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162. Introduzione

Author

Magris, M., Musacchio, MARIA TERESA, Rega, L., and Scarpa, F.

Subjects
special languages, specialist translation, terminology, terminography
Published
2002

168. In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.

Author

Meraviglia, S, Eberl, M, Vermijlen, David, Todaro, M, Buccheri, S, Cicero, G, La Mendola, C, Guggino, G, D'Asaro, M, Orlando, V, Scarpa, F, Roberts, Allen, Caccamo, N, Stassi, G, Dieli, F, Hayday, A C, Meraviglia, S, Eberl, M, Vermijlen, David, Todaro, M, Buccheri, S, Cicero, G, La Mendola, C, Guggino, G, D'Asaro, M, Orlando, V, Scarpa, F, Roberts, Allen, Caccamo, N, Stassi, G, Dieli, F, and Hayday, A C

Abstract

The potent anti-tumour activities of gammadelta T cells have prompted the development of protocols in which gammadelta-agonists are administered to cancer patients. Encouraging results from small Phase I trials have fuelled efforts to characterize more clearly the application of this approach to unmet clinical needs such as metastatic carcinoma. To examine this approach in breast cancer, a Phase I trial was conducted in which zoledronate, a Vgamma9Vdelta2 T cell agonist, plus low-dose interleukin (IL)-2 were administered to 10 therapeutically terminal, advanced metastatic breast cancer patients. Treatment was well tolerated and promoted the effector maturation of Vgamma9Vdelta2 T cells in all patients. However, a statistically significant correlation of clinical outcome with peripheral Vgamma9Vdelta2 T cell numbers emerged, as seven patients who failed to sustain Vgamma9Vdelta2 T cells showed progressive clinical deterioration, while three patients who sustained robust peripheral Vgamma9Vdelta2 cell populations showed declining CA15-3 levels and displayed one instance of partial remission and two of stable disease, respectively. In the context of an earlier trial in prostate cancer, these data emphasize the strong linkage of Vgamma9Vdelta2 T cell status to reduced carcinoma progression, and suggest that zoledronate plus low-dose IL-2 offers a novel, safe and feasible approach to enhance this in a subset of treatment-refractory patients with advanced breast cancer., Clinical Trial, Phase I, Journal Article, Research Support, Non-U.S. Gov't, FLWIN, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2010

177. First record of Esox cisalpinus (Teleostea: Esocidae) in Sardinia with insight on its mitochondrial DNA genetic variability.

Author

Casu, M., Scarpa, F., Cossu, P., Lai, T., Curini-Galletti, M., Varcasia, A., and Sanna, D.

Subjects
*ESOCIDAE, *MITOCHONDRIAL DNA, *FISH genetics, *POPULATION dynamics
Abstract

Esox cisalpinus(Teleostea: Esocidae) (syn.Esox flaviae) is an Italian freshwater autochthonous fish, whose originary range is limited to the Northern and Central Italy. However, this species has historically been introduced in several areas of Southern Italy, mainly for recreational purposes. In this paper we report the first record ofE. cisalpinuson the Sardinia island (Western Mediterranean, Italy), where the species has been recently introduced at least in one lake. The species identification and the population dynamics analysis were performed using mitochondrial markers. The level of genetic variability, compared to those of other peninsular populations ofE. cisalpinus, was surprisingly high, and several never-before-described haplotypes were found. A total of 10 mtDNA haplotypes were found. Demographic analysis is suggestive of a population expansion. We hypothesise thatE. cisalpinushas been introduced in the Sardinian lake by the releasing of a conspicuous number of individuals. Given the conservational and recreational interest thatE. cisalpinusarouses, it would be advisable that Sardinian government focuses in the near future also on management measures of its Sardinian population. [ABSTRACT FROM AUTHOR]

Published
2016
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189. Cytochrome c oxidase subunit I variability in Ruditapes decussatus(Veneridae) from the western Mediterranean

Author

Sanna, D., Lai, T., Cossu, P., Scarpa, F., Dedola, G. L., Cristo, B., Francalacci, P., Curini-Galletti, M., Mura, L., Fois, N., Maltagliati, F., and Casu, M.

Abstract

AbstractRuditapes decussatus(Linnaeus, 1758) (Veneridae) is an Atlanto-Mediterranean bivalve whose populations have experienced reductions and, in some instances, hybridisation with allochthonous R. philippinarum. Acquisition of additional genetic knowledge concerning the present R. decussatuspopulations is essential to address adequate conservation plans for this species. For this purpose, we analysed a portion of the mtDNA cytochrome c oxidase subunit I (COI) region in populations from the western Mediterranean, where this species represents a harvested fishery resource. Our analyses revealed an overall lack of genetic structure within the western Mediterranean area, and the occurrence of mtDNA substructuring between the Aegean and Marmara seas and the remaining populations from the whole Mediterranean basin and the South European Atlantic coast. The results obtained for populations from Sardinia, where extensive restocking programmes have not been reported and where R. philippinarumis rare and localised, suggest that intensive harvesting and potential dispersal alone may have been able to shape the genetic variation identified in the local R. decussatuspopulations.

Published
2017
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