151. Effect of sub-lethal doses of Bacillus thuringiensis subsp. Aizawai and deltamethrin with regard to fertility and organ toxicity in pregnant albino rats.
- Author
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Lemos AJ, Siqueira HA, Wanderley-Teixeira V, Maia FC, Teixeira ÁA, Silva EJ, and Oliveira JV
- Subjects
- Animals, Dose-Response Relationship, Drug, Female, Kidney pathology, Liver pathology, Lung pathology, Organ Specificity, Pregnancy, Rats, Rats, Wistar, Bacterial Toxins toxicity, Fertility drug effects, Insecticides toxicity, Kidney drug effects, Liver drug effects, Lung drug effects, Nitriles toxicity, Protein Precursors toxicity, Pyrethrins toxicity
- Abstract
Products with Bacillus thuringiensis (Bt) and synthetic insecticides have been widely used against important vectors of human diseases. However, few studies have addressed the application of these substances on the female reproduction apparatus during pregnancy at doses that do not cause clinical symptoms of intoxication. Seventy pregnant albino rats were analyzed with regard to fertility and histopathology of the kidneys, liver and lungs as well as the morphology of the neonates. The rats were submitted to three sub-lethal doses of the biological insecticide XenTari(®) WG (B. thuringiensis subsp. Aizawai) and the synthetic insecticide deltamethrin (Decis(®) 25CE). After the confirmation of copulation, the insecticides were administered orally for either seven days or during the entire pregnancy. The analysis revealed histopathological alterations in all organs analyzed in both treatments. No miscarriages occurred and the neonates did not exhibit signs of malformation of the head, limbs, thorax or abdomen. However, there were a smaller number of pups in the groups that received higher doses of the insecticides in comparison to the control group. Both insecticides produced similar lesions in the kidneys, liver and lungs and reduced the fertility of rats when administered at sub-lethal doses with no clinical signs of intoxication. Thus, this study suggests that sublethal doses of both insecticides can provide chronic toxicity in humans., (Copyright © 2012 Elsevier GmbH. All rights reserved.)
- Published
- 2013
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