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Background: The impact of de-escalation of antiplatelet therapy retains P2Y12 inhibitor on major bleeding and ischemic outcomes after percutaneous coronary intervention (PCI) among East Asians and non-East Asians was unclear.Methods: We systematically searched PubMed, Embase and the Cochrane Library for randomized controlled trials through September 2020. Eight trials were included, which studied de-escalation of DAPT (D-DAPT, switching to P2Y12 inhibitor monotherapy or decreasing the intensity of P2Y12 inhibitor after 1 to 3 months) versus 12 months standard DAPT (S-DAPT). The primary outcomes data were conducted with random effects models.Results: Among 8 included trials with 37,775 patients, 62.6% of patients presented with acute coronary syndrome. The median follow-up duration ranged from 12 to 24 months. Compared with S-DAPT, D-DAPT was associated with a lower risk of major bleeding (RR=0.64, 95%CI: 0.47-0.88, p=0.006), but this was only observed among East-Asians (RR=0.55, 95%CI: 0.38-0.81, p=0.002). Among non-East Asians, the rate of major bleeding was similar between two groups (RR=0.73, 95% CI: 0.46-1.14, p=0.17). There was no significant difference of MACE between D-DAPT and S-DAPT treatment among both East Asians (RR=0.84, 95%CI: 0.66-1.08, p=0.18) and non-East Asians (RR=0.89, 95%CI: 0.79-1.00, p=0.05).Conclusions: De-escalation strategy retains P2Y12 inhibitor after PCI was associated with reduced risk of bleeding events, which was only demonstrated in East Asians patients, but not in non-East Asians patients.

Pigment-synthesizing melanoma (PSM) describes a morphologically and genetically diverse group of melanomas. In contrast, pigmented epithelioid melanocytoma (PEM) encompasses a spectrum of indolent tumors now classified as borderline/intermediate melanocytic tumors. Herein, we report a case of widely metastatic heavily pigmented epithelioid melanoma with fatal outcome in a 36-year-old woman. Next-generation sequencing identified somatic (tumoral) mutations in BRAF V600E, PTEN, NOTCH1, and ERBB3. By contrast, GNAQ and GNA11 were wild type. Prkar1α and p16 expression were maintained. Identification of mutations in NOTCH1 and ERBB3 may support the diagnosis of heavily pigmented epithelioid melanoma. In contrast, PRKCA fusion genes and PRKAR1A mutations support the diagnosis of PEM. Given the heterogeneity, potential overlap (loss of Prkar1α expression), and evolving genetic profiles of these two distinct groups of tumors, careful appraisal of molecular profiles in the light of histomorphology and clinical history is necessary for distinction between PEM and PSMs including heavily pigmented epithelioid melanomas, with significant potential impact on prognosis and therapy.

BackgroundThe impact of sex on the association of obstructive sleep apnoea (OSA) with recurrent cardiovascular events following acute coronary syndrome (ACS) remains uncertain. This study sought to examine the association between OSA and long-term cardiovascular outcomes in women and men with ACS.MethodsIn this prospective cohort study, we recruited 2160 ACS patients undergoing portable sleep monitoring between June 2015 and January 2020. The primary end-point was major adverse cardiovascular and cerebrovascular event (MACCE), including cardiovascular death, myocardial infarction, stroke, ischaemia-driven revascularisation or hospitalisation for unstable angina or heart failure.ResultsAfter exclusion of patients with failed sleep studies, central sleep apnoea, regular continuous positive airway pressure therapy and loss of follow-up, 1927 patients were enrolled. Among them, 298 (15.5%) were women and 1014 (52.6%) had OSA (apnoea–hypopnoea index ≥15 events·h−1). The prevalence of OSA was 43.0% and 54.4% in women and men, respectively. In 4339 person-years (median 2.9 years, interquartile range 1.5–3.6 years), the cumulative incidence of MACCE was significantly higher in OSAversusnon-OSA groups in the overall population (22.4%versus17.7%; adjusted hazard ratio (HR) 1.29, 95% CI 1.04–1.59; p=0.018). OSA was associated with greater risk of MACCE in women (28.1%versus18.8%; adjusted HR 1.68, 95% CI 1.02–2.78; p=0.042), but not in men (21.6%versus17.5%; adjusted HR 1.22, 95% CI 0.96–1.54; p=0.10). No significant interaction was noted between sex and OSA for MACCE (interaction p=0.32). The incremental risk in women was attributable to higher rates of hospitalisation for unstable angina and ischaemia-driven revascularisation.ConclusionsIn hospitalised ACS patients, OSA was associated with increased risk of subsequent events, particularly among women. Female patients with ACS should not be neglected for OSA screening and dedicated intervention studies focusing on women with ACS and comorbid OSA should be prioritised.

Enteric duplication cysts (EDCs) are rare congenital malformations consisting of double-walled cystic or tubular structures lined by gastrointestinal type epithelium. EDCs share a common muscular wall and blood supply with the adjacent duplicated bowel with very rare exceptions. The majority of EDCs are intraabdominal with cases less commonly intrathoracic or thoracoabdominal. To the best of our knowledge, we present the first reported case of primary cutaneous EDC to occur outside the abdominal and thoracic cavities. A 17-year-old male without a significant medical or surgical history underwent excision of a cystic nodule on the left hip. On histopathology, a dermal to subcuticular cyst exhibited an epithelial lining with 2 distinct components including cuboidal to columnar mucinous cells (CK7+, CK20-, and CDX2-) and complex glandular colonic-type mucosa (CK7-, CK20+, and CDX2+). A thick muscular wall resembling muscularis mucosa and muscularis propria surrounded the cyst. Findings supported a primary cutaneous enteric duplication cyst of uncertain developmental etiology. The novel nature of this entity could represent a diagnostic challenge.

Background: DNA polymerase epsilon (POLE) is encoded by the POLE gene, and POLE-driven tumors are characterized by high mutational rates. POLE-driven tumors are relatively common in endometrial and colorectal cancer, and their presence is increasingly recognized in ovarian cancer (OC) of endometrioid type. POLE-driven cases possess an abundance of TCT>TAT and TCG>TTG somatic mutations characterized by mutational signature 10 from the Catalog of Somatic Mutations in Cancer (COSMIC). By quantifying the contribution of COSMIC mutational signature 10 in RNA sequencing (RNA-seq) we set out to identify POLE-driven tumors in a set of unselected Mayo Clinic OC. Methods: Mutational profiles were calculated using expressed single-nucleotide variants (eSNV) in the Mayo Clinic OC tumors (n=195), The Cancer Genome Atlas (TCGA) OC tumors (n=419), and the Genotype-Tissue Expression (GTEx) normal ovarian tissues (n=84). Non-negative Matrix Factorization (NMF) of the mutational profiles inferred the contribution per sample of four distinct mutational signatures, one of which corresponds to COSMIC mutational signature 10. Results: In the Mayo Clinic OC cohort we identified six tumors with a predicted contribution from COSMIC mutational signature 10 of over five mutations per megabase. These six cases harbored known POLE hotspot mutations (P286R, S297F, V411L, and A456P) and were of endometrioid histotype (P=5e-04). These six tumors were hypermutated with a higher tumor mutation load (mean, 54.02 mutations per megabase) compared to non-POLE endometrioid OC cases (mean, 7.69 mutations per megabase; P=5e-04), and had an early onset (average age of patients at onset, 48.33 years) when compared to non-POLE endometrioid OC cohort (average age at onset, 60.13 years; P=.008). Samples from TCGA and GTEx had a low COSMIC signature 10 contribution (median 0.16 mutations per megabase; maximum 1.78 mutations per megabase) and carried no POLE hotspot mutations.Conclusions: From the largest cohort of RNA-seq from endometrioid OC to date (n=53), we identified six hypermutated samples likely driven by POLE (frequency, 11%). Our result suggests the clinical need to screen for POLE driver mutations in endometrioid OC, which can guide enrollment in immunotherapy clinical trials.

According to the existing air quality forecasting model, this paper proposed an air quality forecasting method based on deep learning. By analyzing forecasting data, monitoring data and meteorological data, a new air quality forecasting model in the region is established. The model fully takes into account the time variability and spatial distribution characteristics of air pollutant concentration, and introduces meteorological data as covariates to predict any location in the study area.

Background. Obstructive sleep apnea (OSA) is closely related to the incidence and progression of coronary artery disease (CAD), and the mechanisms linking OSA and CAD are multifactorial. C1q/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling. We aimed to ascertain the clinical relevance of CTRP9 with OSA prevalence in patients with CAD. Methods. From August 2016 to March 2019, consecutive eligible patients with CAD (n=154; angina pectoris, n=88; acute myocardial infarction [AMI], n=66) underwent cardiorespiratory polygraphy. OSA was defined as an apnea-hypopnea index (AHI) ≥15 events·h−1. Plasma CTRP9 concentrations were measured by ELISA method. Results. Moderate/severe OSA was present in 89 patients (57.8%). CTRP9 levels were significantly decreased in the moderate/severe OSA group than in the no/mild OSA group (4.7 [4.1-5.2] ng/mL vs. 4.9 [4.4-6.0] ng/mL, P=0.003). The difference between groups was only observed in patients with AMI (3.0 [2.3-4.9] vs. 4.5 [3.2-7.9], P=0.009). Correlation analysis showed that CTRP9 levels were negatively correlated with AHI (r=−0.238, P=0.003) and oxygen desaturation index (r=−0.234, P=0.004) and positively correlated with left ventricular ejection fraction (r=0.251, P=0.004) in all subjects. Multivariate analysis showed that male gender (OR 3.099, 95% CI 1.029-9.330, P=0.044), BMI (OR 1.148, 95% CI 1.040-1.268, P=0.006), and CTRP9 levels (OR 0.726, 95% CI 0.592-0.890, P=0.002) were independently associated with the prevalence of moderate/severe OSA. Conclusions. Plasma CTRP9 levels were independently related to the prevalence of moderate/severe OSA in patients with CAD, suggesting that CTRP9 might play a role in the pathogenesis of CAD exacerbated by OSA.

Threats of bacterial infection represent one of the most persistent issues of public health, and efficient bacteria killing materials are to be developed. Taking inspirations from nature, a new class of halloysite (Hal)-based bacteria killing materials (MnOx-Ag/Hal) that were able to self-move in aqueous solution was prepared. The asymmetric halloysite tubes are used as substrates. Silver (Ag) nanoparticles are loaded both in the lumen and on the external surface, and manganese oxide (MnOx) was distributed on the outside walls. Fuel with low concentration of H2O2, the catalyst Ag and MnOx would decompose H2O2 into gas bubbles (O2), and the back-thrust bubbles provided forward forces for jet movement, which improved the antibacterial efficiency. The fabricated MnOx-Ag/Hal exhibited powerful self-propelled motion with velocity of 18 ± 4 μm/s achieved at 0.2 wt% H2O2. The MnOx-Ag/Hal generated Ag+ ions and highly reactive oxygen species that could efficiently kill E. coli. By coupling the antibacterial capabilities of H2O2, Ag and highly reactive oxygen species with powerful self-propulsion, the prepared micromotors were capable of killing 97% of E. coli within 2.0 min, which was threefold as the counterpart of MnOx-Ag/Hal in the absence of H2O2 that cannot move efficiently. The biocompatible micromotors offered an encouraging strategy for rapid bacteria killing in clinical and environment fields.

The aim of next-generation Computer Numerical Control (CNC) is shifting from an open architecture, which has better flexibility, adaptability, versatility and expansibility, to a cyber-physical model, which offers real-time monitoring and control of the machining processes. This paper introduces a real case study to demonstrate such tendency from Open CNC systems to Cyber-Physical Machine Tools (CPMT) based on a low-power embedded platform. Firstly, a new open CNC architecture is presented, which is able to achieve high-precision, high-efficiency, and low-power consumption. Secondly, the open CNC architecture is extended to a CPMT by using Wireless Sensor Networks (WSN), where WSN is utilized to enable monitor and control the machining processes, and the integrated development platform is termed as CPMT. Finally, a case of health monitoring system for CPMT is designed and its system testing is carried out. Published version

Cyber-Physical Production Systems (CPPS) often use wireless sensor networks (WSNs) for monitoring purposes. However, data from WSNs may be inaccurate and unreliable due to power exhaustion, noise and other issues. In order to achieve a reliable and accurate data acquisition while ensuring low energy consumption and long lifetime of WSNs, data cleansing algorithms for energy-saving are proposed in this research. The cleansing algorithms are computationally lightweight in local sensors and energy-efficient due to low energy consumption in communications. Dynamic voltage scaling and dynamic power management are adopted for reducing energy consumption, without compromising the performance at system level. A low-power protocol for sink node communication is proposed at network level. A health monitoring system for a Cyber-Physical Machine Tool (a typical example of CPPS) is designed. Experiment results show that the proposed energy-saving data cleansing algorithm yields high-performance and effective monitoring.

Calciphylaxis is a rare syndrome of vascular calcification with thrombosis that occurs most often in patients with end-stage renal disease, and it frequently portends a guarded prognosis. Rarely, nonuremic calciphylaxis (NUC) may occur; in this context, a strongly supportive histology is crucial in establishing the diagnosis. Herein, we describe 2 cases of NUC associated with pseudoxanthoma elasticum-like changes, identified in both initial nondiagnostic and subsequent diagnostic biopsy specimens. This unusual but helpful histologic finding may support the early diagnosis and treatment of a potentially life-threatening disease in the context of subtle histopathologic vascular changes or in the absence of classic clinical or laboratory findings.

Computer numerical control (CNC) systems are shifting to a direction of open architecture which has better flexibility, adaptability, versatility, and expansibility. Existing CNC systems tend to have a high level energy consumption. This paper introduces a new open CNC system based on the low-power embedded platform, named open and high-performance CNC (OHP-CNC). OHP-CNC is able to achieve high precision, high efficiency, and low power consumption by making use of international standards, open components such as hardware and software, and an energy-aware real-time scheduling algorithm. The proposed algorithm for mixed tasks, including periodic and aperiodic tasks, is divided into two phases. Firstly, the slack time and utilization are calculated on each processor and tasks are assigned to the processor according to the load. Secondly, because there is a trade-off between the energy-saving and the response times of the aperiodic task, the scheduling server is used to schedule aperiodic tasks in order to meet the response time constraints of aperiodic tasks. Meanwhile, periodic tasks recycle the slack time with dynamic voltage scaling technology to achieve low power consumption. Experiment results show that the energy-aware real-time algorithm yields high-performance and effective machining processes.

The mean activity coefficients of the ternary systems CsCl + polyethylene glycol (PEG) (w) + H2O (1 – w) (w = 10%, 20%, 30%, 40%) determined by the potentiometric method at T = 298.15 K are reported. The molecular weights of PEG are 200 and 600, and the CsCl molality varies from 0.01 to 4.00 mol/kg. To correlate the experimental data, the Pitzer equation, extended Debye–Huckel equation, and the modified Pitzer equation have been utilized herein. As a result, a series of thermodynamic parameters were obtained and discussed in detail, including the mean ionic activity coefficients (γ±), the osmotic coefficient (Φ), the excess Gibbs free energies (GE), the standard Gibbs free energy of transference (ΔGt0) and the primary hydration number (nhydr).

Amicrobial pustulosis of the folds (APF) is a rare disease characterized by aseptic pustular lesions involving cutaneous folds, typically occurring in the context of an autoimmune disorder. We present 4 patients with APF, focusing on clinical and histopathologic characteristics to improve the recognition of this entity. All 4 patients had intertriginous and extra-intertriginous involvement. Common histopathologic features of skin biopsies in these patients were intracorneal, subcorneal, intraepidermal, perivascular, perifollicular and interstitial neutrophilic inflammation. Pustules overlying adnexal ostium and papillary dermal edema were consistently observed. The pustules were negative for microorganisms on stain testing. In these cases, associated conditions were undifferentiated connective tissue disease, systemic lupus erythematosus, antiphospholipid syndrome, Crohn disease and Hashimoto thyroiditis. The aforementioned clinical and histopathologic characteristics of patients with suspected or diagnosed connective tissue disorders should lead to suspicion for APF.

The effect of A site deficiency on the electrochemical performance of a strontium-doped lanthanum manganite (LSM) cathode in an ScSZ electrolyte-supported solid oxide fuel cell (SOFC) was investigated. XRD characterization resulted in a series of (La 0.75 Sr 0.25 ) x MnO 3 (x=1.0, 0.97, 0.95, 0.9 and 0.85) powders, indicating that the Mn 3 O 4 phase precipitated into (LS) x M when the deficiency value was over a certain threshold value. The chemical reaction occurred between stoichiometric LSM and ScSZ due to the high chemical potential of La. An A site deficiency in the LSM can reduce the chemical potential of La and suppress the interfacial reaction between the LSM and ScSZ. The precipitation of Mn 3 O 4 due to a larger A site deficiency leads to the formation of LZO occurring at the A site-deficient (LS) x M and ScSZ. An A site-deficient (LS) x M cathode appears to possess good adhesion with the ScSZ electrolyte and a longer active TPB length after being sintered at 1300 °C. An optimal A site deficiency concentration was considered to exist in the electrochemical performance improvement of the A site-deficient LSM cathode SOFC.

Polyurethane (PU) sponge has a wide range of applications in our daily life. Unfortunately, the PU sponge is highly flammable and becomes a breeding ground for bacteria, thereby threatening human health and life. To date, it remains a challenge to improve the flame retardant and antibacterial properties of PU sponge simultaneously without destroying its inherent elasticity and flexibility. Here we report a novel composite coating on the PU sponge using bioderived phytic acid and sodium lignosulfonate via a facile soaking method. Compared to the pristine sponge, the coated PU sponge can reach a 32% reduction in peak heat release rate during cone calorimeter test, and prevent melt dripping after being ignited by a butane torch and the flame can be self-extinguished after the torch is removed. The resultant composite coating also demonstrates a killing rate of 99% against Staphylococcus aureus. Meanwhile, the coated PU sponge can retain the inherent elasticity and flexibility even after 500 cycles of compression. Furthermore, the coating materials are easily recyclable, which provide a useful reference for multifunctional treatment of sponge and cyclic utilization of resources.

Serous borderline ovarian tumor (SBOT) and high-grade serous ovarian cancer (HGSOC) are two distinct subtypes of epithelial ovarian tumors, with markedly different biologic background, behavior, prognosis, and treatment. However, the histologic diagnosis of serous ovarian tumors can be subjectively variable and labor-intensive as multiple tumor slides/blocks need to be thoroughly examined to search for these features. In this study, we aimed to evaluate technical feasibility of using digital pathological approaches to facilitate objective and scalable diagnosis screening for SBOT and HGSOC. Based on Groovy scripts and QuPath, a novel informatics system was developed to facilitate interactive annotation and imaging data exchange for machine learning purposes. Through this developed system, cellular boundaries were detected and expanded set of cellular features were extracted to represent cell- and tissue-level characteristics. According to our evaluation, cell-level classification was accurately achieved for both tumor and stroma cells with greater than 90% accuracy. Upon further re-examinations, 44.2% of the misclassified cells were due to over-/under-segmentations or low-quality of imaging areas. For a total number of 6,485 imaging patches with sufficient tumor and stroma cells (ten of each at least), we achieved 91-95% accuracy to differentiate HGSOC v. SBOT. When all the patches were considered for a WSI to make consensus prediction, 97% accuracy was achieved for accurately classifying all patients, indicating that cellular features digitally extracted from pathological images can be used for cell classification and SBOT v. HGSOC differentiation. Introducing digital pathology into ovarian cancer research could be beneficial to discover potential clinical implications., Comment: 17 pages, 8 figures

Background Periodic Acid Schiff-Diastase (PAS-D) staining is used routinely in dermatopathology. Conventionally, parakeratosis or intracorneal neutrophils justify use of PAS-D stain to identify dermatophytosis. We aimed to investigate the histopathological features of superficial dermatophytosis. Methods Skin biopsies with PAS-D stain were retrospectively reviewed by a blinded dermatopathologist. Histopathologic findings in cases with dermatophytosis were compared to those without. Results We studied 110 cases, of which 63 were PAS-D positive for dermatophytes. Dermatophytes were identified on H&E staining in 49 (77.8%) of the PAS-D-positive cases. Diffuse compact orthokeratosis (79.37%, p

Nodular fasciitis (NF) is a clonal self-limited neoplastic proliferation characterized by rearrangements of the USP6 locus in most examples. To our knowledge well-documented malignant behavior has never been previously observed in NF. In this report we present an unusual case of NF with classical histologic features that showed a protracted clinical course characterized by multiple recurrences and eventual metastatic behavior over a period of 10 years. Molecular analyses revealed the presence and amplification of the novel PPPR6-USP6 gene fusion, which resulted in USP6 mRNA transcriptional upregulation. These findings further support the oncogenic role of the USP6 protease in mesenchymal neoplasia and expand the biologic potential of NF. © 2016 Wiley Periodicals, Inc.

Hydrogen sulfide (H2S) causes malodor, health disorders, and equipment corrosion, but is a constituent of a wide range of valuable gases. For efficient H2S removal, biochars derived from rice hull and loaded with four alkalis (NaOH, KOH, Na2CO3, and K2CO3) were prepared by impregnation. The H2S removal characteristics were investigated by continuous adsorption column tests. The alkaline impregnated biochars (IBCs) showed superior H2S removal performance compared to that of coconut shell activated carbon (AC) due to the enhanced chemical adsorption. The removal capacity varied depending on the alkalis and their concentration of aqueous solution for impregnation. The IBC with 5 M of NaOH solution afforded the highest removal capacity of 24.41 mg/g, which greatly exceeded 7.65 mg/g of the AC. Moreover, the height-to-diameter ratio, inlet gas flow rate, H2S gas concentration, temperature, and inlet gas moisture influenced the adsorption capacity, which mainly affect the contact and reaction between H2S and the alkali impregnated on rice hull biochar.

e15184 Background: Clinical responses to anti-PD1 immunotherapy in patients with metastatic melanoma (MM) remain challenging to predict. This clinical heterogeneity is also reflected in the tumor-immune microenvironment among patients and within a single tumor lesion. With the emergence of multiplex imaging platforms, defining complex phenotypes at single cell resolution has become possible. Here, we sought to objectively quantify paracrine tumor-immune interactions contributing to the variable clinical responses observed in patients receiving anti-PD1 therapy. Methods: Excisional lymph node (LN) biopsies were obtained from treatment-naïve patients with MM who underwent subsequent anti-PD1 therapy. A single 5µm section of LN tissue was used to assess a 42 analyte panel by multiplex immunofluorescence. From 30 LN samples, 418 fields of view (FOVs) were selected resulting in 14,360 high-resolution images of 4 anatomical subregions: tumor core, tumor-immune interface, tumor infiltrate and adjacent immune stroma. Following image processing, we developed an adaptive classification for tumor-centric cellular neighborhoods (TCCN) to identify and quantify critical paracrine interactions within the tumor-immune microenvironment. Results: Stratification based on responsiveness to anti-PD1 therapy resulted in 4 complete responders (CR) and 12 non-responders (NR) at 12-week follow-up. From 126 FOVs, we defined the cellular composition of 197,865 TCCN across patients based on clinical response and LN subregions. Overall, the percentage of TCCN devoid of any T cells, B cells or macrophages was significantly higher in NR compared to CR irrespective of subregion. However, other markers differentiated TCCN based on subregion. Specifically in CR, tumor core regions were enriched for CD8 T cells, while enrichment for B cells and endothelial cells was demonstrated at the tumor-immune interface. Strikingly, tumor infiltrate regions demonstrate robust immune reactivity with enrichment for M1 polarized macrophages, NK cells and B cells in CR compared to NR. Complete data from the 30 patient cohort across 418 FOVs will be presented. Conclusions: Taken together, this data suggests cellular composition of TCCN across subregions of the LN is dynamic within a single metastatic site. In this small cohort, we introduce a formalized stratification to quantify and classify critical paracrine interactions within the immune-tumor microenvironment with the potential to inform clinical responsiveness to therapy.

At present, the embedded real-time system should not only guarantee the real-time performance of tasks, but also consider the energy consumption of the system. In this paper, a low power scheduling algorithm based on periodic task model is proposed. This algorithm is a two-stage scheduling algorithm, which calculates the best processor speed in the offline stage, reclaims and distributes slack time at the running stage to save energy. Experiments show that the proposed algorithm is more efficient than the existing algorithm in saving energy.

Cardiac rupture (CR) is a complication of acute myocardial infarction (AMI) that is associated with a high mortality rate. This study aimed to identify the risk factors for CR in patients with AMI. Medline, Cochrane, EMBASE, and Google Scholar databases were searched for relevant literature published through September 16, 2018. Eligible studies included patients with AMI and compared factors between patients with and without CR. Sixteen studies were identified and included in the meta-analysis. Results revealed that female gender (pooled OR=2.72, 95% CI 2.04 to 3.63, p

Energy consumption is an important issue in the research of embedded real-time system scheduling. In this paper, a low power scheduling algorithm based on total bandwidth server is proposed for real-time system mixed task set model. This algorithm is a two-stage scheduling algorithm, which calculates the best processor speed in the offline stage, reclaims and distributes slack time at the running stage, and reduces the processor frequency to save energy. Experiments show that the proposed algorithm is more efficient than the existing total bandwidth server scheduling algorithm.

Traditional manufacture assembly fault detection method more relied on manual operation leading to an ineffective procedure. In order to solve the problem making mistakes caused by manual inspection such as missing installations or lack of visual and intuitive guidance in traditional manufacturing assembly, A method of manufacture assembly fault detection based on deep learning and mixed reality is proposed. By training a pretreatment model and detecting targets via Faster R-CNN convolutional neural network, the accurate and efficient assembly detection is realized in the manufacturing by extracting feature information. Meanwhile, the mixed reality combination is realized by using the mixed reality device HoloLens as the human-computer interaction module to access the system. Augmented information interactions make the manufacturing and assembly inspection process more visual and intuitive. The experimental results show that the method proposed has a higher detection accuracy, a better user experience and a great capacity on an efficient assembly detection.

Deep Learning is the latest research achievement in the field of Artificial Intelligence. To detect and identify the state of circuit breaker in ambient air automatic monitor station, Deep Learning was proposed to realize the circuit breaker state recognition in real-time. The Deep Convolutional Neural Network was used to construct the state detection and identification model of the circuit breaker and provided the detection process. The remote monitoring system of ambient air automatic monitor station and inspection data were used to build the experimental data platform, with the circuit breaker state recognition data was acquired from the multiple ambient air automatic monitor stations. Through training the model with the Deep Learning, the experimental results showed that the circuit breaker state detection and identification method have a simple recognition process and high accuracy. The real-time Detection and Identification function of the circuit breaker state was realized, meanwhile, the assistant decision-making function was provided to the ambient air automatic monitor station.

In order to solve the problem of improving the construction efficiency of 3D visualization application, this paper presents the management model based on 3D visualization service platform. First we have studied the traditional method of 3D application building, and we propose 3D visualization platform architecture. Based on this, we put forward the visual management model based on actor, components, the message (ACM). Through studying message manager structure and actor model in depth, we can quickly build actor models, dynamically bind with skills, algorithms, and extend attributes to meet the needs of dynamically building 3D applications. The "model-instance" design concept is used to greatly reduce the workload of developers and improve efficiency. In addition, the improved load balancing strategy is adopted to improve the visualization system. The experimental results have demonstrated our management model achieves simply, effectively reduce the cost of developing 3D visualization application. It is able to build 3D applications dynamically, and it has characteristics of high cohesion, low coupling between modules, easy extension and maintenance. What’s more, it also has good performance in the multi-terminal simulation experiments.

We report herein two cases of reactive capillary hemangiomas during the clinical trials of SHR-1210, a humanized anti-PD-1 IgG4 antibody.A female in her 20s with a history of stage IVa Hodgkin's ly...

Capillary hemangiomas, the most common vascular tumors of the sinonasal region, are benign endothelial neoplasms, typically growing in an easily recognized lobular pattern. Some sinonasal capillary hemangiomas may show atypical features, such as high cellularity or mitotic activity, and represent more challenging diagnoses. Over the past several years we have seen in consultation a number of examples of sinonasal capillary hemangiomas displaying very striking stromal myxoid change and hyalinization, features that have received scant attention in the past. Available slides from 16 sinonasal capillary hemangiomas previously coded as showing such changes were retrieved from our archives. Submitting diagnoses included "query angiofibroma, rule out malignancy" (N=4), "vascular polyp, rule out malignancy" (N=3), "query malignant vascular tumor" (N=4), "sinonasal hemangiopericytoma" (N=1), and "benign vascular tumor" (N=1). Available radiographic studies often showed worrisome features. Grossly, the tumors ranged from 1.1 to 6.0 cm and appeared as ulcerated, vascular-appearing polyps. Microscopically, the tumors showed striking stromal myxoid change and/or hyalinization, which largely obscured the underlying lobular capillary arrangement. Within this myxohyaline matrix, a florid capillary proliferation was present, frequently with nonatypical mitotic activity. In some instances a branching, "hemangiopericytoma-like" vascular pattern was present in areas. The overall cellularity was low to moderate, and endothelial atypia or hyperchromatism was absent. Ulceration and thrombosis were frequently present. Immunostains to CD31, CD34, and SMA highlighted areas of lobular growth pattern inapparent on the routinely stained slides. Four tested cases were negative for androgen receptors and β-catenin. Follow-up from 12 patients revealed no local recurrences or metastases. Awareness of that sinonasal capillary hemangioma may show these unusual stromal changes, and the use of ancillary immunohistochemistry to highlight its lobular growth pattern should allow its confident distinction from more aggressive endothelial tumors (eg, angiosarcoma) and from nonendothelial tumors, including nasopharyngeal angiofibroma, solitary fibrous tumor, and sinonasal hemangiopericytoma-like tumor.

To investigate the chemical compatibility of A-site deficient LST anode and stabilized zirconia electrolyte, (La0.25Sr0.75)xTiO3 (x=0.86, 0.88, 0.885, 0.887 and 0.89) powders were prepared by sol-gel method. TiO2 precipitated in each LST sample except LST-0.89. The amount of TiO2 precipitated in A-site deficient LST increased with the increasing of A-site deficiency concentration. Phase change of as-prepared LST and ScSZ composite pellets after annealed at 1200 oC in air was characterized by XRD. Diffusion of Ti from LST into ScSZ at elevated temperature was enhanced with the increasing of TiO2 precipitated in LST. Diffusion of Zr and Sc from ScSZ into LST occurred in LST-0.89/ScSZ, LST-0.887/ScSZ, LST-0.885/ScSZ and LST-0.86/ScSZ pellets. No obvious phase change was observed in LST-0.88/ScSZ, hence LST-0.88 was considered to possess relatively good chemical compatibility with ScSZ.

Lymphomatoid drug reactions can mimic endogenous T and B cell lymphoproliferative diseases.We present a novel form of cutaneous drug reaction with features of pityriasis lichenoides (PL), a recognized form of T cell dyscrasia.Ten cases were studied where a cutaneous eruption exhibiting semblance to PL within a few weeks to months after starting a particular drug.The patient cohort comprised 7 females and 3 males with the mean age of 60 years. Widely distributederythematous cutaneous lesions were present in 6 cases whereas a more localized distribution was seen in three cases. The most frequently implicated drugsassociated with the eruption were antidepressants and statins. Histologic examination showed a morphologic picture identical to PL including marked epitheliotropism of mildly atypical lymphocytes, psoriasiform epidermal hyperplasia, dyskeratosis, hemorrhage, and a thick parakeratotic scale. Therewas a significant reduction in the expression of CD7 and CD62L amid the T cells. Regression of the eruption occurred in all cases excluding one.Thefindings conform the categorization of this process as a form of T-cell dyscrasia albeit one that is reversible, dependent on the drug withdrawal. The limitationof our study includes the retrospective design of the study.