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1,220 results on '"Samuels M"'

152. Use of Hydrogels to Vaccinate Calves Orally for Pneumonic Pasteurellosis

Author

Bowersock, T. L., Shalaby, W. S. W., Samuels, M. L., White, M. R., Lalone, R., Levy, M., Ryker, D., and Park, K.

Subjects
Pneumonic pasteurellosis, Antigen, Immunity, business.industry, Immunogenicity, Self-healing hydrogels, technology, industry, and agriculture, food and beverages, Medicine, business, complex mixtures, Microbiology
Abstract

This study showed that hydrogels can deliver antigens orally to ruminants resulting in immunity at distant mucosal sites. Studies are underway to determine what other antigens can be loaded into hydrogels and retain their immunogenicity when released into the lower GIT. Hydrogels provide a practical, safe, economical way to deliver oral vaccines to a large number of animals to prevent diseases which begin at a mucosal surface., American Association of Bovine Practitioners Proceedings of the Annual Conference, 1992: Volume 1

Published
1992
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155. Fourteen cases of imposed upper airway obstruction

Author

Samuels, M P, McClaughlin, W, Jacobson, R R, Poets, C F, and Southall, D P

Subjects
Research Article
Abstract

Imposed upper airway obstruction was diagnosed as the cause of recurrent and severe cyanotic episodes in 14 patients. Episodes started between 0.8 and 33 months of age (median 1.4) and occurred over a period of 0.8 to 20 months (median 3.5). Diagnosis was made by covert video surveillance, instituted after either (a) the observation that episodes began only in the presence of one person, or (b) characteristic findings on physiological recordings, lasting between 12 hours and three weeks, performed in hospital or at home. Surveillance was undertaken for between 15 minutes and 12 days (median 24 hours) and resulted in safety for the patient and psychiatric assessment of the parent: mother (n = 12), father (n = 1), and grandmother (n = 1). These revealed histories of sexual, physical, or emotional abuse (n = 11), self harm (n = 9), factitious illness (n = 7), eating disorder (n = 10), and previous involvement with a psychiatrist (n = 7). Management of the abusing parents is complex, but recognition of their psychosocial characteristics may allow earlier diagnosis. Imposed upper airway obstruction should be considered and excluded by physiological recordings in any infant or young child with recurrent cyanotic episodes. If physiological recordings fail to substantiate a natural cause for episodes, covert video surveillance may be essential to protect the child from further injury or death.

Published
1992

161. Phase I study of irinotecan (Ir) and cisplatin (DDP) in combination with thoracic radiotherapy (RT), either twice daily (45 Gy) or once daily (70 Gy), in patients with limited (Ltd) small cell lung carcinoma (SCLC): Early analysis of RTOG 0241

Author

Langer, C. J., primary, Swann, S., additional, Werner-Wasik, M., additional, Lilenbaum, R., additional, Curran, W., additional, Sandler, A., additional, Scidmore, N., additional, Samuels, M., additional, and Choy, H., additional

Published
2006
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163. P-777 Phase I study of combination irinotecan and cisplatin and either twice daily thoracic radiation (45Gy) or once daily thoracic radiotherapy (70Gy) in patients with limited small cell lung carcinoma (SCLC): Early toxicity analysis of RTOG 0241

Author

Langer, C., primary, Swann, S., additional, Werner-Wasik, M., additional, Lillenbaum, R., additional, Curran, W., additional, Sandler, A., additional, Scidmore, N., additional, Choy, H., additional, and Samuels, M., additional

Published
2005
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167. IP-0038 A novel apoA-I mutation (Leu178Pro), identified by whole genome linkage approach, predisposes to endothelial dysfunction, increased arterial wall thickness and premature coronary artery disese

Author

Hovingh, G.K., primary, Bisoendial, R.J., additional, Brownlie, A., additional, Samuels, M., additional, Kuivenhoven, J.A., additional, De Groot, E., additional, Stroes, E.S.G., additional, Hayden, M.R., additional, and Kastelein, J.J.P., additional

Published
2003
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169. Sex-specific control of Sex-lethal is a conserved mechanism for sex determination in the genus Drosophila.

Author

Bopp, D, Calhoun, G, Horabin, J I, Samuels, M, Schedl, P, Bopp, D, Calhoun, G, Horabin, J I, Samuels, M, and Schedl, P

Abstract

In D. melanogaster the binary switch gene Sex-lethal (Sxl) plays a pivotal role in somatic sex determination -- when the Sxl gene is on the female pathway is followed, while the male pathway is followed when the gene is off. In the present study we have asked whether the Sxl gene is present in other species of the genus Drosophila and whether it is subject to a similar sex-specific on-off regulation. Sxl proteins were found in all of the drosophilids examined, and they display a sex-specific pattern of expression. Furthermore, characterization of the Sxl gene in the distant drosophilan relative, D. virilis, reveals that the structure and sequence organization of the gene has been well conserved and that, like melanogaster, alternative RNA processing is responsible for its sex-specific expression. Hence, this posttranscriptional on-off regulatory mechanism probably existed before the separation of the drosophilan and sophophoran subgenera and it seems likely that Sxl functions as a sex determination switch gene in most species in the Drosophila genus. Although alternative splicing appears to be responsible for the on-off regulation of the Sxl gene in D. virilis, this species is unusual in that Sxl proteins are present not only in females but also in males. The D. virilis female and male proteins appear to be identical over most of the length except for the amino-terminal approx. 25 aa which are encoded by the differentially spliced exons. In transcriptionally active polytene chromosomes, the male and female proteins bind to the same cytogenetic loci, including the sites corresponding to the D. virilis Sxl and tra genes. Hence, though the male proteins are able to interact with appropriate target pre-mRNAs, they are apparently incapable of altering the splicing pattern of these pre-mRNAs.

Published
1996

172. The coroner service

Author

Pilpel, J., primary, Charlton, R., additional, Samuels, M., additional, Sheikh, A., additional, Gatrad, A R, additional, Dhami, S., additional, Levitan, J., additional, and Dines, B. K, additional

Published
1999
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173. Two full-time parents.

Author

Samuels, M. Dee and Samuels, Michael

Subjects
Joint custody of children -- Management, Children of divorced parents -- Social aspects
Published
1993

184. Murder and Video Surveillance

Author

Shannon;, D. C., primary, Southall, D. P., additional, Plunkett, M. C. B., additional, Banks, M. W., additional, Falkov, A. F., additional, and Samuels, M. P., additional

Published
1998
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