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1,018 results on '"Rowe, Steven M."'

156. Inhaled gene therapy of preclinical muco-obstructive lung diseases by nanoparticles capable of breaching the airway mucus barrier.

Author

Namho Kim, Kwak, Gijung, Rodriguez, Jason, Livraghi-Butrico, Alessandra, Xinyuan Zuo, Simon, Valentina, Han, Eric, Shenoy, Siddharth Kaup, Pandey, Nikhil, Mazur, Marina, Birket, Susan E., Kim, Anthony, Rowe, Steven M., Boucher, Richard, Hanes, Justin, Jung Soo Suk, Kim, Namho, Zuo, Xinyuan, and Suk, Jung Soo

Subjects
OBSTRUCTIVE lung disease treatment, MUCUS, DNA, LUNGS, GENE therapy, NANOPARTICLES, MICE, ANIMALS
Abstract

Introduction: Inhaled gene therapy of muco-obstructive lung diseases requires a strategy to achieve therapeutically relevant gene transfer to airway epithelium covered by particularly dehydrated and condensed mucus gel layer. Here, we introduce a synthetic DNA-loaded mucus-penetrating particle (DNA-MPP) capable of providing safe, widespread and robust transgene expression in in vivo and in vitro models of muco-obstructive lung diseases.Methods: We investigated the ability of DNA-MPP to mediate reporter and/or therapeutic transgene expression in lung airways of a transgenic mouse model of muco-obstructive lung diseases (ie, Scnn1b-Tg) and in air-liquid interface cultures of primary human bronchial epithelial cells harvested from an individual with cystic fibrosis. A plasmid designed to silence epithelial sodium channel (ENaC) hyperactivity, which causes airway surface dehydration and mucus stasis, was intratracheally administered via DNA-MPP to evaluate therapeutic effects in vivo with or without pretreatment with hypertonic saline, a clinically used mucus-rehydrating agent.Results: DNA-MPP exhibited marked greater reporter transgene expression compared with a mucus-impermeable formulation in in vivo and in vitro models of muco-obstructive lung diseases. DNA-MPP carrying ENaC-silencing plasmids provided efficient downregulation of ENaC and reduction of mucus burden in the lungs of Scnn1b-Tg mice, and synergistic impacts on both gene transfer efficacy and therapeutic effects were achieved when DNA-MPP was adjuvanted with hypertonic saline.Discussion: DNA-MPP constitutes one of the rare gene delivery systems providing therapeutically meaningful gene transfer efficacy in highly relevant in vivo and in vitro models of muco-obstructive lung diseases due to its unique ability to efficiently penetrate airway mucus. [ABSTRACT FROM AUTHOR]

Published
2022
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160. Airway Remodeling in Ferrets with Cigarette Smoke Induced COPD using µCT Imaging Supplement File

Author

Stanford, Denise, Kim, Harrison, Bodduluri, Sandeep, LaFontaine, Jennifer, Byzek, Stephen A., Schoeb, Trenton R., Elex S. Harris, Hrudaya P. Nath, Bhatt, Surya P., S. Vamsee Raju, and Rowe, Steven M.

Subjects
respiratory system
Abstract

RATIONALE: Structural changes to airway morphology such as increased bronchial wall thickness (BWT) and airway wall area are cardinal features of chronic obstructive pulmonary disease (COPD). Ferrets are a recently established animal model uniquely exhibiting similar clinical and pathological characteristics of COPD as humans, including chronic bronchitis. OBJECTIVES: Develop a µCT method for evaluating structural changes to the airways in ferrets, and assess whether the effects of smoking induce changes consistent with chronic bronchitis in humans. METHODS: Ferrets were exposed to mainstream cigarette smoke or air control twice daily for 6 months. µCT was conducted in vivo at 6 months; a longitudinal cohort was imaged monthly. Manual measurements of BWT, luminal diameter (LD), and BWT:LD ratio were conducted, and confirmed by a semi-automated algorithm. The square root of bronchial wall area (WA) vs. luminal perimeter was determined on an individual ferret basis. MEASUREMENTS AND MAIN RESULTS: Smoke exposed ferrets reproducibly demonstrated 34% increased BWT (P CONCLUSIONS: µCT-based airway measurements in ferrets are feasible and reproducible. Smoke exposed ferrets develop increased BWT and Pi4, changes similar to humans with chronic bronchitis. µCT can be used as a significant translational platform to measure dynamic airway morphological changes.

Published
2020
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161. Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial

Author

Rowe,Steven M, Jones,Ieuan, Dransfield,Mark T, Haque,Nazmul, Gleason,Stephen, Hayes,Katy A, Kulmatycki,Kenneth, Yates,Denise P, Danahay,Henry, Gosling,Martin, Rowlands,David J, Grant,Sarah S, Rowe,Steven M, Jones,Ieuan, Dransfield,Mark T, Haque,Nazmul, Gleason,Stephen, Hayes,Katy A, Kulmatycki,Kenneth, Yates,Denise P, Danahay,Henry, Gosling,Martin, Rowlands,David J, and Grant,Sarah S

Abstract

Steven M Rowe,1 Ieuan Jones,2 Mark T Dransfield,1 Nazmul Haque,2 Stephen Gleason,2 Katy A Hayes,2 Kenneth Kulmatycki,2 Denise P Yates,2 Henry Danahay,3 Martin Gosling,3,4 David J Rowlands,2 Sarah S Grant2 1University of Alabama at Birmingham, Department of Medicine, Birmingham, AL, USA; 2Novartis Institutes for BioMedical Research, Cambridge, MA, USA; 3Enterprise Therapeutics, Brighton, UK; 4Sussex Drug Discovery Centre, University of Sussex, Brighton, UKCorrespondence: Sarah S GrantNovartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA 02139, USATel +16178717812Email sarah.grant@novartis.comRationale: Excess mucus plays a key role in COPD pathogenesis. Cigarette smoke-induced cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction may contribute to disease pathogenesis by depleting airway surface liquid and reducing mucociliary transport; these defects can be corrected in vitro by potentiating CFTR.Objective: To assess the efficacy of the CFTR potentiator icenticaftor in improving airflow obstruction in COPD patients with symptoms of chronic bronchitis.Methods: In this double-blind, placebo-controlled study, COPD patients were randomized (2:1) to either icenticaftor  300 mg or placebo b.i.d. This non-confirmatory proof of concept study was powered for lung clearance index (LCI) and pre-bronchodilator FEV1, with an estimated sample size of 90 patients. The primary endpoint was change from baseline in LCI for icenticaftor versus placebo at Day 29; key secondary endpoints included change from baseline in pre- and post-bronchodilator FEV1 on Day 29. Key exploratory endpoints included change from baseline in sweat chloride, plasma fibrinogen levels, and sputum colonization.Results: Ninety-two patients were randomized (icenticaftor, n=64; placebo, n=28). At Day 29, icenticaftor showed no improvement in change in LCI (treatment difference: 0.28 [19% probability of being better than placebo]), an

Published
2020

163. Abstracts from the 23rd Italian congress of Cystic Fibrosis and the 13th National congress of Cystic Fibrosis Italian Society

Author

Bevivino, Annamaria, Coiana, Alessandra, Fogazzi, Annalisa, Timelli, Fabiana, Signorini, Sandra, Lucarelli, Marco, Morelli, Patrizia, Padoan, Rita, Giordani, Barbara, Amato, Annalisa, Majo, Fabio, Ferrari, Gianluca, Quattrucci, Serena, Minicucci, Laura, Floridia, Giovanna, Fornaro, Gianna Puppo, Taruscio, Domenica, Salvatore, Marco, Seia, Manuela, Pierandrei, Silvia, Blaconà, Giovanna, Salvati, Valentina, Sette, Giovanni, Cimino, Giuseppe, Sangiuolo, Federica, Eramo, Adriana, Collura, Mirella, Parisi, Elisa, Ferlisi, Annalisa, Traverso, Gabriella, Bertolino, Marcella, Termini, Lisa, Orlando, Maria A., Di Girgenti, Caterina, Pavone, Valeria, Calamia, Maria A., Silvestro, Maria G., Piparo, Caterina Lo, Ficili, Francesca, Colombo, Carla, Tullis, Elizabeth, Davies, Jane C., Mckee, Charlotte, Desouza, Cynthia, Waltz, David, Savage, Jessica, Fisher, Marc, Shilling, Rebecca, Moskowitz, Sam, Robertson, Sarah, Tian, Simon, Taylor-Cousar, Jennifer L., Rowe, Steven M., Beccia, Elisa, Carbone, Annalucia, Favia, Maria, Castellani, Stefano, Angiolillo, Antonella, Casavola, Valeria, Conese, Massimo, Cesana, Bruno M., Falchetti, Diego, Battistini, Fiorella, Bignamini, Elisabetta, Braggion, Cesare, Cirilli, Natalia, Lucanto, Maria C., Lucidi, Vincenzina, Manca, Antonio, Raia, Valeria, Rotolo, Novella, Salvatore, Donatello, Volpi, Sonia, Nazzari, Erica, Guarise, Riccardo, Mileto, Palmiro, Garbarino, Francesca, Alicandro, Gianfranco, Battezzati, Alberto, Di Lullo, Antonella M., Comegna, Marika, Amato, Felice, Iacotucci, Paola, Carnovale, Vincenzo, Cantone, Elena, Iengo, Maurizio, Castaldo, Giuseppe, Orlando, Claudio, Casale, Alida, Sepe, Angela, De Gregorio, Fabiola, De Matteo, Antonia, Castaldo, Alice, Cimbalo, Chiara, Tosco, Antonella, Savi, Daniela, Mordenti, Michela, Bonci, Enea, Troiani, Patrizia, D’Alù, Viviana, Rossi, Paolo, Varchetta, Monica, Perelli, Tamara, Bertasi, Serenella, Palange, Paolo, Tardino, Lucia, Parisi, Giuseppe F., Portale, Anna, Franzonello, Chiara, Papale, Maria, Leonardi, Salvatore, Pennisi, Francesca, Bruno, Sabina M., Licciardello, Giulia, Ferraguti, Giampiero, Sterrantino, Manuela, Testino, Giancarlo, Buzzetti, Roberto, Surace, Cecilia, Sofia, Valentina M., Ullmann, Nicola, Novelli, Antonio, Angioni, Adriano, Liguori, Renato, Manzoni, Francesca, Di Palma, Chiara, Maietta, Sabrina, Zarrilli, Federica, Terlizzi, Vito, Alghisi, Federico, Tuccio, Giuseppe, Tradati, Valentina, di Stefano, Eliana, Dato, Patrizia, Sciarrabone, Maria G., Fondacaro, Carmela, Cresta, Federico, Baglioni, Valentina, Garuti, Silvia, Buffoni, Isabella, Landi, Francesca, Casciaro, Rosaria, Girelli, Daniela, Teri, Antonio, Sottotetti, Samantha, Biffi, Arianna, Vignati, Chiara, D’Accico, Monica, Maraschini, Anna, Arghittu, Milena, Pizzamiglio, Giovanna, Cariani, Elisa, Dolce, Daniela, Ravenni, Novella, Campana, Silvia, Camera, Erica, Castellani, Carlo, Taccetti, Giovanni, Calderone, Eleonora, Bandettini, Roberto, Innocenti, Chiara Degli, Castellani, Chiara, Masi, Eleonora, Cavicchi, Maria Chiara, Ferrari, Beatrice, Pezzotta, Ramona, Poli, Piercarlo, Messali, Serena, Timpano, Silvana, Scaltriti, Erika, Pongolini, Stefano, Fiorentini, Simona, Bresci, Silvia, Corsi, Lorenzo, Borchi, Beatrice, Cavallo, Annalisa, Bartalesi, Filippo, Pistolesi, Massimo, Bartoloni, Alessandro, Arcoleo, Federica, Pensabene, Tiziana, Bacci, Giovanni, Armanini, Federica, Fiscarelli, Ersilia V., Segata, Nicola, Mengoni, Alessio, Di Toppa, Maria V., Popa, Nicoleta, Felicetti, Francesco, Graziano, Sonia, Ciprandi, Riccardo, Pescini, Rita, Graffigna, Guendalina, Barello, Serena, Catastini, Paola, De Masi, Salvatore, Braggion, C., Guarnuto, Lucia, Di Liberti, Emanuela, Patti, Valentina, Castellazzi, Massimo Luca, Daccò, Valeria, Claut, Laura, Giuliari, Matteo, Vicentini, Luana, Tilotta, Fausto, Paciaroni, Antonella, Sala, Sabino Della, Guerzoni, Cristina, Andreatta, Elisa, Dinnella, Grazia, Granata, Orazia M., Aronica, Tommaso S., Crapisi, Mimì, Fogazza, Donatella, Alessi, Luca, Mulè, Flavia, Vitaliti, Marcello, Maresi, Mariarosaria, Catzola, Andrea, Salvadori, Laura, Colangelo, Carmela, Marsicovetere, Giovanni, D’Andria, Michele, Passarella, Domenica, Genovese, Carmela, Orlando, Mari A., Barrale, Stefania, Bonaccorso, Maria R., and D’Arpa, Annalisa

Subjects
lcsh:RJ1-570, lcsh:Pediatrics, Meeting Abstracts
Published
2018

164. Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849+10kb C-to-T splicing mutation

Author

Oren, Yifat S., primary, Sinai, Michal Irony-Tur, additional, Golec, Anita, additional, Barchad-Avitzur, Ofra, additional, Mutyam, Venkateshwar, additional, Li, Yao, additional, Hong, Jeong, additional, Ozeri-Galai, Efrat, additional, Hatton, Aurélie, additional, Reiter, Joel, additional, Sorscher, Eric J., additional, Wilton, Steve D., additional, Kerem, Eitan, additional, Rowe, Steven M., additional, Sermet-Gaudelus, Isabelle, additional, and Kerem, Batsheva, additional

Published
2021
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165. Clinical Effectiveness of Lumacaftor/Ivacaftor in Patients with Cystic Fibrosis Homozygous for F508del-CFTR. A Clinical Trial

Author

Sagel, Scott D., primary, Khan, Umer, additional, Heltshe, Sonya L., additional, Clancy, John P., additional, Borowitz, Drucy, additional, Gelfond, Daniel, additional, Donaldson, Scott H., additional, Moran, Antoinette, additional, Ratjen, Felix, additional, VanDalfsen, Jill M., additional, and Rowe, Steven M., additional

Published
2021
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167. Mechanisms of disease: Cystic fibrosis

Author

Rowe, Steven M., Miller, Stacey, and Sorscher, Eric J.

Subjects
Cystic fibrosis -- Research
Abstract

Details regarding the mechanisms, such as the sequelae stemming from the absence of a functioning cystic fibrosis transmembrane conductance regulator (CFTR), and the therapeutic strategies devised to cure cystic fibrosis were mentioned. Progress in research in cystic fibrosis will continue to rely on an improved understanding of CFTR function and its relationship to mucociliary clearance, airway secretion and other ion channels.

Published
2005

168. A simple test could extend cystic-fibrosis treatments to those left behind

Author

Rowe, Steven M.

Subjects
Gene mutations -- Statistics -- Laws, regulations and rules, Cystic fibrosis -- Drug therapy -- Testing, Ivacaftor -- Laws, regulations and rules -- Dosage and administration -- Testing, Government regulation, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Sweat-chloride measurements could be used to develop and approve drugs for rare mutations in cystic fibrosis. Sweat-chloride measurements could be used to develop and approve drugs for rare mutations in cystic fibrosis., Author(s): Steven M. Rowe Author Affiliations: A simple test could extend cystic-fibrosis treatments to those left behind The advent of highly efficacious therapies against cystic fibrosis is a stunning achievement. [...]

Published
2020
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179. Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation

Author

Clancy, J P, Rowe, Steven M, Accurso, Frank J, Aitken, Moira L, Amin, Raouf S, Ashlock, Melissa A, Ballmann, Manfred, Boyle, Michael P, Bronsveld, Inez, Campbell, Preston W, De Boeck, Kris, Donaldson, Scott H, Dorkin, Henry L, Dunitz, Jordan M, Durie, Peter R, Jain, Manu, Leonard, Anissa, McCoy, Karen S, Moss, Richard B, Pilewski, Joseph M, Rosenbluth, Daniel B, Rubenstein, Ronald C, Schechter, Michael S, Botfield, Martyn, Ordoñez, Claudia L, Spencer-Green, George T, Vernillet, Laurent, Wisseh, Steve, Yen, Karl, and Konstan, Michael W

Published
2012
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180. Colaboradores

Author

Adams, Lewis, Adamson, Rosemary, Adler, Dan E., Akoumianaki, Evangelia, Albert, Tyler J., Albertine, Kurt H., Alexander, Barbara D., Amos, Christopher I., Arenberg, Douglas A., Argento, A. Christine, Atif, Shaikh M., Ayas, Najib T., Babik, Jennifer M., Badlam, Jessica B., Balmes, John Randolph, Banaei, Niaz, Barnett, Christopher F., Bartolome, Sonja D., Baughman, Robert P., Beers, Michael F., Benditt, Joshua O., Benowitz, Neal L., Bhakta, Nirav R., Bhatnagar, Rahul, Bhatt, Surya P., Bibby, Anna C., Binnie, Alexandra, Blanc, Paul D., Borok, Zea, Bradley, T. Douglas, Broaddus, V. Courtney, Brochard, Laurent J., Brody, Steven L., Brown, Kevin K., Brunetta, Paul G., Cadranel, Jacques, Carr, Shamus R., Carr, Tara F., Cattamanchi, Adithya, Chalabreysse, Lara, Chan, Edward D., Chan, Ken K.P., Chastre, Jean, Cheng, Guang-Shing, Chin, Kelly M., Cho, Michael H., Christiani, David C., Chung, Kian Fan, Clive, Amelia O., Cohen, Robert A., Colby, Thomas V., Cool, Carlyne D., Cordioli, Ricardo Luiz, Corte, Tamera J., Cottin, Vincent, Crothers, Kristina, Curtis, Jeffrey L., Daley, Charles L., Davidson, Bruce L., Davies, Helen E., Davis, J. Lucian, De Marco, Teresa, Deresinski, Stanley C., Deroose, Christophe M., Dixon, Anne E., Dockrell, David H., Dooms, Christophe, Downey, Gregory P., DuBrock, Hilary, El-Chemaly, Souheil, Elliott, C. Gregory, Ernst, Joel D., Evans, Christopher M., Fahy, John V., Fajardo, Elaine, Fan, Eddy, Faughnan, Marie E., Feller-Kopman, David, Fenster, Brett E., Fernandes, Timothy M., Fernández Pérez, Evans R., Fischer, William A., II, Fontenot, Andrew P., Frank, James, Frankel, Stephen K., Friedberg, Joseph, Fung, Monica, Gao, Yuansheng, Garpestad, Erik, Gartman, Eric J., Gebhart, G.F., George, Gautam, Gesthalter, Yaron B., Gladwin, Mark T., Go, Leonard H.T., Gidwani, Nisha H., Girard, Nicolas, Glenny, Robb W., Goligher, Ewan C., Gomez, Antonio, Gonzalez, Anne V., Gordon, Stephen B., Gossot, Dominique, Gotts, Jeffrey E., Gotway, Michael B., Gould, Michael, Graney, Bridget A., Grasselli, Giacomo, Greenland, John R., Griffith, David E., Gupta, Nishant, Hallifax, Rob, Han, Meilan K., Hansel, Nadia N., Hatipoğlu, Umur, Henderson, William R., Herold, Susanne, Herridge, Margaret S., Hiensch, Robert, Hilbert, Janet, Hill, Nicholas S., Ho, Antonia, Holm, Stephanie M., Hoover, Wynton, Hopewell, Philip C., Horne, David J., Horner, Richard L., Hsia, Connie C.W., Huang, Laurence, Huddleston, Lindsey L., Hyzy, Robert C., Inoue, Yoshikazu, Jakubzick, Claudia V., Jia, Shijing, Johannson, Kerri A., Johnson, Meshell, Jokerst, Clinton E., Jones, Kirk D., Judson, Marc A., Kalil, Andre C., Kaminska, Marta, Kaminsky, David A., Kato-Maeda, Midori, Kaufman, David A., Kerr, Kim M., Keshavjee, Shaf, Kheir, Fayez, Kidson, Kristen M., Kim, Kami, Kim, Suil, Kimoff, R. John, King, Talmadge E., Jr., Kitsios, Georgios, Klein, Jeffrey S., Konopka, Kristine, Koth, Laura L., Kotloff, Robert M., Kraft, Monica, Krishnan, Vidya, Kroon, Lisa, Kuebler, Wolfgang M., Küpeli, Elif, Kuschner, Ware G., Lambrecht, Bart N., Lammi, Matthew R., Lapinsky, Stephen E., Lazarus, Stephen C., Lee, Jarone, Lee, Joyce S., Lee, Warren L., Lee, Won Y., Lee, Y. C. Gary, Lee-Chiong, Teofilo L., Jr., Lehman, Jonathan M., Lemière, Catherine, Lentz, Robert J., Light, Richard W., Limper, Andrew H., Lipnick, Michael S., Liu, Stanley Yung-Chuan, Loyd, James E., Lugogo, Njira, Luks, Andrew M., Lurie, Nicole, Luyt, Charles-Edouard, Lyon, Stuart M., Machado, Roberto F., Maier, Lisa A., Malhotra, Atul, Martin, Thomas R., Maskell, Nick A., Massion, Pierre P., Mathai, Stephen C., Matson, Scott M., Matthay, Michael A., Matthay, Richard A., May, Anna M., Mayer, Annyce S., Mazzone, Peter J., Mazzone, Stuart B., McCarthy, Cormac, McCool, F. Dennis, McCormack, Francis X., McCormack, Meredith C., McCulley, David, McVerry, Bryan J., Mehra, Reena, Mehta, Atul C., Metersky, Mark L., Meyer, Nuala J., Mira-Avendano, Isabel C., Mody, Gita N., Mokhlesi, Babak, Morris, Alison, Morris, Amy E., Morris, Timothy A., Morty, Rory E., Mudambi, Lakshmi, Munger, John S., Munavvar, Mohammed, Nahid, Payam, Nelson-Piercy, Catherine, Nici, Linda, Nishimura, Stephen L., Nosanchuk, Joshua D., O’Riordan, Thomas G., Ortega, Victor Enrique, Ortiz, Justin R., Pamidi, Sushmita, Pastis, Nicholas J., Patel, Sanjay R., Patroniti, Nicolò, Pergam, Steven A., Pesenti, Antonio, Peters, Michael C., Pfeifer, Kurt, Philips, Jennifer A., Pinsky, Benjamin A., Pletcher, Steven D., Prabhudesai, Vikramaditya, Que, Loretta G., Quick, Bryon D., Rahman, Najib M., Raj, J. Usha, Ramirez, Maria I., Reddy, Rishindra M., Redente, Elizabeth F., Reed, Hasina Outtz, Reinhardt, R. Lee, Riches, David W.H., Rivera, M. Patricia, Rochester, Carolyn L., Roman, Jesse, Rose, Alexandra, Rosen, Clark A., Routes, John M., Rowe, Steven M., Ryan, Clodagh M., Ryu, Jay H., Sanghavi, Sarah, Sarmiento, Kathleen F., Saullo, Jennifer L., Schoene, Robert B., Schumaker, Gregory L., Schwartz, David A., Schwartzstein, Richard M., Schwarz, Marvin I., Selman, Moisés, Shah, Neomi, Shah, Rupal J., Shete, Priya B., Shojaee, Samira, Silvestri, Gerard A., Singer, Jonathan P., Slatore, Christopher G., Smaldone, Gerald C., Smetana, Gerald W., Solomon, George M., Sorscher, Eric J., Stapleton, Renee D., Sterman, Daniel, Stewart, Shelby J., Stoller, James K., Sun, Xin, Sunwoo, Bernie Y., Sweeney, Daniel A., Swenson, Erik R., Tanner, Nichole T., Tanoue, Lynn, Thompson, George R., III, Trapnell, Bruce C., Triplette, Matthew, Tukey, Melissa H., Tzelepis, George E., Urisman, Anatoly, Vandenplas, Olivier, Van Hoesen, Karen B., Varghese, Thomas K., Jr., Vassallo, Robert, Verbsky, James W., Wagh, Ajay, Walsh, Ryan, Weber, David J., Weiner, Ashley A., Weiss, Louis M., Wells, Athol U., West, John B., West, T. Eoin, White, Douglas B., Winthrop, Kevin L., Wohl, David A., Wolfe, Lisa F., Woodruff, Prescott G., Worodria, William, Yeh, D. Dante, Yoon, Christina, Young, VyVy N., Zacharias, William J., and Zanella, Alberto

Published
2023
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181. A CFTR Potentiator in Patients with Cystic Fibrosis and the G551D Mutation

Author

Ramsey, Bonnie W., Davies, Jane, McElvaney, Gerard N., Tullis, Elizabeth, Bell, Scott C., Dřevínek, Pavel, Griese, Matthias, McKone, Edward F., Wainwright, Claire E., Konstan, Michael W., Moss, Richard, Ratjen, Felix, Sermet-Gaudelus, Isabelle, Rowe, Steven M., Dong, Qunming, Rodriguez, Sally, Yen, Karl, Ordoñez, Claudia, and Elborn, Stuart J.

Published
2011
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184. Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR

Author

Birket, Susan E., primary, Davis, Joy M., additional, Fernandez-Petty, Courtney M., additional, Henderson, Alexander G., additional, Oden, Ashley M., additional, Tang, LiPing, additional, Wen, Hui, additional, Hong, Jeong, additional, Fu, Lianwu, additional, Chambers, Andre, additional, Fields, Alvin, additional, Zhao, Gojun, additional, Tearney, Guillermo J., additional, Sorscher, Eric J., additional, and Rowe, Steven M., additional

Published
2020
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186. Novel Therapy of Bicarbonate, Glutathione, and Ascorbic Acid Improves Cystic Fibrosis Mucus Transport

Author

Adewale, Adegboyega Timothy, primary, Falk Libby, Emily, additional, Fu, Lianwu, additional, Lenzie, Andrew, additional, Boitet, Evan R., additional, Birket, Susan E., additional, Petty, Courtney Fernandez, additional, Johns, J. Dixon, additional, Mazur, Marina, additional, Tearney, Guillermo J., additional, Copeland, Dan, additional, Durham, Carolyn, additional, and Rowe, Steven M., additional

Published
2020
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187. Contribution of Short Chain Fatty Acids to the Growth of Pseudomonas aeruginosa in Rhinosinusitis

Author

Cho, Do-Yeon, primary, Skinner, Daniel, additional, Hunter, Ryan C., additional, Weeks, Christopher, additional, Lim, Dong Jin, additional, Thompson, Harrison, additional, Walz, Christopher R., additional, Zhang, Shaoyan, additional, Grayson, Jessica W., additional, Swords, William E., additional, Rowe, Steven M., additional, and Woodworth, Bradford A., additional

Published
2020
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188. Fibroblast Growth Factor Receptor 4 Deficiency Mediates Airway Inflammation in the Adult Healthy Lung?

Author

Easter, Molly, primary, Garth, Jaleesa, additional, Harris, Elex S., additional, Shei, Ren-Jay, additional, Helton, Eric S., additional, Wei, Yuhua, additional, Denson, Rebecca, additional, Zaharias, Rennan, additional, Rowe, Steven M., additional, Geraghty, Patrick, additional, Faul, Christian, additional, Barnes, Jarrod W., additional, and Krick, Stefanie, additional

Published
2020
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197. Disease modification and biomarker development in Parkinson disease

Author

Espay, Alberto J., primary, Kalia, Lorraine V., additional, Gan-Or, Ziv, additional, Williams-Gray, Caroline H., additional, Bedard, Philippe L., additional, Rowe, Steven M., additional, Morgante, Francesca, additional, Fasano, Alfonso, additional, Stecher, Benjamin, additional, Kauffman, Marcelo A., additional, Farrer, Matthew J., additional, Coffey, Chris S., additional, Schwarzschild, Michael A., additional, Sherer, Todd, additional, Postuma, Ronald B., additional, Strafella, Antonio P., additional, Singleton, Andrew B., additional, Barker, Roger A., additional, Kieburtz, Karl, additional, Olanow, C. Warren, additional, Lozano, Andres, additional, Kordower, Jeffrey H., additional, Cedarbaum, Jesse M., additional, Brundin, Patrik, additional, Standaert, David G., additional, and Lang, Anthony E., additional

Published
2020
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200. The Effects of the Anti-aging Protein Klotho on Mucociliary Clearance

Author

Garth, Jaleesa, primary, Easter, Molly, additional, Skylar Harris, Elex, additional, Sailland, Juliette, additional, Kuenzi, Lisa, additional, Chung, Samuel, additional, Dennis, John S., additional, Baumlin, Nathalie, additional, Adewale, Adegboyega T., additional, Rowe, Steven M., additional, King, Gwendalyn, additional, Faul, Christian, additional, Barnes, Jarrod W., additional, Salathe, Matthias, additional, and Krick, Stefanie, additional

Published
2020
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