791 results on '"Strati P"'
Search Results
152. P1129: ACALABRUTINIB IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) MARGINAL ZONE LYMPHOMA (MZL): RESULTS OF A PHASE 2, MULTICENTER, OPEN-LABEL TRIAL
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P. Strati, M. Coleman, D. Stevens, S. Ma, C. Patti, M. Levy, I. S. Lossos, P. Ramakrishnan Geethakumari, S. Lam, R. Calvo, K. Higgins, and L. Budde
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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153. P1222: PACIFIC: BRENTUXIMAB VEDOTIN AND NIVOLUMAB ALONE AND THEN COMBINED WITH RITUXIMAB, CYCLOPHOSPHAMIDE, DOXORUBICIN AND PREDNISONE FOR UNTREATED PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA PATIENTS
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R. Steiner, P. Strati, C. Flowers, S. Neelapu, M. Green, L. Nastoupil, F. Hagemeister, L. Feng, S. Ahmed, R. Nair, L. Fayad, H. Lee, M. A. Rodriguez, and J. Westin
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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154. Measuring Engagement as Students Learn Dynamic Systems and Control with a Video Game
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Coller, B. D., Shernoff, David J., and Strati, Anna
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The paper presents results of a multi-year quasi-experimental study of student engagement during which a video game was introduced into an undergraduate dynamic systems and control course. The video game, "EduTorcs", provided challenges in which students devised control algorithms that drive virtual cars and ride virtual bikes through a simulated game environment. Engagement was conceptualized through the theoretical framework of flow and measured with a technique called the Experience Sampling Method. The study compared engagement and other experiential measures in the last year before the game was introduced and in the year in which the game was fully implemented for the first time. Furthermore, the investigation made attempts to find connections between in-the-moment engagement and characteristics of students and situational factors. Finally, the study compared enrollment rates into an advanced level dynamic systems and control course across years, comparing the percentage of students taking the game-based course who chose to pursue the subject further to that of students who took the course without the game.
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- 2011
155. Second Cancers and Richter Transformation Are the Leading Causes of Death in Patients With Trisomy 12 Chronic Lymphocytic Leukemia
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Strati, Paolo, Abruzzo, Lynne V, Wierda, William G, O'Brien, Susan, Ferrajoli, Alessandra, and Keating, Michael J
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Oncology and Carcinogenesis ,Genetics ,Cancer ,Prevention ,Hematology ,Rare Diseases ,Clinical Research ,ADP-ribosyl Cyclase 1 ,Aged ,Aged ,80 and over ,Cause of Death ,Chromosomes ,Human ,Pair 12 ,Female ,Humans ,In Situ Hybridization ,Fluorescence ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Lymphoma ,Large B-Cell ,Diffuse ,Male ,Membrane Glycoproteins ,Neoplasms ,Second Primary ,Retrospective Studies ,Thrombocytopenia ,Trisomy ,CLL ,Prognosis ,Richter transformation ,Second cancers ,Trisomy 12 ,Clinical Sciences ,Cardiovascular medicine and haematology ,Oncology and carcinogenesis - Abstract
BackgroundTrisomy 12 (+12) is detected by fluorescence in-situ hybridization (FISH) analysis in up to 20% of patients with chronic lymphocytic leukemia (CLL). Patients with +12 are known to have unique features and to carry an intermediate prognosis.Patients and methodsIn order to better define this large group, we reviewed the characteristics of 250 untreated patients with +12.ResultsWhen compared to 516 untreated patients negative for +12 by FISH, patients with +12 showed a higher incidence of thrombocytopenia, Richter transformation, and second malignant neoplasms (SMN), in addition to the expected increased rate of CD38 positivity and atypical immunophenotype. At a median follow-up of 51 months, 57% of patients needed first-line treatment; median time to first treatment was 38 months, and on multivariate analysis (MVA), it was found to be shorter in patients with advanced Rai stage, palpable splenomegaly, and deletion of 14q by conventional cytogenetic analysis. The overall response rate with first-line treatment was 94%. The median failure-free survival has not been reached, but on MVA, it was found to be shorter in patients whose disease responded in a manner other than complete remission or with FISH negativity for deletion 13q. The median overall survival for the entire group has not been reached, but MVA revealed it to be shorter in patients with an absolute lymphocyte count of > 30 × 10(9)/L or who developed SMN. Eighteen deaths have been observed so far, and Richter transformation and SMN were the leading causes of death (3 and 6, respectively).ConclusionPatients with +12 CLL show characteristic clinical and biologic features, and may benefit from increased surveillance for second cancers.
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- 2015
156. Outcome of patients with low‐risk and intermediate‐1‐risk myelodysplastic syndrome after hypomethylating agent failure: A report on behalf of the MDS Clinical Research Consortium
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Jabbour, Elias J, Garcia‐Manero, Guillermo, Strati, Paolo, Mishra, Asmita, Ali, Najla H Al, Padron, Eric, Lancet, Jeffrey, Kadia, Tapan, Daver, Naval, O'Brien, Susan, Steensma, David P, Sekeres, Mikkael A, Gore, Steven D, Dezern, Amy, Roboz, Gail J, List, Alan F, Kantarjian, Hagop M, and Komrokji, Rami S
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Hematology ,Cancer ,Rare Diseases ,Prevention ,Adult ,Aged ,Aged ,80 and over ,Antimetabolites ,Antineoplastic ,Disease Progression ,Disease-Free Survival ,Female ,Humans ,Male ,Middle Aged ,Myelodysplastic Syndromes ,Prognosis ,Retrospective Studies ,Risk Factors ,Treatment Outcome ,Young Adult ,hypomethylating agent failure ,low-risk ,myelodysplastic syndrome ,survival ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Public health - Abstract
BackgroundThe hypomethylating agents (HMAs) azacitidine and decitabine are most commonly used to treat patients with higher-risk myelodysplastic syndromes (MDS). To the authors' knowledge, the prognosis of patients with low-risk and intermediate-1-risk MDS by the International Prognostic Scoring System (IPSS) after HMA failure has not been explored comprehensively.MethodsThe clinical characteristics and treatment outcome of 438 patients with low-risk and intermediate-1-risk MDS who were treated with HMAs were retrospectively analyzed.ResultsUsing the International Working Group response criteria, the overall objective response to HMA was 35% with a median of 6 cycles of HMA administered, and the median response duration was 7 months. Only 7% of patients had disease that transformed into acute myeloid leukemia while receiving therapy. Of the 290 patients who were evaluable at the time of HMA failure, 77% remained in the lower-risk disease categories. On multivariate analysis, baseline neutropenia, intermediate-risk and poor-risk baseline karyotype, and lack of response to HMA were found to be independently associated with a higher risk of disease progression. With a median follow-up of 16 months, the median transformation-free survival and overall survival (OS) after HMA failure were 15 months and 17 months, respectively. On multivariate analysis, only The University of Texas MD Anderson Global Scoring System was found to be independently predictive of outcome, with patients with higher-risk categories having poor transformation-free survival (hazards ratio [HR], 1.5; P = .003) and OS (HR, 1.8; P = .002). The administration of salvage therapy was independently associated with better OS only (HR, 0.8; P = .01).ConclusionsOutcomes of patients with lower-risk MDS after HMA failure are poor and the treatment of these patients remains an unmet medical need. OS is a reasonable primary endpoint for clinical studies targeting this population.
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- 2015
157. A multivariate spatial interpolation of airborne {\gamma}-ray data using the geological constraints
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Guastaldi, E., Baldoncini, M., Bezzon, G. P., Broggini, C., Buso, G. P., Caciolli, A., L., Carmignani, Callegari, I., Colonna, T., Dule, K., Fiorentini, G., Xhixha, M. Kaçeli, Mantovani, F., Massa, G., Menegazzo, R., Mou, L., Alvarez, C. Rossi, Strati, V., Xhixha, G., and Zanon, A.
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Physics - Geophysics - Abstract
In this paper we present maps of K, eU, and eTh abundances of Elba Island (Italy) obtained with a multivariate spatial interpolation of airborne {\gamma}-ray data using the constraints of the geologic map. The radiometric measurements were performed by a module of four NaI(Tl) crystals of 16 L mounted on an autogyro. We applied the collocated cokriging (CCoK) as a multivariate estimation method for interpolating the primary under-sampled airborne {\gamma}-ray data considering the well-sampled geological information as ancillary variables. A random number has been assigned to each of 73 geological formations identified in the geological map at scale 1:10,000. The non-dependency of the estimated results from the random numbering process has been tested for three distinct models. The experimental cross-semivariograms constructed for radioelement-geology couples show well-defined co-variability structures for both direct and crossed variograms. The high statistical correlations among K, eU, and eTh measurements are confirmed also by the same maximum distance of spatial autocorrelation. Combining the smoothing effects of probabilistic interpolator and the abrupt discontinuities of the geological map, the results show a distinct correlation between the geological formation and radioactivity content. The contour of Mt. Capanne pluton can be distinguished by high K, eU and eTh abundances, while different degrees of radioactivity content identify the tectonic units. A clear anomaly of high K content in the Mt. Calamita promontory confirms the presence of felsic dykes and hydrothermal veins not reported in our geological map. Although we assign a unique number to each geological formation, the method shows that the internal variability of the radiometric data is not biased by the multivariate interpolation., Comment: 43 pages, 9 figures, 5 tables. In Remote Sensing of Environment (2013)
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- 2013
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158. Predicting Kindergarteners' Achievement and Motivation from Observational Measures of Teaching Effectiveness
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Mantzicopoulos, Panayota, Patrick, Helen, Strati, Anna, and Watson, Jesse S.
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We investigated the premise that observation measures of instruction are indicators of effective teaching, using the definition of effectiveness articulated by departments of education: teaching that boosts student achievement. We argued that student motivation is equally as important as achievement in the evaluation of teaching effectiveness (TE); therefore, we examined students' (N = 145) achievement and motivation outcomes. We scored 40 lessons (from 10 kindergarten teachers) with two TE observation measures: the content-independent Classroom Assessment Scoring System (CLASS) and the content-specific Reformed Teaching Observation Protocol (RTOP). We found that the two measures' scores were related differently to student outcomes. Instructionally supportive practices (CLASS and RTOP total) predicted achievement and motivation. Emotional support (CLASS) was positively related to motivation but not to achievement. Classroom organization (CLASS) was negatively related to both motivation and achievement. The CLASS total score did not predict student outcomes; its use masked differences across domains of teaching practices.
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- 2018
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159. JUNO sensitivity to low energy atmospheric neutrino spectra
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Abusleme, Angel, Adam, Thomas, Ahmad, Shakeel, Ahmed, Rizwan, Aiello, Sebastiano, Akram, Muhammad, An, Fengpeng, An, Guangpeng, An, Qi, Andronico, Giuseppe, Anfimov, Nikolay, Antonelli, Vito, Antoshkina, Tatiana, Asavapibhop, Burin, de André, João Pedro Athayde Marcondes, Auguste, Didier, Babic, Andrej, Baldini, Wander, Barresi, Andrea, Baussan, Eric, Bellato, Marco, Bergnoli, Antonio, Bernieri, Enrico, Birkenfeld, Thilo, Blin, Sylvie, Blum, David, Blyth, Simon, Bolshakova, Anastasia, Bongrand, Mathieu, Bordereau, Clément, Breton, Dominique, Brigatti, Augusto, Brugnera, Riccardo, Bruno, Riccardo, Budano, Antonio, Buscemi, Mario, Busto, Jose, Butorov, Ilya, Cabrera, Anatael, Cai, Hao, Cai, Xiao, Cai, Yanke, Cai, Zhiyan, Cammi, Antonio, Campeny, Agustin, Cao, Chuanya, Cao, Guofu, Cao, Jun, Caruso, Rossella, Cerna, Cédric, Chang, Jinfan, Chang, Yun, Chen, Pingping, Chen, Po-An, Chen, Shaomin, Chen, Xurong, Chen, Yi-Wen, Chen, Yixue, Chen, Yu, Chen, Zhang, Cheng, Jie, Cheng, Yaping, Chetverikov, Alexey, Chiesa, Davide, Chimenti, Pietro, Chukanov, Artem, Claverie, Gérard, Clementi, Catia, Clerbaux, Barbara, Lorenzo, Selma Conforti Di, Corti, Daniele, Costa, Salvatore, Corso, Flavio Dal, Dalager, Olivia, De La Taille, Christophe, Deng, Jiawei, Deng, Zhi, Deng, Ziyan, Depnering, Wilfried, Diaz, Marco, Ding, Xuefeng, Ding, Yayun, Dirgantara, Bayu, Dmitrievsky, Sergey, Dohnal, Tadeas, Dolzhikov, Dmitry, Donchenko, Georgy, Dong, Jianmeng, Doroshkevich, Evgeny, Dracos, Marcos, Druillole, Frédéric, Du, Shuxian, Dusini, Stefano, Dvorak, Martin, Enqvist, Timo, Enzmann, Heike, Fabbri, Andrea, Fajt, Lukas, Fan, Donghua, Fan, Lei, Fang, Can, Fang, Jian, Fang, Wenxing, Fargetta, Marco, Fedoseev, Dmitry, Fekete, Vladko, Feng, Li-Cheng, Feng, Qichun, Ford, Richard, Formozov, Andrey, Fournier, Amélie, Gan, Haonan, Gao, Feng, Garfagnini, Alberto, Genster, Christoph, Giammarchi, Marco, Giaz, Agnese, Giudice, Nunzio, Gonchar, Maxim, Gong, Guanghua, Gong, Hui, Gorchakov, Oleg, Gornushkin, Yuri, Göttel, Alexandre, Grassi, Marco, Grewing, Christian, Gromov, Vasily, Gu, Minghao, Gu, Xiaofei, Gu, Yu, Guan, Mengyun, Guardone, Nunzio, Gul, Maria, Guo, Cong, Guo, Jingyuan, Guo, Wanlei, Guo, Xinheng, Guo, Yuhang, Hackspacher, Paul, Hagner, Caren, Han, Ran, Han, Yang, Hassan, Muhammad Sohaib, He, Miao, He, Wei, Heinz, Tobias, Hellmuth, Patrick, Heng, Yuekun, Herrera, Rafael, Hong, Daojin, Hor, YuenKeung, Hou, Shaojing, Hsiung, Yee, Hu, Bei-Zhen, Hu, Hang, Hu, Jianrun, Hu, Jun, Hu, Shouyang, Hu, Tao, Hu, Zhuojun, Huang, Chunhao, Huang, Guihong, Huang, Hanxiong, Huang, Qinhua, Huang, Wenhao, Huang, Xin, Huang, Xingtao, Huang, Yongbo, Hui, Jiaqi, Huo, Lei, Huo, Wenju, Huss, Cédric, Hussain, Safeer, Insolia, Antonio, Ioannisian, Ara, Isocrate, Roberto, Jelmini, Beatrice, Jen, Kuo-Lun, Jeria, Ignacio, Ji, Xiaolu, Ji, Xingzhao, Jia, Huihui, Jia, Junji, Jian, Siyu, Jiang, Di, Jiang, Xiaoshan, Jin, Ruyi, Jing, Xiaoping, Jollet, Cécile, Jungthawan, Sirichok, Kalousis, Leonidas, Kampmann, Philipp, Kang, Li, Karagounis, Michael, Kazarian, Narine, Khan, Waseem, Khosonthongkee, Khanchai, Korablev, Denis, Kouzakov, Konstantin, Krasnoperov, Alexey, Krumshteyn, Zinovy, Kruth, Andre, Kutovskiy, Nikolay, Kuusiniemi, Pasi, Lachenmaier, Tobias, Landini, Cecilia, Leblanc, Sébastien, Lebrin, Victor, Lefevre, Frederic, Lei, Ruiting, Leitner, Rupert, Leung, Jason, Li, Demin, Li, Fei, Li, Fule, Li, Haitao, Li, Huiling, Li, Jiaqi, Li, Mengzhao, Li, Min, Li, Nan, Li, Nan, Li, Qingjiang, Li, Ruhui, Li, Shanfeng, Li, Tao, Li, Weidong, Li, Weiguo, Li, Xiaomei, Li, Xiaonan, Li, Xinglong, Li, Yi, Li, Yufeng, Li, Zhaohan, Li, Zhibing, Li, Ziyuan, Liang, Hao, Liang, Hao, Liang, Jingjing, Liebau, Daniel, Limphirat, Ayut, Limpijumnong, Sukit, Lin, Guey-Lin, Lin, Shengxin, Lin, Tao, Ling, Jiajie, Lippi, Ivano, Liu, Fang, Liu, Haidong, Liu, Hongbang, Liu, Hongjuan, Liu, Hongtao, Liu, Hui, Liu, Jianglai, Liu, Jinchang, Liu, Min, Liu, Qian, Liu, Qin, Liu, Runxuan, Liu, Shuangyu, Liu, Shubin, Liu, Shulin, Liu, Xiaowei, Liu, Xiwen, Liu, Yan, Liu, Yunzhe, Lokhov, Alexey, Lombardi, Paolo, Lombardo, Claudio, Loo, Kai, Lu, Chuan, Lu, Haoqi, Lu, Jingbin, Lu, Junguang, Lu, Shuxiang, Lu, Xiaoxu, Lubsandorzhiev, Bayarto, Lubsandorzhiev, Sultim, Ludhova, Livia, Luo, Fengjiao, Luo, Guang, Luo, Pengwei, Luo, Shu, Luo, Wuming, Lyashuk, Vladimir, Ma, Bangzheng, Ma, Qiumei, Ma, Si, Ma, Xiaoyan, Ma, Xubo, Maalmi, Jihane, Malyshkin, Yury, Mantovani, Fabio, Manzali, Francesco, Mao, Xin, Mao, Yajun, Mari, Stefano M., Marini, Filippo, Marium, Sadia, Martellini, Cristina, Martin-Chassard, Gisele, Martini, Agnese, Mayilyan, Davit, Mednieks, Ints, Meng, Yue, Meregaglia, Anselmo, Meroni, Emanuela, Meyhöfer, David, Mezzetto, Mauro, Miller, Jonathan, Miramonti, Lino, Monforte, Salvatore, Montini, Paolo, Montuschi, Michele, Müller, Axel, Muralidharan, Pavithra, Nastasi, Massimiliano, Naumov, Dmitry V., Naumova, Elena, Navas-Nicolas, Diana, Nemchenok, Igor, Thi, Minh Thuan Nguyen, Ning, Feipeng, Ning, Zhe, Nunokawa, Hiroshi, Oberauer, Lothar, Ochoa-Ricoux, Juan Pedro, Olshevskiy, Alexander, Orestano, Domizia, Ortica, Fausto, Othegraven, Rainer, Pan, Hsiao-Ru, Paoloni, Alessandro, Parkalian, Nina, Parmeggiano, Sergio, Pei, Yatian, Pelliccia, Nicomede, Peng, Anguo, Peng, Haiping, Perrot, Frédéric, Petitjean, Pierre-Alexandre, Petrucci, Fabrizio, Pilarczyk, Oliver, Rico, Luis Felipe Piñeres, Popov, Artyom, Poussot, Pascal, Pratumwan, Wathan, Previtali, Ezio, Qi, Fazhi, Qi, Ming, Qian, Sen, Qian, Xiaohui, Qian, Zhen, Qiao, Hao, Qin, Zhonghua, Qiu, Shoukang, Rajput, Muhammad Usman, Ranucci, Gioacchino, Raper, Neill, Re, Alessandra, Rebber, Henning, Rebii, Abdel, Ren, Bin, Ren, Jie, Rezinko, Taras, Ricci, Barbara, Robens, Markus, Roche, Mathieu, Rodphai, Narongkiat, Romani, Aldo, Roskovec, Bedřich, Roth, Christian, Ruan, Xiangdong, Ruan, Xichao, Rujirawat, Saroj, Rybnikov, Arseniy, Sadovsky, Andrey, Saggese, Paolo, Salamanna, Giuseppe, Sanfilippo, Simone, Sangka, Anut, Sanguansak, Nuanwan, Sawangwit, Utane, Sawatzki, Julia, Sawy, Fatma, Schever, Michaela, Schuler, Jacky, Schwab, Cédric, Schweizer, Konstantin, Selyunin, Alexandr, Serafini, Andrea, Settanta, Giulio, Settimo, Mariangela, Shao, Zhuang, Sharov, Vladislav, Shaydurova, Arina, Shi, Jingyan, Shi, Yanan, Shutov, Vitaly, Sidorenkov, Andrey, Šimkovic, Fedor, Sirignano, Chiara, Siripak, Jaruchit, Sisti, Monica, Slupecki, Maciej, Smirnov, Mikhail, Smirnov, Oleg, Sogo-Bezerra, Thiago, Sokolov, Sergey, Songwadhana, Julanan, Soonthornthum, Boonrucksar, Sotnikov, Albert, Šrámek, Ondřej, Sreethawong, Warintorn, Stahl, Achim, Stanco, Luca, Stankevich, Konstantin, Štefánik, Dušan, Steiger, Hans, Steinmann, Jochen, Sterr, Tobias, Stock, Matthias Raphael, Strati, Virginia, Studenikin, Alexander, Sun, Gongxing, Sun, Shifeng, Sun, Xilei, Sun, Yongjie, Sun, Yongzhao, Suwonjandee, Narumon, Szelezniak, Michal, Tang, Jian, Tang, Qiang, Tang, Quan, Tang, Xiao, Tietzsch, Alexander, Tkachev, Igor, Tmej, Tomas, Treskov, Konstantin, Triossi, Andrea, Troni, Giancarlo, Trzaska, Wladyslaw, Tuve, Cristina, Ushakov, Nikita, Boom, Johannes van den, Waasen, Stefan van, Vanroyen, Guillaume, Vassilopoulos, Nikolaos, Vedin, Vadim, Verde, Giuseppe, Vialkov, Maxim, Viaud, Benoit, Vollbrecht, Moritz Cornelius, Volpe, Cristina, Vorobel, Vit, Voronin, Dmitriy, Votano, Lucia, Walker, Pablo, Wang, Caishen, Wang, Chung-Hsiang, Wang, En, Wang, Guoli, Wang, Jian, Wang, Jun, Wang, Kunyu, Wang, Lu, Wang, Meifen, Wang, Meng, Wang, Meng, Wang, Ruiguang, Wang, Siguang, Wang, Wei, Wang, Wei, Wang, Wenshuai, Wang, Xi, Wang, Xiangyue, Wang, Yangfu, Wang, Yaoguang, Wang, Yi, Wang, Yi, Wang, Yifang, Wang, Yuanqing, Wang, Yuman, Wang, Zhe, Wang, Zheng, Wang, Zhimin, Wang, Zongyi, Waqas, Muhammad, Watcharangkool, Apimook, Wei, Lianghong, Wei, Wei, Wei, Wenlu, Wei, Yadong, Wen, Liangjian, Wiebusch, Christopher, Wong, Steven Chan-Fai, Wonsak, Bjoern, Wu, Diru, Wu, Fangliang, Wu, Qun, Wu, Wenjie, Wu, Zhi, Wurm, Michael, Wurtz, Jacques, Wysotzki, Christian, Xi, Yufei, Xia, Dongmei, Xie, Yuguang, Xie, Zhangquan, Xing, Zhizhong, Xu, Benda, Xu, Cheng, Xu, Donglian, Xu, Fanrong, Xu, Hangkun, Xu, Jilei, Xu, Jing, Xu, Meihang, Xu, Yin, Xu, Yu, Yan, Baojun, Yan, Taylor, Yan, Wenqi, Yan, Xiongbo, Yan, Yupeng, Yang, Anbo, Yang, Changgen, Yang, Huan, Yang, Jie, Yang, Lei, Yang, Xiaoyu, Yang, Yifan, Yang, Yifan, Yao, Haifeng, Yasin, Zafar, Ye, Jiaxuan, Ye, Mei, Ye, Ziping, Yegin, Ugur, Yermia, Frédéric, Yi, Peihuai, Yin, Na, Yin, Xiangwei, You, Zhengyun, Yu, Boxiang, Yu, Chiye, Yu, Chunxu, Yu, Hongzhao, Yu, Miao, Yu, Xianghui, Yu, Zeyuan, Yu, Zezhong, Yuan, Chengzhuo, Yuan, Ying, Yuan, Zhenxiong, Yuan, Ziyi, Yue, Baobiao, Zafar, Noman, Zambanini, Andre, Zavadskyi, Vitalii, Zeng, Shan, Zeng, Tingxuan, Zeng, Yuda, Zhan, Liang, Zhang, Aiqiang, Zhang, Feiyang, Zhang, Guoqing, Zhang, Haiqiong, Zhang, Honghao, Zhang, Jiawen, Zhang, Jie, Zhang, Jingbo, Zhang, Jinnan, Zhang, Peng, Zhang, Qingmin, Zhang, Shiqi, Zhang, Shu, Zhang, Tao, Zhang, Xiaomei, Zhang, Xuantong, Zhang, Xueyao, Zhang, Yan, Zhang, Yinhong, Zhang, Yiyu, Zhang, Yongpeng, Zhang, Yuanyuan, Zhang, Yumei, Zhang, Zhenyu, Zhang, Zhijian, Zhao, Fengyi, Zhao, Jie, Zhao, Rong, Zhao, Shujun, Zhao, Tianchi, Zheng, Dongqin, Zheng, Hua, Zheng, Minshan, Zheng, Yangheng, Zhong, Weirong, Zhou, Jing, Zhou, Li, Zhou, Nan, Zhou, Shun, Zhou, Tong, Zhou, Xiang, Zhu, Jiang, Zhu, Kejun, Zhu, Zhihang, Zhuang, Bo, Zhuang, Honglin, Zong, Liang, and Zou, Jiaheng
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- 2021
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160. BCL-W expression associates with poor outcome in patients with peripheral T-cell lymphoma not otherwise specified
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Marques-Piubelli, Mario L., Solis, Luisa M., Parra, Edwin R., Castillo, Luis Malpica, Gouni, Sushanth, Nair, Ranjit, Chihara, Dai, Konopleva, Marina, Wistuba, Ignacio I., Iyer, Swaminathan P., Vega, Francisco, and Strati, Paolo
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- 2021
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161. Airborne Radiometric Surveys and Machine Learning Algorithms for Revealing Soil Texture
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Andrea Maino, Matteo Alberi, Emiliano Anceschi, Enrico Chiarelli, Luca Cicala, Tommaso Colonna, Mario De Cesare, Enrico Guastaldi, Nicola Lopane, Fabio Mantovani, Maurizio Marcialis, Nicola Martini, Michele Montuschi, Silvia Piccioli, Kassandra Giulia Cristina Raptis, Antonio Russo, Filippo Semenza, and Virginia Strati
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airborne gamma-ray spectroscopy ,non-linear machine learning ,potassium ,clay ,thorium ,sand ,Science - Abstract
Soil texture is key information in agriculture for improving soil knowledge and crop performance, so the accurate mapping of this crucial feature is imperative for rationally planning cultivations and for targeting interventions. We studied the relationship between radioelements and soil texture in the Mezzano Lowland (Italy), a 189 km2 agricultural plain investigated through a dedicated airborne gamma-ray spectroscopy survey. The K and Th abundances were used to retrieve the clay and sand content by means of a multi-approach method. Linear (simple and multiple) and non-linear (machine learning algorithms with deep neural networks) predictive models were trained and tested adopting a 1:50,000 scale soil texture map. The comparison of these approaches highlighted that the non-linear model introduces significant improvements in the prediction of soil texture fractions. The predicted maps of the clay and of the sand content were compared with the regional soil maps. Although the macro-structures were equally present, the airborne gamma-ray data permits us shedding light on finer features. Map areas with higher clay content were coincident with paleo-channels crossing the Mezzano Lowland in Etruscan and Roman periods, confirmed by the hydrographic setting of historical maps and by the geo-morphological features of the study area.
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- 2022
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162. Assessing the Phytochemical Profile and Potential of Traditional Herbal Infusions against Aldose Reductase through In Silico Studies and LC-MS/MS Analysis
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Thalia Tsiaka, Eftichia Kritsi, Dimitra Z. Lantzouraki, Paris Christodoulou, Diamantina Tsigrimani, Irini F. Strati, Vassilia J. Sinanoglou, and Panagiotis Zoumpoulakis
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herbal infusions ,in silico techniques ,molecular docking ,liquid chromatography-mass spectrometry (LC-MS/MS) ,aldose reductase (AR) ,phenolic compounds ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
In the current market, there is a growing interest in traditional herbal nutraceuticals. Therefore, herbal formulations have re-emerged as products with sought-after nutraceutical and disease-preventing properties. The health-promoting effects of herbal bioactives are attributed to the active phytoconstituents of these plants. Thus, the aim of the present study was to evaluate the putative nutraceutical effectiveness of the preparations of ten herbs (chamomile, purple coneflower, lemon verbena, pennyroyal, spearmint, oregano, marjoram, headed savory, sea buckthorn, and St. John’s wort) by combining in silico techniques and LC-MS/MS analysis. The binding potential of the selected phenolic compounds, according to literature and web databases, was investigated by using molecular target prediction tools. Aldose reductase (AR), an enzyme of polyol pathway which is related to hyperglycemic-induced pathologies, emerged as the most promising molecular target. The molecular docking results showed that rosmarinic acid, caftaric acid, naringenin, and quercetin presented the highest binding affinity. In a further step, the phytochemical profile of the examined infusions, obtained by LC-MS/MS analysis, revealed that the abovementioned compounds were present, mainly in the herbs of the Lamiaceae family, designating headed savory as the herbal infusion with possible significant inhibitory activity against AR.
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- 2022
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163. Response-adapted ultra-low-dose 4 Gy radiation as definitive therapy of gastric MALT lymphoma: a single-centre, pilot trial
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Gunther, Jillian R, Xu, Jie, Bhutani, Manoop S, Strati, Paolo, Fang, Penny Q, Wu, Susan Y, Dabaja, Bouthaina S, Dong, Wenli, Bhosale, Priya R, Flowers, Christopher R, Nair, Ranjit, Malpica Castillo, Luis, Fayad, Luis, Iyer, Swaminathan P, Parmer, Simrit, Wang, Michael, Lee, Hun Ju, Samaniego, Felipe, Westin, Jason, Ahmed, Sairah, Nze, Chijioke C, Jain, Preetesh, Neelapu, Sattva S, Rodriguez, Maria A, Chihara, Dai, Nastoupil, Loretta J, and Pinnix, Chelsea C
- Abstract
Given the favourable prognosis of patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, treatment-related toxicity should be minimised. We aimed to evaluate the efficacy of 4 Gy radiotherapy given in a response-adapted approach.
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- 2024
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164. Acalabrutinib for treatment of diffuse large B-cell lymphoma: results from a phase Ib study
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Paolo Strati, Sven de Vos, Jia Ruan, Kami J. Maddocks, Christopher R. Flowers, Simon Rule, Priti Patel, Yan Xu, Helen Wei, Melanie M. Frigault, Roser Calvo, and Martin J.S. Dyer
- Subjects
Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2021
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165. Transferring Complex Scientific Knowledge to Useable Products for Society: The Role of the Global Integrated Ocean Assessment and Challenges in the Effective Delivery of Ocean Knowledge
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Karen Evans, Tymon Zielinski, S. Chiba, Carlos Garcia-Soto, Henn Ojaveer, Chul Park, Renison Ruwa, Jörn Oliver Schmidt, Alan Simcock, Anastasia Strati, and Ca Thanh Vu
- Subjects
world ocean assessment ,ocean literacy ,science-policy interface ,sustainable development goals ,ocean management ,Environmental sciences ,GE1-350 - Abstract
The ocean provides essential services to human wellbeing through climate regulation, provision of food, energy and livelihoods, protection of communities and nurturing of social and cultural values. Yet despite the ocean’s key role for all life, it is failing as a result of unsustainable human practices. The first global integrated assessment of the marine environment, produced by the United Nations under The Regular Process for Global Reporting and Assessment of the State of the Marine Environment, including Socioeconomic Aspects (the World Ocean Assessment), identified an overall decline in ocean health. The second assessment, launched in April 2021, although recognising some bright spots and improvements, stresses ongoing decline in the ocean as a result of many unabated anthropogenic stressors on the ocean. This highlights that society, as a whole, does not fully recognise or value the importance of the ocean to their lives and impacts on the ocean caused by human activities. Further, recognition of the need for immediate and effective solutions for mitigating impacts and enabling ecosystem recovery, and the associated societal changes required is lacking. The United Nations 2030 Agenda for Sustainable Development and the United Nations Decade of Ocean Science for Sustainable Development 2021–2030 both recognize that sustainability is both a desired and essential pathway for ensuring the ocean can continue to provide the services society depends on. The World Ocean Assessment has an important role to play in increasing awareness of the ocean, the changes occurring in the ocean, the human activities causing those changes and the progress being made in reducing and mitigating the impacts of human activities on the marine environment. This paper outlines the knowledge brokering role that the Regular Process provides on ocean issues to all aspects of society from policy makers, ocean managers, ocean users to the public. It identifies the challenges faced by the Regular Process in successfully carrying out that role and lessons learned in achieving widespread uptake and recognition. Within the Decade of Ocean Science for Sustainable Development, solutions in the form of instructions or guidelines for the use of the assessment can be developed and implemented.
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- 2021
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166. A ticking clock for B cell tumors
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Strati, Paolo and Green, Michael R.
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- 2020
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167. Outcomes of first-line treatment for chronic lymphocytic leukemia with 17p deletion
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Strati, Paolo, Keating, Michael J, O'Brien, Susan M, Ferrajoli, Alessandra, Burger, Jan, Faderl, Stefan, Tambaro, Francesco Paolo, Jain, Nitin, and Wierda, William G
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Oncology and Carcinogenesis ,Rare Diseases ,Hematology ,Cancer ,Adult ,Aged ,Aged ,80 and over ,Antibodies ,Monoclonal ,Murine-Derived ,Antineoplastic Combined Chemotherapy Protocols ,Chromosome Deletion ,Chromosomes ,Human ,Pair 17 ,Disease-Free Survival ,Female ,Follow-Up Studies ,Humans ,Lenalidomide ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Male ,Middle Aged ,Retrospective Studies ,Rituximab ,Smith-Magenis Syndrome ,Thalidomide ,Treatment Outcome ,Cardiorespiratory Medicine and Haematology ,Immunology ,Cardiovascular medicine and haematology - Abstract
Although uncommon in treatment-naive patients with chronic lymphocytic leukemia, deletion 17p is a high-risk disease characteristic. We analyzed and reported outcomes for 63 patients with deletion 17p chronic lymphocytic leukemia who received first-line therapy at our institution; at time of first treatment, 81% had unmutated immunoglobulin heavy chain variable gene and 58% had complex karyotype. Forty-nine patients (76%) received first-line fludarabine, cyclophosphamide, rituximab-based therapy, 6 (11%) received rituximab-based and 8 (13%) received lenalidomide-based treatment. Overall, the complete plus nodular partial remission rate was 33%; on multivariable model, higher complete plus nodular partial remission rate was observed in patients with less than 50% cells positive for deletion 17p, and a higher probability of achieving at least a partial remission was observed with fludarabine, cyclophosphamide, rituximab-based treatment. After a median follow up of 33 months (range 1-89 months), the estimated median progression-free survival was 14 months (95% confidence interval 10-18) and estimated median overall survival was 63 months (95% confidence interval 43-83). In multivariable analysis, factors independently associated with longer progression-free survival were response to treatment and absence of complex karyotype. Achievement of complete plus nodular partial remission rate and mutated immunoglobulin heavy chain variable gene were independently associated with longer overall survival in multivariable model. Complex karyotype was associated with increased risk for Richter's transformation. New first-line strategies and agents must aim at both improving response and maintaining remission in patients with deletion 17p, particularly in the presence of complex karyotype.
- Published
- 2014
168. Fludarabine, cyclophosphamide and rituximab plus granulocyte macrophage colony-stimulating factor as frontline treatment for patients with chronic lymphocytic leukemia
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Strati, Paolo, Ferrajoli, Alessandra, Lerner, Susan, O’Brien, Susan, Wierda, William, Keating, Michael J, and Faderl, Stefan
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Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Rare Diseases ,Infectious Diseases ,Clinical Trials and Supportive Activities ,Hematology ,Clinical Research ,Cancer ,Lymphoma ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Good Health and Well Being ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Antibodies ,Monoclonal ,Murine-Derived ,Antineoplastic Combined Chemotherapy Protocols ,Cyclophosphamide ,Female ,Granulocyte-Macrophage Colony-Stimulating Factor ,Humans ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Male ,Middle Aged ,Neoplasm Staging ,Rituximab ,Treatment Outcome ,Vidarabine ,Young Adult ,Clinical Sciences ,Immunology ,Cardiovascular medicine and haematology - Abstract
Fludarabine, cyclophosphamide and rituximab (FCR), the standard of care for the frontline treatment of patients with chronic lymphocytic leukemia (CLL), is associated with a high rate of neutropenia and infectious complications. Granulocyte macrophage colony-stimulating factor (GM-CSF) reduces myelosuppression and can potentiate rituximab activity. We conducted a clinical trial combining GM-CSF with FCR for frontline treatment of 60 patients with CLL. Eighty-six percent completed all six courses and 18% discontinued GM-CSF for toxicity: grade 3-4 neutropenia was observed in 30% of cycles, and severe infections in 16% of cases. The overall response rate was 100%. Both median event-free survival (EFS) and overall survival (OS) have not been reached. Longer EFS was associated with favorable cytogenetics. GM-CSF led to a lower frequency of infectious complications than in the historical FCR group, albeit similar EFS and OS.
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- 2014
169. HCVAD plus imatinib or dasatinib in lymphoid blastic phase chronic myeloid leukemia
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Strati, Paolo, Kantarjian, Hagop, Thomas, Deborah, O'Brien, Susan, Konoplev, Sergej, Jorgensen, Jeffrey L, Luthra, Raja, Abruzzo, Lynne, Jabbour, Elias, Quintas‐Cardama, Alfonso, Borthakur, Gautam, Faderl, Stefan, Ravandi, Farhad, and Cortes, Jorge
- Subjects
Biomedical and Clinical Sciences ,Cardiovascular Medicine and Haematology ,Clinical Sciences ,Oncology and Carcinogenesis ,Orphan Drug ,Transplantation ,Rare Diseases ,Cancer ,Hematology ,Stem Cell Research - Nonembryonic - Human ,Genetics ,Clinical Research ,Stem Cell Research ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Adult ,Aged ,Antineoplastic Combined Chemotherapy Protocols ,Benzamides ,Blast Crisis ,Cyclophosphamide ,Cytarabine ,Dasatinib ,Dexamethasone ,Doxorubicin ,Female ,Hematopoietic Stem Cell Transplantation ,Humans ,Imatinib Mesylate ,Leukemia ,Myelogenous ,Chronic ,BCR-ABL Positive ,Male ,Methotrexate ,Middle Aged ,Piperazines ,Pyrimidines ,Thiazoles ,Vincristine ,HCVAD ,blast phase ,chronic myeloid leukemia ,lymphoid variant ,tyrosine kinase inhibitors ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Public health - Abstract
BackgroundChronic myeloid leukemia (CML) may progress to blast phase (BP) at the rate of 1% to 1.5% per year. With the use of single-agent tyrosine kinase inhibitors, median overall survival ranges between 7 and 11 months.MethodsThe outcome was analyzed for 42 patients with lymphoid BP-CML who were treated with hyperfractionated cyclophosphamide, vincristine, Adriamycin, dexamethasone (HCVAD) plus imatinib or dasatinib.ResultsComplete hematological response was achieved in 90% of patients, complete cytogenetic remission in 58%, and complete molecular remission in 25%. Flow cytometry minimal residual disease negativity was achieved by 42% of evaluable patients after induction. Eighteen patients received allogeneic stem cell transplant (SCT) while in first complete hematological response. Median remission duration was 14 months and was longer among SCT recipients (P = .01) on multivariate analysis. Median overall survival was 17 months (range, 7-27 months) and was longer among SCT recipients (P
- Published
- 2014
170. Outcomes with Bridging Radiation Therapy Prior to CAR-T Cell Therapy in Pts with Aggressive B Cell Lymphomas
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Manzar, G.S., primary, Wu, S.Y., additional, Dudzinski, S.O., additional, Jallouk, A., additional, Yoder, A.K., additional, Nasr, L.F., additional, Corrigan, K.L., additional, Gunther, J.R., additional, Ahmed, S., additional, Fayad, L., additional, Nair, R., additional, Steiner, R., additional, Westin, J., additional, Neelapu, S.S., additional, Dabaja, B., additional, Strati, P., additional, Nastoupil, L., additional, Pinnix, C.C., additional, Fang, P., additional, and Rooney, M.K., additional
- Published
- 2023
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171. Ultra Low-Dose Radiation for Extranodal Marginal Zone Lymphoma of the Lung
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Wu, S.Y., primary, Gunther, J.R., additional, Manzar, G.S., additional, Corrigan, K.L., additional, Damron, E.P., additional, Schrank, B.R., additional, Nasr, L.F., additional, Chihara, D., additional, Malpica Castillo, L.E., additional, Nair, R., additional, Steiner, R., additional, Jain, P., additional, Neelapu, S.S., additional, Samaniego, F., additional, Rodriguez, M.A., additional, Strati, P., additional, Nastoupil, L., additional, Dabaja, B., additional, Pinnix, C.C., additional, and Fang, P., additional
- Published
- 2023
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172. Outcomes and Toxicities in Patients with Diffuse Large B-Cell Lymphoma of the Gastrointestinal Tract
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Cha, E., primary, Manzar, G.S., additional, Corrigan, K.L., additional, Yoder, A.K., additional, Schrank, B.R., additional, Nasr, L.F., additional, Gunther, J.R., additional, Strati, P., additional, Ahmed, S., additional, Fayad, L., additional, Nair, R., additional, Steiner, R., additional, Westin, J., additional, Nastoupil, L., additional, Neelapu, S.S., additional, Pinnix, C.C., additional, Dabaja, B., additional, Wu, S.Y., additional, and Fang, P., additional
- Published
- 2023
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173. Characterization of Lymphopenia during Bridging Radiation Therapy Prior to CAR-T Cell Therapy in Patients with Aggressive B Cell Lymphomas
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Manzar, G.S., primary, Wu, S.Y., additional, Dudzinski, S.O., additional, Rooney, M.K., additional, Jallouk, A., additional, Yoder, A.K., additional, Nasr, L.F., additional, Gunther, J.R., additional, Sallard, G., additional, Ahmed, S., additional, Fayad, L., additional, Nair, R., additional, Steiner, R., additional, Westin, J., additional, Nastoupil, L., additional, Neelapu, S.S., additional, Dabaja, B., additional, Pinnix, C.C., additional, Strati, P., additional, and Fang, P., additional
- Published
- 2023
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174. ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens
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Michele Proietti, Lisa Perruzza, Daniela Scribano, Giovanni Pellegrini, Rocco D’Antuono, Francesco Strati, Marco Raffaelli, Santiago F. Gonzalez, Marcus Thelen, Wolf-Dietrich Hardt, Emma Slack, Mauro Nicoletti, and Fabio Grassi
- Subjects
Science - Abstract
The generation of protective secretory IgA is a desired outcome of oral vaccination. Here, the authors show that the depletion of intestinal ATP significantly improves the production and response of high-affinity IgA against both live and inactivated oral vaccines.
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- 2019
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175. In Vitro and In Silico Studies to Assess Edible Flowers’ Antioxidant Activities
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Eftichia Kritsi, Thalia Tsiaka, Alexandros-George Ioannou, Vassiliki Mantanika, Irini F. Strati, Irene Panderi, Panagiotis Zoumpoulakis, and Vassilia J. Sinanoglou
- Subjects
edible flowers ,phenolic compounds ,in vitro antioxidant and antiradical activity ,ATR-FTIR ,molecular docking ,myeloperoxidase ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The incorporation of edible flowers in the human diet and culinary preparations dates back to ancient times. Nowadays, edible flowers have gained great attention due to their health-promoting and nutritive effects and their widespread acceptance by consumers. Therefore, edible flowers are ideal candidates for use in the design and development of functional foods and dietary supplements, representing a new and promising trend in the food industry. Thus, the present study attempts to assess the potential of various edible flowers against oxidative stress by applying a combination of in vitro, in silico and spectroscopic techniques. Specifically, the spectroscopic profiles of edible flower extracts were evaluated using ATR-FTIR spectroscopy, while their total phenolic contents and antioxidant/antiradical activities were determined spectrophotometrically. The most abundant phytochemicals in the studied flowers were examined as enzyme inhibitors through molecular docking studies over targets that mediate antioxidant mechanisms in vivo. Based on the results, the red China rose followed by the orange Mexican marigold exhibited the highest TPCs and antioxidant activities. All samples showed the characteristic FTIR band of the skeletal vibration of phenolic aromatic rings. Phenolic compounds seem to exhibit antioxidant activity with respect to NADPH oxidase, myeloperoxidase (MP), cytochrome P450 and, to a lesser extent, xanthine oxidase (XO) enzymes.
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- 2022
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176. Combining Precision Viticulture Technologies and Economic Indices to Sustainable Water Use Management
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Adele Finco, Deborah Bentivoglio, Giulia Chiaraluce, Matteo Alberi, Enrico Chiarelli, Andrea Maino, Fabio Mantovani, Michele Montuschi, Kassandra Giulia Cristina Raptis, Filippo Semenza, Virginia Strati, Filippo Vurro, Edoardo Marchetti, Manuele Bettelli, Michela Janni, Emiliano Anceschi, Carlo Sportolaro, and Giorgia Bucci
- Subjects
case study ,climate change ,crop water stress ,digital technologies ,economic water productivity ,IoT platform ,Hydraulic engineering ,TC1-978 ,Water supply for domestic and industrial purposes ,TD201-500 - Abstract
The scarcity of water due to climate change is endangering worldwide the production, quality, and economic viability of growing wine grapes. One of the main mitigation measures to be adopted in the viticulture sector will be an adequate irrigation strategy. Irrigation involves an increasing demand for water, a natural limited resource with increasing availability problems for the foreseeable future. Therefore, the development of a precision irrigation system, which is able to manage the efficient use of water and to monitor the crop water stress, is an important research topic for viticulture. This paper, through the analysis of a case study, aims to describe the prototype of a software platform that integrates data coming from different innovative remote and proximal sensors to monitor the hydric stress status of the vineyard. In addition, by using a cost analysis of grape cultivation and implementing economic indices, this study examines the conditions by which irrigation strategies may be economically justified, helping the decision-making process. By combining different sensors, the platform makes it possible to assess the spatial and temporal variability of water in vineyards. In addition, the output data of the platforming, matched with the economic indices, support the decision-making process for winemakers to optimize and schedule water use under water-scarce conditions.
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- 2022
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177. Myelosuppression after frontline fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia
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Strati, Paolo, Wierda, William, Burger, Jan, Ferrajoli, Alessandra, Tam, Constantine, Lerner, Susan, Keating, Michael J, and O'Brien, Susan
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Hematology ,Clinical Research ,Rare Diseases ,Patient Safety ,Cancer ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Antibodies ,Monoclonal ,Murine-Derived ,Antineoplastic Combined Chemotherapy Protocols ,Clinical Trials ,Phase II as Topic ,Cyclophosphamide ,Female ,Humans ,Immune Tolerance ,Immunotherapy ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Male ,Middle Aged ,Myeloablative Agonists ,Neoadjuvant Therapy ,Pancytopenia ,Retrospective Studies ,Rituximab ,Treatment Outcome ,Vidarabine ,Young Adult ,chronic lymphocytic leukemia ,combination of fludarabine ,cyclophosphamide ,and rituximab ,cytopenia ,prognosis ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis ,Public health - Abstract
BackgroundThe combination of fludarabine, cyclophosphamide, and rituximab (FCR) has produced improved response rates and a prolonged survival in patients with chronic lymphocytic leukemia (CLL). However, its therapeutic power is counterbalanced by significant hematologic toxicity. Persistent and new-onset cytopenia after the completion of FCR raise concern about disease recurrence, the development of therapy-related myeloid malignancies (TRMM), and infections.MethodsA total of 207 patients with CLL who achieved complete response, complete response with incomplete bone marrow recovery, or nodular partial remission were analyzed after frontline FCR therapy.ResultsThree months after the completion of therapy, 35% of patients had developed grade 2 to 4 cytopenia (according to Common Terminology Criteria for Adverse Events [version 4.0]). Factors found to be associated with cytopenia at 3 months after therapy were older age, advanced Rai stage disease, and lower baseline blood counts. Moreover, patients with cytopenia were less likely to have completed 6 courses of therapy with FCR. At 6 months and 9 months after therapy, the prevalence of grade 2 to 4 cytopenia was 24% and 12%, respectively. No differences in progression-free survival and overall survival were noted between cytopenic and noncytopenic patients or between patients with persistent and new-onset cytopenia. The prevalence of TRMM was 2.3% and did not differ significantly between cytopenic and noncytopenic patients or between those with persistent and new-onset disease. Late infections were more common in patients who were cytopenic at 9 months (38%) and were mostly bacterial (67%).ConclusionsCytopenia after the completion of therapy is a common complication of frontline FCR that improves over time, particularly for new-onset cases. The presence of persistent cytopenia (lasting up to 9 months after the completion of therapy) should not raise concern about CLL recurrence of the development of TRMM, but should encourage surveillance for bacterial infections for an additional 9 months.
- Published
- 2013
178. Editorial: HPV and Host Interaction
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Domenico Mattoscio, Tarik Gheit, Katerina Strati, and Assunta Venuti
- Subjects
cervical cancer ,head and neck (H&N) cancer ,HPV – human papillomavirus ,non melanoma skin cancer ,beta HPV types ,alpha HPVs ,Microbiology ,QR1-502 - Published
- 2021
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179. Editorial: Innovative Methods for Non-invasive Monitoring of Hydrological Processes From Field to Catchment Scale
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Heye R. Bogena, Virginia Strati, Andreas Güntner, Clara C. Chew, and Martin Schrön
- Subjects
soil moisture ,non-invasive measurement techniques ,cosmic-ray neutron probes ,field scale ,catchment ,land surface ,Environmental technology. Sanitary engineering ,TD1-1066 - Published
- 2021
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180. Comparative Effectiveness of Remestemcel-L-rknd versus Ruxolitinib in Pediatric Patients with Steroid-Refractory Acute Graft-Versus-Host Disease using Simulated Treatment Comparisons
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Gabriel Tremblay, Dimitrios Tomaras, Eric Strati, and Anna Forsythe
- Subjects
Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
**Background:** Allogeneic hematopoietic stem cell transplantation (allo-HSCT) can be a lifesaving treatment for hematologic malignancies, but acute graft-versus-host-disease (aGVHD) is a potentially deadly adverse effect experienced by up to half of allo-HSCT recipients. Inadequate response to steroid therapy for aGVHD is associated with poor prognosis and high mortality, including among pediatric patients, who are the focus of this study. Ruxolitinib and remestemcel-L-rknd were evaluated for the treatment of steroid-refractory (SR) aGVHD in two separate single-arm trials. To effectively compare the safety and efficacy of these treatments without a head-to-head trial, a simulated treatment comparison (STC) was conducted. **Methods:** Regression techniques were used to adjust individual patient-level data from the remestemcel-L-rknd trial to mutually reported baseline characteristics from the ruxolitinib trial. Outcomes of interest included a 28-day overall response rate (ORR), a 28-day ORR in the grade III-IV aGVHD population, and adverse events (AEs). **Results:** In the full populations, the STC of risk ratios (RRs) found treatment with remestemcel-L-rknd to be associated with a numerical but not statistically significant improvement in the 28-day ORR versus ruxolitinib. In the grade III-IV aGVHD sub-group, the STC showed significantly improved 28-day ORR for remestemcel-L-rknd versus ruxolitinib (_P_=0.04). Remestemcel-L-rknd was also associated with improved safety outcomes (_P_
- Published
- 2021
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181. Perceived Challenge, Teacher Support, and Teacher Obstruction as Predictors of Student Engagement
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Strati, Anna D., Schmidt, Jennifer A., and Maier, Kimberly S.
- Abstract
This study explored associations between students' perceptions of challenge, teacher-provided support and obstruction, and students' momentary academic engagement in high school science classrooms. Instrumental and emotional dimensions of support and obstruction were examined separately, and analyses tested whether the relationship between challenge and engagement was moderated by teacher support, teacher obstruction, and individual characteristics like gender and grade level. Students' perceptions of challenge were positively related to their momentary reports of engagement in science learning activities, while teachers' instrumental support was positively associated with engagement across all levels of perceived challenge. Even though teachers' provision of emotional support was not predictive of student engagement, teachers' emotional obstruction was negatively associated with student engagement. Teachers' instrumental obstruction had less consistent associations with student engagement, and was only associated with declines in engagement during those moments when students perceived greater challenge in class. Both gender and grade level emerged as moderators of the relationship between challenge and engagement. Results are discussed in terms of implications for future research and instructional practice.
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- 2017
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182. The Importance of Complementary PCR Analysis in Addition to Serological Testing for the Detection of Transmission Sources of Brucella spp. in Greek Ruminants
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Anthimia Batrinou, Irini F. Strati, Andreas G. Tsantes, Joseph Papaparaskevas, Ioannis Dimou, Dimitrios Vourvidis, Anna Kyrma, Dionysis Antonopoulos, Panagiotis Halvatsiotis, and Dimitra Houhoula
- Subjects
brucellosis ,ruminants ,PCR ,antibodies ,DNA ,RBPT ,Veterinary medicine ,SF600-1100 - Abstract
The early and accurate diagnosis of brucellosis, a ubiquitous zoonotic infection, is significant in preventing disease transmission. This study aimed to assess the infection rate of Brucella spp. in ruminants and to evaluate the agreement between a serological test and a molecular method for the detection of infected cases. Blood and milk samples of 136 ruminants were analyzed using two laboratory methods: the Rose Bengal plate (RBP) test to detect B. abortus and B. melitensis antibodies and the molecular polymerase chain reaction (PCR) method for the presence of bacterial DNA. The agreement between the methods was assessed using the kappa statistic. Based on the RBP test, there were 12 (8.8%) seropositive animals (10 sheep and 2 cows), while 2 (1.4%) samples were positive on PCR analysis. The positive PCR samples were from seronegative cow samples on RBP testing. There was slight agreement (k = −0.02) between the two methods, which was not statistically significant. Our results indicate that complementary molecular methods are useful to detect the bacteria in infected animals that are seronegative due to an early stage of infection. Therefore, a combination of molecular methods and serological tests can be applied to detect brucellosis in ruminants efficiently.
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- 2022
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183. Treating Older Patients with Chronic Lymphocytic Leukemia: A Personalized Approach
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Strati, Paolo and Ferrajoli, Alessandra
- Published
- 2019
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184. Ruxolitinib therapy is associated with improved renal function in patients with primary myelofibrosis
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Strati, Paolo, Abdelrahim, Maen, Selamet, Umut, Page, Valda D., Pierce, Sherry A., Verstovsek, Srdan, and Abudayyeh, Ala
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- 2019
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185. Composition and geographic variation of the bacterial microbiota associated with the coelomic fluid of the sea urchin Paracentrotus lividus
- Author
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Faddetta, Teresa, Ardizzone, Francesco, Faillaci, Francesca, Reina, Chiara, Palazzotto, Emilia, Strati, Francesco, De Filippo, Carlotta, Spinelli, Giovanni, Puglia, Anna Maria, Gallo, Giuseppe, and Cavalieri, Vincenzo
- Published
- 2020
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186. Authentication of olive oil based on DNA analysis
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A. Batrinou, I. F. Strati, D. Houhoula, J. Tsaknis, and V. J. Sinanoglou
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authentication ,genetic markers ,(hrm) ,olive oil ,(snps) ,(ssr) ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Olive oil, which has been produced mainly in the Mediterranean area since the ancient times, has a high nutritional value linked to many health benefits. Extra virgin, which is the purest form of olive oil, has excellent quality and premium prices. Many cases of adulteration and fraud necessitate the development of reliable and accurate methods for olive oil authentication. DNA-based methods analyze the residual DNA extracted from olive oil and use molecular markers for genetic identification of different species, subspecies or cultivars because these markers act as signs which reflect distinct genetic profiles. This study reviews the process by which DNA from olive oil is extracted and analyzed by the most recently used markers in the authentication of olive oil, such as Simple Sequence Repeats (SSR) or microsatellites and the single nucleotide polymorphisms (SNPs). Methods of analysis such as qPCR and digital PCR are also discussed with a special emphasis placed on the method of High-Resolution Melting (HRM), a post-polymerase chain reaction method, which enables rapid, high performing identification of genetic variants in the DNA regions of interest without sequencing, and may differentiate very similar cultivars which differ in only one nucleotide in a specific locus.
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- 2020
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187. Hematopoietic recovery and immune reconstitution after axicabtagene ciloleucel in patients with large B-cell lymphoma
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Paolo Strati, Ankur Varma, Sherry Adkins, Loretta J. Nastoupil, Jason Westin, Fredrick B. Hagemeister, Nathan H. Fowler, Hun J. Lee, Luis E. Fayad, Felipe Samaniego, Sairah Ahmed, Yiming Chen, Sandra Horowitz, Sara Arafat, Swapna Johncy, Partow Kebriaei, Victor Eduardo Mulanovich, Ella Ariza Heredia, and Sattva S. Neelapu
- Subjects
Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 may be associated with long-term adverse effects such as cytopenia and immune deficiency. In order to characterize these late events, we analyzed 31 patients with relapsed or refractory large B-cell lymphoma treated with axicabtagene ciloleucel at our institution on two clinical trials, ZUMA-1 (clinicaltrials gov. Identifier: NCT02348216) and ZUMA-9 (clinicaltrials gov. Identifier: NCT03153462). Complete blood counts, lymphocyte subsets, and immunoglobulin levels were measured serially until month 24 or progression. Fifteen (48%) patients had grade 3-4 cytopenia, including anemia (five, 16%), neutropenia (nine, 29%), or thrombocytopenia (13, 42%) at day 30. Cytopenia at day 30 was not significantly associated with later diagnosis of myelodysplasia. Among patients with ongoing remission, grade 3-4 cytopenia was observed in one of nine (11%) at 2 years. While peripheral CD8+ T cells recovered early, CD4+ T-cell recovery was delayed with a count of
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- 2020
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188. New paradigm for radiation in multiple myeloma: lower yet effective dose to avoid radiation toxicity
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Adnan Elhammali, Behrang Amini, Ethan B. Ludmir, Jillian R. Gunther, Sarah A. Milgrom, Chelsea C. Pinnix, Therese Andraos, Alison Yoder, Donna Weber, Robert Orlowski, Elisabet Manasanch, Krina Patel, Paolo Strati, Ranjit Nair, Hans C. Lee, Sheeba Thomas, Swaminathan Iyer, Gregory Kaufmann, Naveen Garg, and Bouthaina S. Dabaja
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2020
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189. Pre-treatment maximum standardized uptake value predicts outcome after frontline therapy in patients with advanced stage follicular lymphoma
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Paolo Strati, Mohamed Amin Ahmed, Nathan H. Fowler, Loretta J. Nastoupil, Felipe Samaniego, Luis E. Fayad, Fredrick B. Hagemeister, Jorge E. Romaguera, Alma Rodriguez, Michael Wang, Jason R. Westin, Chan Cheah, Mansoor Noorani, Lei Feng, Richard E. Davis, and Sattva S. Neelapu
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
The impact of pre-treatment maximum standardized uptake value (SUVmax) on the outcome of follicular lymphoma (FL) following specific frontline regimens has not been explored. We performed a retrospective analysis of 346 patients with advanced stage follicular lymphoma (FL) without histological evidence of transformation, and analyzed the impact of SUVmax on outcome after frontline therapy. Fifty-two (15%) patients had a SUVmax >18, and a large lymph node ≥6 cm was the only factor associating with SUVmax >18 on multivariate analysis (odds ratio 2.7, 95% confidence interval [CI]: 1.3-5.3, P=0.006). The complete response rate was significantly lower among patients treated with non-anthracycline-based regimens if SUVmax was >18 (45% vs. 92%, P18 was associated with significantly shorter progression-free survival among patients treated with non-anthracycline-based regimens (77 months vs. not reached, P=0.02), but not among patients treated with R-CHOP (P=0.73). SUVmax >18 associated with shorter overall survival (OS) both in patients treated with R-CHOP (8-year OS 70% vs. 90%, P=0.02) and non-anthracycline-based frontline regimens (8-year OS 50% vs. 85%, P=0.001). In conclusion, pre-treatment PET scan has prognostic and predictive value in patients with advanced stage FL receiving frontline treatment.
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- 2020
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190. Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection
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Lisa Perruzza, Stefano Jaconi, Gloria Lombardo, Debora Pinna, Francesco Strati, Diego Morone, Frauke Seehusen, Yue Hu, Sakshi Bajoria, Jian Xiong, Ozan Selahattin Kumru, Sangeeta Bagai Joshi, David Bernard Volkin, Renato Piantanida, Fabio Benigni, Fabio Grassi, Davide Corti, and Matteo Samuele Pizzuto
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secretory IgA ,monoclonal antibodies ,prophylaxis ,Campylobacter ,flagellar-capping protein ,FliD ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Campylobacter infection is one of the most common causes of bacterial gastroenteritis worldwide and a major global health threat due to the rapid development of antibiotic resistance. Currently, there are no vaccines approved to prevent campylobacteriosis, and rehydration is the main form of therapy. Secretory immunoglobulin A (SIgA) is the main antibody class found in mucous secretions, including human milk, and serves as the first line of defense for the gastrointestinal epithelium against enteric pathogens. In this study, we describe the prophylactic activity of orally delivered recombinant SIgA generated from two human monoclonal antibodies (CAA1 and CCG4) isolated for their reactivity against the flagellar-capping protein FliD, which is essential for bacteria motility and highly conserved across Campylobacter species associated with severe enteritis. In an immunocompetent weaned mouse model, a single oral administration of FliD-reactive SIgA CAA1 or CCG4 at 2 h before infection significantly enhances Campylobacter clearance at early stages post-infection, reducing the levels of inflammation markers associated with epithelial damage and polymorphonuclear (PMN) cells infiltration in the cecum lamina propria. Our data indicate that the prophylactic activity of CAA1 and CCG4 is not only dependent on the specificity to FliD but also on the use of the SIgA format, as the immunoglobulin G (IgG) versions of the same antibodies did not confer a comparable protective effect. Our work emphasizes the potential of FliD as a target for the development of vaccines and supports the concept that orally administered FliD-reactive SIgA can be developed to prevent or mitigate the severity of Campylobacter infections as well as the development of post-infection syndromes.
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- 2020
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191. Prognostic impact of indoleamine 2,3-dioxygenase 1 (IDO1) mRNA expression on circulating tumour cells of patients with head and neck squamous cell carcinoma
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Amanda Psyrri, Evangelos Giotakis, Panagiota Economopoulou, Athina Kladi-Skandali, Areti Strati, George Koytsodontis, Efthymios Kirodimos, Pavlos Maragoudakis, Eleni Gagari, Eirini Maratou, George Dimitriadis, Ioannis Kotsantis, Elena Vagia, Maria Anastasiou, Maria Gkotzamanidou, George Kavourakis, and Evi Lianidou
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background We sought to determine the prognostic role of indoleamine 2,3-dioxygenase 1 (IDO1) by evaluating IDO1 expression in circulating tumour cells (CTCs) at baseline and after completion of chemoradiotherapy in patients with locally advanced (LA) head and neck squamous cell carcinoma (HNSCC) treated with curative intent.Methods In a prospective cohort of 113 patients with LA HNSCC, we evaluated expression of IDO1 in the EpCAM+ CTC fraction at baseline and after cisplatin chemoradiation. The prognostic value of combined programmed cell death ligand-1 (PDL-1) and IDO1 expression was assessed.Results IDO1 was significantly overexpressed at baseline compared with the post-treatment counterparts (p=0.007). IDO1 messenger RNA (mRNA) expression at baseline was associated with better survival in terms of progression-free survival (PFS) (HR=0.19, p=0.017). Post-treatment IDO1 mRNA levels were correlated with unfavourable prognosis in terms of overall survival (OS) (HR=3.27, p=0.008). Patients with combined decreased expression levels of PDL-1 and IDO1 after treatment exhibited superior PFS (p=0.043) and OS (p=0.021).Conclusions Our results strongly suggest that IDO1 mRNA expression is an independent prognostic factor for clinical outcome. Our study provides useful information for future trials combining chemoradiation with immune checkpoint inhibitors and IDO1 inhibitors.
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- 2020
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192. CAR T-Cell Therapy for B-Cell non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia: Clinical Trials and Real-World Experiences
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Candida Vitale and Paolo Strati
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CAR T cells ,indolent B-cell lymphomas ,aggressive B-cell lymphomas ,chronic lymphocytic leukemia ,clinical trials ,real-world experience ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Chimeric antigen receptor-modified (CAR) T cells targeting CD19 have revolutionized the treatment of relapsed or refractory aggressive B-cell lymphomas, and their use has increased the cure rate for these cancers from 10 to 40%. Two second-generation anti-CD19 CAR T-cell products, axicabtagene ciloleucel and tisagenlecleucel, have been approved for use in patients, and the approval of a third product, lisocabtagene maraleucel, is expected in 2020. The commercial availability of the first two products has facilitated the development of real-world experience in treating relapsed or refractory aggressive B-cell lymphomas, shed light on anti-CD19 CAR T-cell products' feasibility in trial-ineligible patients, and raised the need for strategies to mitigate the adverse effects associated with anti-CD19 CAR T-cell therapy, such as cytokine release syndrome, neurotoxicity, and cytopenia. In addition, promising clinical data supporting the use of anti-CD19 CAR T-cell therapy in patients with indolent B-cell lymphomas or chronic lymphocytic leukemia have recently become available, breaking the paradigm that these conditions are not curable. Multiple clinical CAR T-cell therapy-based trials are ongoing. These include studies comparing CAR T-cell therapy to autologous stem cell transplantation or investigating their use at earlier stages of disease, novel combinations, and novel constructs. Here we provide a thorough review on the use of the anti-CD19 CAR T-cell products axicabtagene ciloleucel, tisagenlecleucel and lisocabtagene maraleucel in patients with indolent or aggressive B-cell lymphoma or with chronic lymphocytic leukemia, and present novel CAR T cell-based approaches currently under investigation in these disease settings.
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- 2020
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193. Human papillomavirus E7 binds Oct4 and regulates its activity in HPV-associated cervical cancers.
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Theofano Panayiotou, Stella Michael, Apostolos Zaravinos, Ece Demirag, Charis Achilleos, and Katerina Strati
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Immunologic diseases. Allergy ,RC581-607 ,Biology (General) ,QH301-705.5 - Abstract
Octamer binding transcription factor-4 (Oct4), is highly expressed in stem cells and has indispensable roles in pluripotency and cellular reprogramming. In contrast to other factors used for cellular reprogramming, a role for Oct4 outside embryonic stem cells has been elusive and highly controversial. Emerging evidence implicates Oct4 in the carcinogenic process, but the mechanism through which Oct4 may be functioning in cancers is not fully appreciated. Here, we provide evidence that Oct4 is expressed in human cervical cancer and this expression correlates with the presence of the human papillomavirus (HPV) oncogenes E6 and E7. Surprisingly, the viral oncogenes can complement exogenously provided Oct4 in reprogramming assays, providing functional validation for their ability to activate Oct4 transcription in Mouse Embryonic Fibroblasts (MEFs). To interrogate potential roles of Oct4 in cervical cancers we knocked-down Oct4 in HPV(+) (HeLa & CaSki) and HPV(-) (C33A) cervical cancer cell lines and found that Oct4 knockdown attenuated clonogenesis, only in the HPV(+) cells. More unexpectedly, cell proliferation and migration, were differentially affected in HPV(+) and HPV(-) cell lines. We provide evidence that Oct4 interacts with HPV E7 specifically at the CR3 region of the E7 protein and that introduction of the HPV oncogenes in C33A cells and human immortalised keratinocytes generates Oct4-associated transcriptional and phenotypic patterns, which mimic those seen in HPV(+) cells. We propose that a physical interaction of Oct4 with E7 regulates its activity in HPV(+) cervical cancers in a manner not seen in other cancer types.
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- 2020
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194. A phase 1 trial of alisertib and romidepsin for relapsed/refractory aggressive B-cell and T-cell lymphomas
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Paolo Strati, Loretta J. Nastoupil, Richard E Davis, Luis E. Fayad, Nathan Fowler, Fredrick B. Hagemeister, Larry Kwak, Yasuhiro Oki, Michael Wang, Jason Westin, Charnelle E. Ruben, Emily T. Wesson, Richard Piekarz, Michelle A. Fanale, and Hun Ju Lee
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2020
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195. Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis
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Demetris Iacovides, Charalambos Loizides, Georgios Mitsis, and Katerina Strati
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Computer applications to medicine. Medical informatics ,R858-859.7 ,Science (General) ,Q1-390 - Abstract
We have performed whole transcriptome sequencing of 5-FU resistant and 5-FU sensitive tumors generated in a mouse model of de novo carcinogenesis that closely recapitulates tumor initiation, progression and maintenance in vivo. Tumors were generated using the DMBA/TPA model of chemically induced carcinogenesis [1], tumor-bearing mice were subsequently treated with 5-FU, and tumor growth as well as response to treatment was monitored by measuring tumor volume twice a week. Based on these measurements, we selected two 5-FU resistant and two 5-FU sensitive tumors and performed whole transcriptome sequencing and in order to identify differentially expressed transcripts between the two sets. Data obtained is deposited and available through NCBI SRA (reference number SRP155180 – https://www.ncbi.nlm.nih.gov/sra/?term=SRP155180).
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- 2018
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196. Intestinal Candida parapsilosis isolates from Rett syndrome subjects bear potential virulent traits and capacity to persist within the host
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Francesco Strati, Antonio Calabrò, Claudio Donati, Claudio De Felice, Joussef Hayek, Olivier Jousson, Silvia Leoncini, Daniela Renzi, Lisa Rizzetto, Carlotta De Filippo, and Duccio Cavalieri
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Rett syndrome ,Candida parapsilosis ,Dysbiosis ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Abstract Background Rett syndrome (RTT) is a neurological disorder mainly caused by mutations in MeCP2 gene. It has been shown that MeCP2 impairments can lead to cytokine dysregulation due to MeCP2 regulatory role in T-helper and T-reg mediated responses, thus contributing to the pro-inflammatory status associated with RTT. Furthermore, RTT subjects suffer from an intestinal dysbiosis characterized by an abnormal expansion of the Candida population, a known factor responsible for the hyper-activation of pro-inflammatory immune responses. Therefore, we asked whether the intestinal fungal population of RTT subjects might contribute the sub-inflammatory status triggered by MeCP2 deficiency. Methods We evaluated the cultivable gut mycobiota from a cohort of 50 RTT patients and 29 healthy controls characterizing the faecal fungal isolates for their virulence-related traits, antifungal resistance and immune reactivity in order to elucidate the role of fungi in RTT’s intestinal dysbiosis and gastrointestinal physiology. Results Candida parapsilosis, the most abundant yeast species in RTT subjects, showed distinct genotypic profiles if compared to healthy controls’ isolates as measured by hierarchical clustering analysis from RAPD genotyping. Their phenotypical analysis revealed that RTT’s isolates produced more biofilm and were significantly more resistant to azole antifungals compared to the isolates from the healthy controls. In addition, the high levels of IL-1β and IL-10 produced by peripheral blood mononuclear cells and the mixed Th1/Th17 cells population induced by RTT C. parapsilosis isolates suggest the capacity of these intestinal fungi to persist within the host, being potentially involved in chronic, pro-inflammatory responses. Conclusions Here we demonstrated that intestinal C. parapsilosis isolates from RTT subjects hold phenotypic traits that might favour the previously observed low-grade intestinal inflammatory status associated with RTT. Therefore, the presence of putative virulent, pro-inflammatory C. parapsilosis strains in RTT could represent an additional factor in RTT’s gastrointestinal pathophysiology, whose mechanisms are not yet clearly understood.
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- 2018
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197. Characterization of Bacterial Microbiota of P.D.O. Feta Cheese by 16S Metagenomic Analysis
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Panagiotis Papadakis, Spyros Konteles, Anthimia Batrinou, Sotiris Ouzounis, Theofania Tsironi, Panagiotis Halvatsiotis, Efstathia Tsakali, Jan F. M. Van Impe, Despina Vougiouklaki, Irini F. Strati, and Dimitra Houhoula
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feta cheese ,16S metagenomic analysis ,microbiota biodiversity ,Biology (General) ,QH301-705.5 - Abstract
Background: The identification of bacterial species in fermented PDO (protected designation of origin) cheese is important since they contribute significantly to the final organoleptic properties, the ripening process, the shelf life, the safety and the overall quality of cheese. Methods: Ten commercial PDO feta cheeses from two geographic regions of Greece, Epirus and Thessaly, were analyzed by 16S metagenomic analysis. Results: The biodiversity of all the tested feta cheese samples consisted of five phyla, 17 families, 38 genera and 59 bacterial species. The dominant phylum identified was Firmicutes (49% of the species), followed by Proteobacteria (39% of the species), Bacteroidetes (7% of the species), Actinobacteria (4% of the species) and Tenericutes (1% of the species). Streptococcaceae and Lactobacillaceae were the most abundant families, in which starter cultures of lactic acid bacteria (LAB) belonged, but also 21 nonstarter lactic acid bacteria (NSLAB) were identified. Both geographical areas showed a distinctive microbiota fingerprint, which was ultimately overlapped by the application of starter cultures. In the rare biosphere of the feta cheese, Zobellella taiwanensis and Vibrio diazotrophicus, two Gram-negative bacteria which were not previously reported in dairy samples, were identified. Conclusions: The application of high-throughput DNA sequencing may provide a detailed microbial profile of commercial feta cheese produced with pasteurized milk.
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- 2021
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198. A Comparison of Three Methods for the Detection of Circulating Tumor Cells in Patients with Early and Metastatic Breast Cancer
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Eleni Politaki, Sofia Agelaki, Stella Apostolaki, Dora Hatzidaki, Areti Strati, Filippos Koinis, Maria Perraki, Georgia Saloustrou, Giannis Stoupis, Galatea Kallergi, Maria Spiliotaki, Tereza Skaltsi, Evi Lianidou, Vassilis Georgoulias, and Dimitrios Mavroudis
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Real Time RT-qPCR ,Circulating Tumor Cells ,Immunofluorescence ,Breast Cancer ,Cell Search System ,Physiology ,QP1-981 ,Biochemistry ,QD415-436 - Abstract
Background: We directly compared CTC detection rates and prognostic significance, using three different methods in patients with breast cancer (BC). Methods: Early (n=200) and metastatic (n=164) patients were evaluated before initiating adjuvant or first-line chemotherapy, using the CellSearchTM System, an RT-qPCR for CK-19 mRNA detection and by double immunofluorescence (IF) microscopy using A45-B/B3 and CD45 antibodies. Results: Using the CellSearchTM System, 37% and 16.5% of early BC patients were CTC-positive (at ≥1 and ≥2 CTCs/23 ml of blood), 18.0% by RT-qPCR and 16.9% by IF; no agreement was observed between methods. By the CellSearchTM 34.8% and 53.7% (at≥ 5 and ≥ 2 CTCs/7.5 ml) of metastatic patients were CTC-positive, 37.8% by RT-qPCR and 28.5% by IF. A significant agreement existed only between the CellSearchTM and RT-qPCR. In 60.8% of cases, differential EpCAM and CK-19 expression on CTCs by IF could explain the discrepancies between the CellSearchTM and RT-qPCR. CTC-positivity by either method was associated with decreased overall survival in metastatic patients. Conclusion: A significant concordance was observed between the CellSearchTM and RT-qPCR in metastatic but not in early BC. Discordant results could be explained in part by CTC heterogeneity. CTC detection by all methods evaluated had prognostic relevance in metastatic patients.
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- 2017
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199. PHASE 1B/2A STUDY OF AZD4573 (CDK9I) AND ACALABRUTINIB IN PATIENTS (PTS) WITH RELAPSED/REFRACTORY DIFFUSE LARGE B‐CELL LYMPHOMA (R/R DLBCL)
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Danilov, A., primary, Gregory, G. P., additional, Morschhauser, F., additional, Cheah, C. Y., additional, Shah, H., additional, Jurczak, W., additional, Olabode, D., additional, Meyer, S., additional, Yoon, J. L., additional, Arduini, S., additional, Saeh, J., additional, Olsson, R. F., additional, and Strati, P., additional
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- 2023
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200. SMART STOP: A PHASE II CLINICAL TRIAL OF LENALIDOMIDE, TAFASITAMAB, RITUXIMAB, AND ACALABRUTINIB ALONE AND WITH RESPONSE ADAPTED CHEMOTHERAPY IN PATIENTS WITH NEWLY DIAGNOSED DLBCL
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Westin, J., primary, Strati, P., additional, Chihara, D., additional, Pulsifer, B., additional, Tom, J., additional, Davis, R. E., additional, Lee, H. J., additional, Nair, R., additional, Rodriguez, A., additional, Hagemeister, F., additional, Flowers, C., additional, Nastoupil, L., additional, Feng, L., additional, Green, M., additional, Fayad, L., additional, Iyer, S., additional, Ahmed, S., additional, and Steiner, R., additional
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- 2023
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