151. Magneto-Electric Nano-Particles for Non-Invasive Brain Stimulation
- Author
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Jeongmin Hong, Kun Yue, Sakhrat Khizroev, Madhavan Nair, Ping Liang, and Rakesh Guduru
- Subjects
Anatomy and Physiology ,Clinical Research Design ,Deep Brain Stimulation ,Cognitive Neuroscience ,medicine.medical_treatment ,lcsh:Medicine ,Nanoparticle ,Biochemistry ,Neurological System ,Magnetics ,Alzheimer Disease ,Electric field ,Neural Pathways ,medicine ,Humans ,Nanotechnology ,Computer Simulation ,lcsh:Science ,Biology ,Magneto ,Computational Neuroscience ,Physics ,Multidisciplinary ,Neuromodulation ,business.industry ,lcsh:R ,Non invasive ,Modeling ,Brain ,Computational Biology ,Parkinson Disease ,Neurochemistry ,Magnetic field ,Transcranial magnetic stimulation ,Magnetic Fields ,Neurology ,Brain stimulation ,Nanoparticles ,Medicine ,Optoelectronics ,lcsh:Q ,Dementia ,Nerve Net ,Molecular Neuroscience ,business ,Magnetic dipole ,Research Article ,Neuroscience - Abstract
This paper for the first time discusses a computational study of using magneto-electric (ME) nanoparticles to artificially stimulate the neural activity deep in the brain. The new technology provides a unique way to couple electric signals in the neural network to the magnetic dipoles in the nanoparticles with the purpose to enable a non-invasive approach. Simulations of the effect of ME nanoparticles for non-invasively stimulating the brain of a patient with Parkinson's Disease to bring the pulsed sequences of the electric field to the levels comparable to those of healthy people show that the optimized values for the concentration of the 20-nm nanoparticles (with the magneto-electric (ME) coefficient of 100 V cm(-1) Oe(-1) in the aqueous solution) is 3 × 10(6) particles/cc, and the frequency of the externally applied 300-Oe magnetic field is 80 Hz.
- Published
- 2012