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4078 Background: To improve the poor prognosis of pts with MGC, we conducted a phase II study to evaluate the feasibility and efficacy of intensive NAC to enhance surgical respectability and survival. Methods: Eligible criteria included histologically proven metastatic or locally unserectable gastric adenocarcinoma and measurable or evaluable disease, PS 0–2 and sufficient organ functions. The primary endpoint was overall survival and the secondary endpoints were overall resonse rate (ORR) and toxicities. Since Oct. 2000, chemotherapy-naïve 120 pts with MGC have received S-1 (80 mg/m2 orally intake for 21 consecutive days) and CDDP (50 mg/m2 intravenous drip infusion on day 8) as NAC. Treatment was repeated every 5 weeks. The median administered courses were three (range: 1–7), and median follow up periods were 13.8 months. Results: The proportion of the duration as an outpatient- therapy was 86%. 77.5% of pts (93/120) went to surgical resection; 36 had distal gastrectomy and 57 had total gastrectomy. ORR was 62.5% (CR 1, PR 74), and 61.7%, 75.7%, 28.6% and 23.8% for primary lesion, metastatic lymph nodes, liver metastases and peritoneal metastasis, respectively. Toxicity (grade 3/4): neutropenia 7.5%, thrombocytopenia 6.7%, anemia 6.7%, anorexia 5.8%, nausea 2.5%; no treatment related death. Survival: median 23 months; 1 year 79%; 4 year 31% in all pts, and 42 months; 83%; 38% in pts with gastrectomy, respectively. In univariate analyses, overall survival (OS) was predicted by the responder, limited tumor location, H0, P0, but not by age, sex, histological type, gross type, T-factor, N-factor, or performance status. In multivariate analyses, H0, P0 and responder independently predicted OS. In pts with gastrectomy, H0, curative resection, PS0 and responder predicted OS. Conclusions: NAC with S-1 and CDDP was feasible and useful for pts with MGC and resulted in a promising survival rate. No significant financial relationships to disclose.

We here report a case of a 51-year-old man with lung metastasis from esophageal carcinoma that was initially treated by combination chemotherapy consisting of fluorouracil and nedaplatin. Because metastatic disease disappeared, salvage esophagectomy was performed. Although chest wall recurrence developed at the thoracotomy wound, prolonged survival of 48 months was achieved by local tumor resection and additional chemotherapy. This combination chemotherapy is regarded as a promising and considerable treatment for metastatic esophageal carcinoma.

A 10-year-old boy was injured in a traffic accident, and computed tomography revealed cavitary pulmonary lesions in the left lower lobe. Although there was no evidence of bacterial infection, thrombocytopenia due to disseminated intravascular coagulation progressed. We performed a left lower lobectomy, and the patient improved rapidly.

A New Criterion of Classification on Sudden Infant Death (Sid) Cases of Japan Sids Research Society

Statistical analysis is essential for the evaluation of biocompatibility, so we should section the bone with implant in place and prepare for examination by light microscopy. Hydroxyapatite coated composite had the best biocompatibility in both stainless steel and titanium alloy as a base alloy.

屋根瓦に用いられる粘土は通常真空土練押し出し成形機により成形され, 乾燥, 焼成される. この場合押し出し成形機による成形性は粘土の可塑性に影響される. 本報告では粘土の可塑性を押し出し成形機による成形性と関連付けてプラストグラフ曲線と応力-ひずみ曲線から評価した. プラストグラフ曲線は粘土に加えた水分によるコンシステンシーの変化から求めた. 応力-ひずみ曲線は円柱状に成形した粘土について圧縮試験で測定した. この実験で次の結果が得られた. 1) プラストグラフ曲線にピークが現れる場合, その粘土は押し出し成形機による成形が可能である. 2) 押し出し成形する場合プラストグラフ曲線の最大コンシステンシーを示す水分より多い水分で成形する必要がある. 3) ピークが現れない場合はプラストグラフ曲線だけでは成形の可否を決定できない. 4) 応力-ひずみ曲線は押し出し成形による成形性に有効な情報を与える. 5) 押し出し成形するには, 応力-ひずみ曲線から求めた最大応力が, 10mm径×10mm高さの試料で, 1.20kg以上, 最大変形量が1.8mm-2.0mmであることが必要である.

The microwave pulse excitation and subsequent relaxation of the tunneling Li + ion in KCl have been studied at 9.4 GHz, using the paraelectric resonance, the microwave saturation recovery and the microwave double resonance (MDR) developed newly. From the MDR, the absorption between A 2u - T 2g in the ground state tunneling quartet is expressed by a line with half-width of 0.6 GHz peaked at 8.5 GHz. The energy relaxation time T b depends on the thickness of specimen L and temperature T as T b (msec)≃ L (cm)· T ( K ). Abrupt decrease of T b is found when the specimen is immersed in He II. These data are explained in terms of the bottleneck effect of resonant phonon (RP) emitted from the microwave pumped system. The lifetime T ph of the RP is governed by its extinction at a two-level system on the surface with a rate of 0.01/reflection. The relation T b = T ph is derived after reducing the quartet to doublet.

In hemiarthroplasty of the hip, central migration, along with loosening and infection, is a critical complication affecting the prognosis. Using an experimental apparatus devised by the authors, which forces a dog to move its hip joints under load, wear of canine acetabular cartilage after alumina ceramic (Al2O2) or CoCrMo alloy hemiarthroplasty was examined.Cartilage surface wear on the CoCrMo alloy side was significantly higher than that on the ceramic side. The loading-time-related wear was more severe on the CoCrMo alloy side than on the ceramic side. This is due to low friction of ceramic head.Based on these results, it can be concluded that ceramic is preferable to CoCrMo alloy as a material for endoprostheses in terms of the effect on the acetabular cartilage.

The modified Lindgren oblique osteotomy on the first metatarsal was performed. From 1984 the operation has been performed on 23 feet in 18 patients. There was no complication. Two patients complained of metatarsalgia after the operation, but all other patients were satisfied after follow-up periods ranging from one and a half months to eleven months.

The properties of films formed on an iron surface by di-n-dodecyl phosphate were studied. The inhibition effects for iron specimens treated with dodecyl phosphate were estimated from the losses in weight of iron specimens in 5% NaCl aqueous solutions. The Fe Lα, Lβ X-ray emission spectra of the iron surface were obtained by electron microprobe X-ray analysis. The value of the intensity ratio, Fe Lβ/Lα, of the untreated iron specimen was 0.17, while that of the treated iron specimen was 0.28. The infrared spectrum of the treated iron surface was similar to that of tribasic orthophosphate. The content of Fe in the film formed on the iron surface by di-n-dodecyl phosphate was from 4.3% to 6.98%. From these results, it was inferred that di-n-dodecyl phosphate reacted with iron atoms at the iron surface in a cyclohexane solution and that the main component of the film formed on the iron surface was [(RO)2POO]2Fe or [(RO)2POO]3Fe.

The properties of films formed on an iron surface by di-n-dodecyl phosphate were studied. The inhibition effects for iron specimens treated with dodecyl phosphate were estimated from the losses in weight of iron specimens in 5% NaCl aqueous solutions. The Fe Lα, Lβ X-ray emission spectra of the iron surface were obtained by electron microprobe X-ray analysis. The value of the intensity ratio, Fe Lβ/Lα, of the untreated iron specimen was 0.17, while that of the treated iron specimen was 0.28. The infrared spectrum of the treated iron surface was similar to that of tribasic orthophosphate. The content of Fe in the film formed on the iron surface by di-n-dodecyl phosphate was from 4.3% to 6.98%. From these results, it was inferred that di-n-dodecyl phosphate reacted with iron atoms at the iron surface in a cyclohexane solution and that the main component of the film formed on the iron surface was [(RO)2POO]2Fe or [(RO)2POO]3Fe.

Serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, and squamous cell carcinoma (SCC) antigen levels were assessed to determine if their levels are useful for staging esophageal cancer preoperatively and for predicting patient survival after esophagectomy. Hence their seropositivity was investigated for a correlation with resectability, clinicopathologic parameters of tumor progression, and treatment outcomes in patients with unresectable esophageal cancer ( n = 63) and those undergoing esophagectomy for resectable disease ( n = 267). Abnormal elevation of serum SCC antigen levels showed a significant correlation with resectability ( p< 0.0001), depth of tumor invasion ( p < 0.0001), lymph node status ( p = 0.0015), TNM stage ( p < 0.0001), lymphatic invasion ( p = 0.0019), blood vessel invasion ( p = 0.0079), and poor survival after esophagectomy ( p = 0.0061). A significant relation ( p = 0.0145) was found between elevated serum CEA levels and distant metastasis, whereas the seropositivity of CA 19-9 showed no association with resectability, tumor progression, or patient survival. These results indicate that abnormal elevation of serum SCC antigen is a useful predictor of advanced esophageal cancer associated with poor survival after esophagectomy.

UV radiation characteristics of a pulsed discharge have been studied in atmospheric pressure. Experiments were carried out by changing the distance between the electrodes, the charging voltage of the capacitor, the resistance of the external circuit, and other features. It is shown that the optimum charging voltage and the gap distance are above 7 kV and above 5 mm, respectively.