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154. The monoids of the patience sorting algorithm

Author

Cain, Alan J., Malheiro, António, and Silva, Fábio M.

Subjects
Mathematics - Group Theory, Mathematics - Combinatorics, 20M05 (Primary), 68Q45, 05E05, 05A05, 05A19, 11Y16 (Secondary)
Abstract

The left patience sorting (lPS) monoid, also known in the literature as the Bell monoid, and the right patient sorting (rPS) monoid are introduced by defining certain congruences on words. Such congruences are constructed using insertion algorithms based on the concept of decreasing subsequences. Presentations for these monoids are given. Each finite-rank rPS monoid is shown to have polynomial growth and to satisfy a non-trivial identity (dependent on its rank), while the infinite rank rPS monoid does not satisfy a non-trivial identity. The lPS monoids of finite rank have exponential growth and thus do not satisfy non-trivial identities. The complexity of the insertion algorithms is discussed. rPS monoids of finite rank are shown to be automatic and to have recursive complete presentations. When the rank is $1$ or $2$, they are also biautomatic. lPS monoids of finite rank are shown to have finite complete presentations and to be biautomatic., Comment: 42 pages

Published
2017

155. Impact of intravascular hemolysis on functional and molecular alterations in the urinary bladder: implications for an overactive bladder in sickle cell disease.

Author

Rebecchi e Silveira, Tammyris Helena, Andrade Pereira, Dalila, Andrade Pereira, Danillo, Beraldi Calmasini, Fabiano, Burnett, Arthur L., Ferreira Costa, Fernando, and Henrique Silva, Fábio

Subjects
CYCLIC guanylic acid, OVERACTIVE bladder, SICKLE cell anemia, NITRIC-oxide synthases, NADPH oxidase
Abstract

Patients with sickle cell disease (SCD) display an overactive bladder (OAB). Intravascular hemolysis in SCD is associated with various severe SCD complications. However, no experimental studies have evaluated the effect of intravascular hemolysis on bladder function. This study aimed to assess the effects of intravascular hemolysis on the micturition process and the contractile mechanisms of the detrusor smooth muscle (DSM) in a mouse model with phenylhydrazine (PHZ)-induced hemolysis; furthermore, it aimed to investigate the role of intravascular hemolysis in the dysfunction of nitric oxide (NO) signaling and in increasing oxidative stress in the bladder. Mice underwent a void spot assay, and DSM contractions were evaluated in organ baths. The PHZ group exhibited increased urinary frequency and increased void volumes. DSM contractile responses to carbachol, KCl, a-ß-methylene-ATP, and EFS were increased in the PHZ group. Protein expression of phosphorylated endothelial NO synthase (eNOS) (Ser-1177), phosphorylated neuronal NO synthase (nNOS) (Ser-1417), and phosphorylated vasodilator-stimulated phosphoprotein (VASP) (Ser-239) decreased in the bladder of the PHZ group. Protein expression of oxidative stress markers, NOX-2, 3-NT, and 4-HNE, increased in the bladder of the PHZ group. Our study shows that intravascular hemolysis promotes voiding dysfunction correlated with alterations in the NO signaling pathway in the bladder, as evidenced by reduced levels of p-eNOS (Ser-1177), nNOS (Ser-1417), and p-VASP (Ser-239). The study also showed that intravascular hemolysis increases oxidative stress in the bladder. Our study indicates that intravascular hemolysis promotes an OAB phenotype similar to those observed in patients and mice with SCD. [ABSTRACT FROM AUTHOR]

Published
2024
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156. Targeting heme in sickle cell disease: new perspectives on priapism treatment.

Author

Silveira, Tammyris Helena Rebecchi, Beraldi Calmasini, Fabiano, Gonçalves de Oliveira, Mariana, Ferreira Costa, Fernando, and Henrique Silva, Fábio

Subjects
CYCLIC guanylic acid, SICKLE cell anemia, SEXUAL excitement, HEME oxygenase, PRIAPISM
Abstract

Men with sickle cell disease (SCD) frequently experience priapism, defined as prolonged, painful erections occurring without sexual arousal or desire. This urological emergency can lead to penile fibrosis and permanent erectile dysfunction if not treated adequately. Due to its complex pathophysiology, there is currently no effective preventative treatment for this condition. Recent studies have highlighted the dysfunction of the nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) pathway in erectile tissues as a critical mechanism in developing priapism in SCD. Additionally, further research indicates that intravascular hemolysis promotes increased smooth muscle relaxation in the corpus cavernosum and that excess heme may significantly contribute to priapism in SCD. Pharmacological treatments should ideally target the pathophysiological basis of the disease. Agents that reduce excess free heme in the plasma have emerged as potential therapeutic candidates. This review explores the molecular mechanisms underlying the excess of heme in SCD and its contribution to developing priapism. We discuss pharmacological approaches targeting the excess free heme in the plasma, highlighting it as a potential therapeutic target for future interventions in managing priapism. [ABSTRACT FROM AUTHOR]

Published
2024
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157. Sequencing and Description of the Mitochondrial Genome of Orthopodomyia fascipes (Diptera: Culicidae).

Author

Silva, Fábio Silva da, Nascimento, Bruna Laís Sena do, Cruz, Ana Cecília Ribeiro, Silva, Sandro Patroca da, Aragão, Carine Fortes, Dias, Daniel Damous, Silva, Lucas Henrique da Silva e, Reis, Lúcia Aline Moura, Reis, Hanna Carolina Farias, Chagas, Liliane Leal das, Rosa Jr., José Wilson, Vieira, Durval Bertram Rodrigues, Brandão, Roberto Carlos Feitosa, Medeiros, Daniele Barbosa de Almeida, and Nunes Neto, Joaquim Pinto

Subjects
*MITOCHONDRIAL DNA, *NUCLEOTIDE sequencing, *BAYESIAN field theory, *DIPTERA, *PHYLOGENY
Abstract

The genus Orthopodomyia Theobald, 1904 (Diptera: Culicidae) comprises 36 wild mosquito species, with distribution largely restricted to tropical and temperate areas, most of which are not recognized as vectors of epidemiological importance due to the lack of information related to their bionomy and involvement in the cycle transmission of infectious agents. Furthermore, their evolutionary relationships are not completely understood, reflecting the scarcity of genetic information about the genus. Therefore, in this study, we report the first complete description of the mitochondrial genome of a Neotropical species representing the genus, Orthopodomyia fascipes Coquillet, 1906, collected in the Brazilian Amazon region. Using High Throughput Sequencing, we obtained a mitochondrial sequence of 15,598 bp, with an average coverage of 418.5×, comprising 37 functional subunits and a final portion rich in A + T, corresponding to the control region. The phylogenetic analysis, using Maximum Likelihood and Bayesian Inference based on the 13 protein-coding genes, corroborated the monophyly of Culicidae and its two subfamilies, supporting the proximity between the tribes Orthopodomyiini and Mansoniini, partially disagreeing with previous studies based on the use of molecular and morphological markers. The information generated in this study contributes to a better understanding of the taxonomy and evolutionary history of the genus and other groups of Culicidae. [ABSTRACT FROM AUTHOR]

Published
2024
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158. The Pattern of GH Action in the Mouse Brain.

Author

Menezes, Filipe, Wasinski, Frederick, Souza, Gabriel O de, Nunes, Amanda P, Bernardes, Emerson S, Santos, Sofia N dos, Silva, Fábio F A da, Peroni, Cibele N, Oliveira, João E, Kopchick, John J, Brown, Rosemary S E, Fernandez, Gimena, Francesco, Pablo N De, Perelló, Mario, Soares, Carlos R J, and Donato, Jose

Subjects
SINGLE-photon emission computed tomography, CELIAC artery, CHOROID plexus, PREOPTIC area, MICE
Abstract

GH acts in numerous organs expressing the GH receptor (GHR), including the brain. However, the mechanisms behind the brain's permeability to GH and how this hormone accesses different brain regions remain unclear. It is well-known that an acute GH administration induces phosphorylation of the signal transducer and activator of transcription 5 (pSTAT5) in the mouse brain. Thus, the pattern of pSTAT5 immunoreactive cells was analyzed at different time points after IP or intracerebroventricular GH injections. After a systemic GH injection, the first cells expressing pSTAT5 were those near circumventricular organs, such as arcuate nucleus neurons adjacent to the median eminence. Both systemic and central GH injections induced a medial-to-lateral pattern of pSTAT5 immunoreactivity over time because GH-responsive cells were initially observed in periventricular areas and were progressively detected in lateral brain structures. Very few choroid plexus cells exhibited GH-induced pSTAT5. Additionally, Ghr mRNA was poorly expressed in the mouse choroid plexus. In contrast, some tanycytes lining the floor of the third ventricle expressed Ghr mRNA and exhibited GH-induced pSTAT5. The transport of radiolabeled GH into the hypothalamus did not differ between wild-type and dwarf Ghr knockout mice, indicating that GH transport into the mouse brain is GHR independent. Also, single-photon emission computed tomography confirmed that radiolabeled GH rapidly reaches the ventral part of the tuberal hypothalamus. In conclusion, our study provides novel and valuable information about the pattern and mechanisms behind GH transport into the mouse brain. [ABSTRACT FROM AUTHOR]

Published
2024
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159. Monitoring of Immune Memory by Phenotypical Lymphocyte Subsets Identikit: An Observational Study in a Blood Donors' Cohort.

Author

Di Domenico, Marina, Serretiello, Enrica, Smimmo, Annafrancesca, Vieira e Silva, Fábio França, Raimondi, Sonia Anna, Pascariello, Caterina, Marino, Maria Michela, Lo Muzio, Lorenzo, Caponio, Vito Carlo Alberto, Cantore, Stefania, and Ballini, Andrea

Subjects
ABO blood group system, LYMPHOCYTE subsets, B cells, BLOOD groups, IMMUNOLOGIC memory
Abstract

The cross-talk between the innate and adaptive immune response represents the first defense weapon against the threat of pathogens. Substantial evidence has shown a relationship between immune phenotype lymphocytes and COVID-19 disease severity and/or implication in susceptibility to SARS-CoV-2 infection. Recently, belonging to ABO blood groups has been investigated as a correlation factor to COVID-19 disease. This pilot study investigated lymphocyte typing in a cohort of blood donors to understand the underlying mechanism in SARS-CoV-2 infection linked to the blood group. The study cohort consisted of 20–64-year-old subjects, without comorbidities, from both sexes, who were COVID-19 vaccinated with previous or no infection history. Whole blood samples, collected at A.O.R.N. Sant'Anna and San Sebastiano Hospital (Campania Region), were processed by multiparametric cytofluorimetric assay, to characterize CD4+ helper and CD8+ cytotoxic T cell CD3+ subpopulations. The CD45RA, CCR7, CD27, CD28, CD57 and PD-1 markers were investigated to delineate the peripheral T-cell maturation stages. Differences were detected in ABO blood types in CD3+, CD4+ gated on CD3+, CD8+ and CD8+ gated on CD3+ percentage. These results contribute to identifying a memory cell "identikit" profile in COVID-19 disease, thus leading to a useful tool in precision medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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160. A Pilot Case Study on Innovative Behaviour: Lessons Learned and Directions for Future Work

Author

Monteiro, Cleviton, da Silva, Fabio Queda Bueno, and Capretz, Luiz Fernando

Subjects
Computer Science - Computers and Society
Abstract

Context: A case study is a powerful research strategy for investigating complex social-technical and managerial phenomena in real life settings. However, when the phenomenon has not been fully discovered or understood, pilot case studies are important to refine the research problem, the research variables, and the case study design before launching a full-scale investigation. The role of pilot case studies has not been fully addressed in empirical software engineering research literature. Objective: To explore the use of pilot case studies in the design of full-scale case studies, and to report the main lessons learned from an industrial pilot study. Method: We designed and conducted an exploratory case study to identify new relevant research variables that influence the innovative behaviour of software engineers in the industrial setting and to refine the full-scale case study design for the next phase of our research. Results: The use of a pilot case study identified several important research variables that were missing in the initial framework. The pilot study also supported a more sophisticated case study design, which was used to guide a full-scale study. Conclusions: When a research topic has not been fully discovered or understood, it is difficult to create a case study design that covers the relevant research variables and their potential relationships. Conducting a full-scale case study using an untested case design can lead to waste of resources and time if the design has to be reworked during the study. In these situations, the use of pilot case studies can significantly improve the case study design., Comment: 6 pages in 10th International Symposium on Empirical Software Engineering and Measurement (ESEM), Ciudad Real, Spain, September 2016

Published
2016
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161. The Innovative Behaviour of Software Engineers: Findings from a Pilot Case Study

Author

Monteiro, Cleviton, da Silva, Fabio Queda Bueno, and Capretz, Luiz Fernando

Subjects
Computer Science - Software Engineering
Abstract

Context: In the workplace, some individuals engage in the voluntary and intentional generation, promotion, and realization of new ideas for the benefit of individual performance, group effectiveness, or the organization. The literature classifies this phenomenon as innovative behaviour. Despite its importance to the development of innovation, innovative behaviour has not been fully investigated in software engineering. Objective: To understand the factors that support or inhibit innovative behaviour in software engineering practice. Method: We conducted a pilot case study in a Canadian software company using interviews and observations as data collection techniques. Using qualitative analysis, we identified relevant factors and relationships not addressed by studies from other areas. Results: Individual innovative behaviour is influenced by individual attitudes and also by situational factors such as relationships in the workplace, organizational characteristics, and project type. We built a model to express the interacting effects of these factors. Conclusions: Innovative behaviour is dependent on individual and contextual factors. Our results contribute to relevant impacts on research and practice, and to topics that deserve further study., Comment: 10 pages

Published
2016
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164. EFEITOS DA FISIOTERAPIA AQUÁTICA NO TRATAMENTO DA OSTEOARTRITE DE JOELHO: REVISÃO SISTEMÁTICA

Author

Silva, Fábio Henrique da, primary, Baptista, Amanda Baraúna, additional, Jesus, Girliane Santana de, additional, Tomaz, Bianca De Moraes, additional, Miguel, Luciana Pinheiro, additional, Albuquerque, Luelia Teles Jaques de, additional, Moura-Fernandes, Marcia Cristina, additional, Coelho-Oliveira, Ana Carolina, additional, Silva, Aline Reis, additional, Silva, Francisco José Salustiano da, additional, Bernardo-Filho, Mario, additional, and Sá-Caputo, Danúbia da Cunha de, additional

Published
2022
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176. PRIMEIROS SOCORROS: PRINCIPAIS EMERGÊNCIAS CARDIOVASCULARES

Author

Souza, Isabelle Arruda Cavalcante, primary, Mendonça, Thiago Dutra, additional, Mendes Filho, Antonio Camilo Correia, additional, Martins, Lucas Albuquerque de Sousa, additional, Silva, Fábio Augusto Oliveira do Carmo, additional, Takagi, Isadora Miyuki, additional, Granja Filho, Geraldo José Coelho, additional, Andrade, José Guilherme Sousa, additional, Rodrigues, Marina Vaz, additional, and Alonso, Isabela de Angelles Floro, additional

Published
2022
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178. A PERCEPÇÃO DOS ENFERMEIROS SOBRE A UTILIZAÇÃO DA BRINQUEDOTECA NO CUIDADO À CRIANÇA HOSPITALIZADA

Author

Soares, Brenda Nascimento Peruhype, primary, Cavalcante, Bianca Araújo, additional, Ferreira, Maria Tamires Alves, additional, Gonçalves Neta, Francisca das Chagas Cunha, additional, Chagas, Diego Cipriano, additional, Santos, Lidyane Rodrigues Oliveira, additional, Oliveira, Ana Lívia Castelo Branco De, additional, Vasconcelos, Sílvia Alcântara, additional, Ribeiro, Ana Flávia da Silva, additional, Silva, Francisca Fabiana Peres Aragão da, additional, Silva, Fábio Soares Lima, additional, and Pereira, Conceição de Maria Alves, additional

Published
2022
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179. UMA ABORDAGEM QUALI-QUANTITATIVA DO PERFIL DO DISCENTE-PESQUISADOR DE ESTUDANTES DA ÁREA DE SAÚDE

Author

Zanandréa, Leticia Colodetti, primary, Aguilar, Rafael Leite, additional, Silva, Fábio José Alencar da, additional, Aguilar, Daniel Leite, additional, Demoner, Giuliane Colnago, additional, Ballarini, Isabelle Kaptzky, additional, Moreira, Ana Clara Stanzani, additional, Sagrillo, Brenda Ribeiro, additional, Pimentel, João Victor Ferreira, additional, Lavagnoli, Leandra Zanotelli, additional, Barcellos, Yasmeen, additional, and Paulo, Marcela Souza Lima, additional

Published
2022
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180. APROVEITAMENTO, CARACTERÍSTICAS FITOQUÍMICAS E ATIVIDADES BIOLÓGICAS DA CASCA DO MARACUJÁ AMARELO (PASSIFLORA EDULIS F. FLAVICARPA DEGENER): UMA REVISÃO BIBLIOGRÁFICA

Author

Almeida, Samira Lopes de, primary, Pereira, Luís Filipe Sá, additional, Silva, Fábio Morais da, additional, Nogueira, Ana Flávia Alves, additional, Santos, José Cleilson de Paiva dos, additional, Silva, Cecília Maria Lima, additional, M`batna, Alberto João, additional, Fernandes, Mirian Raquel do Nascimento, additional, Celestino, Juliana Jales de Holanda, additional, and Amaral, Jeferson Falcão do, additional

Published
2022
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181. IMPACTOS DA COVID-19 EM GESTANTES CARDIOPATAS

Author

Eduarda Almeida de Souza, Cicera, primary, da Costa Araújo, Paulo, additional, Henrique Abreu Belota, Luiz, additional, de Melo Xavier, Ana Luisa, additional, Costa Silva, Karoline, additional, Pereira Ibiapina Coêlho, Luana, additional, José Antônio da Silva, Fábio, additional, de Oliveira Teixeira, Raquel, additional, de Melo Souza Martins, Alison, additional, Maêdya Fernandes Cruz, Francisca, additional, Luz Miranda, Kennyana, additional, Evelin Atanázio Barbosa, Iris, additional, Mistilides Gomes, Gabriela, additional, Santos Borges, Thiago, additional, and Baroni Araujo, Gustavo, additional

Published
2022
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183. PLANTAS MEDICINAIS E FITOTERAPIA: SAÚDE, SUSTENTABILIDADE E BIODIVERSIDADE

Author

Santos, José Cleilson de Paiva dos Santos, primary, Almeida, Samira Lopes de, additional, Nogueira, Ana Flávia Alves, additional, M`batna, Alberto João, additional, Fernandes, Mirian Raquel do Nascimento, additional, Silva, Cecília Maria Lima, additional, Felício, Janiel Ferreira, additional, Silva, Fábio Morais da, additional, Silva, Francisco Danilo Ferreira Costa da, additional, and Amaral, Jeferson Falcão do, additional

Published
2022
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185. TECNOLOGIA SOCIAL PARA CONVIVÊNCIA NO SEMIÁRIDO: O CASO DAS CISTERNAS DE PLACAS

Author

SILVA, FÁBIO DA, primary, TAHIM, ELDA FONTINELE, additional, LOBO, EZEQUIEL ALVES, additional, NODARI, CRISTINE HERMANN, additional, PEREIRA, TARCIARA MAGLEY DA FONSECA, additional, NASCIMENTO, ANDERSON LOPES, additional, COSTA, SILDÁCIO LIMA DA, additional, LIMA, FABIO PAIVA DE, additional, GOMES, SÉRGIO CASTRO, additional, and FRANCISCO, DAYSE EMANUELLE CAMPELO, additional

Published
2022
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186. ATUAÇÃO DO ENFERMEIRO NA PREVENÇÃO DE INFECÇÃO DO TRATO URINÁRIO EM PACIENTES DE UNIDADES DE TERAPIA INTENSIVA

Author

Ribeiro, Aclênia Maria Nascimento, primary, Moreiras, Felipe de Sousa, additional, Oliveira, Carolline Mendes Ribeiro de, additional, Sousa, Naiana Lustosa de Araújo, additional, Furtado, Érida Zoé Lustosa, additional, Nascimento, Illana Silva, additional, Campelo, Eduardo Melo, additional, Silva, Fábio Soares Lima, additional, Toussaint, Luciana Spindola Monteiro, additional, Oliveira, Águida da Silva Castelo Branco, additional, Santos, Ana Lina Gomes dos, additional, and Carneiro, Carla Lorena Morais de Sousa, additional

Published
2022
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187. POTENCIAL TERAPÊUTICO DO ALHO PARA O TRATAMENTO DA HIPERTENSÃO ARTERIAL: UMA REVISÃO DA LITERATURA

Author

Silva, Arlene Pinto de Miranda, primary, Venâncio, Francisco Baltazar, additional, Menezes, Welton Felipe Nogueira, additional, Makabi, Zola Paulina Pedro, additional, Felício, Janiel Ferreira, additional, Silva, Fábio Morais da, additional, Batista, José Márcio Machado, additional, Monte, Aline Santos, additional, Nepomuceno, Francisco Washington Araújo Barros, additional, and Amaral, Jeferson Falcão do, additional

Published
2022
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188. EFEITOS DA DEPRESSÃO PÓS-PARTO NA SAÚDE MATERNA

Author

Souza, Cicera Eduarda Almeida de, primary, Silva, Fábio José Antonio da, additional, Silva, Raylton Aparecido Nascimento, additional, Alves, Letícia Olyntho Barreto, additional, Silva, Izabelle Barreto, additional, Silva, Isadora Barreto, additional, Costa, Yasmim Xavier Arruda, additional, Abrão, Ruhena Kelber, additional, Araújo, Paulo da Costa, additional, and Lima, Thiago Oliveira Sabino de, additional

Published
2022
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191. PIPER METHYSTICUM (KAVA-KAVA) E O SISTEMA NERVOSO CENTRAL: REVISÃO BIBLIOGRÁFICA

Author

Silva, Fábio Morais da, primary, Venâncio, Francisco Baltazar, additional, Djú, Tomás Manuel, additional, Saraiva, Emmanoel Peixoto, additional, Medeiros, Cybelle Façanha Barreto, additional, Pereira, Rosiane Barros, additional, Marciel, Antônio Auberson Martins, additional, Bandeira, Nayara Cristina Rabelo, additional, Silva, Francisco Danilo Ferreira Costa da, additional, and Amaral, Jeferson Falcão do, additional

Published
2022
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198. Correlação entre alterações olfatórias e cognitivas observadas na Síndrome Pós-Covid-19: revisão integrativa

Author

Da Silva, Fábio Palma Albarado, primary, Koury, Gisele Vieira Hennemann, additional, Dezincourt, Alexandre Vasconcelos, additional, Fernandes, Giovana Gomes, additional, Da Silva, Rodrigo Lemos, additional, Do Amaral, Naiade de Oliveira, additional, Oliveira, Camila Araújo, additional, and Da Silva, Yasmim Corrêa, additional

Published
2024
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