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158. The impact of the COVID‐19 pandemic on patients with chronic liver disease: Results from the Global Liver Registry

Author

Younossi, Zobair M., primary, Yilmaz, Yusuf, additional, El‐Kassas, Mohamed, additional, Duseja, Ajay, additional, Hamid, Saeed, additional, Esmat, Gamal, additional, Méndez‐Sánchez, Nahum, additional, Chan, Wah Kheong, additional, Singal, Ashwani K., additional, Lam, Brian, additional, Felix, Sean, additional, Younossi, Elena, additional, Verma, Manisha, additional, Price, Jillian K., additional, Nader, Fatema, additional, Younossi, Issah, additional, Racila, Andrei, additional, and Stepanova, Maria, additional

Published
2022
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160. Negative impact of COVID-19 infection related to life disruption events and health scores on patients with chronic liver disease

Author

Younossi, Zobair, primary, Yılmaz, Yusuf, additional, El Kassas, Mohamed, additional, Duseja, Ajay Kumar, additional, Hamid, Saeed Sadiq, additional, Esmat, Gamal, additional, Méndez-Sánchez, Nahum, additional, Chan, Wah-Kheong, additional, Singal, Ashwani, additional, Ong, Janus, additional, Lam, Brian, additional, Felix, Sean, additional, Younossi, Elena, additional, Verma, Manisha, additional, Price, Jillian, additional, Nader, Fatema, additional, Younossi, Issah, additional, Racila, Andrei, additional, and Stepanova, Maria, additional

Published
2022
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161. Lean non-alcoholic fatty liver disease patients from the global NASH registry

Author

Younossi, Zobair, primary, Yılmaz, Yusuf, additional, Yu, Ming-Lung, additional, Wong, Vincent Wai-Sun, additional, Castellanos-Fernandez, Marlen, additional, Isakov, Vasily, additional, Duseja, Ajay Kumar, additional, Méndez-Sánchez, Nahum, additional, Eguchi, Yuichiro, additional, Bugianesi, Elisabetta, additional, Burra, Patrizia, additional, George, Jacob, additional, Fan, Jian-Gao, additional, Papatheodoridis, George, additional, Chan, Wah-Kheong, additional, Alswat, Khalid, additional, Hamid, Saeed Sadiq, additional, Singal, Ashwani, additional, Gomez, Manuel Romero, additional, Gordon, Stuart C, additional, Roberts, Stuart, additional, El Kassas, Mohamed, additional, Kugelmas, Marcelo, additional, Ong, Janus, additional, Alqahtani, Saleh, additional, Ziayee, Mariam, additional, Lam, Brian, additional, Younossi, Issah, additional, Racila, Andrei, additional, Henry, Linda, additional, and Stepanova, Maria, additional

Published
2022
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162. The number of public health policies reduces the burden and mortality of alcohol-associated liver disease worldwide: a call for action

Author

Diaz, Luis Antonio, primary, Fuentes, Eduardo, additional, Idalsoaga, Francisco, additional, Arnold, Jorge, additional, Ayares, Gustavo, additional, Cannistra, Macarena, additional, Vio, Danae, additional, Márquez, Andrea, additional, Corsi, Oscar, additional, Villalón, Alejandro, additional, Ramirez, Carolina, additional, Medel, María Paz, additional, Ferreccio, Catterina, additional, Lazo, Mariana, additional, Roblero, Juan Pablo, additional, Kulkarni, Anand, additional, Kim, Won, additional, Brahmania, Mayur, additional, Louvet, Alexandre, additional, Tapper, Elliot, additional, Dunn, Winston, additional, Simonetto, Douglas, additional, Shah, Vijay, additional, Kamath, Patrick S., additional, Singal, Ashwani, additional, Bataller, Ramon, additional, Arrese, Marco, additional, and Arab, Juan Pablo, additional

Published
2022
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164. Alcohol associated hepatitis in Latin America: results from the AH-LATIN study

Author

Arnold, Jorge, primary, Diaz, Luis Antonio, additional, Idalsoaga, Francisco, additional, Ayares, Gustavo, additional, Fuentes, Eduardo, additional, Ramirez, Carolina, additional, Medel, María Paz, additional, Ferreccio, Catterina, additional, Lazo, Mariana, additional, Roblero, Juan Pablo, additional, Brahmania, Mayur, additional, Carbonetti, Rodolfo, additional, Marciano, Sebastián, additional, Mendizabal, Manuel, additional, Bessone, Fernando, additional, Romero, Gustavo, additional, Palazzo, Ana, additional, Manero, Estela Florencia, additional, Dirchwolf, Melisa, additional, Piombino, Diego, additional, Valverde, María Ayala, additional, Cairo, Fernando, additional, Gracia Villamil, Maria Alejandra, additional, Rodriguez Gazari, Maria Mercedes, additional, Gallardo, Patricia, additional, Ramos, Geraldine, additional, Guerra, Patricia, additional, Silveira, Fabio, additional, Chaves, Roberta, additional, Silva, Giovanni, additional, Lobato, Cirley, additional, Lemos, Jozelda, additional, Alves, Rogério, additional, Pereira, Gustavo, additional, de Cássia Martins Alves da Silva, Rita, additional, Costa Mendes, Liliana Sampaio, additional, Couto, Cláudia Alves, additional, Rocha, Cristina Melo, additional, Lazarte, Raul, additional, Yaquich, Pamela, additional, Norero, Blanca, additional, Jure, Camila, additional, Dominguez, Alejandra, additional, Vicar, Marta Mac, additional, Rivas, Violeta, additional, Arancibia, Juan Pablo, additional, Sierralta, Armando, additional, Valera, Jose, additional, Diaz, Sebastian, additional, Sanchez, Carlos, additional, Toro, Luis, additional, Varon, Adrian, additional, Correa, Elizabeth, additional, Restrepo, Juan Carlos, additional, Tapias, Monica, additional, Rosales, Ricardo Aguilera, additional, Infante, Mirtha, additional, Pazmiño, Galo, additional, Armijos, Xiimena, additional, Carrera, Enrique, additional, Ligoria, Regina, additional, Avila, Gerson, additional, Sanchez, Abel, additional, Sánchez, Marco, additional, Mejia, Scherezada, additional, Cordova, Jacqueline, additional, De Fatima Higuera de La Tijera, Maria, additional, Contreras, Raul, additional, Solis, Francisco, additional, Varela, Jesus, additional, Jacobo, Janett, additional, Velarde-Ruiz Velasco, Jose Antonio, additional, Quezada, Julissa Lombardo, additional, Veramendi, Esther, additional, Vela, Victor, additional, Pamo, Claudia, additional, Puma, Donny, additional, Marcelo, Julio, additional, Tenorio, Laura, additional, Cabrera, Maria, additional, Rivera, Jose, additional, Montes, Pedro, additional, Bataller, Ramon, additional, Louvet, Alexandre, additional, Shah, Vijay, additional, Kamath, Patrick S., additional, Singal, Ashwani, additional, Arrese, Marco, additional, and Arab, Juan Pablo, additional

Published
2022
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173. Response to comments on 'Changing landscape of alcohol‐associated liver disease in younger individuals, women and ethnic minorities'.

Author

Arab, Juan P., Dunn, Winston, Im, Gene, and Singal, Ashwani K.

Subjects
BLOOD alcohol, ALCOHOL drinking, GENDER role, HEALTH policy, LIVER diseases
Abstract

This document is a response to comments on an article titled "Changing landscape of alcohol-associated liver disease in younger individuals, women, and ethnic minorities." The authors thank Dr. Chong-Chi Chiu and colleagues for their comments and agree with their observations on the evolving patterns of alcohol consumption among women. They acknowledge the need for targeted prevention and treatment strategies that address the unique vulnerabilities of female drinkers, including physiological differences and hormonal factors. The authors also emphasize the role of cultural dynamics and call for more research to understand specific risk factors and protective measures for women. They express their commitment to continuing research in this area to develop effective strategies for reducing the burden of alcohol-associated liver disease among high-risk populations, including women. [Extracted from the article]

Published
2024
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179. Prevalence and factors affecting occurrence of type 2 diabetes mellitus in Saudi patients with chronic liver disease

Author

Singal Ashwani and Ayoola Ayobanji

Subjects
Cirrhosis, diabetes mellitus, hepatocellular carcinoma, Saudi Arabia, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Background/Aim: Type 2 diabetes mellitus (DM-2) is more common in patients with chronic liver disease (CLD) in general and chronic hepatitis C virus (HCV) infection in particular. We aimed to determine the prevalence and factors affecting the occurrence of DM-2 in Saudi patients with CLD. Materials and Methods: Retrospective study at the King Fahd Central Hospital (KFCH), Gizan, Saudi Arabia. A total of 277 patients with either cirrhosis (CH) or hepatocellular carcinoma (HCC) were analyzed for patient demographics, severity of liver disease, HBsAg, and anti-HCV, associated diseases including DM-2, and presence of HCC. The prevalence of DM-2 was also estimated in 400 age- and sex-matched Saudi patients admitted for various nonliver diseases (control group). Chi-square test, univariate analysis, and multivariate regression. Results: Prevalence of DM-2 in patients with CH was higher than in controls (19.2 vs. 9.2%; P = 0.001). Although those with HCC had a higher prevalence, the difference was not significant (10.9 vs. 9.2%; P = 0.5). Seventy-six percent of patients with HCC had associated CH. On multivariate analysis, age and hypertension were more common in diabetics. Although patients with HCV-related disease had a higher prevalence of DM-2 compared to HBV-related disease, the difference was not significant (26.3 vs. 15.7%; P > 0.05). Conclusions: DM-2 occurred more frequently in CLD patients, particularly in cirrhotics. Age and hypertension predicted the occurrence of DM-2. Small sample size of patients with HCV-related CH probably precluded higher prevalence of DM-2 in them.

Published
2008

183. Simultaneous Management of Alcohol Use Disorder and Liver Disease: A Systematic Review and Meta-analysis.

Author

Elfeki, Mohamed A., Abdallah, Mohamed A., Leggio, Lorenzo, and Singal, Ashwani K.

Abstract

Objectives: Management of alcohol use disorder (AUD) is rarely used in patients with liver disease. We performed a systematic review to examine the impact of AUD management among patients with liver disease. Methods: Twenty studies fulfilling the inclusion and exclusion criteria on 38,329 patients (7072 receiving AUD intervention) with liver disease (15 with liver disease and 6 liver transplant [LT] recipients) were analyzed. One study was common to both groups. Variable follow-up period across studies was weighted for sample size and converting to person-years. Primary outcome was alcohol use, and secondary outcomes were liver decompensation and patient mortality. Results: Abstinence and alcohol relapse rates/person-year with AUD intervention among liver disease patients were 0.41 (0.27–0.55) and 0.42 (0.30–0.755), similar for integrated (colocated liver and addiction clinics) versus concomitant (separate hepatology and addiction clinics) intervention. Compared with standard of care, odds for decompensation with AUD intervention (n = 1), 30-day readmission (n = 1), and patient mortality (n = 2) were lower by 44%, 59%, and 58% respectively. Similar figures were 1.24 (0.86–1.80) for abstinence and 0.52 (0.24–0.14) for relapse. Among LT recipients, odds for alcohol relapse and mortality with follow-up integrated with addiction team versus hepatology alone were 0.48 (0.25–0.72) and 0.29 (0.08–0.99), respectively. Conclusions: Follow-up of LT recipients in an integrated clinic with addiction team is associated with improved outcomes. Simultaneous management of AUD in patients with liver disease improves liver-related outcomes. Large prospective studies are needed to examine benefits of AUD intervention in patients with liver disease. [ABSTRACT FROM AUTHOR]

Published
2023
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184. Therapeutic Pipeline in Alcohol-Associated Liver Disease.

Author

Thakral, Nimish, Deutsch-Link, Sasha, and Singal, Ashwani K.

Subjects
ALCOHOLISM, LIVER diseases, TEMPERANCE, ALCOHOL drinking, LIVER transplantation
Abstract

Alcohol-associated liver disease is a leading cause of mortality and morbidity worldwide. Patients with alcohol-associated liver disease are often diagnosed at advanced stage and disease spectrum including alcoholic hepatitis, a severe manifestation with a high short-term mortality. Corticosteroid, recommended first-line treatment for patients with alcoholic hepatitis, is a very suboptimal treatment. Although the use of early liver transplantation has increased with consistent benefit in select patients with alcoholic hepatitis, its use remains heterogeneous worldwide due to lack of uniform selection criteria. Over the last decade, several therapeutic targets have evolved of promise with ongoing clinical trials in patients with cirrhosis and alcoholic hepatitis. Even with availability of effective medical therapies for alcohol-associated liver disease, long-term outcome depends on abstinence from alcohol use in any spectrum of alcohol-associated liver disease. However, alcohol use disorder treatment remains underutilized due to several barriers even in patients with advanced disease. There is an urgent unmet need to implement and promote integrated multidisciplinary care model with hepatologists and addiction experts to provide comprehensive management for these patients. In this review, we will discuss newer therapies targeting liver disease and therapies targeting alcohol use disorder in patients with alcohol-associated liver disease. [ABSTRACT FROM AUTHOR]

Published
2023
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186. P-30 IMPACT OF PUBLIC HEALTH POLICIES ON ALCOHOL-ASSOCIATED LIVER DISEASE IN LATIN AMERICA: AN ECOLOGICAL MULTI-NATIONAL STUDY

Author

Díaz Luis, Antonio, Idalsoaga, Francisco, Fuentes-López, Eduardo, Márquez, Andrea, A. Ramírez, Carolina, Roblero, Juan Pablo, C., Araujo Roberta, Higuera – de – la – tijera, Fátima, Toro, Luis Guillermo, Pazmiño, Galo, Montes, Pedro, Hernandez, Nelia, Mendizabal, Manuel, Corsi, Oscar, Ferreccio, Catterina, Lazo, Mariana, Brahmania, Mayur, Singal, Ashwani K., Bataller, Ramon, Arrese, Marco, and Arab, Juan Pablo

Published
2021
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192. Research methodologies to address clinical unmet needs and challenges in alcohol‐associated liver disease

Author

Singal, Ashwani K., primary, Kwo, Paul, additional, Kwong, Allison, additional, Liangpunsakul, Suthat, additional, Louvet, Alexandre, additional, Mandrekar, Pranoti, additional, McClain, Craig, additional, Mellinger, Jessica, additional, Szabo, Gyongyi, additional, Terrault, Norah, additional, Thursz, Mark, additional, Winder, Gerald S., additional, Kim, W. Ray, additional, and Shah, Vijay H., additional

Published
2021
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