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Background: Acute coronary syndrome (ACS) is witnessing a demographic transition with increasing prevalence among younger individuals (≤45 years). Hence, this study was designed to evaluate the clinical features, risk factors, and angiographic profile of young (aged ≤ 45 years) patients with ACS and to compare it with the older (aged >45 years) patients with ACS. Materials and Methods: An observational study was conducted at a tertiary care center in India from July 2020 to December 2021. A total of 157 patients were enrolled, among which 90 patients were included in cases (group-I). The inclusion criteria were patients presenting with ACS aged between 18 and 45 years. There were two control groups, including 34 patients with ACS (aged >45 years) in Group II and 33 healthy volunteers in Group III (aged 18--45 years). Baseline demographic details, risk factors, and angiographic profile of patients with ACS in each group were recorded and compared. Results: Mean age of Group I was 39.79 ± 5.15 years and of Group II was 59.74 ± 8.21 years. Smoking (P = 0.027) and family history of coronary artery disease (P = 0.022) were the significant risk factors of ACS in Group I. Compared to non-ST elevation myocardial infarction (16.7%), ST-elevation myocardial infarction (83.3%) was predominant among younger patients with ACS. Single-vessel disease was prevalent among younger patients (62.2%) as compared to older patients with ACS (41.20%). Conclusion: Younger patients with ACS exhibited a distinct clinical and angiographic profile compared to older patients with ACS. [ABSTRACT FROM AUTHOR]

Three different works combine to form a HF-3 dosage form, which is best on the basis of drug diffusion, in-vitro mucoadhesion and viscosity high solubility and, ease to use with adhesive nature over the skin, all three advantages are a must whenever we talk about the dermal formulation. The same happens with the drug amikacin, whose stability with minor solubility enhanced by the solid dispersion formation and encapsulated inside the vesicles called niosomes for sustained release and easy to adhere over the wound surface and finally, niosomes are encapsulated in hydrogels which provides the adhesive nature with easy to apply surety, at the same time it is able to provide a cooling sensation with surety to cure the wound. Also, drug and excipients have no interaction with each other and are quite stable in all dosage forms. Lastly all niosomal and hydrogel formulation compare with each other and proof that NF-8 as niosomal preparation and HF-3 as hydrogel preparation are overall best formulation and selected on the basis of many evaluation parameters. Finally one can conclude that whenever we select an oral route for targeting wound, there is a problem face by patient-related with improper amount of drug reached to the selected area and dose-related side effects and lastly patients non-compliance with tablet, for all this type of problems we can use the drug to be apply over the wound directly and for this prepared formulation NF-3 is best among all other formulation in case when we want to decrease dose frequency, directly applicable procedure and easy to use, and did not want any dose-related side effects as very less amount of drug used which is directly apply over wound and lastly slow or sustained drug release with almost whole drug penetrate from the wound which further help in heal the wound in less time duration. [ABSTRACT FROM AUTHOR]

Nanoparticle‐based polymeric carriers are highly desirable for efficient delivery of hydrophobic drugs. The development of nanocarriers with high encapsulation efficiency synthesized by a simple emulsification technique has become a challenging task with their controlled and sustained release ability at disease sites. Here, we have synthesized a series of hydrophobically modified hyaluronic–dodecylamide (HD) conjugates by coupling dodecylamine onto hyaluronic acid in varying amounts and characterized them using physicochemical techniques. The synthesized HD conjugates, in an aqueous medium, self‐assembled into nanoparticles of size in the range of ca 189–355 nm with hydrophilic surface and hydrophobic core. 6‐Thioguanine (TG) was used as a model drug for encapsulation into the hydrophobic core of the conjugate (HD‐2) by the standard emulsification technique with high encapsulation efficiency. Spectrophotometric analysis revealed that the drug‐loaded nanoconjugate showed a sustained release of drug over a period of time and also showed enzymatic responsiveness towards hyaluronidase. In vitro experiments were performed with HEK293, HeLa and HepG2 cells and it was observed that drug‐loaded nanoparticles were more toxic towards cancerous cells as compared with free TG. These results advocate that the reported system, being biocompatible, could be used as promising anticancer drug delivery system. © 2022 Society of Industrial Chemistry. [ABSTRACT FROM AUTHOR]

The research paper aims to explore the effects of violence on women's identity and mental health through a literary analysis of the works of Manjula Padmanabhan, Poile Sengupta, and Kishwar Desai. The purpose of this research is to investigate how these well-known female authors portray the effects of violence on the lives, sense of self, and psychological well-being of women in their written works. This study intends to contribute to a fuller understanding of the complicated relationship between violence, gender, and mental health by analyzing the authors' previous studies. In doing so, the authors hope to shed light on the particular difficulties women confront in societies plagued by violence. The results of this research have the potential to provide policymakers, mental health practitioners, and social advocates with information that can inform the development of tailored interventions to support women who have been harmed by violence. [ABSTRACT FROM AUTHOR]

Purpose: The study seeks to examine the influence of organisational justice on perceived organisational support among teachers in higher education institutions in the state of Uttarakhand. Methodology: The data was collected through a structured questionnaire, personal meetings, and Google Forms. A total of 400 faculty members participated in the study. The data was analysed with the help of Smart-PLS4. Findings: The study has revealed that all the three dimensions (distributive, procedural, and interactional) of organisational justice have a positive and significant influence on perceived organisational support. Research Limitations: We examined the effect of organisational justice only, and not the supervisor's support and job conditions, on the perceived organisational support of higher education teachers in the state of Uttarakhand. Policy Implications: The conclusions of the study are expected to help the management evolve new policies to develop the employees' positive attitudes towards the job by providing justice and support to their teachers. Originality/Value: Education has been one of the most critical parameters of development and is affected by the teachers' perception of organisational justice and support. So, it is essential to determine organisational justice's influence on the perceived organisational support. Several studies have been conducted on the impact of organisational justice on perceived organisational support in business firms, but no such study appears to have been conducted among the teachers of higher education institutions in the state of Uttarakhand. [ABSTRACT FROM AUTHOR]

Background and Aim: Several risk factors for the development of Cardiogenic shock (CS) have been identified - advanced age, prior history of MI, prior CABG, diabetes mellitus (DM), hypertension, anterior MI, left bundle branch block (LBBB) and multi-vessel disease. Present study was performed with following objectives: To study the clinical profile of patients with ACS complicated by cardiogenic shock, to assess the etiology of shock in patients presenting with STEMI and CS and to determine the clinical outcomes and in hospital mortality in Acute Coronary Syndrome (ACS) patients presenting with CS in a tertiary hospital. Material and Methods: This is a prospective observational study of 110 patients conducted at U. N. Mehta Institute of Cardiology and Research Centre, Ahmedabad, Gujarat, India. Patients with ACS and CS and giving written consent for the study were included. A detailed history was taken, a thorough physical examination was done and a detailed 2-D echocardiogram was done in all patients. Various Variable such as Age, sex, history of coronary risk factors, type of STEMI, presence of conduction abnormalities, end-organ hypoperfusion, systolic and diastolic BP, heart rate, LVEF (by echo), clinical signs of pulmonary congestion and evidence on CXR, CK MB, troponin positivity, baseline renal, presence or absence of anemia, procedural characteristics such as percutaneous coronary intervention, number of stents, TIMI flow, culprit-vessel or multivessel PCI, use of IABP were studied. Results: Chest pain or rest angina was the most common presenting symptom and was evident in 93 patients in STEMI group (95.9%) and eleven patients in NSTEMI group out of total thirteen patients. Conduction abnormality in the form of High grade AV block or Complete heart block was seen in sixteen (16.39%) patients of STEMI group with seven patients in anterior and nine inferior infarction. Mortality was seen in (41.53%) patients and major factor responsible was severe LV dysfunction and renal dysfunction. Out of 97 patients in STEMI group 55 (56.7%) patients were discharged and 42 (43.3%) patients died during hospital course. Conclusion: The mortality rates of patients with ACS have reduced significantly over the last few decades. The mortality rate in patients with cardiogenic shock was 43.63%. Survivors tended to be younger than patients who died. There was no difference in the cardiovascular risk factors amongst patients who survived or died. Advanced age, occurrence of ventricular tachycardia, high grade A-V block lack of revascularization, high total leukocyte counts and renal dysfunction were associated with increased risk of mortality. [ABSTRACT FROM AUTHOR]

Mutual funds have been the subject of inquiry and investigation by academics, researchers, and professionals in the field of finance. It is essential to the growth of the mutual fund industry that investors have a widespread readiness to accept mutual funds as a solid investment. Investors come from a wide range of socioeconomic backgrounds, and they also differ in terms of the rates of return they anticipate earning and the amount of risk they are ready to face. It is quite difficult to produce products that may fulfill the requirements of investors if one does not first determine the demographic and economic characteristics of these individuals. By analyzing the level of risk an investor is willing to take, one may infer the patterns of asset allocation they will use. When investing in mutual funds, it is essential to determine the factors and considerations that influence the investment decisions made by investors. The track records of mutual fund schemes are formed via the use of periodical performance evaluations. These reviews also act as an aggressive marketing technique for the purpose of obtaining cash from individual investors. The following are the objectives of the study to study the perception of the investors towards the mutual fund and to analyze the investors' behaviour towards mutual funds. The study is qualitative in nature carried out in during the month of August 2022. To understand the investors' perception towards the mutual funds, 250 sample respondents having investment in the mutual funds are purposively selected. The information is collected through Google forms and analyzed with the help of SPSS. [ABSTRACT FROM AUTHOR]