuma, and T. Inoue
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Vitamin ,musculoskeletal diseases ,medicine.medical_specialty ,Bone density ,medicine.medical_treatment ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,Eldecalcitol ,Bone remodeling ,chemistry.chemical_compound ,Internal medicine ,Vitamin D and neurology ,medicine ,Bone mineral density ,Bisphosphonate ,Vitamin D ,Bone mineral ,business.industry ,medicine.disease ,Endocrinology ,chemistry ,Original Article ,business ,Bone turnover markers - Abstract
Summary Combined treatment with alendronate and eldecalcitol was found to be more effective in reducing the bone turnover markers and increasing bone mineral density than alendronate treatment with vitamin D3 and calcium supplementation in the osteoporotic patients. Introduction We compared the clinical efficacy and safety of combined treatment with alendronate plus eldecalcitol (ALN + ELD) with those of treatment with ALN plus vitamin D and calcium (ALN + VitD). Methods Osteoporotic 219 patients were randomly assigned to the ALN + ELD, or the ALN + VitD group. Primary endpoint was the inter-group differences in lumbar spine BMD (L-BMD) at patient’s last visit. Secondary endpoints included the differences in BMD at other sites and the bone turnover marker (BTM) levels. Results L-BMD, total hip BMD and femoral neck (FN-BMD) increased from baseline by 7.30, 2.41, and 2.70 % in the ALN + ELD group, and by 6.52, 2.27, and 1.18 % in the ALN + VitD group, respectively. Inter-group differences of the L-BMD and total hip BMD values were not significant. The increase of the FN-BMD was larger in the ALN + ELD group than the ALN + VitD group. Reductions of the BTMs were greater in the ALN + ELD group than the ALN + VitD group. Interaction of the percent increase of the L-BMD with the baseline values of the BTMs was observed in the ALN + VitD group only. The increases of the FN-BMD in patients with lower baseline values of type-I-collagen C-telopeptide (sCTX) and serum 25(OH) D levels
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- 2015
161. Detection of quantitative trait loci for heading traits inBrassica rapausing different heading types of Chinese cabbage
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Nakao Kubo, T. Kondo, Masashi Hirai, and T. Inoue
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Heading (navigation) ,Head (linguistics) ,Fresh weight ,food and beverages ,Horticulture ,Quantitative trait locus ,Biology ,Diameter ratio ,Botany ,F2 population ,Brassica rapa ,Genetics ,Cultivar - Abstract
SummaryBrassica species exhibit a wide diversity of leaf and floral morphologies.There are many cultivars of heading Chinese cabbage in East Asia, but the genetic mechanism of head formation remains unclear. In this study, we generated an F2 population derived from a cross between two Chinese cabbages of different heading type (i.e., the cylindrical-head type, ‘Chihili 70’, and the round-head type, inbred line ‘Y-54’). The F2 population was grown in 2010 and in 2011 to score morphological traits for head formation [i.e., HT, degree of head top leaf overlap; PW, plant fresh weight (FW); HW, head FW; HW:PW, head FW to plant FW ratio; HH, head height; HD, head diameter; HH:HD, head height to head diameter ratio; and HDS, head density].We constructed linkage maps in both years so that quantitative trait locus (QTL) analyses could be performed. Thirteen and ten QTLs were detected in 2010 and in 2011, respectively. QTL clusters for the different heading traits were found on linkage groups A1, A5, A7, and A8 in ...
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- 2015
162. Outcomes of Implantable Cardioverter-Defibrillator Use in Patients With Comorbidities
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Riccardo Cappato, J. Thomas Bigger, Arthur J. Moss, Alan H. Kadish, Rex Edwards, Benjamin A. Steinberg, Peter J. Kudenchuk, Sana M. Al-Khatib, Daniel B. Mark, Richard C. Steinman, Gillian D Sanders, Alfred P. Hallstrom, Gust H. Bardy, Alfred E. Buxton, Kerry L. Lee, Lurdes Y. T. Inoue, Paul Dorian, and JooYoon Han
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medicine.medical_specialty ,Ejection fraction ,business.industry ,medicine.medical_treatment ,Hazard ratio ,Atrial fibrillation ,Implantable cardioverter-defibrillator ,medicine.disease ,Comorbidity ,Sudden cardiac death ,Internal medicine ,Heart failure ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Multicenter Automatic Defibrillator Implantation Trial - Abstract
Objectives The aim of this study was to determine if the benefit of implantable cardioverter-defibrillators (ICDs) is modulated by medical comorbidity. Background Primary prevention ICDs improve survival in patients at risk for sudden cardiac death. Their benefit in patients with significant comorbid illness has not been demonstrated. Methods Original, patient-level datasets from MADIT I (Multicenter Automatic Defibrillator Implantation Trial I), MADIT II, DEFINITE (Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation), and SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial) were combined. Patients in the combined population (N = 3,348) were assessed with respect to the following comorbidities: smoking, pulmonary disease, diabetes, peripheral vascular disease, atrial fibrillation, ischemic heart disease, and chronic kidney disease. The primary outcome was overall mortality, using the hazard ratio (HR) of time to death for patients receiving an ICD versus no ICD by extent of medical comorbidity, and adjusted for age, sex, race, left ventricular ejection fraction, use of antiarrhythmic drugs, beta-blockers, and angiotensin-converting enzyme inhibitors. Results Overall, 25% of patients (n = 830) had Conclusions Patients with extensive comorbid medical illnesses may experience less benefit from primary prevention ICDs than those with less comorbidity; implantation should be carefully considered in sick patients. Further study of ICDs in medically complex patients is warranted.
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- 2014
163. Development of a neutrino detector and electronics for precise measurement of neutrino cross-section ratios
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L. Nicola, O. Volcye, M. A. M. Rayner, Yannick Favre, T. Ovsjannikova, J. Imber, T. Koga, A. Minamino, A. Bonnemaison, Franck Cadoux, Oleg Mineev, M. M. Khabibullin, Yu.A. Kudenko, Etam Noah, B. Qualin, A. Kostin, Y. Seiya, M. Gonin, Masashi Yokoyama, T. Inoue, K. Nakamura, S. V. Cao, S. Parsa, Tsuyoshi Nakaya, Y. Hayato, O. Ferrera, Th. A. Muller, A. K. Ichikawa, F. Gastaldi, A. Mofodiev, M. Licciardi, Takashi Kobayashi, A. Hiramoto, N. Chikuma, A. N. Khotjantsev, A. Blondel, K. Kin, S. Suvorov, Koji Yamamoto, K. Karadzhov, T. Ishida, T. Hayashino, N. Yersov, O. Drapier, R. Cornat, M. Antonova, A. Izmaylov, R. Tamura, Y. Azuma, Laboratoire Leprince-Ringuet (LLR), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)
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application specific integrated circuits ,Spartan6 FPGA ,dimension: 3 ,Physics::Instrumentation and Detectors ,data acquisition ,plastic targets ,readout electronics ,cross section: ratio ,cross section ratio ,photomultipliers ,neutrino cross-section ratios ,01 natural sciences ,nuclear electronics ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Data acquisition ,36-channel ASIC ,time resolution ,Charged current ,three-dimensional grid structure ,FPGA ,field programmable gate arrays ,Physics ,water target ,Mesons ,J-PARC Lab ,Detector ,J-PARC T59 experiment ,charged current interaction ,Detectors ,WAGASCI detector ,data acquisition system ,solid scintillation detectors ,neutrino: detector ,Neutrino detector ,neutrino detector ,Scintillators ,frontend electronics ,Structural beams ,Neutrino ,backend electronics ,performance ,plastic scintillator bars ,water ,scintillation counter: plastics ,Scintillator ,J-PARC neutrino beamline ,03 medical and health sciences ,Optics ,SPIROC2D ASIC chip ,neutrino beam ,Neutrino sources ,0103 physical sciences ,Bars ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Field-programmable gate array ,three-dimensional reconstruction ,010308 nuclear & particles physics ,business.industry ,neutrino detection ,position sensitive particle detectors ,Beamline ,silicon radiation detectors ,16-deep analog memory array ,integrated circuit: design ,electronics: readout ,business ,32-channel MPPCs - Abstract
International audience; The J-PARC T59 experiment, named WAGASCI, has been developing a neutrino detector to measure a cross section ratio of charged current interaction on nucleus between water and plastic targets with uncertainties of a few percent at the J-PARC neutrino beamline. The WAGASCI detector adopts three-dimensional grid structure of 3mm-thick plastic scintillator bars around water target, to perform three-dimensional reconstruction of a particle trajectory, to improve the acceptance for large angle tracks. The light from scintillator is read out by MPPCs. An array of 32-channel MPPCs has been newly developed for this experiment. The total number of channels for the WAGASCI detector is 1280. The SPIROC2D ASIC chip, developed by OMEGA, has been employed in the frontend electronics. SPIROC2D is an auto-triggered, bi-gain, 36-channel ASIC, allowing the measurement of the charge from one to 2000 photoelectrons and the time with 100ps resolution. It contains a 16-deep analog memory array, which allows 16 hits to be stored in an acquisition gate. The backend electronics utilize Spartan6 FPGAs. The system to synchronize the data acquisition to the beam timing from J-PARC has been also developed and the data acquisition system has also been developed. The data taking with neutrino beam has started since autumn October 16, 2017.
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- 2017
164. Gain measurement of 60 GHz CMOS on-chip dipole antenna by proton irradiation
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Akira Matsuzawa, H. Yagi, Kenichi Okada, Ning Li, T. Inoue, and Takuichi Hirano
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010302 applied physics ,Materials science ,Silicon ,Proton ,business.industry ,020208 electrical & electronic engineering ,chemistry.chemical_element ,02 engineering and technology ,Substrate (electronics) ,01 natural sciences ,law.invention ,Dipole ,chemistry ,CMOS ,law ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Optoelectronics ,Dipole antenna ,Antenna gain ,Antenna (radio) ,business - Abstract
In this paper, a 60 GHz CMOS on-chip dipole antenna with loss-reduced silicon substrate, which had been proposed and simulated by the authors, was measured and gain improvement of approximately 9 dB was obtained. In the antenna, rectangular region with 500 μm × 1000 μm around the dipole is irradiated by proton and conductivity is reduced from 10 S/m (10 Ω cm) to 0.1 S/m (1 kΩ cm). Antenna gain of −4 dBi could be achieved.
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- 2017
165. Physicochemical Habitability Conditions for the Genus Halophila in Nakagusuku Bay, Japan
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M. Uchimura and T. Inoue
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Oceanography ,Halophila ,Genus ,Habitability ,Ecology ,Biology ,biology.organism_classification ,Bay - Published
- 2017
166. Predicting appropriate shocks in patients with heart failure: Patient level meta-analysis from SCD-HeFT and MADIT II
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Alan H. Kadish, Gust H. Bardy, Arthur J. Moss, Jeanne E. Poole, J. Thomas Bigger, Kerry L. Lee, Daniel B. Mark, Alfred E. Buxton, Lurdes Y. T. Inoue, Peter J. Kudenchuk, Emily P. Zeitler, Paul Dorian, Joo Yoon Han, Riccardo Cappato, Gillian D Sanders, Daniel J. Friedman, and Sana M. Al-Khatib
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Logistic regression ,Article ,Sudden cardiac death ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Physiology (medical) ,Internal medicine ,Medicine ,Humans ,Multicenter Studies as Topic ,030212 general & internal medicine ,Aged ,Randomized Controlled Trials as Topic ,Heart Failure ,Electroshock ,Ejection fraction ,business.industry ,Middle Aged ,Implantable cardioverter-defibrillator ,medicine.disease ,Defibrillators, Implantable ,Meta-analysis ,Predictive value of tests ,Heart failure ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Multicenter Automatic Defibrillator Implantation Trial - Abstract
Background No precise tools exist to predict appropriate shocks in patients with a primary prevention ICD. We sought to identify characteristics predictive of appropriate shocks in patients with a primary prevention implantable cardioverter defibrillator (ICD). Methods Using patient-level data from the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) and the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT), we identified patients with any appropriate shock. Clinical and demographic variables were included in a logistic regression model to predict appropriate shocks. Results There were 1,463 patients randomized to an ICD, and 285 (19%) had ≥1 appropriate shock over a median follow-up of 2.59 years. Compared with patients without appropriate ICD shocks, patients who received any appropriate shock tended to have more severe heart failure. In a multiple logistic regression model, predictors of appropriate shocks included NYHA class (NYHA II vs I: OR 1.65, 95% CI 1.07-2.55; NYHA III vs I: OR 1.74, 95% CI 1.10-2.76), lower LVEF (per 1% change) (OR 1.04, 95% CI 1.02-1.06), absence of beta blocker therapy (OR 1.61, 95% CI 1.23-2.12), and single chamber ICD (OR 1.67, 95% CI 1.13-2.45). Conclusion In this meta-analysis of patient level data from MADIT-II and SCD-HeFT, higher NYHA class, lower LVEF, no beta blocker therapy, and single chamber ICD (versus dual chamber) were significant predictors of appropriate shocks. This article is protected by copyright. All rights reserved
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- 2017
167. P5830Thoracoscopic left atrial appendectomy can prevent patients with atrial fibrillation from thromboembolism without anticoagulants
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T. Ohtsuka, Y. Suematsu, and T. Inoue
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medicine.medical_specialty ,Left atrial ,business.industry ,Internal medicine ,medicine ,Cardiology ,Atrial fibrillation ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2017
168. Implantable cardioverter-defibrillators in heart failure patients with reduced ejection fraction and diabetes
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Christopher B. Fordyce, Daniel B. Mark, Alan H. Kadish, Alfred E. Buxton, Lurdes Y. T. Inoue, J. Thomas Bigger, Abhinav Sharma, Gust H. Bardy, Arthur J. Moss, Eric D. Peterson, Justin A. Ezekowitz, Paul Dorian, Peter J. Kudenchuk, G. Michael Felker, Lauren B. Cooper, Daniel J. Friedman, Gillian D Sanders, Riccardo Cappato, Jeanne E. Poole, Kerry L. Lee, Sana M. Al-Khatib, and Richard C. Steinman
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Cardiomyopathy ,Comorbidity ,030204 cardiovascular system & hematology ,Sudden cardiac death ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Diabetes mellitus ,medicine ,Diabetes Mellitus ,Humans ,030212 general & internal medicine ,Heart Failure ,Ejection fraction ,business.industry ,Incidence ,Hazard ratio ,Stroke Volume ,Middle Aged ,medicine.disease ,Implantable cardioverter-defibrillator ,United States ,Defibrillators, Implantable ,Primary Prevention ,Survival Rate ,Death, Sudden, Cardiac ,Heart failure ,Female ,Cardiology and Cardiovascular Medicine ,business ,Multicenter Automatic Defibrillator Implantation Trial - Abstract
Aim There is limited information on the outcomes after primary prevention implantable cardioverter-defibrillator (ICD) implantation in patients with heart failure (HF) and diabetes. This analysis evaluates the effectiveness of a strategy of ICD plus medical therapy vs. medical therapy alone among patients with HF and diabetes. Methods and results A patient-level combined-analysis was conducted from a combined dataset that included four primary prevention ICD trials of patients with HF or severely reduced ejection fractions: Multicenter Automatic Defibrillator Implantation Trial I (MADIT I), MADIT II, Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE), and Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT). In total, 3359 patients were included in the analysis. The primary outcome of interest was all-cause death. Compared with patients without diabetes (n = 2363), patients with diabetes (n = 996) were older and had a higher burden of cardiovascular risk factors. During a median follow-up of 2.6 years, 437 patients without diabetes died (178 with ICD vs. 259 without) and 280 patients with diabetes died (128 with ICD vs. 152 without). ICDs were associated with a reduced risk of all-cause mortality among patients without diabetes [hazard ratio (HR) 0.56, 95% confidence interval (CI) 0.46-0.67] but not among patients with diabetes (HR 0.88, 95% CI 0.7-1.12; interaction P = 0.015). Conclusion Among patients with HF and diabetes, primary prevention ICD in combination with medical therapy vs. medical therapy alone was not significantly associated with a reduced risk of all-cause death. Further studies are needed to evaluate the effectiveness of ICDs among patients with diabetes.
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- 2017
169. New York Heart Association class and the survival benefit from primary prevention implantable cardioverter defibrillators: A pooled analysis of 4 randomized controlled trials
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Alfred E. Buxton, Daniel J. Friedman, Arthur J. Moss, Lurdes Y. T. Inoue, J. Thomas Bigger, Daniel B. Mark, Emily P. Zeitler, Gust H. Bardy, Paul Dorian, Riccardo Cappato, Jeanne E. Poole, Kerry L. Lee, Gillian D Sanders, Peter J. Kudenchuk, Joo Yoon Han, Sana M. Al-Khatib, Richard C. Steinman, and Alan H. Kadish
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medicine.medical_specialty ,New York Heart Association Class ,medicine.medical_treatment ,Cardiology ,New York ,030204 cardiovascular system & hematology ,Global Health ,Article ,Sudden cardiac death ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,030212 general & internal medicine ,Intensive care medicine ,Societies, Medical ,Randomized Controlled Trials as Topic ,Heart Failure ,Ejection fraction ,business.industry ,Hazard ratio ,medicine.disease ,Implantable cardioverter-defibrillator ,Defibrillators, Implantable ,Primary Prevention ,Survival Rate ,Death, Sudden, Cardiac ,Heart failure ,Conventional PCI ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background Primary prevention implantable cardioverter defibrillator (ICD) reduce all-cause mortality by reducing sudden cardiac death. There are conflicting data regarding whether patients with more advanced heart failure derive ICD benefit owing to the competing risk of nonsudden death. Methods We performed a patient-level meta-analysis of New York Heart Association (NYHA) class II/III heart failure patients (left ventricular ejection fraction ≤35%) from 4 primary prevention ICD trials (MADIT-I, MADIT-II, DEFINITE, SCD-HeFT). Bayesian-Weibull survival regression models were used to assess the impact of NYHA class on the relationship between ICD use and mortality. Results Of the 2,763 patients who met study criteria, 68% (n = 1,867) were NYHA II and 52% (n = 1,435) were randomized to an ICD. In a multivariable model including all study patients, the ICD reduced mortality (hazard ratio [HR] 0.65, 95% posterior credibility interval [PCI]) 0.40-0.99). The interaction between NYHA class and the ICD on mortality was significant (posterior probability of no interaction = .036). In models including an interaction term for the NYHA class and ICD, the ICD reduced mortality among NYHA class II patients (HR 0.55, PCI 0.35-0.85), and the point estimate suggested reduced mortality in NYHA class III patients (HR 0.76, PCI 0.48-1.24), although this was not statistically significant. Conclusions Primary prevention ICDs reduce mortality in NYHA class II patients and trend toward reducing mortality in the heterogeneous group of NYHA class III patients. Improved risk stratification tools are required to guide patient selection and shared decision making among NYHA class III primary prevention ICD candidates.
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- 2017
170. Primary Prevention Implantable Cardioverter Defibrillators in Patients With Nonischemic Cardiomyopathy: A Meta-analysis
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Gillian D Sanders, Sana M. Al-Khatib, Gust H. Bardy, Lurdes Y. T. Inoue, Alan H. Kadish, Gregg C. Fonarow, Daniel B. Mark, Jose A. Joglar, and Kerry L. Lee
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Brief Report ,Hazard ratio ,Cardiomyopathy ,030204 cardiovascular system & hematology ,Implantable defibrillator ,medicine.disease ,Implantable cardioverter-defibrillator ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,Meta-analysis ,Emergency medicine ,Cardiology ,Clinical endpoint ,Medicine ,030212 general & internal medicine ,Cardiology and Cardiovascular Medicine ,business ,Cause of death - Abstract
Importance Conflicting data have emerged on the efficacy of implantable cardioverter defibrillators (ICDs) for primary prevention of sudden cardiac death (primary prevention ICDs) in patients with nonischemic cardiomyopathy. Objective To investigate the association of primary prevention ICDs with all-cause mortality in patients with nonischemic cardiomyopathy. Data Sources PubMed was searched from January 1, 2000, through October 31, 2016, for the terms implantable defibrillator OR implantable cardioverter defibrillator AND non-ischemic cardiomyopathy . Additional references were identified from bibliographies of pertinent articles and queries to experts in this field. Study Selection Inclusion criteria consisted of a randomized clinical trial design and comparison of the ICD with medical therapy (control) in at least 100 patients with nonischemic cardiomyopathy. In addition, studies had to report on all-cause mortality during a follow-up period of at least 12 months and be published in English. The search yielded 10 studies, of which only 1 met the inclusion criteria. A search of bibliographies of pertinent articles and queries of experts in this field led to 3 additional studies. Data Extraction and Synthesis The PRISMA guidelines were used to abstract data and assess data quality and validity. Data were pooled using fixed- and random-effects models. Main Outcomes and Measures The primary end point was all-cause mortality. Before data collection started, primary prevention ICDs were hypothesized to reduce all-cause mortality among patients with nonischemic cardiomyopathy. Results Four randomized clinical trials met the selection criteria and included 1874 unique patients; 937 were in the ICD group and 937 in the control group. Pooling data from these trials showed a significant reduction in all-cause mortality with an ICD (hazard ratio, 0.75; 95% CI, 0.61-0.93; P = .008; P = .87 for heterogeneity). Conclusions and Relevance Primary prevention ICDs are efficacious at reducing all-cause mortality among patients with nonischemic cardiomyopathy. These findings support professional guidelines that recommend the use of ICDs in such patients.
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- 2017
171. A joint model for multistate disease processes and random informative observation times, with applications to electronic medical records data
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Rebecca A. Hubbard, Jane M. Lange, Vladimir N. Minin, and Lurdes Y. T. Inoue
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Statistics and Probability ,General Immunology and Microbiology ,Markov chain ,medicine.diagnostic_test ,Estimation theory ,business.industry ,Applied Mathematics ,Sampling (statistics) ,Sample (statistics) ,General Medicine ,Disease ,computer.software_genre ,General Biochemistry, Genetics and Molecular Biology ,Medicine ,Mammography ,Observational study ,Data mining ,General Agricultural and Biological Sciences ,business ,computer ,Panel data - Abstract
Multistate models are used to characterize individuals’ natural histories through diseases with discrete states. Observational data resources based on electronic medical records pose new opportunities for studying such diseases. However, these data consist of observations of the process at discrete sampling times, which may either be pre-scheduled and non-informative, or symptom-driven and informative about an individual’s underlying disease status. We have developed a novel joint observation and disease transition model for this setting. The disease process is modeled according to a latent continuous-time Markov chain; and the observation process, according to a Markov-modulated Poisson process with observation rates that depend on the individual’s underlying disease status. The disease process is observed at a combination of informative and non-informative sampling times, with possible misclassification error. We demonstrate that the model is computationally tractable and devise an expectation-maximization algorithm for parameter estimation. Using simulated data, we show how estimates from our joint observation and disease transition model lead to less biased and more precise estimates of the disease rate parameters. We apply the model to a study of secondary breast cancer events, utilizing mammography and biopsy records from a sample of women with a history of primary breast cancer.
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- 2014
172. Effects of Root Water Uptake Efficiency on Soil Water Utilization in Wheat (Triticum aestivumL.) under Severe Drought Environments
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Ping An, Junichi Kashiwagi, M. Inagaki, T. Inoue, Y. Morito, and Yutaka Jitsuyama
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Biomass (ecology) ,Root morphology ,Agronomy ,Water flow ,Soil water ,Drought tolerance ,Water uptake ,food and beverages ,Plant Science ,Root system ,Biology ,Agronomy and Crop Science ,Transpiration - Abstract
Improving wheat production in drought-prone areas is the key to meet the increasing global demand. The importance of root traits, especially, the structural traits such as root volume and rooting depth, has been well recognized to confer drought tolerance in wheat. However, generation of knowledge on root water uptake efficiency and its application in drought adaptation breeding had lagged behind. The main objective of this study was to evaluate the relevance of the root water uptake efficiency to biomass production under acute soil water deficit in six wheat genotypes. Pot experiments were conducted under polythene rainout shelters at Hokkaido University, Sapporo, Japan, in 2010 and 2011. Under drought that was measured as smaller critical fraction of transpirable soil water (FTSW), the root systems with less reduction water uptake efficiency were found to postpone the relative transpiration decline. This study also showed the existence of substantial genotypic variation on the root water uptake efficiency among the wheat genotypes. The expression of hydrophobic root morphology under drought environments, however, did not explain the results obtained on the relative root water uptake efficiency, indicating other regulative mechanisms in operation for the regulation of transverse water flow in the roots. These findings provide new understanding of drought adaptation in wheat through variations in the root water uptake efficiency.
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- 2014
173. Expression profiles of NOS isoforms in gingiva of nNOS knockout mice
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T. Inoue, Hiroki Watanabe, J. Sasaki, Takaaki Yanagisawa, Y. Ishizuka, M. Ishioka, and S. Shintani
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Male ,Gene isoform ,Pathology ,medicine.medical_specialty ,Nitric Oxide Synthase Type III ,Arginine ,Gingiva ,Nitric Oxide Synthase Type II ,Nitric Oxide Synthase Type I ,In situ hybridization ,Biology ,Gene Expression Regulation, Enzymologic ,Nitric oxide ,Mice ,chemistry.chemical_compound ,Enos ,medicine ,Animals ,Mice, Knockout ,Lamina propria ,Cell Biology ,General Medicine ,biology.organism_classification ,Molecular biology ,Isoenzymes ,Nitric oxide synthase ,medicine.anatomical_structure ,chemistry ,Knockout mouse ,biology.protein ,Female ,Developmental Biology - Abstract
Nitric oxide is a gaseous molecule associated with many distinct physiological functions, and is derived from l -arginine catalyzed by nitric oxide synthase (NOS). Nitric oxide synthase has 3 isoforms: nNOS, iNOS and eNOS. Although these NOS isoforms are believed to play an important role in gingival tissue, little information is available on their morphological dynamics. The aim of this study was to investigate the profiles of NOS isoforms in deficiency of nNOS in gingiva of mice. Twelve male (6 normal (C57BL/6) and 6 nNOS knockout) mice were used. All mice were 5-week-old, weighing approximately 20–25 g each. After sacrifice, the jaws of the mice were removed by mechanical means and specimens analyzed by histology, in situ hybridization and immunohistochemistry. Immunohistochemical observation revealed positive staining for iNOS and eNOS, especially in lamina propria. Similar results in the mRNA expression levels were shown by in situ hybridization analysis. It may suggest that iNOS and eNOS compensated nNOS deficiency in the gingiva of nNOS knockout mice.
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- 2014
174. Efforts by Reconstruction Agency to Rebuild Housing and Cities
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T. Inoue
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General Materials Science - Published
- 2014
175. Surgical strategy of esophageal resection and reconstruction for aortoesophageal fistula
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Satoshi Suzuki, Yutaka Okita, Taro Oshikiri, Tetsu Nakamura, H. Takahashi, H. Tanaka, Yoshihiro Kakeji, Masayuki Yamamoto, Shingo Kanaji, Takahiro Yamazato, and T. Inoue
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Adult ,Male ,medicine.medical_specialty ,Surgical strategy ,medicine.medical_treatment ,Aortic Diseases ,Patient characteristics ,030204 cardiovascular system & hematology ,Resection ,03 medical and health sciences ,Esophageal Fistula ,0302 clinical medicine ,Aortoesophageal fistula ,Ileum ,Chart review ,Medicine ,Humans ,Thoracotomy ,Cecum ,Aged ,Retrospective Studies ,Aged, 80 and over ,Vascular Fistula ,business.industry ,Gastroenterology ,General Medicine ,Middle Aged ,Plastic Surgery Procedures ,Sternotomy ,Surgery ,Esophagectomy ,Survival Rate ,Jejunum ,030228 respiratory system ,Median sternotomy ,Female ,Vascular Grafting ,business ,Omentum ,Vascular Surgical Procedures - Abstract
Aortoesophageal fistula is a critical and life-threatening disease. The cardiovascular strategy for graft replacement has been widely discussed. However, the surgical strategy of esophageal resection and reconstruction for aortoesophageal fistula has rarely been discussed. The objective of this study is to establish a surgical strategy and procedure of esophageal resection and reconstruction for aortoesophageal fistula. Eleven patients with aortoesophageal fistula who underwent aortic graft replacement and esophagectomy between 2008 and 2015 at Kobe University Hospital were enrolled in this study. Patient characteristics, operative methods, and clinical outcomes were obtained by retrospective chart review. All 11 patients underwent graft replacement, esophagectomy, and omental wrapping. Ten esophagectomies were simultaneously accomplished in the same operative field as aortic graft replacement. Seven patients underwent subtotal esophagectomy from a left thoracotomy, and three patients underwent upper hemiesophagectomy from a median sternotomy. The other patient underwent staged esophagectomy from a right thoracotomy. Seven of 11 patients (63.6%) successfully underwent staged esophageal reconstruction. Pedicled jejunal transfer with supercharge and superdrainage were performed in six patients, and ileocecal reconstruction was performed in one patient. Median survival time in the patients with esophageal reconstruction was 21 months while that in the patients without esophageal reconstruction was 10 months. Six of 7 patients (85.7%) who underwent esophageal reconstructions were alive. Our surgical strategy for aortoesophageal fistula, which includes simultaneous graft replacement and esophagectomy in the same operative field and staged reconstruction by pedicled jejunal transfer to ensure omental wrapping, is feasible and promising.
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- 2016
176. P.112Two murine models for tubular aggregate myopathy with mutations in Stim1 and Orai1
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Satoru Noguchi, T. Inoue, Y. Inoue, I. Nishino, M. Ogasawara, J. Lee, Megumu Ogawa, and Y. Endo
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Aggregate (composite) ,Neurology ,ORAI1 ,Chemistry ,Pediatrics, Perinatology and Child Health ,medicine ,STIM1 ,Neurology (clinical) ,medicine.symptom ,Myopathy ,Molecular biology ,Genetics (clinical) - Published
- 2019
177. P1.09-03 Clinicopathological Characteristics for NSCLC Harboring EGFR Exon 20 Insertion
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K. Morikawa, K. Kakinuma, Masamichi Mineshita, and T. Inoue
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Pulmonary and Respiratory Medicine ,Exon ,Oncology ,business.industry ,Cancer research ,Medicine ,business - Published
- 2019
178. SUN-059 Significance of fibroblast growth factor-23 (FGF23) level in hemodialysis patients
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M. Tashiro, K. Okada, J. Minakuchi, K. Kawahara, S. Kawashima, H. Shima, K. Miya, and T. Inoue
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Oncology ,Fibroblast growth factor 23 ,medicine.medical_specialty ,Nephrology ,business.industry ,medicine.medical_treatment ,Internal medicine ,medicine ,Hemodialysis ,business - Published
- 2019
179. SAT-137 NON-CANONICAL CHOLINERGIC ANTI-INFLAMMATORY PATHWAY-MEDIATED ACTIVATION OF PERITONEAL MACROPHAGES INDUCES HES1 AND BLOCKS KIDNEY INJURY
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S. Tanaka, D. Rosin, M. Okusa, M. Nanagaku, T. Inoue, C. Abe, R. Inagi, and Y. Wada
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Non canonical ,Nephrology ,business.industry ,Cancer research ,Kidney injury ,Medicine ,HES1 ,business ,Cholinergic anti-inflammatory pathway - Published
- 2019
180. SUN-155 Mitochondrial DNA leakage causes inflammation via the cGAS-STING axis in cisplatin-induced acute kidney injury
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H. Maekawa, Hiroshi Nishi, Masaomi Nangaku, R. Inoue, T. Inoue, and R. Inagi
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Cisplatin ,Mitochondrial DNA ,business.industry ,Acute kidney injury ,Inflammation ,medicine.disease ,Sting ,Nephrology ,medicine ,Cancer research ,medicine.symptom ,business ,Leakage (electronics) ,medicine.drug - Published
- 2019
181. WS06-1 Initial results evaluating combinations of the novel CFTR corrector PTI-801, potentiator PTI-808, and amplifier PTI-428 in cystic fibrosis subjects
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Alex Horsley, Patrick A. Flume, J. Miller, Tacjana Pressler, Sivagurunathan Sutharsan, S. Wilson, S. van Koningsbruggen-Rietschel, Damian G. Downey, Isabelle Fajac, Jennifer L. Taylor-Cousar, G. Poirier, Manu Jain, P.-S. Lee, J. Jiang, T. Inoue, G. Gilmartin, and Carsten Schwarz
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Pulmonary and Respiratory Medicine ,business.industry ,Pediatrics, Perinatology and Child Health ,medicine ,Cancer research ,Potentiator ,medicine.disease ,business ,Cystic fibrosis - Published
- 2019
182. Design of a half-size 3T REBCO superconducting magnet with active shielding coils for MRI
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T. Matsuda, S. Sato, S. Otake, S. Yokoyama, T. Inoue, H. Miura, and Y. Morita
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Materials science ,business.industry ,Electromagnetic shielding ,Optoelectronics ,Superconducting magnet ,business - Published
- 2019
183. Efficacy and safety of complete intra-ureteral stent placement versus conventional stent placement in relieving ureteral stent-related symptoms: A randomized, prospective, single-blinded, multicenter clinical trial
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T. Yoshida, T. Inoue, M. Taguchi, T. Matsuzaki, T. Murota, H. Kinoshita, and T. Matsuda
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03 medical and health sciences ,0302 clinical medicine ,Urology ,030232 urology & nephrology - Published
- 2019
184. Gas exchange of root hemi-parasite Striga hermonthica and its host Sorghum bicolor under short-term soil water stress
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Yasuo Yamauchi, Hiroaki Samejima, Abdel Gabbar T. Babiker, Yukihiro Sugimoto, T. Inoue, and A. H. Eltayeb
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Striga hermonthica ,Stomatal conductance ,Host (biology) ,food and beverages ,Plant Science ,Horticulture ,Biology ,Photosynthesis ,biology.organism_classification ,Sorghum ,Agronomy ,Soil water ,Respiration rate ,Transpiration - Abstract
The gas exchange of the upper fully expanded leaf of the root parasite Striga hermonthica and of its host Sorghum bicolor was measured under wet and dry conditions to identify the mechanisms of the devastating effects of the parasite on its hosts under drought. The short-term water stress severely reduced photosynthetic rate in infected sorghum, but less in S. hermonthica. Soil water stress did not affect leaf respiration rate in either S. hermonthica or infected sorghum. This suggests that under dry conditions both infected sorghum and S. hermonthica decreased autotrophic carbon gain. The transpiration rate of S. hermonthica, a major driving force for assimilate uptake from the host, was higher and less affected by water stress than that of infected sorghum. Stomatal density on the abaxial surfaces of the leaves was higher in S. hermonthica than in sorghum. Both S. hermonthica infection and water stress decreased stomatal conductance of the sorghum leaves. S. hermonthica, irrespective of soil water status, had greater stomatal aperture on the adaxial and abaxial surfaces of its leaves than infected sorghum. These results indicate that the higher transpiration rate of S. hermonthica even under water stress, achieved through higher stomatal density on the abaxial surfaces of the leaves and greater stomatal aperture on both surfaces of the leaves, may induce the maintenance of water and solute transfers from the host to the parasite leading to severe damage to the host under drought.
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- 2013
185. Medullary Bone in Goose Remains: A Reliable Indicator of Domestic Individual in Non-Breeding Regions
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S. Yashima, T. Inoue, and Masaki Eda
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Bony tissue ,Archeology ,Medullary cavity ,Ecology ,Biology ,Subarctic climate ,food.food ,First generation ,food ,Goose ,Anthropology ,biology.animal ,Seasonal breeder ,Domestic goose ,Domestication - Abstract
The ideal indicator of domestic individuals is the presence of traits that must appear in the first generation of the domestic lineage. Most wild geese are migratory, breeding in the subarctic zone and wintering in the temperate zone. If goose remains from archaeological sites in a non-breeding region are from individuals shown to have died during the breeding season, the bones are likely to be from domestic birds. Medullary bone is secondary woven bony tissue formed in the marrow cavity of breeding female birds. It develops 1 or 2 weeks before the first egg is produced and disappears 1 or 2 weeks after egg production. As wild geese remain in their breeding regions for about 3 months after egg production, medullary bone would be expected to disappear before birds arrive at the stopover and wintering areas. Therefore, the presence of medullary bone in goose remains found in non-breeding regions would be a reliable indicator of domestic birds. In this study, we examined goose (Anserini spp.) remains from 15 archaeological sites in Japan (3400 bc to 1912 ad) using binocular observation and histological analysis. We found medullary bone in two femora from the Oranda–shokan–ato site (1650–1850 ad). The results indicate that the two femora were from domestic geese. By using secondary bone as an indicator of the domesticity of geese, knowledge regarding the origins of domestic geese can be expanded, and the morphological and/or genetic changes, as well as the domestication process, can be revealed. According to the literature, domestic geese were kept in Japan from the early eight century ad and were popular after the 17th century ad. The scarcity of medullary bone in the samples can be explained by the small number of domestic geese in Japan and/or by butchering practices that excluded the eating of breeding female geese. Copyright © 2013 John Wiley & Sons, Ltd.
- Published
- 2013
186. γ″-Ni3Nb precipitate in Fe–Ni base alloy
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Tsunemitsu Yoshitake, Naoko Oono, Shigeharu Ukai, Shinichiro Yamashita, T. Inoue, Keisuke Sano, and Shigenari Hayashi
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chemistry.chemical_classification ,Nuclear and High Energy Physics ,Materials science ,Base (chemistry) ,Alloy ,Metallurgy ,engineering.material ,Nuclear Energy and Engineering ,chemistry ,Metastability ,engineering ,General Materials Science ,Dislocation ,Chemical composition - Abstract
For Fe–Ni alloy involving the metastable γ″-Ni3Nb precipitates in the standard chemical composition of Fe–43Ni–15Cr–2W–1Mo–3.8Nb–0.1V–0.1Ti–0.28Al–0.1Zr–0.04C (mass%), hardness measurement and TEM analyses were performed during aging at temperatures 650–750 °C up to 200 h after 20% cold-rolling. The hardness increases due to coherent γ″-Ni3Nb precipitate, but longer aging induces hardness decrease due to its coarsening and dislocation recovery. Aging at 800 °C for 200 h leads to transformation to the stable δ-Ni3Nb. Based on these data, an appropriate aging condition is considered to be at the temperature 700–750 °C for 8 h in order to distribute finely intra-granular γ″ precipitates at the final stage of manufacturing.
- Published
- 2013
187. P1.12-008 Photodynamic Therapy for Peripheral Lung Cancers Using Composite-Type Optical Fiberscope of 1.0 mm in Diameter
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J. Usuda, T. Inoue, and K. Takegahara
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Pulmonary and Respiratory Medicine ,Oncology - Published
- 2017
188. Case ReportA case of asynchronous bilateral cancer of the oral commissure
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T, Imaizumi, primary, M, Ooishi, additional, H, Irie, additional, T, Inoue, additional, Y, Narisawa, additional, and Y, Yamaguchi, additional
- Published
- 2018
- Full Text
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189. Combination of KAATSU training® and BCAA intake for a patient after aortic valve replacement surgery
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A, Ooshima, primary, S, Katayanagi, additional, C, Arakawa, additional, R, Takahashi, additional, N, Nozawa, additional, Y, Mizushima, additional, K, Matsumoto, additional, T, Sawaguchi, additional, A, Haruyama, additional, S, Toyoda, additional, H, Ogawa, additional, I, Shibasaki, additional, H, Yagi, additional, S, Yamaguchi, additional, A, Uematsu, additional, T, Yasuda, additional, Y, Sato, additional, H, Fukuda, additional, T, Inoue, additional, and T, Nakajima, additional
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- 2018
- Full Text
- View/download PDF
190. IgG/IgA pemphigus representing pemphigus vegetans caused by low titres of IgG and IgA antibodies to desmoglein 3 and IgA antibodies to desmocollin 3
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R Ikegami, N Mizoguchi, Norito Ishii, Takaaki Hanafusa, Takashi Hashimoto, T Inoue-Nishimoto, A Hirohata, S Sakamoto, E Mabuchi-Kiyohara, and K Matsumoto
- Subjects
Male ,Immunoglobulin A ,Dermatology ,Desmocollins ,Immunoglobulin G ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,IgA pemphigus ,education ,education.field_of_study ,Desmoglein 3 ,biology ,business.industry ,Middle Aged ,medicine.disease ,Infectious Diseases ,030220 oncology & carcinogenesis ,Immunology ,biology.protein ,Desmocollin ,Antibody ,Pemphigus vegetans ,business - Published
- 2015
191. Modeling grade progression in an active surveillance study
- Author
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Alan W. Partin, Lurdes Y. T. Inoue, H.B. Carter, Bruce J. Trock, and Ruth Etzioni
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Male ,Statistics and Probability ,Oncology ,medicine.medical_specialty ,Epidemiology ,Biopsy ,medicine.medical_treatment ,Disease ,Biostatistics ,Models, Biological ,Cohort Studies ,Prostate cancer ,Internal medicine ,medicine ,Humans ,Computer Simulation ,Watchful Waiting ,Prostatectomy ,Likelihood Functions ,Models, Statistical ,medicine.diagnostic_test ,business.industry ,Prostatic Neoplasms ,Bayes Theorem ,Cell Dedifferentiation ,medicine.disease ,Surgery ,Cohort ,Disease Progression ,Neoplasm Grading ,business ,Watchful waiting ,Cohort study - Abstract
Prostate cancer grade, assessed with the Gleason score, describes how abnormal the tumor tissue and cells appear, and it is an important prognostic indicator of disease progression. Whether prostate tumors change grade is a question that has implications for screening and treatment. Empirical data on tumor grade over time have become available from men biopsied regularly as part of active surveillance (AS). However, biopsy (BX) grade is subject to misclassification. In this article, we develop a model that allows for estimation of the time of grade change while accounting for the misclassification error from BX grade. We use misclassification rates from studies of prostate cancer BXs followed by radical prostatectomy. Estimation of the transition times from true low-grade to high-grade disease is conducted within a Bayesian framework. We apply our model to serial observations on BX grade among 627 cases enrolled in a cohort of AS patients at Johns Hopkins University who were biopsied annually and referred to treatment if there was any evidence of disease progression on BX. We consider different prior distributions for the time to true grade progression. The estimated likelihood of grade progression within 10 years of study entry ranges from 12% to 24% depending on the prior. We conclude that knowledge of rates of grade misclassification allows for determination of true grade progression rates among men with serial BXs on AS. Although our results are sensitive to prior specifications, they indicate that in a nontrivial fraction of the patient population, tumor grade can progress. Copyright © 2013 John Wiley & Sons, Ltd.
- Published
- 2013
192. Overview of KSTAR Results in Phase-I Operation
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Wonho Choe, Ken Kajiwara, S. H. Joung, T. T. Hoang, A.W. Hyatt, Y.M. Park, L. R. Grisham, Yong-Seok Hwang, Hyeon K. Park, Joon-Wook Ahn, T. Inoue, H. K. Kim, Y. S. Bae, S. R. In, John Lohr, J.C. Hosea, J. G. Park, M. Kwon, Kaprai Park, Moo-Hyun Cho, J.A. Leuer, W.C. Kim, Y. S. Park, M.K. Park, Won Namkung, S.A. Sabbagh, Keishi Sakamoto, Jik-Soo Kim, Jong-Gu Kwak, Y. Chu, Jong-Su Kim, Sang-Gu Lee, Lena Delpech, Y. K. Oh, R. Ellis, N.W. Eidietis, Yong-Su Na, H. L. Yang, X. Litaudon, Kazuyoshi Watanabe, M.L. Walker, Y.A. Gorelov, D. Mueller, Yasuhisa Oda, and Kstar Team
- Subjects
Physics ,Nuclear and High Energy Physics ,Tokamak ,Mechanical Engineering ,Nuclear engineering ,Phase (waves) ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Superconducting tokamak ,Nuclear Energy and Engineering ,law ,KSTAR ,0103 physical sciences ,General Materials Science ,010306 general physics ,Civil and Structural Engineering - Abstract
The KSTAR (Korea Superconducting Tokamak Advanced Researc pursued to develop key technologies for superconducting tokamak operation and to contribute to a few research items for ITER relevant issue...
- Published
- 2013
193. Survival benefit of primary prevention implantable cardioverter-defibrillator therapy after myocardial infarction: Does time to implant matter? A meta-analysis using patient-level data from 4 clinical trials
- Author
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Alan H. Kadish, Gillian D Sanders, Alfred E. Buxton, J. Thomas Bigger, Amy Laird, William J. Hall, Riccardo Cappato, Daniel B. Mark, Gust H. Bardy, Lurdes Y. T. Inoue, Rex Edwards, Jonathan P. Piccini, Paul Dorian, Al Hallstrom, Peter J. Kudenchuk, Arthur J. Moss, Paul L. Hess, Sana M. Al-Khatib, Richard C. Steinman, and Kerry L. Lee
- Subjects
medicine.medical_specialty ,business.industry ,Proportional hazards model ,medicine.medical_treatment ,Hazard ratio ,Implantable cardioverter-defibrillator ,medicine.disease ,Clinical trial ,Physiology (medical) ,Internal medicine ,Conventional PCI ,medicine ,Cardiology ,Myocardial infarction complications ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,business ,Multicenter Automatic Defibrillator Implantation Trial - Abstract
Background Whether there is an optimal time to place an implantable cardioverter-defibrillator (ICD) more than 40 days after myocardial infarction (MI) in guideline-eligible patients is unknown. Objective To evaluate the effect of time from MI to randomization on mortality, rehospitalizations, and complications. Methods Individual data on patients enrolled in 9 primary prevention ICD trials were provided. Clinical trials were eligible for the current analysis if they enrolled patients with an MI more than 40 days prior to randomization to primary prevention ICD therapy vs usual care: Multicenter Automatic Defibrillator Implantation Trial I, Multicenter UnSustained Tachyardia Trial, Multicenter Automatic Defibrillator Implantation Trial II, and Sudden Cardiac Death in Heart Failure Trial. Results ICD recipients died less frequently than nonrecipients at 5 years across all subgroups of time from MI to randomization. In unadjusted Cox proportional hazards regression, a survival benefit was evident in most subgroups. Adjusted Bayesian Weibull survival modeling yielded hazard ratio (HR) 0.50, 95% posterior credible interval (PCI) 0.20–1.25 41–180 days after MI; HR 0.98, 95% PCI 0.37–2.37 181–365 days after MI; HR 0.22, 95% PCI 0.07–0.59>1–2 years after MI; HR 0.42, 95% PCI 0.17–0.90>2–5 years after MI; HR 0.55, 95% PCI 0.25–1.15>5–10 years after MI; and HR 0.48, 95% PCI 0.20–1.02>10 years after MI. There was no evidence of an interaction between time from MI and all-cause mortality, rehospitalizations, or complications. Conclusions In this meta-analysis, there was scant evidence that the efficacy of primary prevention ICD therapy depends on time to implantation more than 40 days after MI. Similarly, there was no evidence that the risks of rehospitalizations or complications depend on time more than 40 days after MI.
- Published
- 2013
194. Magnetic properties of siliceous marine sediments in Northern Hokkaido, Japan: a quantitative tectono-sedimentological study of basins along an active margin
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S. Kusumoto, T. Inoue, and Y. Itoh
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Paleontology ,geography ,Sinistral and dextral ,geography.geographical_feature_category ,Geology ,Sedimentary rock ,Fault (geology) ,Sedimentary basin ,Structural basin ,Neogene ,Structural geology ,Rock magnetism - Abstract
The formation processes of the late Neogene sedimentary basins in Northern Hokkaido have been investigated on the basis of rock magnetism, structural geology and numerical modelling. Untilted site-mean directions of remanent magnetization of the Wakkanai Formation, obtained from oriented core samples in Horonobe, suggest remarkable counterclockwise block rotation (ca. 70°) since the late Neogene. Uniform microscopic fabric of the siliceous sediments was inferred from the alignment of the principal axes of the anisotropy of magnetic susceptibility (AMS). After correction for tectonic rotation, the maximum axis of AMS, which reflects the sedimentary fabric of the dominant paramagnetic minerals, is in an E-W direction, which is concordant with the influx direction of diatomaceous particles into the N-S elongate sedimentary basins. The difference in the bulk initial magnetic susceptibility of the siliceous sediments of the Wakkanai Formation between the depocenter of the basin and its peripheral part implies that terrigenous non-magnetic fraction has been sorted out during transportation of the detrital grains as gravity flows. As for the development mechanism of the N-S elongate late Neogene basins in Northern Hokkaido, their depocenter arrangement and subsidence pattern indicates dextral motions upon a longitudinal fault zone along the Eurasian convergent margin. Dislocation modelling was adopted to explain vertical displacement and rotational motion around the study area and successfully restored the deformation pattern based on the assumption of dextral slip at a left-stepping part of a strand of the transcurrent fault.
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- 2013
195. K ->2 Decay in the Nambu-Jona-Lasinio Model
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M. Takizawa, T. Inoue, and M. Oka
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Physics and Astronomy (miscellaneous) - Published
- 2013
196. Weak Hyperon-Nucleon Interaction in a Quark Model and Application to the pn -> p Scattering
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T. Inoue, K. Sasaki, S. Takeuchi, and M. Oka
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Physics and Astronomy (miscellaneous) - Published
- 2013
197. Pathophysiology and clinical studies in CKD 5D
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J. G. Raimann, F. Gotch, M. Keen, P. Kotanko, N. W. Levin, A. Pierratos, R. Lindsay, G. Severova-Andreevska, L. Trajceska, S. Gelev, G. Selim, A. Sikole, S. Y. Yoon, S. D. Hwang, D. K. Cho, Y. H. Cho, S. J. Moon, W. Ribitsch, P. J. Schreiner, M. Uhlmann, G. Schilcher, V. Stadlbauer, J. H. Horina, A. R. Rosenkranz, D. Schneditz, I. Kiss, L. Kerkovits, C. Ambrus, I. Kulcsar, J. Szegedi, A. Benke, B. Borbas, S. Ferenczi, M. Hengsperger, S. Kazup, L. Nagy, J. Nemeth, A. Rozinka, T. Szabo, T. Szelestei, E. Toth, G. Varga, G. Wagner, G. Zakar, L. Gergely, A. Tisler, Z. Kiss, S. Sasaki, M. Miyamato, A. Nomura, K. Koitabashi, H. Nishiwaki, T. Suzuki, D. Uchida, H. Kawarazaki, Y. Shibagaki, K. Kimura, C. Libetta, C. Martinelli, E. Margiotta, I. Borettaz, M. Canevari, P. Esposito, V. Sepe, A. Dal Canton, P. Pateinakis, C. Dimitriadis, A. Papagianni, S. Douma, G. Efstratiadis, D. Memmos, C. L. Nelson, P. J. Dunstan, R. Zwiech, Y. Hasuike, K. Yanase, S. Hamahata, T. Nagai, M. Yahiro, S. Kaibe, A. Kida, Y. Nagasawa, T. Kuragano, T. Nakanishi, J. S. Kim, J. W. Yang, S. O. Choi, B. G. Han, J. H. Chang, A. J. Kim, H. S. Kim, H. Ro, J. Y. Jung, H. H. Lee, W. Chung, H. Tanaka, T. Kita, K. Okamoto, M. Mikami, R. Sakai, E. Lojacono, B. Votta, T. Rampino, M. Gregorini, A. Amore, R. Coppo, M. M. S. ElSharkawy, M. Kamel, M. Elhamamsy, S. Allam, J.-H. Ryu, S. Lee, S. C. Hong, S.-J. Kim, D.-H. Kang, D.-R. Ryu, K. B. Choi, T. Kiraz, A. Yalcin, M. Akay, G. Sahin, A. Musmul, Y. Kamijo, H. Horiuchi, H. Iida, K. Saito, R. Furutera, Y. Ishibashi, M. Sidiropoulou, S. Patsialas, M. Angelopoulos, M. Torreggiani, N. Serpieri, M. Arazzi, V. Esposito, M. Calatroni, E. La Porta, D. Catucci, G. Montagna, L. Semeraro, E. Efficace, V. Piazza, L. Picardi, G. Villa, C. Esposito, J. C. Kim, E. Hwang, K. Park, H. Karakizlis, K. Bohl, B. Kortus-Goetze, R. Dodel, J. Hoyer, A. Cinar, R. Kazancioglu, A. T. Isik, E. Aydemir, B. Gorcin, J. Radic, D. Ljutic, M. Radic, V. Kovacic, M. Sain, K. Dodig Curkovic, A. E. Grzegorzewska, L. Niepolski, J. Sikora, P. Jagodzinski, A. Sowinska, V. Sirolli, C. Rossi, A. Di Castelnuovo, P. Felaco, L. Amoroso, M. Zucchelli, D. Ciavardelli, P. Sacchetta, A. Urbani, A. Arduini, M. Bonomini, T. Inoue, K. Okano, Y. Tsuruta, K. Tsuchiya, T. Akiba, K. Nitta, and D. Pajzderski
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Transplantation ,Nephrology - Published
- 2013
198. Novel method for the production of spin-aligned RI beams in projectile fragmentation with the dispersion matching technique
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N. Aoi, Hideki Ueno, R. Chevrier, Hiroshi Watanabe, Takeshi Furukawa, Tetsuya Ohnishi, Y. Ishii, Daisuke Kameda, Masato Tsuchiya, G. Georgiev, H. Takeda, H. Iijima, T. Kubo, Tsubasa Nanao, H. Hayashi, N. Inabe, J. M. Daugas, Masayasu Ishihara, Dimiter L. Balabanski, M. Rajabali, T. Inoue, Akihiro Yoshimi, Koichiro Asahi, Yuichi Ichikawa, Naoki Fukuda, K. Suzuki, DAM Île-de-France (DAM/DIF), Direction des Applications Militaires (DAM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), CSNSM SNO, Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), and Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)
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Physics ,Nuclear and High Energy Physics ,Matching (graph theory) ,010308 nuclear & particles physics ,[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex] ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Present method ,Dispersion (optics) ,0103 physical sciences ,Nuclear spin ,Figure of merit ,Physics::Accelerator Physics ,spin-aligned RI beams ,Nuclear moment ,projectile fragment ,Physical and Theoretical Chemistry ,Atomic physics ,Spin (physics) ,010306 general physics ,Nuclear Experiment ,RI beam ,Projectile fragmentation ,Beam (structure) - Abstract
A novel method to produce spin-aligned rare-isotope (RI) beam has been developed, that is the two-step projectile fragmentation method with a technique of dispersion matching. The present method was verified in an experiment at the RIKEN RIBF, where an RI beam of 32Al with spin alignment of 8(1) % was successfully produced from a primary beam of 48Ca, with 33Al as an intermediate nucleus. Figure of merit of the present method was found to be improved by a factor larger than 50 compared with a conventional method employing single-step projectile fragmentation. ispartof: pages:47-51 ispartof: Hyperfine Interactions vol:220 issue:1 pages:47-51 ispartof: 4th Joint International Conference on Hyperfine Interactions / International Symposium on Nuclear Quadrupole Interactions (HFI/NQI) location:Beijing, China date:10 Sep - 14 Sep 2012 status: published
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- 2013
199. Dynamic Analysis of Motion of Crawler-Type Remotely Operated Vehicles
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T. Shiosawa, T. Inoue, and K. Takagi
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Engineering ,Buoyancy ,business.industry ,Mechanical Engineering ,Ocean Engineering ,Terrain ,engineering.material ,Remotely operated underwater vehicle ,Climbing ,Electrical and Electronic Engineering ,Underwater ,business ,Web crawler ,Slip (vehicle dynamics) ,Marine engineering ,Added mass - Abstract
A crawler system has the potential to expand research and development on seafloors with irregular steep terrain and sand. Characteristic parameters in water, such as added mass, buoyancy, and hydrodynamic forces, considerably affect and decrease the mobility of crawler-type remotely operated vehicles (ROVs). To study and evaluate the mobile performance of a crawler system, it is important to investigate the dynamic motion of the crawler system by considering these effects. This paper presents a mathematical model of an underwater crawler system to show the dynamic effects on the vehicle's motion; experiments were conducted on a crawler-type ROV climbing over a bump in a water tank to examine the slip characteristics at sea. The simulated results agreed well with the experimental results. The mathematical model presented in this paper simulates the dynamic motion for climbing over a bump and the slip characteristics very well, and it reveals the physics of the crawler-type ROV's motion. The proposed mathematical model is useful for dynamic analysis.
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- 2013
200. The effect of phosphatidylserine administration on memory and symptoms of attention‐deficit hyperactivity disorder: a randomised, double‐blind, placebo‐controlled clinical trial
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S. Hirayama, R. Jäger, Roland Rabeler, M. Purpura, T. Hirayama, Y. Tatsumi, K. Terasawa, and T. Inoue
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Male ,medicine.medical_specialty ,Echoic memory ,Adolescent ,Medicine (miscellaneous) ,Phosphatidylserines ,Impulsivity ,Placebo ,Double-Blind Method ,Memory ,Internal medicine ,medicine ,Memory span ,Humans ,Attention deficit hyperactivity disorder ,Child ,Psychiatry ,Wechsler Intelligence Scale for Children ,Nutrition and Dietetics ,Working memory ,business.industry ,medicine.disease ,Treatment Outcome ,Attention Deficit Disorder with Hyperactivity ,Child, Preschool ,Go/no go ,Dietary Supplements ,Female ,medicine.symptom ,business - Abstract
Background Attention-deficit hyperactivity disorder (ADHD) is the most commonly diagnosed behavioural disorder of childhood, affecting 3–5% of school-age children. The present study investigated whether the supplementation of soy-derived phosphatidylserine (PS), a naturally occurring phospholipid, improves ADHD symptoms in children. Methods Thirty six children, aged 4–14 years, who had not previously received any drug treatment related to ADHD, received placebo (n = 17) or 200 mg day–1 PS (n = 19) for 2 months in a randomised, double-blind manner. Main outcome measures included: (i) ADHD symptoms based on DSM-IV-TR; (ii) short-term auditory memory and working memory using the Digit Span Test of the Wechsler Intelligence Scale for Children; and (iii) mental performance to visual stimuli (GO/NO GO task). Results PS supplementation resulted in significant improvements in: (i) ADHD (P
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- 2013
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