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2,924 results on '"Rothwell, Peter"'

151. The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial.

Author

Kopczak, Anna, S Stringer, Michael, van den Brink, Hilde, Kerkhofs, Danielle, W Blair, Gordon, van Dinther, Maud, Onkenhout, Laurien, A Wartolowska, Karolina, Thrippleton, Michael J, Duering, Marco, Staals, Julie, Middeke, Martin, André, Elisabeth, Norrving, Bo, Bousser, Marie-Germaine, Mansmann, Ulrich, Rothwell, Peter M, N Doubal, Fergus, van Oostenbrugge, Robert, and Jan Biessels, Geert

Published
2023
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152. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies

Author

Traylor, Matthew, Farrall, Martin, Holliday, Elizabeth G, Sudlow, Cathie, Hopewell, Jemma C, Cheng, Yu-Ching, Fornage, Myriam, Ikram, M Arfan, Malik, Rainer, Bevan, Steve, Thorsteinsdottir, Unnur, Nalls, Mike A, Longstreth, WT, Wiggins, Kerri L, Yadav, Sunaina, Parati, Eugenio A, DeStefano, Anita L, Worrall, Bradford B, Kittner, Steven J, Khan, Muhammad Saleem, Reiner, Alex P, Helgadottir, Anna, Achterberg, Sefanja, Fernandez-Cadenas, Israel, Abboud, Sherine, Schmidt, Reinhold, Walters, Matthew, Chen, Wei-Min, Ringelstein, E Bernd, O'Donnell, Martin, Ho, Weang Kee, Pera, Joanna, Lemmens, Robin, Norrving, Bo, Higgins, Peter, Benn, Marianne, Sale, Michele, Kuhlenbäumer, Gregor, Doney, Alexander S F, Vicente, Astrid M, Delavaran, Hossein, Algra, Ale, Davies, Gail, Oliveira, Sofia A, Palmer, Colin N A, Deary, Ian, Schmidt, Helena, Pandolfo, Massimo, Montaner, Joan, Carty, Cara, de Bakker, Paul I W, Kostulas, Konstantinos, Ferro, Jose M, van Zuydam, Natalie R, Valdimarsson, Einar, Nordestgaard, Børge G, Lindgren, Arne, Thijs, Vincent, Slowik, Agnieszka, Saleheen, Danish, Paré, Guillaume, Berger, Klaus, Thorleifsson, Gudmar, Hofman, Albert, Mosley, Thomas H, Mitchell, Braxton D, Furie, Karen, Clarke, Robert, Levi, Christopher, Seshadri, Sudha, Gschwendtner, Andreas, Boncoraglio, Giorgio B, Sharma, Pankaj, Bis, Joshua C, Gretarsdottir, Solveig, Psaty, Bruce M, Rothwell, Peter M, Rosand, Jonathan, Meschia, James F, Stefansson, Kari, Dichgans, Martin, and Markus, Hugh S

Published
2012
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160. Heteroplasmic mitochondrial DNA variants in cardiovascular diseases

Author

Calabrese, Claudia, primary, Pyle, Angela, additional, Griffin, Helen, additional, Coxhead, Jonathan, additional, Hussain, Rafiqul, additional, Braund, Peter S, additional, Li, Linxin, additional, Burgess, Annette, additional, Munroe, Patricia B, additional, Little, Louis, additional, Warren, Helen R, additional, Cabrera, Claudia, additional, Hall, Alistair, additional, Caulfield, Mark J, additional, Rothwell, Peter M, additional, Samani, Nilesh J, additional, Hudson, Gavin, additional, and Chinnery, Patrick F., additional

Published
2022
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163. Prognosis of Cryptogenic Stroke With Patent Foramen Ovale at Older Ages and Implications for Trials

Author

Mazzucco, Sara, Li, Linxin, and Rothwell, Peter M.

Subjects
Clinical Trials as Topic, Observational Studies as Topic, stomatognathic system, Research, Population Surveillance, Age Factors, Online First, Foramen Ovale, Patent, Humans, Prognosis, Comments, Original Investigation, Ischemic Stroke
Abstract

Key Points Question Is the prognosis of cryptogenic transient ischemic attack and stroke in patients receiving medical treatment alone associated with the presence of patent foramen ovale and age? Findings In this population-based study, risk of recurrent ischemic stroke (2.05 per 100 patient-years) was consistent with the pooled estimate from a systematic review and meta-analysis (2 per 100 patient-years). Risk increased with mean cohort age, and only in patients with cryptogenic transient ischemic attack and stroke aged 65 years or older was patent foramen ovale vs no patent foramen ovale associated with a higher risk of recurrent ischemic stroke. Meaning The findings of this study suggest that a higher risk of stroke recurrence at older ages in patients with patent foramen ovale warrants trials of patent foramen ovale closure in older patients., Importance Patent foramen ovale (PFO) closure may prevent recurrent stroke after cryptogenic transient ischemic attack (TIA) or stroke (TIA/stroke) in patients aged 60 years or younger. Patent foramen ovale is associated with cryptogenic stroke in the older population, but risk of recurrence is unknown. Data on prognosis of patients receiving medical treatment at older ages (≥60 years) are essential to justify trials of PFO closure. Objective To examine the age-specific risk of recurrence in patients with cryptogenic TIA/stroke with PFO. Design, Setting, and Participants A prospective study was nested in the population-based Oxford Vascular Study between September 1, 2014, and March 31, 2019, with face-to-face follow-up for 5 years. A total of 416 consecutive patients with a diagnosis of cryptogenic TIA or nondisabling stroke, screened for PFO at a rapid-access TIA/stroke clinic, were included. A systematic review and meta-analysis of cohort studies reporting on ischemic stroke recurrence after cryptogenic TIA/stroke in patients with PFO who were receiving medical therapy alone, or with PFO vs no-PFO was conducted. Sample size calculation for future trials on PFO closure was performed for patients aged 60 years or older. Exposures Patent foramen ovale and age as modifiers of risk of recurrent stroke after cryptogenic TIA/stroke in patients receiving only medical therapy. Main Outcomes and Measures Risk of ischemic stroke recurrence in patients with cryptogenic TIA/stroke and PFO receiving medical therapy only, and in patients with vs without PFO, stratified by age (, This systematic review and meta-analysis examines the recurrence of ischemic stroke and possible use of patent foramen ovale closure in patients aged 60 years or older.

Published
2020

164. Sex-specific Genome Wide Association Study Of Early-onset Ischemic Stroke

Author

Tomppo, Liisa, Rannikmae, Kristiina, Stanne, Tara M., Putaala, Jukka, Strbian, Daniel, Jern, Christina, de Leeuw, Frank Erik, Cadenas, Israel Fernandez, Slowik, Agnieszka M., Boncoraglio, Giorgio, Lindgren, Arne, Conde, Jordi J., Schmidt, Reinhold, Sharma, Pankaj, Lemmens, Robin, Melander, Olle, Rothwell, Peter, Levi, Christopher, Sudlow, Catherine, Debette, Stephanie, Metso, Tiina, Pare, Guillaume, Markus, Hugh, Saleheen, Danish, Danesh, John, Zand, Ramin, Worrall, Bradford B., Meschia, James F., Rundek, Tatjana, Woo, Daniel, Lee, Jin Moo, Irvin, Marguerite R., Mcdonough, Caitrin W., Rexrode, Kathryn M., Wassertheil-Smoller, Sylvia W., Rosand, Jonathan, Gieger, Christian, Muller-Nurasyid, Martina, Salomaa, Veikko V., Kamatani, Yoichiro, Walters, Robin, Chen, Zhengming, Dichgans, Martin, Malik, Rainer, Gaynor, Brady, Cole, John, Xu, Huichun, Mitchell, Braxton D., Kittner, Steven J., Early-Onset Stroke, Consortium, Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Ischemic stroke, Gender differences, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Genome-wide association studies (GWAS)
Abstract

Introduction: Genetic studies of early-onset disease have been an effective strategy to identify novel pathways and drug targets generalizable also to later-onset disease. Few studies have investigated the sex-specific genetic associations with early-onset ischemic stroke even though several features of ischemic stroke differ between males and females. We hypothesized that stratifying the GWAS by sex would reveal novel stroke loci. Methods: We performed a transethnic ischemic stroke GWAS of 3,056 female cases and 4,462 male cases < 60 years-old and 16,192 and 16,048 sex-matched controls, respectively, from the Early Onset Stroke Genetics Consortium. Results: We identified a significant association in women with a locus in close proximity to TMX1, a transmembrane platelet protein that inhibits platelet function. Additionally, we identified 2 other suggestive (P < 5 x 10-6) loci in females (see Table), i.e., at APOH, which encodes beta2-glycoprotein I, an established GWAS locus for lipoprotein(a), and LRFN2 which has been previously reported to associate with obesity-related measures and type II diabetes. We observed suggestive evidence for association in males with MMP3/MMP12, a known stroke susceptibility locus. Conclusions: Despite a very modest sample size, sex-specific analyses identified suggestive associations at biologically important novel loci in females and a known stroke locus in males. Further studies of sex-specific associations in both early- and later-onset ischemic stroke are needed.

Published
2022

165. sj-docx-1-wso-10.1177_17474930221124412 – Supplemental material for Monitoring for atrial fibrillation prior to patent foramen ovale closure after cryptogenic stroke

Author

Diener, Hans-Christoph, Wachter, Rolf, Wong, Andrew, Thijs, Vincent, Schnabel, Renate B, Ntaios, George, Kasner, Scott, Rothwell, Peter M, Passman, Rod, Saver, Jeffrey L, Albers, Bert A, and Bernstein, Richard A

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930221124412 for Monitoring for atrial fibrillation prior to patent foramen ovale closure after cryptogenic stroke by Hans-Christoph Diener, Rolf Wachter, Andrew Wong, Vincent Thijs, Renate B Schnabel, George Ntaios, Scott Kasner, Peter M Rothwell, Rod Passman, Jeffrey L Saver, Bert A Albers and Richard A Bernstein in International Journal of Stroke

Published
2022
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166. sj-docx-1-wso-10.1177_17474930211068655 ��� Supplemental material for Cerebral hemodynamic effects of early blood pressure lowering after TIA and stroke in patients with carotid stenosis

Author

Mazzucco, Sara, Li, Linxin, McGurgan, Iain J, Tuna, Maria Assuncao, Brunelli, Nicoletta, Binney, Lucy E, and Rothwell, Peter M

Subjects
FOS: Clinical medicine, Cardiology, Medicine, cardiovascular diseases, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930211068655 for Cerebral hemodynamic effects of early blood pressure lowering after TIA and stroke in patients with carotid stenosis by Sara Mazzucco, Linxin Li, Iain J McGurgan, Maria Assuncao Tuna, Nicoletta Brunelli, Lucy E Binney and Peter M Rothwell in International Journal of Stroke

Published
2022
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167. sj-docx-1-wso-10.1177_17474930221123175 – Supplemental material for Global stroke statistics 2022

Author

Thayabaranathan, Tharshanah, Kim, Joosup, Cadilhac, Dominique A, Thrift, Amanda G, Donnan, Geoffrey A, Howard, George, Howard, Virginia J, Rothwell, Peter M, Feigin, Valery, Norrving, Bo, Owolabi, Mayowa, Pandian, Jeyaraj, Liu, Liping, and Olaiya, Muideen T

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-wso-10.1177_17474930221123175 for Global stroke statistics 2022 by Tharshanah Thayabaranathan, Joosup Kim, Dominique A Cadilhac, Amanda G Thrift, Geoffrey A Donnan, George Howard, Virginia J Howard, Peter M Rothwell, Valery Feigin, Bo Norrving, Mayowa Owolabi, Jeyaraj Pandian, Liping Liu and Muideen T Olaiya in International Journal of Stroke

Published
2022
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168. sj-docx-1-eso-10.1177_23969873221143570 – Supplemental material for The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial

Author

Kopczak, Anna, S Stringer, Michael, van den Brink, Hilde, Kerkhofs, Danielle, W Blair, Gordon, van Dinther, Maud, Onkenhout, Laurien, A Wartolowska, Karolina, Thrippleton, Michael J, Duering, Marco, Staals, Julie, Middeke, Martin, André, Elisabeth, Norrving, Bo, Bousser, Marie-Germaine, Mansmann, Ulrich, Rothwell, Peter M, N Doubal, Fergus, van Oostenbrugge, Robert, Jan Biessels, Geert, Webb, Alastair JS, Wardlaw, Joanna M, and Dichgans, Martin

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873221143570 for The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial by Anna Kopczak, Michael S Stringer, Hilde van den Brink, Danielle Kerkhofs, Gordon W Blair, Maud van Dinther, Laurien Onkenhout, Karolina A Wartolowska, Michael J Thrippleton, Marco Duering, Julie Staals, Martin Middeke, Elisabeth André, Bo Norrving, Marie-Germaine Bousser, Ulrich Mansmann, Peter M Rothwell, Fergus N Doubal, Robert van Oostenbrugge, Geert Jan Biessels, Alastair JS Webb, Joanna M Wardlaw and Martin Dichgans in European Stroke Journal

Published
2022
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180. Automated Detection of Candidate Subjects With Cerebral Microbleeds Using Machine Learning

Author

Sundaresan, Vaanathi, primary, Arthofer, Christoph, additional, Zamboni, Giovanna, additional, Dineen, Robert A., additional, Rothwell, Peter M., additional, Sotiropoulos, Stamatios N., additional, Auer, Dorothee P., additional, Tozer, Daniel J., additional, Markus, Hugh S., additional, Miller, Karla L., additional, Dragonu, Iulius, additional, Sprigg, Nikola, additional, Alfaro-Almagro, Fidel, additional, Jenkinson, Mark, additional, and Griffanti, Ludovica, additional

Published
2022
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184. One-Year Risk of Stroke After Transient Ischemic Attack or Minor Stroke in Hunter New England, Australia (INSIST Study)

Author

Tomari, Shinya, primary, Levi, Christopher R., additional, Holliday, Elizabeth, additional, Lasserson, Daniel, additional, Valderas, Jose M., additional, Dewey, Helen M., additional, Barber, P. Alan, additional, Spratt, Neil J., additional, Cadilhac, Dominique A., additional, Feigin, Valery L., additional, Rothwell, Peter M., additional, Zareie, Hossein, additional, Garcia-Esperon, Carlos, additional, Davey, Andrew, additional, Najib, Nashwa, additional, Sales, Milton, additional, and Magin, Parker, additional

Published
2021
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187. Atherogenic Dyslipidemia and Residual Cardiovascular Risk in Statin-Treated Patients

Author

Sirimarco, Gaia, Labreuche, Julien, Bruckert, Eric, Goldstein, Larry B., Fox, Kim M., Rothwell, Peter M., Amarenco, Pierre, Bousser, Marie-Germaine, Chamorro, Angel, Ford, Ian, Fox, Kim, Fisher, Marc, Hennerici, Michael G., Mattle, Heinrich, Rothwell, Peter M., Callahan, Fred, III, Goldstein, Larry B., Sillesen, Henrik, Welch, K. Michael A., and Zivin, Justin A.

Published
2014
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193. One-Year Risk of Stroke after Transient Ischemic Attack or Minor Stroke

Author

Amarenco, Pierre, Lavallée, Philippa C., Labreuche, Julien, Albers, Gregory W., Bornstein, Natan M., Canhão, Patrícia, Caplan, Louis R., Donnan, Geoffrey A., Ferro, José M., Hennerici, Michael G., Molina, Carlos, Rothwell, Peter M., Sissani, Leila, Školoudík, David, Steg, Philippe Gabriel, Touboul, Pierre-Jean, Uchiyama, Shinichiro, Vicaut, Éric, and Wong, Lawrence K.S.

Published
2016
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196. Genome-Wide Association Analysis of Young-Onset Stroke Identifies a Locus on Chromosome 10q25 Near HABP2

Author

Cheng, Yu-Ching, Stanne, Tara M., Giese, Anne-Katrin, Ho, Weang Kee, Traylor, Matthew, Amouyel, Philippe, Holliday, Elizabeth G., Malik, Rainer, Xu, Huichun, Kittner, Steven J., Cole, John W., O’Connell, Jeffrey R., Danesh, John, Rasheed, Asif, Zhao, Wei, Engelter, Stefan, Grond-Ginsbach, Caspar, Kamatani, Yoichiro, Lathrop, Mark, Leys, Didier, Thijs, Vincent, Metso, Tiina M., Tatlisumak, Turgut, Pezzini, Alessandro, Parati, Eugenio A., Norrving, Bo, Bevan, Steve, Rothwell, Peter M., Sudlow, Cathie, Slowik, Agnieszka, Lindgren, Arne, Walters, Matthew R., Jannes, Jim, Shen, Jess, Crosslin, David, Doheny, Kimberly, Laurie, Cathy C., Kanse, Sandip M., Bis, Joshua C., Fornage, Myriam, Mosley, Thomas H., Hopewell, Jemma C., Strauch, Konstantin, Müller-Nurasyid, Martina, Gieger, Christian, Waldenberger, Melanie, Peters, Annette, Meisinger, Christine, Ikram, M. Arfan, Longstreth, W.T., Jr, Meschia, James F., Seshadri, Sudha, Sharma, Pankaj, Worrall, Bradford, Jern, Christina, Levi, Christopher, Dichgans, Martin, Boncoraglio, Giorgio B., Markus, Hugh S., Debette, Stephanie, Rolfs, Arndt, Saleheen, Danish, and Mitchell, Braxton D.

Published
2016
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