1,509 results on '"S. Woods"'
Search Results
152. Networked Memories
- Author
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Carly S. Woods
- Published
- 2019
153. Macrophages Shed Excess Cholesterol in Unique Extracellular Structures Containing Cholesterol Microdomains
- Author
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Xueting Jin, Janet Chang, Rhonda Flores, Erin Stempinski, Howard S. Kruth, Neta Varsano, Christian A. Combs, Amina S. Woods, Shelley N. Jackson, Ludovic Muller, Ying Liu, Lia Addadi, and Emilios K. Dimitriadis
- Subjects
Male ,0301 basic medicine ,Mice, Knockout, ApoE ,Microscopy, Atomic Force ,03 medical and health sciences ,chemistry.chemical_compound ,Membrane Microdomains ,homeostasis ,Cellular cholesterol ,Extracellular ,Animals ,Humans ,Cells, Cultured ,Basic Sciences ,Cholesterol ,Macrophages ,cholesterol ,Extracellular Matrix ,Cell biology ,Mice, Inbred C57BL ,030104 developmental biology ,Membrane ,Microscopy, Fluorescence ,chemistry ,ComputingMethodologies_DOCUMENTANDTEXTPROCESSING ,lipids (amino acids, peptides, and proteins) ,Microscopy, Electrochemical, Scanning ,fluorescence ,Efflux ,atherosclerosis ,Cardiology and Cardiovascular Medicine ,Homeostasis - Abstract
Supplemental Digital Content is available in the text., Objective— Cells use various mechanisms to maintain cellular cholesterol homeostasis including efflux of cholesterol from the cellular plasma membrane to cholesterol acceptors such as HDLs (high-density lipoproteins). Little is known about the transfer of cholesterol from cells into the extracellular matrix. Using a unique monoclonal antibody that detects ordered cholesterol arrays (ie, cholesterol micro[or nano]-domains), we previously identified that particles containing these cholesterol domains accumulate in the extracellular matrix during cholesterol enrichment of human monocyte-derived macrophages and are found in atherosclerotic lesions. In this study, we further investigate these deposited particles containing cholesterol microdomains and discover their unexpected morphology. Approach and Results— Although appearing spherical at the resolution of the conventional fluorescence microscope, super-resolution immunofluorescence and atomic force microscopy of in situ cholesterol microdomains, and immunoelectron microscopy of isolated cholesterol microdomains revealed that the microdomains are not vesicles or 3-dimensional crystals but rather appear as branching irregularly shaped deposits of varying size. These cholesterol microdomain-containing deposits are shed from the plasma membrane into the extracellular matrix. Conclusions— To date, research on cellular excretion of excess cholesterol has demonstrated cellular cholesterol efflux in the form of membranous vesicles and discoidal HDL particles released into the fluid-phase medium. Shedding of plasma membrane cholesterol microdomains provides an additional mechanism for cells such as macrophages to maintain plasma membrane cholesterol homeostasis. Furthermore, recognition that macrophages shed cholesterol microdomains into the extracellular matrix is important to our understanding of extracellular buildup of cholesterol in atherosclerosis.
- Published
- 2018
154. Alcohol Consumption and Risk of Coronary Artery Disease (from the Million Veteran Program)
- Author
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Rebecca J. Song, Xuan-Mai T. Nguyen, Rachel Quaden, Yuk-Lam Ho, Amy C. Justice, David R. Gagnon, Kelly Cho, Christopher J. O'Donnell, John Concato, J. Michael Gaziano, Luc Djoussé, Ildiko Halasz, Daniel Federman, Jean Beckham, Scott E. Sherman, Peruvemba Sriram, Philip S. Tsao, Edward J. Boyko, Junzhe Xu, Frank Lederle, Louis J. Dellitalia, Rachel McArdle, Laurence Kaminsky, Alan C. Swann, Mark B. Hamner, Hermes J. Florez, Prashant Pandya, Gerardo Villarreal, Peter Wilson, Timothy R. Morgan, Lori Davis, Robin A. Hurley, Laurence Meyer, Sunil K. Ahuja, Eric P. Konicki, David Cohen, Jack Lichy, Jeffrey Whittle, Kathlyn Sue Haddock, Karl D. Straub, John T. Callaghan, Samuel M. Aguayo, Samir Gupta, Ronald G. Washburn, Mary E. Oehlert, Adriana M. Hung, Agnes Wallbom, Robert Keith, Elif Sonel, Ronald B. Schifman, Richard D. Childress, Michael F. Godschalk, Alan R. Shuldiner, Padmashri Rastogi, Salvador Gutierrez, Ronald Fernando, Pran R. Iruvanti, Darshana Jhala, Carlos Rosado-Rodriguez, Stephen M. Mastorides, John B. Harley, Kristin Mattocks, Brooks Robey, Robert T. Striker, Michael Rauchman, John Wells, Zuhair K. Ballas, Susan S. Woods, Shing Shing Yeh, Nora R. Ratcliffe, Jon B. Klein, Adam G. Golden, Harold M. Ginzburg, Satish Sharma, Kris Ann K. Oursler, Mary A. Whooley, Gretchen Gibson, and null Heinz
- Subjects
Male ,medicine.medical_specialty ,Alcohol Drinking ,Population ,Coronary Artery Disease ,Alcohol use disorder ,030204 cardiovascular system & hematology ,Lower risk ,Article ,Coronary artery disease ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,education ,Aged ,Proportional Hazards Models ,Veterans ,education.field_of_study ,Proportional hazards model ,business.industry ,Alcoholic Beverages ,Hazard ratio ,Middle Aged ,Protective Factors ,medicine.disease ,United States ,Confidence interval ,Alcoholism ,Cardiology ,Female ,Self Report ,Cardiology and Cardiovascular Medicine ,business ,Body mass index ,Demography - Abstract
Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program participants. Using electronic health records, CAD events were defined as 1 inpatient or 2 outpatient diagnosis codes for CAD, or 1 code for a coronary procedure. We excluded participants with prevalent CAD (n = 69,995) or incomplete alcohol information (n = 8,449). We used a Cox proportional hazards model to estimate hazard ratios and 95% confidence intervals for CAD, adjusting for age, gender, body mass index, race, smoking, education, and exercise. Among 156,728 participants, the mean age was 65.3 years (standard deviation = 12.1) and 91% were men. There were 6,153 CAD events during a mean follow-up of 2.9 years. Adjusted hazard ratios (95% confidence intervals) for CAD were 1.00 (reference), 1.02 (0.92 to 1.13), 0.83 (0.74 to 0.93), 0.77 (0.67 to 0.87), 0.71 (0.62 to 0.81), 0.62 (0.51 to 0.76), 0.58 (0.46 to 0.74), and 0.95 (0.85 to 1.06) for categories of never drinker; former drinker; current drinkers of ≤0.5 drink/day, >0.5 to 1 drink/day, >1 to 2 drinks/day, >2 to 3 drinks/day, and >3 to 4 drinks/day; and heavy drinkers (>4 drinks/day) or alcohol use disorder, respectively. For a fixed amount of ethanol, intake at ≥3 days/week was associated with lower CAD risk compared with ≤1 day/week. Beverage preference (beer, wine, or liquor) did not influence the alcohol-CAD relation. Our data show a lower risk of CAD with light-to-moderate alcohol consumption among US veterans, and drinking frequency may provide a further reduction in risk.
- Published
- 2018
155. Wound Care Center of Excellence: A Process for Continuous Monitoring and Improvement of Wound Care Quality
- Author
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Jon S. Woods, Scott Gorenstein, Brian M. Gillette, Raelina S. Howell, Theresa Criscitelli, Virginia Donovan, and Lauren S Kohan
- Subjects
Male ,Chronic wound ,medicine.medical_specialty ,Quality management ,Process (engineering) ,media_common.quotation_subject ,Center of excellence ,MEDLINE ,Dermatology ,Patient Care Planning ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Wound care ,0302 clinical medicine ,Multidisciplinary approach ,medicine ,Humans ,Quality (business) ,Intensive care medicine ,Aged ,Monitoring, Physiologic ,Quality of Health Care ,media_common ,Patient Care Team ,Advanced and Specialized Nursing ,integumentary system ,business.industry ,Middle Aged ,Quality Improvement ,030220 oncology & carcinogenesis ,Chronic Disease ,Wounds and Injuries ,Female ,Interdisciplinary Communication ,medicine.symptom ,business - Abstract
GENERAL PURPOSE To provide information about a study using a new process for continuous monitoring to improve chronic wound care quality.This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.After completing this continuing education activity, you should be better able to:1. Recognize problems associated with chronic wound care.2. Identify methods used in this project to improve care.3. Illustrate the findings from this and similar projects and implications for providing improved wound care.Patients with chronic wounds require complex care because of comorbidities that can affect healing. Therefore, the goal of this project was to develop a system of reviewing all hospitalized patients seen by the study authors' wound care service on a weekly basis to decrease readmissions, morbidity, and mortality. Weekly multidisciplinary conferences were conducted to evaluate patient data and systematically assess for adherence to wound care protocols, as well as to create and modify patient care plans. This review of pathology and the performance of root-cause analyses often led to improved patient care.
- Published
- 2018
156. Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis
- Author
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Robert B. Hamanaka, Yufeng Tian, Brandon O. Ansbro, Gökhan M. Mutlu, Leah J. Witt, Parker S. Woods, Robert D. Guzy, David Wu, Recep Nigdelioglu, Angelo Y. Meliton, E.M. O'Leary, Nickolai O. Dulin, Jason M. Rohde, Shawn Ard, and Kaitlyn A. Sun
- Subjects
Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,Clinical Biochemistry ,Glycine ,Biology ,Bleomycin ,Serine ,Mice ,03 medical and health sciences ,Idiopathic pulmonary fibrosis ,chemistry.chemical_compound ,Transforming Growth Factor beta ,Fibrosis ,Pulmonary fibrosis ,medicine ,Animals ,Humans ,Phosphoglycerate dehydrogenase ,Enzyme Inhibitors ,Lung ,Molecular Biology ,Phosphoglycerate Dehydrogenase ,Original Research ,Cell Biology ,Fibroblasts ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,Mice, Inbred C57BL ,Disease Models, Animal ,030104 developmental biology ,chemistry ,NIH 3T3 Cells ,Cancer research ,Airway Remodeling ,Collagen ,Signal Transduction ,Transforming growth factor - Abstract
Organ fibrosis, including idiopathic pulmonary fibrosis, is associated with significant morbidity and mortality. Because currently available therapies have limited effect, there is a need to better understand the mechanisms by which organ fibrosis occurs. We have recently reported that transforming growth factor (TGF)-β, a key cytokine that promotes fibrogenesis, induces the expression of the enzymes of the de novo serine and glycine synthesis pathway in human lung fibroblasts, and that phosphoglycerate dehydrogenase (PHGDH; the first and rate-limiting enzyme of the pathway) is required to promote collagen protein synthesis downstream of TGF-β. In this study, we investigated whether inhibition of de novo serine and glycine synthesis attenuates lung fibrosis in vivo. We found that TGF-β induces mRNA and protein expression of PHGDH in murine fibroblasts. Similarly, intratracheal administration of bleomycin resulted in increased expression of PHGDH in mouse lungs, localized to fibrotic regions. Using a newly developed small molecule inhibitor of PHGDH (NCT-503), we tested whether pharmacologic inhibition of PHGDH could inhibit fibrogenesis both in vitro and in vivo. Treatment of murine and human lung fibroblasts with NCT-503 decreased TGF-β–induced collagen protein synthesis. Mice treated with the PHGDH inhibitor beginning 7 days after intratracheal instillation of bleomycin had attenuation of lung fibrosis. These results indicate that the de novo serine and glycine synthesis pathway is necessary for TGF-β–induced collagen synthesis and bleomycin-induced pulmonary fibrosis. PHGDH and other enzymes in the de novo serine and glycine synthesis pathway may be a therapeutic target for treatment of fibrotic diseases, including idiopathic pulmonary fibrosis.
- Published
- 2018
157. The Future of Data-Driven Wound Care
- Author
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Scott Gorenstein, Theresa Criscitelli, Brian M. Gillette, Tasha Nagamine, Raelina S. Howell, Mayur Saxena, and Jon S. Woods
- Subjects
Wound Healing ,business.industry ,Medical record ,Data Science ,Big data ,Information Storage and Retrieval ,medicine.disease ,Comorbidity ,Data-driven ,Machine Learning ,030207 dermatology & venereal diseases ,03 medical and health sciences ,Medical–Surgical Nursing ,Wound care ,0302 clinical medicine ,Workflow ,Health care ,Humans ,Wounds and Injuries ,Medicine ,030212 general & internal medicine ,Medical emergency ,business ,Overall efficiency - Abstract
Care for patients with chronic wounds can be complex, and the chances of poor outcomes are high if wound care is not optimized through evidence-based protocols. Tracking and managing every variable and comorbidity in patients with wounds is difficult despite the increasing use of wound-specific electronic medical records. Harnessing the power of big data analytics to help nurses and physicians provide optimized care based on the care provided to millions of patients can result in better outcomes. Numerous applications of machine learning toward workflow improvements, inpatient monitoring, outpatient communication, and hospital operations can improve overall efficiency and efficacy of care delivery in and out of the hospital, while reducing adverse events and complications. This article provides an overview of the application of big data analytics and machine learning in health care, highlights important recent advances, and discusses how these technologies may revolutionize advanced wound care.
- Published
- 2018
158. How High School Coursework Predicts Introductory College-Level Course Success
- Author
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Chenoa S. Woods, Shouping Hu, Tamara Betrand Jones, and Toby Park
- Subjects
Education reform ,College English ,Medical education ,business.industry ,education ,05 social sciences ,050301 education ,Placement testing ,Standardized test ,Academic achievement ,Academic advising ,Education ,Coursework ,0502 economics and business ,ComputingMilieux_COMPUTERSANDEDUCATION ,050207 economics ,Advanced Placement ,business ,Psychology ,0503 education - Abstract
Objective: In recent years, developmental education (DE) reform has led to a restructuring of the placement process, redesigning of course instructional modalities, or implementing student support services to supplement developmental coursework. In Florida, recent legislative changes allowed students to opt out of placement testing and enroll directly in college-level courses regardless of academic ability. The purpose of this study is to understand how students’ high school transcript information can be used in the academic advising process when students are no longer required to take standardized placement tests. Method: We used a combination of high school courses from statewide student-level data and conducted logistic regression analyses to understand how these courses help predict success in English Composition 1 and Intermediate Algebra. We also developed student profiles and presented predicted probabilities to illustrate how students with different combinations of high school coursework were pred...
- Published
- 2018
159. ATP catabolism by tissue nonspecific alkaline phosphatase contributes to development of ARDS in influenza-infected mice
- Author
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Parker S. Woods, Judy M. Hickman-Davis, Lauren M. Doolittle, and Ian C. Davis
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,ARDS ,Physiology ,Pulmonary Edema ,Inflammation ,Biology ,Virus Replication ,Mice ,03 medical and health sciences ,Adenosine Triphosphate ,Influenza A Virus, H1N1 Subtype ,Immune system ,Orthomyxoviridae Infections ,Physiology (medical) ,Nucleotidase ,medicine ,Animals ,5'-Nucleotidase ,Respiratory Distress Syndrome ,030102 biochemistry & molecular biology ,Catabolism ,virus diseases ,Cell Biology ,Alkaline Phosphatase ,medicine.disease ,Pulmonary edema ,Adenosine ,Mice, Inbred C57BL ,030104 developmental biology ,Immunology ,Alkaline phosphatase ,medicine.symptom ,Research Article ,medicine.drug - Abstract
Influenza A viruses are highly contagious respiratory pathogens that are responsible for significant morbidity and mortality worldwide on an annual basis. We have shown previously that influenza infection of mice leads to increased ATP and adenosine accumulation in the airway lumen. Moreover, we demonstrated that A1-adenosine receptor activation contributes significantly to influenza-induced acute respiratory distress syndrome (ARDS). However, we found that development of ARDS in influenza-infected mice does not require catabolism of ATP to adenosine by ecto-5′-nucleotidase (CD73). Hence, we hypothesized that increased adenosine generation in response to infection is mediated by tissue nonspecific alkaline phosphatase (TNAP), which is a low-affinity, high-capacity enzyme that catabolizes nucleotides in a nonspecific manner. In the current study, we found that whole lung and BALF TNAP expression and alkaline phosphatase enzymatic activity increased as early as 2 days postinfection (dpi) of C57BL/6 mice with 10,000 pfu/mouse of influenza A/WSN/33 (H1N1). Treatment at 2 and 4 dpi with a highly specific quinolinyl-benzenesulfonamide TNAP inhibitor (TNAPi) significantly reduced whole lung alkaline phosphatase activity at 6 dpi but did not alter TNAP gene or protein expression. TNAPi treatment attenuated hypoxemia, lung dysfunction, histopathology, and pulmonary edema at 6 dpi without impacting viral replication or BALF adenosine. Treatment also improved epithelial barrier function and attenuated cellular and humoral immune responses to influenza infection. These data indicate that TNAP inhibition can attenuate influenza-induced ARDS by reducing inflammation and fluid accumulation within the lung. They also further emphasize the importance of adenosine generation for development of ARDS in influenza-infected mice.
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- 2018
160. Interpersonal Relationships May Be a Vital Component of Culturally Competent Living Donor Kidney Transplantation Education Programs
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Vineeta Kumar, Alexis Carter, Christopher S. Woods, Rhiannon D. Reed, Grace E. Owens, Haiyan Qu, Alixandra C. Kale, and Jayme E. Locke
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Interpersonal relationship ,Nursing ,business.industry ,Component (UML) ,Medicine ,Surgery ,Culturally competent ,business ,medicine.disease ,Living donor ,Kidney transplantation - Published
- 2021
161. Contingent Faculty at Community Colleges: The Too-Often Overlooked and Under-Engaged Faculty Majority
- Author
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Kathryn Q. Thirolf and Rebekah S. Woods
- Subjects
0502 economics and business ,05 social sciences ,050301 education ,050207 economics ,Psychology ,0503 education - Published
- 2017
162. Laparoscopic Surgical Management of Symptomatic Anastomotic Ulcers after Gastric Bypass: A 10-Year Single-Center Experience
- Author
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Keneth, Hall, primary, Raelina S, Howell, additional, Patrizio, Petrone, additional, Javier, Perez-Calvo, additional, Jon S, Woods, additional, Harika, Boinpally, additional, Alexander, Barkan, additional, and Collin EM, Brathwaite, additional
- Published
- 2020
- Full Text
- View/download PDF
163. Single Stage Conversion from Laparoscopic Adjustable Gastric Band to Laparoscopic Sleeve Gastrectomy is Safer than Laparoscopic Adjustable Gastric Band to Roux-en-Y Gastric Bypass: Results of a 10-Year Analysis of Complications
- Author
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Raelina S., Howell, primary, Meredith, Akerman, additional, Patrizio, Petrone, additional, Javier, Perez-Calvo, additional, Harika, Boinpally, additional, Jon S, Woods, additional, Keneth, Hall, additional, Alexander, Barkan, additional, and Collin EM, Brathwaite, additional
- Published
- 2020
- Full Text
- View/download PDF
164. Mass Spectrometric Imaging of Ceramide Biomarkers Tracks Therapeutic Response in Traumatic Brain Injury
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Jeremy Post, J. Albert Schultz, Shelley N. Jackson, Aurelie Roux, Carey D. Balaban, Damon C. Barbacci, Amina S. Woods, Shawn Gouty, Kathrine Baldwin, Ludovic Muller, Barry Hoffer, and Brian M. Cox
- Subjects
Male ,0301 basic medicine ,Agonist ,Pathology ,medicine.medical_specialty ,Ceramide ,Physiology ,Traumatic brain injury ,medicine.drug_class ,Cognitive Neuroscience ,Ceramides ,Biochemistry ,Mass Spectrometry ,Article ,Rats, Sprague-Dawley ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Brain Injuries, Traumatic ,medicine ,Animals ,Cause of death ,Chemistry ,Diffuse axonal injury ,Therapeutic effect ,Brain Mass ,Brain ,Reproducibility of Results ,Cell Biology ,General Medicine ,medicine.disease ,Disease Models, Animal ,030104 developmental biology ,Brain Injuries ,Sphingomyelin ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Traumatic brain injury (TBI) is a serious public health problem and the leading cause of death in children and young adults. It also contributes to a substantial number of cases of permanent disability. As lipids make up over 50% of the brain mass and play a key role in both membrane structure and cell signaling, their profile is of particular interest. In this study, we show that advanced mass spectrometry imaging (MSI) has sufficient technical accuracy and reproducibility to demonstrate the anatomical distribution of 50 μm diameter microdomains that show changes in brain ceramide levels in a rat model of controlled cortical impact (CCI) 3 days post injury with and without treatment. Adult male Sprague-Dawley rats received one strike and were euthanized 3 days post trauma. Brain MS images showed increase in ceramides in CCI animals compared to control as well as significant reduction in ceramides in CCI treated animals, demonstrating therapeutic effect of a peptide agonist. The data also suggests the presence of diffuse changes outside of the injured area. These results shed light on the extent of biochemical and structural changes in the brain after traumatic brain injury and could help to evaluate the efficacy of treatments.
- Published
- 2017
165. Évaluation du respect des délais de déclaration dans le cadre d'un programme de lutte contre les maladies transmissibles destiné aux Premières nations
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N Ndubuka, S Woods, and A Lam
- Subjects
General Medicine - Published
- 2017
166. 218th ENMC International Workshop
- Author
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Richard S. Finkel, Thomas Sejersen, Eugenio Mercuri, E. Bertini, K. Chen, T.O. Crawford, V. Dubowitz, M. de Lemus, R. Graham, R. Hurst Davis, S. Iannaccone, J. Kirschner, M. Main, O. Mayer, E. Mazzone, J. Montes, F. Muntoni, A. Murphy, S. Quijano-Roy, A. Robertson, M. Schroth, A. Simonds, B. Snyder, M. Vitale, A. Wittchen, S. Woods, Y. Qian, and B. Wirth
- Subjects
medicine.medical_specialty ,Standard of care ,business.industry ,MEDLINE ,SMA ,03 medical and health sciences ,0302 clinical medicine ,Neurology ,030225 pediatrics ,Family medicine ,Pediatrics, Perinatology and Child Health ,medicine ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,Genetics (clinical) - Published
- 2017
167. Moving Rhetorica
- Author
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Michele Kennerly and Carly S. Woods
- Subjects
Linguistics and Language ,0508 media and communications ,Communication ,05 social sciences ,050801 communication & media studies - Published
- 2017
168. Laser Desorption/Ionization Mass Spectrometric Imaging of Endogenous Lipids from Rat Brain Tissue Implanted with Silver Nanoparticles
- Author
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Damon C. Barbacci, Amina S. Woods, Aurelie Roux, Michael I. Mccully, Carey D. Balaban, Kathrine Baldwin, Bruce E. Brinson, Ernest K. Lewis, Ludovic Muller, J. Albert Schultz, and Shelley N. Jackson
- Subjects
Male ,Ceramide ,Silver ,Metal Nanoparticles ,010402 general chemistry ,01 natural sciences ,Article ,Mass spectrometry imaging ,Silver nanoparticle ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Structural Biology ,Animals ,Phosphatidylinositol ,Spectroscopy ,Diacylglycerol kinase ,Brain Chemistry ,chemistry.chemical_classification ,Chromatography ,010401 analytical chemistry ,Fatty acid ,Lipids ,Rats ,0104 chemical sciences ,chemistry ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Cholesteryl ester ,Sphingomyelin - Abstract
Mass spectrometry imaging (MSI) of tissue implanted with silver nanoparticulate (AgNP) matrix generates reproducible imaging of lipids in rodent models of disease and injury. Gas-phase production and acceleration of size-selected 8 nm AgNP is followed by controlled ion beam rastering and soft landing implantation of 500 eV AgNP into tissue. Focused 337 nm laser desorption produces high quality images for most lipid classes in rat brain tissue (in positive mode: galactoceramides, diacylglycerols, ceramides, phosphatidylcholines, cholesteryl ester, and cholesterol, and in negative ion mode: phosphatidylethanolamides, sulfatides, phosphatidylinositol, and sphingomyelins). Image reproducibility in serial sections of brain tissue is achieved within10% tolerance by selecting argentated instead of alkali cationized ions. The imaging of brain tissues spotted with pure standards was used to demonstrate that Ag cationized ceramide and diacylglycerol ions are from intact, endogenous species. In contrast, almost all Ag cationized fatty acid ions are a result of fragmentations of numerous lipid types having the fatty acid as a subunit. Almost no argentated intact fatty acid ions come from the pure fatty acid standard on tissue. Graphical Abstract ᅟ.
- Published
- 2017
169. Use of fictional medical television in health sciences education: a systematic review
- Author
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Beth L. Hoffman, Brian A. Primack, Charles B. Wessel, Robert M. Hoffman, Ariel Shensa, and Michelle S. Woods
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Adult ,Male ,medicine.medical_specialty ,020205 medical informatics ,Health Personnel ,education ,Population ,02 engineering and technology ,PsycINFO ,CINAHL ,Education ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Continuing medical education ,Epidemiology ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Humans ,030212 general & internal medicine ,Nurse education ,Qualitative Research ,education.field_of_study ,Medical education ,Education, Medical ,General Medicine ,Educational research ,Family medicine ,Female ,Television ,Psychology ,Biomedical sciences - Abstract
While medical television programs are popular among health profession trainees, it is not clear to what extent these programs affect their knowledge, perceptions, and/or behaviors. Therefore, we conducted a systematic review of research evaluating associations between program exposure and outcomes. We conducted systematic literature searches in Pubmed, CINAHL, and PsycINFO. Selected studies were required to be scholarly research, involve exposure to fictionalized medical television programming by health professional students, and assess associations between exposure and outcomes. Studies were classified according to quality and factors related to population, exposure, and outcomes. Of 3541 studies identified, 13 met selection criteria. Six studies involved undergraduate medical students, one involved nursing students, two involved both medical and nursing students, two involved medical residents, one involved medical students, residents and attending physicians, and one involved graduate epidemiology students. Mean study quality according to the MERSQI was 8.27. The most commonly assessed television programs were ER and Grey's Anatomy (six each). Five studies assessed regular viewing habits, and found that fictional medical programs are popular among students and that students recall health topics from episodes. The eight studies that assessed the association with outcomes when using clips as educational tools reported high satisfaction and increased knowledge of the presented health topics. While relatively few published studies have explored influences of fictional medical television on health professional students, those conducted suggest that students often view these television programs independently and that integration of this programming into medical education is feasible and acceptable.
- Published
- 2017
170. Author Correction: Targeted exon skipping with AAV-mediated split adenine base editors
- Author
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Wendy S. Woods, Jackson Winter, Sony Manandhar, Pablo Perez-Pinera, Shraddha Shirguppe, Alan Luu, Michael Gapinske, and Jun S. Song
- Subjects
0303 health sciences ,lcsh:Cytology ,Published Erratum ,Cell Biology ,Computational biology ,Biology ,Base (topology) ,Biochemistry ,Exon skipping ,03 medical and health sciences ,0302 clinical medicine ,Genetics ,lcsh:QH573-671 ,Molecular Biology ,030217 neurology & neurosurgery ,030304 developmental biology - Abstract
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
- Published
- 2019
171. GOSSARD GIRLS ARE GOOD GIRLS
- Author
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Kristen Lucas and Carly S. Woods
- Subjects
Labour economics ,Factory (object-oriented programming) ,Sociology - Published
- 2019
172. A New Integrative Theory of Brain-Body-Ecosystem Medicine: From the Hippocratic Holistic View of Medicine to Our Modern Society
- Author
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Giovanna Calandra-Buonaura, Diego Guidolin, Deanna Anderlini, Luigi F. Agnati, Manuela Marcoli, Amina S. Woods, Pietro Cortelli, Guido Maura, Guidolin D., Anderlini D., Maura G., Marcoli M., Cortelli P., Calandra-Buonaura G., Woods A.S., and Agnati L.F.
- Subjects
integrative medicine ,depression, ecosystem, heart rate variabilit ,heart-brain interaction, inner speech, integrative medicine ,Health, Toxicology and Mutagenesis ,lcsh:Medicine ,heart-brain interaction ,Holistic Health ,Holistic health ,Safeguarding ,heart rate variabilit ,Article ,03 medical and health sciences ,symbols.namesake ,Human health ,0302 clinical medicine ,inner speech ,Humans ,Ecosystem ,Sociology ,030304 developmental biology ,Human Body ,Hippocratic Oath ,ecosystem ,0303 health sciences ,Ecosystem health ,lcsh:R ,technology, industry, and agriculture ,Public Health, Environmental and Occupational Health ,heart rate variability ,Brain ,Environmental ethics ,Human body ,depression ,symbols ,Integrative medicine ,030217 neurology & neurosurgery ,Human - Abstract
Humans are increasingly aware that their fate will depend on the wisdom they apply in interacting with the ecosystem. Its health is defined as the condition in which the ecosystem can deliver and continuously renew its fundamental services. A healthy ecosystem allows optimal interactions between humans and the other biotic/abiotic components, and only in a healthy ecosystem can humans survive and efficiently reproduce. Thus, both the human and ecosystem health should be considered together in view of their interdependence. The present article suggests that this relationship could be considered starting from the Hippocrates (460 BC&ndash, 370 BC) work &ldquo, On Airs, Waters, and Places&rdquo, to derive useful medical and philosophical implications for medicine which is indeed a topic that involves scientific as well as philosophical concepts that implicate a background broader than the human body. The brain-body-ecosystem medicine is proposed as a new more complete approach to safeguarding human health. Epidemiological data demonstrate that exploitation of the environment resulting in ecosystem damage affects human health and in several instances these diseases can be detected by modifications in the heart-brain interactions that can be diagnosed through the analysis of changes in heart rate variability.
- Published
- 2019
- Full Text
- View/download PDF
173. Targeted exon skipping with AAV-mediated split adenine base editors
- Author
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Sony Manandhar, Pablo Perez-Pinera, Jackson Winter, Michael Gapinske, Shraddha Shirguppe, Jun S. Song, Alan Luu, and Wendy S. Woods
- Subjects
Adenine deaminase ,Computational biology ,Biochemistry ,Article ,03 medical and health sciences ,Exon ,chemistry.chemical_compound ,0302 clinical medicine ,Adenosine deaminase ,Genetics ,splice ,lcsh:QH573-671 ,Molecular Biology ,Gene ,030304 developmental biology ,0303 health sciences ,biology ,lcsh:Cytology ,Chemistry ,Biological techniques ,Correction ,Cell Biology ,Exon skipping ,DNA glycosylase ,biology.protein ,Transcription ,030217 neurology & neurosurgery ,DNA - Abstract
Techniques for exclusion of exons from mature transcripts have been applied as gene therapies for treating many different diseases. Since exon skipping has been traditionally accomplished using technologies that have a transient effect, it is particularly important to develop new techniques that enable permanent exon skipping. We have recently shown that this can be accomplished using cytidine base editors for permanently disabling the splice acceptor of target exons. We now demonstrate the application of CRISPR-Cas9 adenine deaminase base editors to disrupt the conserved adenine within splice acceptor sites for programmable exon skipping. We also demonstrate that by altering the amino acid sequence of the linker between the adenosine deaminase domain and the Cas9-nickase or by coupling the adenine base editor with a uracil glycosylase inhibitor, the DNA editing efficiency and exon-skipping rates improve significantly. Finally, we developed a split base editor architecture compatible with adeno-associated viral packaging. Collectively, these results represent significant progress toward permanent in vivo exon skipping through base editing and, ultimately, a new modality of gene therapy for the treatment of genetic diseases.
- Published
- 2019
174. Author response: Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion
- Author
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Tsung-Ping Su, Shelley N. Jackson, Amina S. Woods, Sachin Patel, Dan P. Covey, Yuko Yasui, Yoki Nakamura, Carl R. Lupica, Yuriko Kimura, Dilyan I. Dryanovski, and Shang-Yi Tsai
- Subjects
Chemistry ,Sigma ,Secretion ,Extracellular vesicle ,Receptor ,Endocannabinoid system ,Cell biology - Published
- 2019
175. Complete dissolution of solid matrices using automated borate fusion in support of nuclear decommissioning and production of reference materials
- Author
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David Read, Emma Braysher, P. Ivanov, M. García-Miranda, B. Bouchard, S. Woods, and Ben Russell
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Radionuclide ,Fusion ,business.industry ,Health, Toxicology and Mutagenesis ,Sample (material) ,Public Health, Environmental and Occupational Health ,Sample mass ,chemistry.chemical_element ,010403 inorganic & nuclear chemistry ,01 natural sciences ,Pollution ,Nuclear decommissioning ,0104 chemical sciences ,Analytical Chemistry ,Nuclear Energy and Engineering ,chemistry ,Environmental science ,Radiology, Nuclear Medicine and imaging ,Sample preparation ,Process engineering ,business ,Boron ,Dissolution ,Spectroscopy - Abstract
Accurate measurement of natural and anthropogenic radionuclide concentrations is of critical importance to end users in the nuclear sector to ensure correct classification prior to storage, recycling, reprocessing or disposal. Uncertainties in the characterisation of solid matrices and materials could lead to safety, quality and financial implications. Robust sample preparation methods are vital, in particular effective sample digestion, as under-estimated chemical yield recovery results in a corresponding under-estimation of activity levels. Borate fusion has been proven to effectively digest a range of complex sample matrices in the geosciences but is not used routinely elsewhere. In this study, we describe an automated procedure for borate fusion of multiple matrices encountered in nuclear decommissioning, containing diverse radionuclides over a range of activity concentrations. The impact of digestion flux, sample mass and sample to flux ratios are described, as well as the subsequent separation and measurement techniques. The results contribute to accurate and precise measurement of radionuclides in various matrices, as well as to characterisation of reference materials, providing greater confidence in nuclear industry programmes worldwide.
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- 2019
176. Particulate Matter Induces the Expression of Aconitate Decarboxylase 1, Which by Its Metabolite Itaconate Attenuates Inflammatory Response in Macrophages
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Angelo Y. Meliton, Parker S. Woods, David Wu, Lucas M. Kimmig, E.M. O'Leary, Kaitlyn A. Sun, Gökhan M. Mutlu, Robert B. Hamanaka, and Yufeng Tian
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chemistry.chemical_compound ,chemistry ,Biochemistry ,Inflammatory response ,Metabolite ,Aconitate decarboxylase ,Particulates - Published
- 2019
177. Inhibition of Phosphoglycerate Kinase 1 Attenuates Particulate Matter-Induced Pro-Inflammatory Cytokine Production in Macrophages
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Yufeng Tian, Robert B. Hamanaka, Parker S. Woods, Kaitlyn A. Sun, Jae Won Chang, Gökhan M. Mutlu, Lucas M. Kimmig, Angelo Y. Meliton, D. Zhao, and R.E. Moellering
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education.field_of_study ,Cytokine ,Chemistry ,medicine.medical_treatment ,medicine ,Particulates ,Phosphoglycerate kinase 1 ,education ,Cell biology - Published
- 2019
178. Influenza, Lipopolysaccharide, and Particulate Matter Treatment Result in Distinct Metabolic Alterations in Macrophages
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Parker S. Woods, Kaitlyn A. Sun, Robert B. Hamanaka, Gökhan M. Mutlu, Angelo Y. Meliton, and Lucas M. Kimmig
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chemistry.chemical_compound ,Lipopolysaccharide ,chemistry ,Treatment results ,Particulates ,Microbiology - Published
- 2019
179. Glutamine Metabolism Supports Collagen Protein Synthesis in Human Lung Fibroblasts
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Robert B. Hamanaka, Gökhan M. Mutlu, Yufeng Tian, L.J. Witt, Lucas M. Kimmig, Angelo Y. Meliton, Recep Nigdelioglu, E.M. O'Leary, Parker S. Woods, Nickolai O. Dulin, David Wu, Kaitlyn A. Sun, and G. Gokalp
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medicine.anatomical_structure ,Biochemistry ,Chemistry ,Glutamine metabolism ,Protein biosynthesis ,medicine ,Human lung - Published
- 2019
180. Stimulation of the Na+/K+-ATPase Leads to a Differential Response in Bone Marrow-Derived Macrophages
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Robert B. Hamanaka, Gökhan M. Mutlu, Kaitlyn A. Sun, E.M. O'Leary, Angelo Y. Meliton, Parker S. Woods, Yufeng Tian, and Lucas M. Kimmig
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medicine.anatomical_structure ,Chemistry ,medicine ,Stimulation ,Bone marrow ,Na+/K+-ATPase ,Molecular biology ,Differential (mathematics) - Published
- 2019
181. De Novo Proline Synthesis Promotes Collagen Production in Human Lung Fibroblasts
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E.M. O'Leary, Gökhan M. Mutlu, Recep Nigdelioglu, Parker S. Woods, David Wu, Yufeng Tian, Kaitlyn A. Sun, Nickolai O. Dulin, Leah J. Witt, G. Gokalp, Lucas M. Kimmig, Angelo Y. Meliton, and Robert B. Hamanaka
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medicine.anatomical_structure ,Chemistry ,Proline synthesis ,medicine ,Molecular biology ,Human lung - Published
- 2019
182. Histidine, the less interactive cousin of arginine
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Ludovic Muller, Shelley N. Jackson, and Amina S. Woods
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Spectrometry, Mass, Electrospray Ionization ,Arginine ,Stereochemistry ,Static Electricity ,Molecular Conformation ,01 natural sciences ,Epitope ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,Non-covalent interactions ,Histidine ,Amino acid residue ,Spectroscopy ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,010401 analytical chemistry ,General Medicine ,ESI mass spectrometry ,Salt bridge (protein and supramolecular) ,Phosphate ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,chemistry ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Peptides ,Protein Processing, Post-Translational - Abstract
Electrostatic interactions are one of the main factors influencing biomolecular conformation. The formation of noncovalent complexes by electrostatic interactions is governed by certain amino acid residues and post-translational modifications. It has been demonstrated that adjacent arginine forms noncovalent complex with phosphate; however, histidine noncovalent complexes have rarely been investigated. In the present work, we compare the interaction between basic epitopes (NLRRITRVN, SHHGLHSTPD) and diverse acidic and aromatic-rich peptides using both MALDI and ESI Mass spectrometry. We show that adjacent histidines can also form stable noncovalent bonds and that those bonds are probably formed by a salt bridge between the phosphate or the acid residues and the histidines. However, noncovalent complexes with the arginine epitopes form more readily and are stronger than those with histidine-containing epitopes.
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- 2019
183. Mechanization of smallholders in Sub-Saharan Africa by agrodealer development
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G.R. Barlow, J. Burbidge, P.A. Misiewicz, S. Peets, S. Woods, and B. Ngwene
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Geography ,Sub saharan ,Agroforestry ,Mechanization - Published
- 2019
184. Search for long-lived particles using nonprompt jets and missing transverse momentum with proton-proton collisions at root s=13 TeV
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Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Brandstetter, J. Dragicevic, M. Eroe, J. and Del Valle, A. Escalante Flechl, M. Fruehwirth, R. Jeitler, M. Krammer, N. Kraetschmer, I Liko, D. Madlener, T. and Mikulec, I Rad, N. Schieck, J. Schoefbeck, R. Spanring, M. Spitzbart, D. Waltenberger, W. Wulz, C-E Zarucki, M. and Drugakov, V Mossolov, V Gonzalez, J. Suarez Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. Lelek, A. and Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. D'Hondt, J. De Clercq, J. Lontkovskyi, D. Lowette, S. Marchesini, I Moortgat, S. Moreels, L. and Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. and Van Mulders, P. Van Parijs, I Beghin, D. Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. Delannoy, H. Dorney, B. Favart, L. Grebenyuk, A. Kalsi, A. K. Popov, A. and Postiau, N. Starling, E. Thomas, L. Vander Velde, C. and Vanlaer, P. Vannerom, D. Cornelis, T. Dobur, D. and Khvastunov, I Niedziela, M. Roskas, C. Trocino, D. and Tytgat, M. Verbeke, W. Vermassen, B. Vit, M. Zaganidis, N. Bondu, O. Bruno, G. Caputo, C. David, P. Delaere, C. Delcourt, M. Giammanco, A. Lemaitre, V Magitteri, A. and Prisciandaro, J. Saggio, A. Marono, M. Vidal Vischia, P. and Zobec, J. Alves, F. L. Alves, G. A. Correia Silva, G. and Hensel, C. Moraes, A. Rebello Teles, P. Belchior Batista Das Chagas, E. Carvalho, W. Chinellato, J. Coelho, E. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Huertas Guativa, L. M. and Malbouisson, H. Martins, J. Matos Figueiredo, D. Medina Jaime, M. Melo De Almeida, M. Mora Herrera, C. Mundim, L. and Nogima, H. Prado Da Silva, W. L. Sanchez Rosas, L. J. and Santoro, A. Sznajder, A. Thiel, M. Tonelli Manganote, E. J. and Torres Da Silva De Araujo, F. Vilela Pereira, A. Bernardes, C. A. Calligaris, L. Fernandez Perez Tomei, T. R. Gregores, E. M. Lemos, D. S. Mercadante, P. G. Novaes, S. F. and Padula, Sandra S. Aleksandrov, A. Antchev, G. Hadjiiska, R. and Iaydjiev, P. Marinov, A. Misheva, M. Rodozov, M. and Shopova, M. Sultanov, G. Bonchev, M. Dimitrov, A. and Ivanov, T. Litov, L. Pavlov, B. Petkov, P. Fang, W. and Gao, X. Yuan, L. Ahmad, M. Chen, G. M. Chen, H. S. and Chen, M. Jiang, C. H. Leggat, D. Liao, H. Liu, Z. and Shaheen, S. M. Spiezia, A. Tao, J. Yazgan, E. Zhang, H. and Zhang, S. Zhao, J. Agapitos, A. Ban, Y. Chen, G. and Levin, A. Li, J. Li, L. Li, Q. Mao, Y. Qian, S. J. and Wang, D. Wang, Q. Hu, Z. Wang, Y. Avila, C. and Cabrera, A. Chaparro Sierra, L. F. Florez, C. Gonzalez Hernandez, C. F. Segura Delgado, M. A. Mejia Guisao, J. Ruiz Alvarez, J. D. Salazar Gonzalez, C. A. Vanegas Arbelaez, N. and Giljanovic, D. Godinovic, N. Lelas, D. Puljak, I Sculac, T. Antunovic, Z. Kovac, M. Brigljevic, V Ceci, S. and Ferencek, D. Kadija, K. Mesic, B. Roguljic, M. and Starodumov, A. Susa, T. Ather, M. W. Attikis, A. and Erodotou, E. Ioannou, A. Kolosova, M. Konstantinou, S. and Mavromanolakis, G. Mousa, J. Nicolaou, C. Ptochos, F. and Razis, P. A. Rykaczewski, H. Tsiakkouri, D. Finger, M. and Fingera, Jr., M. Kveton, A. Tomsa, J. Ayala, E. Jarrin, E. Carrera Assran, Y. Elgammal, S. Bhowmik, S. De Oliveira, A. Carvalho Antunes Dewanjee, R. K. Ehataht, K. and Kadastik, M. Raidal, M. Veelken, C. Eerola, P. and Forthomme, L. Kirschenmann, H. Osterberg, K. Voutilainen, M. and Garcia, F. Havukainen, J. Heikkila, J. K. Jarvinen, T. and Karimaki, V Kinnunen, R. Lampen, T. Lassila-Perini, K. and Laurila, S. Lehti, S. Lindn, T. Luukka, P. Maenpaa, T. Siikonen, H. Tuominen, E. Tuominiemi, J. Tuuva, T. and Besancon, M. Couderc, F. Dejardin, M. Denegri, D. and Fabbro, B. Faure, J. L. Ferri, F. Ganjour, S. Givernaud, A. Gras, P. de Monchenault, G. Hamel Jarry, P. Leloup, C. Locci, E. Malcles, J. Rander, J. Rosowsky, A. and Savoy-Navarro, A. Titov, M. O. Ahuja, S. Amendola, C. and Beaudette, F. Busson, P. Charlot, C. Diab, B. Falmagne, G. de Cassagnac, R. Granier Kucher, I Lobanov, A. Perez, C. Martin Nguyen, M. Ochando, C. Paganini, P. Rembser, J. Salerno, R. Sauvan, J. B. Sirois, Y. Zabi, A. and Zghiche, A. Agram, J-L Andrea, J. Bloch, D. Bourgatte, G. Brom, J-M Chabert, E. C. Collard, C. Conte, E. and Fontaine, J-C Gel, D. Goerlach, U. Jansova, M. Le Bihan, A-C Tonon, N. Van Hove, P. Gadrat, S. Beauceron, S. and Bernet, C. Boudoul, G. Camen, C. Chanon, N. Chierici, R. and Contardo, D. Depasse, P. El Mamouni, H. Fay, J. and Gascon, S. Gouzevitch, M. Ille, B. Jain, Sa Lagarde, F. and Laktineh, I. B. Lattaud, H. Lethuillier, M. Mirabito, L. and Perries, S. Sordini, V Touquet, G. Vander Donckt, M. and Viret, S. Khvedelidze, A. Tsamalaidze, Z. Autermann, C. and Feld, L. Kiesel, M. K. Klein, K. Lipinski, M. Meuser, D. and Pauls, A. Preuten, M. Rauch, M. P. Schomakers, C. and Schulz, J. Teroerde, M. Wittmer, B. Albert, A. Erdmann, M. Erdweg, S. Esch, T. Fischer, B. Fischer, R. and Ghosh, S. Hebbeker, T. Hoepfner, K. Keller, H. and Mastrolorenzo, L. Merschmeyer, M. Meyer, A. Millet, P. and Mocellin, G. Mondal, S. Mukherjee, S. Noll, D. Novak, A. and Pook, T. Pozdnyakov, A. Quast, T. Radziej, M. Rath, Y. Reithler, H. Rieger, M. Roemer, J. Schmidt, A. and Schuler, S. C. Sharma, A. Ther, S. Wiedenbeck, S. Flgge, G. Ahmad, W. Haj Hlushchenko, O. Kress, T. Mller, T. and Nehrkorn, A. Nowack, A. Pistone, C. Pooth, O. Roy, D. and Sert, H. Stahl, A. Martin, M. Aldaya Asmuss, P. and Babounikau, I Bakhshiansohi, H. Beernaert, K. Behnke, O. and Behrens, U. Martinez, A. Bermudez Bertsche, D. Bin Anuar, A. A. Borras, K. Botta, V Campbell, A. Cardini, A. and Connor, P. Rodriguez, S. Consuegra Contreras-Campana, C. and Danilov, V De Wit, A. Defranchis, M. M. Pardos, C. Diez and Damiani, D. Domnguez Eckerlin, G. Eckstein, D. Eichhorn, T. and Elwood, A. Eren, E. Gallo, E. Geiser, A. Luyando, J. M. Grados Grohsjean, A. Guthoff, M. Haranko, M. Harb, A. and Jafari, A. Jomhari, N. Z. Jung, H. Kasem, A. and Kasemann, M. Kaveh, H. Keaveney, J. Kleinwort, C. and Knolle, J. Kruecker, D. Lange, W. Lenz, T. Leonard, J. and Lidrych, J. Lipka, K. Lohmann, W. Mankel, R. and Melzer-Pellmann, I-A Meyer, A. B. Meyer, M. Missiroli, M. and Mittag, G. Mnich, J. Mussgiller, A. Myronenko, V and Adan, D. Perez Pflitsch, S. K. Pitzl, D. Raspereza, A. and Saibel, A. Savitskyi, M. Scheurer, V Schtze, P. and Schwanenberger, C. Shevchenko, R. Singh, A. Tholen, H. and Turkot, O. Vagnerini, A. Van De Klundert, M. Van Onsem, G. P. Walsh, R. Wen, Y. Wichmann, K. Wissing, C. and Zenaiev, O. Zlebcik, R. Aggleton, R. Bein, S. Benato, L. and Benecke, A. Blobel, V Dreyer, T. Ebrahimi, A. and Frhlich, A. Garbers, C. Garutti, E. Gonzalez, D. and Gunnellini, P. Haller, J. Hinzmann, A. Karavdina, A. and Kasieczka, G. Klanner, R. Kogler, R. Kovalchuk, N. Kurz, S. Kutzner, V Lange, J. Lange, T. Malara, A. and Multhaup, J. Niemeyer, C. E. N. Perieanu, A. Reimers, A. and Rieger, O. Scharf, C. Schleper, P. Schumann, S. and Schwandt, J. Sonneveld, J. Stadie, H. Steinbrueck, G. and Stober, F. M. Stoever, M. Vormwald, B. Zoi, I Akbiyik, M. Barth, C. Baselga, M. Baur, S. Berger, T. Butz, E. Caspart, R. Chwalek, T. De Boer, W. Dierlamm, A. and El Morabit, K. Faltermann, N. Giffels, M. Goldenzweig, P. and Gottmann, A. Harrendorf, M. A. Hartmann, F. Husemann, U. and Kudella, S. Mitra, S. Mozer, M. U. Mueller, Th and Musich, M. Nuernberg, A. Quast, G. Rabbertz, K. and Schroeder, M. Shvetsov, I Simonis, H. J. Ulrich, R. and Weber, M. Whrmann, C. Wolf, R. Anagnostou, G. Asenov, P. and Daskalakis, G. Geralis, T. Kyriakis, A. Loukas, D. and Paspalaki, G. Diamantopoulou, M. Karathanasis, G. and Kontaxakis, P. Manousakis-katsikakis, A. Panagiotou, A. and Papavergou, I Saoulidou, N. Stakia, A. Theofilatos, K. and Vellidis, K. Vourliotis, E. Bakas, G. Kousouris, K. and Papakrivopoulos, I Tsipolitis, G. Evangelou, I Foudas, C. and Gianneios, P. Katsoulis, P. Kokkas, P. Mallios, S. and Manitara, K. Manthos, N. Papadopoulos, I Strologas, J. and Triantis, F. A. Tsitsonis, D. Bartok, M. Csanad, M. and Major, P. Mandal, K. Mehta, A. Nagy, I, M. Pasztor, G. and Suranyi, O. Veres, I, G. Bencze, G. Hajdu, C. and Horvath, D. Sikler, F. Vami, T. A. Veszpremi, V. and Vesztergombi, G. Beni, N. Czellar, S. Karancsi, J. and Makovec, A. Molnar, J. Szillasi, Z. Raics, P. Teyssier, D. Trocsanyi, Z. L. Ujvari, B. Csorgo, T. Metzger, W. J. and Nemes, F. Novak, T. Choudhury, S. Komaragiri, J. R. and Tiwari, P. C. Bahinipati, S. Kar, C. Kole, G. Mal, P. and Bindhu, V. K. Muraleedharan Nair Nayak, A. Sahoo, D. K. and Swain, S. K. Bansal, S. Beri, S. B. Bhatnagar, V and Chauhan, S. Chawla, R. Dhingra, N. Gupta, R. Kaur, A. and Kaur, M. Kaur, S. Kumari, P. Lohan, M. Meena, M. and Sandeep, K. Sharma, S. Singh, J. B. Virdi, A. K. and Bhardwaj, A. Choudhary, B. C. Garg, R. B. Gola, M. and Keshri, S. AshokKumar Malhotra, S. Naimuddin, M. and Priyanka, P. Ranjan, K. AashaqShah Sharma, R. Bhardwaj, R. Bharti, M. Bhattacharya, R. Bhattacharya, S. and Bhawandeep, U. Bhowmik, D. Dey, S. Dutta, S. Maity, M. and Mondal, K. Nandan, S. Purohit, A. Rout, P. K. Saha, G. Sarkar, S. Sarkar, T. Sharan, M. Singh, B. and Thakur, S. Behera, P. K. Kalbhor, P. Muhammad, A. and Pujahari, P. R. Sikdar, A. K. Chudasama, R. Dutta, D. and Jha, V Kumar, V Mishra, D. K. Netrakanti, P. K. Pant, L. M. Shukla, P. Aziz, T. Bhat, M. A. Dugad, S. and Mohanty, G. B. Sur, N. KumarVerma, Ravindra Banerjee, S. and Chatterjee, S. Das, P. Guchait, M. Karmakar, S. Kumar, S. Majumder, G. Mazumdar, K. Sahoo, N. Sawant, S. and Dube, S. Hegde, V Kapoor, A. Kothekar, K. Pandey, S. and Rane, A. Rastogi, A. Chenarani, S. Tadavani, E. Eskandari and Etesami, S. M. Khakzad, M. Najafabadi, M. Mohammadi and Naseri, M. Hosseinabadi, F. Rezaei Felcini, M. Grunewald, M. and Abbrescia, M. Aly, R. Calabria, C. Colaleo, A. and Creanza, D. Cristella, L. De Filippis, N. De Palma, M. and Di Florio, A. Fiore, L. Gelmi, A. Iaselli, G. Ince, M. and Lezki, S. Maggi, G. Maggi, M. Miniello, G. My, S. and Nuzzo, S. Pompili, A. Pugliese, G. Radogna, R. and Ranieri, A. Selvaggi, G. Silvestris, L. Venditti, R. and Verwilligen, P. Abbiendi, G. Battilana, C. Bonacorsi, D. and Borgonovi, L. Braibant-Giacomelli, S. Campanini, R. and Capiluppi, P. Castro, A. Cavallo, F. R. Ciocca, C. and Codispoti, G. Cuffiani, M. Dallavalle, G. M. Fabbri, F. and Fanfani, A. Fontanesi, E. Giacomelli, P. Grandi, C. and Guiducci, L. Iemmi, F. Lo Meo, S. Marcellini, S. and Masetti, G. Navarria, F. L. Perrotta, A. Primavera, F. and Rossi, A. M. Rovelli, T. Siroli, G. P. Tosi, N. Albergo, S. Costa, S. Di Mattia, A. Potenza, R. Tricomi, A. and Tuve, C. Barbagli, G. Ceccarelli, R. Chatterjee, K. and Ciulli, V Civinini, C. D'Alessandro, R. Focardi, E. and Latino, G. Lenzi, P. Meschini, M. Paoletti, S. and Sguazzoni, G. Strom, D. Viliani, L. Benussi, L. Bianco, S. Piccolo, D. Bozzo, M. Ferro, F. Mulargia, R. and Robutti, E. Tosi, S. Benaglia, A. 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High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
A search for long-lived particles decaying to displaced, nonprompt jets and missing transverse momentum is presented. The data sample corresponds to an integrated luminosity of 137 fb(-1) of proton-proton collisions at a center-of-mass energy of 13 TeV collected by the CMS experiment at the CERN LHC in 2016-2018. Candidate signal events containing nonprompt jets are identified using the timing capabilities of the CMS electromagnetic calorimeter. The results of the search are consistent with the background prediction and are interpreted using a gauge-mediated supersymmetry breaking reference model with a gluino next-to-lightest supersymmetric particle. In this model, gluino masses up to 2100, 2500, and 1900 GeV are excluded at 95% confidence level for proper decay lengths of 0.3, 1, and 100 m, respectively. These are the best limits to date for such massive gluinos with proper decay lengths greater than similar to 0.5 m. (C) 2019 The Author. Published by Elsevier B.V.
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- 2019
185. Search for the production of (WWW -/+)-W-+/--W-+/- events at root s=13 TeV
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Elmer, P. and Hardenbrook, J. Haubrich, N. Higginbotham, S. and Kalogeropoulos, A. Kwan, S. Lange, D. Lucchini, M. T. and Luo, J. Marlow, D. Mei, K. Ojalvo, I. Olsen, J. and Palmer, C. Piroue, P. Salfeld-Nebgen, J. Stickland, D. and Tully, C. Wang, Z. Malik, S. Norberg, S. Barker, A. and Barnes, V. E. Das, S. Gutay, L. Jones, M. Jung, A. W. and Khatiwada, A. Mahakud, B. Miller, D. H. Negro, G. and Neumeister, N. Peng, C. C. Piperov, S. Qiu, H. Schulte, J. F. Sun, J. Wang, F. Xiao, R. Xie, W. Cheng, T. and Dolen, J. Parashar, N. Ecklund, K. M. Freed, S. and Geurts, F. J. M. Kilpatrick, M. Kumar, Arun Li, W. and Padley, B. P. Redjimi, R. Roberts, J. Rorie, J. Shi, W. and Leiton, A. G. Stahl Tu, Z. Zhang, A. Bodek, A. De Barbaro, P. Demina, R. Dulemba, J. L. Fallon, C. Ferbel, T. Galanti, M. Garcia-Bellido, A. Han, J. Hindrichs, O. and Khukhunaishvili, A. Ranken, E. Tan, P. Taus, R. and Chiarito, B. Chou, J. P. Gandrakota, A. Gershtein, Y. and Halkiadakis, E. Hart, A. Heindl, M. Hughes, E. Kaplan, S. Kyriacou, S. Laflotte, I. Lath, A. Montalvo, R. and Nash, K. Osherson, M. Saka, H. Salur, S. Schnetzer, S. and Sheffield, D. Somalwar, S. Stone, R. Thomas, S. and Thomassen, P. Acharya, H. Delannoy, A. G. Heideman, J. and Riley, G. Spanier, S. Vvv, O. Bouhali Celik, A. and Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. and Eusebi, R. Gilmore, J. Huang, T. Kamon, T. Luo, S. and Marley, D. Mueller, R. Overton, D. Pernie, L. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. De Guio, F. and Kunori, S. Lamichhane, K. Lee, S. W. Mengke, T. and Muthumuni, S. Peltola, T. Undleeb, S. Volobouev, I. and Wang, Z. Whitbeck, A. Greene, S. Gurrola, A. Janjam, R. and Johns, W. Maguire, C. Melo, A. Ni, H. Padeken, K. and Romeo, F. Sheldon, P. Tuo, S. Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. Cummings, G. and Hirosky, R. Joyce, M. Ledovskoy, A. Neu, C. Tannenwald, B. Wang, Y. Wolfe, E. Xia, F. Harr, R. Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. and Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. De Bruyn, I. Dodd, L. Fiori, F. Galloni, C. Gomber, B. and Herndon, M. Herve, A. Hussain, U. Klabbers, P. Lanaro, A. Loeliger, A. Long, K. Loveless, R. Sreekala, J. Madhusudanan Ruggles, T. Savin, A. Sharma, V. Smith, W. H. Teague, D. Trembath-Reichert, S. Woods, N. CMS Collaboration
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High Energy Physics::Experiment - Abstract
A search for the production of events containing three W bosons predicted by the standard model is reported. The search is based on a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the CMS experiment at the CERN LHC and corresponding to a total integrated luminosity of 35.9 fb(-1). The search is performed in final states with three leptons (electrons or muons), or with two same-charge leptons plus two jets. The observed (expected) significance of the signal for (WWW -/+)-W-+/--W-+/- production is 0.60 (1.78) standard deviations, and the ratio of the measured signal yield to that expected from the standard model is 0.34(-0.34)(+0.62) . Limits are placed on three anomalous quartic gauge couplings and on the production of massive axionlike particles.
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- 2019
186. Rich Azimuth Dual Triple-Source Simultaneous Shooting West of Shetland
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G. Poole, L. Saxton, G. James, R. Flower, T. Mensch, N. Benfield, E. Kaszycka, R. Wombell, C. Page, K. Cichy, D. Davies, S. Woods, and D. Dieulangard
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Shetland ,Regional geology ,Volcanism ,Gemology ,Economic geology ,Palaeogeography ,Geology ,Seismology ,Environmental geology ,Geobiology - Abstract
Summary We discuss the survey planning and provide results from a marine acquisition conducted northwest of the Shetland Islands. The survey was designed to image multiple targets from shallow Tertiary and Cretaceous plays, through to complex fractured Devono-Carboniferous reservoirs. Marine acquisitions are typically conducted along the direction of structural dip. In this case, this was not possible due to the proximity of the survey to the Shetland Islands. In an attempt to address this problem, triple sources were deployed to decrease the spacing between inlines and improve sampling along the structural dip direction. In addition, a second vessel was deployed broadside in a rich-azimuth configuration to increase offset coverage in the y-direction and to help undershoot sills and dykes present in the area. Activating so many sources sequentially would significantly decrease fold and increase noise levels of the data. After careful scenario testing and de-risking, which involved blending and deblending conventional data in various ways, the decision was made to acquire the data with simultaneous shooting. Data after deblending and depth imaging highlight the benefits provided by this rich-azimuth approach.
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- 2019
187. Search for Higgs and Z boson decays to J/psi or Y pairs in the four-muon final state in proton-proton collisions at root s=13 TeV
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Sirunyan, A. M. Tumasyan, A. Adam, W. Ambrogi, F. and Bergauer, T. Brandstetter, J. Dragicevic, M. Eroe, J. and Del Valle, A. Escalante Flechl, M. Fruehwirth, R. Jeitler, M. Krammer, N. Kraetschmer, I Liko, D. Madlener, T. and Mikulec, I Rad, N. Schieck, J. Schoefbeck, R. Spanring, M. Spitzbart, D. Waltenberger, W. Wulz, C-E Zarucki, M. and Drugakov, V Mossolov, V Gonzalez, J. Suarez Darwish, M. R. De Wolf, E. A. Di Croce, D. Janssen, X. Lauwers, J. and Lelek, A. Pieters, M. Sfar, H. Rejeb Van Haevermaet, H. and Van Mechelen, P. Van Putte, S. Van Remortel, N. Blekman, F. Bols, E. S. Chhibra, S. S. D'Hondt, J. De Clercq, J. and Lontkovskyi, D. Lowette, S. Marchesini, I Moortgat, S. and Moreels, L. Python, Q. Skovpen, K. Tavernier, S. Van Doninck, W. Van Mulders, P. Van Parijs, I Beghin, D. and Bilin, B. Brun, H. Clerbaux, B. De Lentdecker, G. and Delannoy, H. Dorney, B. Favart, L. Grebenyuk, A. Kalsi, A. K. Luetic, J. Popov, A. Postiau, N. Starling, E. and Thomas, L. Vander Velde, C. Vanlaer, P. Vannerom, D. and Wang, Q. Cornelis, T. Dobur, D. Khvastunov, I Roskas, C. and Trocino, D. Tytgat, M. Verbeke, W. Vermassen, B. and Vit, M. Zaganidis, N. Bondu, O. Bruno, G. Caputo, C. and David, P. Delaere, C. Delcourt, M. Giammanco, A. and Lemaitre, V Magitteri, A. Prisciandaro, J. Saggio, A. and Marono, M. Vidal Vischia, P. Zobec, J. Alves, F. L. and Alves, G. A. Correia Silva, G. Hensel, C. Moraes, A. and Rebello Teles, P. Belchior Batista Das Chagas, E. Carvalho, W. and Chinellato, J. Coelho, E. Da Costa, E. M. Da Silveira, G. G. De Jesus Damiao, D. De Oliveira Martins, C. Fonseca De Souza, S. Huertas Guativa, L. M. Malbouisson, H. Martins, J. and Matos Figueiredo, D. Medina Jaime, M. Melo De Almeida, M. and Mora Herrera, C. Mundim, L. Nogima, H. Prado Da Silva, W. L. Sanchez Rosas, L. J. Santoro, A. Sznajder, A. and Thiel, M. Tonelli Manganote, E. J. Torres Da Silva De Araujo, F. and Vilela Pereira, A. Ahuja, S. Bernardes, C. A. and Calligaris, L. 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Dildick, S. Eusebi, R. and Gilmore, J. Huang, T. Kamon, T. Luo, S. Marley, D. and Mueller, R. Overton, D. Pernie, L. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. De Guio, F. Kunori, S. and Lamichhane, K. Mengke, T. Muthumuni, S. Peltola, T. and Undleeb, S. Volobouev, I Whitbeck, A. Greene, S. and Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. and Ni, H. Padeken, K. Romeo, F. Sheldon, P. Tuo, S. and Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. Cummings, G. Hirosky, R. Joyce, M. Ledovskoy, A. and Neu, C. Tannenwald, B. Wolfe, E. Xia, F. Harr, R. and Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. and De Bruyn, I Dodd, L. Fiori, F. Galloni, C. Gomber, B. and Herndon, M. Herve, A. Hussain, U. Klabbers, P. and Lanaro, A. Loeliger, A. Long, K. Loveless, R. Sreekala, J. Madhusudanan Ruggles, T. Savin, A. Smith, W. H. and Teague, D. Trembath-Reichert, S. Woods, N. CMS Collaboration
- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
A search for decays of the Higgs and Z boson to pairs of J/psi or Y(nS)(n = 1, 2, 3) mesons, with their subsequent decay to mu(+)mu(-) pairs, is presented. The analysis uses data from proton-proton collisions at root s = 13 TeV, collected with the CMS detector at the LHC in 2017 and corresponding to an integrated luminosity of 37.5 fb(-1). While an observation of such a decay with this sample would indicate the presence of physics beyond the standard model, no significant excess is observed. Upper limits at 95% confidence level are placed on the branching fractions of these decays. In the J/psi pair channel, the limits are 1.8 x 10(-3) and 2.2 x 10(-6) for the Higgs and Z boson, respectively, while in the combined Y(nS) pair channel, the limits are 1.4 x 10(-3) and 1.5 x 10(-6), respectively, when the mesons from the Higgs and Z boson decay are assumed to be unpolarized. When fully longitudinal and transverse polarizations are considered the limits reduce by about 22-29% and increase by about 10-13%, respectively. (C) 2019 The Author(s). Published by Elsevier B.V.
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- 2019
188. Hydrogen Safety
- Author
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Stephen S. Woods
- Published
- 2019
189. Search for Physics beyond the Standard Model in Events with Overlapping Photons and Jets
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Huang, T. and Kamon, T. Luo, S. Marley, D. Mueller, R. Overton, D. and Pernie, L. Rathjens, D. Safonov, A. Akchurin, N. and Damgov, J. De Guio, F. Kunori, S. Lamichhane, K. Mengke, T. Muthumuni, S. Peltola, T. Undleeb, S. Volobouev, I and Whitbeck, A. Greene, S. Gurrola, A. Janjam, R. and Johns, W. Maguire, C. Melo, A. Ni, H. Padeken, K. and Romeo, F. Sheldon, P. Tuo, S. Velkovska, J. Verweij, M. and Arenton, M. W. Barria, P. Cox, B. Cummings, G. and Hirosky, R. Joyce, M. Ledovskoy, A. Neu, C. Tannenwald, B. Wolfe, E. Xia, F. Harr, R. Karchin, P. E. and Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. De Bruyn, I and Dodd, L. Fiori, F. Galloni, C. Gomber, B. Herndon, M. and Herve, A. Hussain, U. Klabbers, P. Lanaro, A. and Loeliger, A. Long, K. Loveless, R. Sreekala, J. Madhusudanan and Ruggles, T. Savin, A. Smith, W. H. Teague, D. and Trembath-reichert, S. Woods, N. CMS Collaboration
- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
Results are reported from a search for new particles that decay into a photon and two gluons, in events with jets. Novel jet substructure techniques are developed that allow photons to be identified in an environment densely populated with hadrons. The analyzed proton-proton collision data were collected by the CMS experiment at the LHC, in 2016 at root s = 13 TeV, and correspond to an integrated luminosity of 35.9 fb(-1). The spectra of total transverse hadronic energy of candidate events are examined for deviations from the standard model predictions. No statistically significant excess is observed over the expected background. The first cross section limits on new physics processes resulting in such events are set. The results are interpreted as upper limits on the rate of gluino pair production, utilizing a simplified stealth supersymmetry model. The excluded gluino masses extend up to 1.7 TeV, for a neutralino mass of 200 GeV and exceed previous mass constraints set by analyses targeting events with isolated photons.
- Published
- 2019
190. Search for low mass vector resonances decaying into quark-antiquark pairs in proton-proton collisions at √s=13 TeV
- Author
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- Subjects
High Energy Physics::Experiment - Abstract
A search for low mass narrow vector resonances decaying into quark-antiquark pairs is presented. The analysis is based on data collected in 2017 with the CMS detector at the LHC in proton-proton collisions at a center-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 41.1 fb-1. The results of this analysis are combined with those of an earlier analysis based on data collected at the same collision energy in 2016, corresponding to 35.9 fb-1. Signal candidates will be recoiling against initial state radiation and are identified as energetic, large-radius jets with two pronged substructure. The invariant jet mass spectrum is probed for a potential narrow peaking signal over a smoothly falling background. No evidence for such resonances is observed within the mass range of 50-450 GeV. Upper limits at the 95%confidence level are set on the coupling of narrow resonances to quarks, as a function of the resonance mass. For masses between 50 and 300 GeV these are the most sensitive limits to date. This analysis extends the earlier search to a mass range of 300-450 GeV, which is probed for the first time with jet substructure techniques. © 2019 CERN, for the CMS Collaboration.
- Published
- 2019
191. Search for pair production of vectorlike quarks in the fully hadronic final state
- Author
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- Subjects
High Energy Physics::Phenomenology ,High Energy Physics::Experiment - Abstract
The results of two searches for pair production of vectorlike T or B quarks in fully hadronic final states are presented, using data from the CMS experiment at a center-of-mass energy of 13 TeV. The data were collected at the LHC during 2016 and correspond to an integrated luminosity of 35.9 fb(-1). A cut-based analysis specifically targets the bW decay mode of the T quark and allows for the reconstruction of the T quark candidates. In a second analysis, a multiclassification algorithm, the “boosted event shape tagger,” is deployed to label candidate jets as originating from top quarks, and W, Z, and H. Candidate events are categorized according to the multiplicities of identified jets, and the scalar sum of all observed jet momenta is used to discriminate signal events from the quantum chromodynamics multijet background. Both analyses probe all possible branching fraction combinations of the T and B quarks and set limits at 95% confidence level on their masses, ranging from 740 to 1370 GeV. These results represent a significant improvement relative to existing searches in the fully hadronic final state.
- Published
- 2019
192. Study of the B+ -> J/psi(Lambda)over-barp decay in proton-proton collisions at root s=8 TeV
- Author
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Strobbe, N. Taylor, L. Tkaczyk, S. Tran, V, N. Uplegger, L. Vaandering, E. W. Vernieri, C. and Verzocchi, M. Vidal, R. Wang, M. Weber, H. A. Acosta, D. and Avery, P. Bourilkov, D. Brinkerhoff, A. Cadamuro, L. and Carnes, A. Cherepanov, V Curry, D. Errico, F. Field, R. D. Gleyzer, V, S. Joshi, B. M. Kim, M. Konigsberg, J. and Korytov, A. Lo, K. H. Ma, P. Matchev, K. Menendez, N. Mitselmakher, G. Rosenzweig, D. Shi, K. Wang, J. and Zuo, X. Joshi, Y. R. Adams, T. Askew, A. Hagopian, S. and Hagopian, V Johnson, K. F. Khurana, R. Kolberg, T. and Martinez, G. Perry, T. Prosper, H. Schiber, C. Yohay, R. and Zhang, J. Baarmand, M. M. Bhopatkar, V Hohlmann, M. and Noonan, D. Rahmani, M. Saunders, M. Yumiceva, F. Adams, M. R. Apanasevich, L. Berry, D. Betts, R. R. Cavanaugh, R. Chen, X. Dittmer, S. Evdokimov, O. Gerber, C. E. and Hangal, D. A. Hofman, D. J. Jung, K. Mills, C. Roy, T. and Tonjes, M. B. Varelas, N. Wang, H. Wang, X. Wu, Z. and Alhusseini, M. Bilki, B. Clarida, W. Dilsiz, K. and Durgut, S. Gandrajula, R. P. Haytmyradov, M. Khristenko, V and Koseyan, O. K. Merlo, J-P Mestvirishvili, A. Moeller, A. and Nachtman, J. Ogul, H. Onel, Y. Ozok, F. Penzo, A. and Snyder, C. Tiras, E. Wetzel, J. Blumenfeld, B. and Cocoros, A. Eminizer, N. Fehling, D. Feng, L. Gritsan, V, A. Hung, W. T. Maksimovic, P. Roskes, J. Swartz, M. and Xiao, M. Barrera, C. Baldenegro Baringer, P. Bean, A. and Boren, S. Bowen, J. Bylinkin, A. Isidori, T. Khalil, S. King, J. Krintiras, G. Kropivnitskaya, A. Lindsey, C. and Majumder, D. Mcbrayer, W. Minafra, N. Murray, M. and Rogan, C. Royon, C. Sanders, S. Schmitz, E. Takaki, J. D. Tapia Williams, J. Wilson, G. Duric, S. Ivanov, A. and Kaadze, K. Kim, D. Maravin, Y. Mendis, D. R. and Mitchell, T. Modak, A. Mohammadi, A. Rebassoo, F. and Wright, D. Baden, A. Baron, O. Belloni, A. Eno, S. C. and Feng, Y. Hadley, N. J. Jabeen, S. Jeng, G. Y. and Kellogg, R. G. Kunkle, J. Mignerey, A. C. Nabili, S. and Ricci-Tam, F. Seidel, M. Shin, Y. H. Skuja, A. Tonwar, S. C. Wong, K. Abercrombie, D. Allen, B. Baty, A. and Bi, R. Brandt, S. Busza, W. Cali, I. A. D'Alfonso, M. and Ceballos, G. Gomez Goncharov, M. Harris, P. Hsu, D. and Hu, M. Klute, M. Kovalskyi, D. Lee, Y-J Luckey, P. D. and Maier, B. Marini, A. C. Mcginn, C. Mironov, C. and Narayanan, S. Niu, X. Paus, C. Rankin, D. Roland, C. and Roland, G. Shi, Z. Stephans, G. S. F. Sumorok, K. Tatar, K. Velicanu, D. Wang, T. W. Wyslouch, B. Benvenuti, A. C. Chatterjee, R. M. Evans, A. Guts, S. Hansen, P. and Hiltbrand, J. Jain, Sh Kalafut, S. Kubota, Y. Lesko, Z. and Mans, J. Rusack, R. Wadud, M. A. Acosta, J. G. and Oliveros, S. Bloom, K. Claes, D. R. Fangmeier, C. Finco, L. Golf, F. Suarez, R. Gonzalez Kamalieddin, R. and Kravchenko, I Siado, J. E. Snow, G. R. Stieger, B. and Agarwal, G. Harrington, C. Iashvili, I. Kharchilava, A. and Mclean, C. Nguyen, D. Parker, A. Pekkanen, J. Rappoccio, S. Roozbahani, B. Alverson, G. Barberis, E. Freer, C. and Haddad, Y. Hortiangtham, A. Madigan, G. Morse, D. M. and Orimoto, T. Skinnari, L. Tishelman-Charny, A. Wamorkar, T. and Wang, B. Wisecarver, A. Wood, D. Bueghly, J. Gunter, T. Hahn, K. A. Odell, N. Schmitt, M. H. Sung, K. and Trovato, M. Velasco, M. Bucci, R. Dev, N. Goldouzian, R. and Hildreth, M. Anampa, K. Hurtado Jessop, C. Karmgard, D. J. Lannon, K. Li, W. Loukas, N. Marinelli, N. and Mcalister, I Meng, F. Mueller, C. Musienko, Y. Planer, M. Ruchti, R. Siddireddy, P. Smith, G. Taroni, S. and Wayne, M. Wightman, A. Wolf, M. Woodard, A. Alimena, J. and Bylsma, B. Durkin, L. S. Flowers, S. Francis, B. and Hill, C. Ji, W. Lefeld, A. Ling, T. Y. Winer, B. L. and Cooperstein, S. Dezoort, G. Elmer, P. Hardenbrook, J. and Haubrich, N. Higginbotham, S. Kalogeropoulos, A. Kwan, S. and Lange, D. Lucchini, M. T. Luo, J. Marlow, D. Mei, K. and Ojalvo, I Olsen, J. Palmer, C. Piroue, P. and Salfeld-Nebgen, J. Stickland, D. Tully, C. Norberg, S. and Barker, A. Barnes, V. E. Gutay, L. Jones, M. Jung, A. W. and Khatiwada, A. Mahakud, B. Miller, D. H. Negro, G. and Neumeister, N. Peng, C. C. Piperov, S. Qiu, H. Schulte, J. F. Sun, J. Wang, F. Xiao, R. Xie, W. Cheng, T. and Dolen, J. Parashar, N. Ecklund, K. M. Freed, S. and Geurts, F. J. M. Kilpatrick, M. Kumar, Arun Padley, B. P. and Redjimi, R. Roberts, J. Rorie, J. Shi, W. Leiton, A. G. Stahl Tu, Z. Zhang, A. Bodek, A. de Barbaro, P. and Demina, R. Dulemba, J. L. Fallon, C. Ferbel, T. Galanti, M. Garcia-Bellido, A. Han, J. Hindrichs, O. and Khukhunaishvili, A. Ranken, E. Tan, P. Taus, R. and Chiarito, B. Chou, J. P. Gandrakota, A. Gershtein, Y. and Halkiadakis, E. Hart, A. Heindl, M. Hughes, E. Kaplan, S. Kyriacou, S. Laflotte, I Lath, A. Montalvo, R. and Nash, K. Osherson, M. Saka, H. Salur, S. Schnetzer, S. and Sheffield, D. Somalwar, S. Stone, R. Thomas, S. and Thomassen, P. Acharya, H. Delannoy, A. G. Heideman, J. and Riley, G. Spanier, S. Bouhali, O. Celik, A. Dalchenko, M. De Mattia, M. Delgado, A. Dildick, S. Eusebi, R. and Gilmore, J. Huang, T. Kamon, T. Luo, S. Marley, D. and Mueller, R. Overton, D. Pernie, L. Rathjens, D. Safonov, A. Akchurin, N. Damgov, J. De Guio, F. Kunori, S. and Lamichhane, K. Mengke, T. Muthumuni, S. Peltola, T. and Undleeb, S. Volobouev, I Whitbeck, A. Greene, S. and Gurrola, A. Janjam, R. Johns, W. Maguire, C. Melo, A. and Ni, H. Padeken, K. Romeo, F. Sheldon, P. Tuo, S. and Velkovska, J. Verweij, M. Arenton, M. W. Barria, P. Cox, B. Cummings, G. Hirosky, R. Joyce, M. Ledovskoy, A. and Neu, C. Tannenwald, B. Wolfe, E. Xia, F. Harr, R. and Karchin, P. E. Poudyal, N. Sturdy, J. Thapa, P. Zaleski, S. Buchanan, J. Caillol, C. Carlsmith, D. Dasu, S. and De Bruyn, I Dodd, L. Fiori, F. Galloni, C. Gomber, B. and He, H. Herndon, M. Herve, A. Hussain, U. Klabbers, P. Lanaro, A. Loeliger, A. Long, K. Loveless, R. and Sreekala, J. Madhusudanan Ruggles, T. Savin, A. Smith, W. H. and Teague, D. Trembath-reichert, S. Woods, N. CMS Collaboration
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High Energy Physics::Experiment - Abstract
A study of the B+-> J/psi = 8 TeV by the CMS experiment at the LHC, corresponding to an integrated luminosity of 19.6 fb(-1), is presented. The ratio of branching fractions B+-> J/psi B+-> J/psi K is measured to be (1.054 +/- 0.057(stat) +/- 0.035(syst) +/- 0.011 where the last uncertainty reflects the uncertainties in the world-average branching fractions of and K*(892) (+) decays to reconstructed final states. The invariant mass distributions of the J/psi, J/psi systems produced in the B+-> J/psi decay are investigated and found to be inconsistent with the pure phase space hypothesis. The analysis is extended by using a model-independent angular amplitude analysis, which shows that the observed invariant mass distributions are consistent with the contributions from excited kaons decaying to the (Lambda) over barp system.
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- 2019
193. Necrotizing Myositis: A Rare Necrotizing Soft Tissue Infection Involving Muscle
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Harika, Boinpally, Raelina S, Howell, Bebu, Ram, Virginia, Donovan, Michael, Castellano, John S, Woods, and Scott, Gorenstein
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Male ,Hyperbaric Oxygenation ,Myositis ,Soft Tissue Infections ,Prostatic Neoplasms ,Pubic Symphysis ,Treatment Outcome ,Thigh ,Streptococcal Infections ,Clostridium Infections ,Humans ,Fasciitis, Necrotizing ,Muscle, Skeletal ,Radiation Injuries ,Tomography, X-Ray Computed ,Negative-Pressure Wound Therapy ,Aged - Abstract
Necrotizing myositis (NM) is an extremely rare necrotizing soft tissue infection involving muscle. Unlike similar infections (eg, necrotizing fasciitis, clostridial myonecrosis) that can be more readily diagnosed, NM can have a benign presentation then rapidly progress into a life-threatening condition with a mortality rate of 100% without surgical intervention.A 74-year-old man with a history of prostate cancer with radiation therapy, seed implants, and 2 transurethral resection procedures presented to the emergency department after a fall. He was initially diagnosed and treated for urosepsis. Sixteen hours after presentation, he complained of pain and swelling of his right groin. Computed tomography of the abdomen and pelvis showed gas findings suspicious for necrotizing infection of the bilateral thighs. Surgical exploration revealed NM. Separate cultures from the left thigh and bladder grew Streptococcus intermedius, Clostridium clostridioforme, and Peptostreptococcus, suggesting a possible common source of infection from the prostate gland or the osteomyelitic pubic symphysis, which subsequently spread to the bilateral thighs.To the best of the authors' knowledge, this is the first reported case of S intermedius and C clostridioforme causing NM. A high index of suspicion is required for extremely rare conditions like NM, because early diagnosis and surgical intervention significantly reduce mortality.
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- 2018
194. Feeding dihydroquercetin to broiler chickens
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Mehmet Reşit Karageçili, S. Woods, S C Mansbridge, Stephen Paul Rose, C Westbrook, Filiz Karadas, and Vasil Pirgozliev
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Gastrointestinal tract ,040301 veterinary sciences ,animal diseases ,0402 animal and dairy science ,Broiler ,04 agricultural and veterinary sciences ,General Medicine ,Biology ,040201 dairy & animal science ,0403 veterinary science ,Immune system ,parasitic diseases ,Animal Science and Zoology ,Food science ,Food Science - Abstract
1. A total of 80 male Ross 308 broilers were used in a study to investigate the effect of dietary dihydroquercetin (DHQ) on growth performance variables, gastrointestinal tract (GIT) and immune organ development, glutathione peroxidase (GPx) and haemoglobin in blood, hepatic vitamin E content, dietary N-corrected metabolisable energy (AMEn) and nutrient retention coefficients when fed to broiler chickens from 7 to 35 d of age. 2. Two treatments were used in this study: control (C) and C + 0.5 g/kg extract of Siberian Larch (Larix sibirica) per kg feed, containing 85% DHQ. The diets were fed over 2 feeding phases, a grower phase from 7 to 28 d of age and a finisher phase from 28 to 35 d of age. The birds were reared under the breeder's recommended conditions. 3. In general, there were no effects of DHQ on growth performance of broiler chickens. However, the results of this experiment showed that there can be changes in the redness colour of the breast meat when DQH is fed. No negative effects of feeding DHQ at 0.5 g/kg diet were observed in this study. 4. Supplementation of poultry diets with DHQ under standard industry-rearing conditions did not improve the performance or any of the studied variables, except an increase of redness index of the breast fillets. Feeding DHQ at different doses and/or under more challenging conditions, e.g. heat stress, may, however, bring positive responses.
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- 2018
195. Hypothesis testing clarifies the systematics of the main Central American Chagas disease vector, Triatoma dimidiata (Latreille, 1811), across its geographic range
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Adrienne S. Woods, Nicholas M. de la Rúa, Lori Stevens, C. William Kilpatrick, Nicholas Smith, Patricia L. Dorn, Julianne Suarez, Jirias Charabati, Bethany Richards, Rafaela Pessoa, Carlota Monroy, and Heather J. Axen
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0301 basic medicine ,Microbiology (medical) ,Systematics ,Species complex ,Trypanosoma cruzi ,030231 tropical medicine ,Zoology ,Subspecies ,Microbiology ,Article ,03 medical and health sciences ,Monophyly ,0302 clinical medicine ,DNA, Ribosomal Spacer ,parasitic diseases ,Genetics ,Animals ,Humans ,Chagas Disease ,Triatoma ,Triatoma dimidiata ,Internal transcribed spacer ,Molecular Biology ,Phylogeny ,Ecology, Evolution, Behavior and Systematics ,biology ,Phylogenetic tree ,Cytochrome b ,Central America ,Cytochromes b ,biology.organism_classification ,Insect Vectors ,Phylogeography ,Genes, Mitochondrial ,030104 developmental biology ,Infectious Diseases ,Haplotypes - Abstract
The widespread and diverse Triatoma dimidiata is the kissing bug species most important for Chagas disease transmission in Central America and a secondary vector in Mexico and northern South America. Its diversity may contribute to different Chagas disease prevalence in different localities and has led to conflicting systematic hypotheses describing various populations as subspecies or cryptic species. To resolve these conflicting hypotheses, we sequenced a nuclear (internal transcribed spacer 2, ITS-2) and mitochondrial gene (cytochrome b) from an extensive sampling of T. dimidiata across its geographic range. We evaluated the congruence of ITS-2 and cyt b phylogenies and tested the support for the previously proposed subspecies (inferred from ITS-2) by: (1) overlaying the ITS-2 subspecies assignments on a cyt b tree and, (2) assessing the statistical support for a cyt b topology constrained by the subspecies hypothesis. Unconstrained phylogenies inferred from ITS-2 and cyt b are congruent and reveal three clades including two putative cryptic species in addition to T. dimidiata sensu stricto. Neither the cyt b phylogeny nor hypothesis testing support the proposed subspecies inferred from ITS-2. Additionally, the two cryptic species are supported by phylogenies inferred from mitochondrially-encoded genes cytochrome c oxidase I and NADH dehydrogenase 4. In summary, our results reveal two cryptic species. Phylogenetic relationships indicate T. dimidiata sensu stricto is not subdivided into monophyletic clades consistent with subspecies. Based on increased support by hypothesis testing, we propose an updated systematic hypothesis for T. dimidiata based on extensive taxon sampling and analysis of both mitochondrial and nuclear genes.
- Published
- 2016
196. Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury
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Damon C. Barbacci, Amina S. Woods, Carey D. Balaban, Barry Hoffer, Aurelie Roux, J. Albert Schultz, Shawn Gouty, Jeremy Post, Shelley N. Jackson, Kathrine Baldwin, Ludovic Muller, and Brian M. Cox
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Male ,0301 basic medicine ,Cell signaling ,Pathology ,medicine.medical_specialty ,Time Factors ,Traumatic brain injury ,Membrane lipids ,Metal Nanoparticles ,Mass Spectrometry ,Article ,Mass spectrometry imaging ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,Fiducial Markers ,Brain Injuries, Traumatic ,Concussion ,Animals ,Medicine ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,Brain ,Silver Compounds ,medicine.disease ,Lipids ,Sphingolipid ,Disease Models, Animal ,030104 developmental biology ,Disease Progression ,Sphingomyelin ,business ,Lipid profile ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Background Mild traumatic brain injury (TBI) is a common public health issue that may contribute to chronic degenerative disorders. Membrane lipids play a key role in tissue responses to injury, both as cell signals and as components of membrane structure and cell signaling. This study demonstrates the ability of high resolution mass spectrometry imaging (MSI) to assess sequences of responses of lipid species in a rat controlled cortical impact model for concussion. New method A matrix of implanted silver nanoparticles was implanted superficially in brain sections for matrix-assisted laser desorption (MALDI) imaging of 50 μm diameter microdomains across unfixed cryostat sections of rat brain. Ion-mobility time-of-flight MS was used to analyze and map changes over time in brain lipid composition in a rats after Controlled Cortical Impact (CCI) TBI. Results Brain MS images showed changes in sphingolipids near the CCI site, including increased ceramides and decreased sphingomyelins, accompanied by changes in glycerophospholipids and cholesterol derivatives. The kinetics differed for each lipid class; for example ceramides increased as early as 1 day after the injury whereas other lipids changes occurred between 3 and 7 days post injury. Comparison with existing method(s) Silver nanoparticles MALDI matrix is a sensitive new tool for revealing previously undetectable cellular injury response and remodeling in neural, glial and vascular structure of the brain. Conclusions Lipid biochemical and structural changes after TBI could help highlighting molecules that can be used to determine the severity of such injuries as well as to evaluate the efficacy of potential treatments.
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- 2016
197. Victims and Patriots: Disaggregating Nationalism in Urban China
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Jackson S. Woods and Bruce J. Dickson
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business.industry ,Urban china ,media_common.quotation_subject ,05 social sciences ,Geography, Planning and Development ,050801 communication & media studies ,Gender studies ,Development ,Public opinion ,0506 political science ,Nationalism ,0508 media and communications ,Types of nationalism ,Political economy ,Political Science and International Relations ,Patriotism ,050602 political science & public administration ,Sociology ,business ,China ,Cultural production and nationalism ,media_common - Abstract
By most accounts, nationalism in China is on the rise, as seen in both patriotic displays and anti-foreign protests. This article disaggregates two types of nationalism: patriotism and victimization derived from the ‘century of humiliations’. An original, nationwide public opinion survey of urban China shows that these two types of nationalism are derived from similar attributes and attitudes (causes) but have dissimilar impacts on views toward foreign countries (effects). In order to understand properly the causes of rising nationalism in China and its possible implications, observers must begin with the recognition that patriotism and anti-foreign sentiments are not simply two sides of the same coin, but two separate and distinct types of nationalism.
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- 2016
198. Ethanol Induced Brain Lipid Changes in Mice Assessed by Mass Spectrometry
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Nora D. Volkow, Aurelie Roux, Joseph R. O’Rourke, Panayotis K. Thanos, J. Albert Schultz, Shelley N. Jackson, Damon C. Barbacci, Amina S. Woods, Ludovic Muller, and Carey D. Balaban
- Subjects
Male ,0301 basic medicine ,medicine.medical_specialty ,Physiology ,Cognitive Neuroscience ,Cell ,Alcohol ,Glycerophospholipids ,Mass spectrometry ,Biochemistry ,Article ,Mass Spectrometry ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Ethanol ,Age Factors ,Brain ,Central Nervous System Depressants ,Lipid metabolism ,Cell Biology ,General Medicine ,Lipid Metabolism ,Lipids ,Sphingolipid ,Mice, Inbred C57BL ,030104 developmental biology ,medicine.anatomical_structure ,Endocrinology ,chemistry ,Signal transduction ,030217 neurology & neurosurgery - Abstract
Alcohol abuse is a chronic disease characterized by the consumption of alcohol at a level that interferes with physical and mental health and causes serious and persistent changes in the brain. Lipid metabolism is of particular interest due to its high concentration in the brain. Lipids are the main component of cell membranes, are involved in cell signaling, signal transduction, and energy storage. In this study, we analyzed lipid composition of chronically ethanol exposed mouse brains. Juvenile (JUV) and adult (ADU) mice were placed on a daily limited-access ethanol intake model for 52 days. After euthanasia, brains were harvested, and total lipids were extracted from brain homogenates. Samples were analyzed using high resolution mass spectrometry and processed by multivariate and univariate statistical analysis. Significant lipid changes were observed in different classes including sphingolipids, fatty acids, lysophosphatidylcholines, and other glycerophospholipids.
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- 2016
199. Abstracts from the BJA Research Forum
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Azeem Alam, M. Charlton, L. Gardner, Jeanne Moriarty, R. J. Anthony, H. Galley, A. Glass, Donald H. Burke, D. Fiszer, L. Jolly, C. Schofield, T. Elajnef, S. Woods, Lingzhi Wu, Helen Laycock, Jane Quinlan, Ben Shelley, A. Koelewyn, S. Maslekar, Sarah Ciechanowicz, I. Umar, John Kinsella, C. Pocknall, Tim G. Hales, T. Dale Maclaine, P. McCall, R. Russell, Hailin Zhao, Catherine E. Warnaby, C. Schultz-Swarthfigure, R. Docking, Mark Wilson, Simon J. Howell, Marie-Anne Shaw, Emer Guinan, Helen F. Galley, N. Beale, Mel McKendrick, A. Chandra, Xiaochun Liao, S. Bowrey, T. Tafili, D. Roiz de Sa, P. Sonecki, C. Hebbes, Fiona Wilson, L. Buck, Daqing Ma, John F. Thompson, Jiang Cui, M. Columb, Michael C. Lee, P. Halford, Mateo Obregón, Masao Takata, Jonathan Moran, P. Raju, C. Daly, A. Windle, Paul McCormick, J. Marinkovic, George Corner, Z. Milan, G. Devoy, D. Fido, D.E. Kean, Carsten Bantel, S. J. Howell, Philip M. Hopkins, Marcela P. Vizcaychipi, N. Flint, Daniel T. Baptista-Hon, Alan Kirk, Z. Huang, B. McCormick, Juliette Hussey, M. Shaw, Graeme McLeod, S. Ong, and O. Kciuk
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03 medical and health sciences ,0302 clinical medicine ,Anesthesiology and Pain Medicine ,030202 anesthesiology ,business.industry ,Library science ,Medicine ,030204 cardiovascular system & hematology ,business - Published
- 2016
200. Student–Mentor Relationships and Students' College Attitudes
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Chenoa S. Woods and Mariana Preciado
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Academic preparation ,Medical education ,business.industry ,05 social sciences ,Multilevel model ,050301 education ,Diagnostic test ,Education ,0502 economics and business ,ComputingMilieux_COMPUTERSANDEDUCATION ,Survey data collection ,Medicine ,050207 economics ,business ,Baseline (configuration management) ,0503 education - Abstract
Many college and SAT preparation programs are designed to improve the postsecondary success of traditionally marginalized students. In addition to academic preparation, students' social and emotional preparation is important for the transition from high school to college. Mentors can serve as role models and supports to aid students in this development. Using student survey data and hierarchical linear modeling, this study examines the influences of student–mentor relationships within an SAT program setting on students' college attitudes. Results indicate that these relationships can positively influence students' college attitudes, particularly for students who have lower baseline SAT scores. Recommendations for future research and practice are provided.
- Published
- 2016
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