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152. Role of Interleukin 16 in Multiple Myeloma

Author

Atanackovic, D., primary, Hildebrandt, Y., additional, Templin, J., additional, Cao, Y., additional, Keller, C., additional, Panse, J., additional, Meyer, S., additional, Reinhard, H., additional, Bartels, K., additional, Lajmi, N., additional, Sezer, O., additional, Zander, A. R., additional, Marx, A. H., additional, Uhlig, R., additional, Zustin, J., additional, Bokemeyer, C., additional, and Kroger, N., additional

Published
2012
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154. A phase lb study of oral panobinostat and IV bortezomib in relapsed or relapsed and refractory multiple myeloma.

Author

San-Miguel, J. F., primary, Richardson, P. G. G., additional, Sezer, O., additional, Guenther, A., additional, Siegel, D. S. D., additional, Blade, J., additional, LeBlanc, R., additional, Sutherland, H. J., additional, Mateos, M., additional, Gramatzki, M., additional, Hazell, K. M., additional, Bengoudifa, B., additional, Bourquelot, P. M., additional, and Anderson, K. C., additional

Published
2011
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156. Autorenverzeichnis

Author

Andresen, V., Angenendt, J., Anthoni, C., Appenrodt, B., Arbogast, M., Arco, G., Atta, J., Auer, M., Auernhammer, C., Autenrieth, I.B., Avenhaus, W., Bachem, R., Backmund, M., Bänsch, D., Ballauff, A., Baltzer, J., Barth, J., Batra, A., Bazarra-Castro, M.A., Beck, S., Becker, K., Becker, Karsten, Behr, J., Behrens, A., Belyaev, O., Bender-Götze, Ch., Bengel, J., Benz, M., Haunerschen, von, Berberich, J., Berger, M., Berner, R., Berr, F., S.C., Blank, N., Bleh, C., Blind, Eberhard, Blum, H.E., Bock, N., Bockhorn, M., Böhler, J., Böhm, M., Bokemeyer, D., Bönner, G., Bork, K., Born, G., Brandt, Thomas, Braun, J., Bruch, H.-P., Brümmendorf, T.H., Brüwer, M., Brunnberg, U., Buchfelder, M., Buchkremer, G., Büchler, M.W., Carl, H.-D., Castell, S., Daniels, C., Daum, S., Detter, C., Deuschl, G., Dieckmann, E., Diederich, S., Diehm, C., Diemer, T., Diener, H.C., Diepolder, H., Distler, J., Dörner, T., Prof. Dr., Domagk, D., Domschke, W., Dragu, A., Dralle, H., Dreyling, M., van, P., Dürk, T., Ebert, D., Ehlebracht-König, I., Elger, C.E., Ell, C., Ellinger, J., Emons, G., Engel, O., Enzensberger, W., Epple, H.-J., Erbel, R., Fassnacht, M., Feußner, Hubertus, Fichter, M., Fiegel, P., Filipas, D., Fisang, C., Fisch, M., Fischbach, W., Fischer, N., Fischer, M., Flamme, C.H., Fleckenstein, K., Floege, J., Fluhr, G., Fölsch, U.R., Forsting, M., Fottner, C., Frank, W., Frey, N., Freyberger, H., Friese, K., Frilling, A., habil, PD. Dr., Frommberger, U., Frühmorgen, P., Fuss, Johannes, Gätje, R., Galle, P.R., Geidel, S., Geiß, H.-Ch., Genth, Ekkehard, Gilsbach, J.M., Gingelmaier, A., Goebel, F.-D., Göhl, J., Gökbuget, N., Gold, R., Gonzalez-Carmona, M.A., Gossé, F., Grabitz, K., Greetfeld, M., Gries, F.A., Grosch-Wörner, I., Grüner, N., Grünke, M., Grüters-Kieslich, A., Gülberg, V., Haak, T., Häfner, R., Härter, M., Hagenacker, T., Hahn, S., Hahner, S., Haidl, G., Hammer, M., Hammersen, F., Handrick, W., Hanisch, F., Hansen, M.P., Hanke, Sara, Haschka, J., Hasslacher, C., Hauer, Th., Hauptmann, A., Heckmann, M., Heidbreder, E., Heim, U., Heindel, W., Heitmann, J., Hegenbart, U., Hermann, W., Herrmann, J.M., Herpertz-Dahlmann, B., Heßlinger, B., Heuß, D., Heußner, P., Hiller, E., Hirner, A., Hölscher, A.H., Hölzen, J., Hörl<ce:sup loc='post">†</ce:sup>, W.H., Hörle, S., Hof, H., Hofmann, W.-K., Hohenberger, W., Hohenfellner, U., Holler, E., Holtmann, G., Honegger, J., Hopf, H.C., Horch, R.E., Hornke, I., Hornung, T., Huber, R.M., Hueber, A., Hübner, J., Hummel, R., Irmscher, S., Janßen, O.E., Jelinek, T., Jendrissek, K.A., Jonas, S., Jost, E., Jung, H.H., Kahaly, G.J., Kalden, J.R., Kalff, J., Kapellen, T., Karaus, M., Kastrup, O., Katsoulis, S., Katus, H., Kaudel, C.P., Kaulitz, R., Keck, C., Keller, F., Kellnar, S., Kiehne, K., Kiess, W., Kindermann, M., Kirschbaum, A., Klein, M., Kleindienst, A., Kneitz, C., von Kodolitsch, Y., Köhler, D., Kessler, H.P., Köhler, G., Köhler, H., Köhler, L., Köhler, M., Köhnke, M., Königs, C., Köninger, J., Könsgen-Mustea, D., Köster, R., Kötter, I., Kohne, E., Kolb, H.-J., Koletzko, S., Kollmar, R., Konstantinidis, S., Koop, K., Kopp, H.G., Koschinsky, T., Kramer, H.J., Krauss, J., Kreis, M.E., Kremer, B., Kroemer, H.K., Kröner-Herwig, B., Kroll, P., Külz, A.K., Kuhl, H., Kuipers, J.G., Laaser, M., Lamla, U., Lammert, F., Langer, M., Laß, M., Laukötter, M., Layer, P., Leffler, M., Lehnert, H., Lehrke, M., Lembcke, B., Lerch, M.M., Liebe, S., Lieber, A., Limmroth, V., Lochs, H., Loddenkemper, R., Löhr, J.-M., Löscher, T., Loh, A., Lorenz, H.-M., Lorenz, J., Lügering, N., Luster, M., Lux, G., Luzar, O., Maercker, A., Magdorf, K., Mallmann, P., Marth, T., May, K., Mayerle, J., Meinertz, T., Melichar, V., Merle, U., Meyer, H.J., Meyer, Th., Meyer-Lehnert, H., Meyer-Marcotty, A., Michels, H., Möbius, C., Möddel, G., Möhler, M., Mönnikes, H., Mössner, J., Mohaupt, M.G., Müller, S.C., Müller, S.A., Müller-Lissner, S., Müller-Quernheim, J., Muntau, A., Musholt, T.J., Nacimiento, W., Nattermann, J., Nelles, G., Neubrand, M., Neuhäuser, C., Neuhaus, P., Neumann, P.-A., Neundörfer, B., Nicolai, T., Niebling, W.-B., Niehues, T., Nilius, G., Nolde, J., Noth, J., Olschewski, H., Ostermeyer, J., Ott, C., Pahernik, S., Palmes, D., Pankratius, U., Parhofer, K., Paschke, R., Passlick, B., Pech, O., Pelster, F.W., Petersen, E.E., Petri, E., Pfaffenbach, B., Pfeifer, M., Pfeiffer, T., Pfister, H.W., Diplom-Gesundheitswirt, Pickel, J., Pilatz, A., Pirlich, M., Polykandriotis, E., Pontz, B., Possinger, K., Pohl-Koppe, A., Pohle, T., Prange, H., Prasse, A., Pruß, A., Rädle, J., Raile, K., Randerath, W., Rascher, W., Rauch, B., Raue, F., Raziorruh, B., Rech, J., Regierer, A.C., Reichel, C., Reindl, C., Reinhardt, D., Reißfelder, C., Rendl, J., Reuss-Borst, M., Rieckmann, P., Riedner, C., Rietschel, E., Rijcken, E., Rister, M., Rödder, K., Rogenhofer, S., Roos, F.C., Roos, R., Rosskopf, D., Rudnik-Schöneborn, S., Rudofsky<ce:sup loc='post">†</ce:sup>, G., Ruhnke, M., Ruß, M., Rust, C.F., Saborowski, F., Sailer, M., Salakdeh, M. Sedigh, Samtleben, Walter, Sandmann, W., Sauerbruch, T., Schaal, K.P., Schackert, G., Schäfer-Graf, U., Schäfers, M., Schalhorn, A., Schepp, W., Schetelig, J., Schifferdecker, M., Schipper, J., Schießl, A., Schlegel, U., Schliep, S., Schmid, A., Schmid, P., Schmidt, F., Schmied, B., Schmiegel, W., Schneider, A., Schneider, T., Schneider-Gold, C., Schnürch, H.-G., Schölmerich, J., Schönermarck, U., Schönhofer, B., Schönland, S., Scholz, H., Schopohl, J., Schott, G., Schrader, J., Schraml, A., Schrezenmeier, H., Schuchert, A., Schüßler, G., Schulze-Koops, H., Schuppan, D., Schuster, V., Schwab, S., Schwandner, O., Schwarz, C.H.M., Schwarz, T.F., Schweppe, K.W., Secknus, R., Segerer, S.E., Senninger, N., Serve, H., Seybold, U., Sezer, O., Siegmund, B., Siegmund, W., Siemon, G., Simmen, B.R., Simonetti, G., Sommer, C., Spengler, U., Sprott, H., Stabenow-Lohbauer, U., Stahl, M., Stalla, G., Stallmach, A., Stammschulte, T., Stebler, R., Stein, R., Steven, D., Sticherling, M., Stöhr, M., Strauch, U., Strauss, A., Strauß, H.-G., Stremmel, C., Stremmel, W., Strupp, M., Stüber, E., Stürz, H., Sure, U., Swoboda, B., Taube, C., Thiel, K., Thomssen, C., Thurau, K., Thöne, J., Thüroff, J., Tomiak, C., Toyka, K.V., Tröger, H., Trüeb, R.M., Tryba, M., Uhl, W., Ullerich, H., Unger, L., Vallböhmer, D., van Calker, D., Vloet, T., Voderholzer, U., Völkl, Thomas M.K., Vogel, T., Vogt, P., Wagenlehner, F.E.M., Wagner, A., Wagner, U., Wahn, V., Wallesch, C.W., Watzka, F., Weber, K., Weber, L., Weber, M.M., Wehrmann, T., Weidner, W., Weinke, T., Weiß, M., Weis-Müller, B.T., Weller, Michael, Wenz, F., Werdan, K., Wettstein, M., Wick, M., Wiegratz, I., Willems, S., Wilke, H., Wintergerst, U., Wirth, M., Wolkersdörfer, G.W., Wüster, C., Zabel, F., Zeidler, H., Zeitz, M., Zerres, K., Ziemer, G., Zierz, S., Zimmermann, T., and Zwerina, J.

Published
2015
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160. Clinical and psychometric validation of the EORTC QLQ-CR29 questionnaire module to assess health-related quality of life in patients with colorectal cancer

Author

Whistance, R.N., primary, Conroy, T., additional, Chie, W., additional, Costantini, A., additional, Sezer, O., additional, Koller, M., additional, Johnson, C.D., additional, Pilkington, S.A., additional, Arraras, J., additional, Ben-Josef, E., additional, Pullyblank, A.M., additional, Fayers, P., additional, and Blazeby, J.M., additional

Published
2009
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164. B253 Serum DKK1 Levels in Multiple Myeloma

Author

Heider, U, primary, Kaiser, M, additional, Mieth, M, additional, Rademacher, J, additional, Lamottke, B, additional, Jakob, C, additional, Braendle, E, additional, Stover, D, additional, and Sezer, O, additional

Published
2009
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166. A337 Panobinostat and Bortezomib Phase I Trial in Multiple Myeloma

Author

Sezer, O, primary, Siegel, D, additional, San Miguel, J, additional, Mateos, MV, additional, Prosser, I, additional, Guenther, A, additional, Bladé, J, additional, Cavo, M, additional, Jalaluddin, M, additional, Hazell, K, additional, Bourquelot, PM, additional, and Anderson, KC, additional

Published
2009
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168. Hypoxie bei soliden Tumoren

Author

Beinert, T., primary, Mergenthaler, H.-G., additional, Sezer, O., additional, Löffel, J., additional, Binder, D., additional, Oehm, C., additional, Werner, T., additional, and Possinger, K., additional

Published
2008
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173. An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ-MY20) in assessing the quality of life of patients with multiple myeloma

Author

Cocks, K., primary, Cohen, D., additional, Wisløff, F., additional, Sezer, O., additional, Lee, S., additional, Hippe, E., additional, Gimsing, P., additional, Turesson, I., additional, Hajek, R., additional, Smith, A., additional, Graham, L., additional, Phillips, A., additional, Stead, M., additional, Velikova, G., additional, and Brown, J., additional

Published
2007
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177. Determinants of patient satisfaction in oncology settings from European and Asian countries: Preliminary results based on the EORTC IN-PATSAT32 questionnaire

Author

Brédart, A., primary, Coens, C., additional, Aaronson, N., additional, Chie, W.-C., additional, Efficace, F., additional, Conroy, T., additional, Blazeby, J.M., additional, Hammerlid, E., additional, Costantini, M., additional, Joly, F., additional, Schraub, S., additional, Sezer, O., additional, Arraras, J.I., additional, Rodary, C., additional, Costantini, A., additional, Mehlitz, M., additional, Razavi, D., additional, and Bottomley, A., additional

Published
2007
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180. An international prospective study of the EORTC cancer in-patient satisfaction with care measure (EORTC IN-PATSAT32)

Author

Brédart, A., primary, Bottomley, A., additional, Blazeby, J.M., additional, Conroy, T., additional, Coens, C., additional, D’Haese, S., additional, Chie, Wei-Chu, additional, Hammerlid, E., additional, Arraras, J.I., additional, Efficace, F., additional, Rodary, C., additional, Schraub, S., additional, Costantini, M., additional, Costantini, A., additional, Joly, F., additional, Sezer, O., additional, Razavi, D., additional, Mehlitz, M., additional, Bielska-Lasota, M., additional, and Aaronson, N.K., additional

Published
2005
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183. A Bioinspired in vitro Lung Model to Study Particokinetics of Nano-/Microparticles Under Cyclic Stretch and Air-Liquid Interface Conditions

Author

Ali Doryab, Mehmet Berat Taskin, Philipp Stahlhut, Andreas Schröppel, Sezer Orak, Carola Voss, Arti Ahluwalia, Markus Rehberg, Anne Hilgendorff, Tobias Stöger, Jürgen Groll, and Otmar Schmid

Subjects
lung cell model, cyclic stretch, ALI culture, bioinspired membrane, particle study, Biotechnology, TP248.13-248.65
Abstract

Evolution has endowed the lung with exceptional design providing a large surface area for gas exchange area (ca. 100 m2) in a relatively small tissue volume (ca. 6 L). This is possible due to a complex tissue architecture that has resulted in one of the most challenging organs to be recreated in the lab. The need for realistic and robust in vitro lung models becomes even more evident as causal therapies, especially for chronic respiratory diseases, are lacking. Here, we describe the Cyclic InVItroCell-stretch (CIVIC) “breathing” lung bioreactor for pulmonary epithelial cells at the air-liquid interface (ALI) experiencing cyclic stretch while monitoring stretch-related parameters (amplitude, frequency, and membrane elastic modulus) under real-time conditions. The previously described biomimetic copolymeric BETA membrane (5 μm thick, bioactive, porous, and elastic) was attempted to be improved for even more biomimetic permeability, elasticity (elastic modulus and stretchability), and bioactivity by changing its chemical composition. This biphasic membrane supports both the initial formation of a tight monolayer of pulmonary epithelial cells (A549 and 16HBE14o−) under submerged conditions and the subsequent cell-stretch experiments at the ALI without preconditioning of the membrane. The newly manufactured versions of the BETA membrane did not improve the characteristics of the previously determined optimum BETA membrane (9.35% PCL and 6.34% gelatin [w/v solvent]). Hence, the optimum BETA membrane was used to investigate quantitatively the role of physiologic cyclic mechanical stretch (10% linear stretch; 0.33 Hz: light exercise conditions) on size-dependent cellular uptake and transepithelial transport of nanoparticles (100 nm) and microparticles (1,000 nm) for alveolar epithelial cells (A549) under ALI conditions. Our results show that physiologic stretch enhances cellular uptake of 100 nm nanoparticles across the epithelial cell barrier, but the barrier becomes permeable for both nano- and micron-sized particles (100 and 1,000 nm). This suggests that currently used static in vitro assays may underestimate cellular uptake and transbarrier transport of nanoparticles in the lung.

Published
2021
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184. Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-STO 22, to assess quality of life in patients with gastric cancer

Author

Blazeby, J.M., primary, Conroy, T., additional, Bottomley, A., additional, Vickery, C., additional, Arraras, J., additional, Sezer, O., additional, Moore, J., additional, Koller, M., additional, Turhal, N.S., additional, Stuart, R., additional, van Cutsem, E., additional, D’haese, S., additional, and Coens, C., additional

Published
2004
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193. Therapie von Pilzinfektionen in der Hämatologie und Onkologie

Author

Böhme, A, primary, Ruhnke, M, additional, Karthaus, M, additional, Einsele, H, additional, Guth, S, additional, Heußel, G, additional, Heußel, C, additional, Junghanss, C, additional, Kern, W, additional, Kubin, T, additional, Sezer, O, additional, Silling, G, additional, Südhoff, T, additional, Szelényi, H, additional, and Ullmann, A, additional

Published
2001
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194. Mucormycoses

Author

Eucker, J., primary, Sezer, O., additional, Graf, Barbara, additional, and Possinger, K., additional

Published
2001
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