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151. Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

Author

Corbett, Kizzmekia S., primary, Gagne, Matthew, additional, Wagner, Danielle A., additional, Connell, Sarah O’, additional, Narpala, Sandeep R., additional, Flebbe, Dillon R., additional, Andrew, Shayne F., additional, Davis, Rachel L., additional, Flynn, Barbara, additional, Johnston, Timothy S., additional, Stringham, Christopher, additional, Lai, Lilin, additional, Valentin, Daniel, additional, Van Ry, Alex, additional, Flinchbaugh, Zackery, additional, Werner, Anne P., additional, Moliva, Juan I., additional, Sriparna, Manjari, additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Tucker, Courtney, additional, Choi, Angela, additional, Koch, Matthew, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Alvarado, Gabriela S., additional, Henry, Amy R., additional, Laboune, Farida, additional, Schramm, Chaim A., additional, Zhang, Yi, additional, Wang, Lingshu, additional, Choe, Misook, additional, Boyoglu-Barnum, Seyhan, additional, Shi, Wei, additional, Lamb, Evan, additional, Nurmukhambetova, Saule T., additional, Provost, Samantha J., additional, Donaldson, Mitzi M., additional, Marquez, Josue, additional, Todd, John-Paul M., additional, Cook, Anthony, additional, Dodson, Alan, additional, Pekosz, Andrew, additional, Boritz, Eli, additional, Ploquin, Aurélie, additional, Doria-Rose, Nicole, additional, Pessaint, Laurent, additional, Andersen, Hanne, additional, Foulds, Kathryn E., additional, Misasi, John, additional, Wu, Kai, additional, Carfi, Andrea, additional, Nason, Martha C., additional, Mascola, John, additional, Moore, Ian N., additional, Edwards, Darin K., additional, Lewis, Mark G., additional, Suthar, Mehul S., additional, Roederer, Mario, additional, McDermott, Adrian, additional, Douek, Daniel C., additional, Sullivan, Nancy J., additional, Graham, Barney S., additional, and Seder, Robert A., additional

Published
2021
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152. The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

Author

Wang, Lawrence T., primary, Hurlburt, Nicholas K., additional, Schön, Arne, additional, Flynn, Barbara J., additional, Pereira, Lais S., additional, Dillon, Marlon, additional, Flores-Garcia, Yevel, additional, Bonilla, Brian, additional, Zavala, Fidel, additional, Idris, Azza H., additional, Francica, Joseph R., additional, Pancera, Marie, additional, and Seder, Robert A., additional

Published
2021
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153. Functional human IgA targets a conserved site on malaria sporozoites

Author

Tan, Joshua, primary, Cho, Hyeseon, additional, Pholcharee, Tossapol, additional, Pereira, Lais S., additional, Doumbo, Safiatou, additional, Doumtabe, Didier, additional, Flynn, Barbara J., additional, Schön, Arne, additional, Kanatani, Sachie, additional, Aylor, Samantha O., additional, Oyen, David, additional, Vistein, Rachel, additional, Wang, Lawrence, additional, Dillon, Marlon, additional, Skinner, Jeff, additional, Peterson, Mary, additional, Li, Shanping, additional, Idris, Azza H., additional, Molina-Cruz, Alvaro, additional, Zhao, Ming, additional, Olano, Lisa Renee, additional, Lee, Patricia J., additional, Roth, Alison, additional, Sinnis, Photini, additional, Barillas-Mury, Carolina, additional, Kayentao, Kassoum, additional, Ongoiba, Aissata, additional, Francica, Joseph R., additional, Traore, Boubacar, additional, Wilson, Ian A., additional, Seder, Robert A., additional, and Crompton, Peter D., additional

Published
2021
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154. A SARS-CoV-2 spike ferritin nanoparticle vaccine protects against heterologous challenge with B.1.1.7 and B.1.351 virus variants in Syrian golden hamsters

Author

Wuertz, Kathryn McGuckin, primary, Barkei, Erica K., additional, Chen, Wei-Hung, additional, Martinez, Elizabeth J., additional, Lakhal-Naouar, Ines, additional, Jagodzinski, Linda L., additional, Paquin-Proulx, Dominic, additional, Gromowski, Gregory D., additional, Swafford, Isabella, additional, Ganesh, Akshaya, additional, Dong, Ming, additional, Zeng, Xiankun, additional, Thomas, Paul V., additional, Sankhala, Rajeshwer S., additional, Hajduczki, Agnes, additional, Peterson, Caroline E., additional, Kuklis, Caitlin, additional, Soman, Sandrine, additional, Wieczorek, Lindsay, additional, Zemil, Michelle, additional, Anderson, Alexander, additional, Darden, Janice, additional, Hernandez, Heather, additional, Grove, Hannah, additional, Dussupt, Vincent, additional, Hack, Holly, additional, de la Barrera, Rafael, additional, Zarling, Stasya, additional, Wood, James F., additional, Froude, Jeffrey W., additional, Gagne, Matthew, additional, Henry, Amy R., additional, Mokhtari, Elham Bayat, additional, Mudvari, Prakriti, additional, Krebs, Shelly J., additional, Pekosz, Andrew S., additional, Currier, Jeffrey R., additional, Kar, Swagata, additional, Porto, Maciel, additional, Winn, Adrienne, additional, Radzyminski, Kamil, additional, Lewis, Mark G., additional, Vasan, Sandhya, additional, Suthar, Mehul, additional, Polonis, Victoria R., additional, Matyas, Gary R., additional, Boritz, Eli A., additional, Douek, Daniel C., additional, Seder, Robert A., additional, Daye, Sharon P., additional, Rao, Mangala, additional, Peel, Sheila A., additional, Gordon Joyce, M., additional, Bolton, Diane L., additional, Michael, Nelson L., additional, and Modjarrad, Kayvon, additional

Published
2021
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157. Evaluation of mRNA-1273 against SARS-CoV-2 B.1.351 Infection in Nonhuman Primates

Author

Corbett, Kizzmekia S., primary, Werner, Anne P., additional, O’ Connell, Sarah, additional, Gagne, Matthew, additional, Lai, Lilin, additional, Moliva, Juan I., additional, Flynn, Barbara, additional, Choi, Angela, additional, Koch, Matthew, additional, Foulds, Kathryn E., additional, Andrew, Shayne F., additional, Flebbe, Dillon R., additional, Lamb, Evan, additional, Nurmukhambetova, Saule T., additional, Provost, Samantha J., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Van Ry, Alex, additional, Flinchbaugh, Zackery, additional, Johnston, Timothy S., additional, Mokhtari, Elham Bayat, additional, Mudvari, Prakriti, additional, Henry, Amy R., additional, Laboune, Farida, additional, Chang, Becky, additional, Porto, Maciel, additional, Wear, Jaclyn, additional, Alvarado, Gabriela S., additional, Boyoglu-Barnum, Seyhan, additional, Todd, John-Paul M., additional, Bart, Bridget, additional, Cook, Anthony, additional, Dodson, Alan, additional, Pessaint, Laurent, additional, Steingrebe, Katelyn, additional, Elbashir, Sayda, additional, Andersen, Hanne, additional, Wu, Kai, additional, Edwards, Darin K., additional, Kar, Swagata, additional, Lewis, Mark G., additional, Bortiz, Eli, additional, Moore, Ian N., additional, Carfi, Andrea, additional, Suthar, Mehul S., additional, McDermott, Adrian, additional, Roederer, Mario, additional, Nason, Martha C., additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, Graham, Barney S., additional, and Seder, Robert A., additional

Published
2021
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158. Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

Author

Alter, Galit, primary, Irvine, Edward, additional, O'Neil, Anthony, additional, Darrah, Patricia, additional, Shin, Sally, additional, Choudhary, Alok, additional, Li, Wenjun, additional, Honnen, William, additional, Mehra, Smriti, additional, Kaushal, Deepak, additional, Gideon, Hannah, additional, Flynn, JoAnne, additional, Roederer, Mario, additional, Seder, Robert, additional, Pinter, Abraham, additional, and Fortune, Sarah, additional

Published
2021
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159. Robust IgM responses following vaccination are associated with prevention of Mycobacterium tuberculosis infection in macaques

Author

Irvine, Edward B., primary, O’Neil, Anthony, additional, Darrah, Patricia A., additional, Shin, Sally, additional, Choudhary, Alok, additional, Li, Wenjun, additional, Honnen, William, additional, Mehra, Smriti, additional, Kaushal, Deepak, additional, Gideon, Hannah Priyadarshini, additional, Flynn, JoAnne L., additional, Roederer, Mario, additional, Seder, Robert A., additional, Pinter, Abraham, additional, Fortune, Sarah, additional, and Alter, Galit, additional

Published
2021
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160. Intravenous BCG protects SIV+ macaques from tuberculosis.

Author

Larson, Erica C, primary, Rodgers, Mark A, additional, Ellis, Amy L, additional, Ameel, Cassaundra L, additional, Gleim, Janelle L, additional, Gubernat, Abigail K, additional, Balgeman, Alexis, additional, Moriarty, Ryan V, additional, Darrah, Patricia A, additional, Maiello, Pauline, additional, Roederer, Mario, additional, Seder, Robert A, additional, O’Connor, Shelby L, additional, and Scanga, Charles A, additional

Published
2021
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161. Immune Correlates of Protection by mRNA-1273 Immunization against SARS-CoV-2 Infection in Nonhuman Primates

Author

Corbett, Kizzmekia S., primary, Nason, Martha C., additional, Flach, Britta, additional, Gagne, Matthew, additional, O’ Connell, Sarah, additional, Johnston, Timothy S., additional, Shah, Shruti N., additional, Edara, Venkata Viswanadh, additional, Floyd, Katharine, additional, Lai, Lilin, additional, McDanal, Charlene, additional, Francica, Joseph R., additional, Flynn, Barbara, additional, Wu, Kai, additional, Choi, Angela, additional, Koch, Matthew, additional, Abiona, Olubukola M., additional, Werner, Anne P., additional, Alvarado, Gabriela S., additional, Andrew, Shayne F., additional, Donaldson, Mitzi M., additional, Fintzi, Jonathan, additional, Flebbe, Dillon R., additional, Lamb, Evan, additional, Noe, Amy T., additional, Nurmukhambetova, Saule T., additional, Provost, Samantha J., additional, Cook, Anthony, additional, Dodson, Alan, additional, Faudree, Andrew, additional, Greenhouse, Jack, additional, Kar, Swagata, additional, Pessaint, Laurent, additional, Porto, Maciel, additional, Steingrebe, Katelyn, additional, Valentin, Daniel, additional, Zouantcha, Serge, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Moliva, Juan I., additional, van de Wetering, Renee, additional, Boyoglu-Barnum, Seyhan, additional, Leung, Kwanyee, additional, Shi, Wei, additional, Yang, Eun Sung, additional, Zhang, Yi, additional, Todd, John-Paul M., additional, Wang, Lingshu, additional, Andersen, Hanne, additional, Foulds, Kathryn E., additional, Edwards, Darin K., additional, Mascola, John R., additional, Moore, Ian N., additional, Lewis, Mark G., additional, Carfi, Andrea, additional, Montefiori, David, additional, Suthar, Mehul S., additional, McDermott, Adrian, additional, Sullivan, Nancy J., additional, Roederer, Mario, additional, Douek, Daniel C., additional, Graham, Barney S., additional, and Seder, Robert A., additional

Published
2021
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162. Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine

Author

Wu, Kai, primary, Werner, Anne P., additional, Koch, Matthew, additional, Choi, Angela, additional, Narayanan, Elisabeth, additional, Stewart-Jones, Guillaume B.E., additional, Colpitts, Tonya, additional, Bennett, Hamilton, additional, Boyoglu-Barnum, Seyhan, additional, Shi, Wei, additional, Moliva, Juan I., additional, Sullivan, Nancy J., additional, Graham, Barney S., additional, Carfi, Andrea, additional, Corbett, Kizzmekia S., additional, Seder, Robert A., additional, and Edwards, Darin K., additional

Published
2021
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163. Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria

Author

Francica, Joseph R., primary, Shi, Wei, additional, Chuang, Gwo-Yu, additional, Chen, Steven J., additional, Da Silva Pereira, Lais, additional, Farney, S. Katie, additional, Flynn, Barbara J., additional, Ou, Li, additional, Stephens, Tyler, additional, Tsybovsky, Yaroslav, additional, Wang, Lawrence T., additional, Anderson, Alexander, additional, Beck, Zoltan, additional, Dillon, Marlon, additional, Idris, Azza H., additional, Hurlburt, Nicholas, additional, Liu, Tracy, additional, Zhang, Baoshan, additional, Alving, Carl R., additional, Matyas, Gary R., additional, Pancera, Marie, additional, Mascola, John R., additional, Kwong, Peter D., additional, and Seder, Robert A., additional

Published
2021
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164. T Cells Specific for a Mycobacterial Glycolipid Expand after Intravenous Bacillus Calmette–Guérin Vaccination

Author

Layton, Erik D., primary, Barman, Soumik, additional, Wilburn, Damien B., additional, Yu, Krystle K. Q., additional, Smith, Malisa T., additional, Altman, John D., additional, Scriba, Thomas J., additional, Tahiri, Nabil, additional, Minnaard, Adriaan J., additional, Roederer, Mario, additional, Seder, Robert A., additional, Darrah, Patricia A., additional, and Seshadri, Chetan, additional

Published
2021
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165. Vaccination with SARS-CoV-2 Spike Protein and AS03 Adjuvant Induces Rapid Anamnestic Antibodies in the Lung and Protects Against Virus Challenge in Nonhuman Primates

Author

Francica, Joseph R., primary, Flynn, Barbara J., additional, Foulds, Kathryn E., additional, Noe, Amy T., additional, Werner, Anne P., additional, Moore, Ian N., additional, Gagne, Matthew, additional, Johnston, Timothy S., additional, Tucker, Courtney, additional, Davis, Rachel L., additional, Flach, Britta, additional, O’Connell, Sarah, additional, Andrew, Shayne F., additional, Lamb, Evan, additional, Flebbe, Dillon R., additional, Nurmukhambetova, Saule T., additional, Donaldson, Mitzi M., additional, Todd, John-Paul M., additional, Zhu, Alex Lee, additional, Atyeo, Caroline, additional, Fischinger, Stephanie, additional, Gorman, Matthew J, additional, Shin, Sally, additional, Edara, Venkata Viswanadh, additional, Floyd, Katharine, additional, Lai, Lilin, additional, Tylor, Alida, additional, McCarthy, Elizabeth, additional, Lecouturier, Valerie, additional, Ruiz, Sophie, additional, Berry, Catherine, additional, Tibbitts, Timothy, additional, Andersen, Hanne, additional, Cook, Anthony, additional, Dodson, Alan, additional, Pessaint, Laurent, additional, Ry, Alex Van, additional, Koutsoukos, Marguerite, additional, Gutzeit, Cindy, additional, Teng, I-Ting, additional, Zhou, Tongqing, additional, Li, Dapeng, additional, Haynes, Barton F., additional, Kwong, Peter D., additional, McDermott, Adrian, additional, Lewis, Mark G., additional, Fu, Tong Ming, additional, Chicz, Roman, additional, van der Most, Robbert, additional, Corbett, Kizzmekia S., additional, Suthar, Mehul S., additional, Alter, Galit, additional, Roederer, Mario, additional, Sullivan, Nancy J., additional, Douek, Daniel C., additional, Graham, Barney S., additional, Casimiro, Danilo, additional, and Seder, Robert A., additional

Published
2021
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166. HIV Gag protein conjugated to a Toll-like receptor 7/8 agonist improves the magnitude and quality of Th1 and CD8+ T cell responses in nonhuman primates

Author

Wille-Reece, Ulrike, Flynn, Barbara J., Lore, Karin, Koup, Richard A., Kedl, Ross M., Mattapallil, Joseph J., Weiss, Walter R., Roederer, Mario, and Seder, Robert A.

Subjects
Immunology -- Research, AIDS vaccines -- Research, HIV (Viruses) -- Research, Science and technology
Abstract

Induction and maintenance of antibody and T cell responses will be critical for developing a successful vaccine against HIV. A rational approach for generating such responses is to design vaccines or adjuvants that have the capacity to activate specific antigen-presenting cells. In this regard, dendritic cells (DCs) are the most potent antigen-presenting cells for generating primary T cell responses. Here, we report that Toll-like receptor (TLR) agonists and ligands that activate DCs in vitro influence the magnitude and quality of the cellular immune response in nonhuman primates (NHPs) when administered with HIV Gag protein. NHPs immunized with HIV Gag protein and a TLR7/8 agonist or a TLR9 ligand [CpG oligodeoxynucleotides (CpG ODN)] had significantly increased Gag-specific T helper 1 and antibody responses, compared with animals immunized with HIV Gag protein alone. Importantly, conjugating the HIV Gag protein to the TLR7/8 agonist (GagTLR7/8 conjugate) dramatically enhanced the magnitude and altered the quality of the T helper I response, compared with animals immunized with HIV Gag protein and the TLR7/8 agonist or CpG ODN. Furthermore, immunization with the Gag-TLR7/8 conjugate vaccine elicited Gag-specific CD[8.sup.+] T responses. Collectively, our results show that conjugating HIV Gag protein to a TLR7/8 agonist is an effective way to elicit broad-based adaptive immunity in NHPs. This type of vaccine formulation should have utility in preventive or therapeutic vaccines in which humoral and cellular immunity is required. vaccine | dendritic cell | cross-presentation | cellular immunity

Published
2005

169. SARS-CoV-2 vaccination induces neutralizing antibodies against pandemic and pre-emergent SARS-related coronaviruses in monkeys

Author

Saunders, Kevin O., primary, Lee, Esther, additional, Parks, Robert, additional, Martinez, David R., additional, Li, Dapeng, additional, Chen, Haiyan, additional, Edwards, Robert J., additional, Gobeil, Sophie, additional, Barr, Maggie, additional, Mansouri, Katayoun, additional, Alam, S. Munir, additional, Sutherland, Laura L., additional, Cai, Fangping, additional, Sanzone, Aja M., additional, Berry, Madison, additional, Manne, Kartik, additional, Kapingidza, Anyway B., additional, Azoitei, Mihai, additional, Tse, Longping V., additional, Scobey, Trevor D., additional, Spreng, Rachel L., additional, Rountree, R. Wes, additional, DeMarco, C. Todd, additional, Denny, Thomas N., additional, Woods, Christopher W., additional, Petzold, Elizabeth W., additional, Oguin, Thomas H., additional, Sempowski, Gregory D., additional, Gagne, Matthew, additional, Douek, Daniel C., additional, Tomai, Mark A., additional, Fox, Christopher B., additional, Seder, Robert, additional, Wiehe, Kevin, additional, Weissman, Drew, additional, Pardi, Norbert, additional, Acharya, Priyamvada, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Moore, Ian N., additional, Montefiori, David C., additional, Baric, Ralph S., additional, and Haynes, Barton F., additional

Published
2021
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170. Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

Author

Kisalu, Neville K., primary, Pereira, Lais D., additional, Ernste, Keenan, additional, Flores-Garcia, Yevel, additional, Idris, Azza H., additional, Asokan, Mangaiarkarasi, additional, Dillon, Marlon, additional, MacDonald, Scott, additional, Shi, Wei, additional, Chen, Xuejun, additional, Pegu, Amarendra, additional, Schön, Arne, additional, Zavala, Fidel, additional, Balazs, Alejandro B., additional, Francica, Joseph R., additional, and Seder, Robert A., additional

Published
2021
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171. mRNA-1273 vaccine induces neutralizing antibodies against spike mutants from global SARS-CoV-2 variants

Author

Wu, Kai, primary, Werner, Anne P., additional, Moliva, Juan I., additional, Koch, Matthew, additional, Choi, Angela, additional, Stewart-Jones, Guillaume B. E., additional, Bennett, Hamilton, additional, Boyoglu-Barnum, Seyhan, additional, Shi, Wei, additional, Graham, Barney S., additional, Carfi, Andrea, additional, Corbett, Kizzmekia S., additional, Seder, Robert A., additional, and Edwards, Darin K., additional

Published
2021
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172. The functions of SARS-CoV-2 neutralizing and infection-enhancing antibodies in vitro and in mice and nonhuman primates

Author

Li, Dapeng, primary, Edwards, Robert J, additional, Manne, Kartik, additional, Martinez, David R., additional, Schäfer, Alexandra, additional, Alam, S. Munir, additional, Wiehe, Kevin, additional, Lu, Xiaozhi, additional, Parks, Robert, additional, Sutherland, Laura L., additional, Oguin, Thomas H., additional, McDanal, Charlene, additional, Perez, Lautaro G., additional, Mansouri, Katayoun, additional, Gobeil, Sophie M. C., additional, Janowska, Katarzyna, additional, Stalls, Victoria, additional, Kopp, Megan, additional, Cai, Fangping, additional, Lee, Esther, additional, Foulger, Andrew, additional, Hernandez, Giovanna E., additional, Sanzone, Aja, additional, Tilahun, Kedamawit, additional, Jiang, Chuancang, additional, Tse, Longping V., additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Cronin, Kenneth, additional, Gee-Lai, Victoria, additional, Deyton, Margaret, additional, Barr, Maggie, additional, Holle, Tarra Von, additional, Macintyre, Andrew N., additional, Stover, Erica, additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Scobey, Trevor D., additional, Rountree, Wes, additional, Wang, Yunfei, additional, Moody, M. Anthony, additional, Cain, Derek W., additional, DeMarco, C. Todd, additional, Denny, ThomasN., additional, Woods, Christopher W., additional, Petzold, Elizabeth W., additional, Schmidt, Aaron G., additional, Teng, I-Ting, additional, Zhou, Tongqing, additional, Kwong, Peter D., additional, Mascola, John R., additional, Graham, Barney S., additional, Moore, Ian N., additional, Seder, Robert, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Montefiori, David C., additional, Sempowski, Gregory D., additional, Baric, Ralph S., additional, Acharya, Priyamvada, additional, Haynes, Barton F., additional, and Saunders, Kevin O., additional

Published
2021
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176. Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells

Author

Baharom, Faezzah, primary, Ramirez-Valdez, Ramiro A., additional, Tobin, Kennedy K. S., additional, Yamane, Hidehiro, additional, Dutertre, Charles-Antoine, additional, Khalilnezhad, Ahad, additional, Reynoso, Glennys V., additional, Coble, Vincent L., additional, Lynn, Geoffrey M., additional, Mulè, Matthew P., additional, Martins, Andrew J., additional, Finnigan, John P., additional, Zhang, Xiao Meng, additional, Hamerman, Jessica A., additional, Bhardwaj, Nina, additional, Tsang, John S., additional, Hickman, Heather D., additional, Ginhoux, Florent, additional, Ishizuka, Andrew S., additional, and Seder, Robert A., additional

Published
2020
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178. Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

Author

Corbett, Kizzmekia S., primary, Flynn, Barbara, additional, Foulds, Kathryn E., additional, Francica, Joseph R., additional, Boyoglu-Barnum, Seyhan, additional, Werner, Anne P., additional, Flach, Britta, additional, O’Connell, Sarah, additional, Bock, Kevin W., additional, Minai, Mahnaz, additional, Nagata, Bianca M., additional, Andersen, Hanne, additional, Martinez, David R., additional, Noe, Amy T., additional, Douek, Naomi, additional, Donaldson, Mitzi M., additional, Nji, Nadesh N., additional, Alvarado, Gabriela S., additional, Edwards, Darin K., additional, Flebbe, Dillon R., additional, Lamb, Evan, additional, Doria-Rose, Nicole A., additional, Lin, Bob C., additional, Louder, Mark K., additional, O’Dell, Sijy, additional, Schmidt, Stephen D., additional, Phung, Emily, additional, Chang, Lauren A., additional, Yap, Christina, additional, Todd, John-Paul M., additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Browne, Shanai, additional, Greenhouse, Jack, additional, Putman-Taylor, Tammy, additional, Strasbaugh, Amanda, additional, Campbell, Tracey-Ann, additional, Cook, Anthony, additional, Dodson, Alan, additional, Steingrebe, Katelyn, additional, Shi, Wei, additional, Zhang, Yi, additional, Abiona, Olubukola M., additional, Wang, Lingshu, additional, Pegu, Amarendra, additional, Yang, Eun Sung, additional, Leung, Kwanyee, additional, Zhou, Tongqing, additional, Teng, I-Ting, additional, Widge, Alicia, additional, Gordon, Ingelise, additional, Novik, Laura, additional, Gillespie, Rebecca A., additional, Loomis, Rebecca J., additional, Moliva, Juan I., additional, Stewart-Jones, Guillaume, additional, Himansu, Sunny, additional, Kong, Wing-Pui, additional, Nason, Martha C., additional, Morabito, Kaitlyn M., additional, Ruckwardt, Tracy J., additional, Ledgerwood, Julie E., additional, Gaudinski, Martin R., additional, Kwong, Peter D., additional, Mascola, John R., additional, Carfi, Andrea, additional, Lewis, Mark G., additional, Baric, Ralph S., additional, McDermott, Adrian, additional, Moore, Ian N., additional, Sullivan, Nancy J., additional, Roederer, Mario, additional, Seder, Robert A., additional, and Graham, Barney S., additional

Published
2020
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180. Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

Author

Williams, Wilton B., primary, Meyerhoff, R. Ryan, additional, Edwards, RJ, additional, Li, Hui, additional, Nicely, Nathan I., additional, Henderson, Rory, additional, Zhou, Ye, additional, Janowska, Katarzyna, additional, Mansouri, Katayoun, additional, Manne, Kartik, additional, Stalls, Victoria, additional, Hsu, Allen L., additional, Borgnia, Mario J., additional, Stewart-Jones, Guillaume, additional, Lee, Matthew S., additional, Bronkema, Naomi, additional, Perfect, John, additional, Moody, M. Anthony, additional, Wiehe, Kevin, additional, Bradley, Todd, additional, Kepler, Thomas B., additional, Alam, S. Munir, additional, Parks, Robert J., additional, Foulger, Andrew, additional, Bonsignori, Mattia, additional, LaBranche, Celia C., additional, Montefiori, David C., additional, Seaman, Michael, additional, Santra, Sampa, additional, Francica, Joseph R., additional, Lynn, Geoffrey M., additional, Aussedat, Baptiste, additional, Walkowicz, William E., additional, Laga, Richard, additional, Kelsoe, Garnett, additional, Saunders, Kevin O., additional, Fera, Daniela, additional, Kwong, Peter D., additional, Seder, Robert A., additional, Bartesaghi, Alberto, additional, Shaw, George M., additional, Acharya, Priyamvada, additional, and Haynes, Barton F., additional

Published
2020
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181. Atypical B cells are a normal component of immune responses to vaccination and infection in humans

Author

Sutton, Henry J., primary, Aye, Racheal, additional, Idris, Azza H., additional, Vistein, Rachel, additional, Nduati, Eunice, additional, Kai, Oscar, additional, Mwacharo, Jedida, additional, Li, Xi, additional, Gao, Xin, additional, Andrews, T. Daniel, additional, Koutsakos, Marios, additional, Nguyen, Thi H. O., additional, Nekrasov, Maxim, additional, Milburn, Peter, additional, Ethala, Auda, additional, Berry, Andrea A., additional, Natasha, KC, additional, Chakravarty, Sumana, additional, Sim, B. Kim Lee, additional, Wheatley, Adam K., additional, Kent, Stephen J., additional, Hoffman, Stephen L., additional, Lyke, Kirsten E., additional, Bejon, Philip, additional, Luciani, Fabio, additional, Kedzierska, Katherine, additional, Seder, Robert A., additional, Ndungu, Francis M., additional, and Cockburn, Ian A., additional

Published
2020
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183. Sterile protection against human malaria by chemoattenuated PfSPZ vaccine

Author

Mordmller, Benjamin, Surat, Gzin, Lagler, Heimo, Chakravarty, Sumana, Ishizuka, Andrew S., Lalremruata, Albert, Gmeiner, Markus, Campo, Joseph J., Esen, Meral, Ruben, Adam J., Held, Jana, Calle, Carlos Lamsfus, Mengue, Juliana B., Gebru, Tamirat, Ibez, Javier, Sulyok, Mihly, James, Eric R., Billingsley, Peter F., Natasha, KC, Manoj, Anita, Murshedkar, Tooba, Gunasekera, Anusha, Eappen, Abraham G., Li, Tao, Stafford, Richard E., Li, Minglin, Felgner, Phil L., Seder, Robert A., Richie, Thomas L., Sim, B. Kim Lee, Hoffman, Stephen L., and Kremsner, Peter G.

Subjects
Prevention, Dosage and administration, Malaria vaccines -- Dosage and administration, Malaria -- Prevention
Abstract

Author(s): Benjamin Mordmller [1]; Gzin Surat [1]; Heimo Lagler [1, 2]; Sumana Chakravarty [3]; Andrew S. Ishizuka [4]; Albert Lalremruata [1]; Markus Gmeiner [1]; Joseph J. Campo [5]; Meral Esen [...]

Published
2017
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184. Plants as a Production and Delivery Vehicle for Orally Delivered Subunit Vaccines

Author

Kenney, Richard, primary, Edelman, Robert, additional, Podda, Audino, additional, Del Giudice, Giuseppe, additional, Gurunathan, Sanjay, additional, Klinman, Dennis, additional, Seder, Robert, additional, Dougan, Gordon, additional, Douce, Gill, additional, O’Hagan, Derek, additional, Lowell, George, additional, Burt, David, additional, White, Greg, additional, Fries, Louis, additional, Conner, Margaret, additional, Estes, Mary, additional, Glueck, Reinhard, additional, Mor, Tsafrir, additional, Mason, Hugh, additional, Arntzen, Charles, additional, Cardineau, Guy, additional, and Kirk, Dwayne, additional

Published
2004
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185. CONTRIBUTORS

Author

Aseffa, Abraham, primary, Ballou, W. Ripley, additional, Batson, Amie, additional, Best, Jennifer M., additional, Birmingham, Maureen, additional, Bjorvatn, Bjarne, additional, Bloom, Barry R., additional, Bresee, Joseph S., additional, Choi, Elisa I., additional, Clemens, John D., additional, Del Giudice, Giuseppe, additional, de Quadros, Ciro A., additional, Finlay, B. Brett, additional, Gentsch, Jon, additional, Gissmann, Lutz, additional, Glass, Roger I., additional, Glass, Sarah, additional, Greenwood, Brian, additional, Gumy, Alain, additional, Hackell, Jill G., additional, Halsey, Neal A., additional, Hoffman, Stephen L., additional, Koo, Hye-Won, additional, Lambert, Paul-Henri, additional, Launois, Pascal, additional, Letvin, Norman L., additional, Levine, Ruth E., additional, Louis, Jacques A., additional, Macklin, Ruth, additional, Mascola, John R., additional, Masignani, Vega, additional, Miller, Elizabeth, additional, Mulholland, Edward Kim, additional, O'shea, Siobhan, additional, Parashar, Umesh, additional, Pizza, Mariagrazia, additional, Plotkin, Stanley A., additional, Rappuoli, Rino, additional, Richie, Thomas L., additional, Röcken, Martin, additional, Salmaso, Stefania, additional, Seder, Robert A., additional, Seiguer, Erica, additional, Siegrist, Claire-Anne, additional, Stein, Claudia, additional, Tacchini-Cottier, Fabienne, additional, Tuomanen, Elaine I., additional, Voigt, Heike, additional, Weiser, Jeffrey N., additional, Young, Douglas B., additional, and Zinkernagel, Rolf M., additional

Published
2003
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189. A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Author

Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Kisalu, Neville K, Idris, Azza H, Weidle, Connor, Flores-Garcia, Yevel, Flynn, Barbara J, Sack, Brandon K, Murphy, Sean, Schön, Arne, Freire, Ernesto, Francica, Joseph R, Miller, Alex B, Gregory, Jason, March-Riera, Sandra, Liao, Hua-Xin, Haynes, Barton F, Wiehe, Kevin, Trama, Ashley M, Saunders, Kevin O, Gladden, Morgan A, Monroe, Anthony, Bonsignori, Mattia, Kanekiyo, Masaru, Wheatley, Adam K, McDermott, Adrian B, Farney, S Katie, Chuang, Gwo-Yu, Zhang, Baoshan, Kc, Natasha, Chakravarty, Sumana, Kwong, Peter D, Sinnis, Photini, Bhatia, Sangeeta N, Kappe, Stefan H I, Sim, B Kim Lee, Hoffman, Stephen L, Zavala, Fidel, Pancera, Marie, Seder, Robert A, Harvard University--MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Kisalu, Neville K, Idris, Azza H, Weidle, Connor, Flores-Garcia, Yevel, Flynn, Barbara J, Sack, Brandon K, Murphy, Sean, Schön, Arne, Freire, Ernesto, Francica, Joseph R, Miller, Alex B, Gregory, Jason, March-Riera, Sandra, Liao, Hua-Xin, Haynes, Barton F, Wiehe, Kevin, Trama, Ashley M, Saunders, Kevin O, Gladden, Morgan A, Monroe, Anthony, Bonsignori, Mattia, Kanekiyo, Masaru, Wheatley, Adam K, McDermott, Adrian B, Farney, S Katie, Chuang, Gwo-Yu, Zhang, Baoshan, Kc, Natasha, Chakravarty, Sumana, Kwong, Peter D, Sinnis, Photini, Bhatia, Sangeeta N, Kappe, Stefan H I, Sim, B Kim Lee, Hoffman, Stephen L, Zavala, Fidel, Pancera, Marie, and Seder, Robert A

Abstract

Development of a highly effective vaccine or antibodies for the prevention and ultimately elimination of malaria is urgently needed. Here we report the isolation of a number of human monoclonal antibodies directed against the Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP) from several subjects immunized with an attenuated Pf whole-sporozoite (SPZ) vaccine (Sanaria PfSPZ Vaccine). Passive transfer of one of these antibodies, monoclonal antibody CIS43, conferred high-level, sterile protection in two different mouse models of malaria infection. The affinity and stoichiometry of CIS43 binding to PfCSP indicate that there are two sequential multivalent binding events encompassing the repeat domain. The first binding event is to a unique 'junctional' epitope positioned between the N terminus and the central repeat domain of PfCSP. Moreover, CIS43 prevented proteolytic cleavage of PfCSP on PfSPZ. Analysis of crystal structures of the CIS43 antigen-binding fragment in complex with the junctional epitope determined the molecular interactions of binding, revealed the epitope's conformational flexibility and defined Asn-Pro-Asn (NPN) as the structural repeat motif. The demonstration that CIS43 is highly effective for passive prevention of malaria has potential application for use in travelers, military personnel and elimination campaigns and identifies a new and conserved site of vulnerability on PfCSP for next-generation rational vaccine design.

Published
2020

190. Prevention of tuberculosis in macaques after intravenous BCG immunization

Author

Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Koch Institute for Integrative Cancer Research at MIT, Darrah, Patricia A., Zeppa, Joseph J., Maiello, Pauline, Hackney, Joshua A., Wadsworth, Marc Havens, Hughes, Travis K., Pokkali, Supriya, Swanson II, Phillip A., Grant, Nicole L., Rodgers, Mark A., Kamath, Megha, Causgrove, Chelsea M., Laddy, Dominick J., Bonavia, Aurelio, Casimiro, Danilo, Lin, Philana Ling, Klein, Edwin, White, Alexander G., Scanga, Charles A., Shalek, Alexander K, Roederer, Mario, Flynn, JoAnne L., Seder, Robert A., Massachusetts Institute of Technology. Department of Chemistry, Massachusetts Institute of Technology. Institute for Medical Engineering & Science, Koch Institute for Integrative Cancer Research at MIT, Darrah, Patricia A., Zeppa, Joseph J., Maiello, Pauline, Hackney, Joshua A., Wadsworth, Marc Havens, Hughes, Travis K., Pokkali, Supriya, Swanson II, Phillip A., Grant, Nicole L., Rodgers, Mark A., Kamath, Megha, Causgrove, Chelsea M., Laddy, Dominick J., Bonavia, Aurelio, Casimiro, Danilo, Lin, Philana Ling, Klein, Edwin, White, Alexander G., Scanga, Charles A., Shalek, Alexander K, Roederer, Mario, Flynn, JoAnne L., and Seder, Robert A.

Abstract

Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide1. The only available vaccine, BCG (Bacillus Calmette–Guérin), is given intradermally and has variable efficacy against pulmonary tuberculosis, the major cause of mortality and disease transmission1,2. Here we show that intravenous administration of BCG profoundly alters the protective outcome of Mtb challenge in non-human primates (Macaca mulatta). Compared with intradermal or aerosol delivery, intravenous immunization induced substantially more antigen-responsive CD4 and CD8 T cell responses in blood, spleen, bronchoalveolar lavage and lung lymph nodes. Moreover, intravenous immunization induced a high frequency of antigen-responsive T cells across all lung parenchymal tissues. Six months after BCG vaccination, macaques were challenged with virulent Mtb. Notably, nine out of ten macaques that received intravenous BCG vaccination were highly protected, with six macaques showing no detectable levels of infection, as determined by positron emission tomography–computed tomography imaging, mycobacterial growth, pathology and granuloma formation. The finding that intravenous BCG prevents or substantially limits Mtb infection in highly susceptible rhesus macaques has important implications for vaccine delivery and clinical development, and provides a model for defining immune correlates and mechanisms of vaccine-elicited protection against tuberculosis.

Published
2020

192. Interferon gamma-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major

Author

Wang, Zhi-En, Zheng, Shichun, Corry, David B., Dalton, Dyana K., Seder, Robert A., Reiner, Steven L., and Locksley, Richard M.

Subjects
Interleukins -- Structure-activity relationships, CD4 lymphocytes -- Research, Science and technology
Abstract

Analysis of the immunologic effects of interleukin 12 (IL-12) injected into mice CD4+ cells at the time or after 14 days of Leishmania major-induced infection reveals that IL-12 inhibits IL-4 expression and incorporates IL-10 and interleukin gamma (INF-gamma) expression. IL-12 also induces IL-4 after 14 days of infection, indicating that the functions of IL-12 are independent of IL-4, IL-10 and IFN-gamma. IL-12 is ineffective in healing the infected mice, indicating that the T helper type 2 cells are resistive to the inhibition of IL-4 by IL-12.

Published
1994

193. Lymphocyte responses and cytokines

Author

Paul, William E. and Seder, Robert A.

Subjects
Cytokines -- Analysis, Lymphocytes -- Research, Macrophages -- Research, Autoimmunity -- Research, Biological sciences
Abstract

Cognate cellular interactions of CD4+ T cells determine their functions, including activation of T cell receptors. The numerous costimulatory ligand or receptor pairs represent cytokine-cytokine receptor interaction. Complex controls regulate the production of two types of cytokines responsible for cellular immunity and antibody production, respectively. The antigen dose is correlated to the development of immune response with characteristic cellular immunity or antibody production.

Published
1994

194. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming

Author

Seder, Robert A., Gazzinelli, Ricardo, Sher, Alan, and Paul, William E.

Subjects
Interleukins -- Analysis, T cells -- Analysis, Interferon -- Structure-activity relationships, Science and technology
Abstract

The function of IL-12 and IL-4 in antigen-specific priming was studied by employing T-cell receptor transgenic CD4+ T cells. IL-12 increased the capacity of CD4+ T cells to grow into cells producing 1FN-gamma following restimulation. IL-12 did not prevent priming for IL-4 synthesis in the presence of both IL-12 and IL-4. IL-12 has a prominent role to play in the inductive stage of T-cell priming, thus influencing the development of immunity factors.

Published
1993

195. Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement

Author

Toshio Tanaka, Hu-Li, Jane, Seder, Robert A., St. Groth, Barbara Fazekas de, and Paul, William E.

Subjects
Interleukin-4 -- Influence, Antigen receptors, T cell -- Analysis, Science and technology
Abstract

A study demonstrates that the acute generation interleukin 2(IL-1) and interferon-gamma (IFN-gamma) by naive CD4+ and CD8+ T cells in response to accessory cell-dependent activation with soluble anti-CD3 is strongly inhibited by IL-4. The IL-2 generation in response to antigen and antigen-presenting cells (APCs) of T cells from T-cell antigen receptor (TCR)-transgenic mice is inhibited by IL-4. IL-2 and IFN-gamma generation by primed T cells or T-cell clones or by naive T cells activated with phorbol ester and calcium ionophore in response to antigen plus APCs are not inhibited by IL-4.

Published
1993

198. DNA Vaccines

Author

Seder, Robert A. and Gurunathan, Sanjay.

Published
1999

200. Stochastic Expansions Maintain the Clonal Stability of CD8+ T Cell Populations Undergoing Memory Inflation Driven by Murine Cytomegalovirus

Author

Smith, Corinne J., primary, Venturi, Vanessa, additional, Quigley, Maire F., additional, Turula, Holly, additional, Gostick, Emma, additional, Ladell, Kristin, additional, Hill, Brenna J., additional, Himelfarb, Danielle, additional, Quinn, Kylie M., additional, Greenaway, Hui Yee, additional, Dang, Thurston H. Y., additional, Seder, Robert A., additional, Douek, Daniel C., additional, Hill, Ann B., additional, Davenport, Miles P., additional, Price, David A., additional, and Snyder, Christopher M., additional

Published
2020
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