Search

Your search keyword '"Shin, Hyoung Doo"' showing total 1,055 results
Start Over Author "Shin, Hyoung Doo"
1,055 results on '"Shin, Hyoung Doo"'

158. Association of Eotaxin gene family with asthma and serum total IgE

Author

Shin, Hyoung Doo, Kim, Lyoung Hyo, Park, Byung Lae, Jung, Ji Hyun, Kim, Jun Yeon, Chung, Il-Yup, Kim, Jung Sun, Lee, June Hyuk, Chung, Sun Hee, Kim, Yong Hoon, Park, Hae-Sim, Choi, Jeong Hee, Lee, Young Mok, Park, Sung Woo, Choi, Byoung Whui, Hong, Soo-Jong, and Park, Choon-Sik

Published
2003

163. Possible role of EMID2 on nasal polyps pathogenesis in Korean asthma patients

Author

Pasaje Charisse Flerida, Bae Joon Seol, Park Byung-Lae, Cheong Hyun Sub, Kim Jeong-Hyun, Jang An-Soo, Uh Soo-Taek, Park Choon-Sik, and Shin Hyoung Doo

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Since subepithelial fibrosis and protruded extracellular matrix are among the histological characteristics of polyps, the emilin/multimerin domain-containing protein 2 (EMID2) gene is speculated to be involved in the presence of nasal polyps in asthma and aspirin-hypersensitive patients. Methods To investigate the association between EMID2 and nasal polyposis, 49 single-nucleotide polymorphisms (SNPs) were genotyped in 467 asthmatics of Korean ancestry who were stratified further into 114 aspirin exacerbated respiratory disease (AERD) and 353 aspirin-tolerant asthma (ATA) subgroups. From pairwise comparison of the genotyped polymorphisms, 14 major haplotypes (frequency > 0.05) were inferred and selected for association analysis. Differences in the frequency distribution of EMID2 variations between polyp-positive cases and polyp-negative controls were determined using logistic analyses. Results Initially, 13 EMID2 variants were significantly associated with the presence of nasal polyps in the overall asthma group (P = 0.0008-0.05, OR = 0.54-1.32 using various modes of genetic inheritance). Although association signals from 12 variants disappeared after multiple testing corrections, the relationship between EMID2_BL1_ht2 and nasal polyposis remained significant via a codominant mechanism (Pcorr = 0.03). On the other hand, the nominal associations observed between the genetic variants tested for the presence of nasal polyps in AERD (P = 0.003-0.05, OR = 0.25-1.82) and ATA (P = 0.01-0.04, OR = 0.46-10.96) subgroups disappeared after multiple comparisons, suggesting lack of associations. Conclusions These preliminary findings suggest that EMID2_BL1_ht2 may be a susceptibility marker of inflammation of the nasal passages among Korean asthma patients.

Published
2012
Full Text
View/download PDF

166. Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of FSIP1: a Case-Case Study

Author

Choi Inseon S, Kim Mi-Kyeong, Uh Soo-Taek, Park Sung-Woo, Park Jong-Sook, Cheong Hyun Sub, Park Byung Lae, Pasaje Charisse, Lee Jin Sol, Bae Joon Seol, Park Tae Joon, Kim Jason, Kim Jeong Hyun, Cho Sang Heon, Choi Byoung Whui, Park Choon-Sik, and Shin Hyoung Doo

Subjects
Diseases of the respiratory system, RC705-779
Abstract

Abstract Background Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing. Aspirin is known to affect various parts inside human body, ranging from lung to spermatogenesis. FSIP1, also known as HDS10, is a recently discovered gene that encodes fibrous sheath interacting protein 1, and is regulated by amyloid beta precursor protein (APP). Recently, it has been reported that a peptide derived from APP is cleaved by α disintegrin and metalloproteinase 33 (ADAM33), which is an asthma susceptibility gene. It has also been known that the FSIP1 gene is expressed in airway epithelium. Objectives Aim of this study is to find out whether FSIP1 polymorphisms affect the onset of AIA in Korean population, since it is known that AIA is genetically affected by various genes. Methods We conducted association study between 66 single nucleotide polymorphisms (SNPs) of the FSIP1 gene and AIA in total of 592 Korean subjects including 163 AIA and 429 aspirin-tolerant asthma (ATA) patients. Associations between polymorphisms of FSIP1 and AIA were analyzed with sex, smoking status, atopy, and body mass index (BMI) as covariates. Results Initially, 18 SNPs and 4 haplotypes showed associations with AIA. However, after correcting the data for multiple testing, only one SNP showed an association with AIA (corrected P-value = 0.03, OR = 1.63, 95% CI = 1.23-2.16), showing increased susceptibility to AIA compared with that of ATA cases. Our findings suggest that FSIP1 gene might be a susceptibility gene for aspirin intolerance in asthmatics. Conclusion Although our findings did not suggest that SNPs of FSIP1 had an effect on the reversibility of lung function abnormalities in AIA patients, they did show significant evidence of association between the variants in FSIP1 and AIA occurrence among asthmatics in a Korean population.

Published
2010
Full Text
View/download PDF

175. Supplementary Figure 1. wGRS of Total cholesterol/HDL-c and Triglyceride/HDL-c ratios in Training and Test sets. from Prediction of cholesterol ratios within a Korean population

Author

Lee, Jin Sol, Cheong, Hyun Sub, and Shin, Hyoung Doo

Subjects
lipids (amino acids, peptides, and proteins)
Abstract

wGRS of Total cholesterol/HDL-c and Triglyceride/HDL-c ratios in Training and Test sets. Average wGRS was used for the graph. The standard deviation of wGRS in each quantile was used for error bars. Trend lines were shown as dotted lines with R2 and P-values.

Published
2017
Full Text
View/download PDF

176. Lack of Association between PRNP M129V Polymorphism and Multiple Sclerosis, Mild Cognitive Impairment, Alcoholism and Schizophrenia in a Korean Population

Author

Choi, Ihn-Geun, Woo, Sung-Il, Kim, Ho Jin, Kim, Dai-Jin, Park, Byung Lae, Cheong, Hyun Sub, Pasaje, Charisse Flerida A., Park, Tae Joon, Bae, Joon Seol, Chai, Young Gyu, and Shin, Hyoung Doo

Subjects
Male, lcsh:R5-920, Multiple Sclerosis, Polymorphism, Genetic, alcoholism, Genotype, Prions, animal diseases, Polymerase Chain Reaction, Prion Proteins, PRNP M129V, nervous system diseases, schizophrenia, mild cognitive impairment, Risk Factors, Case-Control Studies, mental disorders, Prion, Humans, Female, Genetic Predisposition to Disease, Other, Cognition Disorders, lcsh:Medicine (General), Aged
Abstract

The genetic variant at codon 129 (M129V) of the prion protein gene (PRNP) is considered to be a major genetic risk factor for prion diseases. In this study, we examined the possible genetic association of PRNP*129Val with multiple sclerosis (MS, n = 681), mild cognitive impairment (MCI, n = 801), alcoholism (n = 761) and schizophrenia (n = 715) in a Korean population, and compared the data with previous genetic association studies of the variant. The minor allele frequency of PRNP*129Val (MAF = 0.025) was significantly lower in Korean population (n = 2,479) compared to Caucasian populations (P < 0.0001), suggestive of a weak influence of the variant in the previous population. Statistical analysis revealed no significant association between PRNP*129Val and MS (P = 0.76), MCI (P = 0.46), alcoholism (P = 0.84) and schizophrenia (P = 0.69). These findings were discussed in the context of prior inconsistent reports on the role of PRNP*129Val polymorphism in several diseases. Results from this study may provide further evidence that PRNP M129V is not a genetic susceptibility factor for MS, MCI, alcoholism and schizophrenia in a Korean population.

Published
2010

179. Identification of additional EHMT2 variant associated with the risk of chronic hepatitis B by GWAS follow-up study

Author

Shin, Joong-Gon, primary, Cheong, Hyun Sub, additional, Kim, Jason Yongha, additional, Lee, Jeong-Hoon, additional, Yu, Su Jong, additional, Yoon, Jung-Hwan, additional, Cheong, Jae Youn, additional, Cho, Sung Won, additional, Park, Neung Hwa, additional, Namgoong, Suhg, additional, Kim, Lyoung Hyo, additional, Kim, Yoon Jun, additional, and Shin, Hyoung Doo, additional

Published
2017
Full Text
View/download PDF

182. X Chromosome-wide Association Study Identifies a Susceptibility Locus for Inflammatory Bowel Disease in Koreans

Author

Lee, Ho-Su, primary, Oh, Hyunjung, additional, Yang, Suk-Kyun, additional, Baek, Jiwon, additional, Jung, Seulgi, additional, Hong, Myunghee, additional, Kim, Kyung Mo, additional, Shin, Hyoung Doo, additional, Kim, Kyung-Jo, additional, Park, Sang Hyoung, additional, Ye, Byong Duk, additional, Han, Buhm, additional, and Song, Kyuyoung, additional

Published
2017
Full Text
View/download PDF

183. PRMT8 Controls the Pluripotency and Mesodermal Fate of Human Embryonic Stem Cells By Enhancing the PI3K/AKT/SOX2 Axis

Author

Jeong, Ho-Chang, primary, Park, Soon-Jung, additional, Choi, Jong-Jin, additional, Go, Young-Hyun, additional, Hong, Soon-Ki, additional, Kwon, Ok-Seon, additional, Shin, Joong-Gon, additional, Kim, Rae-Kwon, additional, Lee, Mi-Ok, additional, Lee, Su-Jae, additional, Shin, Hyoung Doo, additional, Moon, Sung-Hwan, additional, and Cha, Hyuk-Jin, additional

Published
2017
Full Text
View/download PDF

185. Genetic restriction of HIV-1 pathogenesis to AIDS by promoter alleles of IL10

Author

Shin, Hyoung Doo, Winkler, Cheryl, Stephens, J. Claiborne, Bream, Jay, Young, Howard, Goedert, James J., O'Brien, Thomas R., Vlahov, David, Buchbinder, Susan, Giorgi, Janis, Rinaldo, Charles, Donfield, Sharyne, Willoughby, Anne, O'Brien, Stephen J., and Smith, Michael W.

Subjects
HIV (Viruses) -- Genetic aspects, AIDS (Disease) -- Genetic aspects, Promoters (Genetics) -- Research, Cytokines -- Physiological aspects, Viruses -- Reproduction, Genetic polymorphisms -- Research, Genetic transcription -- Research, Science and technology
Abstract

IL10 is a powerful TH-2 cell cytokine produced by lymphoid cells that limits HIV-1 replication in vivo, ostensibly by inhibiting macrophage/monocyte and T-cell lymphocyte replication and secretion of inflammatory cytokines (IL1, TNF[Alpha], IL6, IL8, and IL12). A genetic epidemiological scan of patients enrolled in AIDS cohorts for candidate gene-linked short tandem repeat polymorphisms revealed significant genotype associations for HIV-1 infection and progression to AIDS with markers adjacent to and tracking (by linkage disequilibrium) common single nucleotide polymorphic variants in the IL10 promoter region. Individuals carrying the IL10-5'-592A (IL10-5'A) promoter allele possibly were at increased risk for HIV-1 infection, and once infected they progressed to AIDS more rapidly than homozygotes for the alternative IL10-5'-592 C/C (IL10-+/+) genotype, particularly in the later stages of HIV-1 infection. An estimated 25-30% of long-term nonprogressors (who avoid clinical AIDS for 10 or more years after HIV-1 infection) can be attributed to their IL10-+/+ promoter genotype. Alternative IL10 promoter alleles are functionally distinct in relative IL10 production, in retention of an avian erythroblastosis virus transcription factor recognition sequence and in binding to specific putative nuclear transcription factors, suggesting a potential mechanism whereby IL10-5'A down-regulation of inhibitory IL10 facilitates HIV-1 replication in vivo, accelerating the onset of AIDS.

Published
2000

188. Genetic variants of the gasdermin B gene associated with the development of aspirin-exacerbated respiratory diseases

Author

Kim, Lyoung Hyo, primary, Chang, HunSoo, additional, Namgoong, Suhg, additional, Kim, Ji On, additional, Cheong, Hyun Sub, additional, Lee, Seo-Gyeong, additional, Park, Jong Sook, additional, Baek, Ae Rin, additional, Koo, So-My, additional, Choi, Inseon S., additional, Kim, Mi-kyeong, additional, Park, Hea-Sim, additional, Park, Choon-Sik, additional, and Shin, Hyoung Doo, additional

Published
2017
Full Text
View/download PDF

189. RNA-Seq for Gene Expression Profiling of Human Necrotizing Enterocolitis: a Pilot Study

Author

Jung, Kyuwhan, primary, Koh, InSong, additional, Kim, Jeong-Hyun, additional, Cheong, Hyun Sub, additional, Park, Taejin, additional, Nam, So Hyun, additional, Jung, Soo-Min, additional, Sio, Cherry Ann, additional, Kim, Su Yeong, additional, Jung, Euiseok, additional, Lee, Byoungkook, additional, Kim, Hye-Rim, additional, Shin, Eun, additional, Jung, Sung-Eun, additional, Choi, Chang Won, additional, Kim, Beyong Il, additional, Jung, Eunyoung, additional, and Shin, Hyoung Doo, additional

Published
2017
Full Text
View/download PDF

193. Trans-ethnic meta-analysis of genome-wide association studies for Hirschsprung disease

Author

Tang, Clara Sze-man, primary, Gui, Hongsheng, additional, Kapoor, Ashish, additional, Kim, Jeong-Hyun, additional, Luzón-Toro, Berta, additional, Pelet, Anna, additional, Burzynski, Grzegorz, additional, Lantieri, Francesca, additional, So, Man-ting, additional, Berrios, Courtney, additional, Shin, Hyoung Doo, additional, Fernández, Raquel M., additional, Le, Thuy-Linh, additional, Verheij, Joke B.G.M., additional, Matera, Ivana, additional, Cherny, Stacey S., additional, Nandakumar, Priyanka, additional, Cheong, Hyun Sub, additional, Antiñolo, Guillermo, additional, Amiel, Jeanne, additional, Seo, Jeong-Meen, additional, Kim, Dae-Yeon, additional, Oh, Jung-Tak, additional, Lyonnet, Stanislas, additional, Borrego, Salud, additional, Ceccherini, Isabella, additional, Hofstra, Robert M.W., additional, Chakravarti, Aravinda, additional, Kim, Hyun-Young, additional, Sham, Pak Chung, additional, Tam, Paul K.H., additional, and Garcia-Barceló, Maria-Mercè, additional

Published
2016
Full Text
View/download PDF

194. Identification of novelOCT4genetic variant associated with the risk of chronic hepatitis B in a Korean population

Author

Shin, Joong-Gon, primary, Cheong, Hyun Sub, additional, Lee, Kwanghyun, additional, Ju, Bong-Gun, additional, Lee, Jeong-Hoon, additional, Yu, Su Jong, additional, Yoon, Jung-Hwan, additional, Cheong, Jae Youn, additional, Cho, Sung Won, additional, Park, Neung Hwa, additional, Namgoong, Suhg, additional, Kim, Lyoung Hyo, additional, Kim, Yoon Jun, additional, and Shin, Hyoung Doo, additional

Published
2016
Full Text
View/download PDF

196. Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans

Author

Ye, Byong Duk, primary, Choi, Hyunchul, additional, Hong, Myunghee, additional, Yun, Woo Jin, additional, Low, Hui-Qi, additional, Haritunians, Talin, additional, Kim, Kyung-Jo, additional, Park, Sang Hyoung, additional, Lee, Inchul, additional, Bang, So-Young, additional, Kim, Tae-Hwan, additional, Shin, Hyoung Doo, additional, Kang, Daehee, additional, Youn, Hee-Shang, additional, Li, Yi, additional, Liu, Jianjun, additional, McGovern, Dermot P. B., additional, Yang, Suk-Kyun, additional, and Song, Kyuyoung, additional

Published
2016
Full Text
View/download PDF

199. Genome‐wide association study with the risk of schizophrenia in a Korean population

Author

Kim, Lyoung Hyo, primary, Park, Byung Lae, additional, Cheong, Hyun Sub, additional, Namgoong, Suhg, additional, Kim, Ji On, additional, Kim, Jeong‐Hyun, additional, Shin, Joong‐Gon, additional, Park, Chul Soo, additional, Kim, Bong‐Jo, additional, Kim, Jae Won, additional, Choi, Ihn‐Geun, additional, Hwang, Jaeuk, additional, Shin, Hyoung Doo, additional, and Woo, Sung‐Il, additional

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results