151. Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum
- Author
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Yi Hong Tsai, Hsin Fu Yen, Chiao Ting Yen, Tsong-Long Hwang, Wan Jung He, Chia Lin Lee, Wei Yi Chang, Chao-Jung Chen, and Yang Chang Wu
- Subjects
Neutrophils ,Anti-Inflammatory Agents ,Plant Science ,Horticulture ,Solanum ,Biochemistry ,Inhibitory Concentration 50 ,chemistry.chemical_compound ,Superoxides ,Spirostans ,Humans ,Glycosides ,Solanum torvum ,Molecular Biology ,Yamogenin ,chemistry.chemical_classification ,Molecular Structure ,Pancreatic Elastase ,biology ,Plant Extracts ,Superoxide ,Pregnane ,Elastase ,Phytosterols ,Glycoside ,General Medicine ,Plant Components, Aerial ,Saponins ,Pregnanes ,biology.organism_classification ,In vitro ,chemistry ,Inflammation Mediators ,Solanaceae - Abstract
Torvpregnanosides A and B, two pregnane glycosides, and torvoside Q, a 23-keto-spirostanol glycoside, along with twelve known steroidal saponins were isolated from aerial parts of Solanum torvum. Of the latter, four of the 23-hydroxy-spirostanol glycosides, and, a yamogenin glycoside, were in this plant discovered. All structures were identified from spectroscopic data, and all the compounds were tested for in vitro anti-neutrophilic inflammatory activity. Two compounds showed selective inhibition against elastase release and superoxide anion generation, respectively, by human neutrophils with IC50 values of 5.66 and 3.59 μM, while two others inhibited both inflammatory mediators with IC50 values of 0.66-3.49 μM. Structure-activity relationships are discussed.
- Published
- 2013
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