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761 results on '"Schneider, Stefan W."'

154. Involvement of platelet-derived VWF in metastatic growth of melanoma in the brain

Author

Robador, Jose R, primary, Feinauer, Manuel J, additional, Schneider, Stefan W, additional, Mayer, Frank T, additional, Gorzelanny, Christian, additional, Sacharow, Artur, additional, Liu, Xiaobo, additional, Berghoff, Anna, additional, Brehm, Maria A, additional, Hirsch, Daniela, additional, Stadler, Julia, additional, Vidal-y-Si, Sabine, additional, Wladykowski, Ewa, additional, Asong, Marisse, additional, Nowak, Kai, additional, Seiz-Rosenhagen, Marcel, additional, Umansky, Viktor, additional, Mess, Christian, additional, Pantel, Klaus, additional, Winkler, Frank, additional, and Bauer, Alexander T, additional

Published
2021
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155. Real World Data on the Use of Nivolumab (Nivo) as Monotherapy or in Combination with Ipilimumab (Nivo plus Ipi) in the Treatment of advanced Melanoma : Interim Results of the non-interventional Study NICO

Author

Ugurel, Selma, Satzger, Imke, Eigentler, Thomas K., Mohr, Peter, Goeppner, Daniela, Herber, Matthew P., Herbst, Rudolf, Meier, F., Meiss, Frank, Pfohler, C., Sachse, Michael Max, Schneider, Stefan W., Terheyden, Patrick, Ulrich, Jens, Utikal, Jochen, Welzel, Julia, Schadendorf, Dirk, and Gutzmer, Ralf

Subjects
Medizin, ComputingMethodologies_GENERAL
Abstract

Poster Abstract

Published
2020

157. VI. Role of Capsaicin and transient receptor potential ion channels in the skin

Author

Roosterman, Dirk, Goerge, Tobias, Schneider, Stefan W., Bunnett, Nigel W., and Steinhoff, Martin

Subjects
Neurological research -- Research, Skin -- Research, Biological sciences, Health, Research
Abstract

Detailed information about TRP ion channels and their role in the skin can be found in other excellent reviews (70, 146, 147, 337, 453, 662, 805, 908) (Table 2). Sensory [...]

Published
2006

158. Neuronal control of skin function: the skin as a neuroimmunoendocrine organ

Author

Roosterman, Dirk, Goerge, Tobias, Schneider, Stefan W., Bunnett, Nigel W., and Steinhoff, Martin

Subjects
Skin diseases -- Care and treatment, Skin -- Health aspects, Biological sciences, Health, Care and treatment, Health aspects
Abstract

I. Introduction II. Anatomy and Physiology of the Cutaneous Nervous System A. Neuroanatomy and neurophysiology of cutaneous nerves B. The 'Skin-Sensory PNS-CNS connection' exemplified by itching C. Neuroanatomy and neurophysiology [...]

Published
2006

159. Margination and stretching of von Willebrand factor in the blood stream enable adhesion

Author

Rack, Kathrin, Huck, Volker, Hoore, Masoud, Fedosov, Dmitry A., Schneider, Stefan W., and Gompper, Gerhard

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Blood Cells, Movement, Computational science, lcsh:R, lcsh:Medicine, Models, Biological, Article, Biomechanical Phenomena, Computational biophysics, HEK293 Cells, Fluid dynamics, Lab-On-A-Chip Devices, hemic and lymphatic diseases, von Willebrand Factor, ddc:000, Cell Adhesion, cardiovascular system, Humans, lcsh:Q, Stress, Mechanical, lcsh:Science, Biological physics, Mechanical Phenomena, circulatory and respiratory physiology
Abstract

The protein von Willebrand factor (VWF) is essential in primary hemostasis, as it mediates platelet adhesion to vessel walls. VWF retains its compact (globule-like) shape in equilibrium due to internal molecular associations, but is able to stretch when a high enough shear stress is applied. Even though the shear-flow sensitivity of VWF conformation is well accepted, the behavior of VWF under realistic blood flow conditions remains poorly understood. We perform mesoscopic numerical simulations together with microfluidic experiments in order to characterize VWF behavior in blood flow for a wide range of flow-rate and hematocrit conditions. In particular, our results demonstrate that the compact shape of VWF is important for its migration (or margination) toward vessel walls and that VWF stretches primarily in a near-wall region in blood flow making its adhesion possible. Our results show that VWF is a highly optimized protein in terms of its size and internal associations which are necessary to achieve its vital function. A better understanding of the relevant mechanisms for VWF behavior in microcirculation provides a further step toward the elucidation of the role of mutations in various VWF-related diseases.

Published
2017

161. Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics

Author

Huck, Volker, primary, Chen, Po-Chia, primary, Xu, Emma-Ruoqi, primary, Tischer, Alexander, additional, Klemm, Ulrike, additional, Aponte-Santamaría, Camilo, additional, Mess, Christian, additional, Obser, Tobias, additional, Kutzki, Fabian, additional, König, Gesa, additional, Denis, Cécile V., additional, Gräter, Frauke, additional, Wilmanns, Matthias, additional, Auton, Matthew, additional, Schneider, Stefan W., additional, Schneppenheim, Reinhard, additional, Hennig, Janosch, additional, and Brehm, Maria A., additional

Published
2020
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164. DNA binds to a specific site of the adhesive blood-protein von Willebrand factor guided by electrostatic interactions

Author

Sandoval-Pérez, Angélica, primary, Berger, Ricarda M L, additional, Garaizar, Adiran, additional, Farr, Stephen E, additional, Brehm, Maria A, additional, König, Gesa, additional, Schneider, Stefan W, additional, Collepardo-Guevara, Rosana, additional, Huck, Volker, additional, Rädler, Joachim O, additional, and Aponte-Santamaría, Camilo, additional

Published
2020
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170. The electrical resistance breakdown assay determines the role of proteinases in tumor cell invasion

Author

Ludwig, Thomas, Ossig, Rainer, Graessel, Susanne, Wilhelmi, Marianne, Oberleithner, Hans, and Schneider, Stefan W.

Subjects
Tumors -- Growth, Electrophysiology -- Research, Cancer invasiveness -- Physiological aspects, Kidney cancer -- Physiological aspects, Metalloenzymes -- Physiological aspects, Biological sciences
Abstract

The electrical resistance breakdown of the Madin-Darby canine kidney (MDCK) cell monolayer provides a continuous assay system for cancer invasion that detects functional changes before morphological alterations. In this study, we address the question of whether physical contact between tumor cell and epithelial monolayer is a prerequisite for tumor cell invasion. When human melanoma cells were seeded directly (i.e., physical contact) on top of an electrically tight epithelial cell layer (5,800 [+ or -] 106 [ohms] * [cm.sup.2]), electrical monolayer leakage led to an 18 [+ or -] 3% reduction of transepithelial electrical resistance within 24 h. However, when melanoma cells were seeded close to the basolateral surface of the epithelial cell monolayer but separated by a filter membrane (i.e., no physical contact), electrical leakage occurred even more quickly (42 [+ or -] 3% reduction in 24 h). Atomic force microscopy detected discrete structural changes between cells. Electrical leakage was effectively blocked by [[alpha].sub.2]-macroglobulin or ilomastat, inhibitors of matrix metalloproteinases. We conclude that exocytosis of soluble proteases causes electrical breakdown of the MDCK monolayer, independently of physical contact between tumor cells and the monolayer. basement membrane; exocytosis; melanoma cells; ilomastat; matrix metalloproteinases

Published
2002

182. Upshaw-Schulman syndrome-associated ADAMTS13 variants possess proteolytic activity at the surface of endothelial cells and in simulated circulation

Author

Letzer, Anton, primary, Lehmann, Katja, additional, Mess, Christian, additional, König, Gesa, additional, Obser, Tobias, additional, Peine, Sven, additional, Schneppenheim, Sonja, additional, Budde, Ulrich, additional, Schneider, Stefan W., additional, Schneppenheim, Reinhard, additional, and Brehm, Maria A., additional

Published
2020
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183. Pre‐analytical factors affecting the establishment of a single tube assay for multiparameter liquid biopsy detection in melanoma patients

Author

Schneegans, Svenja, primary, Lück, Lelia, additional, Besler, Katharina, additional, Bluhm, Leonie, additional, Stadler, Julia‐Christina, additional, Staub, Janina, additional, Greinert, Rüdiger, additional, Volkmer, Beate, additional, Kubista, Mikael, additional, Gebhardt, Christoffer, additional, Sartori, Alexander, additional, Irwin, Darryl, additional, Serkkola, Elina, additional, Hällström, Taija, additional, Lianidou, Evi, additional, Sprenger‐Haussels, Markus, additional, Hussong, Melanie, additional, Mohr, Peter, additional, Schneider, Stefan W., additional, Shaffer, Jonathan, additional, Pantel, Klaus, additional, and Wikman, Harriet, additional

Published
2020
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199. No link between male infertility and HEV genotype 3 infection

Author

Horvatits, Thomas, primary, Varwig-Janssen, Domenica, additional, Schulze zur Wiesch, Julian, additional, Lübke, Rabea, additional, Reucher, Svenja, additional, Frerk, Sebastian, additional, Addo, Marylyn M, additional, Schneider, Stefan W, additional, Lohse, Ansgar W, additional, Luetgehetmann, Marc, additional, and Pischke, Sven, additional

Published
2019
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200. CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis

Author

Roblek, Marko, primary, Protsyuk, Darya, additional, Becker, Paul F., additional, Stefanescu, Cristina, additional, Gorzelanny, Christian, additional, Glaus Garzon, Jesus F., additional, Knopfova, Lucia, additional, Heikenwalder, Mathias, additional, Luckow, Bruno, additional, Schneider, Stefan W., additional, and Borsig, Lubor, additional

Published
2019
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