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689 results on '"Santini E"'

181. Full Local Control With Accelerated Partial Breast Irradiation (APBI) by Tomotherapy After Breast-Conservative Surgery for Patients Suitable, or Not, According to ASTRO-2009 Consensus Statement: Interim Report After 2 Years Follow-Up

Author

de Paula, U., primary, D’Angelillo, R.M., additional, Caccavari, A., additional, Antonaci, A., additional, Barbara, R., additional, Cavaliere, F., additional, Costarelli, L., additional, La Pinta, M., additional, Loreti, A., additional, Mauri, M., additional, Santini, E., additional, Scavina, P., additional, and Fortunato, L., additional

Published
2014
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186. Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory

Author

Huynh, T N, Santini, E, Mojica, E, Fink, A E, Hall, B S, Fetcho, R N, Grosenick, L, Deisseroth, K, LeDoux, J E, Liston, C, and Klann, E

Abstract

Repeated presentations of a previously conditioned stimulus lead to a new form of learning known as extinction, which temporarily alters the response to the original stimulus. Previous studies have shown that the consolidation of extinction memory requires de novo protein synthesis. However, the role of specific nodes of translational control in extinction is unknown. Using auditory threat conditioning in mice, we investigated the role of mechanistic target of rapamycin complex 1 (mTORC1) and its effector p70 S6 kinase 1 (S6K1) in the extinction of auditory threat conditioning. We found that rapamycin attenuated the consolidation of extinction memory. In contrast, genetic deletion and pharmacological inhibition of S6K1, a downstream effector of mTORC1, blocked within-session extinction, indicating a role for S6K1 independent of protein synthesis. Indeed, the activation of S6K1 during extinction required extracellular signal-regulated kinase (ERK) activation in the basolateral nucleus of the amygdala (BLA) and was necessary for increased phosphorylation of the GluA1 (Thr840) subunit of the AMPA receptor following extinction training. Mice exposed to brief uncontrollable stress showed impaired within-session extinction as well as a downregulation of ERK and S6K1 signaling in the amygdala. Finally, using fiber photometry we were able to record calcium signals in vivo, and we found that inhibition of S6K1 reduces extinction-induced changes in neuronal activity of the BLA. These results implicate a novel ERK-S6K1-GluA1 signaling cascade critically involved in extinction.

Published
2018
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188. Gastric metastasis from renal cell carcinoma fourteen years after radical nephrectomy

Author

Marcello Picchio, Paioletti A, Santini E, Cordahi M, and Iacoponi S

Subjects
medicine.medical_specialty, Time Factors, medicine.medical_treatment, Nephrectomy, Metastasis, Renal cell carcinoma, Gastrectomy, Stomach Neoplasms, medicine, Carcinoma, Humans, Carcinoma, Renal Cell, Kidney, business.industry, Stomach, Biopsy, Needle, General Medicine, Middle Aged, medicine.disease, Kidney Neoplasms, Surgery, medicine.anatomical_structure, Treatment Outcome, Female, business, Kidney disease, Follow-Up Studies
Abstract

We report one case of solitary gastric metastasis from renal cell carcinoma following radical excision of the primary tumour 14 years previously. During evaluation for a severe anaemia with melaena, a patient underwent upper gastrointestinal endoscopy that evidenced the presence of a small polypoid lesion in the body of the stomach. Endoscopic biopsy revealed renal cell carcinoma. There was no evidence of further metastatic disease. A subtotal gastric resection with Roux-en-Y gastrojejunal reconstruction was performed. After 6 months follow-up, the patient was disease-free. This case confirms the potential of renal cell carcinoma for late and solitary metastasis with circumscribed local invasiveness and suggests that endoscopic resection may be feasible.

Published
2001

189. Sátira e humor em Machado de Assis: dois casos exemplares

Author

Rejane Cristina Rocha, Juliana Santini e and Rejane Cristina Rocha, Juliana Santini e

Abstract

This article promotes a compared analysis between “O caso da vara” e QuincasBorba, by Machado de Assis, observing the way by wich satire and humor areinserted in the aesthetic project of the author, especially in the configurationof a “realism of evaluation”. Narrator and focalization construct a criticaldimension by the mean of the comical forms mentioned, visualizing the “minorsocial interval” that, in according to Alfredo Bosi, characterizes BrazilianRealism under Machado de Assis., Este artigo promove uma análise comparada entre o conto “O caso da vara” eo romance Quincas Borba, de Machado de Assis, observando de que modo asátira e o humor inserem-se no projeto estético machadiano no que diz respeitoà configuração de um “realismo de avaliação”. Nos dois textos, narrador efocalização projetam uma dimensão crítica por meio das formas do cômicomencionadas, permitindo visualizar a composição do “intervalo social menor”que, segundo Alfredo Bosi, caracteriza o Realismo brasileiro sob Machado deAssis.

Published
2009

190. Accelerated partial breast irradiation (APBI) with tomotherapy HI-ART on 85 patients treated at San Giovanni-Addolorata Hospital Rome: Preliminary report

Author

De Paula, U., primary, Muni, R., additional, Renato, A., additional, Adriana, A., additional, Barbara, R., additional, Caccavari, A., additional, Costarelli, L., additional, Di Palma, A., additional, Loreti, A., additional, Mauri, M., additional, Petrocchi, A., additional, Santini, E., additional, Scavina, P., additional, and Fortunato, L., additional

Published
2013
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191. THU0304 Gross Cystic Disease Fluid Protein-15(GCDFP-15)/Prolactin-Inducible Protein (PIP): A Functional Salivary Biomarker for Primary SjöGren’s Syndrome?

Author

Baldini, C., primary, Martini, D., additional, Sernissi, F., additional, Gallo, A., additional, Rossi, C., additional, Mosca, M., additional, Santini, E., additional, Pepe, P., additional, Solini, A., additional, Perez, P., additional, Alevizos, I., additional, and Bombardieri, S., additional

Published
2013
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