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151. MnoxNanoenzyme Armed CAR‐NK Cells Enhance Solid Tumor Immunotherapy by Alleviating the Immunosuppressive Microenvironment

Author

Duan, Jiazhi, Zhao, Songbo, Duan, Yuyao, Sun, Dawei, Zhang, Gaorui, Yu, Dexin, Lou, Yalin, Liu, Huimin, Yang, Shanshan, Liang, Xiaohong, Ma, Chunhong, Liu, Hong, Qiu, Jichuan, Gao, Lifen, and Sang, Yuanhua

Abstract

Adoptively transferred cells usually suffer from exhaustion, limited expansion, and poor infiltration, partially attributing to the complicated immunosuppressive microenvironment of solid tumors. Therefore, it is necessary to explore more effective strategies to improve the poor tumor microenvironment (TME) to efficaciously deliver and support extrinsic effector cells in vivo. Herein, an intelligent biodegradable hollow manganese dioxide nanoparticle (MnOX) that possesses peroxidase activity to catalyze excess H2O2in the TME to produce oxygen and relieve the hypoxia of solid tumors is developed. MnOXnanoenzymes modified with CD56 antibody could specifically bind CAR‐NK (chimeric antigen receptor modified natural killer) cells. It is demonstrated that CAR‐NK cells incorporated with MnOXnanoenzymes effectively infiltrate into tumor tissues with an improved TME, which results in superior antitumor activity in solid tumor‐bearing mice. The antibody connection between MnOXnanoenzymes and CAR‐NK endows the lowest efficient dosage of MnOX. This study features a smart synergistic immunotherapy approach for solid tumors using MnOXnanoenzyme‐armed CAR‐NK cells, which would provide a valuable tool for immunocyte therapy in solid tumors. This research develops biocompatible MnOXnanozyme that could relieve the hypoxia and immunosuppression microenvironment of solid tumors. The MnOXnanozyme armed CAR‐NK cells could effectively deliver the backpack to tumor tissue and remodel the immune microenvironment, increasing CAR‐NK cells infiltration as well as effective magnetic resonance imaging, which features a synergistic immunotherapy approach for solid tumors.

Published
2024
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153. Tunable Layered (Na,Mn)V8O20·nH2O Cathode Material for High‐Performance Aqueous Zinc Ion Batteries.

Author

Du, Min, Liu, Chaofeng, Zhang, Feng, Dong, Wentao, Zhang, Xiaofei, Sang, Yuanhua, Wang, Jian‐Jun, Guo, Yu‐Guo, Liu, Hong, and Wang, Shuhua

Subjects
ZINC ions, MANGANESE, TRANSITION metal ions, ELECTRIC batteries, ENERGY consumption, ENERGY storage, AQUEOUS electrolytes, CATHODES
Abstract

Rechargeable aqueous zinc‐ion batteries (ZIBs) show promise for use in energy storage. However, the development of ZIBs has been plagued by the limited cathode candidates, which usually show low capacity or poor cycling performance. Here, a reversible Zn//(Na,Mn)V8O20·nH2O system is reported, the introduction of manganese (Mn) ions in NaV8O20 to form (Na,Mn)V8O20 exhibits an outstanding electrochemical performance with a capacity of 377 mA h g−1 at a current density of 0.1 A g−1. Through experimental and theoretical results, it is discovered that the outstanding performance of (Na,Mn)V8O20·nH2O is ascribed to the Mn2+/Mn3+‐induced high electrical conductivity and Na+‐induced fast migration of Zn2+. Other cathode materials derived from (Na,Mn)V8O20·nH2O by substituting Mn with Fe, Co, Ni, Ca, and K are explored to confirm the unique advantages of transition metal ions. With an increase in Mn content in NaV8O20, (Na0.33,Mn0.65)V8O20 ·nH2O can deliver a reversible capacity of 150 mA h g−1 and a capacity retention of 99% after 1000 cycles, which may open new opportunities for the development of high‐performance aqueous ZIBs. [ABSTRACT FROM AUTHOR]

Published
2020
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154. WSe2 2D p‐type semiconductor‐based electronic devices for information technology: Design, preparation, and applications.

Author

Cheng, Qilin, Pang, Jinbo, Sun, Dehui, Wang, Jingang, Zhang, Shu, Liu, Fan, Chen, Yuke, Yang, Ruiqi, Liang, Na, Lu, Xiheng, Ji, Yanchen, Wang, Jian, Zhang, Congcong, Sang, Yuanhua, Liu, Hong, and Zhou, Weijia

Abstract

The pioneering exfoliation of monolayer tungsten diselenide has greatly inspired researchers toward semiconducting applications. WSe2 belongs to a family of transition‐metal dichalcogenides. Similar to graphene, WSe2 and analogous dichalcogenides have layered structures with weak van der Waals interactions between two adjacent layers. First, the readers are presented with the fundamentals of WSe2, such as types, morphologies, and properties. Here, we report the characterization principles and practices such as microscopy, spectroscopy, and diffraction. Second, the methods for obtaining high‐quality WSe2, such as exfoliation, hydrothermal and chemical vapor deposition, are briefly listed. With advantages of light weight, flexibility, and high quantum efficiency, 2D materials may have a niche in optoelectronics as building blocks in p‐n junctions. Therefore, we introduce a state‐of‐the‐art demonstration of heterostructure devices employing the p‐type WSe2 semiconductor. The device architectures include field‐effect transistors, photodetectors, gas sensors, and photovoltaic solar cells. Due to its unique electronic, optical, and energy band properties, WSe2 has been increasingly investigated due to the conductivity of the p‐type charge carrier upon palladium contact. Eventually, the dynamic research on WSe2 and van der Waals heterostructures is summarized to arouse the passion of the 2D research community. [ABSTRACT FROM AUTHOR]

Published
2020
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178. Donor-acceptor Covalent Organic Framework/ZnIn2S4Core-shell Structure S-scheme Heterostructure for Efficient Photocatalytic Hydrogen Evolution

Author

Cui, Chao, Xu, Xin, Zhao, Xiaolei, Xi, Ning, Li, Mingtao, Wang, Xiaoning, Sang, Yuanhua, Yu, Xiaowen, Liu, Hong, and Wang, Jiahai

Abstract

Covalent organic frameworks (COFs) show promising prospect as the photocatalysts with advantages of exceptional light adsorption capabilities, large specific surface area, and adjustable band structure. However, COFs usually suffer from severe recombination of photogenerated carriers. Therefore, there is an urgent need to design effective COF-based heterostructures to enhance the separation of carriers. In this work, a porphyrin-based COF with electron donor-acceptor structure is synthesized viacondensation polymerization by using 5, 10, 15, 20-tetrakis (4-aminophenyl) porphyrin (TAPPP) and N, N, N, N-tetra(4-aldehydephenyl)-1, 4-phenylenediamine as the electron donor and acceptor, respectively. Subsequently, ZnIn2S4(ZIS) are successfully in-situgrown on the surface of porphyrin-based COF, forming a novel core-shell structure. The in-situ synthesized ZIS with positive charges can be easily adsorbed on the negatively charged sites of the COF’s surface via the electrostatic interaction. This organic/inorganic hybrid COF-ZIS heterostructure exhibits a superior photocatalytic hydrogen evolution (PHE) rate of 695 μmol g−1h−1, approximately three times higher than that of ZIS. The construction of COF-ZIS heterostructure played an important role in enhancing the separation and transport of photogenerated carriers, which provided more electrons at the surface of ZIS to take part in proton reduction. Electron paramagnetic resonance spectra confirm the charge carriers transfer mode in the COF-ZIS heterostructure via an S-scheme mechanism. Moreover, upon loading Pt as the cocatalyst, the heterostructure achieves an effective PHE rate of 2711 μmol g−1h−1along with an exceptional stability. Additionally, the COF-ZIS heterostructure reaches up to 2.45% of apparent quantum efficiency at 400nm. Notably, the average lifetime of the COF-ZIS heterostructure increases by 43.2% and 98.9% compared to that of ZIS and COF individually, as observed through single-particle fluorescence spectroscopy. This work gives valuable inspiration into the building of donor-acceptor COF-based S-scheme heterostructures to achieve highly effective green energy conversion by aligning band structures.

Published
2024
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179. Implantable Zinc Ion Battery and Osteogenesis-Immunoregulation Bifunction of Its Catabolite

Author

Zhang, Feng, Zheng, Yubo, Wang, Liang, Kang, Yongchao, Dong, Huitong, Li, Houzhen, Zhao, Xiaoru, Li, Boyan, Chen, Hao, Qiu, Jichuan, Sang, Yuanhua, Liu, Chao, Liu, Hong, and Wang, Shuhua

Abstract

Biocompatible batteries can power implantable electronic devices and have broad applications in medicine. However, the controlled degradation of implantable batteries, the impact of battery catabolites on surrounding tissues, and wireless charging designs are often overlooked. Here, we designed an implantable zinc ion battery (ZIB) using a gelatin/polycaprolactone-based composite gel electrolyte. The prepared ZIBs deliver a high specific capacity of 244.0 mA h g–1(0.5C) and long cycling stability of 300 cycles (4C). ZIBs were completely degraded within 8 weeks in rats and 30 days in a phosphate-buffered saline lipase solution, demonstrating good biocompatibility and degradability. ZIBs catabolites induced macrophage M2 polarization and exhibited anti-inflammatory properties, with mRNA levels of the M2 markers Arg-1 and CD206 up-regulated 15.8-fold and 13.4-fold, respectively, compared to the blank control group. Meanwhile, the expressions of two typical osteogenic markers, osteopontin and osteocalcin, were up-regulated by 3.6-fold and 5.6-fold, respectively, demonstrating that designed ZIBs promoted osteogenic differentiation of bone marrow mesenchymal stem cells. Additionally, a wireless energy transmission module was designed using 3D printing technology to realize real-time charging of the ZIB in rats. The designed ZIB is a promising power source for implantable medical electronic devices and also serves as a functional material to accelerate bone repair.

Published
2024
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180. Spontaneous and passive photoinduced charge carrier separation in CNT-ZnIn2S4network composites under a magnetic field

Author

Zhang, Wenkai, Zhao, Xiaolei, Liu, Qilu, Zhang, Mingxin, Xi, Ning, Cui, Chao, Yu, Xiaowen, Wang, Xiaoning, Wang, Yanmin, Liu, Hong, and Sang, Yuanhua

Abstract

Photoinduced charge carrier separation derived by magnetic fields has attracted increasing attention for its ability to wireless regulate powder photocatalysts. In this study, carbon nanotubes (CNT) were used as network conductors to link ZnIn2S4nanosheets. The electron highway in CNT spontaneously enhanced the photoinduced charge carrier transfer between ZnIn2S4nanosheets. The photocatalytic H2evolution rate of the 3 wt % CNT-ZIS composite increased to ∼210 % compared to that of pure ZIS under 300 W xenon lamp illumination. Additionally, in a magnetic field with relative motion, the Lorenz force on photoinduced electrons and holes suppressed their recombination, while the motional electromotive force along CNT accelerated the electron transfer to surface active sites. Therefore, the photocatalytic H2evolution rate further increased to 290 %. The spontaneous and passive photoinduced charge carrier separation in CNT-ZnIn2S4network composites under a magnetic field contributed to enhanced photocatalysis. Moreover, CNT-based network semiconductor composites can be mass-produced at low cost. Magnetic field-enhanced photocatalysis can be universally achieved without limitation caused by intrinsic band structures.

Published
2023
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187. Graphene Quantum Dots: Effects of Graphene Quantum Dots on the Self-Renewal and Differentiation of Mesenchymal Stem Cells (Adv. Healthcare Mater. 6/2016)

Author

Qiu, Jichuan, primary, Li, Deshuai, additional, Mou, Xiaoning, additional, Li, Jianhua, additional, Guo, Weibo, additional, Wang, Shu, additional, Yu, Xin, additional, Ma, Baojin, additional, Zhang, Shan, additional, Tang, Wei, additional, Sang, Yuanhua, additional, Gil, Pilar Rivera, additional, and Liu, Hong, additional

Published
2016
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197. Fluorescent graphene quantum dots as traceable, pH-sensitive drug delivery systems

Author

Qiu,Jichuan, Zhang,Ruibin, Li,Jianhua, Sang,Yuanhua, Tang,Wei, Rivera Gil,Pilar, Liu,Hong, Qiu,Jichuan, Zhang,Ruibin, Li,Jianhua, Sang,Yuanhua, Tang,Wei, Rivera Gil,Pilar, and Liu,Hong

Abstract

Jichuan Qiu,1 Ruibin Zhang,2 Jianhua Li,1 Yuanhua Sang,1 Wei Tang,3 Pilar Rivera Gil,4 Hong Liu1,51Center of Bio and Micro/Nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University, 2Blood Purification Center, Jinan Central Hospital, 3Department of Pathogenic Biology, Shandong University School of Medicine, Jinan, People’s Republic of China; 4Institute of Chemistry, Rovira i Virgili University, Tarragona, Spain; 5Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, People’s Republic of ChinaAbstract: Graphene quantum dots (GQDs) were rationally fabricated as a traceable drug delivery system for the targeted, pH-sensitive delivery of a chemotherapeutic drug into cancer cells. The GQDs served as fluorescent carriers for a well-known anticancer drug, doxorubicin (Dox). The whole system has the capacity for simultaneous tracking of the carrier and of drug release. Dox release is triggered upon acidification of the intracellular vesicles, where the carriers are located after their uptake by cancer cells. Further functionalization of the loaded carriers with targeting moieties such as arginine-glycine-aspartic acid (RGD) peptides enhanced their uptake by cancer cells. DU-145 and PC-3 human prostate cancer cell lines were used to evaluate the anticancer ability of Dox-loaded RGD-modified GQDs (Dox-RGD-GQDs). The results demonstrated the feasibility of using GQDs as traceable drug delivery systems with the ability for the pH-triggered delivery of drugs into target cells.Keywords: graphene quantum dots, drug delivery, pH-sensitive, controlled release, traceable

Published
2015

199. Conversion of solar power to chemical energy based on carbon nanoparticle modified photo-thermoelectric generator and electrochemical water splitting system.

Author

Zhang, Xiaofei, Gao, Wenqiang, Su, Xiaowen, Wang, Fulei, Liu, Baishan, Wang, Jian-Jun, Liu, Hong, and Sang, Yuanhua

Abstract

Nanogenerator has caused extensive attraction to convert/collect dispersive energy as electric energy. Solar thermoelectric generator (STEG), based on Seebeck effect of semiconductors, is one of the most promising approaches for solar energy conversion because of its simple structure, high stability and long lifetime. The light absorbers are of paramount importance for high-efficient STEG. In this work, high performance carbon nanoparticles for light harvesting have been synthesized via a facile and efficient method. By the in-situ coating of the nanoparticles on a commercial thermoelectric generator, a high-efficient STEG was constructed. The performance of the designed STEG device can be further improved with the integration of heat preservation and heat sink components. There is 34 times higher efficiency than that of the bare commercial thermoelectric generator, which enables an electrochemical process to generate hydrogen gas by water splitting. Be a kind of nanogenerator, this designed STEG devices provide a cheap and facile strategy for the portable power supply. [ABSTRACT FROM AUTHOR]

Published
2018
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200. Iron oxide embedded titania nanowires – An active and stable electrocatalyst for oxygen evolution in acidic media.

Author

Zhao, Lili, Cao, Qing, Wang, Aili, Duan, Jiazhi, Zhou, Weijia, Sang, Yuanhua, and Liu, Hong

Abstract

The hydrogen evolution reaction (HER) catalysts with high activity and stability in acid electrolyte are widely reported. However, the abundant, active and acidic stable catalysts for the oxygen evolution reaction (OER) are scarce to build the two-electrodes for water splitting. Fe-based materials are promising candidate electrocatalysts for OER in alkaline electrolyte, but unstable in acid electrolyte. Herein, some amount of iron oxides are incorporated into titanium dioxide nanowires (Fe-TiO x LNWs/Ti) by ion substitution and followed calcination process. The obtained Fe-TiO x LNWs/Ti lead to a moderate improved stability (81.3% vs. 33.3% for Fe 2 O 3 loaded on Ti foam at the same potential of 1.9 V vs. SCE for 20 h), and remain high activity for OER (a low onset potential of 1.49 V vs. RHE at 1 mA cm −2 ) in acid electrolyte. This study opens up the possibility and universality of active and abundant nonprecious metal oxides for OER utilized in acid electrolytes. [ABSTRACT FROM AUTHOR]

Published
2018
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