151. Primary anaplastic pleomorphic xanthoastrocytoma with widespread neuroaxis dissemination at diagnosis––a pediatric case report and review of the literature
- Author
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Hidehisa Horiguchi, Toshiyuki Okazaki, Hiroyoshi Watanabe, Shinji Nagahiro, Teruyoshi Kageji, Takanori Hirose, Kazuhito Matsuzaki, and Toshihiro Ohnishi
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Vincristine ,Pathology ,Neurology ,medicine.medical_treatment ,Astrocytoma ,Diagnosis, Differential ,Lesion ,chemistry.chemical_compound ,medicine ,Humans ,Pleomorphic xanthoastrocytoma ,Chemotherapy ,Brain Neoplasms ,business.industry ,medicine.disease ,Spinal cord ,Magnetic Resonance Imaging ,Neoplasms, Complex and Mixed ,Carboplatin ,medicine.anatomical_structure ,Spinal Cord ,Oncology ,chemistry ,Child, Preschool ,Neurology (clinical) ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Anaplastic pleomorphic xanthoastrocytoma ,Head ,medicine.drug - Abstract
We report a 5 year-old boy with primary anaplastic pleomorphic xanthoastrocytoma (PXA) with whole neuroaxis dissemination at diagnosis who experienced the sudden onset of generalized convulsion. Head- and spinal magnetic resonance imaging (MRI) showed widespread gadolinium (Gd)-enhanced lesions extending to the bilateral frontal- and medial temporal lobes and the spinal cord. Subsequent MRI study demonstrated that the lesion size increased without any neurological deterioration. Under a histopathologic diagnosis of anaplastic PXA he underwent adjuvant chemotherapy consisting of 12 cycles of carboplatin and vincristine. The patient is alive without any neurological deficits; follow-up MRI showed that the lesions remained stable during 18 months of chemotherapy. We report a very rare pediatric case of primary anaplastic PXA with dissemination involving the entire neuroaxis at the time of diagnosis.
- Published
- 2009