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669 results on '"Sellergren, Börje"'

155. Iniferter-mediated grafting of molecularly imprinted polymers on porous silica beads for the enantiomeric resolution of drugs.

Author

Gutiérrez‐Climente, Raquel, Gómez‐Caballero, Alberto, Halhalli, Mahadeo, Sellergren, Börje, Goicolea, M. Aránzazu, and Barrio, Ramón J.

Abstract

A surface-imprinted chiral stationary phase for the enantiomeric resolution of the antidepressant drug, citalopram, is presented in this work. N, N′-diethylaminodithiocarbamoylpropyl(trimethoxy)silane has been used as silane iniferter for the surface functionalization of the solid silica support. A molecularly imprinted polymer thin film, in the nm scale, was then grafted on the silanized silica using itaconic acid as the functional monomer and ethylene glycol dimethacrylate as the cross-linker in the presence of the template S-citalopram. The total monomer amount was calculated to obtain the desired thickness. Non-imprinted stationary phases were prepared similarly in the absence of S-citalopram. Characterization of the materials was carried out by scanning electron microscopy, thermogravimetric analysis, elemental analysis and Fourier transform infrared spectroscopy. Stationary phases have been applied to the chromatographic separation of the target. Conditions for best chromatographic resolution of the enantiomers were optimized, and it was found that a mobile phase consisting of a mixture of formate buffer (40 mM, pH 3) and acetonitrile (30:70 v/v) at 40 °C provided best results. Binding behaviour of the developed material was finally assessed by batch rebinding experiments. The obtained binding isotherm was fitted to different binding models being the Freundlich-Langmuir model, the one that best fitted the experimental data. The developed material has shown high selectivity for the target enantiomer, and the stationary phase could be undoubtedly exploited for chiral separation of the drug. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2016
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156. Molecularly imprinted polymers grafted to flow through poly(trimethylolpropane trimethacrylate) monoliths for capillary-based solid-phase extraction

Author

Courtois, Julien, Fischer, Gerd, Sellergren, Börje, Irgum, Knut, Courtois, Julien, Fischer, Gerd, Sellergren, Börje, and Irgum, Knut

Abstract

Monolithic previous termmolecularly imprinted polymersnext term (mMIPs) have been synthesized in a novel way using a trimethylolpropane trimethacrylate core material photo-polymerized in situ in a 100 μm I.D. UV-transparent capillary and further photo-previous termgraftednext term to create specific cavities in the previous termgraftednext term layer. This polymerization technique allows the imprints to be directly created on the surface of the material using a minimum amount of template. Three different anaesthetics of similar structures (bupivacaine, mepivacaine and S-ropivacaine) were used as model target molecules to synthesize sample enrichment media. Hence, various mMIPs have been prepared and evaluated on a micro-system against each analyte in order to test the retention properties and cross-selectivities of the materials. The retention factors were determined and compared with the non-previous termimprintednext term reference column (mNIP), yielding high imprinting factors together with good selectivity factors between the three analytes. A study with a pure enantiomeric target was carried out to assess the degree of stereo-specific imprinting for injection of racemic mixtures. Finally, one column was previous termimprintednext term with an equimolar mixture of all three anaesthetics to provide further comprehension of the retention mechanism and accredit the possibility of using the material as a sample enrichment entity. Scanning electron microscopy (SEM), nitrogen absorption/desorption (BET) and mercury intrusion porosimetry were used to characterize the monolith and the mMIPs properties. Nuclear magnetic resonance (NMR) has been used to assess the similarities between the mMIP and mNIP.

Published
2006
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167. In vitro assessment of engineered nanomaterials using a hepatocyte cell line: cytotoxicity, pro-inflammatory cytokines and functional markers

Author

Kermanizadeh, Ali, primary, Pojana, Giulio, additional, Gaiser, Birgit K, additional, Birkedal, Renie, additional, Bilanicˇová, Dagmar, additional, Wallin, Håkan, additional, Jensen, Keld Alstrup, additional, Sellergren, Börje, additional, Hutchison, Gary R, additional, Marcomini, Antonio, additional, and Stone, Vicki, additional

Published
2012
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180. A Phosphotyrosine‐Imprinted Polymer Receptor for the Recognition of Tyrosine Phosphorylated Peptides

Author

Emgenbroich, Marco, primary, Borrelli, Cristiana, additional, Shinde, Sudhirkumar, additional, Lazraq, Issam, additional, Vilela, Filipe, additional, Hall, Andrew J., additional, Oxelbark, Joakim, additional, De Lorenzi, Ersilia, additional, Courtois, Julien, additional, Simanova, Anna, additional, Verhage, Jeroen, additional, Irgum, Knut, additional, Karim, Kal, additional, and Sellergren, Börje, additional

Published
2008
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186. Molecularly Imprinted Polymers with Stimuli-Responsive Affinity: Progress and Perspectives.

Author

Wei Chen, Yue Ma, Jianmin Pan, Zihui Meng, Guoqing Pan, and Sellergren, Börje

Subjects
IMPRINTED polymers, BIOREMEDIATION, GREEN technology, BIOTECHNOLOGY, ERGONOMICS
Abstract

Intelligent stimuli-responsive molecularly imprinted polymers (SR-MIPs) have attracted considerable research interest in recent years due to the potential applications in drug delivery, biotechnology and separation sciences. This review comprehensively summarizes various SR-MIPs, including the design and applications of thermo-responsive MIPs, pH-responsive MIPs, photo-responsive MIPs, biomolecule-responsive MIPs and ion-responsive MIPs. Besides the development of current SR-MIPs, the advantages as well as the disadvantages of current SR-MIPs were also displayed from different angles, especially preparation methods and application fields. We believe this review will be helpful to guide the design, development and application of SR-MIPs. [ABSTRACT FROM AUTHOR]

Published
2015
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193. Analysis of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in Urine by Extraction on a Molecularly Imprinted Polymer Column and Liquid Chromatography/Atmospheric Pressure Ionization Tandem Mass Spectrometry

Author

Xia, Yang, primary, McGuffey, James E., additional, Bhattacharyya, Sumita, additional, Sellergren, Börje, additional, Yilmaz, Ecevit, additional, Wang, Lanqing, additional, and Bernert, John T., additional

Published
2005
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