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2,623 results on '"Schulz, C‐A"'

152. LBA11 IPSOS: Results from a phase III study of first-line (1L) atezolizumab (atezo) vs single-agent chemotherapy (chemo) in patients (pts) with NSCLC not eligible for a platinum-containing regimen

Author

Lee, S.M., primary, Schulz, C., additional, Prabhash, K., additional, Han, B., additional, Szczesna, A., additional, Cortinovis, D.L., additional, Rittmeyer, A., additional, Baz, D. Vicente, additional, Califano, R., additional, Anh, L. Tuan, additional, Liu, G., additional, Cappuzzo, F., additional, Contreras, J.G. Reyes, additional, Reck, M., additional, Hu, Y., additional, Morris, S., additional, Hoeglander, E.K., additional, Connors, M., additional, Vollan, H.K.M., additional, and Peters, S., additional

Published
2022
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166. Katecholamine

Author

Kopf, D., Schulz, C., Lehnert, H., Nawroth, Peter P., editor, and Ziegler, Reinhard, editor

Published
2001
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168. Ultrafast Dynamics in Na-doped water Clusters

Author

Liu, H. T., Müller, J. P., Schulz, C. P., SchrÖter, C., Zhavoronkov, N., Hertel, I. V., Corkum, Paul, editor, Silvestri, Sandro, editor, Nelson, Keith A., editor, Riedle, Eberhard, editor, and Schoenlein, Robert W., editor

Published
2009
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183. Author Correction: Femtosecond-resolved observation of the fragmentation of buckminsterfullerene following X-ray multiphoton ionization

Author

Berrah, N., Sanchez-Gonzalez, A., Jurek, Z., Obaid, R., Xiong, H., Squibb, R. J., Osipov, T., Lutman, A., Fang, L., Barillot, T., Bozek, J. D., Cryan, J., Wolf, T. J. A., Rolles, D., Coffee, R., Schnorr, K., Augustin, S., Fukuzawa, H., Motomura, K., Niebuhr, N., Frasinski, L. J., Feifel, R., Schulz, C. P., Toyota, K., Son, S.-K., Ueda, K., Pfeifer, T., Marangos, J. P., and Santra, R.

Published
2019
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187. Environmental signals rather than layered ontogeny imprint the function of type 2 conventional dendritic cells in young and adult mice

Author

Papaioannou, N.E., Salei, N., Rambichler, S., Ravi, K., Popovic, J., Küntzel, V., Lehmann, C.H.K., Fiancette, R., Salvermoser, J., Gajdasik, D.W., Mettler, R., Messerer, D., Carrelha, J., Ohnmacht, C., Haller, D., Stumm, R., Straub, T., Jacobsen, S.E.W., Schulz, C., Withers, D.R., Schotta, G., Dudziak, D., and Schraml, B.U.

Subjects
Male, T-Lymphocytes, Science, Primary Cell Culture, Antigen-presenting cells, Mice, Transgenic, Cell Separation, Adaptive Immunity, Article, Mice, Animals, RNA-Seq, ddc:610, Myelopoiesis, Age Factors, Gene Expression Regulation, Developmental, Cell Differentiation, Dendritic Cells, Flow Cytometry, Hematopoietic Stem Cells, Gene regulation in immune cells, Models, Animal, Cytokines, Female, Single-Cell Analysis, Transcriptome
Abstract

Conventional dendritic cells (cDC) are key activators of naive T cells, and can be targeted in adults to induce adaptive immunity, but in early life are considered under-developed or functionally immature. Here we show that, in early life, when the immune system develops, cDC2 exhibit a dual hematopoietic origin and, like other myeloid and lymphoid cells, develop in waves. Developmentally distinct cDC2 in early life, despite being distinguishable by fate mapping, are transcriptionally and functionally similar. cDC2 in early and adult life, however, are exposed to distinct cytokine environments that shape their transcriptional profile and alter their ability to sense pathogens, secrete cytokines and polarize T cells. We further show that cDC2 in early life, despite being distinct from cDC2 in adult life, are functionally competent and can induce T cell responses. Our results thus highlight the potential of harnessing cDC2 for boosting immunity in early life., Type 2 conventional dendritic cells (cDC2) are important immune activators in adults, but their development and functions at the neonatal stage remain unclear. Here the authors show, using fate-mapping and single-cell RNA sequencing, that neonatal cDC2 come from multiple origins, but converge functionally as potent immune activators upon proper stimuli.

Published
2021

189. Regulation of APD and force by Na+/Ca2+ exchanger in hiPSC-cardiomyocytes

Author

Ismaili, D, primary, Gurr, K, additional, Horvath, A, additional, Yuan, L, additional, Lemoine, MD, additional, Schulz, C, additional, Sani, J, additional, Petersen, J, additional, Reichenspurner, H, additional, Kirchhof, P, additional, Jespersen, T, additional, Eschenhagen, T, additional, Hansen, A, additional, Koivumaki, JT, additional, and Christ, T, additional

Published
2022
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193. Simulation of Spatially Developing Plane and Round Jets

Author

Comte, P., Dubief, Y., Brun, C., Meinke, M., Schulz, C., Rister, Th., Hirschel, Ernst Heinrich, editor, Fujii, Kozo, editor, Haase, Werner, editor, van Leer, Bram, editor, Leschziner, Michael A., editor, Pandolfi, Maurizio, editor, Rizzi, Arthur, editor, and Roux, Bernard, editor

Published
1998
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195. High prevalence of buccal ulcerations in largemouth bass, Micropterus salmoides (Centrarchidae) from Michigan inland lakes associated with Myzobdella lugubris Leidy 1851 (Annelida: Hirudinea)

Author

Faisal M., Schulz C., Eissa A., and Whelan G.

Subjects
Myzobdella lugubris, leech, Micropterus salmoides, buccal ulcerations, Infectious and parasitic diseases, RC109-216
Abstract

Widespread mouth ulcerations were observed in largemouth bass collected from eight inland lakes in the Lower Peninsula of Michigan during the summer months of 2002 and 2003. These ulcerations were associated with, and most likely caused by, leech parasitism. Through the use of morphological dichotomous keys, it was determined that all leeches collected are of one species: Myzobdella lugubris. Among the eight lakes examined, Lake Orion and Devils Lake had the highest prevalence of leech parasitism (34% and 29%, respectively) and mouth ulcerations (53% and 68%, respectively). Statistical analyses demonstrated that leech and ulcer prevalence varied significantly from one lake to the other. Additionally, it was determined that the relationship between the prevalence of ulcers and the prevalence of leech attachment is significant, indicating that leech parasitism is most likely the cause of ulceration. The ulcers exhibited deep hemorrhagic centers and raised irregular edges. Affected areas lost their epithelial lining and submucosa, with masses of bacteria colonizing the damaged tissues. Since largemouth bass is a popular global sportfish and critical to the food web of inland lakes, there are concerns that the presence of leeches, damaged buccal mucosa, and general unsightliness may negatively affect this important sportfishery.

Published
2011
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