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A case of a young manic patient who developed severe neurotoxicity when on lithium alone has been presented. Investigations did not reveal presence of any infection, electrolyte imbalance or rise in lithium level.The possibility of lithium producing neurotoxicity at therapeutic levels for as yet unknown reasons is pointed out. It is suggested that this element of risk be considered when starting lithium for therapy or prophylaxis of affective disorders.

In a study RBC-Plasma lithium ratios in manic patients treated with lithium we found that lithium responders had higher lithium ratios than lithium non-responders. There was, however, no cut off value which could differentiate lithium responders from non-responders.

In a Study Of 90 patients of Alcoholic Hallucinosis and 30 patients of Paranoid Schizophrenia, it was found that delusions, delusions of infidelity, third person and running commentary auditory hallucinations and insight were not different in the two groups.Delusions of grandeur, passivity, thought echo and thought broadcast were significantly more frequent in paranoid schizophrenic patients. Anxiety, visual iiafracinatians and hallucinations in more than one modality at the same time were commoner in alcoholic hallucionsis. Recovery from acute symptoms was much earlier in alcoholic hallucinosis.Number of first degree relatives with schizophrenia was much higher in the paranoid schizophrenic group.In a mean follow up period of 18 months, it was found that patients with alcoholic hallucinosis did much better than patients with paranoid schizophrenia.