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1,037 results on '"STRINGER, ELIZABETH"'

151. Serologic surveillance of maternal Zika infection in a prospective cohort in Leon, Nicaragua during the peak of the Zika epidemic

Author

Collins, Matthew H., primary, Zepeda, Omar, additional, Blette, Bryan, additional, Jadi, Ramesh, additional, Morales, Marlen, additional, Pérez, Rigoberto, additional, Liou, Guei-Jiun Alice, additional, Montoya-Cruz, Magelda, additional, Harris, Eva, additional, Becker-Dreps, Sylvia, additional, de Silva, Aravinda M., additional, Stringer, Jeffrey, additional, Bucardo, Filemon, additional, and Stringer, Elizabeth, additional

Published
2020
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168. Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases

Author

de Jesus, Adriana A., Hou, Yangfeng, Brooks, Stephen, Malle, Louise, Biancotto, Angelique, Huang, Yan, Calvo, Katherine R., Marrero, Bernadette, Moir, Susan, Oler, Andrew J., Deng, Zuoming, Sanchez, Gina A. Montealegre, Ahmed, Amina, Allenspach, Eric, Arabshahi, Bita, Behrens, Edward, Benseler, Susanne, Bezrodnik, Liliana, Bout-Tabaku, Sharon, Brescia, AnneMarie C., Brown, Diane, Burnham, Jon M., Soledad Caldirola, Maria, Carrasco, Ruy, Chan, Alice Y., Cimaz, Rolando, Dancey, Paul, Dare, Jason, DeGuzman, Marietta, Dimitriades, Victoria, Ferguson, Ian, Ferguson, Polly, Finn, Laura, Gattorno, Marco, Grom, Alexei A., Hanson, Eric P., Hashkes, Philip J., Hedrich, Christian M., Herzog, Ronit, Horneff, Gerd, Jerath, Rita, Kessler, Elizabeth, Kim, Hanna, Kingsbury, Daniel J., Laxer, Ronald M., Lee, Pui Y., Lee-Kirsch, Min Ae, Lewandowski, Laura, Li, Suzanne, Lilleby, Vibke, Mammadova, Vafa, Moorthy, Lakshmi N., Nasrullayeva, Gulnara, O'Neil, Kathleen M., Onel, Karen, Ozen, Seza, Pan, Nancy, Pillet, Pascal, Piotto, Daniela G. P., Punaro, Marilynn G., Reiff, Andreas, Reinhardt, Adam, Rider, Lisa G., Rivas-Chacon, Rafael, Ronis, Tova, Roesen-Wolff, Angela, Roth, Johannes, Ruth, Natasha Mckerran, Rygg, Marite, Schmeling, Heinrike, Schulert, Grant, Scott, Christiaan, Seminario, Gisella, Shulman, Andrew, Sivaraman, Vidya, Son, Mary Beth, Stepanovskiy, Yuriy, Stringer, Elizabeth, Taber, Sara, Terreri, Maria Teresa, Tifft, Cynthia, Torgerson, Troy, Tosi, Laura, Van Royen-Kerkhof, Annet, Muskardin, Theresa Wampler, Canna, Scott W., Goldbach-Mansky, Raphaela, de Jesus, Adriana A., Hou, Yangfeng, Brooks, Stephen, Malle, Louise, Biancotto, Angelique, Huang, Yan, Calvo, Katherine R., Marrero, Bernadette, Moir, Susan, Oler, Andrew J., Deng, Zuoming, Sanchez, Gina A. Montealegre, Ahmed, Amina, Allenspach, Eric, Arabshahi, Bita, Behrens, Edward, Benseler, Susanne, Bezrodnik, Liliana, Bout-Tabaku, Sharon, Brescia, AnneMarie C., Brown, Diane, Burnham, Jon M., Soledad Caldirola, Maria, Carrasco, Ruy, Chan, Alice Y., Cimaz, Rolando, Dancey, Paul, Dare, Jason, DeGuzman, Marietta, Dimitriades, Victoria, Ferguson, Ian, Ferguson, Polly, Finn, Laura, Gattorno, Marco, Grom, Alexei A., Hanson, Eric P., Hashkes, Philip J., Hedrich, Christian M., Herzog, Ronit, Horneff, Gerd, Jerath, Rita, Kessler, Elizabeth, Kim, Hanna, Kingsbury, Daniel J., Laxer, Ronald M., Lee, Pui Y., Lee-Kirsch, Min Ae, Lewandowski, Laura, Li, Suzanne, Lilleby, Vibke, Mammadova, Vafa, Moorthy, Lakshmi N., Nasrullayeva, Gulnara, O'Neil, Kathleen M., Onel, Karen, Ozen, Seza, Pan, Nancy, Pillet, Pascal, Piotto, Daniela G. P., Punaro, Marilynn G., Reiff, Andreas, Reinhardt, Adam, Rider, Lisa G., Rivas-Chacon, Rafael, Ronis, Tova, Roesen-Wolff, Angela, Roth, Johannes, Ruth, Natasha Mckerran, Rygg, Marite, Schmeling, Heinrike, Schulert, Grant, Scott, Christiaan, Seminario, Gisella, Shulman, Andrew, Sivaraman, Vidya, Son, Mary Beth, Stepanovskiy, Yuriy, Stringer, Elizabeth, Taber, Sara, Terreri, Maria Teresa, Tifft, Cynthia, Torgerson, Troy, Tosi, Laura, Van Royen-Kerkhof, Annet, Muskardin, Theresa Wampler, Canna, Scott W., and Goldbach-Mansky, Raphaela

Abstract

BACKGROUND. Undifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments. METHODS. Sixty-six consecutively referred USAID patients underwent underwent screening for the presence of an interferon signature using a standardized type-I IFN-response-gene score (IRG-S), cytokine profiling, and genetic evaluation by next-generation sequencing. RESULTS. Thirty-six USAID patients (55%) had elevated IRG-S. Neutrophilic panniculitis (40% vs. 0%), basal ganglia calcifications (46% vs. 0%), interstitial lung disease (47% vs. 5%), and myositis (60% vs. 10%) were more prevalent in patients with elevated IRG-S. Moderate IRG-S elevation and highly elevated serum IL-18 distinguished 8 patients with pulmonary alveolar proteinosis (PAP) and recurrent macrophage activation syndrome (MAS). Among patients with panniculitis and progressive cytopenias, 2 patients were compound heterozygous for potentially novel LRBA mutations, 4 patients harbored potentially novel splice variants in IKBKG (which encodes NF-kappa B essential modulator [NEMO)), and 6 patients had de novo frameshift mutations in SAMD9L. Of additional 12 patients with elevated IRG-S and CANDLE-, SAVI- or Aicardi-Goutieres syndrome-like (AGS-like) phenotypes, 5 patients carried mutations in either SAMHD1, TREX1, PSMB8, or PSMG2. Two patients had anti-MDA5 autoantibody-positive juvenile dermatomyositis, and 7 could not be classified. Patients with LRBA, IKBKG, and SAMD9L mutations showed a pattern of IRG elevation that suggests prominent NF-kappa B activation different from the canonical interferonopathies CANDLE, SAVI, and AGS. CONCLUSIONS. In patients with elevated IRG-S, we identified characteristic clinical features and 3 additional autoinflammatory diseases: IL-18-mediated PAP and recurrent MAS (IL-18PAP-MAS), NEMO deleted exon 5- autoinflammatory syndrome (NEM

Published
2020

176. Parental Perspectives about Research and Knowledge Translation in Juvenile Idiopathic Arthritis

Author

Wright, Julia, primary, Curran, Janet, additional, Rose‐Davis, Benjamin, additional, Cellucci, Tania, additional, Duffy, Ciarån M., additional, Tucker, Lori B., additional, Batthish, Michelle, additional, Huber, Adam M., additional, Lang, Bianca, additional, Levy, Deborah M., additional, Rumsey, Dax G., additional, Watanabe Duffy, Karen N., additional, and Stringer, Elizabeth, additional

Published
2020
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177. Adverse birth outcomes and their clinical phenotypes in an urban Zambian cohort

Author

Price, Joan T, primary, Vwalika, Bellington, additional, Rittenhouse, Katelyn J, additional, Mwape, Humphrey, additional, Winston, Jennifer, additional, Freeman, Bethany L, additional, Sindano, Ntazana, additional, Stringer, Elizabeth M, additional, Kasaro, Margaret P, additional, Chi, Benjamin H, additional, and Stringer, Jeffrey SA, additional

Published
2020
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178. Clinical and associated inflammatory biomarker features predictive of short-term outcomes in non-systemic juvenile idiopathic arthritis

Author

Rezaei, Elham, primary, Hogan, Daniel, additional, Trost, Brett, additional, Kusalik, Anthony J, additional, Boire, Gilles, additional, Cabral, David A, additional, Campillo, Sarah, additional, Chédeville, Gaëlle, additional, Chetaille, Anne-Laure, additional, Dancey, Paul, additional, Duffy, Ciaran, additional, Watanabe Duffy, Karen, additional, Gordon, John, additional, Guzman, Jaime, additional, Houghton, Kristin, additional, Huber, Adam M, additional, Jurencak, Roman, additional, Lang, Bianca, additional, Morishita, Kimberly, additional, Oen, Kiem G, additional, Petty, Ross E, additional, Ramsey, Suzanne E, additional, Scuccimarri, Rosie, additional, Spiegel, Lynn, additional, Stringer, Elizabeth, additional, Taylor-Gjevre, Regina M, additional, Tse, Shirley M L, additional, Tucker, Lori B, additional, Turvey, Stuart E, additional, Tupper, Susan, additional, Yeung, Rae S M, additional, Benseler, Susanne, additional, Ellsworth, Janet, additional, Guillet, Chantal, additional, Karananayake, Chandima, additional, Muhajarine, Nazeem, additional, Roth, Johannes, additional, Schneider, Rayfel, additional, and Rosenberg, Alan M, additional

Published
2020
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180. Feasibility and safety of a 6-month exercise program to increase bone and muscle strength in children with juvenile idiopathic arthritis

Author

Houghton, Kristin M., Macdonald, Heather M., McKay, Heather A., Guzman, Jaime, Duffy, Ciarán, Tucker, Lori, Berard, Roberta, Boire, Gilles, Bruns, Alessandra, Campillo, Sarah, Chédeville, Gaëlle, Dancey, Paul, Ellsworth, Janet, Feldman, Debbie, Huber, Adam, Johnson, Nicole, Jurencak, Roman, Leblanc, Claire, Levy, Deborah, Miettunen, Paivi, Morishita, Kimberly, Ramsey, Suzanne, Rosenberg, Alan, Roth, Johannes, Rumsey, Dax, Schmeling, Heinrike, Scuccimarri, Rosie, Shiff, Natalie, and Stringer, Elizabeth

Subjects
Male, lcsh:Diseases of the musculoskeletal system, Childhood arthritis, Arthritis, Radius bone, Cohort Studies, 0302 clinical medicine, Absorptiometry, Photon, Quality of life, Bone Density, Immunology and Allergy, 030212 general & internal medicine, Longitudinal Studies, Quantitative computed tomography, Child, medicine.diagnostic_test, lcsh:RJ1-570, Exercise Therapy, medicine.anatomical_structure, Treatment Outcome, Muscle, Female, medicine.symptom, Exercise prescription, Research Article, medicine.medical_specialty, Canada, Adolescent, Juvenile arthritis, 03 medical and health sciences, Rheumatology, Internal medicine, medicine, Humans, Muscle Strength, Bone, Exercise, 030203 arthritis & rheumatology, business.industry, Physical activity, Muscle weakness, lcsh:Pediatrics, medicine.disease, Arthritis, Juvenile, Pediatrics, Perinatology and Child Health, Physical therapy, Quality of Life, Feasibility Studies, Patient Compliance, lcsh:RC925-935, business, Tomography, X-Ray Computed
Abstract

Background Arthritis in childhood can be associated with muscle weakness around affected joints, low bone mass and low bone strength. Exercise is recognized as an important part of management of children with juvenile idiopathic arthritis (JIA) but the exercise prescription to best promote bone and muscle health is unknown. We therefore aimed to: 1. assess feasibility and safety of a 6-month home- and group-based exercise program for children with JIA; 2. estimate the effect of program participation on bone mass and strength, muscle function and clinical outcomes and 3. determine if any positive changes in bone and muscle outcomes are maintained 6 months later. Methods We recruited 24 children with JIA who were part of the Linking Exercise, Physical Activity and Pathophysiology in Childhood Arthritis (LEAP) study to participate in a 6-month home-based exercise program involving jumping and handgrip exercises, resistance training and one group exercise session per month. We assessed lumbar spine bone mass (dual energy X-ray absorptiometry), distal tibia and radius bone microarchitecture and strength (high-resolution peripheral quantitative computed tomography), muscle function (jumping mechanography, dynamometry) and clinical outcomes (joint assessment, function, health-related quality of life) at baseline, 6- and 12-months. Adherence was assessed using weekly activity logs. Results Thirteen children completed the 6-month intervention. Participants reported 9 adverse events and post-exercise pain was rare (0.4%). Fatigue improved, but there were no other sustained improvements in muscle, bone or clinical outcomes. Adherence to the exercise program was low (47%) and decreased over time. Conclusion Children with JIA safely participated in a home-based exercise program designed to enhance muscle and bone strength. Fatigue improved, which may in turn facilitate physical activity participation. Prescribed exercise posed adherence challenges and efforts are needed to address facilitators and barriers to participation in and adherence to exercise programs among children with JIA. Trial registration Data of the children with JIA are from the LEAP study (Canadian Institutes of Health Research (CIHR; GRANT# 107535). http://www.leapjia.com/ Electronic supplementary material The online version of this article (10.1186/s12969-018-0283-4) contains supplementary material, which is available to authorized users.

Published
2018

184. Adverse birth outcomes and their clinical phenotypes in an urban Zambian cohort

Author

Price, Joan T, primary, Vwalika, Bellington, additional, Rittenhouse, Katelyn J, additional, Mwape, Humphrey, additional, Winston, Jennifer, additional, Freeman, Bethany L, additional, Sindano, Ntazana, additional, Stringer, Elizabeth M, additional, Kasaro, Margaret P, additional, Chi, Benjamin H, additional, and Stringer, Jeffrey SA, additional

Published
2019
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199. Development and Acceptability of a Patient Decision Aid for Pain Management in Juvenile Idiopathic Arthritis: The JIA Option Map.

Author

Toupin-April, Karine, Huber, Adam M., Duffy, Ciarán M., Proulx, Laurie, Morgan, Esi M., Cohen, Janice S., Gaboury, Isabelle, Li, Linda C., Tugwell, Peter, Stinson, Jennifer, the JIA Option Map Group, Couchman, Deema, Berbatovci, Fjolla, Boyd, Andrea, Sachs, Hannah, Sirois, Alexandra, Sivakumar, Aditi, Ragusa, Marco, El Hindi, Tania, and Stringer, Elizabeth

Published
2020
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