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1,271 results on '"Singh, Nina"'

155. Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality

Author

Singh, Nina, Alexander, Barbara D., Lortholary, Olivier, Dromer, Francoise, Gupta, Krishan L., John, George T., del Busto, Ramon, Klintmalm, Goran B., Somani, Jyoti, Lyon, G. Marshall, Pursell, Kenneth, Stosor, Valentina, Munoz, Patricia, Limaye, Ajit P., Kalil, Andre C., Pruett, Timothy L., Garcia-Diaz, Julia, Humar, Atul, Houston, Sally, House, Andrew A., Wray, Danah, Orloff, Susan, Dowdy, Lorraine A., Fisher, Robert A., Heitman, Joseph, Wagener, Marilyn M., and Husain, Shahid

Subjects
Cryptococcal infections -- Risk factors, Cryptococcal infections -- Research, Organ transplant recipients -- Research, Calcineurin -- Research, Health
Published
2007

163. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium

Author

Cornely, Oliver A., Alastruey-Izquierdo, Ana, Arenz, Dorothee, Chen, Sharon C. A., Dannaoui, Eric, Hochhegger, Bruno, Hoenigl, Martin, Jensen, Henrik E., Lagrou, Katrien, Lewis, Russell E., Mellinghoff, Sibylle C., Mer, Mervyn, Pana, Zoi D., Seidel, Danila, Sheppard, Donald C., Wahba, Roger, Akova, Murat, Alanio, Alexandre, Al-Hatmi, Abdullah M. S., Arikan-Akdagli, Sevtap, Badali, Hamid, Ben-Ami, Ronen, Bonifaz, Alexandro, Bretagne, Stephane, Castagnola, Elio, Chayakulkeeree, Methee, Colombo, Arnaldo L., Corzo-Leon, Dora E., Drgona, Lubos, Groll, Andreas H., Guinea, Jesus, Heussel, Claus-Peter, Ibrahim, Ashraf S., Kanj, Souha S., Klimko, Nikolay, Lackner, Michaela, Lamoth, Frederic, Lanternier, Fanny, Lass-Floerl, Cornelia, Lee, Dong-Gun, Lehrnbecher, Thomas, Lmimouni, Badre E., Mares, Mihai, Maschmeyer, Georg, Meis, Jacques F., Meletiadis, Joseph, Morrissey, C. Orla, Nucci, Marcio, Oladele, Rita, Pagano, Livio, Pasqualotto, Alessandro, Patel, Atul, Racil, Zdenek, Richardson, Malcolm, Roilides, Emmanuel, Ruhnke, Markus, Seyedmousavi, Seyedmojtaba, Sidharthan, Neeraj, Singh, Nina, Sinko, Janos, Skiada, Anna, Slavin, Monica, Soman, Rajeev, Spellberg, Brad, Steinbach, William, Tan, Ban Hock, Ullmann, Andrew J., Vehreschild, Joerg J., Vehreschild, Maria J. G. T., Walsh, Thomas J., White, P. Lewis, Wiederhold, Nathan P., Zaoutis, Theoklis, Chakrabarti, Arunaloke, Cornely, Oliver A., Alastruey-Izquierdo, Ana, Arenz, Dorothee, Chen, Sharon C. A., Dannaoui, Eric, Hochhegger, Bruno, Hoenigl, Martin, Jensen, Henrik E., Lagrou, Katrien, Lewis, Russell E., Mellinghoff, Sibylle C., Mer, Mervyn, Pana, Zoi D., Seidel, Danila, Sheppard, Donald C., Wahba, Roger, Akova, Murat, Alanio, Alexandre, Al-Hatmi, Abdullah M. S., Arikan-Akdagli, Sevtap, Badali, Hamid, Ben-Ami, Ronen, Bonifaz, Alexandro, Bretagne, Stephane, Castagnola, Elio, Chayakulkeeree, Methee, Colombo, Arnaldo L., Corzo-Leon, Dora E., Drgona, Lubos, Groll, Andreas H., Guinea, Jesus, Heussel, Claus-Peter, Ibrahim, Ashraf S., Kanj, Souha S., Klimko, Nikolay, Lackner, Michaela, Lamoth, Frederic, Lanternier, Fanny, Lass-Floerl, Cornelia, Lee, Dong-Gun, Lehrnbecher, Thomas, Lmimouni, Badre E., Mares, Mihai, Maschmeyer, Georg, Meis, Jacques F., Meletiadis, Joseph, Morrissey, C. Orla, Nucci, Marcio, Oladele, Rita, Pagano, Livio, Pasqualotto, Alessandro, Patel, Atul, Racil, Zdenek, Richardson, Malcolm, Roilides, Emmanuel, Ruhnke, Markus, Seyedmousavi, Seyedmojtaba, Sidharthan, Neeraj, Singh, Nina, Sinko, Janos, Skiada, Anna, Slavin, Monica, Soman, Rajeev, Spellberg, Brad, Steinbach, William, Tan, Ban Hock, Ullmann, Andrew J., Vehreschild, Joerg J., Vehreschild, Maria J. G. T., Walsh, Thomas J., White, P. Lewis, Wiederhold, Nathan P., Zaoutis, Theoklis, and Chakrabarti, Arunaloke

Abstract

Mucormycosis is a difficult to diagnose rare disease with high morbidity and mortality. Diagnosis is often delayed, and disease tends to progress rapidly. Urgent surgical and medical intervention is lifesaving. Guidance on the complex multidisciplinary management has potential to improve prognosis, but approaches differ between health-care settings. From January, 2018, authors from 33 countries in all United Nations regions analysed the published evidence on mucormycosis management and provided consensus recommendations addressing differences between the regions of the world as part of the One World One Guideline initiative of the European Confederation of Medical Mycology (ECMM). Diagnostic management does not differ greatly between world regions. Upon suspicion of mucormycosis appropriate imaging is strongly recommended to document extent of disease and is followed by strongly recommended surgical intervention. First-line treatment with high-dose liposomal amphotericin B is strongly recommended, while intravenous isavuconazole and intravenous or delayed release tablet posaconazole are recommended with moderate strength. Both triazoles are strongly recommended salvage treatments. Amphotericin B deoxycholate is recommended against, because of substantial toxicity, but may be the only option in resource limited settings. Management of mucormycosis depends on recognising disease patterns and on early diagnosis. Limited availability of contemporary treatments burdens patients in low and middle income settings. Areas of uncertainty were identified and future research directions specified.

Published
2019

165. Cryptococcus neoformans infection in patients with cirrhosis, including liver transplant candidates

Author

Singh, Nina, Husain, Shahid, de Vera, Michael, Gayowski, Timothy, and Cacciarelli, Thomas V.

Subjects
Liver cirrhosis -- Causes of, Liver cirrhosis -- Comparative analysis, Liver cirrhosis -- Care and treatment, Cryptococcus -- Influence, Cryptococcus -- Research, Cryptococcal infections -- Risk factors, Cryptococcal infections -- Comparative analysis, Cryptococcal infections -- Care and treatment
Published
2004

183. MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold

Author

Oreskovich, Stephan M, primary, Ong, Frank J, additional, Ahmed, Basma A, additional, Konyer, Norman B, additional, Blondin, Denis P, additional, Gunn, Elizabeth, additional, Singh, Nina P, additional, Noseworthy, Michael D, additional, Haman, Francois, additional, Carpentier, Andre C, additional, Punthakee, Zubin, additional, Steinberg, Gregory R, additional, and Morrison, Katherine M, additional

Published
2019
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186. LB21. Preemptive Therapy (PET) vs. Prophylaxis for Prevention of Cytomegalovirus (CMV) Disease in High-Risk Donor Seropositive/Recipient Seronegative (D+R−) Liver Transplant Recipients (LTR): A NIH-Sponsored, Randomized, Controlled, Multicenter Trial

Author

Singh, Nina, primary, Winston, Drew, additional, Razonable, Raymund R, additional, Lyon III, G Marshall, additional, Silveira, Fernanda P, additional, Wagener, Marilyn, additional, and Limaye, Ajit P, additional

Published
2018
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199. Pulmonary nodules in liver transplant recipients

Author

Paterson, David L., Singh, Nina, Gayowski, Timothy, and Marino, Ignazio R.

Subjects
Lung diseases -- Health aspects, Liver -- Transplantation, Postoperative period -- Health aspects, Lungs
Published
1998

200. Risk Factors for Cytomegalovirus Viremia following Liver Transplantation With a Seropositive Donor and Seronegative Recipient Receiving Antiviral Therapy.

Author

Singh, Nina, Winston, Drew J, Razonable, Raymund R, Lyon, G Marshall, Silveira, Fernanda P, Wagener, Marilyn M, and Limaye, Ajit P

Subjects
*LIVER transplantation, *CLINICAL trial registries, *VIREMIA, *CYTOMEGALOVIRUSES, *BK virus, *POLYMERASE chain reaction
Abstract

Background: The risk factors for development of viremia in high-risk donor cytomegalovirus (CMV)-seropositive and recipient CMV-seronegative (D+R-) transplant recipients are incompletely defined.Methods: The study population comprised patients in the preemptive therapy (PET) arm of a randomized, controlled trial of PET versus prophylaxis using valganciclovir in D+R- liver transplant recipients. Weekly surveillance monitoring for viremia for 100 days was performed using a sensitive CMV-DNA polymerase chain reaction assays. Risk factors for viremia and time to onset (≤4 vs >4 weeks) of viremia were examined using logistic regression models.Results: Viremia developed in 84% (79/94) of recipients and older donor age was the only independent factor associated with viremia (odds ratio, 2.20 for each quartile increase in donor age; 95% confidence interval [CI], 1.07-4.52; P = .031). Recipients who developed early-onset viremia (within 4 weeks) also had significantly older donors than those with later-onset viremia (difference in age 10.1 years; 95% CI, 2-19; P = .03).Conclusions: Older donor age was an independent predictor of viremia and earlier-onset of viremia in D+R- liver transplant recipients. Future studies should assess the mechanistic links underlying this novel association.Clinical Trial Registration: NCT01552369. [ABSTRACT FROM AUTHOR]

Published
2021
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