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151. Constraints on the neutrino emission from the Galactic Ridge with the ANTARES telescope

Author

Adrián-Martínez, S., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Avgitas, T., Baret, B., Barrios-Martí, J., Basa, S., Bertin, V., Biagi, S., Bormuth, R., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Celli, S., Chiarusi, T., Circella, M., Coleiro, A., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Deschamps, A., De Bonis, G., Distefano, C., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., Bojaddaini, I. El, Elsässer, D., Enzenhöfer, A., Fehn, K., Felis, I., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Glotin, H., Gracia-Ruiz, R., Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Hugon, C., Illuminati, G., James, C. W, de Jong, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lachaud, C., Lahmann, R., Lefèvre, D., Leonora, E., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mathieu, A., Michael, T., Migliozzi, P., Moussa, A., Mueller, C., Nezri, E., Păvălaş, G. E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Roensch, K., Saldaña, M., Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Sapienza, P., Schnabel, J., Schüssler, F., Seitz, T., Sieger, C., Spurio, M., Stolarczyk, Th., Taiuti, M., Trovato, A., Tselengidou, M., Turpin, D., Tönnis, C., Vallage, B., Vallée, C., Van Elewyck, V., Visser, E., Vivolo, D., Wagner, S., Wilms, J., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Compelling evidence for the existence of astrophysical neutrinos has been reported by the IceCube collaboration. Some features of the energy and declination distributions of IceCube events hint at a North/South asymmetry of the neutrino flux. This could be due to the presence of the bulk of our Galaxy in the Southern hemisphere. The ANTARES neutrino telescope, located in the Mediterranean Sea, has been taking data since 2007. It offers the best sensitivity to muon neutrinos produced by galactic cosmic ray interactions in this region of the sky. In this letter a search for an extended neutrino flux from the Galactic Ridge region is presented. Different models of neutrino production by cosmic ray propagation are tested. No excess of events is observed and upper limits for different neutrino flux spectral indices are set. This constrains the number of IceCube events possibly originating from the Galactic Ridge. A simple power-law extrapolation of the Fermi-LAT flux to associated IceCube High Energy Starting Events is excluded at 90% confidence level.

Published
2016
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152. Letter of Intent for KM3NeT 2.0

Author

Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E., Andre, M., Androulakis, G., Anghinolfi, M., Anton, G., Ardid, M., Avgitas, T., Barbarino, G., Barbarito, E., Baret, B., Barrios-Martí, J., Belhorma, B., Belias, A., Berbee, E., Berg, A. van den, Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Billault, M., Bond, M., Bormuth, R., Bouhadef, B., Bourlis, G., Bourret, S., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Buis, E., Busto, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Cecchini, S., Celli, S., Champion, C., Moursli, R. Cherkaoui El, Cherubini, S., Chiarusi, T., Circella, M., Classen, L., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colonges, S., Coniglione, R., Cordelli, M., Cosquer, A., Coyle, P., Creusot, A., Cuttone, G., D'Amico, A., De Bonis, G., De Rosa, G., De Sio, C., Di Capua, F., Di Palma, I., García, A. F. Díaz, Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durocher, M., Eberl, T., Eichie, S., van Eijk, D., Bojaddaini, I. El, Khayati, N. El, Elsaesser, D., Enzenhöfer, A., Fassi, F., Favali, P., Fermani, P., Ferrara, G., Frascadore, G., Filippidis, C., Fusco, L. A., Gal, T., Galatà, S., Garufi, F., Gay, P., Gebyehu, M., Giordano, V., Gizani, N., Gracia, R., Graf, K., Grégoire, T., Grella, G., Habel, R., Hallmann, S., van Haren, H., Harissopulos, S., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Hevinga, M., Hofestädt, J., Hugon, C. M. F., Illuminati, G., James, C. W., Jansweijer, P., Jongen, M., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U. F., Keller, P., Kieft, G., Kießling, D., Koffeman, E. N., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Lamare, P., Leisos, A., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C. D. Llorens, Presti, D. Lo, Löhner, H., Lonardo, A., Lotze, M., Loucatos, S., Maccioni, E., Mannheim, K., Margiotta, A., Marinelli, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Mele, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Mijakowski, P., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Moussa, A., Musico, P., Musumeci, M., Navas, S., Nicolau, C. A., Olcina, I., Olivetto, C., Orlando, A., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrino, C., Perrina, C., Pfutzner, M., Piattelli, P., Pikounis, K., Poma, G. E., Popa, V., Pradier, T., Pratolongo, F., Pühlhofer, G., Pulvirenti, S., Quinn, L., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rossi, C., Rovelli, A., Saldaña, M., Salvadori, I., Samtleben, D. F. E., García, A. Sánchez, Losa, A. Sánchez, Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schimmel, F., Schmelling, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Spisso, B., Spurio, M., Stavropoulos, G., Steijger, J., Stellacci, S. M., Stransky, D., Taiuti, M., Tayalati, Y., Tézier, D., Theraube, S., Thompson, L., Timmer, P., Tönnis, C., Trasatti, L., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vicini, P., Viola, S., Vivolo, D., Volkert, M., Voulgaris, G., Wiggers, L., Wilms, J., de Wolf, E., Zachariadou, K., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

The main objectives of the KM3NeT Collaboration are i) the discovery and subsequent observation of high-energy neutrino sources in the Universe and ii) the determination of the mass hierarchy of neutrinos. These objectives are strongly motivated by two recent important discoveries, namely: 1) The high-energy astrophysical neutrino signal reported by IceCube and 2) the sizable contribution of electron neutrinos to the third neutrino mass eigenstate as reported by Daya Bay, Reno and others. To meet these objectives, the KM3NeT Collaboration plans to build a new Research Infrastructure consisting of a network of deep-sea neutrino telescopes in the Mediterranean Sea. A phased and distributed implementation is pursued which maximises the access to regional funds, the availability of human resources and the synergetic opportunities for the earth and sea sciences community. Three suitable deep-sea sites are identified, namely off-shore Toulon (France), Capo Passero (Italy) and Pylos (Greece). The infrastructure will consist of three so-called building blocks. A building block comprises 115 strings, each string comprises 18 optical modules and each optical module comprises 31 photo-multiplier tubes. Each building block thus constitutes a 3-dimensional array of photo sensors that can be used to detect the Cherenkov light produced by relativistic particles emerging from neutrino interactions. Two building blocks will be configured to fully explore the IceCube signal with different methodology, improved resolution and complementary field of view, including the Galactic plane. One building block will be configured to precisely measure atmospheric neutrino oscillations., Comment: 119 pages, published version, revised Eq. 6, 7

Published
2016
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153. Assessment methodology for human-exoskeleton interactions: Kinetic analysis based on muscle activation

Author

Vasco Fanti, Vittorio Sanguineti, Darwin G. Caldwell, Jesús Ortiz, and Christian Di Natali

Subjects
assistance, emg-to-force processing, exoskeletons, human-robot interaction, kinematic, kinetic, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

During the development and assessment of an exoskeleton, many different analyzes need to be performed. The most frequently used evaluate the changes in muscle activations, metabolic consumption, kinematics, and kinetics. Since human-exoskeleton interactions are based on the exchange of forces and torques, the latter of these, kinetic analyzes, are essential and provide indispensable evaluation indices. Kinetic analyzes, however, require access to, and use of, complex experimental apparatus, involving many instruments and implicating lengthy data analysis processes. The proposed methodology in this paper, which is based on data collected via EMG and motion capture systems, considerably reduces this burden by calculating kinetic parameters, such as torque and power, without needing ground reaction force measurements. This considerably reduces the number of instruments used, allows the calculation of kinetic parameters even when the use of force sensors is problematic, does not need any dedicated software, and will be shown to have high statistical validity. The method, in fact, combines data found in the literature with those collected in the laboratory, allowing the analysis to be carried out over a much greater number of cycles than would normally be collected with force plates, thus enabling easy access to statistical analysis. This new approach evaluates the kinetic effects of the exoskeleton with respect to changes induced in the user's kinematics and muscular activation patterns and provides indices that quantify the assistance in terms of torque (AMI) and power (API). Following the User-Center Design approach, which requires driving the development process as feedback from the assessment process, this aspect is critical. Therefore, by enabling easy access to the assessment process, the development of exoskeletons could be positively affected.

Published
2022
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154. Stereotactic partial breast irradiation in primary breast cancer: A comprehensive review of the current status and future directions

Author

Silvia Takanen, Paola Pinnarò, Ilaria Farina, Francesca Sperati, Claudio Botti, Patrizia Vici, Antonella Soriani, Laura Marucci, and Giuseppe Sanguineti

Subjects
breast cancer, stereotactic partial breast radiotherapy, local toxicity, SBRT, breast cosmesis, APBI, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

In selected low-risk breast cancer patients, accelerated partial breast irradiation (APBI) may represent an alternative option to the whole breast irradiation to reduce the volume of irradiated breast and total treatment duration. In the last few years, preliminary data from clinical trials showed that stereotactic partial breast radiotherapy may have the advantage to be less invasive compared to other APBI techniques, with preliminary good results in terms of local toxicity and cosmesis: the use of magnetic resonance, fiducial markers in the tumor bed, and new breast devices support both a precise definition of the target and radiation planning.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021257856, identifier CRD42021257856.

Published
2022
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155. Sex‐Specific Considerations in Degenerative Aortic Stenosis for Female‐Tailored Transfemoral Aortic Valve Implantation Management

Author

Giulia Masiero, Valeria Paradies, Anna Franzone, Barbara Bellini, Chiara De Biase, Nicole Karam, Francesca Sanguineti, Mamas A. Mamas, Hélène Eltchaninoff, Chiara Fraccaro, Battistina Castiglioni, Tiziana Attisano, Giovanni Esposito, and Alaide Chieffo

Subjects
aortic stenosis, clinical management, device selection, sex differences, transcatheter aortic valve implantation, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The impact of sex on pathophysiological processes, clinical presentation, treatment options, as well as outcomes of degenerative aortic stenosis remain poorly understood. Female patients are well represented in transfemoral aortic valve implantation (TAVI) trials and appear to derive favorable outcomes with TAVI. However, higher incidences of major bleeding, vascular complications, and stroke have been reported in women following TAVI. The anatomical characteristics and pathophysiological features of aortic stenosis in women might guide a tailored planning of the percutaneous approach. We highlight whether a sex‐based TAVI management strategy might impact on clinical outcomes. This review aimed to evaluate the impact of sex from diagnosis to treatment of degenerative aortic stenosis, discussing the latest evidence on epidemiology, pathophysiology, clinical presentation, therapeutic options, and outcomes. Furthermore, we focused on technical sex‐oriented considerations in TAVI including the preprocedural screening, device selection, implantation strategy, and postprocedural management.

Published
2022
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156. Additional prognostic value of stress cardiovascular magnetic resonance for cardiovascular risk stratification after a cryptogenic ischemic stroke

Author

Solenn Toupin, Théo Pezel, Francesca Sanguineti, Marine Kinnel, Thomas Hovasse, Thierry Unterseeh, Stéphane Champagne, Philippe Garot, and Jérôme Garot

Subjects
cardiovascular magnetic resonance (CMR) imaging, cardiovascular events (CVE), stroke, stress testing cardiac imaging, ischemia, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundOne-third of ischemic strokes are “cryptogenic” without clearly identified etiology. Although coronary artery disease (CAD) is the main cause of death after stroke, the interest in CAD screening in patients with cryptogenic stroke is still debated.AimThe aim of the study was to assess the incremental prognostic value of stress cardiovascular magnetic resonance (CMR) beyond traditional risk factors for predicting cardiovascular events in patients with a prior cryptogenic ischemic stroke.Materials and methodsBetween 2008 and 2021, consecutive patients with prior cryptogenic strokes referred for stress CMR were included and followed for the occurrence of major adverse cardiovascular events (MACEs), defined by cardiovascular death or non-fatal myocardial infarction (MI). Univariable and multivariable Cox regressions were performed to determine the prognostic value of unrecognized MI and silent ischemia.ResultsOf 542 patients (55.2% male, mean age 71.4 ± 8.8 years) who completed the follow-up (median 5.9 years), 66 (12.2%) experienced MACE. Silent ischemia and unrecognized MI were detected in 18 and 17% of patients, respectively. Using Kaplan–Meier analysis, silent ischemia and unrecognized MI were associated with the occurrence of MACE [hazard ratio, HR: 8.43 (95% CI: 5.11–13.9); HR: 7.87 (95% CI: 4.80–12.9), respectively, p < 0.001]. In multivariable analysis, silent ischemia and unrecognized MI were independent predictors of MACE [HR: 8.08 (95% CI: 4.21–15.5); HR: 6.65 (95% CI: 3.49–12.7), respectively, p < 0.001]. After adjustment, stress CMR findings showed the best improvement in model discrimination and reclassification above traditional risk factors (C-statistic improvement: 0.13; NRI = 0.428; IDI = 0.048).ConclusionIn patients with prior cryptogenic stroke, stress CMR findings have an incremental prognostic value to predict MACE over traditional risk factors.

Published
2022
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157. God in the Face of Natural and Moral Evils: A Thomistic Approach

Author

Juan José Sanguineti

Subjects
physical evil, moral evil, life, animal pain, aggression, human person, Religions. Mythology. Rationalism, BL1-2790
Abstract

The existence of evil in a world created by God raises very difficult questions to answer. Under the inspiration of Thomistic philosophy, in this article we face this problem first of all “from below”, trying to understand the meaning of physical evils in living nature, especially in animals (pain, aggressive interactions). Secondly, in thinking of the enormous amount of moral evil in the human world, we consider the biblical faith in original sin as illuminating. We examine some points of Thomas Aquinas in this regard, especially his thesis that the physical cosmos is not affected by original sin and that the loss of man’s primitive happy situation involves a contradiction between his spiritual aspirations and his mortal nature subject to limits and suffering. This situation is remedied by the help God gives man through his ordinary Providence, which includes a personal struggle against evil, and above all through his salvific plan which we know thanks to the biblical faith.

Published
2023
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158. Prognostic value of vasodilator stress perfusion cardiovascular magnetic resonance after inconclusive stress testing

Author

Théo Pezel, Thierry Unterseeh, Philippe Garot, Thomas Hovasse, Marine Kinnel, Stéphane Champagne, Solenn Toupin, Francesca Sanguineti, and Jérôme Garot

Subjects
Cardiovascular magnetic resonance, Stress testing, Inconclusive stress test, Cardiovascular events, Dipyridamole, Revascularization, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background While current guidelines recommend noninvasive testing to detect coronary artery disease, stress tests are deemed inconclusive in a quarter of cases. The strategy for risk stratification after inconclusive stress testing is not well standardized. To assess the prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) parameters and CMR-based coronary revascularization in patients after inconclusive stress testing. Methods Between 2008 and 2020, consecutive patients with a first non-CMR inconclusive stress test referred for vasodilator stress perfusion CMR were followed for the occurrence of major adverse cardiovascular events (MACE), defined by cardiovascular death or nonfatal myocardial infarction. CMR-related coronary revascularization was defined as any revascularisation occurring within 90 days after CMR. Univariable and multivariable Cox regressions were performed to determine the prognostic value of each parameter. Results Of 1563 patients who completed the CMR protocol, 1402 patients (66.7% male, 69.5 ± 11.0 years) completed the follow-up (median [interquartile range], 6.5 [5.6–7.5] years); 197 experienced a MACE (14.1%). Vasodilator stress CMR was well tolerated without severe adverse events. Using Kaplan–Meier analysis, inducible ischemia and late gadolinium enhancement (LGE) were significantly associated with the occurrence of MACE (hazard ratio, HR: 2.88 [95% CI 2.18–3.81]; and HR: 1.46 [95% CI 1.16–1.89], both p

Published
2021
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159. The prognostic relevance of HER2-positivity gain in metastatic breast cancer in the ChangeHER trial

Author

Laura Pizzuti, Maddalena Barba, Marco Mazzotta, Eriseld Krasniqi, Marcello Maugeri-Saccà, Teresa Gamucci, Rossana Berardi, Lorenzo Livi, Corrado Ficorella, Clara Natoli, Enrico Cortesi, Daniele Generali, Nicla La Verde, Alessandra Cassano, Emilio Bria, Luca Moscetti, Andrea Michelotti, Vincenzo Adamo, Claudio Zamagni, Giuseppe Tonini, Domenico Sergi, Daniele Marinelli, Giancarlo Paoletti, Silverio Tomao, Andrea Botticelli, Paolo Marchetti, Nicola Tinari, Antonino Grassadonia, Maria Rosaria Valerio, Rosanna Mirabelli, Maria Agnese Fabbri, Nicola D’Ostilio, Enzo Veltri, Domenico Corsi, Ornella Garrone, Ida Paris, Giuseppina Sarobba, Icro Meattini, Mirco Pistelli, Francesco Giotta, Vito Lorusso, Carlo Garufi, Antonio Russo, Marina Cazzaniga, Pietro Del Medico, Mario Roselli, Angela Vaccaro, Letizia Perracchio, Anna di Benedetto, Theodora Daralioti, Isabella Sperduti, Ruggero De Maria, Angelo Di Leo, Giuseppe Sanguineti, Gennaro Ciliberto, and Patrizia Vici

Subjects
Medicine, Science
Abstract

Abstract In metastatic breast cancer (mBC), the change of human epidermal growth factor receptor 2 (HER2) status between primary and metastatic lesions is widely recognized, however clinical implications are unknown. Our study address the question if relevant differences exist between subjects who preserve the HER2 status and those who gain the HER2 positivity when relapsed. Data of patients affected by HER2-positive mBC, treated with pertuzumab and/or trastuzumab-emtansine (T-DM1) in a real-world setting at 45 Italian cancer centers were retrospectively collected and analyzed. From 2003 to 2017, 491 HER2‐positive mBC patients were included. Of these, 102 (20.7%) had been initially diagnosed as HER2-negative early BC. Estrogen and/or progesterone receptor were more expressed in patients with HER2-discordance compared to patients with HER2-concordant status (p

Published
2021
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160. Organ motion in linac-based SBRT for glottic cancer

Author

Annarita Perillo, Valeria Landoni, Alessia Farneti, and Giuseppe Sanguineti

Subjects
Organ motion, Daily CBCT imaging, SBRT, Glottic cancer, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Purpose The purpose of this study is to evaluate inter- and intra-fraction organ motion as well as to quantify clinical target volume (CTV) to planning target volume (PTV) margins to be adopted in the stereotactic treatment of early stage glottic cancer. Methods and materials Stereotactic body radiotherapy (SBRT) to 36 Gy in 3 fractions was administered to 23 patients with early glottic cancer T1N0M0. Patients were irradiated with a volumetric intensity modulated arc technique delivered with 6 MV FFF energy. Each patient underwent a pre-treatment cone beam computed tomography (CBCT) to correct the setup based on the thyroid cartilage position. Imaging was repeated if displacement exceeded 2 mm in any direction. CBCT imaging was also performed after each treatment arc as well as at the end of the delivery. Swallowing was allowed only during the beam-off time between arcs. CBCT images were reviewed to evaluate inter- and intra-fraction organ motion. The relationships between selected treatment characteristics, both beam-on and delivery times as well as organ motion were investigated. Results For the population systematic (Ʃ) and random (σ) inter-fraction errors were 0.9, 1.3 and 0.6 mm and 1.1, 1.3 and 0.7 mm in the left-right (X), cranio-caudal (Y) and antero-posterior (Z) directions, respectively. From the analysis of CBCT images acquired after treatment, systematic (Ʃ) and random (σ) intra-fraction errors resulted 0.7, 1.6 and 0.7 mm and 1.0, 1.5 and 0.6 mm in the X, Y and Z directions, respectively. Margins calculated from the intra-fraction errors were 2.4, 5.1 and 2.2 mm in the X, Y and Z directions respectively. A statistically significant difference was found for the displacement in the Z direction between patients irradiated with > 2 arcs versus ≤ 2 arcs, (MW test, p = 0.038). When analyzing mean data from CBCT images for the whole treatment, a significant correlation was found between the time of delivery and the three dimensional displacement vector (r = 0.489, p = 0.055), the displacement in the Y direction (r = 0.553, p = 0.026) and the subsequent margins to be adopted (r = 0.626, p = 0.009). Finally, displacements and the subsequent margins to be adopted in Y direction were significantly greater for treatments with more than 2 arcs (MW test p = 0.037 and p = 0.019, respectively). Conclusions In the setting of controlled swallowing during treatment delivery, intra-fraction motion still needs to be taken into account when planning with estimated CTV to PTV margins of 3, 5 and 3 mm in the X, Y and Z directions, respectively. Selected treatments may require additional margins.

Published
2021
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161. Methodologies to Increase the Level of Evidence of Real-life Proton Therapy in Head and Neck Tumors

Author

Francesco Dionisi, MD, Lamberto Widesott, PhD, Van VulpenMarco, MD, Clifton David Fuller, MD, Rocco Frondizi, PhD, Marco Meneguzzo, Pierre Blanchard, MD, Maurizio Amichetti, MD, and Giuseppe Sanguineti, MD

Subjects
proton therapy, head and neck cancer, randomized trials, model-based approach, registries, Medical physics. Medical radiology. Nuclear medicine, R895-920, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

This review aims to present and assess available and new methodologies to increase the clinical evidence of proton therapy data for patients with head and neck cancer. Despite the increasing number of scientific reports showing the feasibility and effectiveness of proton therapy in head and neck cancer, clinical evidence on the potential benefits of its use remains low for several reasons. In this article, the pros and cons of consolidated and new methodologies in this setting such as randomized clinical trials, the model-based approach, and the use of prospective multicentric registries will be detailed.

Published
2021
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162. Search for non-standard neutrino interactions with 10 years of ANTARES data

Author

Albert, A., Alves, S., André, M., Anghinolfi, M., Anton, G., Ardid, M., Ardid, S., Aubert, J.-J., Aublin, J., Baret, B., Basa, S., Belhorma, B., Bendahman, M., Benfenati, F., Bertin, V., Biagi, S., Bissinger, M., Boumaaza, J., Bouta, M., Bouwhuis, M. C., Brânzaş, H., Bruijn, R., Brunner, J., Busto, J., Caiffi, B., Calvo, D., Capone, A., Caramete, L., Carr, J., Carretero, V., Celli, S., Chabab, M., Chau, T. N., Cherkaoui El Moursli, R., Chiarusi, T., Circella, M., Coleiro, A., Coniglione, R., Coyle, P., Creusot, A., Díaz, A. F., de Wasseige, G., Distefano, C., Di Palma, I., Domi, A., Donzaud, C., Dornic, D., Drouhin, D., Eberl, T., van Eeden, T., van Eijk, D., El Khayati, N., Enzenhöfer, A., Fermani, P., Ferrara, G., Filippini, F., Fusco, L., Gatelet, Y., Gay, P., Glotin, H., Gozzini, R., Gracia Ruiz, R., Graf, K., Guidi, C., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Huang, F., Illuminati, G., James, C. W., Jisse-Jung, B., de Jong, M., de Jong, P., Kadler, M., Kalekin, O., Katz, U., Khan-Chowdhury, N. R., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Le Breton, R., LeStum, S., Lefèvre, D., Leonora, E., Levi, G., Lincetto, M., Lopez-Coto, D., Loucatos, S., Maderer, L., Manczak, J., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Martino, B., Melis, K., Migliozzi, P., Moussa, A., Muller, R., Nauta, L., Navas, S., Nezri, E., Fearraigh, B. Ó, Păun, A., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Poirè, C., Popa, V., Pradier, T., Randazzo, N., Real, D., Reck, S., Riccobene, G., Romanov, A., Sánchez-Losa, A., Salesa Greus, F., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schnabel, J., Schumann, J., Schüssler, F., Seneca, J., Spurio, M., Stolarczyk, Th., Taiuti, M., Tayalati, Y., Thakore, T., Tingay, S. J., Vallage, B., Van Elewyck, V., Versari, F., Viola, S., Vivolo, D., Wilms, J., Zavatarelli, S., Zegarelli, A., Zornoza, J. D., and Zúñiga, J.

Published
2022
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164. Proton therapy in the treatment of hepatocellular carcinoma

Author

Francesco Dionisi, Daniele Scartoni, Francesco Fracchiolla, Irene Giacomelli, Benedetta Siniscalchi, Lucia Goanta, Marco Cianchetti, Giuseppe Sanguineti, and Alberto Brolese

Subjects
proton therapy, hepatocellular carcinoma, active scanning, photon therapy, review, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Liver cancer represents one of the most common causes of death from cancer worldwide. Hepatocellular carcinoma (HCC) accounts for 90% of all primary liver cancers. Among local therapies, evidence regarding the use of radiation therapy is growing. Proton therapy currently represents the most advanced radiation therapy technique with unique physical properties which fit well with liver irradiation. Here, in this review, we aim to 1) illustrate the rationale for the use of proton therapy (PT) in the treatment of HCC, 2) discuss the technical challenges of advanced PT in this disease, 3) review the major clinical studies regarding the use of PT for HCC, and 4) analyze the potential developments and future directions of PT in this setting.

Published
2022
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166. La construcción de un nuevo Derecho Transnacional del Trabajo para las cadenas globales de valor

Author

Wilfredo Sanguineti Raymond

Subjects
Derecho transnacional del trabajo, Cadenas de valor globales, Law, International relations, JZ2-6530
Abstract

El texto constituye una versión abreviada de la ponencia general sobre el tema comercio internacional y trabajo, presentada al XXIII Congreso Mundial de la Sociedad Internacional de Derecho del Trabajo y de la Seguridad Social, celebrado en Lima entre el 7 y el 10 de septiembre de 2021. La misma constituye el resultado final de un largo proceso de reflexión desarrollado en el marco del Grupo Internacional de Investigación sobre Comercio Internacional y Trabajo, cuya coordinación fue encomendada al autor en septiembre de 2019 por dicha institución con el objeto de promover la investigación colaborativa en torno a este tema, uno de los siete a ser abordados en el referido congreso. Su elaboración forma parte de las actividades del Proyecto de Investigación “La construcción transnacional del Derecho del Trabajo: de la pirámide a la red. La contribución española” (TRANSLAB Ref. PID2019-104809-100-DER).

Published
2022

167. First combined search for neutrino point-sources in the Southern Hemisphere with the ANTARES and IceCube neutrino telescopes

Author

ANTARES Collaboration, Adrián-Martínez, S., Albert, A., André, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios-Martí, J., Basa, S., Bertin, V., Biagi, S., Bormuth, R., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Chiarusi, T., Circella, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Dekeyser, I., Deschamps, A., De Bonis, G., Distefano, C., Donzaud, C., Dornic, D., Drouhin, D., Dumas, A., Eberl, T., Elsässer, D., Enzenhöfer, A., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gracia-Ruiz, R., Graf, K., Hallmann, S., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Hößl, J., Hofestädt, J., Hugon, C., James, C. W, de Jong, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kreter, M., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lefèvre, D., Leonora, E., Loucatos, S., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Mathieu, A., Michael, T., Migliozzi, P., Moussa, A., Mueller, C., Nezri, E., Păvălaş, G. E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Saldaña, M., Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Sapienza, P., Schmid, J., Schnabel, J., Schüssler, F., Seitz, T., Sieger, C., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Taiuti, M., Tamburini, C., Trovato, A., Tselengidou, M., Tönnis, C., Vallage, B., Vallée, C., Van Elewyck, V., Visser, E., Vivolo, D., Wagner, S., Wilms, J., Zornoza, J. D., Zúñiga, J., Collaboration, IceCube, Aartsen, M. G., Abraham, K., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., Altmann, D., Anderson, T., Ansseau, I., Archinger, M., Arguelles, C., Arlen, T. C., Auffenberg, J., Bai, X., Barwick, S. W., Baum, V., Bay, R., Beatty, J. J., Tjus, J. Becker, Becker, K. -H., Beiser, E., Berghaus, P., Berley, D., Bernardini, E., Bernhard, A., Besson, D. Z., Binder, G., Bindig, D., Bissok, M., Blaufuss, E., Blumenthal, J., Boersma, D. J., Bohm, C., Börner, M., Bos, F., Bose, D., Böser, S., Botner, O., Braun, J., Brayeur, L., Bretz, H. -P., Buzinsky, N., Casey, J., Casier, M., Cheung, E., Chirkin, D., Christov, A., Clark, K., Classen, L., Coenders, S., Cowen, D. F., Silva, A. H. Cruz, Daughhetee, J., Davis, J. C., Day, M., de André, J. P. A. M., De Clercq, C., Rosendo, E. del Pino, Dembinski, H., De Ridder, S., Desiati, P., de Vries, K. D., de Wasseige, G., de With, M., DeYoung, T., Díaz-Vélez, J. C., di Lorenzo, V., Dumm, J. P., Dunkman, M., Eberhardt, B., Ehrhardt, T., Eichmann, B., Euler, S., Evenson, P. A., Fahey, S., Fazely, A. R., Feintzeig, J., Felde, J., Filimonov, K., Finley, C., Fischer-Wasels, T., Flis, S., Fösig, C. -C., Fuchs, T., Gaisser, T. K., Gaior, R., Gallagher, J., Gerhardt, L., Ghorbani, K., Gier, D., Gladstone, L., Glagla, M., Glüsenkamp, T., Goldschmidt, A., Golup, G., Gonzalez, J. G., Góra, D., Grant, D., Griffith, Z., Groß, A., Ha, C., Haack, C., Ismail, A. Haj, Hallgren, A., Halzen, F., Hansen, E., Hansmann, B., Hanson, K., Hebecker, D., Heereman, D., Helbing, K., Hellauer, R., Hickford, S., Hignight, J., Hill, G. C., Hoffman, K. D., Hoffmann, R., Holzapfel, K., Homeier, A., Hoshina, K., Huang, F., Huber, M., Huelsnitz, W., Hulth, P. O., Hultqvist, K., In, S., Ishihara, A., Jacobi, E., Japaridze, G. S., Jero, K., Jurkovic, M., Kappes, A., Karg, T., Karle, A., Kauer, M., Keivani, A., Kelley, J. L., Kemp, J., Kheirandish, A., Kiryluk, J., Kläs, J., Klein, S. R., Kohnen, G., Koirala, R., Kolanoski, H., Konietz, R., Köpke, L., Kopper, C., Kopper, S., Koskinen, D. J., Kowalski, M., Krings, K., Kroll, G., Kroll, M., Krückl, G., Kunnen, J., Kurahashi, N., Kuwabara, T., Labare, M., Lanfranchi, J. L., Larson, M. J., Lesiak-Bzdak, M., Leuermann, M., Leuner, J., Lu, L., Lünemann, J., Madsen, J., Maggi, G., Mahn, K. B. M., Mandelartz, M., Maruyama, R., Mase, K., Matis, H. S., Maunu, R., McNally, F., Meagher, K., Medici, M., Meli, A., Menne, T., Merino, G., Meures, T., Miarecki, S., Middell, E., Mohrmann, L., Montaruli, T., Morse, R., Nahnhauer, R., Naumann, U., Neer, G., Niederhausen, H., Nowicki, S. C., Nygren, D. R., Obertacke, A., Pollmann, Olivas, A., Omairat, A., O'Murchadha, A., Palczewski, T., Pandya, H., Pankova, D. V., Paul, L., Pepper, J. A., Heros, C. Pérez de los, Pfendner, C., Pieloth, D., Pinat, E., Posselt, J., Price, P. B., Przybylski, G. T., Pütz, J., Quinnan, M., Raab, C., Rädel, L., Rameez, M., Rawlins, K., Reimann, R., Relich, M., Resconi, E., Rhode, W., Richman, M., Richter, S., Riedel, B., Robertson, S., Rongen, M., Rott, C., Ruhe, T., Ryckbosch, D., Sabbatini, L., Sander, H. -G., Sandrock, A., Sandroos, J., Sarkar, S., Schatto, K., Scheriau, F., Schimp, M., Schmidt, T., Schmitz, M., Schoenen, S., Schöneberg, S., Schönwald, A., Schulte, L., Schumacher, L., Seckel, D., Seunarine, S., Soldin, D., Song, M., Spiczak, G. M., Spiering, C., Stahlberg, M., Stamatikos, M., Stanev, T., Stasik, A., Steuer, A., Stezelberger, T., Stokstad, R. G., Stößl, A., Ström, R., Strotjohann, N. L., Sullivan, G. W., Sutherland, M., Taavola, H., Taboada, I., Tatar, J., Ter-Antonyan, S., Terliuk, A., Tešić, G., Tilav, S., Toale, P. A., Tobin, M. N., Toscano, S., Tosi, D., Turcati, A., Unger, E., Usner, M., Vallecorsa, S., Vandenbroucke, J., van Eijndhoven, N., Vanheule, S., van Santen, J., Veenkamp, J., Vehring, M., Voge, M., Vraeghe, M., Walck, C., Wallace, A., Wallraff, M., Wandkowsky, N., Weaver, Ch., Wendt, C., Westerhoff, S., Whelan, B. J., Wiebe, K., Wiebusch, C. H., Wille, L., Williams, D. R., Wissing, H., Wolf, M., Wood, T. R., Woschnagg, K., Xu, D. L., Xu, X. W., Xu, Y., Yanez, J. P., Yodh, G., Yoshida, S., and Zoll, M.

Subjects
High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena
Abstract

We present the results of searches for point-like sources of neutrinos based on the first combined analysis of data from both the ANTARES and IceCube neutrino telescopes. The combination of both detectors which differ in size and location forms a window in the Southern sky where the sensitivity to point sources improves by up to a factor of two compared to individual analyses. Using data recorded by ANTARES from 2007 to 2012, and by IceCube from 2008 to 2011, we search for sources of neutrino emission both across the Southern sky and from a pre-selected list of candidate objects. No significant excess over background has been found in these searches, and flux upper limits for the candidate sources are presented for $E^{-2.5}$ and $E^{-2}$ power-law spectra with different energy cut-offs., Comment: 25 pages, 9 figures. Submitted to ApJ

Published
2015
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168. The prototype detection unit of the KM3NeT detector

Author

KM3NeT Collaboration, Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Androulakis, G. C., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Avgitas, T., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Barrios, J., Belias, A., Berbee, E., Berg, A. M. van den, Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Biagioni, A., Bianucci, S., Billault, M., Birbas, A., Rookhuizen, H. Boer, Bormuth, R., Bouché, V., Bouhadef, B., Bourlis, G., Boutonnet, C., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Château, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Coleiro, A., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Di Capua, F., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Elsaesser, D., Enzenhöfer, A., Fermani, P., Fusco, L. A., Gajanana, D., Gal, T., Galatà, S., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., GraciaRuiz, R., Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernández-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestädt, J., Hogenbirk, J., Hugon, C., Hößl, J., Imbesi, M., James, C. W., Jansweijer, P., Jochum, J., de Jong, M., Jongen, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Provost, H. Le, Leismüller, K. P., Leisos, A., Lenis, D., Leonora, E., LindseyClark, M., Alvarez, C. D. Llorens, Löhner, H., Lonardo, A., Loucatos, S., Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Mariş, O., Markou, C., Martínez-Mora, J. A., Martini, A., Masullo, R., Melis, K. W., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papaikonomou, A., Papaleo, R., Păvălaş, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, Th., Priede, M., Pühlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Saldaña, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Schmelling, J., Schnabel, J., Sciacca, V., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Sipala, V., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tézier, D., Théraube, S., Thompson, L. F., Timmer, P., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Vicini, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Zonca, E., Zornoza, J. D., Zúñiga, J., and Zwart, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment, Physics - Instrumentation and Detectors
Abstract

A prototype detection unit of the KM3NeT deep-sea neutrino telescope has been installed at 3500m depth 80km offshore the Italian coast. KM3NeT in its final configuration will contain several hundreds of detection units. Each detection unit is a mechanical structure anchored to the sea floor, held vertical by a submerged buoy and supporting optical modules for the detection of Cherenkov light emitted by charged secondary particles emerging from neutrino interactions. This prototype string implements three optical modules with 31 photomultiplier tubes each. These optical modules were developed by the KM3NeT Collaboration to enhance the detection capability of neutrino interactions. The prototype detection unit was operated since its deployment in May 2014 until its decommissioning in July 2015. Reconstruction of the particle trajectories from the data requires a nanosecond accuracy in the time calibration. A procedure for relative time calibration of the photomultiplier tubes contained in each optical module is described. This procedure is based on the measured coincidences produced in the sea by the 40K background light and can easily be expanded to a detector with several thousands of optical modules. The time offsets between the different optical modules are obtained using LED nanobeacons mounted inside them. A set of data corresponding to 600 hours of livetime was analysed. The results show good agreement with Monte Carlo simulations of the expected optical background and the signal from atmospheric muons. An almost background-free sample of muons was selected by filtering the time correlated signals on all the three optical modules. The zenith angle of the selected muons was reconstructed with a precision of about 3{\deg}., Comment: Accepted for publication by EPJ C

Published
2015
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169. Optical and X-ray early follow-up of ANTARES neutrino alerts

Author

Adrian-Martinez, S., Ageron, M., Albert, A., Samarai, I. Al, Andre, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios-Marti, J., Basa, S., Bertin, V., Biagi, S., Bogazzi, C., Bormuth, R., Bou-Cabo, M., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Chiarusi, T., Circella, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Dekeyser, I., Deschamps, A., De Bonis, G., Distefano, C., Donzaud, C., Dornic, D., Drouhin, D., Dumas, A., Eberl, T., Elsasser, D., Enzenhofer, A., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galata, S., Gay, P., Geißelsoder, S., Geyer, K., Giordano, V., Gleixner, A., Gracia-Ruiz, R., Graf, K., van Haren, H., Heijboer, A. J., Hello, Y., Hernandez-Rey, J. J., Herrero, A., Hoßl, J., Hofestadt, J., Hugon, C., James, C. W, de Jong, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lambard, G., Lattuada, D., Lefevre, D., Leonora, E., Loucatos, S., Mangano, S., Marcelin, M., Margiotta, A., Martinez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Moussa, A., Mueller, C., Neff, M., Nezri, E., Pavalas, G. E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Rostovtsev, A., Saldana, M., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schmid, J., Schnabel, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Sanchez-Losa, A., Taiuti, M., Tamburini, C., Trovato, A., Tselengidou, M., Tonnis, C., Turpin, D., Vallage, B., Vallee, C., Van Elewyck, V., Vecchi, M., Visser, E., Vivolo, D., Wagner, S., Wilms, J., Zornoza, J. D., Zuniga, J., Klotz, A., Boer, M., Van Suu, A. Le, Akerlof, C., Zheng, W., Evans, P., Gehrels, N., Kennea, J., Osborne, J. P., and Coward, D. M.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

High-energy neutrinos could be produced in the interaction of charged cosmic rays with matter or radiation surrounding astrophysical sources. Even with the recent detection of extraterrestrial high-energy neutrinos by the IceCube experiment, no astrophysical neutrino source has yet been discovered. Transient sources, such as gamma-ray bursts, core-collapse supernovae, or active galactic nuclei are promising candidates. Multi-messenger programs offer a unique opportunity to detect these transient sources. By combining the information provided by the ANTARES neutrino telescope with information coming from other observatories, the probability of detecting a source is enhanced, allowing the possibility of identifying a neutrino progenitor from a single detected event. A method based on optical and X-ray follow-ups of high-energy neutrino alerts has been developed within the ANTARES collaboration. This program, denoted as TAToO, triggers a network of robotic optical telescopes (TAROT and ROTSE) and the Swift-XRT with a delay of only a few seconds after a neutrino detection, and is therefore well-suited to search for fast transient sources. To identify an optical or X-ray counterpart to a neutrino signal, the images provided by the follow-up observations are analysed with dedicated pipelines. A total of 42 alerts with optical and 7 alerts with X-ray images taken with a maximum delay of 24 hours after the neutrino trigger have been analysed. No optical or X-ray counterparts associated to the neutrino triggers have been found, and upper limits on transient source magnitudes have been derived. The probability to reject the gamma-ray burst origin hypothesis has been computed for each alert.

Published
2015
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170. Long term monitoring of the optical background in the Capo Passero deep-sea site with the NEMO tower prototype

Author

Adrián-Martínez, S., Aiello, S., Ameli, F., Anghinolfi, M., Ardid, M., Barbarino, G., Barbarito, E., Barbato, F. C. T., Beverini, N., Biagi, S., Biagioni, A., Bouhadef, B., Bozza, C., Cacopardo, G., Calamai, M., Calí, C., Calvo, D., Capone, A., Caruso, F., Ceres, A., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Costa, M., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Luca, V., Deniskina, N., De Rosa, G., di Capua, F., Distefano, C., Enzenhöfer, A., Fermani, P., Ferrara, G., Flaminio, V., Fusco, L. A., Garufi, F., Giordano, V., Gmerk, A., Grasso, R., Grella, G., Hugon, C., Imbesi, M., Kulikovskiy, V., Lahmann, R., Larosa, G., Lattuada, D., Leismüller, K. P., Leonora, E., Litrico, P., Alvarez, C. D. Llorens, Lonardo, A., Longhitano, F., Presti, D. Lo, Maccioni, E., Margiotta, A., Marinelli, A., Martini, A., Masullo, R., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Orzelli, A., Papaleo, R., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pugliatti, C., Pulvirenti, S., Raffaelli, F., Randazzo, N., Real, D., Riccobene, G., Rovelli, A., Saldaña, M., Sanguineti, M., Sapienza, P., Sciacca, V., Sgura, I., Simeone, F., Sipala, V., Speziale, F., Spitaleri, A., Spurio, M., Stellacci, S. M., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Ventura, C., Vicini, P., Viola, S., and Vivolo, D.

Subjects
Physics - Instrumentation and Detectors
Abstract

The NEMO Phase-2 tower is the first detector which was operated underwater for more than one year at the "record" depth of 3500 m. It was designed and built within the framework of the NEMO (NEutrino Mediterranean Observatory) project. The 380 m high tower was successfully installed in March 2013 80 km offshore Capo Passero (Italy). This is the first prototype operated on the site where the italian node of the KM3NeT neutrino telescope will be built. The installation and operation of the NEMO Phase-2 tower has proven the functionality of the infrastructure and the operability at 3500 m depth. A more than one year long monitoring of the deep water characteristics of the site has been also provided. In this paper the infrastructure and the tower structure and instrumentation are described. The results of long term optical background measurements are presented. The rates show stable and low baseline values, compatible with the contribution of 40K light emission, with a small percentage of light bursts due to bioluminescence. All these features confirm the stability and good optical properties of the site., Comment: 12 pages, 17 figures

Published
2015
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171. Time calibration with atmospheric muon tracks in the ANTARES neutrino telescope

Author

Adrián-Martínez, S., Albert, A., André, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios-Martí, J., Basa, S., Bertin, V., Biagi, S., Bogazzi, C., Bormuth, R., Bou-Cabo, M., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Chiarusi, T., Circella, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Dekeyser, I., Deschamps, A., De Bonis, G., Distefano, C., Donzaud, C., Dornic, D., Drouhin, D., Dumas, A., Eberl, T., Elsässer, D., Enzenhöfer, A., Fehn, K., Felis, I., Fermani, P., Flaminio, V., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gracia-Ruiz, R., Gómez-González, J. P., Graf, K., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Herrero, A., Hößl, J., Hofestädt, J., Hugon, C., James, C. W, de Jong, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R, Lambard, G., Lattuada, D., Lefèvre, D., Leonora, E., Loucatos, S., Mangano, S., Marcelin, M., Margiotta, A., Marinelli, A., Martínez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Moussa, A., Mueller, C., Neff, M., Nezri, E., Păvălaş, G. E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Rostovtsev, A., Saldaña, M., Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Sapienza, P., Schmid, J., Schnabel, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Taiuti, M., Tamburini, C., Trovato, A., Tselengidou, M., Tönnis, C., Turpin, D., Vallage, B., Vallée, C., Van Elewyck, V., Visser, E., Vivolo, D., Wagner, S., Wilms, J., Zornoza, J. D., and Zúñiga, J.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The ANTARES experiment consists of an array of photomultipliers distributed along 12 lines and located deep underwater in the Mediterranean Sea. It searches for astrophysical neutrinos collecting the Cherenkov light induced by the charged particles, mainly muons, produced in neutrino interactions around the detector. Since at energies of $\sim$10 TeV the muon and the incident neutrino are almost collinear, it is possible to use the ANTARES detector as a neutrino telescope and identify a source of neutrinos in the sky starting from a precise reconstruction of the muon trajectory. To get this result, the arrival times of the Cherenkov photons must be accurately measured. A to perform time calibrations with the precision required to have optimal performances of the instrument is described. The reconstructed tracks of the atmospheric muons in the ANTARES detector are used to determine the relative time offsets between photomultipliers. Currently, this method is used to obtain the time calibration constants for photomultipliers on different lines at a precision level of 0.5 ns. It has also been validated for calibrating photomultipliers on the same line, using a system of LEDs and laser light devices., Comment: Submitted to Astroparticle Physics (17 pages, 11 figures)

Published
2015
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172. Search for muon-neutrino emission from GeV and TeV gamma-ray flaring blazars using five years of data of the ANTARES telescope

Author

Adrián-Martínez, S., Albert, A., André, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios-Martí, J., Basa, S., Bertin, V., Biagi, S., Bogazzi, C., Bormuth, R., Bou-Cabo, M., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Chiarusi, T., Circella, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Dekeyser, I., Deschamps, A., De Bonis, G., Distefano, C., Donzaud, C., Dornic, D., Drouhin, D., Dumas, A., Eberl, T., Elsässer, D., Enzenhöfer, A., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gracia-Ruiz, R., Graf, K., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Herrero, A., Hößl, J., Hofestädt, J., Hugon, C., James, C. W, de Jong, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lambard, G., Lattuada, D., Lefèvre, D., Leonora, E., Loucatos, S., Mangano, S., Margiotta, A., Martínez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Moussa, A., Mueller, C., Neff, M., Nezri, E., Păvălaş, G. E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Rostovtsev, A., Saldaña, M., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schmid, J., Schnabel, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Sánchez-Losa, A., Taiuti, M., Tamburini, C., Trovato, A., Tselengidou, M., Tönnis, C., Turpin, D., Vallage, B., Vallée, C., Van Elewyck, V., Visser, E., Vivolo, D., Wagner, S., Wilms, J., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The ANTARES telescope is well-suited for detecting astrophysical transient neutrino sources as it can observe a full hemisphere of the sky at all times with a high duty cycle. The background due to atmospheric particles can be drastically reduced, and the point-source sensitivity improved, by selecting a narrow time window around possible neutrino production periods. Blazars, being radio-loud active galactic nuclei with their jets pointing almost directly towards the observer, are particularly attractive potential neutrino point sources, since they are among the most likely sources of the very high-energy cosmic rays. Neutrinos and gamma rays may be produced in hadronic interactions with the surrounding medium. Moreover, blazars generally show high time variability in their light curves at different wavelengths and on various time scales. This paper presents a time-dependent analysis applied to a selection of flaring gamma-ray blazars observed by the FERMI/LAT experiment and by TeV Cherenkov telescopes using five years of ANTARES data taken from 2008 to 2012. The results are compatible with fluctuations of the background. Upper limits on the neutrino fluence have been produced and compared to the measured gamma-ray spectral energy distribution., Comment: 27 pages, 16 figures

Published
2015
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173. Search of Dark Matter Annihilation in the Galactic Centre using the ANTARES Neutrino Telescope

Author

ANTARES Collaboration, Adrián-Martínez, S., Albert, A., André, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios-Martí, J., Basa, S., Bertin, V., Biagi, S., Bogazzi, C., Bormuth, R., Bou-Cabo, M., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Chiarusi, T., Circella, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., Dekeyser, I., Deschamps, A., DeBonis, G., Distefano, C., Donzaud, C., Dornic, D., Drouhin, D., Dumas, A., Eberl, T., Elsässer, D., Enzenhöfer, A., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gracia-Ruiz, R., Graf, K., vanHaren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Herrero, A., Hößl, J., Hofestädt, J., Hugon, C., WJames, C., deJong, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lambard, G., Lattuada, D., Lefèvre, D., Leonora, E., Loucatos, S., Marcelin, M., Margiotta, A., Martínez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Moussa, A., Mueller, C., Neff, M., Nezri, E., Păvălaş, G. E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Rostovtsev, A., Saldaña, M., Samtleben, D. F. E., Sanguineti, M., Sapienza, P., Schmid, J., Schnabel, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Sánchez-Losa, A., Taiuti, M., Tamburini, C., Trovato, A., Tselengidou, M., Tönnis, C., Vallage, B., Vallée, C., VanElewyck, V., Visser, E., Vivolo, D., Wagner, S., Wilms, J., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Astrophysics of Galaxies, High Energy Physics - Phenomenology
Abstract

A search for high-energy neutrinos coming from the direction of the Galactic Centre is performed using the data recorded by the ANTARES neutrino telescope from 2007 to 2012. The event selection criteria are chosen to maximise the sensitivity to possible signals produced by the self-annihilation of weakly interacting massive particles accumulated around the centre of the Milky Way with respect to the atmospheric background. After data unblinding, the number of neutrinos observed in the line of sight of the Galactic Centre is found to be compatible with background expectations. The 90% C.L. upper limits in terms of the neutrino+anti-neutrino flux, $\rm \Phi_{\nu_{\mu}+\bar{\nu}_\mu}$, and the velocity averaged annihilation cross-section, $\rm <\sigma_{A}v>$, are derived for the WIMP self-annihilation channels into $\rm b\bar{b},W^{+}W^{-},\tau^{+}\tau^{-},\mu^{+}\mu^{-},\nu\bar{\nu}$. The ANTARES limits for $\rm <\sigma_{A}v>$ are shown to be the most stringent for a neutrino telescope over the WIMP masses $\rm 25\,GeV < M_{WIMP} < 10\,TeV$., Comment: 26 pages, 12 figures, 4 tables

Published
2015
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174. ANTARES Constrains a Blazar Origin of Two IceCube PeV Neutrino Events

Author

ANTARES Collaboration, Adrián-Martínez, S., Albert, A., André, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios, J., Basa, S., Bertin, V., Biagi, S., Bogazzi, C., Bormuth, R., Bou-Cabo, M., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Chiarusi, T., Circella, M., Coniglione, R., Costantini, H., Coyle, P., Creusot, A., De Rosa, G., Dekeyser, I., Deschamps, A., De Bonis, G., Distefano, C., Donzaud, C., Dornic, D., Dorosti, Q., Drouhin, D., Dumas, A., Eberl, T., Enzenhöfer, A., Escoffier, S., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gómez-González, J. P., Gracia-Ruiz, R., Graf, K., Guillard, G., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Herrero, A., Hößl, J., Hofestädt, J., Hugon, C., James, C. W, de Jong, M., Kalekin, O., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kulikovskiy, V., Lahmann, R., Lefèvre, D., Leonora, E., Loehner, H., Loucatos, S., Mangano, S., Marcelin, M., Margiotta, A., Martínez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Neff, M., Nezri, E., Palioselitis, D., Păvălaş, G. E., Pellegrino, C., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Rostovtsev, A., Saldaña, M., Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Sapienza, P., Schmid, J., Schnabel, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spies, A., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Taiuti, M., Tamburini, C., Tayalati, Y., Trovato, A., Tselengidou, M., Tönnis, C., Vallage, B., Vallée, C., Van Elewyck, V., Visser, E., Vivolo, D., Wagner, S., de Wolf, E., Yepes, H., Zornoza, J. D., Zúñiga, J., Collaboration, TANAMI, Krauß, F., Kadler, M., Mannheim, K., Schulz, R., Trüstedt, J., Wilms, J., Ojha, R., Ros, E., Baumgartner, W., Beuchert, T., Blanchard, J., Bürkel, C., Carpenter, B., Edwards, P. G., Glawion, D. Eisenacher, Elsässer, D., Fritsch, U., Gehrels, N., Gräfe, C., Großberger, C., Hase, H., Horiuchi, S., Kappes, A., Kreikenbohm, A., Kreykenbohm, I., Langejahn, M., Leiter, K., Litzinger, E., Lovell, J. E. J., Müller, C., Phillips, C., Plötz, C., Quick, J., Steinbring, T., Stevens, J., Thompson, D. J., and Tzioumis, A. K.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

The source(s) of the neutrino excess reported by the IceCube Collaboration is unknown. The TANAMI Collaboration recently reported on the multiwavelength emission of six bright, variable blazars which are positionally coincident with two of the most energetic IceCube events. Objects like these are prime candidates to be the source of the highest-energy cosmic rays, and thus of associated neutrino emission. We present an analysis of neutrino emission from the six blazars using observations with the ANTARES neutrino telescope.The standard methods of the ANTARES candidate list search are applied to six years of data to search for an excess of muons --- and hence their neutrino progenitors --- from the directions of the six blazars described by the TANAMI Collaboration, and which are possibly associated with two IceCube events. Monte Carlo simulations of the detector response to both signal and background particle fluxes are used to estimate the sensitivity of this analysis for different possible source neutrino spectra. A maximum-likelihood approach, using the reconstructed energies and arrival directions of through-going muons, is used to identify events with properties consistent with a blazar origin.Both blazars predicted to be the most neutrino-bright in the TANAMI sample (1653$-$329 and 1714$-$336) have a signal flux fitted by the likelihood analysis corresponding to approximately one event. This observation is consistent with the blazar-origin hypothesis of the IceCube event IC14 for a broad range of blazar spectra, although an atmospheric origin cannot be excluded. No ANTARES events are observed from any of the other four blazars, including the three associated with IceCube event IC20. This excludes at a 90\% confidence level the possibility that this event was produced by these blazars unless the neutrino spectrum is flatter than $-2.4$., Comment: 15 pages, 3 figures, 2 tables

Published
2015
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175. The KM3NeT potential for the next core-collapse supernova observation with neutrinos

Author

S. Aiello, A. Albert, S. Alves Garre, Z. Aly, A. Ambrosone, F. Ameli, M. Andre, G. Androulakis, M. Anghinolfi, M. Anguita, G. Anton, M. Ardid, S. Ardid, J. Aublin, C. Bagatelas, B. Baret, S. Basegmez du Pree, M. Bendahman, F. Benfenati, E. Berbee, A. M. van den Berg, V. Bertin, S. Biagi, M. Bissinger, M. Boettcher, M. Bou Cabo, J. Boumaaza, M. Bouta, M. Bouwhuis, C. Bozza, H. Brânzaş, R. Bruijn, J. Brunner, E. Buis, R. Buompane, J. Busto, B. Caiffi, D. Calvo, A. Capone, V. Carretero, P. Castaldi, S. Celli, M. Chabab, N. Chau, A. Chen, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, M. Colomer Molla, R. Coniglione, P. Coyle, A. Creusot, G. Cuttone, R. Dallier, B. De Martino, M. De Palma, M. Di Marino, I. Di Palma, A. F. Díaz, D. Diego-Tortosa, C. Distefano, A. Domi, C. Donzaud, D. Dornic, M. Dörr, D. Drouhin, T. Eberl, A. Eddyamoui, T. van Eeden, D. van Eijk, I. El Bojaddaini, D. Elsaesser, A. Enzenhöfer, V. Espinosa, P. Fermani, G. Ferrara, M. D. Filipović, F. Filippini, L. A. Fusco, O. Gabella, T. Gal, A. Garcia Soto, F. Garufi, Y. Gatelet, N. Geißelbrecht, L. Gialanella, E. Giorgio, S. R. Gozzini, R. Gracia, K. Graf, D. Grasso, G. Grella, D. Guderian, C. Guidi, J. Haefner, H. Hamdaoui, H. van Haren, A. Heijboer, A. Hekalo, L. Hennig, J. J. Hernández-Rey, J. Hofestädt, F. Huang, W. Idrissi Ibnsalih, G. Illuminati, C. W. James, M. de Jong, P. de Jong, B. J. Jung, M. Kadler, P. Kalaczyński, O. Kalekin, U. F. Katz, N. R. Khan Chowdhury, G. Kistauri, F. van der Knaap, P. Kooijman, A. Kouchner, M. Kreter, V. Kulikovskiy, R. Lahmann, M. Lamoureux, G. Larosa, R. Le Breton, S. Le Stum, O. Leonardi, F. Leone, E. Leonora, N. Lessing, G. Levi, M. Lincetto, M. Lindsey Clark, T. Lipreau, F. Longhitano, D. Lopez-Coto, L. Maderer, J. Mańczak, K. Mannheim, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J. A. Martínez-Mora, A. Martini, F. Marzaioli, S. Mastroianni, S. Mazzou, K. W. Melis, G. Miele, P. Migliozzi, E. Migneco, P. Mijakowski, L. S. Miranda, C. M. Mollo, M. Morganti, M. Moser, A. Moussa, R. Muller, M. Musumeci, L. Nauta, S. Navas, C. A. Nicolau, B. Ó Fearraigh, M. O’Sullivan, M. Organokov, A. Orlando, J. Palacios González, G. Papalashvili, R. Papaleo, G. Passaro, C. Pastore, A. M. Păun, G. E. Păvălaş, C. Pellegrino, M. Perrin-Terrin, V. Pestel, P. Piattelli, C. Pieterse, K. Pikounis, O. Pisanti, C. Poirè, V. Popa, T. Pradier, G. Pühlhofer, S. Pulvirenti, O. Rabyang, F. Raffaelli, N. Randazzo, S. Razzaque, D. Real, S. Reck, G. Riccobene, S. Rivoire, A. Romanov, A. Rovelli, F. Salesa Greus, D. F. E. Samtleben, A. Sánchez Losa, M. Sanguineti, A. Santangelo, D. Santonocito, P. Sapienza, J. Schnabel, M. F. Schneider, J. Schumann, H. M. Schutte, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, F. Simeone, A. Sinopoulou, B. Spisso, M. Spurio, D. Stavropoulos, S. M. Stellacci, M. Taiuti, Y. Tayalati, E. Tenllado, T. Thakore, H. Thiersen, S. Tingay, V. Tsourapis, E. Tzamariudaki, D. Tzanetatos, T. Unbehaun, V. Van Elewyck, G. Vannoye, G. Vasileiadis, F. Versari, S. Viola, D. Vivolo, G. de Wasseige, J. Wilms, R. Wojaczyński, E. de Wolf, S. Zavatarelli, A. Zegarelli, D. Zito, J. D. Zornoza, J. Zúñiga, and N. Zywucka

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The KM3NeT research infrastructure is under construction in the Mediterranean Sea. It consists of two water Cherenkov neutrino detectors, ARCA and ORCA, aimed at neutrino astrophysics and oscillation research, respectively. Instrumenting a large volume of sea water with $$\sim {6200}$$ ∼ 6200 optical modules comprising a total of $$\sim {200{,}000}$$ ∼ 200 , 000 photomultiplier tubes, KM3NeT will achieve sensitivity to $$\sim {10} \ \mathrm{MeV}$$ ∼ 10 MeV neutrinos from Galactic and near-Galactic core-collapse supernovae through the observation of coincident hits in photomultipliers above the background. In this paper, the sensitivity of KM3NeT to a supernova explosion is estimated from detailed analyses of background data from the first KM3NeT detection units and simulations of the neutrino signal. The KM3NeT observational horizon (for a $$5\,\sigma $$ 5 σ discovery) covers essentially the Milky-Way and for the most optimistic model, extends to the Small Magellanic Cloud ( $$\sim {60} \ \mathrm{kpc}$$ ∼ 60 kpc ). Detailed studies of the time profile of the neutrino signal allow assessment of the KM3NeT capability to determine the arrival time of the neutrino burst with a few milliseconds precision for sources up to 5–8 kpc away, and detecting the peculiar signature of the standing accretion shock instability if the core-collapse supernova explosion happens closer than 3–5 kpc, depending on the progenitor mass. KM3NeT’s capability to measure the neutrino flux spectral parameters is also presented.

Published
2021
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176. Long-term prognostic value of stress perfusion cardiovascular magnetic resonance in patients without known coronary artery disease

Author

Théo Pezel, Thierry Unterseeh, Marine Kinnel, Thomas Hovasse, Francesca Sanguineti, Solenn Toupin, Stéphane Champagne, Philippe Garot, and Jérôme Garot

Subjects
Cardiovascular magnetic resonance, Stress testing, Ischemia, Unrecognized myocardial infarction, Perfusion, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background To assess the incremental long-term prognostic value of vasodilator stress perfusion cardiovascular magnetic resonance (CMR) in patients without known coronary artery disease (CAD). Methods Between 2010 and 2011, consecutive patients with cardiovascular risk factors without known CAD referred for stress CMR were followed for the occurrence of major adverse cardiac events (MACE), defined by cardiovascular mortality or recurrent non-fatal myocardial infarction (MI). Uni- and multivariable Cox regressions were performed to determine the prognostic value of ischemia and unrecognized MI defined by sub-endocardial or transmural late gadolinium enhancement (LGE). Results Among 2,295 patients without known CAD, 2058 (89.7%) (71.2 ± 12.5 years; 37.5% males) completed the follow-up (median [IQR]: 8.3 [7.3–8.7] years), and 203 had MACE (9.9%). Using Kaplan–Meier analysis, ischemia and unrecognized MI were associated with MACE (hazard ratio, HR: 4.64 95% CI: 3.69–6.17 and HR: 2.88; 95% CI: 2.08–3.99, respectively; both p

Published
2021
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177. Validation of a biomarker tool capable of measuring the absorbed dose soon after exposure to ionizing radiation

Author

Anna Giovanetti, Raffaella Marconi, Noha Awad, Hala Abuzied, Neveen Agamy, Mohamed Barakat, Cecilia Bartoleschi, Gianluca Bossi, Marco Canfora, Amr A. Elsaid, Laura Ioannilli, Horeya M. Ismail, Yasmine Amr Issa, Flavia Novelli, Maria Chiara Pardini, Claudio Pioli, Paola Pinnarò, Giuseppe Sanguineti, Mohamed M. Tahoun, Riccardo Turchi, and Lidia Strigari

Subjects
Medicine, Science
Abstract

Abstract A radiological or nuclear attack could involve such a large number of subjects as to overwhelm the emergency facilities in charge. Resources should therefore be focused on those subjects needing immediate medical attention and care. In such a scenario, for the triage management by first responders, it is necessary to count on efficient biological dosimetry tools capable of early detection of the absorbed dose. At present the validated assays for measuring the absorbed dose are dicentric chromosomes and micronuclei counts, which require more than 2–3 days to obtain results. To overcome this limitation the NATO SPS Programme funded an Italian–Egyptian collaborative project aimed at validating a fast, accurate and feasible tool for assessing the absorbed dose early after radiation exposure. Biomarkers as complete blood cell counts, DNA breaks and radio-inducible proteins were investigated on blood samples collected before and 3 h after the first fraction of radiotherapy in patients treated in specific target areas with doses/fraction of about: 2, 3.5 or > 5 Gy and compared with the reference micronuclei count. Based on univariate and multivariate multiple linear regression correlation, our results identify five early biomarkers potentially useful for detecting the extent of the absorbed dose 3 h after the exposure.

Published
2021
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178. Prognostic value of stress cardiovascular magnetic resonance in asymptomatic patients with known coronary artery disease

Author

Théo Pezel, Thomas Hovasse, Marine Kinnel, Thierry Unterseeh, Stéphane Champagne, Solenn Toupin, Philippe Garot, Francesca Sanguineti, and Jérôme Garot

Subjects
Cardiovascular magnetic resonance, Stress testing, Ischemia, Asymptomatic, Coronary artery disease, Secondary prevention, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background Several studies have established the prognostic value of vasodilator stress cardiovascular magnetic resonance (CMR) in broad population of patients with suspected or known coronary artery disease (CAD), but this specific population of asymptomatic patients with known CAD have never been formally evaluated. To assess the long-term prognostic value of vasodilator stress perfusion CMR in asymptomatic patients with obstructive CAD. Methods Between 2009 and 2011, consecutive asymptomatic patients with obstructive CAD referred for vasodilator stress CMR were followed for the occurrence of major adverse cardiovascular events (MACE), defined by cardiovascular mortality or recurrent non-fatal myocardial infarction (MI). Uni- and multivariable Cox regressions were performed to determine the prognostic value of myocardial ischemia and myocardial infarction defined by late gadolinium enhancement (LGE) with ischemic pattern. Results Among 1529 asymptomatic patients with obstructive CAD, 1342 (87.8%; 67.7 ± 10.5 years, 82.0% males) completed the follow-up (median 8.3 years), and 195 had MACE (14.5%). Patients without stress-induced myocardial ischemia had a low annualized rate of MACE (2.4%), whereas the annualized rate of MACE was higher for patients with mild, moderate, or severe ischemia (7.3%, 16.8%, and 42.2%, respectively; ptrend

Published
2021
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179. Measurement of the atmospheric muon depth intensity relation with the NEMO Phase-2 tower

Author

Aiello, S., Ameli, F., Anghinolfi, M., Barbarino, G., Barbarito, E., Barbato, F., Beverini, N., Biagi, S., Bouhadef, B., Bozza, C., Cacopardo, G., Calamai, M., Calì, C., Capone, A., Caruso, F., Ceres, A., Chiarusi, T., Circella, M., Cocimano, R., Coniglione, R., Costa, M., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Luca, V., Deniskina, N., De Rosa, G., Di Capua, F., Distefano, C., Fermani, P., Fusco, L. A., Garufi, F., Giordano, V., Gmerk, A., Grasso, R., Grella, G., Hugon, C., Imbesi, M., Kulikovskiy, V., Larosa, G., Lattuada, D., Leismueller, K. P., Leonora, E., Litrico, P., Lonardo, A., Longhitano, F., Presti, D. Lo, Maccioni, E., Margiotta, A., Martini, A., Masullo, R., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C. M., Mongelli, M., Morganti, M., Musico, P., Musumeci, M., Nicolau, C. A., Orlando, A., Papaleo, R., Pellegrino, C., Pellegriti, M. G., Perrina, C., Piattelli, P., Pugliatti, C., Pulvirenti, S., Orselli, A., Raffaelli, F., Randazzo, N., Riccobene, G., Rovelli, A., Sanguineti, M., Sapienza, P., Sciacca, V., Sgura, I., Simeone, F., Sipala, V., Speziale, F., Spina, M., Spitaleri, A., Spurio, M., Stellacci, S. M., Taiuti, M., Terreni, G., Trasatti, L., Trovato, A., Ventura, C., Vicini, P., Viola, S., and Vivolo, D.

Subjects
Physics - Instrumentation and Detectors, Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

The results of the analysis of the data collected with the NEMO Phase-2 tower, deployed at 3500 m depth about 80 km off-shore Capo Passero (Italy), are presented. Cherenkov photons detected with the photomultipliers tubes were used to reconstruct the tracks of atmospheric muons. Their zenith-angle distribution was measured and the results compared with Monte Carlo simulations. An evaluation of the systematic effects due to uncertainties on environmental and detector parameters is also included. The associated depth intensity relation was evaluated and compared with previous measurements and theoretical predictions. With the present analysis, the muon depth intensity relation has been measured up to 13 km of water equivalent., Comment: submitted to Astroparticle Physics

Published
2014
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180. Implementation and first results of the KM3NeT real-time core-collapse supernova neutrino search

Author

Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Baret, B., Pree, S. Basegmez du, Bendahman, M., Benfenati, F., Berbee, E., Berg, A. M. van den, Bertin, V., Biagi, S., Boettcher, M., Cabo, M. Bou, Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Molla, M. Colomer, Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., De Martino, B., Palma, I. Di, Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., Eeden, T. van, Eijk, D. van, Bojaddaini, I. El, Hedri, S. El, Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gal, T., Méndez, J. García, Soto, A. Garcia, Garufi, F., Gatelet, Y., Oliver, C. Gatius, Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., Haren, H. van, Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Ibnsalih, W. Idrissi, Illuminati, G., James, C. W., Janezashvili, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Chowdhury, N. R. Khan, Kistauri, G., Knaap, F. van der, Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Breton, R. Le, Stum, S. Le, Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Clark, M. Lindsey, Lipreau, T., Alvarez, C. LLorens, Longhitano, F., Lopez-Coto, D., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O’Sullivan, M., Organokov, M., Orlando, A., González, J. Palacios, Papalashvili, G., Papaleo, R., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quéméner, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Romanov, A., Rovelli, A., Greus, F. Salesa, Samtleben, D. F. E., Losa, A. Sánchez, Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tayalati, Y., Thiersen, H., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Elewyck, V. Van, Vannoye, G., Vasileiadis, G., Versari, F., Viola, S., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Published
2022
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181. Combined sensitivity of JUNO and KM3NeT/ORCA to the neutrino mass ordering

Author

Aiello, S., Albert, A., Alshamsi, M., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Baret, B., Basegmez du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., van den Berg, A. M., Bertin, V., Biagi, S., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Campion, S., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer-Molla, M., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., De Martino, B., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., van Eijk, D., El Bojaddaini, I., Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gal, T., García Méndez, J., Garcia Soto, A., Garufi, F., Gatelet, Y., Gatius, C., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grella, G., Guderian, D., Guidi, C., Guillon, B., Gutiérrez, M., Haefner, J., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Idrissi Ibnsalih, W., Illuminati, G., James, C. W., Janezashvili, D., de Jong, M., de Jong, P., Jung, B. J., Kalaczyński, P., Kalekin, O., Katz, U. F., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kulikovskiy, V., Labalme, M., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Lazo, A., Le Breton, R., Le Stum, S., Lehaut, G., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., LLorens Alvarez, C., Longhitano, F., Lopez-Coto, D., Lygda, A., Maderer, L., Majumdar, J., Mańczak, J., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Nkosi, B., Fearraigh, B. Ó, O’Sullivan, M., Organokov, M., Orlando, A., Palacios González, J., Papalashvili, G., Papaleo, R., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Probst, I., Pulvirenti, S., Quéméner, G., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Romanov, A., Rovelli, A., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santonocito, D., Sapienza, P., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tayalati, Y., Thiersen, H., Tingay, S., Tsagkli, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vasileiadis, G., Versari, F., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., Zywucka, N., Ahmad, S., de André, J. P. A. M., Baussan, E., Bordereau, C., Cabrera, A., Cerna, C., Donchenko, G., Doroshkevich, E. A., Dracos, M., Druillole, F., Jollet, C., Kalousis, L. N., Kampmann, P., Kouzakov, K., Lokhov, A., Lubsandorzhiev, B. K., Lubsandorzhiev, S. B., Meregaglia, A., Miramonti, L., Perrot, F., Piñeres Rico, L. F., Popov, A., Rasheed, R., Settimo, M., Stankevich, K., Steiger, H., Stock, M. R., Studenikin, A., Triossi, A., Trzaska, W., Vialkov, M., Wonsak, B., Wurtz, J., and Yermia, F.

Published
2022
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183. Loss of HER2 and decreased T-DM1 efficacy in HER2 positive advanced breast cancer treated with dual HER2 blockade: the SePHER Study

Author

Giulia Bon, Laura Pizzuti, Valentina Laquintana, Rossella Loria, Manuela Porru, Caterina Marchiò, Eriseld Krasniqi, Maddalena Barba, Marcello Maugeri-Saccà, Teresa Gamucci, Rossana Berardi, Lorenzo Livi, Corrado Ficorella, Clara Natoli, Enrico Cortesi, Daniele Generali, Nicla La Verde, Alessandra Cassano, Emilio Bria, Luca Moscetti, Andrea Michelotti, Vincenzo Adamo, Claudio Zamagni, Giuseppe Tonini, Giacomo Barchiesi, Marco Mazzotta, Daniele Marinelli, Silverio Tomao, Paolo Marchetti, Maria Rosaria Valerio, Rosanna Mirabelli, Antonio Russo, Maria Agnese Fabbri, Nicola D’Ostilio, Enzo Veltri, Domenico Corsi, Ornella Garrone, Ida Paris, Giuseppina Sarobba, Francesco Giotta, Carlo Garufi, Marina Cazzaniga, Pietro Del Medico, Mario Roselli, Giuseppe Sanguineti, Isabella Sperduti, Anna Sapino, Ruggero De Maria, Carlo Leonetti, Angelo Di Leo, Gennaro Ciliberto, Rita Falcioni, and Patrizia Vici

Subjects
HER2+ breast cancer, Trastuzumab/pertuzumab blockade, T-DM1 efficacy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background HER2-targeting agents have dramatically changed the therapeutic landscape of HER2+ advanced breast cancer (ABC). Within a short time frame, the rapid introduction of new therapeutics has led to the approval of pertuzumab combined with trastuzumab and a taxane in first-line, and trastuzumab emtansine (T-DM1) in second-line. Thereby, evidence of T-DM1 efficacy following trastuzumab/pertuzumab combination is limited, with data from some retrospective reports suggesting lower activity. The purpose of the present study is to investigate T-DM1 efficacy in pertuzumab-pretreated and pertuzumab naïve HER2 positive ABC patients. We also aimed to provide evidence on the exposure to different drugs sequences including pertuzumab and T-DM1 in HER2 positive cell lines. Methods The biology of HER2 was investigated in vitro through sequential exposure of resistant HER2 + breast cancer cell lines to trastuzumab, pertuzumab, and their combination. In vitro experiments were paralleled by the analysis of data from 555 HER2 + ABC patients treated with T-DM1 and evaluation of T-DM1 efficacy in the 371 patients who received it in second line. Survival estimates were graphically displayed in Kaplan Meier curves, compared by log rank test and, when possibile, confirmed in multivariate models. Results We herein show evidence of lower activity of T-DM1 in two HER2+ breast cancer cell lines resistant to trastuzumab+pertuzumab, as compared to trastuzumab-resistant cells. Lower T-DM1 efficacy was associated with a marked reduction of HER2 expression on the cell membrane and its nuclear translocation. HER2 downregulation at the membrane level was confirmed in biopsies of four trastuzumab/pertuzumab-pretreated patients. Among the 371 patients treated with second-line T-DM1, median overall survival (mOS) from diagnosis of advanced disease and median progression-free survival to second-line treatment (mPFS2) were 52 and 6 months in 177 patients who received trastuzumab/pertuzumab in first-line, and 74 and 10 months in 194 pertuzumab-naïve patients (p = 0.0006 and 0.03 for OS and PFS2, respectively). Conclusions Our data support the hypothesis that the addition of pertuzumab to trastuzumab reduces the amount of available plasma membrane HER2 receptor, limiting the binding of T-DM1 in cancer cells. This may help interpret the less favorable outcomes of second-line T-DM1 in trastuzumab/pertuzumab pre-treated patients compared to their pertuzumab-naïve counterpart.

Published
2020
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184. Clinical and Cardiovascular Magnetic Resonance Predictors of Early and Long-Term Clinical Outcome in Acute Myocarditis

Author

Yohann Bohbot, Jérôme Garot, Thomas Hovasse, Thierry Unterseeh, Chloé Di Lena, Wahiba Boukefoussa, Chloé Tawa, Cédric Renard, Isabelle Limouzineau, Suzanne Duhamel, Philippe Garot, Christophe Tribouilloy, and Francesca Sanguineti

Subjects
cardiovascular magnetic resonance, outcome, late gadolinium enhancement, left ventricular ejection fraction, myocarditis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

IntroductionThe natural history of acute myocarditis (AM) remains partially unknown and predictors of outcome are debated. We sought to assess the impact of various cardiac magnetic resonance (CMR) parameters on early and long-term prognosis in a population of patients with AM.Materials and MethodsIn a two-center longitudinal study, we included consecutive patients with diagnosis of AM based on CMR and without hemodynamic compromise. The primary endpoint was the occurrence of an event in the acute phase (≤15 days). Secondary endpoints were the occurrence of major adverse cardiac events (MACE) and recurrence of AM during follow-up.ResultsThree hundred and eighty-eight patients were included [mean age 38.5 years, 77.3% male, mean ejection fraction (EF):56%] of which 82% (317) presented with chest pain. CMR was performed 4 ± 2 days after index presentation. Overall, 38 patients (9.8%) had an event at the acute phase, 41 (10.6%) presented at least one MACE during follow-up (median 7.5 years, 6.6–8.9) and 30 (7.7%) experienced a recurrence of AM. By multivariate analysis, the independent predictors of initial complications were absence of chest pain (OR [95%CI] = 0.35 [0.15–0.82]), presence of syncope/pre-syncope (OR [95%CI] = 3.56 [1.26–10.02]), lower EF (OR [95%CI] = 0.94 [0.91–0.98] per%), myocardial extent of late gadolinium enhancement (LGE) (OR [95%CI] = 1.05 [1.002–1.100] per%) and absence of edema (OR [95%CI] = 0.44 [0.19–0.97]). Only age (HR [95%CI] = 1.021 [1.001–1.041] per year) and an initial alteration of EF (HR [95%CI] = 0.94 [0.91–0.97] per%) were associated with MACE during follow-up. Factors independently associated with AM recurrence were myocarditis prior to the index episodes (HR [95%CI] = 5.74 [1.72–19.22]) and viral syndrome at the index episode (HR [95%CI] = 4.21 [1.91–9.28]).ConclusionIn routine consecutive hemodynamically stable patients with diagnosis of AM based on CMR, absence of edema, reduced EF, and extent of LGE were associated with early adverse outcome. Only age and EF were associated with long-term events.

Published
2022
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185. High-energy neutrino follow-up search of gravitational wave event GW150914 with ANTARES and IceCube

Author

Adrián-Martínez, S, Albert, A, André, M, Anghinolfi, M, Anton, G, Ardid, M, Aubert, JJ, Avgitas, T, Baret, B, Barrios-Martí, J, Basa, S, Bertin, V, Biagi, S, Bormuth, R, Bouwhuis, MC, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Celli, S, Chiarusi, T, Circella, M, Coleiro, A, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Deschamps, A, De Bonis, G, Distefano, C, Donzaud, C, Dornic, D, Drouhin, D, Eberl, T, El Bojaddaini, I, Elsässer, D, Enzenhöfer, A, Fehn, K, Felis, I, Fusco, LA, Galatà, S, Gay, P, Geißelsöder, S, Geyer, K, Giordano, V, Gleixner, A, Glotin, H, Gracia-Ruiz, R, Graf, K, Hallmann, S, Van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hößl, J, Hofestädt, J, Hugon, C, Illuminati, G, James, CW, De Jong, M, Jongen, M, Kadler, M, Kalekin, O, Katz, U, Kießling, D, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lachaud, C, Lahmann, R, Lefèvre, D, Leonora, E, Loucatos, S, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Mathieu, A, Melis, K, Michael, T, Migliozzi, P, Moussa, A, Mueller, C, Nezri, E, PǍvǍlaş, GE, Pellegrino, C, Perrina, C, Piattelli, P, Popa, V, Pradier, T, Racca, C, Riccobene, G, Roensch, K, Saldaña, M, Samtleben, DFE, Sánchez-Losa, A, and Sanguineti, M

Subjects
astro-ph.HE
Abstract

We present the high-energy-neutrino follow-up observations of the first gravitational wave transient GW150914 observed by the Advanced LIGO detectors on September 14, 2015. We search for coincident neutrino candidates within the data recorded by the IceCube and Antares neutrino detectors. A possible joint detection could be used in targeted electromagnetic follow-up observations, given the significantly better angular resolution of neutrino events compared to gravitational waves. We find no neutrino candidates in both temporal and spatial coincidence with the gravitational wave event. Within ±500 s of the gravitational wave event, the number of neutrino candidates detected by IceCube and Antares were three and zero, respectively. This is consistent with the expected atmospheric background, and none of the neutrino candidates were directionally coincident with GW150914. We use this nondetection to constrain neutrino emission from the gravitational-wave event.

Published
2016

186. THE FIRST COMBINED SEARCH FOR NEUTRINO POINT-SOURCES IN THE SOUTHERN HEMISPHERE WITH THE ANTARES AND ICECUBE NEUTRINO TELESCOPES

Author

Adrián-Martínez, S, Albert, A, André, M, Anton, G, Ardid, M, Aubert, J-J, Baret, B, Barrios-Martí, J, Basa, S, Bertin, V, Biagi, S, Bormuth, R, Bouwhuis, MC, Bruijn, R, Brunner, J, Busto, J, Capone, A, Caramete, L, Carr, J, Chiarusi, T, Circella, M, Coniglione, R, Costantini, H, Coyle, P, Creusot, A, Dekeyser, I, Deschamps, A, De Bonis, G, Distefano, C, Donzaud, C, Dornic, D, Drouhin, D, Dumas, A, Eberl, T, Elsässer, D, Enzenhöfer, A, Fehn, K, Felis, I, Fermani, P, Folger, F, Fusco, LA, Galatà, S, Gay, P, Geißelsöder, S, Geyer, K, Giordano, V, Gleixner, A, Gracia-Ruiz, R, Graf, K, Hallmann, S, van Haren, H, Heijboer, AJ, Hello, Y, Hernández-Rey, JJ, Hößl, J, Hofestädt, J, Hugon, C, James, CW, de Jong, M, Kadler, M, Kalekin, O, Katz, U, Kießling, D, Kooijman, P, Kouchner, A, Kreter, M, Kreykenbohm, I, Kulikovskiy, V, Lahmann, R, Lefèvre, D, Leonora, E, Loucatos, S, Marcelin, M, Margiotta, A, Marinelli, A, Martínez-Mora, JA, Mathieu, A, Michael, T, Migliozzi, P, Moussa, A, Mueller, C, Nezri, E, Păvălaş, GE, Pellegrino, C, Perrina, C, Piattelli, P, Popa, V, Pradier, T, Racca, C, Riccobene, G, Richter, R, Roensch, K, Saldaña, M, Samtleben, DFE, Sánchez-Losa, A, Sanguineti, M, Sapienza, P, Schmid, J, Schnabel, J, and Schüssler, F

Subjects
astroparticle physics, neutrinos, hep-ex, astro-ph.HE, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Physical Chemistry (incl. Structural), Astronomy & Astrophysics
Abstract

We present the results of searches for point-like sources of neutrinos based on the first combined analysis of data from both the ANTARES and IceCube neutrino telescopes. The combination of both detectors, which differ in size and location, forms a window in the southern sky where the sensitivity to point sources improves by up to a factor of 2 compared with individual analyses. Using data recorded by ANTARES from 2007 to 2012, and by IceCube from 2008 to 2011, we search for sources of neutrino emission both across the southern sky and from a preselected list of candidate objects. No significant excess over background has been found in these searches, and flux upper limits for the candidate sources are presented for E -2.5 and E -2 power-law spectra with different energy cut-offs.

Published
2016

187. Constraining the neutrino emission of gravitationally lensed Flat-Spectrum Radio Quasars with ANTARES data

Author

Adrián-Martínez, S., Albert, A., André, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios-Martì, J., Basa, S., Bertin, V., Biagi, S., Bogazzi, C., Bormuth, R., Bou-Cabo, M., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Chiarusi, T., Circella, M., Coniglione, R., Core, L., Costantini, H., Coyle, P., Creusot, A., De Rosa, G., Dekeyser, I., Deschamps, A., DeBonis, G., Distefano, C., Donzaud, C., Dornic, D., Dorosti, Q., Drouhin, D., Dumas, A., Eberl, T., Elsässer, D., Enzenhöfer, A., Escoffier, S., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gómez-González, J. P., Graf, K., Guillard, G., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Herold, B., Herrero, A., Hößl, J., Hofestädt, J., Hugon, C., James, C. W., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lambard, E., Lambard, G., Lefèvre, D., Leonora, E., Loehner, H., Loucatos, S., Mangano, S., Marcelin, M., Margiotta, A., Martínez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Müller, C., Neff, M., Nezri, E., Palioselitis, D., Păvălaş, G. E., Perrina, C., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Rostovtsev, A., Saldaña, M., Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Schmid, J., Schnabel, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spies, A., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Taiuti, M., Tamburini, C., Tayalati, Y., Trovato, A., Tselengidou, M., Tönnis, C., Vallage, B., Vallée, C., Van Elewyck, V., Visser, E., Vivolo, D., Wagner, S., Wilms, J., de Wolf, E., Yatkin, K., Yepes, H., Zornoza, J. D., Zúñiga, J., and Falco, E. E.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

This paper proposes to exploit gravitational lensing effects to improve the sensitivity of neutrino telescopes to the intrinsic neutrino emission of distant blazar populations. This strategy is illustrated with a search for cosmic neutrinos in the direction of four distant and gravitationally lensed Flat-Spectrum Radio Quasars. The magnification factor is estimated for each system assuming a singular isothermal profile for the lens. Based on data collected from 2007 to 2012 by the ANTARES neutrino telescope, the strongest constraint is obtained from the lensed quasar B0218+357, providing a limit on the total neutrino luminosity of this source of $1.08\times 10^{46}\,\mathrm{erg}\,\mathrm{s}^{-1}$. This limit is about one order of magnitude lower than those previously obtained in the ANTARES standard point source searches with non-lensed Flat-Spectrum Radio Quasars., Comment: 12 pages, 1 figure, 1 table; abstract shortened and references added

Published
2014
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188. Deep sea tests of a prototype of the KM3NeT digital optical module

Author

Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., Anassontzis, E. G., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., de Asmundis, R., Balasi, K., Band, H., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., Baron, S., Belias, A., Berbee, E., Berg, A. M. van den, Berkien, A., Bertin, V., Beurthey, S., van Beveren, V., Beverini, N., Biagi, S., Bianucci, S., Billault, M., Birbas, A., Rookhuizen, H. Boer, Bormuth, R., Bouche, V., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bozza, C., Bruijn, R., Brunner, J., Cacopardo, G., Caillat, L., Calamai, M., Calvo, D., Capone, A., Caramete, L., Caruso, F., Cecchini, S., Ceres, A., Cereseto, R., Champion, C., Chateau, F., Chiarusi, T., Christopoulou, B., Circella, M., Classen, L., Cocimano, R., Colonges, S., Coniglione, R., Cosquer, A., Costa, M., Coyle, P., Creusot, A., Curtil, C., Cuttone, G., D'Amato, C., D'Amico, A., De Bonis, G., De Rosa, G., Deniskina, N., Destelle, J. -J., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drakopoulou7, E., Drouhin, D., Drury, L., Durand, D., Eberl, T., Eleftheriadis, C., Elsaesser, D., Enzenhofer, A., Fermani, P., Fusco, L. A., Gajana, D., Gal, T., Galata, S., Gallo, F., Garufi, F., Gebyehu, M., Giordano, V., Gizani, N., Ruiz, R. Gracia, Graf, K., Grasso, R., Grella, G., Grmek, A., Habel, R., van Haren, H., Heid, T., Heijboer, A., Heine, E., Henry, S., Hernandez-Rey, J. J., Herold, B., Hevinga, M. A., van der Hoek, M., Hofestadt, J., Hogenbirk, J., Hugon, C., Hosl, J., Imbesi, M., James, C., Jansweijer, P., Jochum, J., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Kappos, E., Katz, U., Kavatsyuk, O., Keller, P., Kieft, G., Koffeman, E., Kok, H., Kooijman, P., Koopstra, J., Korporaal, A., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Provost, H. Le, Leisos, A., Lenis, D., Leonora, E., Clark, M. Lindsey, Liolios, A., Alvarez, C. D. Llorens, Lohner, H., Presti, D. Lo, Louis, F., Maccioni, E., Mannheim, K., Manolopoulos, K., Margiotta, A., Maris, O., Markou, C., Martinez-Mora, J. A., Martini, A., Masullo, R., Michael, T., Migliozzi, P., Migneco, E., Miraglia, A., Mollo, C., Mongelli, M., Morganti, M., Mos, S., Moudden, Y., Musico, P., Musumeci, M., Nicolaou, C., Nicolau, C. A., Orlando, A., Orzelli, A., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Peek, H., Pellegrino, C., Pellegriti, M. G., Perrina, C., Petridou, C., Piattelli, P., Pikounis, K., Popa, V., Pradier, Th., Priede, M., Puhlhofer, G., Pulvirenti, S., Racca, C., Raffaelli, F., Randazzo, N., Rapidis, P. A., Razis, P., Real, D., Resvanis, L., Reubelt, J., Riccobene, G., Rovelli, A., Royon, J., Saldana, M., Samtleben, D. F. E., Sanguineti, M., Santangelo, A., Sapienza, P., Savvidis, I., Schmelling, J., Schnabel, J., Sedita, M., Seitz, T., Sgura, I., Simeone, F., Siotis, I., Sipala, V., Solazzo, M., Spitaleri, A., Spurio, M., Stavropoulos, G., Steijger, J., Stolarczyk, T., Stransky, D., Taiuti, M., Terreni, G., Tezier, D., Theraube, S., Thompson, L. F., Timmer, P., Trapierakis, H. I., Trasatti, L., Trovato, A., Tselengidou, M., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Vallage, B., Van Elewyck, V., Vermeulen, J., Vernin, P., Viola, S., Vivolo, D., Werneke, P., Wiggers, L., Wilms, J., de Wolf, E., van Wooning, R. H. L., Yatkin, K., Zachariadou, K., Zonca, E., Zornoza, J. D., Zúñiga, J., and Zwart, A.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Instrumentation and Detectors
Abstract

The first prototype of a photo-detection unit of the future KM3NeT neutrino telescope has been deployed in the deep waters of the Mediterranean Sea. This digital optical module has a novel design with a very large photocathode area segmented by the use of 31 three inch photomultiplier tubes. It has been integrated in the ANTARES detector for in-situ testing and validation. This paper reports on the first months of data taking and rate measurements. The analysis results highlight the capabilities of the new module design in terms of background suppression and signal recognition. The directionality of the optical module enables the recognition of multiple Cherenkov photons from the same $^{40}$K decay and the localization bioluminescent activity in the neighbourhood. The single unit can cleanly identify atmospheric muons and provide sensitivity to the muon arrival directions.

Published
2014
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189. Searches for Point-like and extended neutrino sources close to the Galactic Centre using the ANTARES neutrino Telescope

Author

ANTARES Collaboration, Adrián-Martínez, S., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios-Martí, J., Basa, S., Bertin, V., Biagi, S., Bogazzi, C., Bormuth, R., Bou-Cabo, M., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Cârloganu, C., Carr, J., Chiarusi, T., Circella, M., Core, L., Costantini, H., Coyle, P., Creusot, A., Curtil, C., De Rosa, G., Dekeyser, I., Deschamps, A., De Bonis, G., Distefano, C., Donzaud, C., Dornic, D., Dorosti, Q., Drouhin, D., Dumas, A., Eberl, T., Elsässer, D., Enzenhöfer, A., Escoffier, S., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gómez-González, J. P., Graf, K., Guillard, G., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Herold, B., Herrero, A., Hößl, J., Hofestädt, J., James, C. W, de Jong, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lambard, E., Lambard, G., Lattuada, D., Lefèvre, D., Leonora, E., Loehner, H., Loucatos, S., Mangano, S., Marcelin, M., Margiotta, A., Martínez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Mueller, C., Neff, M., Nezri, E., Palioselitis, D., Păvălaş, G. E., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Rostovtsev, A., Saldaña, M., Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Sapienza, P., Schmid, J., Schnabe, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spies, A., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Taiuti, M., Tamburini, C., Tayalati, Y., Trovato, A., Vallage, B., Vallée, C., Van Elewyck, V., Visser, E., Vivolo, D., Wagner, S., Wilms, J., de Wolf, E., Yatkin, K., Yepes, H., Zornoza, J. D., and Zúñiga, J.

Subjects
High Energy Physics - Experiment, Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

A search for cosmic neutrino sources using six years of data collected by the ANTARES neutrino telescope has been performed. Clusters of muon neutrinos over the expected atmospheric background have been looked for. No clear signal has been found. The most signal-like accumulation of events is located at equatorial coordinates RA=$-$46.8$^{\circ}$ and Dec=$-$64.9$^{\circ}$ and corresponds to a 2.2$\sigma$ background fluctuation. In addition, upper limits on the flux normalization of an E$^{-2}$ muon neutrino energy spectrum have been set for 50 pre-selected astrophysical objects. Finally, motivated by an accumulation of 7 events relatively close to the Galactic Centre in the recently reported neutrino sample of the IceCube telescope, a search for point sources in a broad region around this accumulation has been carried out. No indication of a neutrino signal has been found in the ANTARES data and upper limits on the flux normalization of an E$^{-2}$ energy spectrum of neutrinos from point sources in that region have been set. The 90% confidence level upper limits on the muon neutrino flux normalization vary between 3.5 and 5.1$\times$10$^{-8}$ GeV$\,$cm$^{-2}$s$^{-1}$, depending on the exact location of the source., Comment: Submitted to ApJL. 18 pages, 4 figures

Published
2014
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190. Searches for clustering in the time integrated skymap of the ANTARES neutrino telescope

Author

Adrián-Martínez, S., Albert, A., André, M., Anton, G., Ardid, M., Aubert, J. -J., Baret, B., Barrios-Martí, J., Basa, S., Bertin, V., Biagi, S., Bogazzi, C., Bormuth, R., Bou-Cabo, M., Bouwhuis, M. C., Bruijn, R., Brunner, J., Busto, J., Capone, A., Caramete, L., Carr, J., Cecchini, S., Chiarusi, T., Circella, M., Coniglione, R., Core, L., Costantini, H., Coyle, P., Creusot, A., Curtil, C., De Rosa, G., Dekeyser, I., Deschamps, A., De Bonis, G., Donzaud, C., Dornic, D., Dorosti, Q., Drouhin, D., Dumas, A., Eberl, T., Elsässer, D., Enzenhöfer, A., Escoffier, S., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gómez-González, J. P., Graf, K., Guillard, G., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Herold, B., Herrero, A., Hößl, J., Hofestädt, J., Hugon, C., James, C. W, de Jong, M., Kadler, M., Kalekin, O., Katz, U., Kießling, D., Kooijman, P., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lambard, E., Lambard, G., Lattuada, D., Lefèvre, D., Leonora, E., Loehner, H., Loucatos, S., Mangano, S., Marcelin, M., Margiotta, A., Martínez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Mueller, C., Neff, M., Nezri, E., Palioselitis, D., Pavalas, G. E., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Roensch, K., Rostovtsev, A., Saldaña, M., Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Schmid, J., Schnabel, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spies, A., Spurio, M., Steijger, J. J. M., Stolarczyk, Th., Taiuti, M., Tamburini, C., Tayalati, Y., Trovato, A., Vallage, B., Vallée, C., Van Elewyck, V., Visser, E., Vivolo, D., Wagner, S., Wilms, J., de Wolf, E., Yatkin, K., Yepes, H., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

This paper reports a search for spatial clustering of the arrival directions of high energy muon neutrinos detected by the ANTARES neutrino telescope. An improved two-point correlation method is used to study the autocorrelation of 3058 neutrino candidate events as well as cross-correlations with other classes of astrophysical objects: sources of high energy gamma rays, massive black holes and nearby galaxies. No significant deviations from the isotropic distribution of arrival directions expected from atmospheric backgrounds are observed., Comment: published version

Published
2014
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191. A Search for Time Dependent Neutrino Emission from Microquasars with the ANTARES Telescope

Author

Adrián-Martínez, S., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Astraatmadja, T., Aubert, J. -J., Baret, B., Barrios, J., Basa, S., Bertin, V., Biagi, S., Bigongiari, C., Bogazzi, C., Bouhou, B., Bouwhuis, M. C., Brunner, J., Busto, J., Capone, A., Caramete, L., Cârloganu, C., Carr, J., Cecchini, S., Charif, Z., Charvis, P., Chiarusi, T., Circella, M., Coniglione, R., Core, L., Costantini, H., Coyle, P., Creusot, A., De Rosa, G., Dekeyser, I., Deschamps, A., De Bonis, G., Distefano, C., Donzaud, C., Dornic, D., Dorosti, Q., Drouhin, D., Dumas, A., Eberl, T., Elsässer, D., Emanuele, U., Enzenhöfer, A., Ernenwein, J. -P., Escoffier, S., Fehn, K., Felis, I., Fermani, P., Folger, F., Fusco, L. A., Galatà, S., Gay, P., Geißelsöder, S., Geyer, K., Giordano, V., Gleixner, A., Gómez-González, J. P., Graf, K., Guillard, G., van Haren, H., Heijboer, A. J., Hello, Y., Hernández-Rey, J. J., Herold, B., Hößl, J., Hofestädt, J., James, C. W., de Jong, M., Kadler, M., Kalekin, O., Kappes, A., Katz, U., Kooijman, P., Kouchner, A., Kreykenbohm, I., Kulikovskiy, V., Lahmann, R., Lambard, E., Lambard, G., Larosa, G., Lattuada, D., Lefèvre, D., Leonora, E., Loehner, H., Loucatos, S., Mangano, S., Marcelin, M., Margiotta, A., Martínez-Mora, J. A., Martini, S., Mathieu, A., Michael, T., Migliozzi, P., Montaruli, T., Müller, C., Neff, M., Nezri, E., Palioselitis, D., Păvălaş, G. E., Perrina, C., Piattelli, P., Popa, V., Pradier, T., Racca, C., Riccobene, G., Richter, R., Rivière, C., Robert, A., Roensch, K., Rostovtsev, A., Saldaña, M., Samtleben, D. F. E., Sánchez-Losa, A., Sanguineti, M., Sapienza, P., Schmid, J., Schnabel, J., Schulte, S., Schüssler, F., Seitz, T., Sieger, C., Spies, A., Spurio, M., Steijger, J. J. M., Stolarczyk, T., Taiuti, M., Tamburini, C., Tayalati, Y., Trovato, A., Vallage, B., Vallée, C., Van Elewyck, V., Vernin, P., Visser, E., Vivolo, D., Wagner, S., Wilms, J., de Wolf, E., Yatkin, K., Yepes, H., Zornoza, J. D., and Zúñiga, J.

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Results are presented on a search for neutrino emission from a sample of six microquasars, based on the data collected by the ANTARES neutrino telescope between 2007 and 2010. By means of appropriate time cuts, the neutrino search has been restricted to the periods when the acceleration of relativistic jets was taking place at the microquasars under study. The time cuts have been chosen using the information from the X-ray telescopes RXTE/ASM and Swift/BAT, and, in one case, the gamma-ray telescope Fermi/LAT. Since none of the searches has produced a statistically significant signal, upper limits on the neutrino fluences are derived and compared to the predictions from theoretical models.

Published
2014

192. TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients

Author

Andrea Sacconi, Sara Donzelli, Claudio Pulito, Stefano Ferrero, Francesca Spinella, Aldo Morrone, Marta Rigoni, Fulvia Pimpinelli, Fabrizio Ensoli, Giuseppe Sanguineti, Raul Pellini, Nishant Agrawal, Evgeny Izumchenko, Gennaro Ciliberto, Aldo Giannì, Paola Muti, Sabrina Strano, and Giovanni Blandino

Subjects
SARS-CoV-2, TMPRSS2, HNSCC, microRNAs TP53, MYC, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background SARS-coronavirus-2 enters host cells through binding of the Spike protein to ACE2 receptor and subsequent S priming by the TMPRSS2 protease. We aim to assess differences in both ACE2 and TMPRSS2 expression in normal tissues from oral cavity, pharynx, larynx and lung tissues as well as neoplastic tissues from the same areas. Methods The study has been conducted using the TCGA and the Regina Elena Institute databases and validated by experimental model in HNSCC cells. We also included data from one COVID19 patient who went under surgery for HNSCC. Results TMPRSS2 expression in HNSCC was significantly reduced compared to the normal tissues. It was more evident in women than in men, in TP53 mutated versus wild TP53 tumors, in HPV negative patients compared to HPV positive counterparts. Functionally, we modeled the multivariate effect of TP53, HPV, and other inherent variables on TMPRSS2. All variables had a statistically significant independent effect on TMPRSS2. In particular, in tumor tissues, HPV negative, TP53 mutated status and elevated TP53-dependent Myc-target genes were associated with low TMPRSS2 expression. The further analysis of both TCGA and our institutional HNSCC datasets identified a signature anti-correlated to TMPRSS2. As proof-of-principle we also validated the anti-correlation between microRNAs and TMPRSS2 expression in a SARS-CoV-2 positive HNSCC patient tissues Finally, we did not find TMPRSS2 promoter methylation. Conclusions Collectively, these findings suggest that tumoral tissues, herein exemplified by HNSCC and lung cancers might be more resistant to SARS-CoV-2 infection due to reduced expression of TMPRSS2. These observations may help to better assess the frailty of SARS-CoV-2 positive cancer patients.

Published
2020
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193. Breast cancer surgery during the Covid-19 pandemic: a monocentre experience from the Regina Elena National Cancer Institute of Rome

Author

Fabio Pelle, Sonia Cappelli, Franco Graziano, Loredana Piarulli, Flavia Cavicchi, Domenico Magagnano, Assunta De Luca, Roy De Vita, Marcello Pozzi, Maurizio Costantini, Antonio Varanese, Massimo Panimolle, Pietro Paolo Gullo, Maddalena Barba, Patrizia Vici, Enrico Vizza, Francesco Cognetti, Giuseppe Sanguineti, Elena Saracca, Gennaro Ciliberto, and Claudio Botti

Subjects
Covid-19 pandemic, elective breast cancer surgery, safety, Covid-19 protective cancer hubs, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract The Covid-19 pandemic has challenged hard the national health systems worldwide. According to the national policy issued in March 2020 in response to the evolving Covid-19 pandemic, several hospitals were re-configured as Covid-19 centers and elective surgery procedures were rescheduled according to the most recent recommendations. In addition, Covid-19 protected cancer hubs were established, including the Regina Elena National Cancer Institute of Rome, Central Italy. At our Institute, the Breast Surgery Department continued working under the sign of a multidisciplinary approach. The number of professional figures involved in case evaluation was reduced to a minimum and interactions took place in the full respect of the required safety measures. Treatments for benign disease, pure prophylactic surgery and elective reconstructive procedures were all postponed and priority was assigned to the histologically-proven malignant breast tumors and highly suspicious lesions. From March 15th though April 30th 2020, we treated a total of 79 patients. This number is fully consistent with the average quantitative standards reached by our Department under ordinary circumstances. Patients were mostly discharged the day after surgery and none was readmitted due to surgery-related late complications. More generally, post-operative complications rates were unexpectedly low, particularly in light of the relatively high number of reconstructive procedures performed in this emergency situation. A strict follow up was performed based on the close contact with the surgical staff by telephone, messaging apps and telemedicine. Patients ascertainment for their Covid-19 status prior to hospital admission and hospital discharge allowed to maintain the “no-Covid-19” status at our Institution. In addition, during the aforementioned time window, none of the care providers developed SARS-CoV-2 infection or disease, as shown by the results of anti-SARS-CoV-2 immunoglobulin M and G profiling. In conclusions, elective breast cancer surgery procedures were successfully performed in a lockdown situation due to a novel viral pandemic. The well-coordinated regional and hospital efforts in terms of medical resource re-allocation and definition of clinical priorities allowed to maintain high quality standards of breast cancer care while ensuring safety to the cancer patients and care providers involved.

Published
2020
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194. ¿Se puede comparar la filosofía de Tomás de Aquino con la ciencia moderna?

Author

Juan José Sanguineti

Subjects
creación, evolución, indeterminismo, providencia de dios, neurociencia, Doctrinal Theology, BT10-1480, Practical Theology, BV1-5099, Philosophy (General), B1-5802
Abstract

Una comparación entre la filosofía de Tomás de Aquino y la ciencia moderna es posible y puede ser fructífera. Algunos aspectos de su visión del mundo natural son incompatibles con nuestros conocimientos científicos, pero otros son del todo compatibles y relevantes para una correcta interpretación de los logros de las ciencias, teniendo en cuenta la distinción entre ciencia y filosofía, desconocida antes de la época moderna. El artículo explora brevemente esta temática en la cosmología, la teoría evolutiva (especialmente el problema de la contingencia y el indeterminismo) y la neurociencia.

Published
2020
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195. SARS-CoV-2 Fulminant Myocarditis

Author

Jérôme Garot, MD, PhD, Julien Amour, MD, PhD, Théo Pezel, MD, Firas Dermoch, MD, Kamel Messadaa, MD, Marie-Louise Felten, MD, Valérie Raymond, MD, Eric Baubillier, MD, Francesca Sanguineti, MD, and Philippe Garot, MD

Subjects
cardiac magnetic resonance, coronavirus disease 2019, myocarditis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

An 18-year-old male without prior medical history developed fulminant myocarditis concomitant to severe COVID-19 pneumonia, which was confirmed using serial cardiac magnetic resonance. This may have important diagnostic, monitoring, and pathogenic implications. (Level of Difficulty: Intermediate.)

Published
2020
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197. Determining the neutrino mass ordering and oscillation parameters with KM3NeT/ORCA

Author

Aiello, S., Albert, A., Alves Garre, S., Aly, Z., Ambrosone, A., Ameli, F., Andre, M., Androulakis, G., Anghinolfi, M., Anguita, M., Anton, G., Ardid, M., Ardid, S., Aublin, J., Bagatelas, C., Baret, B., Basegmez du Pree, S., Bendahman, M., Benfenati, F., Berbee, E., van den Berg, A. M., Bertin, V., Biagi, S., Bissinger, M., Boettcher, M., Bou Cabo, M., Boumaaza, J., Bouta, M., Bouwhuis, M., Bozza, C., Brânzaş, H., Bruijn, R., Brunner, J., Bruno, R., Buis, E., Buompane, R., Busto, J., Caiffi, B., Calvo, D., Capone, A., Carretero, V., Castaldi, P., Celli, S., Chabab, M., Chau, N., Chen, A., Cherubini, S., Chiarella, V., Chiarusi, T., Circella, M., Cocimano, R., Coelho, J. A. B., Coleiro, A., Colomer Molla, M., Coniglione, R., Coyle, P., Creusot, A., Cruz, A., Cuttone, G., Dallier, R., De Martino, B., De Palma, M., Di Marino, M., Di Palma, I., Díaz, A. F., Diego-Tortosa, D., Distefano, C., Domi, A., Donzaud, C., Dornic, D., Dörr, M., Drouhin, D., Eberl, T., Eddyamoui, A., van Eeden, T., van Eijk, D., El Bojaddaini, I., Elsaesser, D., Enzenhöfer, A., Espinosa, V., Fermani, P., Ferrara, G., Filipović, M. D., Filippini, F., Fusco, L. A., Gal, T., Garcia Soto, A., Garufi, F., Gatelet, Y., Geißelbrecht, N., Gialanella, L., Giorgio, E., Gozzini, S. R., Gracia, R., Graf, K., Grasso, D., Grella, G., Guderian, D., Guidi, C., Haefner, J., Hallmann, S., Hamdaoui, H., van Haren, H., Heijboer, A., Hekalo, A., Hennig, L., Hernández-Rey, J. J., Hofestädt, J., Huang, F., Idrissi Ibnsalih, W., Illuminati, G., James, C. W., de Jong, M., de Jong, P., Jung, B. J., Kadler, M., Kalaczyński, P., Kalekin, O., Katz, U. F., Khan Chowdhury, N. R., Kistauri, G., van der Knaap, F., Kooijman, P., Kouchner, A., Kreter, M., Kulikovskiy, V., Lahmann, R., Lamoureux, M., Larosa, G., Lastoria, C., Le Breton, R., Le Stum, S., Leonardi, O., Leone, F., Leonora, E., Lessing, N., Levi, G., Lincetto, M., Lindsey Clark, M., Lipreau, T., Longhitano, F., Lopez-Coto, D., Maderer, L., Mańczak, J., Mannheim, K., Margiotta, A., Marinelli, A., Markou, C., Martin, L., Martínez-Mora, J. A., Martini, A., Marzaioli, F., Mastroianni, S., Melis, K. W., Miele, G., Migliozzi, P., Migneco, E., Mijakowski, P., Miranda, L. S., Mollo, C. M., Morganti, M., Moser, M., Moussa, A., Muller, R., Musumeci, M., Nauta, L., Navas, S., Nicolau, C. A., Fearraigh, B. Ó., O’Sullivan, M., Organokov, M., Orlando, A., Palacios González, J., Papalashvili, G., Papaleo, R., Pastore, C., Păun, A. M., Păvălaş, G. E., Pellegrino, C., Perrin-Terrin, M., Pestel, V., Piattelli, P., Pieterse, C., Pikounis, K., Pisanti, O., Poirè, C., Popa, V., Pradier, T., Pühlhofer, G., Pulvirenti, S., Rabyang, O., Raffaelli, F., Randazzo, N., Razzaque, S., Real, D., Reck, S., Riccobene, G., Romanov, A., Rovelli, A., Salesa Greus, F., Samtleben, D. F. E., Sánchez Losa, A., Sanguineti, M., Santangelo, A., Santonocito, D., Sapienza, P., Schnabel, J., Schneider, M. F., Schumann, J., Schutte, H. M., Seneca, J., Sgura, I., Shanidze, R., Sharma, A., Sinopoulou, A., Spisso, B., Spurio, M., Stavropoulos, D., Stellacci, S. M., Taiuti, M., Tayalati, Y., Tenllado, E., Thiersen, H., Tingay, S., Tsourapis, V., Tzamariudaki, E., Tzanetatos, D., Van Elewyck, V., Vasileiadis, G., Versari, F., Vivolo, D., de Wasseige, G., Wilms, J., Wojaczyński, R., de Wolf, E., Yousfi, T., Zavatarelli, S., Zegarelli, A., Zito, D., Zornoza, J. D., Zúñiga, J., and Zywucka, N.

Published
2022
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198. Search for neutrino counterparts of gravitational-wave events detected by LIGO and Virgo during run O2 with the ANTARES telescope

Author

A. Albert, M. André, M. Anghinolfi, G. Anton, M. Ardid, J.-J. Aubert, J. Aublin, B. Baret, S. Basa, B. Belhorma, V. Bertin, S. Biagi, M. Bissinger, J. Boumaaza, M. Bouta, M. C. Bouwhuis, H. Brânzaş, R. Bruijn, J. Brunner, J. Busto, A. Capone, L. Caramete, J. Carr, S. Celli, M. Chabab, T. N. Chau, R. Cherkaoui El Moursli, T. Chiarusi, M. Circella, A. Coleiro, M. Colomer Molla, R. Coniglione, P. Coyle, A. Creusot, A. F. Díaz, G. de Wasseige, A. Deschamps, C. Distefano, I. Di Palma, A. Domi, C. Donzaud, D. Dornic, D. Drouhin, T. Eberl, N. El Khayati, A. Enzenhöfer, A. Ettahiri, P. Fermani, G. Ferrara, F. Filippini, L. Fusco, P. Gay, H. Glotin, R. Gozzini, R. Gracia Ruiz, K. Graf, C. Guidi, S. Hallmann, H. van Haren, A. J. Heijboer, Y. Hello, J. J. Hernández-Rey, J. Hößl, J. Hofestädt, F. Huang, G. Illuminati, C. W. James, M. de Jong, P. de Jong, M. Jongen, M. Kadler, O. Kalekin, U. Katz, N. R. Khan-Chowdhury, A. Kouchner, I. Kreykenbohm, V. Kulikovskiy, R. Lahmann, R. Le Breton, D. Lefèvre, E. Leonora, G. Levi, M. Lincetto, D. Lopez-Coto, S. Loucatos, G. Maggi, J. Manczak, M. Marcelin, A. Margiotta, A. Marinelli, J. A. Martínez-Mora, R. Mele, K. Melis, P. Migliozzi, M. Moser, A. Moussa, R. Muller, L. Nauta, S. Navas, E. Nezri, C. Nielsen, A. Nuñez-Castiñeyra, B. O’Fearraigh, M. Organokov, G. E. Păvălaş, C. Pellegrino, M. Perrin-Terrin, P. Piattelli, C. Poirè, V. Popa, T. Pradier, N. Randazzo, S. Reck, G. Riccobene, A. Sánchez-Losa, D. F. E. Samtleben, M. Sanguineti, P. Sapienza, F. Schüssler, M. Spurio, Th. Stolarczyk, B. Strandberg, M. Taiuti, Y. Tayalati, T. Thakore, S. J. Tingay, A. Trovato, B. Vallage, V. Van Elewyck, F. Versari, S. Viola, D. Vivolo, J. Wilms, D. Zaborov, A. Zegarelli, J. D. Zornoza, and J. Zúñiga

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract An offline search for a neutrino counterpart to gravitational-wave (GW) events detected during the second observation run (O2) of Advanced-LIGO and Advanced-Virgo performed with ANTARES data is presented. In addition to the search for long tracks induced by $$\nu _\mu $$ νμ ($${\overline{\nu }}_{\mu }$$ ν¯μ ) charged current interactions, a search for showering events induced by interactions of neutrinos of any flavour is conducted. The severe spatial and time coincidence provided by the gravitational-wave alert allows regions above the detector horizon to be probed, extending the ANTARES sensitivity over the entire sky. The results of this all-neutrino-flavour and all-sky time dependent analysis are presented. The search for prompt neutrino emission within ±500 s around the time of six GW events yields no neutrino counterparts. Upper limits on the neutrino spectral fluence and constraints on the isotropic energy radiated via high-energy neutrinos (from a few TeV to a few tens of PeV) are set for each GW event analysed.

Published
2020
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199. Refinement & validation of rectal wall dose volume objectives for prostate hypofractionation in 20 fractions

Author

Giuseppe Sanguineti, Adriana Faiella, Alessia Farneti, Pasqualina D'Urso, Valentina Fuga, Michela Olivieri, Diana Giannarelli, Simona Marzi, Giuseppe Iaccarino, and Valeria Landoni

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Background and purpose: Dose-volume objectives for the rectum have been proposed to limit long term toxicity after moderately hypofractionated radiotherapy (MHRT) for localized prostate cancer. The purpose of the present study is to validate and possibly refine dose volume objective for the rectal wall after 20-fraction MHRT. Materials and methods: All patients treated by 20-fraction MHRT at a single Institution were identified and relative rectal wall (%RW) DVH retrieved. The endpoint of the study is the development of grade 2+ late rectal bleeding (LRB) according to a modified RTOG scale. Clinical and dosimetric predictors of LRB were investigated at both uni- and multi-variable analysis. Results: 293 patients were identified and analyzed. Of them, 35 (12%) developed the endpoint. At univariable analysis, antithrombotic drug usage (yes vs no), technique (3DCRT vs IMRT/VMAT) and several %RW DVH cut-points were significantly correlated with LRB. However, within patients treated by 3DCRT (N = 106), a bi-variable model including anti-thrombotic drug usage and selected %RW dose/volume metrics failed to identify independent dosimetric predictors of LRB. Conversely, within patients treated with intensity modulation (N = 187), the same model showed a progressively higher impact of the percent of RW receiving doses above 40 Gy. Based on this model, we were able to confirm (V32), refine (V60) and identify a novel (V50) cut-point for the %RW. Conclusion: We recommend the following dose volume objectives for the %RW in order to minimize the risk of LRB after 20-fraction MHRT: V32 ≤ 50%; V50 ≤ 25.8% and V60 ≤ 10%. Keywords: Prostate cancer, Hypofractionation, Rectal bleeding, Rectal wall

Published
2020
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200. Dependence of atmospheric muon flux on seawater depth measured with the first KM3NeT detection units

Author

M. Ageron, S. Aiello, F. Ameli, M. Andre, G. Androulakis, M. Anghinolfi, G. Anton, M. Ardid, J. Aublin, C. Bagatelas, G. Barbarino, B. Baret, S. Basegmez du Pree, A. Belias, E. Berbee, A. M. van den Berg, V. Bertin, V. van Beveren, S. Biagi, A. Biagioni, S. Bianucci, M. Billault, M. Bissinger, R. de Boer, J. Boumaaza, S. Bourret, M. Bouta, M. Bouwhuis, C. Bozza, H. Brânzaş, M. Briel, M. Bruchner, R. Bruijn, J. Brunner, E. Buis, R. Buompane, J. Busto, G. Cacopardo, L. Caillat, C. Calì, D. Calvo, A. Capone, S. Celli, M. Chabab, N. Chau, S. Cherubini, V. Chiarella, T. Chiarusi, M. Circella, R. Cocimano, J. A. B. Coelho, A. Coleiro, M. Colomer Molla, S. Colonges, R. Coniglione, A. Cosquer, P. Coyle, A. Creusot, G. Cuttone, C. D’Amato, A. D’Amico, A. D’Onofrio, R. Dallier, M. De Palma, C. De Sio, I. Di Palma, A. F. Díaz, D. Diego-Tortosa, C. Distefano, A. Domi, R. Donà, C. Donzaud, L. van Dooren, D. Dornic, M. Dörr, M. Durocher, T. Eberl, T. van Eeden, I. El Bojaddaini, H. Eljarrari, D. Elsaesser, A. Enzenhöfer, P. Fermani, G. Ferrara, M. D. Filipović, L. A. Fusco, D. Gajanana, T. Gal, A. Garcia Soto, F. Garufi, L. Gialanella, E. Giorgio, A. Giuliante, S. R. Gozzini, R. Gracia, K. Graf, D. Grasso, T. Grégoire, G. Grella, A. Grimaldi, A. Grmek, D. Guderian, M. Guerzoni, C. Guidi, S. Hallmann, H. Hamdaoui, H. van Haren, A. Heijboer, A. Hekalo, S. Henry, J. J. Hernández-Rey, J. Hofestädt, F. Huang, E. Huesca Santiago, G. Illuminati, C. W. James, P. Jansweijer, M. Jongen, M. de Jong, P. de Jong, M. Kadler, P. Kalaczyński, O. Kalekin, U. F. Katz, F. Kayzel, P. Keller, N. R. Khan Chowdhury, F. van der Knaap, E. N. Koffeman, P. Kooijman, J. Koopstra, A. Kouchner, M. Kreter, V. Kulikovskiy, K. K. Meghna, R. Lahmann, P. Lamare, G. Larosa, J. Laurence, R. Le Breton, F. Leone, E. Leonora, G. Levi, F. Librizzi, M. Lincetto, P. Litrico, C. D. Llorens Alvarez, A. Lonardo, F. Longhitano, D. Lopez-Coto, G. Maggi, J. Mańczak, K. Mannheim, A. Margiotta, A. Marinelli, C. Markou, L. Martin, J. A. Martínez-Mora, A. Martini, F. Marzaioli, R. Mele, K. W. Melis, P. Migliozzi, E. Migneco, P. Mijakowski, L. S. Miranda, C. M. Mollo, M. Mongelli, M. Morganti, M. Moser, A. Moussa, R. Muller, P. Musico, M. Musumeci, L. Nauta, S. Navas, C. A. Nicolau, C. Nielsen, B. Ó Fearraigh, M. Organokov, A. Orlando, V. Panagopoulos, G. Pancaldi, G. Papalashvili, R. Papaleo, C. Pastore, G. E. Păvălaş, G. Pellegrini, C. Pellegrino, M. Perrin-Terrin, P. Piattelli, K. Pikounis, O. Pisanti, C. Poirè, G. Polydefki, V. Popa, M. Post, T. Pradier, G. Pühlhofer, S. Pulvirenti, L. Quinn, F. Raffaelli, N. Randazzo, A. Rapicavoli, S. Razzaque, D. Real, S. Reck, J. Reubelt, G. Riccobene, L. Rigalleau, G. Rizza, R. Rocco, A. Rovelli, J. Royon, M. Salemi, I. Salvadori, D. F. E. Samtleben, A. Sánchez Losa, M. Sanguineti, A. Santangelo, D. Santonocito, P. Sapienza, J. Schmelling, V. Sciacca, D. Sciliberto, J. Seneca, I. Sgura, R. Shanidze, A. Sharma, F. Simeone, A. Sinopoulou, B. Spisso, M. Spurio, D. Stavropoulos, J. Steijger, S. M. Stellacci, B. Strandberg, D. Stransky, T. Stüven, M. Taiuti, Y. Tayalati, E. Tenllado, D. Tézier, T. Thakore, S. Theraube, P. Timmer, S. Tingay, A. Trovato, S. Tsagkli, E. Tzamariudaki, D. Tzanetatos, C. Valieri, V. Van Elewyck, F. Versari, S. Viola, D. Vivolo, G. de Wasseige, J. Wilms, R. Wojaczyński, E. de Wolf, D. Zaborov, A. Zegarelli, J. D. Zornoza, and J. Zúñiga

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract KM3NeT is a research infrastructure located in the Mediterranean Sea, that will consist of two deep-sea Cherenkov neutrino detectors. With one detector (ARCA), the KM3NeT Collaboration aims at identifying and studying TeV–PeV astrophysical neutrino sources. With the other detector (ORCA), the neutrino mass ordering will be determined by studying GeV-scale atmospheric neutrino oscillations. The first KM3NeT detection units were deployed at the Italian and French sites between 2015 and 2017. In this paper, a description of the detector is presented, together with a summary of the procedures used to calibrate the detector in-situ. Finally, the measurement of the atmospheric muon flux between 2232–3386 m seawater depth is obtained.

Published
2020
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