151. Abstract 12773: Mobilization of Endothelial Progenitor Cells and Vessel Healing After Implantation of Abluminal Biodegradable Polymer Coating Everolimus-Eluting Stent
- Author
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Sakuma, Masashi, Nishino, Setsu, Kanaya, Tomoaki, Toyoda, Shigeru, Abe, Shichiro, and Inoue, Teruo
- Abstract
Backgrounds:Although drug-eluting stents have reduced restenosis, incomplete vessel healing at stented sites may be associated with adverse events. Bone marrow-derived progenitor cells likely contribute to both endothelial- and smooth muscle cell-dependent healing responses. This study was designed to compare the vessel healing process of abluminal biodegradable polymer coating everolimus-eluting stent (BP-PtCr-EES) with that of durable polymer everolimus-eluting stent (DP-PtCr-EES) in patients with acute coronary syndrome (ACS).Methods:In 58 patients with ACS, undergoing coronary stent implantation using the BP-PtCr-EES (Synergy?: n=40) or DP-PtCr-EES (Promus PREMIER?: n=18), we measured circulating CD34+/CD133+ cells and CD34+/KDR+ cells using flow cytometry, at baseline and at 7 days after stenting. At 12 months after stenting, we also observed neointimal thickness and neointimal coverage using optical coherence tomography (OCT). The neointimal coverage were also assessed by coronary angioscopy (CAS).Results:Circulating CD34+CD133+ cells increased at 7 days in BP-PtCr-EES group (P=0.0002), while it did not change significantly in DP-PtCr-EES group (P=0.059). The CD34+/KDR+ cells increased in both BP-PtCr-EES (P<0.0001) and DP-PtCr-EES (P=0.0005) groups. The OCT-based neointimal thickness (P=0.0004) and neointimal coverage rate (P=0.03) at 12 months was greater in BP-PtCr-EES group, compared with DP-PtCr-EES group. The CAS-based neointimal coverage grade at 12 months was also greater in BP-PtCr-EES group (P<0.01). In overall patients, the change in CD34+/KDR+ cells at 7 days showed significant positive correlation with that in OCT-based neointimal thickness at 12 months (R=0.292, P=0.0223).Conclusions:BP-PtCr-EES seems to have potential advantages over DP-PtCr-EES for ACS patients in terms of vessel healing process at the stented sites.
- Published
- 2019
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