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1,041 results on '"Rupprecht R"'

152. Editorial

Author

Hegerl, U, primary, Himmerich, H, additional, and Rupprecht, R, additional

Published
2011
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158. Roboter zur Demontage

Author

Kahmeyer, M., Rupprecht, R., and Publica

Subjects
Demontage, Fahrzeugdemontage, Industrieroboter, Automobilindustrie
Abstract

In den Werkhallen der Automobilindustrie sind Industrieroboter unverzichtbare Produktionshelfer. Nach den Vorstellungen des IPA sollen sie nun auch die Fahrzeugdemontage wirtschaftlich machen.

Published
1994

164. A genome-wide association study points to multiple loci predicting antidepressant treatment outcome in depression

Author

Ising, M, primary, Lucae, S, additional, Binder, EB, additional, Bettecken, T, additional, Uhr, M, additional, Ripke, S, additional, Kohli, MA, additional, Hennings, JM, additional, Horstmann, S, additional, Kloiber, S, additional, Menke, A, additional, Bondy, B, additional, Rupprecht, R, additional, Domschke, K, additional, Baune, BT, additional, Arolt, V, additional, Rush, AJ, additional, Holsboer, F, additional, and Müller-Myhsok, B, additional

Published
2009
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165. Editorial

Author

Hiemke, C, primary, Schlösser, B, additional, and Rupprecht, R, additional

Published
2009
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169. Depressive Kernsymptome

Author

Damm, J., primary, Eser, D., additional, Schüle, C., additional, Möller, H.-J., additional, Rupprecht, R., additional, and Baghai, T.C., additional

Published
2009
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173. Independent Component Analysis Applied to Pharmacological Magnetic Resonance Imaging (phMRI): New Insights Into the Functional Networks Underlying Panic Attacks as Induced by CCK-4

Author

Dieler, A., primary, Samann, P., additional, Leicht, G., additional, Eser, D., additional, Kirsch, V., additional, Baghai, T., additional, Karch, S., additional, Schule, C., additional, Pogarell, O., additional, Czisch, M., additional, Rupprecht, R., additional, and Mulert, C., additional

Published
2008
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177. Cell-mediated immunity and its glucocorticoid-sensitivity after clinical recovery from severe major depressive disorder

Author

Wodarz, Norbert, Rupprecht, R., Kornhuber, J., Schmitz, B., Wild, K., and Riederer, P.

Subjects
Adult, Male, ddc:610, Dose-Response Relationship, Drug, 610 Medizin, Lymphocyte Activation/immunology, Middle Aged, Hydrocortisone/blood, Dexamethasone/diagnostic use, Receptors, Glucocorticoid/physiology, Humans, Female, Depressive Disorder/immunology, Adrenocorticotropic Hormone/blood
Abstract

This follow-up study investigated lymphocyte blastogenesis induced by concanavalin A, phytohemagglutinin A, and pokeweed mitogen and their sensitivity to in vitro dexamethasone administration in 12 patients clinically recovered from severe major depression. Although cortisol-levels at 4.00 p.m. decreased significantly after clinical remission, mitogen-driven lymphocyte proliferative responses were unchanged when assessed intra-individually. No impairment of in vitro glucocorticoid-sensitivity of lectin-induced lymphocyte blastogenesis could be observed in clinically recovered patients. The inhibitory potency of in vitro dexamethasone was found to be inversely correlated with in vivo adrenal cortical hormone levels. There were no correlations with age, weight, sex, antidepressant medication, severity or duration of depression. No differences from age- and sex-matched healthy individuals were found. These results indicate that reduced glucocorticoid receptor sensitivity occurs only during the acute depressive illness.

Published
1992

178. Late adverse effects after soft X‐ray therapy of cutaneous malignancies: pruritus, burning, epiphora and insufficient occlusion of the mouth

Author

Schulte, K‐W, primary, Auras, C, additional, Bramkamp, G, additional, Breitkopf, C, additional, Elsmann, H‐J, additional, Habenicht, EM, additional, Jasnoch, V, additional, Lippold, A, additional, Lösler, A, additional, Rupprecht, R, additional, Müller‐Pannes, H, additional, and Suter, L, additional

Published
2007
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186. Whole genome analysis reveals new potential drug targets as predictors of antidepressant treatment response

Author

Lucae, S, primary, Marcus, I, additional, Saemann, P, additional, Bettecken, T, additional, Uhr, M, additional, Ripke, S, additional, Kohli, M, additional, Kloiber, S, additional, Bondy, B, additional, Rupprecht, R, additional, Domschke, K, additional, Arolt, V, additional, Lichtner, P, additional, Holsboer, F, additional, and Müller-Myhsok, B, additional

Published
2007
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187. In vivo and in vitro effects of glucocorticoids on lymphocyte proliferation in depression

Author

Rupprecht, R., Wodarz, Norbert, Kornhuber, J., Wild, K., Schmitz, B., Braner, H.-U., Müller, O. A., Riederer, P., and Beckmann, H.

Subjects
Adult, Male, ddc:610, Adolescent, Dexamethasone/pharmacology, 610 Medizin, chemical and pharmacologic phenomena, Lymphocyte Activation/immunology, Middle Aged, Hydrocortisone/blood, Bipolar Disorder/immunology, Receptors, Glucocorticoid/physiology, Metyrapone/pharmacology, Humans, Female, Depressive Disorder/immunology, Adrenocorticotropic Hormone/blood, Aged
Abstract

Twelve severely depressed patients and 13 healthy controls were studied under baseline, metyrapone and metyrapone plus dexamethasone pretreated conditions. Lymphocyte proliferation data were obtained by concanavalin A, phytohaemagglutinin and pokeweed mitogen (PWM) stimulation. There was a decrease in PWM-induced B-cell proliferation and an increase in inhibition of spontaneous leucocyte proliferation by dexamethasone added in vitro following metyrapone administration in vivo, in healthy controls, which was not present in the depressed patients. These data support the concept of a decreased functional plasticity of the glucocorticoid receptor in depression also at the cellular level.

Published
1991

188. Lymphocyte glucocorticoid receptor binding during depression and after clinical recovery

Author

Rupprecht, R., Kornhuber, J., Wodarz, Norbert, Lugauer, J., Göbel, C., Riederer, P., and Beckmann, H.

Subjects
Adult, Male, ddc:610, Adolescent, 610 Medizin, Bipolar Disorder/psychology, Middle Aged, Antidepressive Agents/therapeutic use, Hydrocortisone/blood, Lymphocytes/metabolism, Recurrence, Humans, Female, Depressive Disorder/psychology, Adrenocorticotropic Hormone/blood, hormones, hormone substitutes, and hormone antagonists, Aged, Receptors, Glucocorticoid/metabolism
Abstract

Lymphocyte glucocorticoid receptor binding parameters were studied in 15 severely depressed patients during depression and after clinical recovery, and in 15 healthy controls. There was no difference in glucocorticoid receptor number or affinity between depressed patients and recovered or control subjects. Afternoon ACTH and cortisol concentrations did not differ significantly between the three groups. No relationship could be established between glucocorticoid receptor binding and antidepressant medication. These data support the view of an impaired ligand-induced plasticity of glucocorticoid receptor regulation rather than the hypothesis of decreased glucocorticoid receptor numbers during depression.

Published
1991

189. Normal lymphocyte responsiveness to lectins but impaired sensitivity to in vitro glucocorticoids in major depression

Author

Wodarz, Norbert, Rupprecht, R., Kornhuber, J., Schmitz, B., Wild, K., Braner, H. U., and Riederer, P.

Subjects
Adult, Male, Phytohemagglutinins/immunology, ddc:610, Dexamethasone/pharmacology, 610 Medizin, Lymphocyte Activation/immunology, Middle Aged, Hydrocortisone/blood, Immune Tolerance/immunology, Immunity, Cellular/immunology, Humans, Female, Depressive Disorder/immunology, Adrenocorticotropic Hormone/blood, Cells, Cultured
Abstract

The mitogen-induced lymphocyte proliferative response and its sensitivity to in vitro (10(-10)-10(-6) M) dexamethasone (DEX) administration were investigated in 12 severely depressed patients and 13 healthy controls. Patients with major depressive disorder exhibited no impairment of lectin-induced blastogenesis, but a significantly weaker suppressive effect of in vitro DEX on 1.0 microgram/ml phytohemagglutinin A-induced proliferation. The inhibitory potency of in vitro DEX was inversely correlated with in vivo adrenal cortical hormone levels at 4.00 p.m. These effects were not observed with pokeweed mitogen- and concanavalin A-stimulated cells. There were no correlations with age, weight, sex or severity of depression. These results do not support the hypothesis of a primarily impaired cell-mediated immunity, but might be indicative of reduced glucocorticoid receptor sensitivity in major depressive disorder.

Published
1991

196. Glucocorticoid receptors on mononuclear leukocytes in Alzheimer's disease

Author

Rupprecht, R., Frölich, L., Mergenthaler, T., Kornhuber, J., Wodarz, Norbert, Riederer, P., and Maurer, K.

Subjects
Male, Leukocytes, Mononuclear/metabolism, ddc:610, Alzheimer Disease/blood, 610 Medizin, Hypothalamo-Hypophyseal System/physiopathology, Middle Aged, Hydrocortisone/blood, Humans, Female, Immunoradiometric Assay, Pituitary-Adrenal System/physiopathology, Glucocorticoid receptors, Alzheimer’s disease, aging, Adrenocorticotropic Hormone/blood, Aged, Receptors, Glucocorticoid/metabolism
Abstract

Several lines of evidence suggest disturbances of the hypothalamic-pituitary-adrenal (HPA) system in Alzheimer's disease (AD). In an exploration of the potential role of the glucocorticoid receptor (GR) in AD, GR density and affinity were assessed on mononuclear leukocytes of 12 AD patients and 12 healthy controls. GR binding characteristics did not differ between patients and controls or between patients subdivided according to diagnosis or associated clinical features. These data suggest that the abnormalities of the HPA system in AD are not related to a GR deficiency.

Published
1990

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