Search

Your search keyword '"Sun, Linlin"' showing total 1,709 results
Start Over Author "Sun, Linlin"
1,709 results on '"Sun, Linlin"'

151. Multifunctionality matters: preverbal <italic>yǒu</italic> in Mandarin and its aspectual potential.

Author

Sun, Linlin and Bisang, Walter

Subjects
*NATIVE language, *GRAMMATICALIZATION, *MORPHEMICS, *LANGUAGE & languages, *QUESTIONNAIRES
Abstract

This article confronts a multifunctional grammaticalized form in Mandarin, the preverbal morpheme yǒu (有). Since its appearance in the Chinese mainland around the 1990s, there has been controversy about whether it is an aspect marker or not. In response to this question, we conducted a questionnaire survey to investigate how native Mandarin speakers generally understand sentences with preverbal yǒu. The results not only show that preverbal yǒu can serve as a perfective viewpoint marker that makes the terminal boundary of an event semantically visible, but also provide evidence of its other function as an existential marker. The concrete function of preverbal yǒu (perfective or existential) depends on pragmatic inference based on the temporal properties of a given situation. With this observation, the paper resolves the controversy of which of these two functions actually applies to preverbal yǒu, and integrates this marker into the broader context of pragmatics-based multifunctionality as it is widely found in Sinitic and mainland Southeast Asian languages. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

153. Differences and Mechanism of Waxy Corn Starch and Normal Corn Starch in the Preparation of Recrystallized Resistant Starch (RS3).

Author

Su, Qing, Chen, Lirong, Sun, Linlin, Liu, Kaichang, and Gong, Kuijie

Subjects
CORNSTARCH, STARCH, DEGREE of polymerization, MOLECULAR structure, AMYLOSE
Abstract

This study prepared resistant starch (RS) from waxy corn starch and normal corn starch and analyzed the effects of its molecular and microstructural characteristics on RS content. The RS content of waxy corn resistant starch (RS-WCS) was highest at 57.8%, whereas that of normal corn resistant starch (RS-NCS) was 41.46%. The short-chain amylose contents of RS-WCS and RS-NCS were 47.08% and 37.24%, respectively, proportional to their RS content. Additionally, RS content positively correlated with crystallinity, short-range order degree, and degree of polymerization (DP), exceeding 25. Electron microscopic images, before and after enzymolysis, revealed that RS-WCS was hydrolyzed from the surface to the center by pancreatic α-amylase, while RS-NCS underwent simultaneous hydrolysis at the surface and center. These results indicate that the higher RS content in RS-WCS, compared to RS-NCS, is attributable to the synergistic effects of molecular structure and microstructure. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

154. PKMYT1 knockdown inhibits cholesterol biosynthesis and promotes the drug sensitivity of triple-negative breast cancer cells to atorvastatin.

Author

Gao, Wei, Guo, Xin, Sun, Linlin, Gai, Jinwei, Cao, Yinan, and Zhang, Shuqun

Subjects
STEROL regulatory element-binding proteins, TRIPLE-negative breast cancer, METABOLIC reprogramming, CANCER cell proliferation, LIPID metabolism
Abstract

Triple negative breast cancer (TNBC) as the most aggressive molecular subtype of breast cancer is characterized by high cancer cell proliferation and poor patient prognosis. Abnormal lipid metabolism contributes to the malignant process of cancers. Study observed significantly enhanced cholesterol biosynthesis in TNBC. However, the mechanisms underlying the abnormal increase of cholesterol biosynthesis in TNBC are still unclear. Hence, we identified a member of the serine/threonine protein kinase family PKMYT1 as a key driver of cholesterol synthesis in TNBC cells. Aberrantly high-expressed PKMYT1 in TNBC was indicative of unfavorable prognostic outcomes. In addition, PKMYT1 promoted sterol regulatory element-binding protein 2 (SREBP2)-mediated expression of enzymes related to cholesterol biosynthesis through activating the TNF/ TNF receptor-associated factor 1 (TRAF1)/AKT pathway. Notably, downregulation of PKMYT1 significantly inhibited the feedback upregulation of statin-mediated cholesterol biosynthesis, whereas knockdown of PKMYT1 promoted the drug sensitivity of atorvastatin in TNBC cells. Overall, our study revealed a novel function of PKMYT1 in TNBC cholesterol biosynthesis, providing a new target for targeting tumor metabolic reprogramming in the cancer. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

180. Biomedical Applications of Functional Micro-/Nanoimaging Probes

Author

Yu, Fangfang, Xu, Shunlong, Ni, Xianwei, Ye, Jinmin, Cheng, Yueyue, Wang, Pengfei, Wu, Beibei, Wang, Chengfang, Dong, Yanyan, Wang, Liping, He, Chunchun, Yang, Yan, Zou, Chunpeng, Liu, Xiangjun, Shangguan, Dihua, Gao, Ming, Sun, Linlin, Webster, Thomas J., Liu, Zhe, and Liu, Zhe, editor

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results