Search

Your search keyword '"Seidman, Michael"' showing total 1,511 results
Start Over Author "Seidman, Michael"
1,511 results on '"Seidman, Michael"'

159. A novel link to base excision repair?

Author

Wilson, David M. and Seidman, Michael M.

Subjects
Proteins, Biological sciences, Chemistry
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.tibs.2010.01.003 Byline: David M. Wilson, Michael M. Seidman Abstract: DNA interstrand crosslinks (ICLs) can arise from reactions with endogenous chemicals, such as malondialdehyde - a lipid peroxidation product - or from exposure to various clinical anti-cancer drugs, most notably bifunctional alkylators and platinum compounds. Because they covalently link the two strands of DNA, ICLs completely block transcription and replication, and, as a result, are lethal to the cell. It is well established that proteins that function in nucleotide excision repair and homologous recombination are involved in ICL resolution. Recent work, coupled with a much earlier report, now suggest an emerging link between proteins of the base excision repair pathway and crosslink processing. Author Affiliation: Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, IRP, 251 Bayview Blvd, Suite #100, BRC, Baltimore, MD 21224, USA

Published
2010

161. Your Children Will Be Next: Bombing and Propaganda in the Spanish Civil War, 1936-1939

Author

Seidman, Michael

Subjects
Mentiras necesarias: La batalla por la opinion britanica durante la Guerra Civil (Nonfiction work) -- Book reviews, Your Children Will Be Next: Bombing and Propaganda in the Spanish Civil War, 1936-1939 (Nonfiction work) -- Book reviews, Books -- Book reviews, History, Regional focus/area studies
Published
2009

169. Tricuspid Valve-in-Valve and Bioprosthetic Surgical Tricuspid and Pulmonic Valve Degeneration

Author

Sellers, Stephanie L., primary, Hensey, Mark, additional, Cartlidge, Timothy R.G., additional, Turner, Christopher T., additional, Lau, Karen, additional, Lai, Althea, additional, Salcudean, Hannah, additional, Sathananthan, Janarthanan, additional, McManus, Bruce M., additional, Granville, David J., additional, Payne, Geoffrey W., additional, Pibarot, Philippe, additional, Webb, John G., additional, Newby, David E., additional, Blanke, Philipp, additional, Seidman, Michael A., additional, Dweck, Marc R., additional, and Leipsic, Jonathon A., additional

Published
2020
Full Text
View/download PDF

175. Minimum number of 2'-O-(2-aminoethyl) residues required for gene knockout activity by triple helix forming oligonucleotides

Author

Puri, Nitin, Majumdar, Alokes, Cuenoud, Bernard, Natt, Francois, Martin, Pierre, Boyd, Andre, Miller, Paul S., and Seidman, Michael M.

Subjects
DNA -- Analysis, Oligodeoxynucleotides -- Physiological aspects, Microbiological assay -- Methods, Enzyme kinetics -- Physiological aspects, Biological sciences, Chemistry
Abstract

A threshold level of the triple helix forming oligonucleotides (TFOs), consisting of three or four 2'-AE residues, are 10-fold more active than those with just 2 2'-AE residues in a hypoxanthine phosphoribosyltransferase (HPRT) activity monitored gene knockout assays. Further, the frequencies of HPRT activity with the active TFOs are 300-400 fold higher than the background activity.

Published
2002

180. FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links

Author

Awate, Sanket, primary, Sommers, Joshua A, additional, Datta, Arindam, additional, Nayak, Sumeet, additional, Bellani, Marina A, additional, Yang, Olivia, additional, Dunn, Christopher A, additional, Nicolae, Claudia M, additional, Moldovan, George-Lucian, additional, Seidman, Michael M, additional, Cantor, Sharon B, additional, and Brosh, Robert M, additional

Published
2020
Full Text
View/download PDF

188. Evaluation of an Explanted Tiara Transcatheter Mitral Valve

Author

Sellers, Stephanie L., primary, Lai, Althea, additional, Salcudean, Hannah, additional, Huang, Alex L., additional, Sathananthan, Gnalini, additional, Blanke, Philipp, additional, Webb, John G., additional, Cheung, Anson W., additional, Leipsic, Jonathon A., additional, and Seidman, Michael A., additional

Published
2020
Full Text
View/download PDF

191. Clinical Practice Guideline: Nosebleed (Epistaxis) Executive Summary

Author

Tunkel, David E., primary, Anne, Samantha, additional, Payne, Spencer C., additional, Ishman, Stacey L., additional, Rosenfeld, Richard M., additional, Abramson, Peter J., additional, Alikhaani, Jacqueline D., additional, Benoit, Margo McKenna, additional, Bercovitz, Rachel S., additional, Brown, Michael D., additional, Chernobilsky, Boris, additional, Feldstein, David A., additional, Hackell, Jesse M., additional, Holbrook, Eric H., additional, Holdsworth, Sarah M., additional, Lin, Kenneth W., additional, Lind, Meredith Merz, additional, Poetker, David M., additional, Riley, Charles A., additional, Schneider, John S., additional, Seidman, Michael D., additional, Vadlamudi, Venu, additional, Valdez, Tulio A., additional, Nnacheta, Lorraine C., additional, and Monjur, Taskin M., additional

Published
2020
Full Text
View/download PDF

194. Reviews of Books

Author

Clúa Serena, Josep Antoni, primary, Maura, Juan Francisco, additional, Beusterien, John, additional, Ruán, Felipe E., additional, Breden, Simon, additional, Fernández, Esther, additional, Harkema, Leslie J., additional, Longhurst, C. A., additional, Seidman, Michael, additional, Evans, Danny, additional, Grocott, Chris, additional, Laraway, David, additional, Fontes da Costa, Palmira, additional, Tavárez, David, additional, Cabrera, Eduardo, additional, Henighan, Stephen, additional, and Briggs, Ronald, additional

Published
2019
Full Text
View/download PDF

195. Triplex formation by oligonucleotides containing 5-(1-propynyl)-2'-deoxyuridine: decreased magnesium dependence and improved intracellular gene targeting

Author

Lacoste, Jerome, Lacroix, Laurent, Reddoch, James F., Mergny, Jean-Louis, Levy, Dan D., Seidman, Michael M., Matteucci, Mark D., and Glazer, Peter M.

Subjects
Pyrimidines -- Research, Nucleotides -- Research, DNA -- Research, Biological sciences, Chemistry
Abstract

A study was conducted to analyze the effects of substitution of T with 5-(1-propynyl)-2'-deoxyuridine on triplex formation under physiologic conditions by pyrimidine triplex-forming oligonucleotides. Third-strand binding to the target duplexes was determined using gel mobility shift assays under native or denaturing conditions. Cells were then harvested for vector DNA isolation using an altered alkaline lysis process.

Published
1999

197. Contralateral hearing loss after vestibular schwannoma excision: a rare complication of neurotologic surgery

Author

Deeb, Robert H., Rock, Jack R., and Seidman, Michael D.

Subjects
Excision (Surgery) -- Complications and side effects -- Case studies, Acoustic neuroma -- Care and treatment -- Prognosis -- Case studies, Hearing loss -- Risk factors -- Diagnosis -- Care and treatment -- Case studies, Health
Abstract

Abstract We report a rare case of contralateral hearing loss after vestibular schwannoma excision in a 48-year-old man who underwent surgery via a suboccipital approach for removal of a nearly [...]

Published
2015

198. A Basis for Standardizing Superior Semicircular Canal Dehiscence Management.

Author

Cozart, Ashley C., Kennedy III, John T., and Seidman, Michael D.

Subjects
EVALUATION of medical care, CONFIDENCE intervals, DEAFNESS, SUPERIOR semicircular canal dehiscence syndrome, MAGNETIC resonance imaging, QUESTIONNAIRES, DESCRIPTIVE statistics, PHYSICIANS, COMPUTED tomography, EMAIL, SYMPTOMS
Abstract

Objectives: (1) To determine how otologic/neurotologic surgeons counsel patients with superior semicircular canal dehiscence (SSCD). (2) To understand the plethora of presenting symptoms associated with SSCD and appropriate management. (3) To suggest appropriate management; oftentimes avoiding surgery. Methods: This was a survey study of both community and academic physicians. A 23-question survey was distributed to all members of the American Neurotological (ANS) and American Otologic Societies (AOS) via email in the Fall of 2018. A total of 54 responses were received from a possible pool of 279 for a response rate of 19.4%. Inferences were made about the population through sample proportions and confidence intervals. Results: All respondents use computed tomography (CT) in diagnosing SSCD and 11.1% use CT exclusively. Cervical vestibular evoked myogenic potential (VEMP; 77.8%) are used more often than ocular VEMPs (38.9%). Magnetic resonance imaging (7.4%) is used infrequently; 96.3% of surgeons surveyed have seen patients with SSCD on imaging that are asymptomatic. Following surgical treatment, respondents reported balance issues and mild-to-moderate high-frequency sensorineural hearing loss (88.4%); 32.6% reported that the majority (>50%) of their patients needed further intervention after surgery, typically aggressive vestibular rehabilitation. Conclusions: There is a discrepancy in the systematic approach to SSCD between both the surgeons and the published literature. Patients with SSCD on ultra-high-resolution CT may have myriad symptoms while others are asymptomatic, and surgery may lead to additional complications. We will present a methodical recommendation to assist in the management of patients with SSCD depending upon their symptoms. This may improve patient selection, counseling, and outcomes. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

199. Electrical Modulation of Tinnitus-Related Activity

Author

Zhang, Jinsheng, Guan, Zhenlong, Ramachandran, Virginia, Dunford, Jonathan, Hoa, Michael, Pace, Edward, Mao, Johnny, Seidman, Michael, Elisevich, Kost, Bowyer, Susan, and Jiang, Quan

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results